chr3:179148357:> Detail (hg38) (PIK3CA)

Information

Genome

Assembly Position
hg19 chr3:178,866,145-178,957,881 
hg38 chr3:179,148,357-179,240,093

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
Disease Drug EL ET ED CS VO TR Pubmed Links
breast cancer B Prognostic Supports Better Outcome Somatic 4 17947469 Detail
breast cancer B Prognostic Supports Poor Outcome Somatic 4 17947469 Detail
DisGeNET
Score Disease name Description Source Pubmed Links
0.128 renal cell carcinoma Taken together, our findings indicate that ghrelin can activate Snail function v... BeFree,CTD_human,LHGDN 25925728 Detail
0.149 squamous cell carcinoma Importantly, the level of miR-508 correlates with poor survival and activated PI... BeFree,CTD_human,GAD,LHGDN 25099196 Detail
0.149 squamous cell carcinoma Patients with adenocarcinoma had fewer PIK3CA mutations (14%), and survived long... BeFree,CTD_human,GAD,LHGDN 25426553 Detail
0.149 squamous cell carcinoma PIK3CA-mutated NSCLC represents a clinically and genetically heterogeneous subgr... BeFree,CTD_human,GAD,LHGDN 25473901 Detail
0.149 squamous cell carcinoma Phosphoinositide-3-kinase (PI3K)-α inhibitors have shown clinical activity in sq... BeFree,CTD_human,GAD,LHGDN 25873175 Detail
0.149 squamous cell carcinoma Moreover, blocking the whole PI3K-AKT-mTOR pathway with the PI3K/mTOR dual inhib... BeFree,CTD_human,GAD,LHGDN 26216950 Detail
0.001 Carcinoma, Transitional Cell NA BeFree Detail
<0.001 carcinosarcoma NA BeFree Detail
<0.001 Cardiomyopathy, Dilated NA BeFree Detail
<0.001 cerebral infarction NA BeFree Detail
0.004 Malignant tumor of cervix Taken together, our data suggest that anti-VEGFa treatment in cervical cancer ma... BeFree 25135429 Detail
0.004 Malignant tumor of cervix CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical ... BeFree 25310288 Detail
0.004 Malignant tumor of cervix Peroxisome proliferator-activated receptor-gamma agonist 4-O-methylhonokiol indu... BeFree 25563418 Detail
0.004 Malignant tumor of cervix The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein is pr... BeFree 25738254 Detail
0.004 Malignant tumor of cervix Butein suppresses cervical cancer growth through the PI3K/AKT/mTOR pathway. BeFree 25962638 Detail
0.002 Uterine Cervical Neoplasm NA GAD Detail
<0.001 Chikungunya Fever In cells infected with the closely related chikungunya virus (CHIKV), the PI3K-A... BeFree 26339054 Detail
0.001 chondrosarcoma Stimulation of chondrosarcoma with CCL5 augmented PI3K and Akt phosphorylation, ... BeFree 25301739 Detail
<0.001 chordoma NA BeFree Detail
<0.001 choriocarcinoma NA BeFree Detail
0.001 Congenital chromosomal disease In acute myeloid leukemia (AML), several signaling pathways such as the phosphat... BeFree 25322685 Detail
<0.001 colitis NA BeFree Detail
0.014 Colonic Neoplasms NA BeFree,GAD,LHGDN Detail
0.002 Colonic Polyps NA GAD Detail
0.139 Colorectal Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
0.002 Common Bile Duct Neoplasms NA GAD Detail
<0.001 Coronary Arteriosclerosis bFGF regulates autophagy and ubiquitinated protein accumulation induced by myoca... BeFree 25787015 Detail
0.120 adenoid cystic carcinoma NA CTD_human Detail
<0.001 cystadenoma NA BeFree Detail
<0.001 Phyllodes Tumor NA BeFree Detail
0.003 Cessation of life NA LHGDN Detail
<0.001 scleroderma NA BeFree Detail
<0.001 dermatosis papulosa nigra NA BeFree Detail
0.001 Diabetes NA BeFree Detail
0.002 diabetes mellitus NA BeFree Detail
0.004 Diabetes Mellitus, Non-Insulin-Dependent Effects of D-Pinitol on Insulin Resistance through the PI3K/Akt Signaling Pathwa... BeFree,GAD 26063468 Detail
<0.001 Diabetic Nephropathy Podocyte-specific genetic ablation of XBP1 or inducible expression of ATF6 in mi... BeFree 25754093 Detail
0.020 Endometrial Neoplasms NA GAD,LHGDN Detail
<0.001 endometrial hyperplasia NA BeFree Detail
0.005 endometriosis ARID1A and PIK3CA mutations appeared consistently in concurrent endometriosis wh... BeFree,GAD 25692284 Detail
0.005 endometriosis Distinct β-catenin and PIK3CA mutation profiles in endometriosis-associated ovar... BeFree,GAD 26276776 Detail
<0.001 Ependymoma NA BeFree Detail
0.007 Esophageal Neoplasms Therefore, concomitant blockage of the ErbB2-PI3K pathway and the Hedgehog downs... BeFree,LHGDN 25435423 Detail
<0.001 Exanthema NA BeFree Detail
<0.001 fetal alcohol syndrome NA BeFree Detail
<0.001 fibrosarcoma NA BeFree Detail
<0.001 fragile X syndrome NA BeFree Detail
0.002 Gingival Neoplasms NA GAD Detail
0.025 glioblastoma Moreover, TRIM24 regulates the expression of DNA repair enzyme O(6)-methylguanin... BeFree,LHGDN 24469053 Detail
0.025 glioblastoma ABT-263 (Navitoclax), an orally available small-molecule Bcl-2 inhibitor, and GD... BeFree,LHGDN 24757258 Detail
0.025 glioblastoma In this study, we used inhibitors to block specific signaling pathways, includin... BeFree,LHGDN 25048528 Detail
0.025 glioblastoma Application of a specific extracellular-related kinase 1/2 (ERK1/2) inhibitor, b... BeFree,LHGDN 25213694 Detail
0.025 glioblastoma However, due to the development of resistance mechanisms, kinase inhibition stud... BeFree,LHGDN 25256166 Detail
0.025 glioblastoma The EGFR and PI3K/mTORC1/2 pathways are frequently altered in glioblastoma (GBM)... BeFree,LHGDN 25316808 Detail
0.025 glioblastoma The activation of PI3K/Akt1 signaling pathway is involved in the proliferation o... BeFree,LHGDN 25501279 Detail
0.025 glioblastoma Further analyses revealed that Cyr61 seemed to activate PI3K/Akt/mTor signaling ... BeFree,LHGDN 25501701 Detail
0.025 glioblastoma We previously reported that decreased miR-218 expression in GBM directly promote... BeFree,LHGDN 25943352 Detail
0.010 Glioma TRIM24 promotes glioma progression and enhances chemoresistance through activati... BeFree 24469053 Detail
0.010 Glioma These results suggest that Liq treatment enhances glioma cell susceptibility to ... BeFree 25351348 Detail
0.010 Glioma Several studies have attempted to investigate the effects of combining the inhib... BeFree 25688137 Detail
0.010 Glioma The loss of MAGI3 expression in glioma may enhance the proliferation of glioma c... BeFree 26248734 Detail
0.120 IgA glomerulonephritis NA BeFree,CTD_human Detail
<0.001 granulosa cell tumor NA BeFree Detail
<0.001 Graves Disease NA BeFree Detail
0.120 Growth Disorders NA CTD_human Detail
<0.001 Hamartoma NA BeFree Detail
0.121 Hamartoma Syndrome, Multiple NA BeFree,ORPHANET Detail
<0.001 cardiac arrest ECCCs had SCA-like features with rare expression of estrogen receptor/progestero... BeFree 25473756 Detail
<0.001 Heart Diseases NA BeFree Detail
0.002 Heart failure NA BeFree Detail
0.002 congestive heart failure NA BeFree Detail
<0.001 Atrial Septal Defects NA BeFree Detail
<0.001 Hemangiosarcoma NA BeFree Detail
<0.001 hepatitis B NA BeFree Detail
0.003 hepatitis C NA BeFree,GAD Detail
<0.001 Herpes Simplex Infections NA BeFree Detail
<0.001 Von Hippel-Lindau syndrome NA BeFree Detail
<0.001 Histiocytosis, Langerhans-Cell NA BeFree Detail
0.004 HIV Infections NA BeFree,GAD Detail
<0.001 Hodgkin Disease NA BeFree Detail
<0.001 hyperglycemia NA BeFree Detail
<0.001 hyperinsulinism NA BeFree Detail
0.120 Hyperplasia NA CTD_human Detail
<0.001 hypoglycemia NA BeFree Detail
<0.001 Immunologic Deficiency Syndromes NA BeFree Detail
<0.001 Immune System Diseases This article highlights recent progress in characterizing the molecular mechanis... BeFree 25573003 Detail
0.001 influenza This novel mechanism of Dlg1 subversion by adenovirus to dysregulate PI3K could ... BeFree 24788832 Detail
<0.001 Intestinal Neoplasms NA BeFree Detail
<0.001 intestinal pseudo-obstruction NA BeFree Detail
0.002 ischemia In this study, we examined the effect of Ginsenoside Rb1 (GRb1) on ischemia/repe... BeFree 25257523 Detail
<0.001 Keloid NA BeFree Detail
<0.001 keratosis NA BeFree Detail
<0.001 Kidney Neoplasm NA BeFree Detail
<0.001 Klippel-Trenaunay-Weber Syndrome Most individuals from Boston Children's Hospital who had isolated LM (16/17) or ... BeFree 25681199 Detail
<0.001 leiomyosarcoma NA BeFree Detail
0.006 leukemia In the present study, we have shown for the first time that HBA decreased the ex... BeFree 25299784 Detail
0.006 leukemia The PI3K/Akt signaling pathway is constitutively activated in various leukemias. BeFree 26194899 Detail
0.004 chronic lymphocytic leukemia Altogether, these results underline the key role of PI3K/AKT pathway in the gene... BeFree 24825182 Detail
0.004 chronic lymphocytic leukemia The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelis... BeFree 25917267 Detail
<0.001 Acute Erythroblastic Leukemia NA BeFree Detail
<0.001 hairy cell leukemia NA BeFree Detail
0.002 Acute lymphocytic leukemia NA BeFree Detail
<0.001 Leukemia, Mast-Cell NA BeFree Detail
0.008 Leukemia, Myelocytic, Acute Importantly, emodin was demonstrated as a new inhibitor of PI3K/Akt in AML cells... BeFree 25174432 Detail
0.008 Leukemia, Myelocytic, Acute Inhibiting rescue pathways could improve the therapeutic efficacy of PI3K-target... BeFree 25322685 Detail
0.008 Leukemia, Myelocytic, Acute In the primary AML sample, we investigated the cell responses to ex vivo stimula... BeFree 25598437 Detail
0.008 Leukemia, Myelocytic, Acute The Ras/Raf/MAPK and PI3K/Akt/mTOR pathways are key signaling cascades involved ... BeFree 26044548 Detail
0.001 myeloid leukemia NA BeFree Detail
0.003 Myeloid Leukemia, Chronic The fusion gene bcr-abl develops chronic myeloid leukemia (CML), and stimulates ... BeFree 25644089 Detail
<0.001 Leukemia, Myeloid, Chronic-Phase NA BeFree Detail
<0.001 Leukemia, T-Cell NA BeFree Detail
<0.001 Adult T-Cell Lymphoma/Leukemia NA BeFree Detail
<0.001 lipodystrophy NA BeFree Detail
<0.001 lipoma NA BeFree Detail
<0.001 liposarcoma NA BeFree Detail
<0.001 liver cirrhosis NA BeFree Detail
<0.001 Liver diseases NA BeFree Detail
0.002 Liver neoplasms HBx induced AFP receptor expressed to activate PI3K/AKT signal to promote expres... BeFree 25943101 Detail
0.130 Lung Neoplasms NA BeFree,CTD_human,LHGDN Detail
<0.001 Lupus Erythematosus, Systemic NA BeFree Detail
0.003 lymphoma NA BeFree Detail
<0.001 Lymphoma, Follicular To clarify this point, biopsy tissue samples from 38 human FL cases were investi... BeFree 25096023 Detail
<0.001 Lymphoproliferative Disorders NA BeFree Detail
<0.001 Waldenstrom Macroglobulinemia NA BeFree Detail
0.016 Malignant neoplasm of stomach The AKT/mTOR pathway was activated by mutations of PIK3CA and PTPN11 in 4 GCs. BeFree,GAD 24510342 Detail
0.016 Malignant neoplasm of stomach In conclusion, knockdown of the c‑Met gene promoted gastric cancer cell apoptosi... BeFree,GAD 25395073 Detail
0.016 Malignant neoplasm of stomach Mechanically, PTP1B promotes gastric cancer cell proliferation, survival and inv... BeFree,GAD 25590580 Detail
0.016 Malignant neoplasm of stomach Therefore, our studies reveal for the first time that inhibition of the PI3K-Akt... BeFree,GAD 25640278 Detail
0.016 Malignant neoplasm of stomach Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Ak... BeFree,GAD 25727320 Detail
0.016 Malignant neoplasm of stomach Occurrence of low frequency PIK3CA and AKT2 mutations in gastric cancer. BeFree,GAD 25771729 Detail
0.016 Malignant neoplasm of stomach Identification of KRAS and PIK3CA but not BRAF mutations in patients with gastri... BeFree,GAD 25815786 Detail
0.016 Malignant neoplasm of stomach Everolimus monotherapy was satisfactory in a patient with refractory metastatic ... BeFree,GAD 25886409 Detail
0.005 Animal Mammary Neoplasms NA GAD Detail
0.002 Mandibular Neoplasms NA GAD Detail
<0.001 mastocytosis NA BeFree Detail
0.002 Maxillary Neoplasms NA GAD Detail
0.008 medulloblastoma Targeting the PI3K/AKT/mTOR signaling pathway in medulloblastoma. BeFree,LHGDN 25601471 Detail
0.008 medulloblastoma The Phosphoinositide 3-Kinase p110α Isoform Regulates Leukemia Inhibitory Factor... BeFree,LHGDN 25915540 Detail
<0.001 multiple endocrine neoplasia type 2B NA BeFree Detail
<0.001 meningioma NA BeFree Detail
0.001 Mesothelioma NA BeFree Detail
<0.001 Metabolic Diseases Recent attention has focused on the role of phosphatidylinositol 3-kinase (PI3K)... BeFree 25512233 Detail
<0.001 Mixed Salivary Gland Tumor NA BeFree Detail
<0.001 Monosomy NA BeFree Detail
0.122 Mouth Neoplasms NA CTD_human,GAD Detail
0.004 multiple myeloma Cancers like multiple myeloma (MM), which display elevated activity in key trans... BeFree 25197055 Detail
0.004 multiple myeloma Furthermore, our results demonstrated that the enforced expression of miR-145 in... BeFree 25369735 Detail
0.004 multiple myeloma Previously we showed that tetraspanin overexpression in MM cell lines attenuated... BeFree 25422161 Detail
<0.001 Mycobacterium Infections NA BeFree Detail
<0.001 mycosis fungoides In situ assessment of PI3K and PTEN alterations in mycosis fungoides: correlatio... BeFree 25267489 Detail
<0.001 myelofibrosis NA BeFree Detail
<0.001 Myeloproliferative disease Herein, we will review the clinically relevant inhibitors of the PI3K pathway th... BeFree 26062813 Detail
<0.001 myocardial infarction NA BeFree Detail
0.007 Nasopharyngeal Neoplasms NA BeFree,GAD Detail
<0.001 Neck Neoplasms NA BeFree Detail
0.005 Neoplasm Invasiveness NA GAD Detail
0.030 Neoplasm Metastasis Mechanistically, knockdown of FAP inactivated PTEN/PI3K/AKT and Ras-ERK and its ... BeFree,GAD,LHGDN 24722280 Detail
0.030 Neoplasm Metastasis IL-7 splicing variant IL-7δ5 induces EMT and metastasis of human breast cancer c... BeFree,GAD,LHGDN 24770666 Detail
0.030 Neoplasm Metastasis Molecular profiling of patient-matched brain and extracranial melanoma metastase... BeFree,GAD,LHGDN 24803579 Detail
0.030 Neoplasm Metastasis However, the mechanisms and specific functions of PI3K isoforms in tumor invasio... BeFree,GAD,LHGDN 24837077 Detail
0.030 Neoplasm Metastasis Mutations of KRAS and PIK3CA as independent predictors of distant metastases in ... BeFree,GAD,LHGDN 24861917 Detail
0.030 Neoplasm Metastasis NOX4 promotes non-small cell lung cancer cell proliferation and metastasis throu... BeFree,GAD,LHGDN 24946933 Detail
0.030 Neoplasm Metastasis Single cell mutational analysis of PIK3CA in circulating tumor cells and metasta... BeFree,GAD,LHGDN 24947048 Detail
0.030 Neoplasm Metastasis Yet, little is known concerning the role of the PI3K/Akt/Snail-dependent pathway... BeFree,GAD,LHGDN 25070581 Detail
0.030 Neoplasm Metastasis First-in-human study of CH5132799, an oral class I PI3K inhibitor, studying toxi... BeFree,GAD,LHGDN 25231405 Detail
0.030 Neoplasm Metastasis Overexpression of ribonuclease inhibitor defines good prognosis and suppresses p... BeFree,GAD,LHGDN 25257839 Detail
0.030 Neoplasm Metastasis These data indicate that the capacity of retinol to inhibit PI3K activity confer... BeFree,GAD,LHGDN 25356626 Detail
0.030 Neoplasm Metastasis These findings suggest that CEACAM6 enhances invasion and metastasis in GC by pr... BeFree,GAD,LHGDN 25398131 Detail
0.030 Neoplasm Metastasis PIK3CA hotspot mutations are present at a relatively high frequency in CTCs and ... BeFree,GAD,LHGDN 25398847 Detail
0.030 Neoplasm Metastasis These findings indicated that MALAT1 might suppress the tumor growth and metasta... BeFree,GAD,LHGDN 25431257 Detail
0.030 Neoplasm Metastasis In conclusion, this study suggested that EMT process can be triggered by the BMP... BeFree,GAD,LHGDN 25448881 Detail
0.030 Neoplasm Metastasis The EGFR/PI3K/PTEN/Akt/mTORC pathway plays prominent roles in malignant transfor... BeFree,GAD,LHGDN 25453219 Detail
0.030 Neoplasm Metastasis We sought to evaluate the impact of RAS and PIK3CA mutations on cumulative incid... BeFree,GAD,LHGDN 25491172 Detail
0.030 Neoplasm Metastasis SPOCK1 as a potential cancer prognostic marker promotes the proliferation and me... BeFree,GAD,LHGDN 25623055 Detail
0.030 Neoplasm Metastasis KRAS, BRAF and PIK3CA mutations are highly concordant between primary tumors and... BeFree,GAD,LHGDN 25639985 Detail
0.030 Neoplasm Metastasis The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR... BeFree,GAD,LHGDN 25677064 Detail
0.030 Neoplasm Metastasis Together, these results demonstrate that HGF/c-met can activate PI3K/Akt and dow... BeFree,GAD,LHGDN 25727320 Detail
0.030 Neoplasm Metastasis Mechanistic studies further revealed that VAV3 overexpression could dysregulate ... BeFree,GAD,LHGDN 25791293 Detail
0.030 Neoplasm Metastasis Prognostic value of PIK3CA mutation status, PTEN and androgen receptor expressio... BeFree,GAD,LHGDN 26247526 Detail
0.002 Neoplasm Recurrence, Local NA GAD Detail
<0.001 Embryonal Neoplasm NA BeFree Detail
<0.001 Neoplastic Syndromes, Hereditary NA BeFree Detail
<0.001 nephroblastoma NA BeFree Detail
<0.001 neurilemmoma We suggest that Nutlin-3, possibly in combination with FAK or PI3K inhibitors, c... BeFree 25217104 Detail
0.006 neuroblastoma Using the Snapshot assay, mutation statuses were detected for EGFR, Kirsten rate... BeFree 24823994 Detail
0.006 neuroblastoma Moreover, inhibitors of PI3K/mTOR and GLI signaling reduced neuroblastoma cell g... BeFree 25134527 Detail
0.006 neuroblastoma Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combinati... BeFree 25228590 Detail
0.006 neuroblastoma We previously demonstrated that PI3K Class IIβ (PI3KC2β) and its regulator inter... BeFree 25622909 Detail
<0.001 neurofibromatosis 1 NA BeFree Detail
0.002 obesity This integrated view of PI3K functions may ultimately help to develop new therap... BeFree 25512233 Detail
0.003 oligodendroglioma NA LHGDN Detail
<0.001 Degenerative polyarthritis NA BeFree Detail
0.004 osteosarcoma Knockdown of CXCR7 suppressed proliferation and invasion of OS cells through dec... BeFree 24969680 Detail
0.004 osteosarcoma The present results indicated that LY294002 inhibits the malignant phenotype of ... BeFree 25351625 Detail
0.004 osteosarcoma Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vul... BeFree 25512523 Detail
0.004 osteosarcoma In conclusion, icariin possesses a reversal effect on multidrug resistance in MG... BeFree 25747987 Detail
0.021 ovarian carcinoma Re-expression of ARHI in ovarian cancer cells blocks signaling through the PI3K ... BeFree 24769729 Detail
0.021 ovarian carcinoma MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth fa... BeFree 25176450 Detail
0.021 ovarian carcinoma Inhibiting the PI3K/AKT pathway may be a useful treatment for ovarian carcinoma. BeFree 25216292 Detail
0.021 ovarian carcinoma Moreover, LY294002, a potent and specific cell-permeable inhibitor of phosphatid... BeFree 25340291 Detail
0.021 ovarian carcinoma Gene mutation analysis showed that the cells belonged to the type II ovarian can... BeFree 25394645 Detail
0.021 ovarian carcinoma The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer. BeFree 25677064 Detail
0.009 Pancreatic Neoplasm NA BeFree,GAD,LHGDN Detail
<0.001 papilloma NA BeFree Detail
<0.001 paraganglioma NA BeFree Detail
0.120 Penile Neoplasms NA CTD_human Detail
0.003 Pharyngeal Neoplasms NA LHGDN Detail
<0.001 pheochromocytoma NA BeFree Detail
<0.001 pituitary adenoma NA BeFree Detail
<0.001 Pituitary Neoplasms NA BeFree Detail
<0.001 polycystic ovary syndrome In type 2 diabetes, obesity and PCOS, there is, although with some variation fro... BeFree 25123125 Detail
<0.001 polycythemia vera NA BeFree Detail
0.001 Adenomatous Polyposis Coli PTEN inactivation by mutation or allelic loss also occurs in CRCs. miR‑135b was ... BeFree 25571954 Detail
<0.001 polyps NA BeFree Detail
<0.001 Precancerous Conditions NA BeFree Detail
<0.001 Preleukemia NA BeFree Detail
0.122 Prostatic Neoplasms NA BeFree,CTD_human Detail
<0.001 pulmonary fibrosis NA BeFree Detail
0.005 Rectal Neoplasms NA GAD Detail
0.004 retinoblastoma Genome-wide analyses have identified four major signaling nodes that are most fr... BeFree,GAD 25070358 Detail
0.004 retinoblastoma PIK3R3, an isoform of class IA phosphoinositide 3-kinase (PI3K), specifically in... BeFree,GAD 25371235 Detail
0.002 rhabdomyosarcoma In the present study, we searched for combination therapies with the dual PI3K/m... BeFree 25637161 Detail
0.002 rhabdomyosarcoma Thus, combined GLI1/2 and PI3K/mTOR inhibition represents a promising novel appr... BeFree 25749378 Detail
0.004 Diabetes Mellitus, Non-Insulin-Dependent The aim of our study was to investigate whether common polymorphisms in the gene... BeFree 15127203 Detail
0.003 schizophrenia NA BeFree,GAD Detail
<0.001 systemic scleroderma NA BeFree Detail
<0.001 Seizures These data are the first to demonstrate that the inflammatory response induced b... BeFree 25903737 Detail
<0.001 Senile lentigo NA BeFree Detail
<0.001 Septicemia NA BeFree Detail
<0.001 Dermatologic disorders NA BeFree Detail
<0.001 Skin lesion We have already shown that AKT is activated in skin lesions in Mycosis Fungoides... BeFree 25267489 Detail
<0.001 Skin Neoplasms NA BeFree Detail
<0.001 Cerebrovascular accident In conclusion, IL-8 stimulates VEGF production in hBM-MSCs in part via the PI3K/... BeFree 24797366 Detail
<0.001 sudden infant death syndrome NA BeFree Detail
<0.001 syndactyly NA BeFree Detail
<0.001 synovial sarcoma NA BeFree Detail
0.002 thymoma NA BeFree Detail
0.020 Thyroid Neoplasm NA BeFree,GAD,LHGDN Detail
0.002 Tongue Neoplasms NA GAD Detail
<0.001 Chagas disease NA BeFree Detail
<0.001 tuberculosis NA BeFree Detail
0.003 tuberous sclerosis In addition, the phosphoinositide-3-kinase (PI3K)/Akt/mammalian target of rapamy... BeFree 25153728 Detail
<0.001 Attention Deficit Disorder NA BeFree Detail
<0.001 urticaria pigmentosa NA BeFree Detail
0.001 Virus Diseases The phosphatidylinositol-3-kinase (PI3K) and Akt pathway is activated in host im... BeFree 25158146 Detail
0.120 Weight Gain NA CTD_human Detail
0.007 B-Cell Lymphomas Many alterations directly or indirectly lead to activation of survival signaling... BeFree,LHGDN 24811162 Detail
0.007 B-Cell Lymphomas The oncogenic PI3K/serine-threonine kinase (PI3K/AKT) pathway is a downstream pa... BeFree,LHGDN 25862915 Detail
0.123 diffuse large B-cell lymphoma Inhibition of the PI3K/Akt/mTOR signaling pathway in diffuse large B-cell lympho... BeFree,CTD_human 25215588 Detail
<0.001 Lymphoma, T-Cell, Cutaneous NA BeFree Detail
<0.001 peripheral T-cell lymphoma We suggest that targeting the PI3K/AKT pathway may be a promising therapeutic st... BeFree 25862915 Detail
0.080 autosomal recessive polycystic kidney disease NA RGD Detail
<0.001 Liver failure NA BeFree Detail
0.001 acute leukemia NA BeFree Detail
<0.001 Rous Sarcoma NA BeFree Detail
<0.001 Squamous cell carcinoma of lung Prognostic significance of PIK3CA and SOX2 in Asian patients with lung squamous ... BeFree 25384882 Detail
0.002 Small cell carcinoma of lung This study reveals a critical role for the PTEN/PI3K pathway in both SCLC and lu... BeFree 24482365 Detail
0.002 Small cell carcinoma of lung The PI3K/AKT/mTOR pathway is distinguishable in SCLC genomic alterations. BeFree 25122428 Detail
<0.001 Thyroid Gland Follicular Adenoma NA BeFree Detail
<0.001 Oral Cavity Carcinoma NA BeFree Detail
<0.001 Myocardial Ischemia bFGF regulates autophagy and ubiquitinated protein accumulation induced by myoca... BeFree 25787015 Detail
<0.001 Cutaneous Melanoma NA BeFree Detail
0.123 Adenocarcinoma of lung (disorder) These data identify RIT1 as a driver oncogene in a specific subset of lung adeno... BeFree,CTD_human 24469055 Detail
0.123 Adenocarcinoma of lung (disorder) This study reveals a critical role for the PTEN/PI3K pathway in both SCLC and lu... BeFree,CTD_human 24482365 Detail
0.123 Adenocarcinoma of lung (disorder) Data were reviewed for patients with advanced lung adenocarcinomas enrolled in t... BeFree,CTD_human 25273224 Detail
0.123 Adenocarcinoma of lung (disorder) ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcin... BeFree,CTD_human 25596284 Detail
0.123 Adenocarcinoma of lung (disorder) Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of R... BeFree,CTD_human 26023239 Detail
0.002 esophageal carcinoma Therefore, concomitant blockage of the ErbB2-PI3K pathway and the Hedgehog downs... BeFree 25435423 Detail
0.002 esophageal carcinoma Immunohistochemical and molecular analysis of PI3K/AKT/mTOR pathway in esophagea... BeFree 25912437 Detail
0.001 Malignant neoplasm of mouth NA BeFree Detail
<0.001 Malignant neoplasm of oropharynx Reverse-phase protein array profiling of oropharyngeal cancer and significance o... BeFree 24599934 Detail
<0.001 Malignant neoplasm of nasopharynx NA BeFree Detail
<0.001 Malignant neoplasm of pharynx NA BeFree Detail
<0.001 Malignant neoplasm of gallbladder We found that activation of the PI3K/Akt pathway was involved in the oncogenic f... BeFree 25623055 Detail
0.001 uterine cancer Thus, Pten and Pik3ca have distinct consequences on the activation of the phosph... BeFree 25698082 Detail
<0.001 Malignant neoplasm of penis NA BeFree Detail
<0.001 Malignant neoplasm of brain NA BeFree Detail
<0.001 Secondary malignant neoplasm of lung The patient was treated with the PI(3)Kα inhibitor BYL719, which achieved a last... BeFree 25409150 Detail
<0.001 Secondary malignant neoplasm of bone NA BeFree Detail
<0.001 Obstructive chronic bronchitis with acute exacerbation NA BeFree Detail
<0.001 Vascular anomaly Most individuals from Boston Children's Hospital who had isolated LM (16/17) or ... BeFree 25681199 Detail
<0.001 Vascular anomaly PIK3CA-related overgrowth spectrum (PROS) include a group of disorders that affe... BeFree 25915946 Detail
<0.001 porphyria cutanea tarda NA BeFree Detail
0.003 Cicatrix, Hypertrophic NA LHGDN Detail
<0.001 Saethre-Chotzen syndrome NA BeFree Detail
<0.001 LEOPARD Syndrome NA BeFree Detail
0.005 Tumor Progression We propose the simultaneous activation of PLC-PKC-MEK1/2-ERK1/2 and PI3K pathway... BeFree 24909096 Detail
0.005 Tumor Progression These findings uncover a mechanism for constitutive PI3K/Akt activation in ESCC,... BeFree 25099196 Detail
0.005 Tumor Progression Our data showed that the PTEN/PI3K pathway was active in human ESCC tissues in v... BeFree 25175594 Detail
0.005 Tumor Progression The PI3K/AKT signal transduction pathway has distinct functional roles in tumor ... BeFree 25771729 Detail
<0.001 Anaplastic carcinoma NA BeFree Detail
<0.001 Undifferentiated carcinoma NA BeFree Detail
<0.001 Liposarcoma, Pleomorphic NA BeFree Detail
<0.001 Germ cell tumor FGFR3, AKT1, and PIK3CA mutations are all reported for the first time in GCT. BeFree 24812411 Detail
<0.001 Ki-1+ Anaplastic Large Cell Lymphoma In addition to the commonly known AP-1 activators Mitogen-Activated Protein Kina... BeFree 25961698 Detail
<0.001 hepatoblastoma Anticancer effect of calycopterin via PI3K/Akt and MAPK signaling pathways, ROS-... BeFree 25060910 Detail
<0.001 Liposarcoma, Myxoid NA BeFree Detail
<0.001 Rhabdomyosarcoma, Embryonal NA BeFree Detail
0.003 Adenocarcinoma, Clear Cell Compared with ovarian clear cell carcinomas, endometrial clear cell carcinomas s... BeFree 25081752 Detail
0.003 Adenocarcinoma, Clear Cell A patient with PIK3CA-mutated clear cell carcinoma of the ovary achieved a parti... BeFree 25231405 Detail
0.003 Adenocarcinoma, Clear Cell Crosstalk between PI3K and Ras pathways via protein phosphatase 2A in human ovar... BeFree 25756515 Detail
0.003 Adenocarcinoma, Clear Cell Distinct β-catenin and PIK3CA mutation profiles in endometriosis-associated ovar... BeFree 26276776 Detail
0.002 Papillary and follicular adenocarcinoma NA GAD Detail
0.002 Carcinoma, Endometrioid ECCCs had SCA-like features with rare expression of estrogen receptor/progestero... BeFree 25473756 Detail
0.002 Carcinoma, Endometrioid Preclinical investigations have suggested that the PI3K/AKT/mTOR pathway is freq... BeFree 25677064 Detail
0.002 Carcinoma, Endometrioid The efficacy of both PI3K and MEK inhibitors was evaluated in a model of endomet... BeFree 26232337 Detail
0.006 Carcinoma, Lobular NA BeFree,GAD,LHGDN Detail
0.001 cholangiocarcinoma NA BeFree Detail
0.002 Cystadenocarcinoma, Mucinous NA GAD Detail
0.004 Cystadenocarcinoma, Serous PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzu... BeFree,GAD 26325104 Detail
<0.001 Klatskin tumor NA BeFree Detail
<0.001 Cervical Intraepithelial Neoplasia Importantly, PIK3CA was altered in all MIC/CSCCs by either mutation or amplifica... BeFree 25738363 Detail
<0.001 Cervical Intraepithelial Neoplasia We studied a novel biomarker of human papillomavirus (HPV) life-cycle completion... BeFree 26379150 Detail
0.003 Rhabdoid Tumor NA BeFree,LHGDN Detail
0.001 Neuroendocrine Tumors Neuroendocrine cancer cell lines are used to investigate therapeutic targets in ... BeFree 26087898 Detail
<0.001 uveal melanoma NA BeFree Detail
0.002 Lip and oral cavity carcinoma NA BeFree Detail
<0.001 Metastatic malignant neoplasm to brain NA BeFree Detail
0.002 Macrocephaly Diagnostic descriptors associated with PIK3CA mutations include fibroadipose ove... BeFree 24782230 Detail
0.002 Macrocephaly Recently, somatic and germline variants in genes that are involved in the PI3K-A... BeFree 24939587 Detail
<0.001 Antisocial behavior NA BeFree Detail
<0.001 Extrapyramidal sign NA BeFree Detail
<0.001 gallbladder carcinoma We found that activation of the PI3K/Akt pathway was involved in the oncogenic f... BeFree 25623055 Detail
0.007 pancreatic carcinoma Further analysis showed that Cyr61 seemed to activate phosphatidylinositol 3-kin... BeFree 25104090 Detail
0.007 pancreatic carcinoma Recent data identify 3-phosphoinositide-dependent protein kinase 1 as a key tumo... BeFree 25152578 Detail
0.007 pancreatic carcinoma Activation of phosphoinositide-3 kinase (PI3K)-AKT-mammalian target of rapamycin... BeFree 25285629 Detail
0.007 pancreatic carcinoma Taken together, these data indicate that inhibition of MEK and PI3K alone or in ... BeFree 25376606 Detail
<0.001 Carcinoma of male breast NA BeFree Detail
0.002 Gastrointestinal Stromal Tumors microRNA-218 increase the sensitivity of gastrointestinal stromal tumor to imati... BeFree 24706111 Detail
0.002 Gastrointestinal Stromal Tumors We tested the in vivo efficacy of three PI3K inhibitors (PI3Ki) in patient-deriv... BeFree 25316817 Detail
<0.001 Cancer of Nasopharynx NA BeFree Detail
<0.001 Medullary carcinoma of thyroid PI3K/Akt/mTOR: A promising therapeutic target for non-medullary thyroid carcinom... BeFree 26138515 Detail
0.003 Papillary thyroid carcinoma Cribriform-morular variant of papillary thyroid carcinoma: a study of 3 cases fe... BeFree 26054797 Detail
0.021 Malignant neoplasm of lung Lung cancer TCGA data validated these findings and unveiled overlap of FGFR1 mRN... BeFree,GAD 24771645 Detail
0.021 Malignant neoplasm of lung RNA interference-mediated knockdown of RhoGDI2 induces the migration and invasio... BeFree,GAD 25266803 Detail
0.021 Malignant neoplasm of lung Data were reviewed for patients with advanced lung adenocarcinomas enrolled in t... BeFree,GAD 25273224 Detail
0.021 Malignant neoplasm of lung However, PIK3CA mutated lung cancer frequently develops in patients with prior m... BeFree,GAD 25473901 Detail
0.021 Malignant neoplasm of lung Common molecular drivers of lung cancer are mutations in receptor tyrosine kinas... BeFree,GAD 25524703 Detail
0.021 Malignant neoplasm of lung When the chimeric ubiquitin ligases were introduced into lung cancer SPC-A1 cell... BeFree,GAD 25573345 Detail
0.021 Malignant neoplasm of lung The altered PI3K/mTOR pathway is implicated in lung cancer, but mTOR inhibitors ... BeFree,GAD 25673697 Detail
0.021 Malignant neoplasm of lung It was found that AKT1 and PI3K/p85 expression was upregulated in LCSCs compared... BeFree,GAD 25738369 Detail
0.021 Malignant neoplasm of lung Hepatocyte growth factor (HGF) induces resistance to reversible and irreversible... BeFree,GAD 26063323 Detail
<0.001 age related macular degeneration NA BeFree Detail
<0.001 Malignant neoplasm of male breast NA BeFree Detail
<0.001 Systemic Inflammatory Response Syndrome NA BeFree Detail
<0.001 Sepsis NA BeFree Detail
<0.001 Carcinoma, Small Cell NA BeFree Detail
<0.001 Bannayan-Riley-Ruvalcaba syndrome NA BeFree Detail
<0.001 Cat eye syndrome NA BeFree Detail
<0.001 Congenital macrodactylia NA BeFree Detail
<0.001 polymicrogyria NA BeFree Detail
<0.001 Isovaleryl-CoA dehydrogenase deficiency NA BeFree Detail
<0.001 methylmalonic acidemia NA BeFree Detail
<0.001 Impaired glucose tolerance NA BeFree Detail
<0.001 Virchow's node (disorder) Genome-wide analyses have identified four major signaling nodes that are most fr... BeFree 25070358 Detail
0.001 Mastitis-metritis-agalactia syndrome NA BeFree Detail
<0.001 Familial Alzheimer Disease (FAD) NA BeFree Detail
<0.001 Stage II Colon Cancer NA BeFree Detail
0.004 Carcinoma breast stage IV Here we studied tumour genomic evolution in a patient (index patient) with metas... BeFree 25409150 Detail
0.004 Carcinoma breast stage IV The purpose of the study was to investigate the heterogeneity of PIK3CA mutation... BeFree 25539732 Detail
0.004 Carcinoma breast stage IV Here, resistance to a class I PI3K inhibitor in a model of metastatic breast can... BeFree 26058079 Detail
<0.001 Malignant neoplasm of stomach stage IV Successful control of heavily pretreated metastatic gastric cancer with the mTOR... BeFree 25886409 Detail
<0.001 Cervix carcinoma recurrent We analyzed the outcomes of patients with metastatic or recurrent cervical carci... BeFree 25426553 Detail
<0.001 inflammatory breast carcinoma Molecular aberrations affecting the PI3K pathway may play a role in the progress... BeFree 24634376 Detail
<0.001 gastric adenocarcinoma NA BeFree Detail
<0.001 Adenocarcinoma of small intestine PIK3CA mutations in small bowel adenocarcinoma. BeFree 25908046 Detail
<0.001 Stage IV Bladder Cancer AJCC v6 NA BeFree Detail
<0.001 Prostate cancer recurrent Activation of the PI3K/AKT signal pathway is a known driving force for the progr... BeFree 24983969 Detail
<0.001 adult glioblastoma NA BeFree Detail
<0.001 Metastatic melanoma Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prog... BeFree 25168062 Detail
0.001 Cancer of Head and Neck Reverse-phase protein array profiling of oropharyngeal cancer and significance o... BeFree 24599934 Detail
<0.001 Liver and Intrahepatic Biliary Tract Carcinoma NA BeFree Detail
<0.001 Lobular carcinoma in situ of breast Disruption in the E-cadherin complex is the hallmark of lobular lesions, but oth... BeFree 26041550 Detail
<0.001 B-cell adult acute lymphoblastic leukemia Our studies indicate that CK2-mediated PTEN posttranslational inactivation, asso... BeFree 24561792 Detail
0.121 Adenocarcinoma Of Esophagus ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal ... BeFree,CTD_human 25435423 Detail
<0.001 cervical squamous cell carcinoma In patients with squamous cell carcinoma of the cervix, the presence of PIK3CA m... BeFree 25426553 Detail
<0.001 cervical squamous cell carcinoma Genetic alterations of PIK3CA and tumor response in patients with locally advanc... BeFree 25773678 Detail
<0.001 Conventional (Clear Cell) Renal Cell Carcinoma Increased activity of PI3K/AKT/PMS2 could play a role in SETD2 mutated ccRCC. BeFree 26537074 Detail
0.005 Solid tumour First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phos... BeFree 25370471 Detail
0.005 Solid tumour BYL719, which selectively inhibits the alpha isoform of the phosphatidylinositol... BeFree 25544637 Detail
0.005 Solid tumour Phase I combination of pazopanib and everolimus in PIK3CA mutation positive/PTEN... BeFree 25902899 Detail
<0.001 stage, ovarian epithelial cancer NA BeFree Detail
<0.001 Squamous cell carcinoma of oropharynx PIK3CA mutations are more common in HPV(+) OPSCC and are associated with activat... BeFree 24599934 Detail
<0.001 uterine carcinosarcoma Molecular alterations of PIK3CA in uterine carcinosarcoma, clear cell, and serou... BeFree 25078343 Detail
<0.001 Adenocarcinoma of pancreas NA BeFree Detail
<0.001 desmoplastic small round cell tumor Novel somatic mutations were identified in four out of 18 patients with advanced... BeFree 25119929 Detail
<0.001 Prostatic Intraepithelial Neoplasias NA BeFree Detail
0.005 cervix carcinoma Taken together, our data suggest that anti-VEGFa treatment in cervical cancer ma... BeFree 25135429 Detail
0.005 cervix carcinoma CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical ... BeFree 25310288 Detail
0.005 cervix carcinoma Peroxisome proliferator-activated receptor-gamma agonist 4-O-methylhonokiol indu... BeFree 25563418 Detail
0.005 cervix carcinoma The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein is pr... BeFree 25738254 Detail
0.005 cervix carcinoma Butein suppresses cervical cancer growth through the PI3K/AKT/mTOR pathway. BeFree 25962638 Detail
<0.001 Stucco keratosis NA BeFree Detail
<0.001 Congenital hypertrophy Unlike Proteus syndrome, 31/35 (89%) patients with PIK3CA mutations had congenit... BeFree 24782230 Detail
<0.001 Congenital hemihypertrophy Diagnostic descriptors associated with PIK3CA mutations include fibroadipose ove... BeFree 24782230 Detail
<0.001 Congenital hemihypertrophy PIK3CA-related overgrowth spectrum (PROS) include a group of disorders that affe... BeFree 25915946 Detail
<0.001 Carcinoid tumor no ICD-O subtype NA BeFree Detail
<0.001 cystadenofibroma NA BeFree Detail
<0.001 Ceruminous adenoma NA BeFree Detail
<0.001 Non-infiltrating lobular carcinoma Disruption in the E-cadherin complex is the hallmark of lobular lesions, but oth... BeFree 26041550 Detail
<0.001 Round cell liposarcoma NA BeFree Detail
<0.001 Proliferating Brenner Tumor NA BeFree Detail
<0.001 anaplastic astrocytoma NA BeFree Detail
<0.001 pilocytic astrocytoma NA BeFree Detail
<0.001 anaplastic oligodendroglioma NA BeFree Detail
0.003 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse NA BeFree Detail
<0.001 Adenocarcinoma of colon In this study, the inhibitory effect of KYNA on activation of phosphoinositide 3... BeFree 25012123 Detail
<0.001 Impaired cognition NA BeFree Detail
<0.001 Capillary malformation (disorder) Historically, the clinical diagnoses in patients with PIK3CA activating mutation... BeFree 25557259 Detail
<0.001 Capillary malformation (disorder) PIK3CA-related overgrowth spectrum (PROS) include a group of disorders that affe... BeFree 25915946 Detail
<0.001 endometriosis of uterus The aim of this study was to investigate the role of miR-10b and its target gene... BeFree 25896413 Detail
<0.001 Human papilloma virus infection The data indicate that CIN genomes harbor unfixed mutations in addition to human... BeFree 25738363 Detail
<0.001 Malignant neoplasm of liver NA BeFree Detail
<0.001 malignant mesothelioma NA BeFree Detail
<0.001 Malignant Mesothelioma of Peritoneum Targeted, massively parallel DNA sequencing and molecular inversion probe microa... BeFree 25588929 Detail
<0.001 Endometrioid carcinoma ovary PIK3CA mutations were observed in 11 (31.4%) of 35 OEMCas and 10 (35.7%) of 28 O... BeFree 26276776 Detail
<0.001 Vulval intraepithelial neoplasia NA BeFree Detail
<0.001 Multiple malignancy Finally, we provide evidence that APOBEC activity is responsible for the generat... BeFree 24910434 Detail
0.008 Malignant neoplasm of pancreas Recent data identify 3-phosphoinositide-dependent protein kinase 1 as a key tumo... BeFree 25152578 Detail
0.008 Malignant neoplasm of pancreas Activation of phosphoinositide-3 kinase (PI3K)-AKT-mammalian target of rapamycin... BeFree 25285629 Detail
0.008 Malignant neoplasm of pancreas Taken together, these data indicate that inhibition of MEK and PI3K alone or in ... BeFree 25376606 Detail
<0.001 Disseminated Malignant Neoplasm First-in-human study of CH5132799, an oral class I PI3K inhibitor, studying toxi... BeFree 25231405 Detail
<0.001 Squamous cell carcinoma of tongue NA BeFree Detail
<0.001 juvenile myelomonocytic leukemia Juvenile myelomonocytic leukaemia-associated mutation in Cbl promotes resistance... BeFree 24469048 Detail
0.020 Malignant neoplasm of prostate We identified differential therapeutic vulnerabilities that emerge upon the loss... BeFree,GAD 24866151 Detail
0.020 Malignant neoplasm of prostate A genome-wide RNAi screen identifies FOXO4 as a metastasis-suppressor through co... BeFree,GAD 24983969 Detail
0.020 Malignant neoplasm of prostate The impact of miRNA on the canonical TGF-β Smad signalling pathway has been well... BeFree,GAD 24985060 Detail
0.020 Malignant neoplasm of prostate Restoration of PTEN expression or inhibition of PI3K action decreased cPLA₂α exp... BeFree,GAD 25026288 Detail
0.020 Malignant neoplasm of prostate Genome-wide analyses have identified four major signaling nodes that are most fr... BeFree,GAD 25070358 Detail
0.020 Malignant neoplasm of prostate Targeting the PI3K/Akt pathway in prostate cancer: challenges and opportunities ... BeFree,GAD 25120209 Detail
0.020 Malignant neoplasm of prostate The findings from this study suggest that the combination of dual PI3K/Akt/mTOR ... BeFree,GAD 25275598 Detail
0.020 Malignant neoplasm of prostate Co-targeting AR and PI3K/AKT signaling has been proposed to be a more effective ... BeFree,GAD 25360799 Detail
0.020 Malignant neoplasm of prostate The Upregulation of PI3K/Akt and MAP Kinase Pathways is Associated with Resistan... BeFree,GAD 25640606 Detail
0.020 Malignant neoplasm of prostate Among the cancer networks and STNs we considered, it is found that there is a su... BeFree,GAD 25707690 Detail
0.001 Hematologic Neoplasms NA BeFree Detail
<0.001 Chorea Acanthocytosis Syndrome NA BeFree Detail
<0.001 Lymphatic Abnormalities Activating PIK3CA alleles and lymphangiogenic phenotype of lymphatic endothelial... BeFree 25292196 Detail
<0.001 Lymphatic Abnormalities Somatic PIK3CA mutations are the most common cause of isolated LMs and disorders... BeFree 25681199 Detail
0.121 Hemimegalencephaly NA BeFree,ORPHANET Detail
<0.001 Microinvasive carcinoma Importantly, PIK3CA was altered in all MIC/CSCCs by either mutation or amplifica... BeFree 25738363 Detail
<0.001 Endometrioid tumor Endometrial cancers have been recently molecularly characterized; amplifications... BeFree 24820961 Detail
0.017 endometrial carcinoma Evidence for different expression profiles for c-Met, EGFR, PTEN and the mTOR pa... BeFree 24811063 Detail
0.017 endometrial carcinoma PIK3CA mutations are commonly found in endometrial cancers. BeFree 25078343 Detail
0.017 endometrial carcinoma The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal tra... BeFree 25141911 Detail
0.017 endometrial carcinoma This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pa... BeFree 25301678 Detail
0.017 endometrial carcinoma Targeted, massively parallel DNA sequencing and molecular inversion probe microa... BeFree 25588929 Detail
0.017 endometrial carcinoma The phosphoinositol-3 kinase (PI3K) pathway is frequently dysregulated in endome... BeFree 25624430 Detail
0.017 endometrial carcinoma Activated mutant p110α causes endometrial carcinoma in the setting of biallelic ... BeFree 25698082 Detail
0.017 endometrial carcinoma PIKing the type and pattern of PI3K pathway mutations in endometrioid endometria... BeFree 25701704 Detail
0.017 endometrial carcinoma NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activat... BeFree 26193427 Detail
0.001 Secondary malignant neoplasm of liver NA BeFree Detail
<0.001 dementia NA BeFree Detail
<0.001 Recurrent tumor However, the significance of PIK3CA gene alterations with respect to clinicopath... BeFree 24347284 Detail
<0.001 Recurrent tumor Other molecular alterations, like mTOR or PI3K pathway deregulation, or Matrilin... BeFree 24554201 Detail
<0.001 Increased drug resistance NA BeFree Detail
<0.001 Metabolic syndrome X NA BeFree Detail
0.002 Retinal Neoplasms NA GAD Detail
<0.001 Neurodegenerative Disorders NA BeFree Detail
<0.001 Mood Disorders NA BeFree Detail
<0.001 Myxoid/Round Cell Liposarcoma NA BeFree Detail
0.006 Malignant neoplasm of esophagus Therefore, concomitant blockage of the ErbB2-PI3K pathway and the Hedgehog downs... BeFree,GAD 25435423 Detail
0.010 Thyroid carcinoma The present review focuses on the most recent developments on the role of the PI... BeFree,GAD 26138515 Detail
0.001 Ewings sarcoma Novel somatic mutations were identified in four out of 18 patients with advanced... BeFree 25119929 Detail
0.001 Ewings sarcoma We further show that expression of PTEN, a well-established, potent tumor suppre... BeFree 25603314 Detail
<0.001 Oropharyngeal disorders We identified frequent PIK3CA mutations in patients with high-risk HNSCC confine... BeFree 23852799 Detail
<0.001 Squamous cell carcinoma of skin Y-box Binding Protein-1 Is Part of a Complex Molecular Network Linking ΔNp63α to... BeFree 25639555 Detail
<0.001 Malignant glioma NA BeFree Detail
<0.001 Tonsillar Carcinoma Divergence of P53, PTEN, PI3K, Akt and mTOR expression in tonsillar cancer. BeFree 24616007 Detail
<0.001 Infected ascites NA BeFree Detail
0.004 Osteosarcoma of bone Knockdown of CXCR7 suppressed proliferation and invasion of OS cells through dec... BeFree 24969680 Detail
0.004 Osteosarcoma of bone The present results indicated that LY294002 inhibits the malignant phenotype of ... BeFree 25351625 Detail
0.004 Osteosarcoma of bone Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vul... BeFree 25512523 Detail
0.004 Osteosarcoma of bone In conclusion, icariin possesses a reversal effect on multidrug resistance in MG... BeFree 25747987 Detail
<0.001 Costello syndrome (disorder) Costello syndrome (CS) is a rare genetic disorder caused, in the majority of cas... BeFree 25367099 Detail
<0.001 Carcinoma of larynx NA BeFree Detail
0.002 Leukemogenesis NA BeFree Detail
0.001 Tumor Initiation NA BeFree Detail
0.017 prostate carcinoma We identified differential therapeutic vulnerabilities that emerge upon the loss... BeFree 24866151 Detail
0.017 prostate carcinoma A genome-wide RNAi screen identifies FOXO4 as a metastasis-suppressor through co... BeFree 24983969 Detail
0.017 prostate carcinoma The impact of miRNA on the canonical TGF-β Smad signalling pathway has been well... BeFree 24985060 Detail
0.017 prostate carcinoma Restoration of PTEN expression or inhibition of PI3K action decreased cPLA₂α exp... BeFree 25026288 Detail
0.017 prostate carcinoma Genome-wide analyses have identified four major signaling nodes that are most fr... BeFree 25070358 Detail
0.017 prostate carcinoma Targeting the PI3K/Akt pathway in prostate cancer: challenges and opportunities ... BeFree 25120209 Detail
0.017 prostate carcinoma The findings from this study suggest that the combination of dual PI3K/Akt/mTOR ... BeFree 25275598 Detail
0.017 prostate carcinoma Co-targeting AR and PI3K/AKT signaling has been proposed to be a more effective ... BeFree 25360799 Detail
0.017 prostate carcinoma The Upregulation of PI3K/Akt and MAP Kinase Pathways is Associated with Resistan... BeFree 25640606 Detail
0.017 prostate carcinoma Among the cancer networks and STNs we considered, it is found that there is a su... BeFree 25707690 Detail
0.128 Epithelial ovarian cancer Inhibiting the PI3K/AKT pathway may be a useful treatment for ovarian carcinoma. BeFree,CLINVAR,GAD 25216292 Detail
0.128 Epithelial ovarian cancer In conclusion, the results of the present study demonstrated that PI3K/AKT and R... BeFree,CLINVAR,GAD 25405658 Detail
0.128 Epithelial ovarian cancer These findings revealed that miR‑338‑3p may act as a tumor suppressor that block... BeFree,CLINVAR,GAD 25776272 Detail
<0.001 invasive cancer Therefore, the hyperactivity of PI3K/Akt pathway and elevated levels of p53R2 ca... BeFree 25086499 Detail
<0.001 Progressive Neoplastic Disease NA BeFree Detail
<0.001 Refractory cancer Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor. BeFree 25409150 Detail
<0.001 Sentinel node (disorder) NA BeFree Detail
0.012 Carcinoma of lung Lung cancer TCGA data validated these findings and unveiled overlap of FGFR1 mRN... BeFree 24771645 Detail
0.012 Carcinoma of lung RNA interference-mediated knockdown of RhoGDI2 induces the migration and invasio... BeFree 25266803 Detail
0.012 Carcinoma of lung Data were reviewed for patients with advanced lung adenocarcinomas enrolled in t... BeFree 25273224 Detail
0.012 Carcinoma of lung However, PIK3CA mutated lung cancer frequently develops in patients with prior m... BeFree 25473901 Detail
0.012 Carcinoma of lung Common molecular drivers of lung cancer are mutations in receptor tyrosine kinas... BeFree 25524703 Detail
0.012 Carcinoma of lung When the chimeric ubiquitin ligases were introduced into lung cancer SPC-A1 cell... BeFree 25573345 Detail
0.012 Carcinoma of lung The altered PI3K/mTOR pathway is implicated in lung cancer, but mTOR inhibitors ... BeFree 25673697 Detail
0.012 Carcinoma of lung It was found that AKT1 and PI3K/p85 expression was upregulated in LCSCs compared... BeFree 25738369 Detail
0.012 Carcinoma of lung Hepatocyte growth factor (HGF) induces resistance to reversible and irreversible... BeFree 26063323 Detail
0.003 Secondary malignant neoplasm of lymph node Our data showed that the PTEN/PI3K pathway was active in human ESCC tissues in v... BeFree 25175594 Detail
0.003 Secondary malignant neoplasm of lymph node The frequency of mutations in either KRAS or PIK3CA were significantly higher in... BeFree 25815786 Detail
<0.001 Cancer Relapse NA BeFree Detail
0.131 colon carcinoma Synergism of PI3K/Akt inhibition and Fas activation on colon cancer cell death. BeFree,CLINVAR 25199763 Detail
0.131 colon carcinoma Fifteen genes (DUSP2, INFGR1, IL6, IRF2, JAK2, MAP3K10, MMP1, NFkB1A, NOS2A, PIK... BeFree,CLINVAR 25541970 Detail
0.131 colon carcinoma Quinazoline based small molecule exerts potent tumour suppressive properties by ... BeFree,CLINVAR 25554016 Detail
0.131 colon carcinoma PIK3CA mutations predict recurrence in localized microsatellite stable colon can... BeFree,CLINVAR 25641861 Detail
0.131 colon carcinoma In the present study, the expression status of miR-218 and the role of the phosp... BeFree,CLINVAR 25760926 Detail
0.131 colon carcinoma This study aims to characterize colon cancer with regard to KRAS, BRAF, and PIK3... BeFree,CLINVAR 25884297 Detail
0.131 colon carcinoma Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway gene... BeFree,CLINVAR 25889965 Detail
0.131 colon carcinoma Here, we detected its effects on DLD-1 and SW480 (two human colon cancer cell li... BeFree,CLINVAR 26225471 Detail
0.014 stomach carcinoma The AKT/mTOR pathway was activated by mutations of PIK3CA and PTPN11 in 4 GCs. BeFree 24510342 Detail
0.014 stomach carcinoma These data suggest that EGF-induced activation of MMP7 and MMP13 in GC is throug... BeFree 25085584 Detail
0.014 stomach carcinoma In conclusion, knockdown of the c‑Met gene promoted gastric cancer cell apoptosi... BeFree 25395073 Detail
0.014 stomach carcinoma Mechanically, PTP1B promotes gastric cancer cell proliferation, survival and inv... BeFree 25590580 Detail
0.014 stomach carcinoma Therefore, our studies reveal for the first time that inhibition of the PI3K-Akt... BeFree 25640278 Detail
0.014 stomach carcinoma Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Ak... BeFree 25727320 Detail
0.014 stomach carcinoma Occurrence of low frequency PIK3CA and AKT2 mutations in gastric cancer. BeFree 25771729 Detail
0.014 stomach carcinoma Identification of KRAS and PIK3CA but not BRAF mutations in patients with gastri... BeFree 25815786 Detail
0.014 stomach carcinoma Everolimus monotherapy was satisfactory in a patient with refractory metastatic ... BeFree 25886409 Detail
0.004 Carcinoma of bladder PIK3CA gene alterations in bladder cancer are frequent and associate with reduce... BeFree 24347284 Detail
0.004 Carcinoma of bladder Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential us... BeFree 24929024 Detail
0.004 Carcinoma of bladder Our findings suggest that miR-21 acts as a molecular switch to regulate aerobic ... BeFree 25266796 Detail
0.004 Carcinoma of bladder Taken together, EN2 may be a candidate oncogene in BC by activating the PI3K/Akt... BeFree 25812440 Detail
<0.001 Malignant Female Reproductive System Neoplasm This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pa... BeFree 25301678 Detail
<0.001 skin carcinoma NA BeFree Detail
0.006 Central neuroblastoma Using the Snapshot assay, mutation statuses were detected for EGFR, Kirsten rate... BeFree 24823994 Detail
0.006 Central neuroblastoma Moreover, inhibitors of PI3K/mTOR and GLI signaling reduced neuroblastoma cell g... BeFree 25134527 Detail
0.006 Central neuroblastoma Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combinati... BeFree 25228590 Detail
0.006 Central neuroblastoma We previously demonstrated that PI3K Class IIβ (PI3KC2β) and its regulator inter... BeFree 25622909 Detail
<0.001 Malignant neoplasm of kidney NA BeFree Detail
<0.001 Pharyngeal Carcinoma NA BeFree Detail
<0.001 biliary tract cancer Targeted inhibition of the PI3K/mTOR and Hhpathways indicates a new avenue for B... BeFree 25742482 Detail
<0.001 Malignant neoplasm tonsil Divergence of P53, PTEN, PI3K, Akt and mTOR expression in tonsillar cancer. BeFree 24616007 Detail
<0.001 Cancer of Urinary Tract NA BeFree Detail
<0.001 Malignant Squamous Cell Neoplasm NA BeFree Detail
0.001 malignant pleural mesothelioma MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant p... BeFree 25221930 Detail
<0.001 Metastatic Endometrial Carcinoma NA BeFree Detail
<0.001 Heartburn acidity NA BeFree Detail
<0.001 Helicobacter pylori infection Inhibition of PI3K and Akt kinase prevented the phosphorylation of 4E-BP1, sugge... BeFree 25194338 Detail
<0.001 penis carcinoma NA BeFree Detail
0.003 Invasive breast carcinoma PI3K pathway activation in high-grade ductal carcinoma in situ--implications for... BeFree 24634376 Detail
<0.001 Metastases to adrenals NA BeFree Detail
0.002 Rhabdoid Tumor of the Kidney Our model allowed us to test the contributions of oncogenes in the RTK/RAS/PI(3)... BeFree 24752661 Detail
0.002 Rhabdoid Tumor of the Kidney These and their respective parent cell lines were tested for sensitivity to erlo... BeFree 24895459 Detail
<0.001 Diffuse large B-cell lymphoma recurrent NA BeFree Detail
<0.001 Philadelphia chromosome positive NA BeFree Detail
<0.001 dedifferentiated chondrosarcoma NA BeFree Detail
<0.001 Hyperkeratosis NA BeFree Detail
<0.001 latent infection NA BeFree Detail
<0.001 Advanced cancer NA BeFree Detail
<0.001 Cardiomyopathies NA BeFree Detail
<0.001 Erdheim-Chester disease NA BeFree Detail
<0.001 SHORT syndrome NA BeFree Detail
<0.001 Cerebral Ischemia NA BeFree Detail
0.002 Microsatellite Instability NA GAD Detail
<0.001 cancer recurrence NA BeFree Detail
<0.001 Metastatic Prostate Carcinoma NA BeFree Detail
0.006 Colorectal cancer metastatic The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatmen... BeFree 24666267 Detail
