chr3:138652698:> Detail (hg38)

Information

Genome

Assembly Position
hg19 chr3:138,371,540-138,553,770 
hg38 chr3:138,652,698-138,834,928

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.005 renal cell carcinoma Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-indu... BeFree 24743574 Detail
0.005 renal cell carcinoma We genotyped 70 genes involved in the pathogenesis of renal-cell carcinoma (incl... BeFree 24767687 Detail
0.005 renal cell carcinoma The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway has been ide... BeFree 25757764 Detail
0.005 renal cell carcinoma PI3Kβ inhibitor TGX221 selectively inhibits renal cell carcinoma cells with both... BeFree 25853938 Detail
0.005 renal cell carcinoma Taken together, our findings indicate that ghrelin can activate Snail function v... BeFree 25925728 Detail
0.004 squamous cell carcinoma Importantly, the level of miR-508 correlates with poor survival and activated PI... BeFree 25099196 Detail
0.004 squamous cell carcinoma Moreover, blocking the whole PI3K-AKT-mTOR pathway with the PI3K/mTOR dual inhib... BeFree 26216950 Detail
<0.001 Carcinoma, Transitional Cell NA BeFree Detail
<0.001 Cardiomyopathy, Dilated NA BeFree Detail
<0.001 cerebral infarction NA BeFree Detail
0.003 Malignant tumor of cervix Taken together, our data suggest that anti-VEGFa treatment in cervical cancer ma... BeFree 25135429 Detail
0.003 Malignant tumor of cervix CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical ... BeFree 25310288 Detail
0.003 Malignant tumor of cervix Peroxisome proliferator-activated receptor-gamma agonist 4-O-methylhonokiol indu... BeFree 25563418 Detail
0.003 Malignant tumor of cervix The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein is pr... BeFree 25738254 Detail
0.003 Malignant tumor of cervix Butein suppresses cervical cancer growth through the PI3K/AKT/mTOR pathway. BeFree 25962638 Detail
<0.001 Chikungunya Fever In cells infected with the closely related chikungunya virus (CHIKV), the PI3K-A... BeFree 26339054 Detail
0.001 chondrosarcoma Stimulation of chondrosarcoma with CCL5 augmented PI3K and Akt phosphorylation, ... BeFree 25301739 Detail
<0.001 chordoma NA BeFree Detail
<0.001 choriocarcinoma NA BeFree Detail
<0.001 Congenital chromosomal disease In acute myeloid leukemia (AML), several signaling pathways such as the phosphat... BeFree 25322685 Detail
<0.001 colitis NA BeFree Detail
<0.001 Colonic Neoplasms NA BeFree Detail
0.012 colorectal carcinoma The added predictive value of additional biomarkers in the RAS-RAF-MAPK and PI3K... BeFree 24666267 Detail
0.012 colorectal carcinoma The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer. BeFree 25023051 Detail
0.012 colorectal carcinoma These data indicate that the capacity of retinol to inhibit PI3K activity confer... BeFree 25356626 Detail
0.012 colorectal carcinoma We conclude that cPLA2α is required for sustaining AKT phosphorylation at Ser473... BeFree 25365190 Detail
0.012 colorectal carcinoma Inhibitors against KRAS signaling mediators, namely, PI3K (phosphatidylinositol ... BeFree 25389372 Detail
0.012 colorectal carcinoma PTEN inactivation by mutation or allelic loss also occurs in CRCs. miR‑135b was ... BeFree 25571954 Detail
0.012 colorectal carcinoma The role of the PI3K pathway in colorectal cancer. BeFree 25591826 Detail
0.012 colorectal carcinoma Mutations in the RAS and PI3K pathways are associated with metastatic location i... BeFree 25920435 Detail
0.012 colorectal carcinoma Eight of these genes were linked to the Wnt, Hippo, TGF-β, EGF receptor, or PI3K... BeFree 26056301 Detail
<0.001 Colorectal Neoplasms NA BeFree Detail
<0.001 Coronary Arteriosclerosis bFGF regulates autophagy and ubiquitinated protein accumulation induced by myoca... BeFree 25787015 Detail
<0.001 cystadenoma NA BeFree Detail
<0.001 Phyllodes Tumor NA BeFree Detail
<0.001 scleroderma NA BeFree Detail
0.001 Diabetes NA BeFree Detail
0.002 diabetes mellitus NA BeFree Detail
0.010 Diabetes Mellitus, Non-Insulin-Dependent Effects of D-Pinitol on Insulin Resistance through the PI3K/Akt Signaling Pathwa... BeFree,GAD 26063468 Detail
<0.001 Diabetic Nephropathy Podocyte-specific genetic ablation of XBP1 or inducible expression of ATF6 in mi... BeFree 25754093 Detail
0.001 endometriosis NA BeFree Detail
<0.001 Ependymoma NA BeFree Detail
0.001 Esophageal Neoplasms Therefore, concomitant blockage of the ErbB2-PI3K pathway and the Hedgehog downs... BeFree 25435423 Detail
<0.001 fetal alcohol syndrome NA BeFree Detail
<0.001 fibrosarcoma NA BeFree Detail
<0.001 fragile X syndrome NA BeFree Detail
0.015 glioblastoma Moreover, TRIM24 regulates the expression of DNA repair enzyme O(6)-methylguanin... BeFree 24469053 Detail
0.015 glioblastoma ABT-263 (Navitoclax), an orally available small-molecule Bcl-2 inhibitor, and GD... BeFree 24757258 Detail
0.015 glioblastoma In this study, we used inhibitors to block specific signaling pathways, includin... BeFree 25048528 Detail
0.015 glioblastoma Application of a specific extracellular-related kinase 1/2 (ERK1/2) inhibitor, b... BeFree 25213694 Detail
0.015 glioblastoma However, due to the development of resistance mechanisms, kinase inhibition stud... BeFree 25256166 Detail
0.015 glioblastoma The EGFR and PI3K/mTORC1/2 pathways are frequently altered in glioblastoma (GBM)... BeFree 25316808 Detail
0.015 glioblastoma The activation of PI3K/Akt1 signaling pathway is involved in the proliferation o... BeFree 25501279 Detail
0.015 glioblastoma Further analyses revealed that Cyr61 seemed to activate PI3K/Akt/mTor signaling ... BeFree 25501701 Detail
0.010 Glioma TRIM24 promotes glioma progression and enhances chemoresistance through activati... BeFree 24469053 Detail
0.010 Glioma These results suggest that Liq treatment enhances glioma cell susceptibility to ... BeFree 25351348 Detail
0.010 Glioma Several studies have attempted to investigate the effects of combining the inhib... BeFree 25688137 Detail
0.010 Glioma The loss of MAGI3 expression in glioma may enhance the proliferation of glioma c... BeFree 26248734 Detail
<0.001 IgA glomerulonephritis NA BeFree Detail
<0.001 granulosa cell tumor NA BeFree Detail
<0.001 Graves Disease NA BeFree Detail
<0.001 Hamartoma NA BeFree Detail
<0.001 Hamartoma Syndrome, Multiple NA BeFree Detail
<0.001 Heart Diseases NA BeFree Detail
0.001 Heart failure NA BeFree Detail
0.001 congestive heart failure NA BeFree Detail
<0.001 Atrial Septal Defects NA BeFree Detail
<0.001 Hemangiosarcoma NA BeFree Detail
0.003 hepatitis C NA BeFree,GAD Detail
<0.001 Herpes Simplex Infections NA BeFree Detail
<0.001 Von Hippel-Lindau syndrome NA BeFree Detail
<0.001 Histiocytosis, Langerhans-Cell NA BeFree Detail
0.004 HIV Infections NA BeFree,GAD Detail
<0.001 Hodgkin Disease NA BeFree Detail
<0.001 hyperglycemia NA BeFree Detail
<0.001 hypoglycemia NA BeFree Detail
<0.001 Immunologic Deficiency Syndromes NA BeFree Detail
<0.001 Immune System Diseases This article highlights recent progress in characterizing the molecular mechanis... BeFree 25573003 Detail
0.001 influenza This novel mechanism of Dlg1 subversion by adenovirus to dysregulate PI3K could ... BeFree 24788832 Detail
0.002 Insulin resistance NA GAD Detail
<0.001 Intestinal Neoplasms NA BeFree Detail
<0.001 intestinal pseudo-obstruction NA BeFree Detail
0.002 ischemia In this study, we examined the effect of Ginsenoside Rb1 (GRb1) on ischemia/repe... BeFree 25257523 Detail
<0.001 Keloid NA BeFree Detail
<0.001 Kidney Failure, Acute NA BeFree Detail
<0.001 Kidney Neoplasm NA BeFree Detail
<0.001 leiomyosarcoma NA BeFree Detail
0.005 leukemia In the present study, we have shown for the first time that HBA decreased the ex... BeFree 25299784 Detail
0.005 leukemia The PI3K/Akt signaling pathway is constitutively activated in various leukemias. BeFree 26194899 Detail
0.003 chronic lymphocytic leukemia Altogether, these results underline the key role of PI3K/AKT pathway in the gene... BeFree 24825182 Detail
0.003 chronic lymphocytic leukemia The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelis... BeFree 25917267 Detail
<0.001 Acute Erythroblastic Leukemia NA BeFree Detail
<0.001 hairy cell leukemia NA BeFree Detail
0.002 Acute lymphocytic leukemia NA BeFree Detail
<0.001 Leukemia, Mast-Cell NA BeFree Detail
0.008 Leukemia, Myelocytic, Acute Importantly, emodin was demonstrated as a new inhibitor of PI3K/Akt in AML cells... BeFree 25174432 Detail
0.008 Leukemia, Myelocytic, Acute Inhibiting rescue pathways could improve the therapeutic efficacy of PI3K-target... BeFree 25322685 Detail
0.008 Leukemia, Myelocytic, Acute In the primary AML sample, we investigated the cell responses to ex vivo stimula... BeFree 25598437 Detail
0.008 Leukemia, Myelocytic, Acute The Ras/Raf/MAPK and PI3K/Akt/mTOR pathways are key signaling cascades involved ... BeFree 26044548 Detail
0.001 myeloid leukemia NA BeFree Detail
0.002 Myeloid Leukemia, Chronic The fusion gene bcr-abl develops chronic myeloid leukemia (CML), and stimulates ... BeFree 25644089 Detail
<0.001 Leukemia, Myeloid, Chronic-Phase NA BeFree Detail
<0.001 Leukemia, T-Cell NA BeFree Detail
<0.001 Adult T-Cell Lymphoma/Leukemia NA BeFree Detail
<0.001 lipodystrophy NA BeFree Detail
<0.001 lipomatosis NA BeFree Detail
<0.001 liposarcoma NA BeFree Detail
<0.001 liver cirrhosis NA BeFree Detail
<0.001 Liver diseases NA BeFree Detail
0.002 Liver neoplasms HBx induced AFP receptor expressed to activate PI3K/AKT signal to promote expres... BeFree 25943101 Detail
<0.001 Lung Neoplasms NA BeFree Detail
<0.001 Lupus Erythematosus, Systemic NA BeFree Detail
0.003 lymphoma NA BeFree Detail
<0.001 Lymphoma, Follicular NA BeFree Detail
<0.001 Lymphoproliferative Disorders NA BeFree Detail
<0.001 Waldenstrom Macroglobulinemia NA BeFree Detail
0.010 Malignant neoplasm of stomach In conclusion, knockdown of the c‑Met gene promoted gastric cancer cell apoptosi... BeFree 25395073 Detail
0.010 Malignant neoplasm of stomach Mechanically, PTP1B promotes gastric cancer cell proliferation, survival and inv... BeFree 25590580 Detail
0.010 Malignant neoplasm of stomach Therefore, our studies reveal for the first time that inhibition of the PI3K-Akt... BeFree 25640278 Detail
0.010 Malignant neoplasm of stomach Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Ak... BeFree 25727320 Detail
<0.001 mastocytosis NA BeFree Detail
0.002 medulloblastoma Targeting the PI3K/AKT/mTOR signaling pathway in medulloblastoma. BeFree 25601471 Detail
0.002 medulloblastoma The impact of RNA interference (RNAi)-mediated silencing of PI3K isoforms p110α ... BeFree 25915540 Detail
<0.001 multiple endocrine neoplasia type 2B NA BeFree Detail
<0.001 meningioma NA BeFree Detail
0.001 Mesothelioma NA BeFree Detail
<0.001 Metabolic Diseases Recent attention has focused on the role of phosphatidylinositol 3-kinase (PI3K)... BeFree 25512233 Detail
0.004 multiple myeloma Cancers like multiple myeloma (MM), which display elevated activity in key trans... BeFree 25197055 Detail
0.004 multiple myeloma Furthermore, our results demonstrated that the enforced expression of miR-145 in... BeFree 25369735 Detail
0.004 multiple myeloma Previously we showed that tetraspanin overexpression in MM cell lines attenuated... BeFree 25422161 Detail
<0.001 Mycobacterium Infections NA BeFree Detail
<0.001 mycosis fungoides In situ assessment of PI3K and PTEN alterations in mycosis fungoides: correlatio... BeFree 25267489 Detail
<0.001 myelofibrosis NA BeFree Detail
<0.001 Myeloproliferative disease Herein, we will review the clinically relevant inhibitors of the PI3K pathway th... BeFree 26062813 Detail
<0.001 myocardial infarction NA BeFree Detail
0.015 Neoplasm Metastasis Mechanistically, knockdown of FAP inactivated PTEN/PI3K/AKT and Ras-ERK and its ... BeFree 24722280 Detail
0.015 Neoplasm Metastasis IL-7 splicing variant IL-7δ5 induces EMT and metastasis of human breast cancer c... BeFree 24770666 Detail
0.015 Neoplasm Metastasis Molecular profiling of patient-matched brain and extracranial melanoma metastase... BeFree 24803579 Detail
0.015 Neoplasm Metastasis However, the mechanisms and specific functions of PI3K isoforms in tumor invasio... BeFree 24837077 Detail
0.015 Neoplasm Metastasis NOX4 promotes non-small cell lung cancer cell proliferation and metastasis throu... BeFree 24946933 Detail
0.015 Neoplasm Metastasis Yet, little is known concerning the role of the PI3K/Akt/Snail-dependent pathway... BeFree 25070581 Detail
0.015 Neoplasm Metastasis First-in-human study of CH5132799, an oral class I PI3K inhibitor, studying toxi... BeFree 25231405 Detail
0.015 Neoplasm Metastasis Overexpression of ribonuclease inhibitor defines good prognosis and suppresses p... BeFree 25257839 Detail
0.015 Neoplasm Metastasis These data indicate that the capacity of retinol to inhibit PI3K activity confer... BeFree 25356626 Detail
0.015 Neoplasm Metastasis These findings suggest that CEACAM6 enhances invasion and metastasis in GC by pr... BeFree 25398131 Detail
0.015 Neoplasm Metastasis These findings indicated that MALAT1 might suppress the tumor growth and metasta... BeFree 25431257 Detail
0.015 Neoplasm Metastasis In conclusion, this study suggested that EMT process can be triggered by the BMP... BeFree 25448881 Detail
0.015 Neoplasm Metastasis The EGFR/PI3K/PTEN/Akt/mTORC pathway plays prominent roles in malignant transfor... BeFree 25453219 Detail
0.015 Neoplasm Metastasis SPOCK1 as a potential cancer prognostic marker promotes the proliferation and me... BeFree 25623055 Detail
0.015 Neoplasm Metastasis The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR... BeFree 25677064 Detail
0.015 Neoplasm Metastasis Together, these results demonstrate that HGF/c-met can activate PI3K/Akt and dow... BeFree 25727320 Detail
0.015 Neoplasm Metastasis Mechanistic studies further revealed that VAV3 overexpression could dysregulate ... BeFree 25791293 Detail
<0.001 Embryonal Neoplasm NA BeFree Detail
<0.001 Neoplastic Syndromes, Hereditary NA BeFree Detail
<0.001 nephroblastoma NA BeFree Detail
<0.001 neurilemmoma We suggest that Nutlin-3, possibly in combination with FAK or PI3K inhibitors, c... BeFree 25217104 Detail
0.005 neuroblastoma Moreover, inhibitors of PI3K/mTOR and GLI signaling reduced neuroblastoma cell g... BeFree 25134527 Detail
0.005 neuroblastoma Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combinati... BeFree 25228590 Detail
0.005 neuroblastoma We previously demonstrated that PI3K Class IIβ (PI3KC2β) and its regulator inter... BeFree 25622909 Detail
<0.001 neurofibromatosis 1 NA BeFree Detail
0.005 obesity This integrated view of PI3K functions may ultimately help to develop new therap... BeFree,GAD 25512233 Detail
<0.001 Degenerative polyarthritis NA BeFree Detail
0.003 osteosarcoma Knockdown of CXCR7 suppressed proliferation and invasion of OS cells through dec... BeFree 24969680 Detail
0.003 osteosarcoma The present results indicated that LY294002 inhibits the malignant phenotype of ... BeFree 25351625 Detail
0.003 osteosarcoma Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vul... BeFree 25512523 Detail
0.003 osteosarcoma In conclusion, icariin possesses a reversal effect on multidrug resistance in MG... BeFree 25747987 Detail
0.016 ovarian carcinoma Re-expression of ARHI in ovarian cancer cells blocks signaling through the PI3K ... BeFree 24769729 Detail
0.016 ovarian carcinoma MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth fa... BeFree 25176450 Detail
0.016 ovarian carcinoma Inhibiting the PI3K/AKT pathway may be a useful treatment for ovarian carcinoma. BeFree 25216292 Detail
0.016 ovarian carcinoma Moreover, LY294002, a potent and specific cell-permeable inhibitor of phosphatid... BeFree 25340291 Detail
0.016 ovarian carcinoma The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer. BeFree 25677064 Detail
0.001 Pancreatic Neoplasm NA BeFree Detail
<0.001 papilloma NA BeFree Detail
<0.001 paraganglioma NA BeFree Detail
<0.001 pheochromocytoma NA BeFree Detail
<0.001 pituitary adenoma NA BeFree Detail
<0.001 Pituitary Neoplasms NA BeFree Detail
<0.001 polycystic ovary syndrome In type 2 diabetes, obesity and PCOS, there is, although with some variation fro... BeFree 25123125 Detail
<0.001 polycythemia vera NA BeFree Detail
<0.001 Adenomatous Polyposis Coli PTEN inactivation by mutation or allelic loss also occurs in CRCs. miR‑135b was ... BeFree 25571954 Detail
<0.001 Precancerous Conditions NA BeFree Detail
<0.001 Preleukemia NA BeFree Detail
0.004 Prostatic Neoplasms NA BeFree,LHGDN Detail
<0.001 pulmonary fibrosis NA BeFree Detail
0.001 retinoblastoma Genome-wide analyses have identified four major signaling nodes that are most fr... BeFree 25070358 Detail
0.001 retinoblastoma PIK3R3, an isoform of class IA phosphoinositide 3-kinase (PI3K), specifically in... BeFree 25371235 Detail
0.002 rhabdomyosarcoma In the present study, we searched for combination therapies with the dual PI3K/m... BeFree 25637161 Detail
0.002 rhabdomyosarcoma Thus, combined GLI1/2 and PI3K/mTOR inhibition represents a promising novel appr... BeFree 25749378 Detail
0.010 Diabetes Mellitus, Non-Insulin-Dependent The aim of our study was to investigate whether common polymorphisms in the gene... BeFree 15127203 Detail
0.123 schizophrenia NA BeFree,CTD_human,GAD Detail
<0.001 systemic scleroderma NA BeFree Detail
<0.001 Seizures These data are the first to demonstrate that the inflammatory response induced b... BeFree 25903737 Detail
<0.001 Septicemia NA BeFree Detail
<0.001 Dermatologic disorders NA BeFree Detail
<0.001 Skin lesion We have already shown that AKT is activated in skin lesions in Mycosis Fungoides... BeFree 25267489 Detail
<0.001 Stomach Neoplasms NA BeFree Detail
<0.001 Cerebrovascular accident In conclusion, IL-8 stimulates VEGF production in hBM-MSCs in part via the PI3K/... BeFree 24797366 Detail
<0.001 synovial sarcoma NA BeFree Detail
0.080 thrombosis NA RGD Detail
0.002 thymoma NA BeFree Detail
0.002 Thyroid Neoplasm NA BeFree Detail
<0.001 Chagas disease NA BeFree Detail
<0.001 tuberculosis NA BeFree Detail
0.003 tuberous sclerosis In addition, the phosphoinositide-3-kinase (PI3K)/Akt/mammalian target of rapamy... BeFree 25153728 Detail
<0.001 Attention Deficit Disorder NA BeFree Detail
<0.001 urticaria pigmentosa NA BeFree Detail
0.001 Virus Diseases The phosphatidylinositol-3-kinase (PI3K) and Akt pathway is activated in host im... BeFree 25158146 Detail
0.001 B-Cell Lymphomas Many alterations directly or indirectly lead to activation of survival signaling... BeFree 24811162 Detail
0.001 B-Cell Lymphomas The oncogenic PI3K/serine-threonine kinase (PI3K/AKT) pathway is a downstream pa... BeFree 25862915 Detail
0.123 diffuse large B-cell lymphoma Inhibition of the PI3K/Akt/mTOR signaling pathway in diffuse large B-cell lympho... BeFree,CTD_human 25215588 Detail
<0.001 Lymphoma, T-Cell, Cutaneous NA BeFree Detail
<0.001 peripheral T-cell lymphoma We suggest that targeting the PI3K/AKT pathway may be a promising therapeutic st... BeFree 25862915 Detail
<0.001 Liver failure NA BeFree Detail
0.001 acute leukemia NA BeFree Detail
<0.001 Rous Sarcoma NA BeFree Detail
0.001 Small cell carcinoma of lung This study reveals a critical role for the PTEN/PI3K pathway in both SCLC and lu... BeFree 24482365 Detail
0.001 Small cell carcinoma of lung The PI3K/AKT/mTOR pathway is distinguishable in SCLC genomic alterations. BeFree 25122428 Detail
<0.001 Oral Cavity Carcinoma NA BeFree Detail
<0.001 Myocardial Ischemia bFGF regulates autophagy and ubiquitinated protein accumulation induced by myoca... BeFree 25787015 Detail
0.002 Adenocarcinoma of lung (disorder) These data identify RIT1 as a driver oncogene in a specific subset of lung adeno... BeFree 24469055 Detail
0.002 Adenocarcinoma of lung (disorder) This study reveals a critical role for the PTEN/PI3K pathway in both SCLC and lu... BeFree 24482365 Detail
0.002 Adenocarcinoma of lung (disorder) ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcin... BeFree 25596284 Detail
0.002 Adenocarcinoma of lung (disorder) Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of R... BeFree 26023239 Detail
0.001 esophageal carcinoma Therefore, concomitant blockage of the ErbB2-PI3K pathway and the Hedgehog downs... BeFree 25435423 Detail
0.001 esophageal carcinoma Immunohistochemical and molecular analysis of PI3K/AKT/mTOR pathway in esophagea... BeFree 25912437 Detail
<0.001 Malignant neoplasm of mouth NA BeFree Detail
<0.001 Malignant neoplasm of nasopharynx NA BeFree Detail
<0.001 Malignant neoplasm of gallbladder We found that activation of the PI3K/Akt pathway was involved in the oncogenic f... BeFree 25623055 Detail
<0.001 uterine cancer NA BeFree Detail
<0.001 Malignant neoplasm of brain NA BeFree Detail
<0.001 Secondary malignant neoplasm of lung NA BeFree Detail
<0.001 Obstructive chronic bronchitis with acute exacerbation NA BeFree Detail
<0.001 porphyria cutanea tarda NA BeFree Detail
<0.001 Saethre-Chotzen syndrome NA BeFree Detail
<0.001 LEOPARD Syndrome NA BeFree Detail
0.004 Tumor Progression We propose the simultaneous activation of PLC-PKC-MEK1/2-ERK1/2 and PI3K pathway... BeFree 24909096 Detail
0.004 Tumor Progression These findings uncover a mechanism for constitutive PI3K/Akt activation in ESCC,... BeFree 25099196 Detail
0.004 Tumor Progression Our data showed that the PTEN/PI3K pathway was active in human ESCC tissues in v... BeFree 25175594 Detail
0.004 Tumor Progression The PI3K/AKT signal transduction pathway has distinct functional roles in tumor ... BeFree 25771729 Detail
<0.001 Anaplastic carcinoma NA BeFree Detail
<0.001 Ki-1+ Anaplastic Large Cell Lymphoma In addition to the commonly known AP-1 activators Mitogen-Activated Protein Kina... BeFree 25961698 Detail
<0.001 hepatoblastoma Anticancer effect of calycopterin via PI3K/Akt and MAPK signaling pathways, ROS-... BeFree 25060910 Detail
<0.001 Liposarcoma, Myxoid NA BeFree Detail
<0.001 Rhabdomyosarcoma, Embryonal NA BeFree Detail
<0.001 Adenocarcinoma, Clear Cell Crosstalk between PI3K and Ras pathways via protein phosphatase 2A in human ovar... BeFree 25756515 Detail
0.002 Follicular thyroid carcinoma NA BeFree Detail
<0.001 Carcinoma, Endometrioid Preclinical investigations have suggested that the PI3K/AKT/mTOR pathway is freq... BeFree 25677064 Detail
<0.001 Carcinoma, Endometrioid The efficacy of both PI3K and MEK inhibitors was evaluated in a model of endomet... BeFree 26232337 Detail
<0.001 cholangiocarcinoma NA BeFree Detail
<0.001 Cystadenocarcinoma, Serous NA BeFree Detail
<0.001 Klatskin tumor NA BeFree Detail
<0.001 Rhabdoid Tumor NA BeFree Detail
0.001 Neuroendocrine Tumors Neuroendocrine cancer cell lines are used to investigate therapeutic targets in ... BeFree 26087898 Detail
<0.001 uveal melanoma NA BeFree Detail
0.001 Lip and oral cavity carcinoma NA BeFree Detail
<0.001 Macrocephaly NA BeFree Detail
<0.001 gallbladder carcinoma We found that activation of the PI3K/Akt pathway was involved in the oncogenic f... BeFree 25623055 Detail
0.007 pancreatic carcinoma Further analysis showed that Cyr61 seemed to activate phosphatidylinositol 3-kin... BeFree 25104090 Detail
0.007 pancreatic carcinoma Recent data identify 3-phosphoinositide-dependent protein kinase 1 as a key tumo... BeFree 25152578 Detail
0.007 pancreatic carcinoma Activation of phosphoinositide-3 kinase (PI3K)-AKT-mammalian target of rapamycin... BeFree 25285629 Detail
0.007 pancreatic carcinoma Taken together, these data indicate that inhibition of MEK and PI3K alone or in ... BeFree 25376606 Detail
0.002 Gastrointestinal Stromal Tumors microRNA-218 increase the sensitivity of gastrointestinal stromal tumor to imati... BeFree 24706111 Detail
0.002 Gastrointestinal Stromal Tumors We tested the in vivo efficacy of three PI3K inhibitors (PI3Ki) in patient-deriv... BeFree 25316817 Detail
<0.001 Cancer of Nasopharynx NA BeFree Detail
0.002 Anaplastic thyroid carcinoma Here, we outlined the common pathways that are altered in ATC, including the BRA... BeFree 25347569 Detail
<0.001 Medullary carcinoma of thyroid PI3K/Akt/mTOR: A promising therapeutic target for non-medullary thyroid carcinom... BeFree 26138515 Detail
0.002 Papillary thyroid carcinoma NA BeFree Detail
0.009 Malignant neoplasm of lung RNA interference-mediated knockdown of RhoGDI2 induces the migration and invasio... BeFree 25266803 Detail
0.009 Malignant neoplasm of lung Common molecular drivers of lung cancer are mutations in receptor tyrosine kinas... BeFree 25524703 Detail
0.009 Malignant neoplasm of lung When the chimeric ubiquitin ligases were introduced into lung cancer SPC-A1 cell... BeFree 25573345 Detail
0.009 Malignant neoplasm of lung The altered PI3K/mTOR pathway is implicated in lung cancer, but mTOR inhibitors ... BeFree 25673697 Detail
0.009 Malignant neoplasm of lung It was found that AKT1 and PI3K/p85 expression was upregulated in LCSCs compared... BeFree 25738369 Detail
0.009 Malignant neoplasm of lung Hepatocyte growth factor (HGF) induces resistance to reversible and irreversible... BeFree 26063323 Detail
<0.001 age related macular degeneration NA BeFree Detail
<0.001 Systemic Inflammatory Response Syndrome NA BeFree Detail
<0.001 Sepsis NA BeFree Detail
<0.001 Carcinoma, Small Cell NA BeFree Detail
<0.001 Bannayan-Riley-Ruvalcaba syndrome NA BeFree Detail
<0.001 polymicrogyria NA BeFree Detail
0.003 Impaired glucose tolerance NA BeFree,GAD Detail
<0.001 Virchow's node (disorder) Genome-wide analyses have identified four major signaling nodes that are most fr... BeFree 25070358 Detail
<0.001 Familial Alzheimer Disease (FAD) NA BeFree Detail
<0.001 Stage II Colon Cancer NA BeFree Detail
0.002 Carcinoma breast stage IV Here, resistance to a class I PI3K inhibitor in a model of metastatic breast can... BeFree 26058079 Detail
<0.001 inflammatory breast carcinoma Molecular aberrations affecting the PI3K pathway may play a role in the progress... BeFree 24634376 Detail
<0.001 Stage IV Bladder Cancer AJCC v6 NA BeFree Detail
<0.001 Prostate cancer recurrent Activation of the PI3K/AKT signal pathway is a known driving force for the progr... BeFree 24983969 Detail
<0.001 Metastatic melanoma Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prog... BeFree 25168062 Detail
<0.001 Cancer of Head and Neck NA BeFree Detail
<0.001 Liver and Intrahepatic Biliary Tract Carcinoma NA BeFree Detail
<0.001 B-cell adult acute lymphoblastic leukemia Our studies indicate that CK2-mediated PTEN posttranslational inactivation, asso... BeFree 24561792 Detail
0.001 Squamous cell carcinoma of esophagus Disruption of the PTEN/PI3K pathway involved in TGF-β1-induced EMT may provide p... BeFree 25175594 Detail
0.001 Squamous cell carcinoma of esophagus Notably, high activity of hedgehog signaling and the PI3K pathway in approximate... BeFree 25839328 Detail
0.001 Squamous cell carcinoma of esophagus Dasatinib enhances cisplatin sensitivity in human esophageal squamous cell carci... BeFree 25843419 Detail
<0.001 Adenocarcinoma Of Esophagus ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal ... BeFree 25435423 Detail
<0.001 cervical squamous cell carcinoma The objective of this study was to investigate the predictive value of common ge... BeFree 25773678 Detail
0.001 Conventional (Clear Cell) Renal Cell Carcinoma Loss of MLH1 confers resistance to PI3Kβ inhibitors in renal clear cell carcinom... BeFree 25528216 Detail
0.001 Conventional (Clear Cell) Renal Cell Carcinoma We identified the selective PI3Kβ inhibitor TGX221 as a selective inhibitor for ... BeFree 25853938 Detail
0.001 Conventional (Clear Cell) Renal Cell Carcinoma High selectivity of PI3Kβ inhibitors in SETD2-mutated renal clear cell carcinoma... BeFree 26537074 Detail
0.003 Solid tumour First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phos... BeFree 25370471 Detail
0.003 Solid tumour BYL719, which selectively inhibits the alpha isoform of the phosphatidylinositol... BeFree 25544637 Detail
<0.001 Adenocarcinoma of pancreas NA BeFree Detail
<0.001 Prostatic Intraepithelial Neoplasias NA BeFree Detail
0.003 cervix carcinoma Taken together, our data suggest that anti-VEGFa treatment in cervical cancer ma... BeFree 25135429 Detail
0.003 cervix carcinoma CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical ... BeFree 25310288 Detail
0.003 cervix carcinoma Peroxisome proliferator-activated receptor-gamma agonist 4-O-methylhonokiol indu... BeFree 25563418 Detail
0.003 cervix carcinoma The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein is pr... BeFree 25738254 Detail
0.003 cervix carcinoma Butein suppresses cervical cancer growth through the PI3K/AKT/mTOR pathway. BeFree 25962638 Detail
<0.001 Carcinoid tumor no ICD-O subtype NA BeFree Detail
<0.001 Ceruminous adenoma NA BeFree Detail
<0.001 Round cell liposarcoma NA BeFree Detail
<0.001 anaplastic astrocytoma NA BeFree Detail
<0.001 pilocytic astrocytoma NA BeFree Detail
0.003 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse NA BeFree Detail
<0.001 Adenocarcinoma of colon In this study, the inhibitory effect of KYNA on activation of phosphoinositide 3... BeFree 25012123 Detail
<0.001 Impaired cognition NA BeFree Detail
<0.001 Malignant neoplasm of liver NA BeFree Detail
<0.001 malignant mesothelioma NA BeFree Detail
0.007 Malignant neoplasm of pancreas Recent data identify 3-phosphoinositide-dependent protein kinase 1 as a key tumo... BeFree 25152578 Detail
0.007 Malignant neoplasm of pancreas Activation of phosphoinositide-3 kinase (PI3K)-AKT-mammalian target of rapamycin... BeFree 25285629 Detail
0.007 Malignant neoplasm of pancreas Taken together, these data indicate that inhibition of MEK and PI3K alone or in ... BeFree 25376606 Detail
<0.001 Disseminated Malignant Neoplasm First-in-human study of CH5132799, an oral class I PI3K inhibitor, studying toxi... BeFree 25231405 Detail
<0.001 juvenile myelomonocytic leukemia Juvenile myelomonocytic leukaemia-associated mutation in Cbl promotes resistance... BeFree 24469048 Detail
0.017 Malignant neoplasm of prostate We identified differential therapeutic vulnerabilities that emerge upon the loss... BeFree 24866151 Detail
0.017 Malignant neoplasm of prostate A genome-wide RNAi screen identifies FOXO4 as a metastasis-suppressor through co... BeFree 24983969 Detail
0.017 Malignant neoplasm of prostate The impact of miRNA on the canonical TGF-β Smad signalling pathway has been well... BeFree 24985060 Detail
0.017 Malignant neoplasm of prostate Restoration of PTEN expression or inhibition of PI3K action decreased cPLA₂α exp... BeFree 25026288 Detail
0.017 Malignant neoplasm of prostate Genome-wide analyses have identified four major signaling nodes that are most fr... BeFree 25070358 Detail
0.017 Malignant neoplasm of prostate Targeting the PI3K/Akt pathway in prostate cancer: challenges and opportunities ... BeFree 25120209 Detail
0.017 Malignant neoplasm of prostate The findings from this study suggest that the combination of dual PI3K/Akt/mTOR ... BeFree 25275598 Detail
0.017 Malignant neoplasm of prostate Co-targeting AR and PI3K/AKT signaling has been proposed to be a more effective ... BeFree 25360799 Detail
0.017 Malignant neoplasm of prostate The Upregulation of PI3K/Akt and MAP Kinase Pathways is Associated with Resistan... BeFree 25640606 Detail
0.017 Malignant neoplasm of prostate Among the cancer networks and STNs we considered, it is found that there is a su... BeFree 25707690 Detail
0.001 Hematologic Neoplasms NA BeFree Detail
<0.001 Chorea Acanthocytosis Syndrome NA BeFree Detail
<0.001 Lymphatic Abnormalities The activation of a central growth/survival pathway (PI3K/AKT) represents a feas... BeFree 25292196 Detail
<0.001 Hemimegalencephaly NA BeFree Detail
<0.001 Endometrioid tumor Endometrial cancers have been recently molecularly characterized; amplifications... BeFree 24820961 Detail
0.012 endometrial carcinoma The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal tra... BeFree 25141911 Detail
0.012 endometrial carcinoma This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pa... BeFree 25301678 Detail
0.012 endometrial carcinoma The phosphoinositol-3 kinase (PI3K) pathway is frequently dysregulated in endome... BeFree 25624430 Detail
0.012 endometrial carcinoma PIKing the type and pattern of PI3K pathway mutations in endometrioid endometria... BeFree 25701704 Detail
0.012 endometrial carcinoma NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activat... BeFree 26193427 Detail
<0.001 Secondary malignant neoplasm of liver NA BeFree Detail
<0.001 dementia NA BeFree Detail
<0.001 Recurrent tumor Other molecular alterations, like mTOR or PI3K pathway deregulation, or Matrilin... BeFree 24554201 Detail
<0.001 Increased drug resistance NA BeFree Detail
<0.001 Metabolic syndrome X NA BeFree Detail
<0.001 Neurodegenerative Disorders NA BeFree Detail
<0.001 Mood Disorders NA BeFree Detail
<0.001 Myxoid/Round Cell Liposarcoma NA BeFree Detail
0.003 Malignant neoplasm of esophagus Therefore, concomitant blockage of the ErbB2-PI3K pathway and the Hedgehog downs... BeFree,GAD 25435423 Detail
0.007 Thyroid carcinoma The present review focuses on the most recent developments on the role of the PI... BeFree 26138515 Detail
0.001 Ewings sarcoma We further show that expression of PTEN, a well-established, potent tumor suppre... BeFree 25603314 Detail
<0.001 Squamous cell carcinoma of skin Y-box Binding Protein-1 Is Part of a Complex Molecular Network Linking ΔNp63α to... BeFree 25639555 Detail
<0.001 Malignant glioma NA BeFree Detail
<0.001 Tonsillar Carcinoma Divergence of P53, PTEN, PI3K, Akt and mTOR expression in tonsillar cancer. BeFree 24616007 Detail
<0.001 Infected ascites NA BeFree Detail
0.003 Osteosarcoma of bone Knockdown of CXCR7 suppressed proliferation and invasion of OS cells through dec... BeFree 24969680 Detail
0.003 Osteosarcoma of bone The present results indicated that LY294002 inhibits the malignant phenotype of ... BeFree 25351625 Detail
0.003 Osteosarcoma of bone Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vul... BeFree 25512523 Detail
0.003 Osteosarcoma of bone In conclusion, icariin possesses a reversal effect on multidrug resistance in MG... BeFree 25747987 Detail
<0.001 Costello syndrome (disorder) Costello syndrome (CS) is a rare genetic disorder caused, in the majority of cas... BeFree 25367099 Detail
<0.001 Carcinoma of larynx NA BeFree Detail
0.035 Carcinogenesis When combined with previous studies, our data suggest that dual induction of PAR... BeFree 24469043 Detail
0.035 Carcinogenesis The phosphatidylinositol 3-kinase (PI3K), MAP kinase (MAPK), and related pathway... BeFree 24700299 Detail
0.035 Carcinogenesis R-Ras2 drives tumorigenesis in a phosphatidylinostiol-3 kinase (PI3K)-dependent ... BeFree 24826867 Detail
0.035 Carcinogenesis We further show that superactivation of the prosurvival PI3K-AKT signaling pathw... BeFree 24866151 Detail
0.035 Carcinogenesis These findings further suggest that regulation of SUMOylation by PI3K/Akt signal... BeFree 24954506 Detail
0.035 Carcinogenesis The findings indicate that epigenetic inactivation of INPP4B is one of the key m... BeFree 25126743 Detail
0.035 Carcinogenesis Furthermore, miR-200a induces cell transformation and tumorigenesis in immunocom... BeFree 25239643 Detail
0.035 Carcinogenesis We here demonstrate that PIK3CA mutations, PTEN loss, PI3K and KRAS activation a... BeFree 25415225 Detail
0.035 Carcinogenesis Phosphatidylinositol 3-kinases (PI3Ks) play important roles in human tumorigenes... BeFree 25622909 Detail
0.035 Carcinogenesis Given the contribution of HRG signaling and the PI3K-Akt pathway in particular t... BeFree 25630670 Detail
0.035 Carcinogenesis The PI3K/Akt and MAP kinase pathways play important roles in a variety of normal... BeFree 25640606 Detail
0.035 Carcinogenesis Single nucleotide polymorphisms (SNPs) in the PI3K/PTEN/AKT/mTOR signaling pathw... BeFree 25654238 Detail
0.035 Carcinogenesis Pathways known to affect tumorigenesis across a wide spectrum of tissues are dys... BeFree 25726356 Detail
0.035 Carcinogenesis The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway appears to be a key r... BeFree 25738254 Detail
0.035 Carcinogenesis Our findings support the de-regulation of the PI3K/Akt/mTOR and MAPK signaling p... BeFree 25862896 Detail
0.002 Leukemogenesis NA BeFree Detail
<0.001 Tumor Initiation NA BeFree Detail
0.017 prostate carcinoma We identified differential therapeutic vulnerabilities that emerge upon the loss... BeFree 24866151 Detail
0.017 prostate carcinoma A genome-wide RNAi screen identifies FOXO4 as a metastasis-suppressor through co... BeFree 24983969 Detail
0.017 prostate carcinoma The impact of miRNA on the canonical TGF-β Smad signalling pathway has been well... BeFree 24985060 Detail
0.017 prostate carcinoma Restoration of PTEN expression or inhibition of PI3K action decreased cPLA₂α exp... BeFree 25026288 Detail
0.017 prostate carcinoma Genome-wide analyses have identified four major signaling nodes that are most fr... BeFree 25070358 Detail
0.017 prostate carcinoma Targeting the PI3K/Akt pathway in prostate cancer: challenges and opportunities ... BeFree 25120209 Detail
0.017 prostate carcinoma The findings from this study suggest that the combination of dual PI3K/Akt/mTOR ... BeFree 25275598 Detail
0.017 prostate carcinoma Co-targeting AR and PI3K/AKT signaling has been proposed to be a more effective ... BeFree 25360799 Detail
0.017 prostate carcinoma The Upregulation of PI3K/Akt and MAP Kinase Pathways is Associated with Resistan... BeFree 25640606 Detail
0.017 prostate carcinoma Among the cancer networks and STNs we considered, it is found that there is a su... BeFree 25707690 Detail
0.004 Epithelial ovarian cancer Inhibiting the PI3K/AKT pathway may be a useful treatment for ovarian carcinoma. BeFree 25216292 Detail
0.004 Epithelial ovarian cancer In conclusion, the results of the present study demonstrated that PI3K/AKT and R... BeFree 25405658 Detail
0.004 Epithelial ovarian cancer These findings revealed that miR‑338‑3p may act as a tumor suppressor that block... BeFree 25776272 Detail
<0.001 invasive cancer Therefore, the hyperactivity of PI3K/Akt pathway and elevated levels of p53R2 ca... BeFree 25086499 Detail
<0.001 Refractory cancer NA BeFree Detail
0.043 breast carcinoma Direct inhibition of PI3K in combination with dual HER2 inhibitors is required f... BeFree 24451154 Detail
0.043 breast carcinoma Characterization of breast cancers with PI3K mutations in an academic practice s... BeFree 24722917 Detail
0.043 breast carcinoma Their prognostic value and that of the phosphatidylinositol 3-kinase (PI3K) path... BeFree 24981670 Detail
0.043 breast carcinoma Phosphatidylinositol 3-kinase (PI3K) pathway deregulation (that is PIK3CA mutati... BeFree 25056500 Detail
0.043 breast carcinoma Western blot analysis data indicate that MAPK/ERK and PI3K/Akt signaling in brea... BeFree 25127034 Detail
0.043 breast carcinoma Microarray phosphatome profiling of breast cancer patients unveils a complex pho... BeFree 25201346 Detail
0.043 breast carcinoma In the present study, we have shown for the first time that HBA decreased the ex... BeFree 25299784 Detail
0.043 breast carcinoma Axl as a downstream effector of TGF-β1 via PI3K/Akt-PAK1 signaling pathway promo... BeFree 25327287 Detail
0.043 breast carcinoma Regulation of the cell cycle and PI3K/Akt/mTOR signaling pathway by tanshinone I... BeFree 25355053 Detail
0.043 breast carcinoma LYN(D189Y) overexpression abrogated growth inhibition by fulvestrant and/or the ... BeFree 25401474 Detail
0.043 breast carcinoma Phosphatidylinositol-3-kinase (PI3K)/AKT pathway mutations are associated with c... BeFree 25422220 Detail
0.043 breast carcinoma The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrin... BeFree 25491778 Detail
0.043 breast carcinoma In conclusion, activating the PI3K pathway is associated with low pCR to trastuz... BeFree 25542038 Detail
0.043 breast carcinoma Estrogen-responsive genes most significantly influenced by cohesin were enriched... BeFree 25542856 Detail
0.043 breast carcinoma BYL719, which selectively inhibits the alpha isoform of the phosphatidylinositol... BeFree 25544637 Detail
0.043 breast carcinoma We investigated whether mutations in the gene encoding the phosphatidylinositol ... BeFree 25559818 Detail
0.043 breast carcinoma In the present study, we demonstrate that PI3K pathway regulates phenotypic chan... BeFree 25643809 Detail
0.043 breast carcinoma Further, PI3K is thought to be the main driver of lapatinib resistance, but our ... BeFree 25692408 Detail
0.043 breast carcinoma The epidermal growth factor receptor (EGFR)/PI3K/AKT signaling pathway aberratio... BeFree 25702787 Detail
0.043 breast carcinoma In the present study, the protein expression levels of SET, protein phosphatase ... BeFree 25760096 Detail
0.043 breast carcinoma PI3K inhibition results in enhanced estrogen receptor function and dependence in... BeFree 25877889 Detail
0.043 breast carcinoma IL-8/PI3K/Akt/NF-κB/integrin β3 axis may be exploited for therapeutic interventi... BeFree 25979232 Detail
0.043 breast carcinoma Beyond ER and HER2, BRCA and PIK3CA mutations (when targeted with alpha-specific... BeFree 25993174 Detail
0.043 breast carcinoma Taken together, the prostacyclin/IP/PI3K-p38 MAPK axis has emerged as a novel pr... BeFree 26067757 Detail
0.043 breast carcinoma Resistance to trastuzumab in patients with HER2-overexpressing breast cancer is ... BeFree 26247526 Detail
0.043 breast carcinoma Collectively, our findings identify PIPP as a suppressor of oncogenic PI3K/AKT s... BeFree 26267533 Detail
0.043 breast carcinoma Inhibition of Autophagy Increases Proliferation Inhibition and Apoptosis Induced... BeFree 26427150 Detail
0.008 Carcinoma of lung RNA interference-mediated knockdown of RhoGDI2 induces the migration and invasio... BeFree 25266803 Detail
0.008 Carcinoma of lung Common molecular drivers of lung cancer are mutations in receptor tyrosine kinas... BeFree 25524703 Detail
0.008 Carcinoma of lung When the chimeric ubiquitin ligases were introduced into lung cancer SPC-A1 cell... BeFree 25573345 Detail
0.008 Carcinoma of lung The altered PI3K/mTOR pathway is implicated in lung cancer, but mTOR inhibitors ... BeFree 25673697 Detail
0.008 Carcinoma of lung It was found that AKT1 and PI3K/p85 expression was upregulated in LCSCs compared... BeFree 25738369 Detail
0.008 Carcinoma of lung Hepatocyte growth factor (HGF) induces resistance to reversible and irreversible... BeFree 26063323 Detail
<0.001 Secondary malignant neoplasm of lymph node Our data showed that the PTEN/PI3K pathway was active in human ESCC tissues in v... BeFree 25175594 Detail
0.007 colon carcinoma Synergism of PI3K/Akt inhibition and Fas activation on colon cancer cell death. BeFree 25199763 Detail
0.007 colon carcinoma Quinazoline based small molecule exerts potent tumour suppressive properties by ... BeFree 25554016 Detail
0.007 colon carcinoma In the present study, the expression status of miR-218 and the role of the phosp... BeFree 25760926 Detail
0.007 colon carcinoma Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway gene... BeFree 25889965 Detail
0.007 colon carcinoma Here, we detected its effects on DLD-1 and SW480 (two human colon cancer cell li... BeFree 26225471 Detail
0.011 stomach carcinoma These data suggest that EGF-induced activation of MMP7 and MMP13 in GC is throug... BeFree 25085584 Detail
0.011 stomach carcinoma In conclusion, knockdown of the c‑Met gene promoted gastric cancer cell apoptosi... BeFree 25395073 Detail
0.011 stomach carcinoma Mechanically, PTP1B promotes gastric cancer cell proliferation, survival and inv... BeFree 25590580 Detail
0.011 stomach carcinoma Therefore, our studies reveal for the first time that inhibition of the PI3K-Akt... BeFree 25640278 Detail
0.011 stomach carcinoma Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Ak... BeFree 25727320 Detail
0.003 Carcinoma of bladder These findings may have high relevance in terms of using PI3K-targeted therapies... BeFree 24347284 Detail
0.003 Carcinoma of bladder Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential us... BeFree 24929024 Detail
0.003 Carcinoma of bladder Our findings suggest that miR-21 acts as a molecular switch to regulate aerobic ... BeFree 25266796 Detail
0.003 Carcinoma of bladder Taken together, EN2 may be a candidate oncogene in BC by activating the PI3K/Akt... BeFree 25812440 Detail
<0.001 Malignant Female Reproductive System Neoplasm This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pa... BeFree 25301678 Detail
<0.001 skin carcinoma NA BeFree Detail
0.005 Central neuroblastoma Moreover, inhibitors of PI3K/mTOR and GLI signaling reduced neuroblastoma cell g... BeFree 25134527 Detail
0.005 Central neuroblastoma Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combinati... BeFree 25228590 Detail
0.005 Central neuroblastoma We previously demonstrated that PI3K Class IIβ (PI3KC2β) and its regulator inter... BeFree 25622909 Detail
<0.001 Malignant neoplasm of kidney NA BeFree Detail
<0.001 biliary tract cancer Targeted inhibition of the PI3K/mTOR and Hhpathways indicates a new avenue for B... BeFree 25742482 Detail
<0.001 Malignant neoplasm tonsil Divergence of P53, PTEN, PI3K, Akt and mTOR expression in tonsillar cancer. BeFree 24616007 Detail
<0.001 Malignant Squamous Cell Neoplasm NA BeFree Detail
0.001 malignant pleural mesothelioma MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant p... BeFree 25221930 Detail
<0.001 Metastatic Endometrial Carcinoma NA BeFree Detail
<0.001 Heartburn acidity NA BeFree Detail
<0.001 Helicobacter pylori infection Inhibition of PI3K and Akt kinase prevented the phosphorylation of 4E-BP1, sugge... BeFree 25194338 Detail
<0.001 Invasive breast carcinoma PI3K pathway activation in high-grade ductal carcinoma in situ--implications for... BeFree 24634376 Detail
0.002 Rhabdoid Tumor of the Kidney Our model allowed us to test the contributions of oncogenes in the RTK/RAS/PI(3)... BeFree 24752661 Detail
<0.001 Diffuse large B-cell lymphoma recurrent NA BeFree Detail
<0.001 Philadelphia chromosome positive NA BeFree Detail
<0.001 dedifferentiated chondrosarcoma NA BeFree Detail
<0.001 latent infection NA BeFree Detail
<0.001 Advanced cancer NA BeFree Detail
<0.001 Erdheim-Chester disease NA BeFree Detail
<0.001 SHORT syndrome NA BeFree Detail
<0.001 Cerebral Ischemia NA BeFree Detail
<0.001 ovarian neoplasm NA BeFree Detail
<0.001 Metastatic Prostate Carcinoma NA BeFree Detail
<0.001 Colorectal cancer metastatic NA BeFree Detail
<0.001 Drug Resistant Epilepsy In this study we performed multiplex targeted sequencing of 10 genes in the PI3K... BeFree 25722288 Detail
0.013 Malignant neoplasm of ovary Re-expression of ARHI in ovarian cancer cells blocks signaling through the PI3K ... BeFree 24769729 Detail
0.013 Malignant neoplasm of ovary MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth fa... BeFree 25176450 Detail
0.013 Malignant neoplasm of ovary Moreover, LY294002, a potent and specific cell-permeable inhibitor of phosphatid... BeFree 25340291 Detail
0.013 Malignant neoplasm of ovary The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer. BeFree 25677064 Detail
<0.001 High-Grade Prostatic Intraepithelial Neoplasia NA BeFree Detail
0.005 Squamous cell carcinoma of the head and neck A comprehensive evaluation of biomarkers predictive of response to PI3K inhibito... BeFree 25193510 Detail
0.005 Squamous cell carcinoma of the head and neck Additional study is required to develop new model systems and approaches to dete... BeFree 25855885 Detail
<0.001 Mammary Carcinoma, Human NA BeFree Detail
<0.001 Morphologically altered structure NA BeFree Detail
<0.001 sarcoma NA BeFree Detail
<0.001 attention deficit hyperactivity disorder NA BeFree Detail
<0.001 Enterochromaffin-like cell carcinoid NA BeFree Detail
<0.001 Atypical teratoid/rhabdoid tumor NA BeFree Detail
<0.001 Chronic myeloproliferative disorder Herein, we will review the clinically relevant inhibitors of the PI3K pathway th... BeFree 26062813 Detail
<0.001 Pancreatic intraepithelial neoplasia NA BeFree Detail
<0.001 Salivary duct carcinoma NA BeFree Detail
<0.001 Sendai virus infection Our results show that Sendai virus infection, which is recognized by RIG-I, led ... BeFree 25158146 Detail
<0.001 Hormone refractory prostate cancer NA BeFree Detail
<0.001 Classical Hodgkin's Lymphoma NA BeFree Detail
<0.001 Epstein-Barr Virus-Related Lymphoma NA BeFree Detail
<0.001 External Auditory Canal Ceruminous Adenoma NA BeFree Detail
<0.001 Testicular Germ Cell Tumor NA BeFree Detail
<0.001 differentiated thyroid gland carcinoma NA BeFree Detail
<0.001 Granulosa cell tumor of the ovary NA BeFree Detail
0.001 renal carcinoma Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-indu... BeFree 24743574 Detail
<0.001 Metastatic Carcinoma Targeted PI3K/AKT/mTOR therapy for metastatic carcinomas of the cervix: A phase ... BeFree 25426553 Detail
0.006 Mammary Neoplasms We validated the top ranking genes, i.e., PIK3CA and PIK3CB, by showing that the... BeFree,LHGDN 25195596 Detail
<0.001 Angiogenic Switch NA BeFree Detail
<0.001 Hepatocarcinogenesis NA BeFree Detail
0.001 Cancer Cell Growth NA BeFree Detail
0.002 Tumor Angiogenesis The tumor suppressor WIF1 was also found to be capable of suppressing tumor grow... BeFree 25086206 Detail
0.002 Tumor Angiogenesis Increased CYP4Z2P- and CYP4Z1-3'UTR expression promotes tumor angiogenesis in br... BeFree 25701119 Detail
<0.001 Tumor Promotion NA BeFree Detail
0.002 Xenograft Model The combination of HER2 inhibitors with PI3K inhibition was studied in HER2-ampl... BeFree 24451154 Detail
0.002 Xenograft Model Using AR + TNBC cell line and xenograft models we evaluated the effectiveness of... BeFree 25103565 Detail
0.002 Xenograft Model In addition, the phosphoinositide-3-kinase (PI3K)/Akt/mammalian target of rapamy... BeFree 25153728 Detail
0.002 Xenograft Model We tested the in vivo efficacy of three PI3K inhibitors (PI3Ki) in patient-deriv... BeFree 25316817 Detail
0.012 colorectal cancer The added predictive value of additional biomarkers in the RAS-RAF-MAPK and PI3K... BeFree 24666267 Detail
0.012 colorectal cancer The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer. BeFree 25023051 Detail
0.012 colorectal cancer These data indicate that the capacity of retinol to inhibit PI3K activity confer... BeFree 25356626 Detail
0.012 colorectal cancer We conclude that cPLA2α is required for sustaining AKT phosphorylation at Ser473... BeFree 25365190 Detail
0.012 colorectal cancer Inhibitors against KRAS signaling mediators, namely, PI3K (phosphatidylinositol ... BeFree 25389372 Detail
0.012 colorectal cancer PTEN inactivation by mutation or allelic loss also occurs in CRCs. miR‑135b was ... BeFree 25571954 Detail
0.012 colorectal cancer The role of the PI3K pathway in colorectal cancer. BeFree 25591826 Detail
0.012 colorectal cancer Mutations in the RAS and PI3K pathways are associated with metastatic location i... BeFree 25920435 Detail
0.012 colorectal cancer Eight of these genes were linked to the Wnt, Hippo, TGF-β, EGF receptor, or PI3K... BeFree 26056301 Detail
<0.001 Rash and Dermatitis Adverse Event Associated with Chemoradiation NA BeFree Detail
<0.001 Adenocarcinoma, Endometrioid Preclinical investigations have suggested that the PI3K/AKT/mTOR pathway is freq... BeFree 25677064 Detail
0.001 Glioblastoma multiforme Here, using specific inhibitors, we found that the activation of EGFR signaling ... BeFree 25431263 Detail
0.001 Glioblastoma multiforme The phosphoinositide 3-kinase (PI3K)/Akt/PTEN signaling pathway is deregulated i... BeFree 25501707 Detail
<0.001 Cirrhosis NA BeFree Detail
<0.001 androgen independent prostate cancer NA BeFree Detail
<0.001 tumor vasculature Important mechanisms we discuss include (1) improved DNA repair in normal, but n... BeFree 24436017 Detail
<0.001 Idiopathic Pulmonary Fibrosis NA BeFree Detail
<0.001 Familial ependymoma NA BeFree Detail
<0.001 ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1 Although the mutation rates and mutational signatures of MSS and MSI-H EECs were... BeFree 25701704 Detail
<0.001 Prostate Cancer, Hereditary, 7 NA BeFree Detail
<0.001 Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome NA BeFree Detail
0.006 uterine corpus cancer The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal tra... BeFree 25141911 Detail
0.006 uterine corpus cancer This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pa... BeFree 25301678 Detail
0.006 uterine corpus cancer The phosphoinositol-3 kinase (PI3K) pathway is frequently dysregulated in endome... BeFree 25624430 Detail
0.006 uterine corpus cancer NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activat... BeFree 26193427 Detail
<0.001 PTEN hamartoma tumor syndrome NA BeFree Detail
<0.001 Philadelphia chromosome-positive acute lymphoblastic leukemia NA BeFree Detail
0.004 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma In this review, we summarize the existing knowledge of the relevance of Notch1 a... BeFree 24819383 Detail
0.004 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma We also explored the molecular mechanism of FHL1C overexpression-induced apoptos... BeFree 24952875 Detail
0.004 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma High activation of the PI3K-AKT-mTOR pathway is characteristic for T-cell acute ... BeFree 25241901 Detail
0.002 Precursor Cell Lymphoblastic Leukemia Lymphoma NA BeFree Detail
<0.001 Urothelial Carcinoma NA BeFree Detail
0.014 liver carcinoma This mode of action for calycopterin in our study provides strong support that i... BeFree 25060910 Detail
0.014 liver carcinoma The PI3K/Akt/Snail-dependent pathway may mediate the pro-invasive and pro-metast... BeFree 25070581 Detail
0.014 liver carcinoma The inhibition of PI3K/Akt activation abolished epithelial-mesenchymal transitio... BeFree 25087096 Detail
0.014 liver carcinoma Bioinformatic method was applied to predict the binding of miR-218 on HoxA10, an... BeFree 25120782 Detail
0.014 liver carcinoma In clinical HCC samples, high expression of both CXCR2 and CXCL5 showed a signif... BeFree 25462858 Detail
0.014 liver carcinoma The purpose of this study was to determine the impact of sorafenib on PI3K/AKT/m... BeFree 25778319 Detail
0.014 liver carcinoma HBx induced AFP receptor expressed to activate PI3K/AKT signal to promote expres... BeFree 25943101 Detail
0.014 liver carcinoma Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/m... BeFree 26055238 Detail
0.014 liver carcinoma Moreover, LIFR knockdown could activate phosphoinositide 3-kinase/V-akt Murine T... BeFree 26249360 Detail
<0.001 Oropharyngeal Carcinoma NA BeFree Detail
<0.001 Allergic rhinitis (disorder) NA BeFree Detail
<0.001 Thrombotic Microangiopathies NA BeFree Detail
<0.001 Macroencephaly NA BeFree Detail
<0.001 Kashin-Beck Disease Role of selenoprotein S (SEPS1) -105G>A polymorphisms and PI3K/Akt signaling pat... BeFree 25433273 Detail
<0.001 Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma NA BeFree Detail
<0.001 Chronic ulcerative colitis NA BeFree Detail
<0.001 Benign symmetrical lipomatosis NA BeFree Detail
0.003 Nasopharyngeal carcinoma Epigenetic inactivation of inositol polyphosphate 4-phosphatase B (INPP4B), a re... BeFree 25126743 Detail
0.003 Nasopharyngeal carcinoma The current study demonstrated that EphA2 mediates sensitivity to paclitaxel via... BeFree 25351620 Detail
<0.001 aggressive cancer NA BeFree Detail
<0.001 Fetal Alcohol Spectrum Disorders NA BeFree Detail
<0.001 Overgrowth syndrome Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, are ... BeFree 25550458 Detail
<0.001 Stage II Colon Cancer AJCC v7 NA BeFree Detail
<0.001 Primary acquired melanosis The PI3K/AKT/mTOR (PAM) signaling pathway controls key cellular responses, such ... BeFree 25601471 Detail
<0.001 myelodysplastic syndrome NA BeFree Detail
0.003 Triple Negative Breast Neoplasms Different targeted therapies may be necessary for TNBC that involves activation ... BeFree 25009009 Detail
0.003 Triple Negative Breast Neoplasms PIK3CA mutations in androgen receptor-positive triple negative breast cancer con... BeFree 25103565 Detail
0.003 Triple Negative Breast Neoplasms Mutational profiles in triple-negative breast cancer defined by ultradeep multig... BeFree 25296970 Detail
0.003 Triple Negative Breast Neoplasms β-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in tripl... BeFree 25721419 Detail
<0.001 ESTROGEN RESISTANCE Activation of the phosphatidylinositol-3-kinase (PI3K) and/or mitogen-activated ... BeFree 24447434 Detail
