Annotation Detail
Information
- Associated Genes
- PIK3CB
- Associated Variants
-
PIK3CB MUTATION
PIK3CB MUTATION - Associated Disease
- breast carcinoma
- Source Database
- DisGeNET
- Description
- BYL719, which selectively inhibits the alpha isoform of the phosphatidylinositol 3-kinase (PI3K) catalytic subunit (p110a), is currently in clinical trials for the treatment of solid tumors, especially luminal breast cancers with PIK3CA mutations and/or HER2 amplification.
- Pubmed
- 25544637
- Section of the abstract supporting the evidence
- ALL_TEXT_1/3
- Number of the section of the abstract supporting the evidence
- 1
- Number of the sentence supporting the evidence
- 1
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0431592576607682
Drugs