Annotation Detail
Information
- Associated Genes
- MAPK1
- Associated Variants
-
MAPK1 MUTATION
MAPK1 MUTATION - Associated Disease
- Brain Neoplasms
- Source Database
- DisGeNET
- Description
- The naturally secreted and O-GlcNAcylated MIF binds to EGFR, thereby inhibiting the binding of EGF to EGFR and EGF-induced EGFR activation, phosphorylation of ERK and c-Jun, cell invasion, proliferation and brain tumour formation.
- Pubmed
- 26280537
- Section of the abstract supporting the evidence
- ALL_TEXT_2/3
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 4
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs