Annotation Detail
Information
- Associated Genes
- IL13
- Associated Variants
-
IL13 MUTATION
IL13 MUTATION - Associated Disease
- systemic scleroderma
- Source Database
- DisGeNET
- Description
- These findings indicate that upregulated CD226 expression on CD8(+) T cells reflects disease severity and is involved in SSc pathogenesis via the production of various cytokines, including profibrotic IL-13 and endothelial cell injury, and that CD226 may be a useful target in the treatment of SSc.
- Pubmed
- 26109642
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 7
- Original source reporting the Gene Disease association
- BeFree,GAD,LHGDN
- DisGENET score for the Gene Disease association
- 0.0102587093122591
Drugs