0.006 Colorectal cancer metastatic Although epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) cetux... BeFree 25326806 Detail
0.006 Colorectal cancer metastatic Comparison of neuroendocrine differentiation and KRAS/NRAS/BRAF/PIK3CA/TP53 muta... BeFree 25337237 Detail
0.006 Colorectal cancer metastatic We performed a computerized search of the electronic medical record of our insti... BeFree 25491172 Detail
0.006 Colorectal cancer metastatic A retrospective observational study of clinicopathological features of KRAS, NRA... BeFree 25886136 Detail
<0.001 Polyp of large intestine NA BeFree Detail
<0.001 Drug Resistant Epilepsy In this study we performed multiplex targeted sequencing of 10 genes in the PI3K... BeFree 25722288 Detail
0.002 Invasive Ductal Breast Carcinoma NA GAD Detail
0.145 Malignant neoplasm of ovary Re-expression of ARHI in ovarian cancer cells blocks signaling through the PI3K ... BeFree,GAD,UNIPROT 24769729 Detail
0.145 Malignant neoplasm of ovary MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth fa... BeFree,GAD,UNIPROT 25176450 Detail
0.145 Malignant neoplasm of ovary Moreover, LY294002, a potent and specific cell-permeable inhibitor of phosphatid... BeFree,GAD,UNIPROT 25340291 Detail
0.145 Malignant neoplasm of ovary Gene mutation analysis showed that the cells belonged to the type II ovarian can... BeFree,GAD,UNIPROT 25394645 Detail
0.145 Malignant neoplasm of ovary The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer. BeFree,GAD,UNIPROT 25677064 Detail
<0.001 High-Grade Prostatic Intraepithelial Neoplasia NA BeFree Detail
0.008 Squamous cell carcinoma of the head and neck We identified frequent PIK3CA mutations in patients with high-risk HNSCC confine... BeFree 23852799 Detail
0.008 Squamous cell carcinoma of the head and neck The purpose of this study was to determine whether single nucleotide polymorphis... BeFree 24421178 Detail
0.008 Squamous cell carcinoma of the head and neck A comprehensive evaluation of biomarkers predictive of response to PI3K inhibito... BeFree 25193510 Detail
0.008 Squamous cell carcinoma of the head and neck Emphasis is placed on the therapeutic implications of genes frequently altered i... BeFree 25440877 Detail
0.008 Squamous cell carcinoma of the head and neck Response of head and neck squamous cell carcinoma cells carrying PIK3CA mutation... BeFree 25855885 Detail
0.004 Ductal Carcinoma NA BeFree,LHGDN Detail
<0.001 Mammary Carcinoma, Human NA BeFree Detail
<0.001 Morphologically altered structure NA BeFree Detail
<0.001 attention deficit hyperactivity disorder NA BeFree Detail
<0.001 Enterochromaffin-like cell carcinoid NA BeFree Detail
<0.001 Atypical teratoid/rhabdoid tumor NA BeFree Detail
<0.001 Primary Effusion Lymphoma NA BeFree Detail
<0.001 Chronic myeloproliferative disorder Herein, we will review the clinically relevant inhibitors of the PI3K pathway th... BeFree 26062813 Detail
<0.001 Pancreatic intraepithelial neoplasia NA BeFree Detail
<0.001 Salivary duct carcinoma NA BeFree Detail
<0.001 Squamous cell carcinoma of pharynx NA BeFree Detail
<0.001 Sendai virus infection Our results show that Sendai virus infection, which is recognized by RIG-I, led ... BeFree 25158146 Detail
<0.001 Hormone refractory prostate cancer NA BeFree Detail
<0.001 Adenoid cystic breast carcinoma NA BeFree Detail
<0.001 Atypical Ductal Breast Hyperplasia NA BeFree Detail
<0.001 Classical Hodgkin's Lymphoma NA BeFree Detail
<0.001 Cystic Neoplasm NA BeFree Detail
<0.001 Epstein-Barr Virus-Related Lymphoma NA BeFree Detail
<0.001 External Auditory Canal Ceruminous Adenoma NA BeFree Detail
<0.001 Flat Ductal Epithelial Atypia of the Breast NA BeFree Detail
0.121 Hereditary Nonpolyposis Colorectal Cancer NA BeFree,ORPHANET Detail
<0.001 Invasive Carcinoma NA BeFree Detail
<0.001 Mucinous carcinoma of breast NA BeFree Detail
<0.001 Mucinous Neoplasm NA BeFree Detail
0.002 Necrotic changes (finding) NA GAD Detail
<0.001 Ovarian Serous Adenocarcinoma NA BeFree Detail
<0.001 Sporadic Breast Carcinoma NA BeFree Detail
<0.001 Testicular Germ Cell Tumor NA BeFree Detail
<0.001 differentiated thyroid gland carcinoma NA BeFree Detail
<0.001 Granulosa cell tumor of the ovary NA BeFree Detail
0.001 renal carcinoma Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-indu... BeFree 24743574 Detail
<0.001 Metastatic Carcinoma Targeted PI3K/AKT/mTOR therapy for metastatic carcinomas of the cervix: A phase ... BeFree 25426553 Detail
<0.001 anal squamous cell carcinoma NA BeFree Detail
<0.001 Cardiomyopathy, Familial Idiopathic NA BeFree Detail
0.171 Mammary Neoplasms We validated the top ranking genes, i.e., PIK3CA and PIK3CB, by showing that the... BeFree,CTD_human,GAD,LHGDN 25195596 Detail
0.171 Mammary Neoplasms Activating mutations of PIK3CA are the most frequent genomic alterations in estr... BeFree,CTD_human,GAD,LHGDN 25877889 Detail
0.171 Mammary Neoplasms Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogen... BeFree,CTD_human,GAD,LHGDN 26266985 Detail
<0.001 Angiogenic Switch NA BeFree Detail
<0.001 Breast Cancer Model NA BeFree Detail
<0.001 Hepatocarcinogenesis NA BeFree Detail
<0.001 Mammary Tumorigenesis NA BeFree Detail
0.001 Cancer Cell Growth NA BeFree Detail
<0.001 Serous Endometrial Intraepithelial Carcinoma NA BeFree Detail
<0.001 ovarian clear cell adenocarcinoma NA BeFree Detail
0.002 Tumor Angiogenesis The tumor suppressor WIF1 was also found to be capable of suppressing tumor grow... BeFree 25086206 Detail
0.002 Tumor Angiogenesis Increased CYP4Z2P- and CYP4Z1-3'UTR expression promotes tumor angiogenesis in br... BeFree 25701119 Detail
<0.001 Tumor Promotion NA BeFree Detail
0.003 Xenograft Model The combination of HER2 inhibitors with PI3K inhibition was studied in HER2-ampl... BeFree 24451154 Detail
0.003 Xenograft Model Using AR + TNBC cell line and xenograft models we evaluated the effectiveness of... BeFree 25103565 Detail
0.003 Xenograft Model In addition, the phosphoinositide-3-kinase (PI3K)/Akt/mammalian target of rapamy... BeFree 25153728 Detail
0.003 Xenograft Model We tested the in vivo efficacy of three PI3K inhibitors (PI3Ki) in patient-deriv... BeFree 25316817 Detail
0.003 Xenograft Model In this study, we investigated the mechanisms of AZD6244 alone or with BEZ235, a... BeFree 25326806 Detail
0.003 Ductal Breast Carcinoma NA BeFree,GAD Detail
<0.001 Rash and Dermatitis Adverse Event Associated with Chemoradiation NA BeFree Detail
<0.001 Progesterone receptor positive tumor An enrichment of PIK3CA exon 20 mutations was observed in progesterone receptor-... BeFree 24467828 Detail
<0.001 Adenocarcinoma, Endometrioid ECCCs had SCA-like features with rare expression of estrogen receptor/progestero... BeFree 25473756 Detail
<0.001 Adenocarcinoma, Endometrioid Preclinical investigations have suggested that the PI3K/AKT/mTOR pathway is freq... BeFree 25677064 Detail
0.002 Glioblastoma multiforme Here, using specific inhibitors, we found that the activation of EGFR signaling ... BeFree 25431263 Detail
0.002 Glioblastoma multiforme The phosphoinositide 3-kinase (PI3K)/Akt/PTEN signaling pathway is deregulated i... BeFree 25501707 Detail
<0.001 Cirrhosis NA BeFree Detail
<0.001 androgen independent prostate cancer NA BeFree Detail
<0.001 tumor vasculature Important mechanisms we discuss include (1) improved DNA repair in normal, but n... BeFree 24436017 Detail
<0.001 Uterine Corpus Carcinosarcoma Molecular alterations of PIK3CA in uterine carcinosarcoma, clear cell, and serou... BeFree 25078343 Detail
<0.001 Columnar Cell Change of the Breast NA BeFree Detail
<0.001 Idiopathic Pulmonary Fibrosis NA BeFree Detail
<0.001 Familial ependymoma NA BeFree Detail
0.001 ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1 Our findings warrant further investigation of the role of different types of PIK... BeFree 25701704 Detail
<0.001 Prostate Cancer, Hereditary, 7 NA BeFree Detail
<0.001 HEMIHYPERPLASIA, ISOLATED Diagnostic descriptors associated with PIK3CA mutations include fibroadipose ove... BeFree 24782230 Detail
<0.001 HEMIHYPERPLASIA, ISOLATED PIK3CA-related overgrowth spectrum (PROS) include a group of disorders that affe... BeFree 25915946 Detail
<0.001 Breast Cancer, Familial Male NA BeFree Detail
0.120 Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome NA BeFree,CTD_human Detail
0.360 Megalencephaly cutis marmorata telangiectatica congenita Germline PTPN11 and somatic PIK3CA variant in a boy with megalencephaly-capillar... BeFree,CLINVAR,ORPHANET,UNIPROT 24939587 Detail
0.009 uterine corpus cancer PIK3CA mutations are commonly found in endometrial cancers. BeFree 25078343 Detail
0.009 uterine corpus cancer The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal tra... BeFree 25141911 Detail
0.009 uterine corpus cancer This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pa... BeFree 25301678 Detail
0.009 uterine corpus cancer Targeted, massively parallel DNA sequencing and molecular inversion probe microa... BeFree 25588929 Detail
0.009 uterine corpus cancer The phosphoinositol-3 kinase (PI3K) pathway is frequently dysregulated in endome... BeFree 25624430 Detail
0.009 uterine corpus cancer We also report that nuclear localization of FOXO1 correlated with PTEN mutationa... BeFree 25698082 Detail
0.009 uterine corpus cancer NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activat... BeFree 26193427 Detail
0.120 Malformations of Cortical Development NA CTD_human Detail
<0.001 PTEN hamartoma tumor syndrome NA BeFree Detail
<0.001 Philadelphia chromosome-positive acute lymphoblastic leukemia NA BeFree Detail
0.006 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma In this review, we summarize the existing knowledge of the relevance of Notch1 a... BeFree,GAD 24819383 Detail
0.006 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma We also explored the molecular mechanism of FHL1C overexpression-induced apoptos... BeFree,GAD 24952875 Detail
0.006 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma High activation of the PI3K-AKT-mTOR pathway is characteristic for T-cell acute ... BeFree,GAD 25241901 Detail
0.002 Precursor Cell Lymphoblastic Leukemia Lymphoma NA BeFree Detail
<0.001 Congenital vascular anomaly Most individuals from Boston Children's Hospital who had isolated LM (16/17) or ... BeFree 25681199 Detail
<0.001 Congenital vascular anomaly PIK3CA-related overgrowth spectrum (PROS) include a group of disorders that affe... BeFree 25915946 Detail
0.001 Urothelial Carcinoma NA BeFree Detail
0.377 liver carcinoma This mode of action for calycopterin in our study provides strong support that i... BeFree,CLINVAR,CTD_human,UNIPROT 25060910 Detail
0.377 liver carcinoma The PI3K/Akt/Snail-dependent pathway may mediate the pro-invasive and pro-metast... BeFree,CLINVAR,CTD_human,UNIPROT 25070581 Detail
0.377 liver carcinoma The inhibition of PI3K/Akt activation abolished epithelial-mesenchymal transitio... BeFree,CLINVAR,CTD_human,UNIPROT 25087096 Detail
0.377 liver carcinoma Bioinformatic method was applied to predict the binding of miR-218 on HoxA10, an... BeFree,CLINVAR,CTD_human,UNIPROT 25120782 Detail
0.377 liver carcinoma In clinical HCC samples, high expression of both CXCR2 and CXCL5 showed a signif... BeFree,CLINVAR,CTD_human,UNIPROT 25462858 Detail
0.377 liver carcinoma AT-rich interactive domain 2 (ARID2), catenin (cadherin-associated protein), bet... BeFree,CLINVAR,CTD_human,UNIPROT 25701229 Detail
0.377 liver carcinoma The purpose of this study was to determine the impact of sorafenib on PI3K/AKT/m... BeFree,CLINVAR,CTD_human,UNIPROT 25778319 Detail
0.377 liver carcinoma HBx induced AFP receptor expressed to activate PI3K/AKT signal to promote expres... BeFree,CLINVAR,CTD_human,UNIPROT 25943101 Detail
0.377 liver carcinoma Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/m... BeFree,CLINVAR,CTD_human,UNIPROT 26055238 Detail
0.377 liver carcinoma Moreover, LIFR knockdown could activate phosphoinositide 3-kinase/V-akt Murine T... BeFree,CLINVAR,CTD_human,UNIPROT 26249360 Detail
<0.001 Oropharyngeal Carcinoma Reverse-phase protein array profiling of oropharyngeal cancer and significance o... BeFree 24599934 Detail
<0.001 Allergic rhinitis (disorder) NA BeFree Detail
0.120 Breast-ovarian cancer, familial, susceptibility to, 1 NA CTD_human Detail
<0.001 Hepatitis B and hepatitis C NA BeFree Detail
0.001 Macroencephaly Diagnostic descriptors associated with PIK3CA mutations include fibroadipose ove... BeFree 24782230 Detail
0.001 Macroencephaly Recently, somatic and germline variants in genes that are involved in the PI3K-A... BeFree 24939587 Detail
<0.001 Sessile Serrated Adenoma/Polyp NA BeFree Detail
<0.001 Kashin-Beck Disease Role of selenoprotein S (SEPS1) -105G>A polymorphisms and PI3K/Akt signaling pat... BeFree 25433273 Detail
0.361 Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi This PIK3CA-associated segmental overgrowth syndrome overlaps with CLOVES syndro... BeFree,CLINVAR,ORPHANET,UNIPROT 24665065 Detail
0.361 Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi We detected a mosaic disease-causing mutation in PIK3CA by sequencing of DNA ext... BeFree,CLINVAR,ORPHANET,UNIPROT 25044986 Detail
<0.001 Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma NA BeFree Detail
<0.001 Chronic ulcerative colitis NA BeFree Detail
0.124 Nasopharyngeal carcinoma Epigenetic inactivation of inositol polyphosphate 4-phosphatase B (INPP4B), a re... BeFree,CTD_human 25126743 Detail
0.124 Nasopharyngeal carcinoma The current study demonstrated that EphA2 mediates sensitivity to paclitaxel via... BeFree,CTD_human 25351620 Detail
<0.001 aggressive cancer NA BeFree Detail
