chr5:131993865:> Detail (hg19)

Information

Genome

Assembly Position
hg19 chr5:131,993,865-131,996,802
hg38 chr5:132,658,173-132,661,110 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.121 renal cell carcinoma NA BeFree,CTD_human Detail
0.003 squamous cell carcinoma NA BeFree,LHGDN Detail
<0.001 Malignant tumor of cervix NA BeFree Detail
0.002 Chlamydia Infections NA GAD Detail
<0.001 Primary biliary cirrhosis NA BeFree Detail
<0.001 colitis NA BeFree Detail
0.005 ulcerative colitis Elevated levels of IL-4 (2.91-fold) and IL-13 (4.05-fold) mRNA were detected in ... BeFree,LHGDN 26072972 Detail
0.001 colorectal carcinoma NA BeFree Detail
0.002 conjunctivitis NA GAD Detail
<0.001 allergic conjunctivitis NA BeFree Detail
0.002 Connective Tissue Diseases NA GAD Detail
0.004 Crohn Disease Elevated levels of IL-4 (2.91-fold) and IL-13 (4.05-fold) mRNA were detected in ... BeFree,LHGDN 26072972 Detail
0.001 dermatitis NA BeFree Detail
0.343 Dermatitis, Atopic Additive effect between IL-13 polymorphism and cesarean section delivery/prenata... BeFree,CTD_human,GAD,GWASCAT,LHGDN,MGD 24848505 Detail
<0.001 scleroderma NA BeFree Detail
<0.001 Diabetes NA BeFree Detail
0.003 diabetes mellitus NA BeFree,LHGDN Detail
0.007 Diabetes Mellitus, Insulin-Dependent NA BeFree,GAD Detail
0.005 Diabetes Mellitus, Non-Insulin-Dependent NA BeFree,GAD Detail
0.001 diphtheria NA BeFree Detail
0.120 drug allergy NA CTD_human Detail
0.011 Eczema Additive effect between IL-13 polymorphism and cesarean section delivery/prenata... BeFree 24848505 Detail
<0.001 encephalitis NA BeFree Detail
<0.001 Experimental Autoimmune Encephalomyelitis NA BeFree Detail
<0.001 endometriosis NA BeFree Detail
0.006 Eosinophilia NA BeFree,GAD Detail
0.003 Toxic Epidermal Necrolysis NA BeFree,GAD Detail
<0.001 Epithelial hyperplasia NA BeFree Detail
0.002 erythema nodosum NA GAD Detail
<0.001 Esophageal Achalasia NA BeFree Detail
0.003 esophagitis NA LHGDN Detail
0.080 peptic esophagitis NA RGD Detail
<0.001 Exophthalmos NA BeFree Detail
<0.001 Disorder of eye NA BeFree Detail
0.002 Fetal Diseases NA GAD Detail
0.091 Fibrosis NA LHGDN,RGD Detail
<0.001 filariasis NA BeFree Detail
<0.001 pathologic fistula NA BeFree Detail
0.002 food allergy NA GAD Detail
0.003 Gastritis, Atrophic NA BeFree,GAD Detail
<0.001 gastroesophageal reflux disease NA BeFree Detail
0.007 Glioma Polymorphisms in IL-4/IL-13 pathway genes and glioma risk: an updated meta-analy... BeFree 25472582 Detail
0.002 IgA glomerulonephritis NA GAD Detail
0.003 Graft-vs-Host Disease NA BeFree,LHGDN Detail
0.011 Graves Disease NA BeFree,GAD Detail
0.008 Hay fever NA BeFree,GAD Detail
<0.001 Head and Neck Neoplasms NA BeFree Detail
<0.001 Helminthiasis NA BeFree Detail
0.080 Hepatitis, Alcoholic NA RGD Detail
0.003 HIV Infections IL-17A expression in HIV-specific CD8 T cells is regulated by IL-4/IL-13 followi... BeFree,GAD 25493691 Detail
0.130 Hodgkin Disease NA BeFree,GAD,GWASCAT,LHGDN Detail
<0.001 Huntington disease NA BeFree Detail
0.123 Hyperplasia NA CTD_human,LHGDN Detail
0.127 Hypersensitivity NA CTD_human,GAD Detail
0.129 Immediate hypersensitivity NA CTD_human,GAD Detail
0.002 Hypertensive disease NA GAD Detail
0.080 pulmonary hypertension The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension. BeFree,RGD 26192556 Detail
<0.001 hyperthyroidism NA BeFree Detail
<0.001 ileitis NA BeFree Detail
<0.001 Immunologic Deficiency Syndromes NA BeFree Detail
<0.001 Immune System Diseases NA BeFree Detail
0.142 Inflammation NA CTD_human,GAD,LHGDN Detail
0.001 Inflammatory Bowel Diseases Recent evidence suggests that both NOX1 and DUOX2 species produce ROS in the gas... BeFree 25818486 Detail
<0.001 influenza NA BeFree Detail
<0.001 Kidney Diseases NA BeFree Detail
<0.001 leishmaniasis This undermined the basic premise that IL-4/IL-13 played paramount roles in faci... BeFree 24412597 Detail
<0.001 Leishmaniasis, Cutaneous The role of IL-4 and IL-13 in cutaneous Leishmaniasis. BeFree 24412597 Detail
<0.001 leprosy NA BeFree Detail