<0.001 ESTROGEN RESISTANCE Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway has been... BeFree 25491778 Detail
<0.001 Experimental Organism Basal Cell Carcinoma NA BeFree Detail
<0.001 Congenital Abnormality Brain overgrowth in disorders of RTK-PI3K-AKT signaling: a mosaic of malformatio... BeFree 25432429 Detail
0.002 adenocarcinoma NA BeFree Detail
<0.001 Primary myelofibrosis NA BeFree Detail
<0.001 Alcoholic Intoxication, Chronic NA BeFree Detail
<0.001 Alzheimer's disease NA BeFree Detail
<0.001 arteriosclerosis NA BeFree Detail
0.002 rheumatoid arthritis Following stimulation with 10 nM insulin for 30 min, the stable overexpression o... BeFree 25760103 Detail
<0.001 asthma NA BeFree Detail
<0.001 Astrocytoma NA BeFree Detail
<0.001 atherosclerosis NA BeFree Detail
<0.001 autistic disorder NA BeFree Detail
<0.001 Autoimmune Diseases NA BeFree Detail
0.002 Barrett esophagus NA GAD Detail
0.004 Malignant neoplasm of urinary bladder These findings may have high relevance in terms of using PI3K-targeted therapies... BeFree 24347284 Detail
0.004 Malignant neoplasm of urinary bladder Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential us... BeFree 24929024 Detail
0.004 Malignant neoplasm of urinary bladder Our findings suggest that miR-21 acts as a molecular switch to regulate aerobic ... BeFree 25266796 Detail
0.004 Malignant neoplasm of urinary bladder Taken together, EN2 may be a candidate oncogene in BC by activating the PI3K/Akt... BeFree 25812440 Detail
0.001 Brain Neoplasms NA BeFree Detail
0.047 Malignant neoplasm of breast Direct inhibition of PI3K in combination with dual HER2 inhibitors is required f... BeFree,GAD 24451154 Detail
0.047 Malignant neoplasm of breast Characterization of breast cancers with PI3K mutations in an academic practice s... BeFree,GAD 24722917 Detail
0.047 Malignant neoplasm of breast Their prognostic value and that of the phosphatidylinositol 3-kinase (PI3K) path... BeFree,GAD 24981670 Detail
0.047 Malignant neoplasm of breast Phosphatidylinositol 3-kinase (PI3K) pathway deregulation (that is PIK3CA mutati... BeFree,GAD 25056500 Detail
0.047 Malignant neoplasm of breast Western blot analysis data indicate that MAPK/ERK and PI3K/Akt signaling in brea... BeFree,GAD 25127034 Detail
0.047 Malignant neoplasm of breast Microarray phosphatome profiling of breast cancer patients unveils a complex pho... BeFree,GAD 25201346 Detail
0.047 Malignant neoplasm of breast In the present study, we have shown for the first time that HBA decreased the ex... BeFree,GAD 25299784 Detail
0.047 Malignant neoplasm of breast Axl as a downstream effector of TGF-β1 via PI3K/Akt-PAK1 signaling pathway promo... BeFree,GAD 25327287 Detail
0.047 Malignant neoplasm of breast Regulation of the cell cycle and PI3K/Akt/mTOR signaling pathway by tanshinone I... BeFree,GAD 25355053 Detail
0.047 Malignant neoplasm of breast LYN(D189Y) overexpression abrogated growth inhibition by fulvestrant and/or the ... BeFree,GAD 25401474 Detail
0.047 Malignant neoplasm of breast Phosphatidylinositol-3-kinase (PI3K)/AKT pathway mutations are associated with c... BeFree,GAD 25422220 Detail
0.047 Malignant neoplasm of breast The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrin... BeFree,GAD 25491778 Detail
0.047 Malignant neoplasm of breast In conclusion, activating the PI3K pathway is associated with low pCR to trastuz... BeFree,GAD 25542038 Detail
0.047 Malignant neoplasm of breast Estrogen-responsive genes most significantly influenced by cohesin were enriched... BeFree,GAD 25542856 Detail
0.047 Malignant neoplasm of breast BYL719, which selectively inhibits the alpha isoform of the phosphatidylinositol... BeFree,GAD 25544637 Detail
0.047 Malignant neoplasm of breast We investigated whether mutations in the gene encoding the phosphatidylinositol ... BeFree,GAD 25559818 Detail
0.047 Malignant neoplasm of breast In the present study, we demonstrate that PI3K pathway regulates phenotypic chan... BeFree,GAD 25643809 Detail
0.047 Malignant neoplasm of breast Further, PI3K is thought to be the main driver of lapatinib resistance, but our ... BeFree,GAD 25692408 Detail
0.047 Malignant neoplasm of breast The epidermal growth factor receptor (EGFR)/PI3K/AKT signaling pathway aberratio... BeFree,GAD 25702787 Detail
0.047 Malignant neoplasm of breast In the present study, the protein expression levels of SET, protein phosphatase ... BeFree,GAD 25760096 Detail
0.047 Malignant neoplasm of breast PI3K inhibition results in enhanced estrogen receptor function and dependence in... BeFree,GAD 25877889 Detail
0.047 Malignant neoplasm of breast IL-8/PI3K/Akt/NF-κB/integrin β3 axis may be exploited for therapeutic interventi... BeFree,GAD 25979232 Detail
0.047 Malignant neoplasm of breast Beyond ER and HER2, BRCA and PIK3CA mutations (when targeted with alpha-specific... BeFree,GAD 25993174 Detail
0.047 Malignant neoplasm of breast Taken together, the prostacyclin/IP/PI3K-p38 MAPK axis has emerged as a novel pr... BeFree,GAD 26067757 Detail
0.047 Malignant neoplasm of breast Resistance to trastuzumab in patients with HER2-overexpressing breast cancer is ... BeFree,GAD 26247526 Detail
0.047 Malignant neoplasm of breast Collectively, our findings identify PIPP as a suppressor of oncogenic PI3K/AKT s... BeFree,GAD 26267533 Detail
0.047 Malignant neoplasm of breast Inhibition of Autophagy Increases Proliferation Inhibition and Apoptosis Induced... BeFree,GAD 26427150 Detail
<0.001 Burkitt lymphoma NA BeFree Detail
<0.001 Carcinoid Tumor NA BeFree Detail
0.007 Malignant tumor of colon Synergism of PI3K/Akt inhibition and Fas activation on colon cancer cell death. BeFree 25199763 Detail
0.007 Malignant tumor of colon Quinazoline based small molecule exerts potent tumour suppressive properties by ... BeFree 25554016 Detail
0.007 Malignant tumor of colon In the present study, the expression status of miR-218 and the role of the phosp... BeFree 25760926 Detail
0.007 Malignant tumor of colon Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway gene... BeFree 25889965 Detail
0.007 Malignant tumor of colon Here, we detected its effects on DLD-1 and SW480 (two human colon cancer cell li... BeFree 26225471 Detail
0.006 Malignant neoplasm of endometrium The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal tra... BeFree 25141911 Detail
0.006 Malignant neoplasm of endometrium This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pa... BeFree 25301678 Detail
0.006 Malignant neoplasm of endometrium The phosphoinositol-3 kinase (PI3K) pathway is frequently dysregulated in endome... BeFree 25624430 Detail
0.006 Malignant neoplasm of endometrium NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activat... BeFree 26193427 Detail
<0.001 Rectal Carcinoma The phosphatidylinositol 3-kinase (PI3K), MAP kinase (MAPK), and related pathway... BeFree 24700299 Detail
0.006 Malignant neoplasm of thyroid NA BeFree Detail
<0.001 Noninfiltrating Intraductal Carcinoma PI3K pathway activation in high-grade ductal carcinoma in situ--implications for... BeFree 24634376 Detail
<0.001 Merkel cell carcinoma NA BeFree Detail
0.012 Non-small cell lung carcinoma In conclusion, the positive feedback loop between NOX4 and PI3K/Akt signaling co... BeFree 24946933 Detail
0.012 Non-small cell lung carcinoma We have recently shown that Semaphorin 4B (SEMA4B) inhibits the invasion of non-... BeFree 25746385 Detail
0.012 Non-small cell lung carcinoma ILT4 drives B7-H3 expression via PI3K/AKT/mTOR signalling and ILT4/B7-H3 co-expr... BeFree 26149216 Detail
Annotation

Annotations

DescrptionSourceLinks
Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in hum... DisGeNET Detail
We genotyped 70 genes involved in the pathogenesis of renal-cell carcinoma (including the VHL/HIF/VE... DisGeNET Detail
The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway has been identified as an import... DisGeNET Detail
PI3Kβ inhibitor TGX221 selectively inhibits renal cell carcinoma cells with both VHL and SETD2 mutat... DisGeNET Detail
Taken together, our findings indicate that ghrelin can activate Snail function via the GHS-R-PI3K-Ak... DisGeNET Detail
Importantly, the level of miR-508 correlates with poor survival and activated PI3K/Akt signalling in... DisGeNET Detail
Moreover, blocking the whole PI3K-AKT-mTOR pathway with the PI3K/mTOR dual inhibitor BEZ235 also sho... DisGeNET Detail
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Taken together, our data suggest that anti-VEGFa treatment in cervical cancer may inhibit both tumor... DisGeNET Detail
CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer. DisGeNET Detail
Peroxisome proliferator-activated receptor-gamma agonist 4-O-methylhonokiol induces apoptosis by tri... DisGeNET Detail
The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein is principally involved i... DisGeNET Detail
Butein suppresses cervical cancer growth through the PI3K/AKT/mTOR pathway. DisGeNET Detail
In cells infected with the closely related chikungunya virus (CHIKV), the PI3K-Akt-mTOR pathway was ... DisGeNET Detail
Stimulation of chondrosarcoma with CCL5 augmented PI3K and Akt phosphorylation, while PI3K and Akt i... DisGeNET Detail
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In acute myeloid leukemia (AML), several signaling pathways such as the phosphatidylinositol-3-kinas... DisGeNET Detail
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The added predictive value of additional biomarkers in the RAS-RAF-MAPK and PI3K-AKT-mTOR pathways i... DisGeNET Detail
The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer. DisGeNET Detail
These data indicate that the capacity of retinol to inhibit PI3K activity confers its ability to dec... DisGeNET Detail
We conclude that cPLA2α is required for sustaining AKT phosphorylation at Ser473 and cell proliferat... DisGeNET Detail
Inhibitors against KRAS signaling mediators, namely, PI3K (phosphatidylinositol 3-kinase) and mTOR (... DisGeNET Detail
PTEN inactivation by mutation or allelic loss also occurs in CRCs. miR‑135b was reported to be upreg... DisGeNET Detail
The role of the PI3K pathway in colorectal cancer. DisGeNET Detail
Mutations in the RAS and PI3K pathways are associated with metastatic location in colorectal cancers... DisGeNET Detail
Eight of these genes were linked to the Wnt, Hippo, TGF-β, EGF receptor, or PI3K pathways, all invol... DisGeNET Detail
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bFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reper... DisGeNET Detail
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Effects of D-Pinitol on Insulin Resistance through the PI3K/Akt Signaling Pathway in Type 2 Diabetes... DisGeNET Detail
Podocyte-specific genetic ablation of XBP1 or inducible expression of ATF6 in mice aggravates DN. sX... DisGeNET Detail
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Therefore, concomitant blockage of the ErbB2-PI3K pathway and the Hedgehog downstream mediator Gli-1... DisGeNET Detail
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Moreover, TRIM24 regulates the expression of DNA repair enzyme O(6)-methylguanine-DNA methyltransfer... DisGeNET Detail
ABT-263 (Navitoclax), an orally available small-molecule Bcl-2 inhibitor, and GDC-0941, a PI3K inhib... DisGeNET Detail
In this study, we used inhibitors to block specific signaling pathways, including JAK, PI3K/Akt, and... DisGeNET Detail
Application of a specific extracellular-related kinase 1/2 (ERK1/2) inhibitor, but not application o... DisGeNET Detail
However, due to the development of resistance mechanisms, kinase inhibition studies targeting the PI... DisGeNET Detail
The EGFR and PI3K/mTORC1/2 pathways are frequently altered in glioblastoma (GBM), but pharmacologic ... DisGeNET Detail
The activation of PI3K/Akt1 signaling pathway is involved in the proliferation of glioblastoma; howe... DisGeNET Detail
Further analyses revealed that Cyr61 seemed to activate PI3K/Akt/mTor signaling pathway to increase ... DisGeNET Detail
TRIM24 promotes glioma progression and enhances chemoresistance through activation of the PI3K/Akt s... DisGeNET Detail
These results suggest that Liq treatment enhances glioma cell susceptibility to TMZ by inhibiting th... DisGeNET Detail
Several studies have attempted to investigate the effects of combining the inhibition of both PI3K a... DisGeNET Detail
The loss of MAGI3 expression in glioma may enhance the proliferation of glioma cells via downregulat... DisGeNET Detail
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This article highlights recent progress in characterizing the molecular mechanisms of PI3K isoform-s... DisGeNET Detail
This novel mechanism of Dlg1 subversion by adenovirus to dysregulate PI3K could be used by other pat... DisGeNET Detail
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In this study, we examined the effect of Ginsenoside Rb1 (GRb1) on ischemia/reperfusion-induced auto... DisGeNET Detail
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In the present study, we have shown for the first time that HBA decreased the expression of phosphot... DisGeNET Detail
The PI3K/Akt signaling pathway is constitutively activated in various leukemias. DisGeNET Detail
Altogether, these results underline the key role of PI3K/AKT pathway in the generation of the CLL pr... DisGeNET Detail
The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signa... DisGeNET Detail
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Importantly, emodin was demonstrated as a new inhibitor of PI3K/Akt in AML cells, even in primary AM... DisGeNET Detail
Inhibiting rescue pathways could improve the therapeutic efficacy of PI3K-targeted therapies in AML. DisGeNET Detail
In the primary AML sample, we investigated the cell responses to ex vivo stimulation with stem cell ... DisGeNET Detail
The Ras/Raf/MAPK and PI3K/Akt/mTOR pathways are key signaling cascades involved in the regulation of... DisGeNET Detail
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The fusion gene bcr-abl develops chronic myeloid leukemia (CML), and stimulates PI3K/Akt/mTOR signal... DisGeNET Detail
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HBx induced AFP receptor expressed to activate PI3K/AKT signal to promote expression of Src in liver... DisGeNET Detail
