Annotation Detail
Information
- Associated Genes
- PIK3CB
- Associated Variants
-
PIK3CB MUTATION
PIK3CB MUTATION - Associated Disease
- Mammary Neoplasms
- Source Database
- DisGeNET
- Description
- We validated the top ranking genes, i.e., PIK3CA and PIK3CB, by showing that their forced expression confers resistance to lapatinib in vitro and found that their mutation/overexpression is associated to poor prognosis in human breast tumors.
- Pubmed
- 25195596
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 6
- Original source reporting the Gene Disease association
- BeFree,LHGDN
- DisGENET score for the Gene Disease association
- 0.00598165270743081
Drugs