0.002 chronic lymphocytic leukemia NA GAD Detail
<0.001 Leukemia, T-Cell NA BeFree Detail
<0.001 Adult T-Cell Lymphoma/Leukemia NA BeFree Detail
0.121 Lung diseases NA BeFree,CTD_human Detail
0.080 Lung Diseases, Fungal NA RGD Detail
0.029 Chronic Obstructive Airway Disease Lack of association between the G+2044A polymorphism of interleukin-13 gene and ... BeFree,GAD,LHGDN 24990692 Detail
<0.001 Lung Neoplasms NA BeFree Detail
0.003 Lupus Erythematosus, Systemic NA BeFree,GAD Detail
0.002 lymphoma NA BeFree Detail
<0.001 Lymphoma, Non-Hodgkin NA BeFree Detail
<0.001 Lymphoproliferative Disorders NA BeFree Detail
0.001 malaria NA BeFree Detail
<0.001 Malaria, Cerebral NA BeFree Detail
0.005 Malaria, Falciparum NA BeFree,GAD Detail
<0.001 Malignant neoplasm of stomach NA BeFree Detail
<0.001 Mastocytoma NA BeFree Detail
<0.001 mastocytosis NA BeFree Detail
<0.001 Mastodynia NA BeFree Detail
<0.001 measles NA BeFree Detail
<0.001 medulloblastoma NA BeFree Detail
<0.001 melanoma NA BeFree Detail
<0.001 meningioma NA BeFree Detail
0.120 Metaplasia NA CTD_human Detail
0.003 multiple myeloma NA BeFree,GAD Detail
0.003 Multiple Organ Failure NA LHGDN Detail
0.002 Musculoskeletal Diseases NA GAD Detail
<0.001 Mycoses NA BeFree Detail
<0.001 mycosis fungoides NA BeFree Detail
<0.001 myocarditis We found the induction of myocarditis was associated with the upregulation of Co... BeFree 24533969 Detail
<0.001 Nasal congestion (finding) NA BeFree Detail
0.002 Nasal Polyps Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps... BeFree 25674935 Detail
<0.001 Neck Neoplasms NA BeFree Detail
<0.001 Nematode infections NA BeFree Detail
<0.001 Neoplasm Metastasis Upon stimulation with IL-13, IL-13Rα2 increased the extracellular signal-regulat... BeFree 24747967 Detail
0.080 lipoid nephrosis NA BeFree,RGD Detail
0.008 nephrotic syndrome NA BeFree,GAD Detail
<0.001 oligodendroglioma NA BeFree Detail
0.005 onchocerciasis NA BeFree,GAD,LHGDN Detail
<0.001 orbit (eye disorders) NA BeFree Detail
0.003 Degenerative polyarthritis NA BeFree,GAD Detail
<0.001 ovarian carcinoma NA BeFree Detail
<0.001 Pancreatic Neoplasm NA BeFree Detail
0.080 pancreatitis NA RGD Detail
<0.001 bullous pemphigoid To investigate the contribution of M2 macrophages to the pathogenesis of bullous... BeFree 25401296 Detail
<0.001 pemphigus vulgaris To investigate the contribution of M2 macrophages to the pathogenesis of bullous... BeFree 25401296 Detail
0.002 Peptic Ulcer NA GAD Detail
<0.001 periodontitis NA BeFree Detail
0.003 Periodontitis, Juvenile NA BeFree,GAD Detail
0.125 pneumonia NA BeFree,CTD_human,LHGDN Detail
<0.001 polyps An increased level of POSTN, IL-4, and IL-13 gene expression may be related to t... BeFree 25674935 Detail
0.002 pre-eclampsia NA GAD Detail
0.002 Pregnancy Complications NA GAD Detail
0.002 Pregnancy Complications, Hematologic NA GAD Detail
0.002 Prenatal Exposure Delayed Effects NA GAD Detail
<0.001 Prostatic Neoplasms NA BeFree Detail
<0.001 Pruritus NA BeFree Detail
0.251 psoriasis NA BeFree,CTD_human,GAD,GWASCAT,LHGDN Detail
0.002 Puerperal Disorders NA GAD Detail
<0.001 pulmonary emphysema NA BeFree Detail
<0.001 pulmonary eosinophilia NA BeFree Detail
0.201 pulmonary fibrosis Understanding the function of CXCR3 in IL-13-mediated lung injury may lead to no... BeFree,CTD_human,RGD 25514189 Detail
0.002 purpura NA GAD Detail
0.080 Reperfusion Injury NA RGD Detail
<0.001 Respiration Disorders NA BeFree Detail
<0.001 Respiratory Distress Syndrome, Adult High-producing alleles of anti-inflammatory cytokines IL4 -589T and IL13 431A (1... BeFree 25619315 Detail
0.007 Respiratory Syncytial Virus Infections Consistent with the data from RSV-infected infants, CD4 T cell production of Int... BeFree,GAD 24838148 Detail
<0.001 Respiratory Tract Diseases NA BeFree Detail
<0.001 Respiratory Tract Infections NA BeFree Detail
0.091 rhinitis The single nucleotide polymorphism specifically associated to asthma plus rhinit... BeFree,GAD,LHGDN,RGD 24560411 Detail
0.002 sarcoidosis NA GAD Detail