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In conclusion, knockdown of the c‑Met gene promoted gastric cancer cell apoptosis and inhibited down... DisGeNET Detail
Mechanically, PTP1B promotes gastric cancer cell proliferation, survival and invasiveness through mo... DisGeNET Detail
Therefore, our studies reveal for the first time that inhibition of the PI3K-Akt pathway is involved... DisGeNET Detail
Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-κB signaling pa... DisGeNET Detail
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Targeting the PI3K/AKT/mTOR signaling pathway in medulloblastoma. DisGeNET Detail
The impact of RNA interference (RNAi)-mediated silencing of PI3K isoforms p110α and p110δ on global ... DisGeNET Detail
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Recent attention has focused on the role of phosphatidylinositol 3-kinase (PI3K) in both immune and ... DisGeNET Detail
Cancers like multiple myeloma (MM), which display elevated activity in key translation regulatory no... DisGeNET Detail
Furthermore, our results demonstrated that the enforced expression of miR-145 in H929 cells profound... DisGeNET Detail
Previously we showed that tetraspanin overexpression in MM cell lines attenuated mTOR and PI3K casca... DisGeNET Detail
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In situ assessment of PI3K and PTEN alterations in mycosis fungoides: correlation with clinicopathol... DisGeNET Detail
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Herein, we will review the clinically relevant inhibitors of the PI3K pathway that have been evaluat... DisGeNET Detail
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Mechanistically, knockdown of FAP inactivated PTEN/PI3K/AKT and Ras-ERK and its downstream signaling... DisGeNET Detail
IL-7 splicing variant IL-7δ5 induces EMT and metastasis of human breast cancer cell lines MCF-7 and ... DisGeNET Detail
Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3... DisGeNET Detail
However, the mechanisms and specific functions of PI3K isoforms in tumor invasion and metastasis are... DisGeNET Detail
NOX4 promotes non-small cell lung cancer cell proliferation and metastasis through positive feedback... DisGeNET Detail
Yet, little is known concerning the role of the PI3K/Akt/Snail-dependent pathway in sorafenib‑induce... DisGeNET Detail
First-in-human study of CH5132799, an oral class I PI3K inhibitor, studying toxicity, pharmacokineti... DisGeNET Detail
Overexpression of ribonuclease inhibitor defines good prognosis and suppresses proliferation and met... DisGeNET Detail
These data indicate that the capacity of retinol to inhibit PI3K activity confers its ability to dec... DisGeNET Detail
These findings suggest that CEACAM6 enhances invasion and metastasis in GC by promoting EMT via the ... DisGeNET Detail
These findings indicated that MALAT1 might suppress the tumor growth and metastasis via PI3K/AKT sig... DisGeNET Detail
In conclusion, this study suggested that EMT process can be triggered by the BMP2/BMPR axis in gastr... DisGeNET Detail
The EGFR/PI3K/PTEN/Akt/mTORC pathway plays prominent roles in malignant transformation, prevention o... DisGeNET Detail
SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallblad... DisGeNET Detail
The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway plays a cr... DisGeNET Detail
Together, these results demonstrate that HGF/c-met can activate PI3K/Akt and downstream NF-κB signal... DisGeNET Detail
Mechanistic studies further revealed that VAV3 overexpression could dysregulate the expression of ce... DisGeNET Detail
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We suggest that Nutlin-3, possibly in combination with FAK or PI3K inhibitors, can be employed as a ... DisGeNET Detail
Moreover, inhibitors of PI3K/mTOR and GLI signaling reduced neuroblastoma cell growth, but no additi... DisGeNET Detail
Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib i... DisGeNET Detail
We previously demonstrated that PI3K Class IIβ (PI3KC2β) and its regulator intersectin 1 (ITSN1) are... DisGeNET Detail
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This integrated view of PI3K functions may ultimately help to develop new therapeutic interventions ... DisGeNET Detail
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Knockdown of CXCR7 suppressed proliferation and invasion of OS cells through decreased expression of... DisGeNET Detail
The present results indicated that LY294002 inhibits the malignant phenotype of OS cells via modulat... DisGeNET Detail
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteos... DisGeNET Detail
In conclusion, icariin possesses a reversal effect on multidrug resistance in MG-63/DOX cells throug... DisGeNET Detail
Re-expression of ARHI in ovarian cancer cells blocks signaling through the PI3K and Ras/MAP pathways... DisGeNET Detail
MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the P... DisGeNET Detail
Inhibiting the PI3K/AKT pathway may be a useful treatment for ovarian carcinoma. DisGeNET Detail
Moreover, LY294002, a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinases... DisGeNET Detail
The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer. DisGeNET Detail
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In type 2 diabetes, obesity and PCOS, there is, although with some variation from study to study, de... DisGeNET Detail
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PTEN inactivation by mutation or allelic loss also occurs in CRCs. miR‑135b was reported to be upreg... DisGeNET Detail
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Genome-wide analyses have identified four major signaling nodes that are most frequently altered in ... DisGeNET Detail
PIK3R3, an isoform of class IA phosphoinositide 3-kinase (PI3K), specifically interacts with cell pr... DisGeNET Detail
In the present study, we searched for combination therapies with the dual PI3K/mTOR inhibitor NVP-BE... DisGeNET Detail
Thus, combined GLI1/2 and PI3K/mTOR inhibition represents a promising novel approach for synergistic... DisGeNET Detail
The aim of our study was to investigate whether common polymorphisms in the genes regulating the ear... DisGeNET Detail
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These data are the first to demonstrate that the inflammatory response induced by IL-1β promotes sei... DisGeNET Detail
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We have already shown that AKT is activated in skin lesions in Mycosis Fungoides (MF) and we herein ... DisGeNET Detail
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In conclusion, IL-8 stimulates VEGF production in hBM-MSCs in part via the PI3K/Akt and MAPK/ERK sig... DisGeNET Detail
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In addition, the phosphoinositide-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway w... DisGeNET Detail
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The phosphatidylinositol-3-kinase (PI3K) and Akt pathway is activated in host immune cells upon vira... DisGeNET Detail
Many alterations directly or indirectly lead to activation of survival signaling pathways and expres... DisGeNET Detail
The oncogenic PI3K/serine-threonine kinase (PI3K/AKT) pathway is a downstream pathway of B-cell rece... DisGeNET Detail
Inhibition of the PI3K/Akt/mTOR signaling pathway in diffuse large B-cell lymphoma: current knowledg... DisGeNET Detail
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We suggest that targeting the PI3K/AKT pathway may be a promising therapeutic strategy for PTCL. DisGeNET Detail
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This study reveals a critical role for the PTEN/PI3K pathway in both SCLC and lung adenocarcinoma an... DisGeNET Detail
The PI3K/AKT/mTOR pathway is distinguishable in SCLC genomic alterations. DisGeNET Detail
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bFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reper... DisGeNET Detail
These data identify RIT1 as a driver oncogene in a specific subset of lung adenocarcinomas and sugge... DisGeNET Detail
This study reveals a critical role for the PTEN/PI3K pathway in both SCLC and lung adenocarcinoma an... DisGeNET Detail
ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas. DisGeNET Detail
Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis... DisGeNET Detail
Therefore, concomitant blockage of the ErbB2-PI3K pathway and the Hedgehog downstream mediator Gli-1... DisGeNET Detail
Immunohistochemical and molecular analysis of PI3K/AKT/mTOR pathway in esophageal carcinoma. DisGeNET Detail
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We found that activation of the PI3K/Akt pathway was involved in the oncogenic functions of SPOCK1 i... DisGeNET Detail
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We propose the simultaneous activation of PLC-PKC-MEK1/2-ERK1/2 and PI3K pathways as the main mechan... DisGeNET Detail
These findings uncover a mechanism for constitutive PI3K/Akt activation in ESCC, and support a funct... DisGeNET Detail
Our data showed that the PTEN/PI3K pathway was active in human ESCC tissues in vivo, particularly in... DisGeNET Detail
The PI3K/AKT signal transduction pathway has distinct functional roles in tumor progression. DisGeNET Detail
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In addition to the commonly known AP-1 activators Mitogen-Activated Protein Kinases (MAPKs), there a... DisGeNET Detail
Anticancer effect of calycopterin via PI3K/Akt and MAPK signaling pathways, ROS-mediated pathway and... DisGeNET Detail
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Crosstalk between PI3K and Ras pathways via protein phosphatase 2A in human ovarian clear cell carci... DisGeNET Detail
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Preclinical investigations have suggested that the PI3K/AKT/mTOR pathway is frequently activated in ... DisGeNET Detail
The efficacy of both PI3K and MEK inhibitors was evaluated in a model of endometrioid carcinoma harb... DisGeNET Detail
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Neuroendocrine cancer cell lines are used to investigate therapeutic targets in neuroendocrine tumor... DisGeNET Detail
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We found that activation of the PI3K/Akt pathway was involved in the oncogenic functions of SPOCK1 i... DisGeNET Detail
Further analysis showed that Cyr61 seemed to activate phosphatidylinositol 3-kinase (PI3K) but not e... DisGeNET Detail
Recent data identify 3-phosphoinositide-dependent protein kinase 1 as a key tumour-initiating event ... DisGeNET Detail
Activation of phosphoinositide-3 kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway play... DisGeNET Detail
Taken together, these data indicate that inhibition of MEK and PI3K alone or in combination with che... DisGeNET Detail
microRNA-218 increase the sensitivity of gastrointestinal stromal tumor to imatinib through PI3K/AKT... DisGeNET Detail
We tested the in vivo efficacy of three PI3K inhibitors (PI3Ki) in patient-derived GIST xenograft mo... DisGeNET Detail
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Here, we outlined the common pathways that are altered in ATC, including the BRAF(V600E)/ERK1/2-MEK1... DisGeNET Detail
PI3K/Akt/mTOR: A promising therapeutic target for non-medullary thyroid carcinoma. DisGeNET Detail
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RNA interference-mediated knockdown of RhoGDI2 induces the migration and invasion of human lung canc... DisGeNET Detail
Common molecular drivers of lung cancer are mutations in receptor tyrosine kinases (RTKs) leading to... DisGeNET Detail
When the chimeric ubiquitin ligases were introduced into lung cancer SPC-A1 cells, they effectively ... DisGeNET Detail
The altered PI3K/mTOR pathway is implicated in lung cancer, but mTOR inhibitors have failed to demon... DisGeNET Detail
It was found that AKT1 and PI3K/p85 expression was upregulated in LCSCs compared with that in the pr... DisGeNET Detail
Hepatocyte growth factor (HGF) induces resistance to reversible and irreversible epidermal growth fa... DisGeNET Detail
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Genome-wide analyses have identified four major signaling nodes that are most frequently altered in ... DisGeNET Detail
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Here, resistance to a class I PI3K inhibitor in a model of metastatic breast cancer driven by PI3K a... DisGeNET Detail
Molecular aberrations affecting the PI3K pathway may play a role in the progression from high-grade ... DisGeNET Detail
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Activation of the PI3K/AKT signal pathway is a known driving force for the progression to castration... DisGeNET Detail
Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in met... DisGeNET Detail
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Our studies indicate that CK2-mediated PTEN posttranslational inactivation, associated with PI3K/Akt... DisGeNET Detail
Disruption of the PTEN/PI3K pathway involved in TGF-β1-induced EMT may provide possible routes for t... DisGeNET Detail
Notably, high activity of hedgehog signaling and the PI3K pathway in approximately 60% of 104 ESCC t... DisGeNET Detail
Dasatinib enhances cisplatin sensitivity in human esophageal squamous cell carcinoma (ESCC) cells vi... DisGeNET Detail
ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: iden... DisGeNET Detail
The objective of this study was to investigate the predictive value of common genetic alterations of... DisGeNET Detail
Loss of MLH1 confers resistance to PI3Kβ inhibitors in renal clear cell carcinoma with SETD2 mutatio... DisGeNET Detail
We identified the selective PI3Kβ inhibitor TGX221 as a selective inhibitor for ccRCC with both VHL ... DisGeNET Detail
High selectivity of PI3Kβ inhibitors in SETD2-mutated renal clear cell carcinoma. DisGeNET Detail
First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-k... DisGeNET Detail