<0.001 Fetal Alcohol Spectrum Disorders NA BeFree Detail
<0.001 Early-Stage Breast Carcinoma NA BeFree Detail
<0.001 Overgrowth syndrome Segmental overgrowth syndrome due to an activating PIK3CA mutation identified in... BeFree 24665065 Detail
<0.001 Overgrowth syndrome Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, are ... BeFree 25550458 Detail
<0.001 Stage II Colon Cancer AJCC v7 NA BeFree Detail
<0.001 Primary acquired melanosis The PI3K/AKT/mTOR (PAM) signaling pathway controls key cellular responses, such ... BeFree 25601471 Detail
<0.001 myelodysplastic syndrome NA BeFree Detail
<0.001 Progressive cGVHD NA BeFree Detail
0.004 Triple Negative Breast Neoplasms Different targeted therapies may be necessary for TNBC that involves activation ... BeFree 25009009 Detail
0.004 Triple Negative Breast Neoplasms PIK3CA mutations in androgen receptor-positive triple negative breast cancer con... BeFree 25103565 Detail
0.004 Triple Negative Breast Neoplasms Mutational profiles in triple-negative breast cancer defined by ultradeep multig... BeFree 25296970 Detail
0.004 Triple Negative Breast Neoplasms To determine the frequency of PIK3CA mutations in a Peruvian cohort with HER2-am... BeFree 25467032 Detail
0.004 Triple Negative Breast Neoplasms β-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in tripl... BeFree 25721419 Detail
0.003 Infection NA LHGDN Detail
<0.001 ESTROGEN RESISTANCE Activation of the phosphatidylinositol-3-kinase (PI3K) and/or mitogen-activated ... BeFree 24447434 Detail
<0.001 ESTROGEN RESISTANCE Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway has been... BeFree 25491778 Detail
<0.001 Experimental Organism Basal Cell Carcinoma NA BeFree Detail
<0.001 Abdominal Neoplasms NA BeFree Detail
<0.001 Congenital Abnormality Brain overgrowth in disorders of RTK-PI3K-AKT signaling: a mosaic of malformatio... BeFree 25432429 Detail
0.139 adenocarcinoma Patients with adenocarcinoma had fewer PIK3CA mutations (14%), and survived long... BeFree,CTD_human,GAD,LHGDN 25426553 Detail
0.139 adenocarcinoma PIK3CA-mutated NSCLC represents a clinically and genetically heterogeneous subgr... BeFree,CTD_human,GAD,LHGDN 25473901 Detail
0.005 papillary adenocarcinoma NA GAD Detail
0.003 adenoma NA BeFree,GAD Detail
<0.001 Primary myelofibrosis NA BeFree Detail
<0.001 Alcoholic Intoxication, Chronic NA BeFree Detail
0.003 Alzheimer's disease NA BeFree,GAD Detail
<0.001 arteriosclerosis NA BeFree Detail
0.002 rheumatoid arthritis Following stimulation with 10 nM insulin for 30 min, the stable overexpression o... BeFree 25760103 Detail
<0.001 asthma NA BeFree Detail
0.006 Astrocytoma NA BeFree,GAD,LHGDN Detail
<0.001 atherosclerosis NA BeFree Detail
<0.001 autistic disorder NA BeFree Detail
<0.001 Autoimmune Diseases NA BeFree Detail
0.002 Barrett esophagus NA GAD Detail
0.004 Malignant neoplasm of urinary bladder PIK3CA gene alterations in bladder cancer are frequent and associate with reduce... BeFree 24347284 Detail
0.004 Malignant neoplasm of urinary bladder Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential us... BeFree 24929024 Detail
0.004 Malignant neoplasm of urinary bladder Our findings suggest that miR-21 acts as a molecular switch to regulate aerobic ... BeFree 25266796 Detail
0.004 Malignant neoplasm of urinary bladder Taken together, EN2 may be a candidate oncogene in BC by activating the PI3K/Akt... BeFree 25812440 Detail
0.004 Bladder Neoplasm Here, we analyzed the presence of mutations in FGFR3 and PIK3CA genes and copy n... BeFree,LHGDN 24347284 Detail
0.004 Brain Neoplasms NA BeFree,GAD Detail
<0.001 Brenner Tumor NA BeFree Detail
<0.001 Burkitt lymphoma NA BeFree Detail
<0.001 Carcinoid Tumor NA BeFree Detail
0.011 Malignant tumor of colon Synergism of PI3K/Akt inhibition and Fas activation on colon cancer cell death. BeFree 25199763 Detail
0.011 Malignant tumor of colon Fifteen genes (DUSP2, INFGR1, IL6, IRF2, JAK2, MAP3K10, MMP1, NFkB1A, NOS2A, PIK... BeFree 25541970 Detail
0.011 Malignant tumor of colon Quinazoline based small molecule exerts potent tumour suppressive properties by ... BeFree 25554016 Detail
0.011 Malignant tumor of colon PIK3CA mutations predict recurrence in localized microsatellite stable colon can... BeFree 25641861 Detail
0.011 Malignant tumor of colon In the present study, the expression status of miR-218 and the role of the phosp... BeFree 25760926 Detail
0.011 Malignant tumor of colon This study aims to characterize colon cancer with regard to KRAS, BRAF, and PIK3... BeFree 25884297 Detail
0.011 Malignant tumor of colon Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway gene... BeFree 25889965 Detail
0.011 Malignant tumor of colon Here, we detected its effects on DLD-1 and SW480 (two human colon cancer cell li... BeFree 26225471 Detail
0.009 Malignant neoplasm of endometrium PIK3CA mutations are commonly found in endometrial cancers. BeFree 25078343 Detail
0.009 Malignant neoplasm of endometrium The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal tra... BeFree 25141911 Detail
0.009 Malignant neoplasm of endometrium This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pa... BeFree 25301678 Detail
0.009 Malignant neoplasm of endometrium Targeted, massively parallel DNA sequencing and molecular inversion probe microa... BeFree 25588929 Detail
0.009 Malignant neoplasm of endometrium The phosphoinositol-3 kinase (PI3K) pathway is frequently dysregulated in endome... BeFree 25624430 Detail
0.009 Malignant neoplasm of endometrium We also report that nuclear localization of FOXO1 correlated with PTEN mutationa... BeFree 25698082 Detail
0.009 Malignant neoplasm of endometrium NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activat... BeFree 26193427 Detail
0.004 Rectal Carcinoma The phosphatidylinositol 3-kinase (PI3K), MAP kinase (MAPK), and related pathway... BeFree,GAD 24700299 Detail
0.004 Rectal Carcinoma Using a database of 735 colon and rectal cancers in the Nurse's Health Study and... BeFree,GAD 25023548 Detail
0.007 Malignant neoplasm of thyroid NA BeFree Detail
0.002 Noninfiltrating Intraductal Carcinoma PI3K pathway activation in high-grade ductal carcinoma in situ--implications for... BeFree 24634376 Detail
<0.001 Merkel cell carcinoma PIK3CA mutations were observed more frequently in MCPyV-positive MCCs (6/36 [17%... BeFree 25466966 Detail
0.003 mucinous adenocarcinoma NA BeFree,GAD Detail
0.137 Non-small cell lung carcinoma Increased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in... BeFree,CLINVAR 24736592 Detail
0.137 Non-small cell lung carcinoma In conclusion, the positive feedback loop between NOX4 and PI3K/Akt signaling co... BeFree,CLINVAR 24946933 Detail
0.137 Non-small cell lung carcinoma PIK3CA mutations in non-small cell lung cancer (NSCLC): genetic heterogeneity, p... BeFree,CLINVAR 25473901 Detail
0.137 Non-small cell lung carcinoma We have recently shown that Semaphorin 4B (SEMA4B) inhibits the invasion of non-... BeFree,CLINVAR 25746385 Detail
0.137 Non-small cell lung carcinoma ILT4 drives B7-H3 expression via PI3K/AKT/mTOR signalling and ILT4/B7-H3 co-expr... BeFree,CLINVAR 26149216 Detail
0.005 Carcinoma, Papillary NA BeFree,GAD Detail
0.128 renal cell carcinoma Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-indu... BeFree,CTD_human,LHGDN 24743574 Detail
0.128 renal cell carcinoma We genotyped 70 genes involved in the pathogenesis of renal-cell carcinoma (incl... BeFree,CTD_human,LHGDN 24767687 Detail
0.128 renal cell carcinoma The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway has been ide... BeFree,CTD_human,LHGDN 25757764 Detail
Annotation

Annotations

DescrptionSourceLinks
An Italian study of 163 malignant breast tumors assessed the association between PIK3CA mutations an... CIViC Evidence Detail
An Italian study of 163 malignant breast tumors assessed the association between PIK3CA mutations an... CIViC Evidence Detail
Taken together, our findings indicate that ghrelin can activate Snail function via the GHS-R-PI3K-Ak... DisGeNET Detail
Importantly, the level of miR-508 correlates with poor survival and activated PI3K/Akt signalling in... DisGeNET Detail
Patients with adenocarcinoma had fewer PIK3CA mutations (14%), and survived longer (median, 14.2 mon... DisGeNET Detail
PIK3CA-mutated NSCLC represents a clinically and genetically heterogeneous subgroup in adenocarcinom... DisGeNET Detail
Phosphoinositide-3-kinase (PI3K)-α inhibitors have shown clinical activity in squamous cell carcinom... DisGeNET Detail
Moreover, blocking the whole PI3K-AKT-mTOR pathway with the PI3K/mTOR dual inhibitor BEZ235 also sho... DisGeNET Detail
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Taken together, our data suggest that anti-VEGFa treatment in cervical cancer may inhibit both tumor... DisGeNET Detail
CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer. DisGeNET Detail
Peroxisome proliferator-activated receptor-gamma agonist 4-O-methylhonokiol induces apoptosis by tri... DisGeNET Detail
The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein is principally involved i... DisGeNET Detail
Butein suppresses cervical cancer growth through the PI3K/AKT/mTOR pathway. DisGeNET Detail
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In cells infected with the closely related chikungunya virus (CHIKV), the PI3K-Akt-mTOR pathway was ... DisGeNET Detail
Stimulation of chondrosarcoma with CCL5 augmented PI3K and Akt phosphorylation, while PI3K and Akt i... DisGeNET Detail
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In acute myeloid leukemia (AML), several signaling pathways such as the phosphatidylinositol-3-kinas... DisGeNET Detail
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bFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reper... DisGeNET Detail
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Effects of D-Pinitol on Insulin Resistance through the PI3K/Akt Signaling Pathway in Type 2 Diabetes... DisGeNET Detail
Podocyte-specific genetic ablation of XBP1 or inducible expression of ATF6 in mice aggravates DN. sX... DisGeNET Detail
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ARID1A and PIK3CA mutations appeared consistently in concurrent endometriosis when present in the pr... DisGeNET Detail
Distinct β-catenin and PIK3CA mutation profiles in endometriosis-associated ovarian endometrioid and... DisGeNET Detail
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Therefore, concomitant blockage of the ErbB2-PI3K pathway and the Hedgehog downstream mediator Gli-1... DisGeNET Detail
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Moreover, TRIM24 regulates the expression of DNA repair enzyme O(6)-methylguanine-DNA methyltransfer... DisGeNET Detail
ABT-263 (Navitoclax), an orally available small-molecule Bcl-2 inhibitor, and GDC-0941, a PI3K inhib... DisGeNET Detail
In this study, we used inhibitors to block specific signaling pathways, including JAK, PI3K/Akt, and... DisGeNET Detail
Application of a specific extracellular-related kinase 1/2 (ERK1/2) inhibitor, but not application o... DisGeNET Detail
However, due to the development of resistance mechanisms, kinase inhibition studies targeting the PI... DisGeNET Detail
The EGFR and PI3K/mTORC1/2 pathways are frequently altered in glioblastoma (GBM), but pharmacologic ... DisGeNET Detail
The activation of PI3K/Akt1 signaling pathway is involved in the proliferation of glioblastoma; howe... DisGeNET Detail
Further analyses revealed that Cyr61 seemed to activate PI3K/Akt/mTor signaling pathway to increase ... DisGeNET Detail
We previously reported that decreased miR-218 expression in GBM directly promotes RTK activity by in... DisGeNET Detail
TRIM24 promotes glioma progression and enhances chemoresistance through activation of the PI3K/Akt s... DisGeNET Detail
These results suggest that Liq treatment enhances glioma cell susceptibility to TMZ by inhibiting th... DisGeNET Detail
Several studies have attempted to investigate the effects of combining the inhibition of both PI3K a... DisGeNET Detail
The loss of MAGI3 expression in glioma may enhance the proliferation of glioma cells via downregulat... DisGeNET Detail
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ECCCs had SCA-like features with rare expression of estrogen receptor/progesterone receptor (18.8%/6... DisGeNET Detail
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This article highlights recent progress in characterizing the molecular mechanisms of PI3K isoform-s... DisGeNET Detail
This novel mechanism of Dlg1 subversion by adenovirus to dysregulate PI3K could be used by other pat... DisGeNET Detail
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In this study, we examined the effect of Ginsenoside Rb1 (GRb1) on ischemia/reperfusion-induced auto... DisGeNET Detail
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Most individuals from Boston Children's Hospital who had isolated LM (16/17) or LM as part of a synd... DisGeNET Detail
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In the present study, we have shown for the first time that HBA decreased the expression of phosphot... DisGeNET Detail
The PI3K/Akt signaling pathway is constitutively activated in various leukemias. DisGeNET Detail
Altogether, these results underline the key role of PI3K/AKT pathway in the generation of the CLL pr... DisGeNET Detail
The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signa... DisGeNET Detail
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Importantly, emodin was demonstrated as a new inhibitor of PI3K/Akt in AML cells, even in primary AM... DisGeNET Detail
Inhibiting rescue pathways could improve the therapeutic efficacy of PI3K-targeted therapies in AML. DisGeNET Detail