<0.001 Kaposi sarcoma Constitutive Activation of Interleukin-13/STAT6 Contributes to Kaposi's Sarcoma-... BeFree 26246572 Detail
<0.001 schistosomiasis Combined IL-4 and IL-13 deficiency is required for protection against TGF-β-indu... BeFree 26192556 Detail
0.002 Schistosomiasis japonica NA GAD Detail
0.088 Schistosomiasis mansoni NA BeFree,GAD,LHGDN,RGD Detail
0.010 systemic scleroderma In contrast, Treg cells from skin affected by SSc produced significant amounts o... BeFree,GAD,LHGDN 25678090 Detail
0.010 systemic scleroderma These findings indicate that upregulated CD226 expression on CD8(+) T cells refl... BeFree,GAD,LHGDN 26109642 Detail
<0.001 Sezary syndrome NA BeFree Detail
0.120 sinusitis NA CTD_human Detail
0.003 Dermatologic disorders NA BeFree,GAD Detail
<0.001 ankylosing spondylitis NA BeFree Detail
0.003 Stevens-Johnson syndrome NA BeFree,GAD Detail
0.002 Streptococcal Infections NA GAD Detail
<0.001 tetanus NA BeFree Detail
<0.001 Thyroid Diseases NA BeFree Detail
<0.001 Thyroid Nodule NA BeFree Detail
<0.001 Tongue Neoplasms NA BeFree Detail
<0.001 Ocular Toxoplasmosis NA BeFree Detail
0.002 trachoma NA GAD Detail
0.002 tuberculosis NA GAD Detail
<0.001 ureteral obstruction NA BeFree Detail
0.003 urticaria NA LHGDN Detail
<0.001 urticaria pigmentosa NA BeFree Detail
<0.001 Vascular Diseases Combined IL-4 and IL-13 deficiency is required for protection against TGF-β-indu... BeFree 26192556 Detail
<0.001 Virus Diseases NA BeFree Detail
<0.001 intestinal volvulus Isolated PBMCs from O. volvulus-infected individuals (164 MF(+) and 46 a-MF) and... BeFree 25889652 Detail
0.002 Wheezing NA BeFree Detail
0.002 Helicobacter Infections NA GAD Detail
<0.001 B-Cell Lymphomas NA BeFree Detail
0.003 diffuse large B-cell lymphoma NA BeFree,GAD Detail
<0.001 Lymphoma, Large-Cell, Follicular NA BeFree Detail
<0.001 Lymphoma, T-Cell, Cutaneous NA BeFree Detail
<0.001 spina bifida NA BeFree Detail
0.002 Lymphoma, AIDS-Related NA GAD Detail
<0.001 severe combined immunodeficiency NA BeFree Detail
0.129 Bronchial Hyperreactivity NA BeFree,CTD_human,GAD,LHGDN Detail
0.002 Central Nervous System Neoplasms NA GAD Detail
0.002 bacterial vaginosis NA GAD Detail
0.002 Wheezing There was a statistically significant association between the IL-13 Arg144Gln po... BeFree 19674346 Detail
<0.001 Hamman-Rich syndrome NA BeFree Detail
<0.001 Idiopathic Membranous Glomerulonephritis NA BeFree Detail
<0.001 Chronic sinusitis Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps... BeFree 25674935 Detail
<0.001 Pancreatitis, Chronic Recent evidence suggests that both NOX1 and DUOX2 species produce ROS in the gas... BeFree 25818486 Detail
<0.001 Epstein-Barr Virus Infections NA BeFree Detail
0.012 Premature Birth NA GAD,LHGDN Detail
<0.001 renal fibrosis NA BeFree Detail
<0.001 Idiopathic pulmonary hypertension NA BeFree Detail
<0.001 Hodgkin's disease, nodular sclerosis (clinical) NA BeFree Detail
<0.001 Malignant neoplasm of testis NA BeFree Detail
0.003 Malignant neoplasm of brain NA BeFree,GAD Detail
<0.001 proliferative diabetic retinopathy Increased expression of M-CSF and IL-13 in vitreous of patients with proliferati... BeFree 25355804 Detail
<0.001 Corneal pannus NA BeFree Detail
0.012 allergic asthma These results demonstrate an anti-lymphangiogenic function of TH2 cells and thei... BeFree,GAD 25648335 Detail
<0.001 intrinsic asthma NA BeFree Detail
<0.001 Peritoneal adhesion NA BeFree Detail
<0.001 Right Ventricular Hypertrophy IL-4(-/-)IL-13(-/-) mice, but not single knockout IL-4(-/-) or IL-13(-/-) mice, ... BeFree 26192556 Detail
<0.001 Autoimmune thyroid disease NA BeFree Detail
<0.001 Tumor Progression NA BeFree Detail
<0.001 Pneumonia, Interstitial NA BeFree Detail
<0.001 cholangiocarcinoma NA BeFree Detail
<0.001 gliosarcoma NA BeFree Detail
0.003 Mastocytosis, Systemic NA BeFree,GAD Detail
0.001 pancreatic carcinoma Recent evidence suggests that both NOX1 and DUOX2 species produce ROS in the gas... BeFree 25818486 Detail
0.002 Small for gestational age (disorder) NA GAD Detail