BYL719, which selectively inhibits the alpha isoform of the phosphatidylinositol 3-kinase (PI3K) cat... DisGeNET Detail
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Taken together, our data suggest that anti-VEGFa treatment in cervical cancer may inhibit both tumor... DisGeNET Detail
CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer. DisGeNET Detail
Peroxisome proliferator-activated receptor-gamma agonist 4-O-methylhonokiol induces apoptosis by tri... DisGeNET Detail
The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein is principally involved i... DisGeNET Detail
Butein suppresses cervical cancer growth through the PI3K/AKT/mTOR pathway. DisGeNET Detail
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In this study, the inhibitory effect of KYNA on activation of phosphoinositide 3-kinase/Akt (PI3K/Ak... DisGeNET Detail
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Recent data identify 3-phosphoinositide-dependent protein kinase 1 as a key tumour-initiating event ... DisGeNET Detail
Activation of phosphoinositide-3 kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway play... DisGeNET Detail
Taken together, these data indicate that inhibition of MEK and PI3K alone or in combination with che... DisGeNET Detail
First-in-human study of CH5132799, an oral class I PI3K inhibitor, studying toxicity, pharmacokineti... DisGeNET Detail
Juvenile myelomonocytic leukaemia-associated mutation in Cbl promotes resistance to apoptosis via th... DisGeNET Detail
We identified differential therapeutic vulnerabilities that emerge upon the loss of both PTEN and p5... DisGeNET Detail
A genome-wide RNAi screen identifies FOXO4 as a metastasis-suppressor through counteracting PI3K/AKT... DisGeNET Detail
The impact of miRNA on the canonical TGF-β Smad signalling pathway has been well investigated, hence... DisGeNET Detail
Restoration of PTEN expression or inhibition of PI3K action decreased cPLA₂α expression in PTEN-muta... DisGeNET Detail
Genome-wide analyses have identified four major signaling nodes that are most frequently altered in ... DisGeNET Detail
Targeting the PI3K/Akt pathway in prostate cancer: challenges and opportunities (review). DisGeNET Detail
The findings from this study suggest that the combination of dual PI3K/Akt/mTOR inhibitors (BEZ235 o... DisGeNET Detail
Co-targeting AR and PI3K/AKT signaling has been proposed to be a more effective therapeutic means fo... DisGeNET Detail
The Upregulation of PI3K/Akt and MAP Kinase Pathways is Associated with Resistance of Microtubule-Ta... DisGeNET Detail
Among the cancer networks and STNs we considered, it is found that there is a substantial amount of ... DisGeNET Detail
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The activation of a central growth/survival pathway (PI3K/AKT) represents a feasible target for the ... DisGeNET Detail
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Endometrial cancers have been recently molecularly characterized; amplifications of human epidermal ... DisGeNET Detail
The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer s... DisGeNET Detail
This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pathway inhibitors in ... DisGeNET Detail
The phosphoinositol-3 kinase (PI3K) pathway is frequently dysregulated in endometrial cancer (EC). DisGeNET Detail
PIKing the type and pattern of PI3K pathway mutations in endometrioid endometrial carcinomas. DisGeNET Detail
NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt s... DisGeNET Detail
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Other molecular alterations, like mTOR or PI3K pathway deregulation, or Matrilin 2 overexpression, m... DisGeNET Detail
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Therefore, concomitant blockage of the ErbB2-PI3K pathway and the Hedgehog downstream mediator Gli-1... DisGeNET Detail
The present review focuses on the most recent developments on the role of the PI3K/Akt pathway in th... DisGeNET Detail
We further show that expression of PTEN, a well-established, potent tumor suppressor, is lost in a s... DisGeNET Detail
Y-box Binding Protein-1 Is Part of a Complex Molecular Network Linking ΔNp63α to the PI3K/akt Pathwa... DisGeNET Detail
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Divergence of P53, PTEN, PI3K, Akt and mTOR expression in tonsillar cancer. DisGeNET Detail
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Knockdown of CXCR7 suppressed proliferation and invasion of OS cells through decreased expression of... DisGeNET Detail
The present results indicated that LY294002 inhibits the malignant phenotype of OS cells via modulat... DisGeNET Detail
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteos... DisGeNET Detail
In conclusion, icariin possesses a reversal effect on multidrug resistance in MG-63/DOX cells throug... DisGeNET Detail
Costello syndrome (CS) is a rare genetic disorder caused, in the majority of cases, by germline miss... DisGeNET Detail
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When combined with previous studies, our data suggest that dual induction of PAR-2-NFκB inflammatory... DisGeNET Detail
The phosphatidylinositol 3-kinase (PI3K), MAP kinase (MAPK), and related pathways are implicated in ... DisGeNET Detail
R-Ras2 drives tumorigenesis in a phosphatidylinostiol-3 kinase (PI3K)-dependent and signalling auton... DisGeNET Detail
We further show that superactivation of the prosurvival PI3K-AKT signaling pathway limits the effica... DisGeNET Detail
These findings further suggest that regulation of SUMOylation by PI3K/Akt signaling is likely an imp... DisGeNET Detail
The findings indicate that epigenetic inactivation of INPP4B is one of the key mechanisms in activat... DisGeNET Detail
Furthermore, miR-200a induces cell transformation and tumorigenesis in immunocompromised mice by coo... DisGeNET Detail
We here demonstrate that PIK3CA mutations, PTEN loss, PI3K and KRAS activation are early events in e... DisGeNET Detail
Phosphatidylinositol 3-kinases (PI3Ks) play important roles in human tumorigenesis. DisGeNET Detail
Given the contribution of HRG signaling and the PI3K-Akt pathway in particular to tumorigenesis, thi... DisGeNET Detail
The PI3K/Akt and MAP kinase pathways play important roles in a variety of normal cellular processes ... DisGeNET Detail
Single nucleotide polymorphisms (SNPs) in the PI3K/PTEN/AKT/mTOR signaling pathway may contribute to... DisGeNET Detail
Pathways known to affect tumorigenesis across a wide spectrum of tissues are dysregulated, such as t... DisGeNET Detail
The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway appears to be a key regulator in cervical... DisGeNET Detail
Our findings support the de-regulation of the PI3K/Akt/mTOR and MAPK signaling pathways in type I en... DisGeNET Detail
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We identified differential therapeutic vulnerabilities that emerge upon the loss of both PTEN and p5... DisGeNET Detail
A genome-wide RNAi screen identifies FOXO4 as a metastasis-suppressor through counteracting PI3K/AKT... DisGeNET Detail
The impact of miRNA on the canonical TGF-β Smad signalling pathway has been well investigated, hence... DisGeNET Detail
Restoration of PTEN expression or inhibition of PI3K action decreased cPLA₂α expression in PTEN-muta... DisGeNET Detail
Genome-wide analyses have identified four major signaling nodes that are most frequently altered in ... DisGeNET Detail
Targeting the PI3K/Akt pathway in prostate cancer: challenges and opportunities (review). DisGeNET Detail
The findings from this study suggest that the combination of dual PI3K/Akt/mTOR inhibitors (BEZ235 o... DisGeNET Detail
Co-targeting AR and PI3K/AKT signaling has been proposed to be a more effective therapeutic means fo... DisGeNET Detail
The Upregulation of PI3K/Akt and MAP Kinase Pathways is Associated with Resistance of Microtubule-Ta... DisGeNET Detail
Among the cancer networks and STNs we considered, it is found that there is a substantial amount of ... DisGeNET Detail
Inhibiting the PI3K/AKT pathway may be a useful treatment for ovarian carcinoma. DisGeNET Detail
In conclusion, the results of the present study demonstrated that PI3K/AKT and Rab25 significantly c... DisGeNET Detail
These findings revealed that miR‑338‑3p may act as a tumor suppressor that blocks the growth of huma... DisGeNET Detail
Therefore, the hyperactivity of PI3K/Akt pathway and elevated levels of p53R2 can give rise to highl... DisGeNET Detail
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Direct inhibition of PI3K in combination with dual HER2 inhibitors is required for optimal antitumor... DisGeNET Detail
Characterization of breast cancers with PI3K mutations in an academic practice setting using SNaPsho... DisGeNET Detail
Their prognostic value and that of the phosphatidylinositol 3-kinase (PI3K) pathway in BC remains on... DisGeNET Detail
Phosphatidylinositol 3-kinase (PI3K) pathway deregulation (that is PIK3CA mutations and/or phosphata... DisGeNET Detail
Western blot analysis data indicate that MAPK/ERK and PI3K/Akt signaling in breast cancer cells with... DisGeNET Detail
Microarray phosphatome profiling of breast cancer patients unveils a complex phosphatase regulatory ... DisGeNET Detail
In the present study, we have shown for the first time that HBA decreased the expression of phosphot... DisGeNET Detail
Axl as a downstream effector of TGF-β1 via PI3K/Akt-PAK1 signaling pathway promotes tumor invasion a... DisGeNET Detail
Regulation of the cell cycle and PI3K/Akt/mTOR signaling pathway by tanshinone I in human breast can... DisGeNET Detail
LYN(D189Y) overexpression abrogated growth inhibition by fulvestrant and/or the PI3K inhibitor BKM12... DisGeNET Detail
Phosphatidylinositol-3-kinase (PI3K)/AKT pathway mutations are associated with cancer and phosphatid... DisGeNET Detail
The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endo... DisGeNET Detail
In conclusion, activating the PI3K pathway is associated with low pCR to trastuzumab-based treatment... DisGeNET Detail
Estrogen-responsive genes most significantly influenced by cohesin were enriched in pathways associa... DisGeNET Detail
BYL719, which selectively inhibits the alpha isoform of the phosphatidylinositol 3-kinase (PI3K) cat... DisGeNET Detail
We investigated whether mutations in the gene encoding the phosphatidylinositol 3-kinase (PI3K) cata... DisGeNET Detail
In the present study, we demonstrate that PI3K pathway regulates phenotypic changes in breast cancer... DisGeNET Detail
Further, PI3K is thought to be the main driver of lapatinib resistance, but our findings indicate th... DisGeNET Detail
The epidermal growth factor receptor (EGFR)/PI3K/AKT signaling pathway aberrations play significant ... DisGeNET Detail
In the present study, the protein expression levels of SET, protein phosphatase 2A (PP2A) and phosph... DisGeNET Detail
PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-po... DisGeNET Detail
IL-8/PI3K/Akt/NF-κB/integrin β3 axis may be exploited for therapeutic intervention to breast cancer ... DisGeNET Detail
Beyond ER and HER2, BRCA and PIK3CA mutations (when targeted with alpha-specific PI3K inhibitors) co... DisGeNET Detail
Taken together, the prostacyclin/IP/PI3K-p38 MAPK axis has emerged as a novel pro-migratory pathway ... DisGeNET Detail
Resistance to trastuzumab in patients with HER2-overexpressing breast cancer is associated with high... DisGeNET Detail
Collectively, our findings identify PIPP as a suppressor of oncogenic PI3K/AKT signaling in breast c... DisGeNET Detail
Inhibition of Autophagy Increases Proliferation Inhibition and Apoptosis Induced by the PI3K/mTOR In... DisGeNET Detail
RNA interference-mediated knockdown of RhoGDI2 induces the migration and invasion of human lung canc... DisGeNET Detail
Common molecular drivers of lung cancer are mutations in receptor tyrosine kinases (RTKs) leading to... DisGeNET Detail
When the chimeric ubiquitin ligases were introduced into lung cancer SPC-A1 cells, they effectively ... DisGeNET Detail
The altered PI3K/mTOR pathway is implicated in lung cancer, but mTOR inhibitors have failed to demon... DisGeNET Detail
It was found that AKT1 and PI3K/p85 expression was upregulated in LCSCs compared with that in the pr... DisGeNET Detail
Hepatocyte growth factor (HGF) induces resistance to reversible and irreversible epidermal growth fa... DisGeNET Detail
Our data showed that the PTEN/PI3K pathway was active in human ESCC tissues in vivo, particularly in... DisGeNET Detail
Synergism of PI3K/Akt inhibition and Fas activation on colon cancer cell death. DisGeNET Detail
Quinazoline based small molecule exerts potent tumour suppressive properties by inhibiting PI3K/Akt/... DisGeNET Detail
In the present study, the expression status of miR-218 and the role of the phosphoinositide 3-kinase... DisGeNET Detail
Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT... DisGeNET Detail
Here, we detected its effects on DLD-1 and SW480 (two human colon cancer cell lines) and investigate... DisGeNET Detail
These data suggest that EGF-induced activation of MMP7 and MMP13 in GC is through phosphatidylinosit... DisGeNET Detail
In conclusion, knockdown of the c‑Met gene promoted gastric cancer cell apoptosis and inhibited down... DisGeNET Detail
Mechanically, PTP1B promotes gastric cancer cell proliferation, survival and invasiveness through mo... DisGeNET Detail
Therefore, our studies reveal for the first time that inhibition of the PI3K-Akt pathway is involved... DisGeNET Detail
Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-κB signaling pa... DisGeNET Detail
These findings may have high relevance in terms of using PI3K-targeted therapies for BC treatment. DisGeNET Detail
Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential use in the treatment o... DisGeNET Detail
Our findings suggest that miR-21 acts as a molecular switch to regulate aerobic glycolysis in bladde... DisGeNET Detail
Taken together, EN2 may be a candidate oncogene in BC by activating the PI3K/Akt pathway and inhibit... DisGeNET Detail
This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pathway inhibitors in ... DisGeNET Detail