In the primary AML sample, we investigated the cell responses to ex vivo stimulation with stem cell ... DisGeNET Detail
The Ras/Raf/MAPK and PI3K/Akt/mTOR pathways are key signaling cascades involved in the regulation of... DisGeNET Detail
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The fusion gene bcr-abl develops chronic myeloid leukemia (CML), and stimulates PI3K/Akt/mTOR signal... DisGeNET Detail
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HBx induced AFP receptor expressed to activate PI3K/AKT signal to promote expression of Src in liver... DisGeNET Detail
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To clarify this point, biopsy tissue samples from 38 human FL cases were investigated for PIK3CA som... DisGeNET Detail
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The AKT/mTOR pathway was activated by mutations of PIK3CA and PTPN11 in 4 GCs. DisGeNET Detail
In conclusion, knockdown of the c‑Met gene promoted gastric cancer cell apoptosis and inhibited down... DisGeNET Detail
Mechanically, PTP1B promotes gastric cancer cell proliferation, survival and invasiveness through mo... DisGeNET Detail
Therefore, our studies reveal for the first time that inhibition of the PI3K-Akt pathway is involved... DisGeNET Detail
Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-κB signaling pa... DisGeNET Detail
Occurrence of low frequency PIK3CA and AKT2 mutations in gastric cancer. DisGeNET Detail
Identification of KRAS and PIK3CA but not BRAF mutations in patients with gastric cancer. DisGeNET Detail
Everolimus monotherapy was satisfactory in a patient with refractory metastatic GC harboring PIK3CA ... DisGeNET Detail
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Targeting the PI3K/AKT/mTOR signaling pathway in medulloblastoma. DisGeNET Detail
The Phosphoinositide 3-Kinase p110α Isoform Regulates Leukemia Inhibitory Factor Receptor Expression... DisGeNET Detail
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Recent attention has focused on the role of phosphatidylinositol 3-kinase (PI3K) in both immune and ... DisGeNET Detail
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Cancers like multiple myeloma (MM), which display elevated activity in key translation regulatory no... DisGeNET Detail
Furthermore, our results demonstrated that the enforced expression of miR-145 in H929 cells profound... DisGeNET Detail
Previously we showed that tetraspanin overexpression in MM cell lines attenuated mTOR and PI3K casca... DisGeNET Detail
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In situ assessment of PI3K and PTEN alterations in mycosis fungoides: correlation with clinicopathol... DisGeNET Detail
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Herein, we will review the clinically relevant inhibitors of the PI3K pathway that have been evaluat... DisGeNET Detail
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Mechanistically, knockdown of FAP inactivated PTEN/PI3K/AKT and Ras-ERK and its downstream signaling... DisGeNET Detail
IL-7 splicing variant IL-7δ5 induces EMT and metastasis of human breast cancer cell lines MCF-7 and ... DisGeNET Detail
Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3... DisGeNET Detail
However, the mechanisms and specific functions of PI3K isoforms in tumor invasion and metastasis are... DisGeNET Detail
Mutations of KRAS and PIK3CA as independent predictors of distant metastases in colorectal cancer. DisGeNET Detail
NOX4 promotes non-small cell lung cancer cell proliferation and metastasis through positive feedback... DisGeNET Detail
Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer... DisGeNET Detail
Yet, little is known concerning the role of the PI3K/Akt/Snail-dependent pathway in sorafenib‑induce... DisGeNET Detail
First-in-human study of CH5132799, an oral class I PI3K inhibitor, studying toxicity, pharmacokineti... DisGeNET Detail
Overexpression of ribonuclease inhibitor defines good prognosis and suppresses proliferation and met... DisGeNET Detail
These data indicate that the capacity of retinol to inhibit PI3K activity confers its ability to dec... DisGeNET Detail
These findings suggest that CEACAM6 enhances invasion and metastasis in GC by promoting EMT via the ... DisGeNET Detail
PIK3CA hotspot mutations are present at a relatively high frequency in CTCs and their presence is as... DisGeNET Detail
These findings indicated that MALAT1 might suppress the tumor growth and metastasis via PI3K/AKT sig... DisGeNET Detail
In conclusion, this study suggested that EMT process can be triggered by the BMP2/BMPR axis in gastr... DisGeNET Detail
The EGFR/PI3K/PTEN/Akt/mTORC pathway plays prominent roles in malignant transformation, prevention o... DisGeNET Detail
We sought to evaluate the impact of RAS and PIK3CA mutations on cumulative incidence of metastasis t... DisGeNET Detail
SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallblad... DisGeNET Detail
KRAS, BRAF and PIK3CA mutations are highly concordant between primary tumors and corresponding metas... DisGeNET Detail
The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway plays a cr... DisGeNET Detail
Together, these results demonstrate that HGF/c-met can activate PI3K/Akt and downstream NF-κB signal... DisGeNET Detail
Mechanistic studies further revealed that VAV3 overexpression could dysregulate the expression of ce... DisGeNET Detail
Prognostic value of PIK3CA mutation status, PTEN and androgen receptor expression for metastasis-fre... DisGeNET Detail
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We suggest that Nutlin-3, possibly in combination with FAK or PI3K inhibitors, can be employed as a ... DisGeNET Detail
Using the Snapshot assay, mutation statuses were detected for EGFR, Kirsten rate sarcoma viral oncog... DisGeNET Detail
Moreover, inhibitors of PI3K/mTOR and GLI signaling reduced neuroblastoma cell growth, but no additi... DisGeNET Detail
Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib i... DisGeNET Detail
We previously demonstrated that PI3K Class IIβ (PI3KC2β) and its regulator intersectin 1 (ITSN1) are... DisGeNET Detail
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This integrated view of PI3K functions may ultimately help to develop new therapeutic interventions ... DisGeNET Detail
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Knockdown of CXCR7 suppressed proliferation and invasion of OS cells through decreased expression of... DisGeNET Detail
The present results indicated that LY294002 inhibits the malignant phenotype of OS cells via modulat... DisGeNET Detail
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteos... DisGeNET Detail
In conclusion, icariin possesses a reversal effect on multidrug resistance in MG-63/DOX cells throug... DisGeNET Detail
Re-expression of ARHI in ovarian cancer cells blocks signaling through the PI3K and Ras/MAP pathways... DisGeNET Detail
MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the P... DisGeNET Detail
Inhibiting the PI3K/AKT pathway may be a useful treatment for ovarian carcinoma. DisGeNET Detail
Moreover, LY294002, a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinases... DisGeNET Detail
Gene mutation analysis showed that the cells belonged to the type II ovarian cancer pathway with mut... DisGeNET Detail
The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer. DisGeNET Detail
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In type 2 diabetes, obesity and PCOS, there is, although with some variation from study to study, de... DisGeNET Detail
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PTEN inactivation by mutation or allelic loss also occurs in CRCs. miR‑135b was reported to be upreg... DisGeNET Detail
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Genome-wide analyses have identified four major signaling nodes that are most frequently altered in ... DisGeNET Detail
PIK3R3, an isoform of class IA phosphoinositide 3-kinase (PI3K), specifically interacts with cell pr... DisGeNET Detail
In the present study, we searched for combination therapies with the dual PI3K/mTOR inhibitor NVP-BE... DisGeNET Detail
Thus, combined GLI1/2 and PI3K/mTOR inhibition represents a promising novel approach for synergistic... DisGeNET Detail
The aim of our study was to investigate whether common polymorphisms in the genes regulating the ear... DisGeNET Detail
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These data are the first to demonstrate that the inflammatory response induced by IL-1β promotes sei... DisGeNET Detail
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We have already shown that AKT is activated in skin lesions in Mycosis Fungoides (MF) and we herein ... DisGeNET Detail
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In conclusion, IL-8 stimulates VEGF production in hBM-MSCs in part via the PI3K/Akt and MAPK/ERK sig... DisGeNET Detail
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In addition, the phosphoinositide-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway w... DisGeNET Detail
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The phosphatidylinositol-3-kinase (PI3K) and Akt pathway is activated in host immune cells upon vira... DisGeNET Detail
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Many alterations directly or indirectly lead to activation of survival signaling pathways and expres... DisGeNET Detail
The oncogenic PI3K/serine-threonine kinase (PI3K/AKT) pathway is a downstream pathway of B-cell rece... DisGeNET Detail
Inhibition of the PI3K/Akt/mTOR signaling pathway in diffuse large B-cell lymphoma: current knowledg... DisGeNET Detail
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We suggest that targeting the PI3K/AKT pathway may be a promising therapeutic strategy for PTCL. DisGeNET Detail
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Prognostic significance of PIK3CA and SOX2 in Asian patients with lung squamous cell carcinoma. DisGeNET Detail
This study reveals a critical role for the PTEN/PI3K pathway in both SCLC and lung adenocarcinoma an... DisGeNET Detail
The PI3K/AKT/mTOR pathway is distinguishable in SCLC genomic alterations. DisGeNET Detail
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bFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reper... DisGeNET Detail
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These data identify RIT1 as a driver oncogene in a specific subset of lung adenocarcinomas and sugge... DisGeNET Detail
This study reveals a critical role for the PTEN/PI3K pathway in both SCLC and lung adenocarcinoma an... DisGeNET Detail
Data were reviewed for patients with advanced lung adenocarcinomas enrolled in the Lung Cancer Mutat... DisGeNET Detail
ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas. DisGeNET Detail
Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis... DisGeNET Detail
Therefore, concomitant blockage of the ErbB2-PI3K pathway and the Hedgehog downstream mediator Gli-1... DisGeNET Detail
Immunohistochemical and molecular analysis of PI3K/AKT/mTOR pathway in esophageal carcinoma. DisGeNET Detail
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Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations i... DisGeNET Detail
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We found that activation of the PI3K/Akt pathway was involved in the oncogenic functions of SPOCK1 i... DisGeNET Detail
Thus, Pten and Pik3ca have distinct consequences on the activation of the phosphatidylinositol 3-kin... DisGeNET Detail
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The patient was treated with the PI(3)Kα inhibitor BYL719, which achieved a lasting clinical respons... DisGeNET Detail
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Most individuals from Boston Children's Hospital who had isolated LM (16/17) or LM as part of a synd... DisGeNET Detail
PIK3CA-related overgrowth spectrum (PROS) include a group of disorders that affect only the terminal... DisGeNET Detail
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We propose the simultaneous activation of PLC-PKC-MEK1/2-ERK1/2 and PI3K pathways as the main mechan... DisGeNET Detail
These findings uncover a mechanism for constitutive PI3K/Akt activation in ESCC, and support a funct... DisGeNET Detail
Our data showed that the PTEN/PI3K pathway was active in human ESCC tissues in vivo, particularly in... DisGeNET Detail
The PI3K/AKT signal transduction pathway has distinct functional roles in tumor progression. DisGeNET Detail
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FGFR3, AKT1, and PIK3CA mutations are all reported for the first time in GCT. DisGeNET Detail
In addition to the commonly known AP-1 activators Mitogen-Activated Protein Kinases (MAPKs), there a... DisGeNET Detail
Anticancer effect of calycopterin via PI3K/Akt and MAPK signaling pathways, ROS-mediated pathway and... DisGeNET Detail
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Compared with ovarian clear cell carcinomas, endometrial clear cell carcinomas showed older mean pat... DisGeNET Detail
A patient with PIK3CA-mutated clear cell carcinoma of the ovary achieved a partial response by GCIG ... DisGeNET Detail
Crosstalk between PI3K and Ras pathways via protein phosphatase 2A in human ovarian clear cell carci... DisGeNET Detail
Distinct β-catenin and PIK3CA mutation profiles in endometriosis-associated ovarian endometrioid and... DisGeNET Detail
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ECCCs had SCA-like features with rare expression of estrogen receptor/progesterone receptor (18.8%/6... DisGeNET Detail