<0.001 desquamative interstitial pneumonia NA BeFree Detail
<0.001 Hand eczema NA BeFree Detail
0.120 Hepatitis, Autoimmune NA CTD_human Detail
0.080 Acute Lung Injury NA RGD Detail
0.002 intestinal schistosomiasis NA GAD Detail
0.002 Parasitemia NA GAD Detail
0.082 Sepsis NA GAD,RGD Detail
<0.001 Psoriasis vulgaris NA BeFree Detail
0.004 Childhood asthma NA BeFree,GAD Detail
<0.001 Asthma, Occupational NA BeFree Detail
0.003 Chronic Periodontitis NA BeFree,GAD Detail
0.002 idiopathic generalized epilepsy NA GAD Detail
0.005 Schistosoma hematobium infection NA BeFree,GAD,LHGDN Detail
0.001 Cancer of Head and Neck NA BeFree Detail
<0.001 Solid tumour NA BeFree Detail
<0.001 Parainfluenza Virus Infections NA BeFree Detail
<0.001 cervix carcinoma NA BeFree Detail
<0.001 Senile Plaques NA BeFree Detail
<0.001 Pheochromocytoma, malignant NA BeFree Detail
<0.001 mast cell neoplasm NA BeFree Detail
<0.001 Thyroid associated opthalmopathies NA BeFree Detail
<0.001 Seasonal allergic conjunctivitis NA BeFree Detail
<0.001 Aspirin-sensitive asthma with nasal polyps NA BeFree Detail
<0.001 Asthmatic pulmonary eosinophilia NA BeFree Detail
0.003 eosinophilic esophagitis Together, these data comprise new potential biomarkers of EoE and demonstrate a ... BeFree 24920534 Detail
0.003 eosinophilic esophagitis Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis. BeFree 25226850 Detail
<0.001 multinodular goiter NA BeFree Detail
<0.001 Sowda NA BeFree Detail
0.001 Malignant neoplasm of pancreas NA BeFree Detail
0.002 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site Consistent with the data from RSV-infected infants, CD4 T cell production of Int... BeFree 24838148 Detail
<0.001 Malignant neoplasm of prostate NA BeFree Detail
0.021 Atopy NA GAD Detail
<0.001 Steroid-sensitive nephrotic syndrome NA BeFree Detail
<0.001 Actinic prurigo NA BeFree Detail
<0.001 Respiratory distress NA BeFree Detail
0.002 Dermatitis and eczema NA GAD Detail
<0.001 Secondary malignant neoplasm of liver NA BeFree Detail
<0.001 Mixed cryoglobulinemia NA BeFree Detail
<0.001 Deviated nasal septum The objective of this study was to determine differential expression of POSTN, I... BeFree 25674935 Detail
<0.001 Thyroid carcinoma NA BeFree Detail
<0.001 BREAST PAIN FEMALE NA BeFree Detail
0.003 Malignant glioma NA BeFree Detail
0.130 Hodgkin Disease No associations were observed between the other IL-10 gene variations, IL-13(-10... BeFree 23299779 Detail
0.002 Allergy to eggs NA GAD Detail
<0.001 primary sclerosing cholangitis NA BeFree Detail
0.005 latex allergy NA GAD Detail
<0.001 Aqueous Humor Disorders NA BeFree Detail
0.004 Childhood asthma The 6 loci (IL-13 C-1112T, IL-13 C1923T, IL-4 C-590T, IL-4RA 175V, FcER1B E237G ... BeFree 19862939 Detail
<0.001 Carcinogenesis NA BeFree Detail
<0.001 Leukemogenesis NA BeFree Detail
<0.001 prostate carcinoma NA BeFree Detail
0.001 breast carcinoma Upon stimulation with IL-13, IL-13Rα2 increased the extracellular signal-regulat... BeFree 24747967 Detail
<0.001 bacterial sepsis NA BeFree Detail
<0.001 stomach carcinoma NA BeFree Detail
0.002 airway disease NA BeFree Detail
0.080 Infarction, Middle Cerebral Artery NA RGD Detail
<0.001 allergic symptom NA BeFree Detail
<0.001 Well Differentiated Oligodendroglioma NA BeFree Detail
<0.001 Helicobacter pylori infection NA BeFree Detail
<0.001 Asthma chronic NA BeFree Detail
<0.001 ovarian neoplasm NA BeFree Detail
<0.001 Polyp of large intestine NA BeFree Detail
<0.001 Arthritis, Collagen-Induced NA BeFree Detail
0.200 Arthritis, Experimental NA CTD_human,RGD Detail
<0.001 cutaneous mastocytosis NA BeFree Detail
<0.001 Malignant neoplasm of ovary NA BeFree Detail
<0.001 Squamous cell carcinoma of the head and neck NA BeFree Detail
<0.001 diffuse scleroderma NA BeFree Detail
<0.001 Persistent infection NA BeFree Detail
<0.001 X-Linked Combined Immunodeficiency Diseases NA BeFree Detail
<0.001 nonspecific interstitial pneumonia NA BeFree Detail