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Moreover, inhibitors of PI3K/mTOR and GLI signaling reduced neuroblastoma cell growth, but no additi... DisGeNET Detail
Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib i... DisGeNET Detail
We previously demonstrated that PI3K Class IIβ (PI3KC2β) and its regulator intersectin 1 (ITSN1) are... DisGeNET Detail
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Targeted inhibition of the PI3K/mTOR and Hhpathways indicates a new avenue for BTC treatment with co... DisGeNET Detail
Divergence of P53, PTEN, PI3K, Akt and mTOR expression in tonsillar cancer. DisGeNET Detail
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MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma. DisGeNET Detail
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Inhibition of PI3K and Akt kinase prevented the phosphorylation of 4E-BP1, suggesting that PI3K sign... DisGeNET Detail
PI3K pathway activation in high-grade ductal carcinoma in situ--implications for progression to inva... DisGeNET Detail
Our model allowed us to test the contributions of oncogenes in the RTK/RAS/PI(3)K pathway, and their... DisGeNET Detail
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In this study we performed multiplex targeted sequencing of 10 genes in the PI3K/AKT pathway on brai... DisGeNET Detail
Re-expression of ARHI in ovarian cancer cells blocks signaling through the PI3K and Ras/MAP pathways... DisGeNET Detail
MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the P... DisGeNET Detail
Moreover, LY294002, a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinases... DisGeNET Detail
The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer. DisGeNET Detail
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A comprehensive evaluation of biomarkers predictive of response to PI3K inhibitors and of resistance... DisGeNET Detail
Additional study is required to develop new model systems and approaches to determine the role of ta... DisGeNET Detail
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Herein, we will review the clinically relevant inhibitors of the PI3K pathway that have been evaluat... DisGeNET Detail
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Our results show that Sendai virus infection, which is recognized by RIG-I, led to IRF3 activation a... DisGeNET Detail
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Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in hum... DisGeNET Detail
Targeted PI3K/AKT/mTOR therapy for metastatic carcinomas of the cervix: A phase I clinical experienc... DisGeNET Detail
We validated the top ranking genes, i.e., PIK3CA and PIK3CB, by showing that their forced expression... DisGeNET Detail
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The tumor suppressor WIF1 was also found to be capable of suppressing tumor growth through the inhib... DisGeNET Detail
Increased CYP4Z2P- and CYP4Z1-3'UTR expression promotes tumor angiogenesis in breast cancer partly v... DisGeNET Detail
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The combination of HER2 inhibitors with PI3K inhibition was studied in HER2-amplified xenograft mode... DisGeNET Detail
Using AR + TNBC cell line and xenograft models we evaluated the effectiveness of PI3K inhibitors, us... DisGeNET Detail
In addition, the phosphoinositide-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway w... DisGeNET Detail
We tested the in vivo efficacy of three PI3K inhibitors (PI3Ki) in patient-derived GIST xenograft mo... DisGeNET Detail
The added predictive value of additional biomarkers in the RAS-RAF-MAPK and PI3K-AKT-mTOR pathways i... DisGeNET Detail
The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer. DisGeNET Detail
These data indicate that the capacity of retinol to inhibit PI3K activity confers its ability to dec... DisGeNET Detail
We conclude that cPLA2α is required for sustaining AKT phosphorylation at Ser473 and cell proliferat... DisGeNET Detail
Inhibitors against KRAS signaling mediators, namely, PI3K (phosphatidylinositol 3-kinase) and mTOR (... DisGeNET Detail
PTEN inactivation by mutation or allelic loss also occurs in CRCs. miR‑135b was reported to be upreg... DisGeNET Detail
The role of the PI3K pathway in colorectal cancer. DisGeNET Detail
Mutations in the RAS and PI3K pathways are associated with metastatic location in colorectal cancers... DisGeNET Detail
Eight of these genes were linked to the Wnt, Hippo, TGF-β, EGF receptor, or PI3K pathways, all invol... DisGeNET Detail
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Preclinical investigations have suggested that the PI3K/AKT/mTOR pathway is frequently activated in ... DisGeNET Detail
Here, using specific inhibitors, we found that the activation of EGFR signaling promoted GBM growth ... DisGeNET Detail
The phosphoinositide 3-kinase (PI3K)/Akt/PTEN signaling pathway is deregulated in GBM. DisGeNET Detail
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Important mechanisms we discuss include (1) improved DNA repair in normal, but not tumor cells; (2) ... DisGeNET Detail
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Although the mutation rates and mutational signatures of MSS and MSI-H EECs were distinct, the preva... DisGeNET Detail
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The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer s... DisGeNET Detail
This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pathway inhibitors in ... DisGeNET Detail
The phosphoinositol-3 kinase (PI3K) pathway is frequently dysregulated in endometrial cancer (EC). DisGeNET Detail
NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt s... DisGeNET Detail
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In this review, we summarize the existing knowledge of the relevance of Notch1 and PI3K/Akt/mTOR sig... DisGeNET Detail
We also explored the molecular mechanism of FHL1C overexpression-induced apoptosis, which suppressed... DisGeNET Detail
High activation of the PI3K-AKT-mTOR pathway is characteristic for T-cell acute lymphoblastic leukem... DisGeNET Detail
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This mode of action for calycopterin in our study provides strong support that inhibition of PI3K/Ak... DisGeNET Detail
The PI3K/Akt/Snail-dependent pathway may mediate the pro-invasive and pro-metastatic effects of sora... DisGeNET Detail
The inhibition of PI3K/Akt activation abolished epithelial-mesenchymal transition (EMT) and invasion... DisGeNET Detail
Bioinformatic method was applied to predict the binding of miR-218 on HoxA10, and western blotting w... DisGeNET Detail
In clinical HCC samples, high expression of both CXCR2 and CXCL5 showed a significant correlation wi... DisGeNET Detail
The purpose of this study was to determine the impact of sorafenib on PI3K/AKT/mTOR signaling pathwa... DisGeNET Detail
HBx induced AFP receptor expressed to activate PI3K/AKT signal to promote expression of Src in liver... DisGeNET Detail
Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepat... DisGeNET Detail
Moreover, LIFR knockdown could activate phosphoinositide 3-kinase/V-akt Murine Thymoma Viral Oncogen... DisGeNET Detail
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Role of selenoprotein S (SEPS1) -105G>A polymorphisms and PI3K/Akt signaling pathway in Kashin-Beck ... DisGeNET Detail
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Epigenetic inactivation of inositol polyphosphate 4-phosphatase B (INPP4B), a regulator of PI3K/AKT ... DisGeNET Detail
The current study demonstrated that EphA2 mediates sensitivity to paclitaxel via the regulation of t... DisGeNET Detail
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Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, are among the most commo... DisGeNET Detail
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The PI3K/AKT/mTOR (PAM) signaling pathway controls key cellular responses, such as cell growth and p... DisGeNET Detail
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Different targeted therapies may be necessary for TNBC that involves activation of PI3K/AKT or MAPK ... DisGeNET Detail
PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to t... DisGeNET Detail
Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show ... DisGeNET Detail
β-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast ca... DisGeNET Detail
Activation of the phosphatidylinositol-3-kinase (PI3K) and/or mitogen-activated protein kinase (MAPK... DisGeNET Detail
Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway has been implicated in anti-... DisGeNET Detail
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Brain overgrowth in disorders of RTK-PI3K-AKT signaling: a mosaic of malformations. DisGeNET Detail
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Following stimulation with 10 nM insulin for 30 min, the stable overexpression of Arg972 IRS-1 and k... DisGeNET Detail
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These findings may have high relevance in terms of using PI3K-targeted therapies for BC treatment. DisGeNET Detail
Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential use in the treatment o... DisGeNET Detail
Our findings suggest that miR-21 acts as a molecular switch to regulate aerobic glycolysis in bladde... DisGeNET Detail
Taken together, EN2 may be a candidate oncogene in BC by activating the PI3K/Akt pathway and inhibit... DisGeNET Detail
NA DisGeNET Detail
Direct inhibition of PI3K in combination with dual HER2 inhibitors is required for optimal antitumor... DisGeNET Detail
Characterization of breast cancers with PI3K mutations in an academic practice setting using SNaPsho... DisGeNET Detail
Their prognostic value and that of the phosphatidylinositol 3-kinase (PI3K) pathway in BC remains on... DisGeNET Detail
Phosphatidylinositol 3-kinase (PI3K) pathway deregulation (that is PIK3CA mutations and/or phosphata... DisGeNET Detail
Western blot analysis data indicate that MAPK/ERK and PI3K/Akt signaling in breast cancer cells with... DisGeNET Detail
Microarray phosphatome profiling of breast cancer patients unveils a complex phosphatase regulatory ... DisGeNET Detail
In the present study, we have shown for the first time that HBA decreased the expression of phosphot... DisGeNET Detail
Axl as a downstream effector of TGF-β1 via PI3K/Akt-PAK1 signaling pathway promotes tumor invasion a... DisGeNET Detail
Regulation of the cell cycle and PI3K/Akt/mTOR signaling pathway by tanshinone I in human breast can... DisGeNET Detail
LYN(D189Y) overexpression abrogated growth inhibition by fulvestrant and/or the PI3K inhibitor BKM12... DisGeNET Detail
Phosphatidylinositol-3-kinase (PI3K)/AKT pathway mutations are associated with cancer and phosphatid... DisGeNET Detail
The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endo... DisGeNET Detail
In conclusion, activating the PI3K pathway is associated with low pCR to trastuzumab-based treatment... DisGeNET Detail
Estrogen-responsive genes most significantly influenced by cohesin were enriched in pathways associa... DisGeNET Detail
BYL719, which selectively inhibits the alpha isoform of the phosphatidylinositol 3-kinase (PI3K) cat... DisGeNET Detail
We investigated whether mutations in the gene encoding the phosphatidylinositol 3-kinase (PI3K) cata... DisGeNET Detail
In the present study, we demonstrate that PI3K pathway regulates phenotypic changes in breast cancer... DisGeNET Detail
Further, PI3K is thought to be the main driver of lapatinib resistance, but our findings indicate th... DisGeNET Detail
The epidermal growth factor receptor (EGFR)/PI3K/AKT signaling pathway aberrations play significant ... DisGeNET Detail
In the present study, the protein expression levels of SET, protein phosphatase 2A (PP2A) and phosph... DisGeNET Detail
PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-po... DisGeNET Detail
IL-8/PI3K/Akt/NF-κB/integrin β3 axis may be exploited for therapeutic intervention to breast cancer ... DisGeNET Detail
Beyond ER and HER2, BRCA and PIK3CA mutations (when targeted with alpha-specific PI3K inhibitors) co... DisGeNET Detail
Taken together, the prostacyclin/IP/PI3K-p38 MAPK axis has emerged as a novel pro-migratory pathway ... DisGeNET Detail
Resistance to trastuzumab in patients with HER2-overexpressing breast cancer is associated with high... DisGeNET Detail
Collectively, our findings identify PIPP as a suppressor of oncogenic PI3K/AKT signaling in breast c... DisGeNET Detail
Inhibition of Autophagy Increases Proliferation Inhibition and Apoptosis Induced by the PI3K/mTOR In... DisGeNET Detail
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Synergism of PI3K/Akt inhibition and Fas activation on colon cancer cell death. DisGeNET Detail
Quinazoline based small molecule exerts potent tumour suppressive properties by inhibiting PI3K/Akt/... DisGeNET Detail
In the present study, the expression status of miR-218 and the role of the phosphoinositide 3-kinase... DisGeNET Detail
Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT... DisGeNET Detail
Here, we detected its effects on DLD-1 and SW480 (two human colon cancer cell lines) and investigate... DisGeNET Detail
The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer s... DisGeNET Detail
This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pathway inhibitors in ... DisGeNET Detail
The phosphoinositol-3 kinase (PI3K) pathway is frequently dysregulated in endometrial cancer (EC). DisGeNET Detail
NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt s... DisGeNET Detail
The phosphatidylinositol 3-kinase (PI3K), MAP kinase (MAPK), and related pathways are implicated in ... DisGeNET Detail
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PI3K pathway activation in high-grade ductal carcinoma in situ--implications for progression to inva... DisGeNET Detail
NA DisGeNET Detail
In conclusion, the positive feedback loop between NOX4 and PI3K/Akt signaling contributes to NSCLC p... DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386584794 dbSNP
Genome
hg38
Position
chr3:138,652,698-138,834,928
Variant Type
snv
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