fibrodysplasia ossificans progressiva
Information
- Disease name
- fibrodysplasia ossificans progressiva
- Disease ID
- DOID:13374
- Description
- "A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene." [url:http\://en.wikipedia.org/wiki/Fibrodysplasia_ossificans_progressiva, url:http\://ghr.nlm.nih.gov/condition/fibrodysplasia-ossificans-progressiva, url:http\://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424023/, url:https\://www.ucsfbenioffchildrens.org/conditions/fibrodysplasia-ossificans-progressiva]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04818398 | Completed | Phase 1 | Study of Single-Ascending Doses of DS-6016a in Healthy Japanese Subjects | April 1, 2021 | July 26, 2022 |
| NCT02190747 | Completed | Phase 2 | An Efficacy and Safety Study of Palovarotene to Treat Preosseous Flare-ups in FOP Subjects | July 14, 2014 | May 23, 2016 |
| NCT02279095 | Completed | Phase 2 | An Open-Label Extension Study of Palovarotene Treatment in Fibrodysplasia Ossificans Progressiva (FOP) | October 9, 2014 | September 20, 2022 |
| NCT02322255 | Completed | A Natural History Study of Fibrodysplasia Ossificans Progressiva (FOP) | December 18, 2014 | April 9, 2020 | |
| NCT02066324 | Completed | Urine Sample Collection From FOP Patients | November 2013 | August 2014 | |
| NCT03188666 | Completed | Phase 2 | A Study to Examine the Safety, Tolerability and Effects on Abnormal Bone Formation of REGN2477 in Patients With Fibrodysplasia Ossificans Progressiva | February 26, 2018 | September 16, 2021 |
| NCT03312634 | Completed | Phase 3 | An Efficacy and Safety Study of Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva. | November 30, 2017 | September 7, 2022 |
| NCT04829773 | Completed | Phase 1 | Study Evaluating the Effect of Food on the Pharmacokinetics of Palovarotene and the Effect of Palovarotene on the Pharmacokinetics of the CYP3A4 Substrate Midazolam in Two Cohorts of Healthy Adult Subjects | January 3, 2019 | March 29, 2019 |
| NCT04665323 | Completed | An International Cross-sectional Survey to Evaluate the Burden of Fibrodysplasia Ossificans Progressiva (FOP) on Patients and Their Families. | January 18, 2021 | April 30, 2021 | |
| NCT06089616 | Not yet recruiting | A Study to Document and to Further Describe Long-term Safety and Effectiveness of Palovarotene in Participants With Fibrodysplasia Ossificans Progressiva (FOP) | April 15, 2024 | January 31, 2034 | |
| NCT04307953 | Recruiting | Phase 2 | Saracatinib Trial TO Prevent FOP | August 5, 2020 | May 6, 2025 |
| NCT05039515 | Recruiting | Phase 2 | A Study to Assess the Effectiveness and Safety of 2 Dosage Regimens of Oral Fidrisertib (IPN60130) for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP). | December 1, 2021 | August 30, 2029 |
| NCT05394116 | Recruiting | Phase 3 | A Study to Assess Safety, Tolerability and Efficacy of Garetosmab Versus Placebo Administered Intravenously (IV) in Adult Participants With Fibrodysplasia Ossificans Progressiva (FOP) | November 21, 2022 | June 12, 2026 |
| NCT02521792 | Terminated | Phase 2 | In-Home Evaluation of Episodic Administration of Palovarotene in Fibrodysplasia Ossificans Progressiva (FOP) Subjects | December 7, 2015 | August 4, 2016 |
- Disase is a (Disease Ontology)
- DOID:65
- Cross Reference ID (Disease Ontology)
- GARD:6445
- Cross Reference ID (Disease Ontology)
- ICD10CM:M61.1
- Cross Reference ID (Disease Ontology)
- ICD9CM:728.11
- Cross Reference ID (Disease Ontology)
- MESH:D009221
- Cross Reference ID (Disease Ontology)
- MIM:135100
- Cross Reference ID (Disease Ontology)
- NCI:C3040
- Cross Reference ID (Disease Ontology)
- ORDO:337
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:82725007
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0016037
- Exact Synonym (Disease Ontology)
- myositis ossificans progressiva
- Exact Synonym (Disease Ontology)
- progressive myositis ossificans
- Exact Synonym (Disease Ontology)
- progressive ossifying myositis
- Exact Synonym (Disease Ontology)
- Stone Man Syndrome
- OrphaNumber from OrphaNet (Orphanet)
- 337