0.002 Inflammatory disorder Allergic rhinitis (AR) is a polygenic inflammatory disorder of the nasal mucosa ... BeFree 24974143 Detail
0.002 Inflammatory disorder Allergic rhinitis (AR) is an inflammatory disorder of the upper airway. BeFree 25075448 Detail
0.001 Chronic inflammatory disorder NA BeFree Detail
<0.001 Primary Effusion Lymphoma Importantly, we also found that depletion of IL-13 reduces PEL cell growth and s... BeFree 26246572 Detail
<0.001 Mediastinal (Thymic) Large B-Cell Lymphoma NA BeFree Detail
<0.001 Adenoma of large intestine NA BeFree Detail
0.003 Eosinophilic disorder NA BeFree Detail
<0.001 Classical Hodgkin's Lymphoma NA BeFree Detail
<0.001 pancreatic ductal adenocarcinoma NA BeFree Detail
<0.001 renal carcinoma NA BeFree Detail
<0.001 Neonatal necrotizing enterocolitis NA BeFree Detail
<0.001 Tumor Immunity NA BeFree Detail
<0.001 Xenograft Model NA BeFree Detail
0.001 colorectal cancer NA BeFree Detail
0.002 Sjogren's syndrome NA GAD Detail
<0.001 Rash and Dermatitis Adverse Event Associated with Chemoradiation NA BeFree Detail
<0.001 Non-Malignant Ascites Adverse Event NA BeFree Detail
0.002 Glioblastoma multiforme NA BeFree Detail
0.003 Disorder characterized by eosinophilia NA BeFree Detail
<0.001 Associated Pulmonary Arterial Hypertension Combined IL-4 and IL-13 deficiency is required for protection against TGF-β-indu... BeFree 26192556 Detail
<0.001 Glomerulonephritis, Minimal Change NA BeFree Detail
<0.001 Nephrotic Syndrome, Minimal Change NA BeFree Detail
<0.001 Aggressive periodontitis, generalized NA BeFree Detail
0.004 Idiopathic Pulmonary Fibrosis IL-13, a profibrotic cytokine that plays a role in IPF, functions through the Ja... BeFree,LHGDN 25514189 Detail
<0.001 EPIDERMAL DIFFERENTIATION COMPLEX NA BeFree Detail
<0.001 FRAGILE X TREMOR/ATAXIA SYNDROME NA BeFree Detail
0.005 Venous thromboembolism NA GAD Detail
<0.001 Syndactyly, Type IV NA BeFree Detail
0.002 coronary artery disease NA GAD Detail
<0.001 liver carcinoma Association between polymorphism of the interleukin-13 gene and susceptibility t... BeFree 25658755 Detail
<0.001 benign mastocytoma NA BeFree Detail
0.001 Idiopathic Interstitial Pneumonias NA BeFree Detail
0.133 Allergic rhinitis (disorder) Allergic rhinitis (AR) is a polygenic inflammatory disorder of the nasal mucosa ... BeFree,CTD_human,GAD 24974143 Detail
0.133 Allergic rhinitis (disorder) Allergic rhinitis (AR) is induced by the allergen exposure leading to consequent... BeFree,CTD_human,GAD 25070832 Detail
0.133 Allergic rhinitis (disorder) Allergic rhinitis (AR) is an inflammatory disorder of the upper airway. BeFree,CTD_human,GAD 25075448 Detail
0.133 Allergic rhinitis (disorder) Allergic rhinitis (AR) is a common chronic inflammatory condition of the nasal m... BeFree,CTD_human,GAD 25529447 Detail
0.133 Allergic rhinitis (disorder) Allergic rhinitis (AR) is an inflammatory condition of the nasal cavity caused b... BeFree,CTD_human,GAD 25675851 Detail
0.133 Allergic rhinitis (disorder) To define clusters in allergic rhinitis and to compare them with ARIA (Allergic ... BeFree,CTD_human,GAD 25924687 Detail
0.080 Prostatic Hyperplasia NA RGD Detail
<0.001 Pulmonary arterial hypertension NA BeFree Detail
<0.001 Bisphosphonate-associated osteonecrosis NA BeFree Detail
<0.001 Nonalcoholic Steatohepatitis NA BeFree Detail
0.003 Juvenile arthritis NA BeFree,GAD Detail
0.007 Allergic disposition Allergic rhinitis and allergy are complex conditions, in which both genetic and ... BeFree 25304232 Detail
0.002 Allergic sensitization NA BeFree Detail
<0.001 Neutrophilia (disorder) We found that both clarithromycin and dexamethasone up-regulated the production ... BeFree 26047816 Detail
0.013 Infection NA GAD,LHGDN Detail
<0.001 juvenile rheumatoid arthritis NA BeFree Detail
<0.001 Pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia NA BeFree Detail
0.003 adenocarcinoma NA LHGDN Detail
<0.001 alopecia areata NA BeFree Detail
0.080 extrinsic allergic alveolitis NA RGD Detail
<0.001 Alzheimer's disease NA BeFree Detail
<0.001 amebiasis NA BeFree Detail
0.003 amyotrophic lateral sclerosis NA LHGDN Detail
<0.001 anthracosis NA BeFree Detail
<0.001 arthritis NA BeFree Detail
<0.001 Arthritis, Adjuvant-Induced NA BeFree Detail
0.004 Arthritis, Psoriatic NA BeFree,GAD Detail
0.002 rheumatoid arthritis NA BeFree Detail
0.491 asthma The single nucleotide polymorphism specifically associated to asthma plus rhinit... BeFree,CTD_human,GAD,GWASCAT,LHGDN,RGD 24560411 Detail
0.491 asthma The IL13 C1923T locus predisposed to asthma in Mauritian Indian children, which ... BeFree,CTD_human,GAD,GWASCAT,LHGDN,RGD 24838642 Detail
0.491 asthma IL13, CD14 and ADRB2, which are located in this risk locus, are among the genes ... BeFree,CTD_human,GAD,GWASCAT,LHGDN,RGD 25233048 Detail
0.491 asthma IL-27, in combination with a type 2/CCL26 signature, identifies a more SA phenot... BeFree,CTD_human,GAD,GWASCAT,LHGDN,RGD 25312760 Detail
0.491 asthma The importance of RGS2 down-regulation was then determined in an acute IL-13 mou... BeFree,CTD_human,GAD,GWASCAT,LHGDN,RGD 25368964 Detail
0.491 asthma A meta-analysis of IL-13 polymorphisms and pediatric asthma risk. BeFree,CTD_human,GAD,GWASCAT,LHGDN,RGD 25502839 Detail
0.491 asthma Furthermore, the in vivo blockade of IL-4 and/or IL-13 in an asthma model not on... BeFree,CTD_human,GAD,GWASCAT,LHGDN,RGD 25648335 Detail
0.491 asthma Type 2 innate lymphoid cells (ILC2s) are a newly identified subset of immune cel... BeFree,CTD_human,GAD,GWASCAT,LHGDN,RGD 25769613 Detail
0.002 Asthma, Exercise-Induced NA GAD Detail
0.003 atherosclerosis NA BeFree,GAD Detail
0.120 autistic disorder NA CTD_human Detail
<0.001 Autoimmune Diseases NA BeFree Detail
0.002 Biliary Tract Neoplasm NA GAD Detail
0.003 Malignant neoplasm of urinary bladder NA BeFree,GAD Detail
<0.001 bladder exstrophy NA BeFree Detail
0.005 Brain Neoplasms NA BeFree,GAD Detail
0.004 Malignant neoplasm of breast Upon stimulation with IL-13, IL-13Rα2 increased the extracellular signal-regulat... BeFree,GAD 24747967 Detail
<0.001 bronchiolitis NA BeFree Detail
<0.001 bronchiolitis obliterans NA BeFree Detail
0.005 Bronchiolitis, Viral NA GAD Detail
<0.001 Cachexia NA BeFree Detail
<0.001 Rectal Carcinoma NA BeFree Detail
<0.001 Malignant neoplasm of thyroid NA BeFree Detail
Annotation

Annotations

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Elevated levels of IL-4 (2.91-fold) and IL-13 (4.05-fold) mRNA were detected in the inflamed colon m... DisGeNET Detail
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Elevated levels of IL-4 (2.91-fold) and IL-13 (4.05-fold) mRNA were detected in the inflamed colon m... DisGeNET Detail
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Additive effect between IL-13 polymorphism and cesarean section delivery/prenatal antibiotics use on... DisGeNET Detail
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Additive effect between IL-13 polymorphism and cesarean section delivery/prenatal antibiotics use on... DisGeNET Detail
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Polymorphisms in IL-4/IL-13 pathway genes and glioma risk: an updated meta-analysis. DisGeNET Detail
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IL-17A expression in HIV-specific CD8 T cells is regulated by IL-4/IL-13 following HIV-1 prime-boost... DisGeNET Detail
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The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension. DisGeNET Detail
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Recent evidence suggests that both NOX1 and DUOX2 species produce ROS in the gastrointestinal tract ... DisGeNET Detail
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This undermined the basic premise that IL-4/IL-13 played paramount roles in facilitating a non-heali... DisGeNET Detail
The role of IL-4 and IL-13 in cutaneous Leishmaniasis. DisGeNET Detail
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Lack of association between the G+2044A polymorphism of interleukin-13 gene and chronic obstructive ... DisGeNET Detail
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We found the induction of myocarditis was associated with the upregulation of Col I, α-SMA, Gal-3, I... DisGeNET Detail
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Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps. DisGeNET Detail
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Upon stimulation with IL-13, IL-13Rα2 increased the extracellular signal-regulated kinases 1 and 2 p... DisGeNET Detail
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To investigate the contribution of M2 macrophages to the pathogenesis of bullous pemphigoid (BP) and... DisGeNET Detail
To investigate the contribution of M2 macrophages to the pathogenesis of bullous pemphigoid (BP) and... DisGeNET Detail
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An increased level of POSTN, IL-4, and IL-13 gene expression may be related to the development of ch... DisGeNET Detail
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Understanding the function of CXCR3 in IL-13-mediated lung injury may lead to novel approaches to co... DisGeNET Detail
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High-producing alleles of anti-inflammatory cytokines IL4 -589T and IL13 431A (144Gln) were less fre... DisGeNET Detail
Consistent with the data from RSV-infected infants, CD4 T cell production of Interleukin (IL)-9, IL-... DisGeNET Detail
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The single nucleotide polymorphism specifically associated to asthma plus rhinitis is located in the... DisGeNET Detail
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Constitutive Activation of Interleukin-13/STAT6 Contributes to Kaposi's Sarcoma-Associated Herpesvir... DisGeNET Detail
Combined IL-4 and IL-13 deficiency is required for protection against TGF-β-induced pulmonary vascul... DisGeNET Detail
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In contrast, Treg cells from skin affected by SSc produced significant amounts of IL-4 and IL-13. DisGeNET Detail
These findings indicate that upregulated CD226 expression on CD8(+) T cells reflects disease severit... DisGeNET Detail
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Combined IL-4 and IL-13 deficiency is required for protection against TGF-β-induced pulmonary vascul... DisGeNET Detail
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Isolated PBMCs from O. volvulus-infected individuals (164 MF(+) and 46 a-MF) and non-infected volunt... DisGeNET Detail
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There was a statistically significant association between the IL-13 Arg144Gln polymorphism and risk ... DisGeNET Detail
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Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps. DisGeNET Detail
Recent evidence suggests that both NOX1 and DUOX2 species produce ROS in the gastrointestinal tract ... DisGeNET Detail
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Increased expression of M-CSF and IL-13 in vitreous of patients with proliferative diabetic retinopa... DisGeNET Detail
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These results demonstrate an anti-lymphangiogenic function of TH2 cells and their cytokines, suggest... DisGeNET Detail
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IL-4(-/-)IL-13(-/-) mice, but not single knockout IL-4(-/-) or IL-13(-/-) mice, were protected from ... DisGeNET Detail
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Recent evidence suggests that both NOX1 and DUOX2 species produce ROS in the gastrointestinal tract ... DisGeNET Detail
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Together, these data comprise new potential biomarkers of EoE and demonstrate a novel role for lncRN... DisGeNET Detail
Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis. DisGeNET Detail
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Consistent with the data from RSV-infected infants, CD4 T cell production of Interleukin (IL)-9, IL-... DisGeNET Detail
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The objective of this study was to determine differential expression of POSTN, IL-4, and IL-13 genes... DisGeNET Detail
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No associations were observed between the other IL-10 gene variations, IL-13(-1069CT), IL-13(Q144R),... DisGeNET Detail
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The 6 loci (IL-13 C-1112T, IL-13 C1923T, IL-4 C-590T, IL-4RA 175V, FcER1B E237G and 12-ADR Q27E) mak... DisGeNET Detail
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Upon stimulation with IL-13, IL-13Rα2 increased the extracellular signal-regulated kinases 1 and 2 p... DisGeNET Detail
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Allergic rhinitis (AR) is a polygenic inflammatory disorder of the nasal mucosa with an increasing p... DisGeNET Detail
Allergic rhinitis (AR) is an inflammatory disorder of the upper airway. DisGeNET Detail
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Importantly, we also found that depletion of IL-13 reduces PEL cell growth and survival. DisGeNET Detail
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Combined IL-4 and IL-13 deficiency is required for protection against TGF-β-induced pulmonary vascul... DisGeNET Detail
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IL-13, a profibrotic cytokine that plays a role in IPF, functions through the Jak/STAT pathway after... DisGeNET Detail
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Association between polymorphism of the interleukin-13 gene and susceptibility to hepatocellular car... DisGeNET Detail
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Allergic rhinitis (AR) is a polygenic inflammatory disorder of the nasal mucosa with an increasing p... DisGeNET Detail
Allergic rhinitis (AR) is induced by the allergen exposure leading to consequential structural abnor... DisGeNET Detail
Allergic rhinitis (AR) is an inflammatory disorder of the upper airway. DisGeNET Detail
Allergic rhinitis (AR) is a common chronic inflammatory condition of the nasal mucosal tissue. DisGeNET Detail
Allergic rhinitis (AR) is an inflammatory condition of the nasal cavity caused by environmental alle... DisGeNET Detail
To define clusters in allergic rhinitis and to compare them with ARIA (Allergic Rhinitis and Its Imp... DisGeNET Detail
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Allergic rhinitis and allergy are complex conditions, in which both genetic and environmental factor... DisGeNET Detail
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We found that both clarithromycin and dexamethasone up-regulated the production of anti-inflammatory... DisGeNET Detail
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The single nucleotide polymorphism specifically associated to asthma plus rhinitis is located in the... DisGeNET Detail
The IL13 C1923T locus predisposed to asthma in Mauritian Indian children, which represents an ethnic... DisGeNET Detail
IL13, CD14 and ADRB2, which are located in this risk locus, are among the genes most strongly associ... DisGeNET Detail
IL-27, in combination with a type 2/CCL26 signature, identifies a more SA phenotype, perhaps through... DisGeNET Detail
The importance of RGS2 down-regulation was then determined in an acute IL-13 mouse model of asthma. DisGeNET Detail
A meta-analysis of IL-13 polymorphisms and pediatric asthma risk. DisGeNET Detail
Furthermore, the in vivo blockade of IL-4 and/or IL-13 in an asthma model not only increases the den... DisGeNET Detail
Type 2 innate lymphoid cells (ILC2s) are a newly identified subset of immune cells that, along with ... DisGeNET Detail
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Upon stimulation with IL-13, IL-13Rα2 increased the extracellular signal-regulated kinases 1 and 2 p... DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386555165 dbSNP
Genome
hg19
Position
chr5:131,993,865-131,996,802
Variant Type
snv
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