Preclinical investigations have suggested that the PI3K/AKT/mTOR pathway is frequently activated in ... DisGeNET Detail
The efficacy of both PI3K and MEK inhibitors was evaluated in a model of endometrioid carcinoma harb... DisGeNET Detail
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PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu over... DisGeNET Detail
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Importantly, PIK3CA was altered in all MIC/CSCCs by either mutation or amplification, but not in CIN... DisGeNET Detail
We studied a novel biomarker of human papillomavirus (HPV) life-cycle completion (panHPVE4), in comb... DisGeNET Detail
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Neuroendocrine cancer cell lines are used to investigate therapeutic targets in neuroendocrine tumor... DisGeNET Detail
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Diagnostic descriptors associated with PIK3CA mutations include fibroadipose overgrowth (FAO), Hemih... DisGeNET Detail
Recently, somatic and germline variants in genes that are involved in the PI3K-AKT pathway (AKT3, PI... DisGeNET Detail
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We found that activation of the PI3K/Akt pathway was involved in the oncogenic functions of SPOCK1 i... DisGeNET Detail
Further analysis showed that Cyr61 seemed to activate phosphatidylinositol 3-kinase (PI3K) but not e... DisGeNET Detail
Recent data identify 3-phosphoinositide-dependent protein kinase 1 as a key tumour-initiating event ... DisGeNET Detail
Activation of phosphoinositide-3 kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway play... DisGeNET Detail
Taken together, these data indicate that inhibition of MEK and PI3K alone or in combination with che... DisGeNET Detail
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microRNA-218 increase the sensitivity of gastrointestinal stromal tumor to imatinib through PI3K/AKT... DisGeNET Detail
We tested the in vivo efficacy of three PI3K inhibitors (PI3Ki) in patient-derived GIST xenograft mo... DisGeNET Detail
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PI3K/Akt/mTOR: A promising therapeutic target for non-medullary thyroid carcinoma. DisGeNET Detail
Cribriform-morular variant of papillary thyroid carcinoma: a study of 3 cases featuring the PIK3CA m... DisGeNET Detail
Lung cancer TCGA data validated these findings and unveiled overlap of FGFR1 mRNA positivity with KR... DisGeNET Detail
RNA interference-mediated knockdown of RhoGDI2 induces the migration and invasion of human lung canc... DisGeNET Detail
Data were reviewed for patients with advanced lung adenocarcinomas enrolled in the Lung Cancer Mutat... DisGeNET Detail
However, PIK3CA mutated lung cancer frequently develops in patients with prior malignancies. DisGeNET Detail
Common molecular drivers of lung cancer are mutations in receptor tyrosine kinases (RTKs) leading to... DisGeNET Detail
When the chimeric ubiquitin ligases were introduced into lung cancer SPC-A1 cells, they effectively ... DisGeNET Detail
The altered PI3K/mTOR pathway is implicated in lung cancer, but mTOR inhibitors have failed to demon... DisGeNET Detail
It was found that AKT1 and PI3K/p85 expression was upregulated in LCSCs compared with that in the pr... DisGeNET Detail
Hepatocyte growth factor (HGF) induces resistance to reversible and irreversible epidermal growth fa... DisGeNET Detail
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Genome-wide analyses have identified four major signaling nodes that are most frequently altered in ... DisGeNET Detail
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Here we studied tumour genomic evolution in a patient (index patient) with metastatic breast cancer ... DisGeNET Detail
The purpose of the study was to investigate the heterogeneity of PIK3CA mutational status within sin... DisGeNET Detail
Here, resistance to a class I PI3K inhibitor in a model of metastatic breast cancer driven by PI3K a... DisGeNET Detail
Successful control of heavily pretreated metastatic gastric cancer with the mTOR inhibitor everolimu... DisGeNET Detail
We analyzed the outcomes of patients with metastatic or recurrent cervical carcinomas who had a test... DisGeNET Detail
Molecular aberrations affecting the PI3K pathway may play a role in the progression from high-grade ... DisGeNET Detail
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PIK3CA mutations in small bowel adenocarcinoma. DisGeNET Detail
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Activation of the PI3K/AKT signal pathway is a known driving force for the progression to castration... DisGeNET Detail
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Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in met... DisGeNET Detail
Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations i... DisGeNET Detail
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Disruption in the E-cadherin complex is the hallmark of lobular lesions, but other signaling molecul... DisGeNET Detail
Our studies indicate that CK2-mediated PTEN posttranslational inactivation, associated with PI3K/Akt... DisGeNET Detail
ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: iden... DisGeNET Detail
In patients with squamous cell carcinoma of the cervix, the presence of PIK3CA mutations was associa... DisGeNET Detail
Genetic alterations of PIK3CA and tumor response in patients with locally advanced cervical squamous... DisGeNET Detail
Increased activity of PI3K/AKT/PMS2 could play a role in SETD2 mutated ccRCC. DisGeNET Detail
First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-k... DisGeNET Detail
BYL719, which selectively inhibits the alpha isoform of the phosphatidylinositol 3-kinase (PI3K) cat... DisGeNET Detail
Phase I combination of pazopanib and everolimus in PIK3CA mutation positive/PTEN loss patients with ... DisGeNET Detail
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PIK3CA mutations are more common in HPV(+) OPSCC and are associated with activation of mTOR, but not... DisGeNET Detail
Molecular alterations of PIK3CA in uterine carcinosarcoma, clear cell, and serous tumors. DisGeNET Detail
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Novel somatic mutations were identified in four out of 18 patients with advanced ES and two of 10 pa... DisGeNET Detail
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Taken together, our data suggest that anti-VEGFa treatment in cervical cancer may inhibit both tumor... DisGeNET Detail
CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer. DisGeNET Detail
Peroxisome proliferator-activated receptor-gamma agonist 4-O-methylhonokiol induces apoptosis by tri... DisGeNET Detail
The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein is principally involved i... DisGeNET Detail
Butein suppresses cervical cancer growth through the PI3K/AKT/mTOR pathway. DisGeNET Detail
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Unlike Proteus syndrome, 31/35 (89%) patients with PIK3CA mutations had congenital overgrowth, and i... DisGeNET Detail
Diagnostic descriptors associated with PIK3CA mutations include fibroadipose overgrowth (FAO), Hemih... DisGeNET Detail
PIK3CA-related overgrowth spectrum (PROS) include a group of disorders that affect only the terminal... DisGeNET Detail
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Disruption in the E-cadherin complex is the hallmark of lobular lesions, but other signaling molecul... DisGeNET Detail
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In this study, the inhibitory effect of KYNA on activation of phosphoinositide 3-kinase/Akt (PI3K/Ak... DisGeNET Detail
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Historically, the clinical diagnoses in patients with PIK3CA activating mutations have included Fibr... DisGeNET Detail
PIK3CA-related overgrowth spectrum (PROS) include a group of disorders that affect only the terminal... DisGeNET Detail
The aim of this study was to investigate the role of miR-10b and its target genes ZEB1 and PIK3CA in... DisGeNET Detail
The data indicate that CIN genomes harbor unfixed mutations in addition to human papilloma virus inf... DisGeNET Detail
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Targeted, massively parallel DNA sequencing and molecular inversion probe microarray analysis reveal... DisGeNET Detail
PIK3CA mutations were observed in 11 (31.4%) of 35 OEMCas and 10 (35.7%) of 28 OCCCas. DisGeNET Detail
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Finally, we provide evidence that APOBEC activity is responsible for the generation of helical domai... DisGeNET Detail
Recent data identify 3-phosphoinositide-dependent protein kinase 1 as a key tumour-initiating event ... DisGeNET Detail
Activation of phosphoinositide-3 kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway play... DisGeNET Detail
Taken together, these data indicate that inhibition of MEK and PI3K alone or in combination with che... DisGeNET Detail
First-in-human study of CH5132799, an oral class I PI3K inhibitor, studying toxicity, pharmacokineti... DisGeNET Detail
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Juvenile myelomonocytic leukaemia-associated mutation in Cbl promotes resistance to apoptosis via th... DisGeNET Detail
We identified differential therapeutic vulnerabilities that emerge upon the loss of both PTEN and p5... DisGeNET Detail
A genome-wide RNAi screen identifies FOXO4 as a metastasis-suppressor through counteracting PI3K/AKT... DisGeNET Detail
The impact of miRNA on the canonical TGF-β Smad signalling pathway has been well investigated, hence... DisGeNET Detail
Restoration of PTEN expression or inhibition of PI3K action decreased cPLA₂α expression in PTEN-muta... DisGeNET Detail
Genome-wide analyses have identified four major signaling nodes that are most frequently altered in ... DisGeNET Detail
Targeting the PI3K/Akt pathway in prostate cancer: challenges and opportunities (review). DisGeNET Detail
The findings from this study suggest that the combination of dual PI3K/Akt/mTOR inhibitors (BEZ235 o... DisGeNET Detail
Co-targeting AR and PI3K/AKT signaling has been proposed to be a more effective therapeutic means fo... DisGeNET Detail
The Upregulation of PI3K/Akt and MAP Kinase Pathways is Associated with Resistance of Microtubule-Ta... DisGeNET Detail
Among the cancer networks and STNs we considered, it is found that there is a substantial amount of ... DisGeNET Detail
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Activating PIK3CA alleles and lymphangiogenic phenotype of lymphatic endothelial cells isolated from... DisGeNET Detail
Somatic PIK3CA mutations are the most common cause of isolated LMs and disorders in which LM is a co... DisGeNET Detail
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Importantly, PIK3CA was altered in all MIC/CSCCs by either mutation or amplification, but not in CIN... DisGeNET Detail
Endometrial cancers have been recently molecularly characterized; amplifications of human epidermal ... DisGeNET Detail
Evidence for different expression profiles for c-Met, EGFR, PTEN and the mTOR pathway in low and hig... DisGeNET Detail
PIK3CA mutations are commonly found in endometrial cancers. DisGeNET Detail
The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer s... DisGeNET Detail
This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pathway inhibitors in ... DisGeNET Detail
Targeted, massively parallel DNA sequencing and molecular inversion probe microarray analysis reveal... DisGeNET Detail
The phosphoinositol-3 kinase (PI3K) pathway is frequently dysregulated in endometrial cancer (EC). DisGeNET Detail
Activated mutant p110α causes endometrial carcinoma in the setting of biallelic Pten deletion. DisGeNET Detail
PIKing the type and pattern of PI3K pathway mutations in endometrioid endometrial carcinomas. DisGeNET Detail
NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt s... DisGeNET Detail
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However, the significance of PIK3CA gene alterations with respect to clinicopathological characteris... DisGeNET Detail
Other molecular alterations, like mTOR or PI3K pathway deregulation, or Matrilin 2 overexpression, m... DisGeNET Detail
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Therefore, concomitant blockage of the ErbB2-PI3K pathway and the Hedgehog downstream mediator Gli-1... DisGeNET Detail
The present review focuses on the most recent developments on the role of the PI3K/Akt pathway in th... DisGeNET Detail
Novel somatic mutations were identified in four out of 18 patients with advanced ES and two of 10 pa... DisGeNET Detail
We further show that expression of PTEN, a well-established, potent tumor suppressor, is lost in a s... DisGeNET Detail
We identified frequent PIK3CA mutations in patients with high-risk HNSCC confined predominantly to t... DisGeNET Detail
Y-box Binding Protein-1 Is Part of a Complex Molecular Network Linking ΔNp63α to the PI3K/akt Pathwa... DisGeNET Detail
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Divergence of P53, PTEN, PI3K, Akt and mTOR expression in tonsillar cancer. DisGeNET Detail
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Knockdown of CXCR7 suppressed proliferation and invasion of OS cells through decreased expression of... DisGeNET Detail
The present results indicated that LY294002 inhibits the malignant phenotype of OS cells via modulat... DisGeNET Detail
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteos... DisGeNET Detail
In conclusion, icariin possesses a reversal effect on multidrug resistance in MG-63/DOX cells throug... DisGeNET Detail
Costello syndrome (CS) is a rare genetic disorder caused, in the majority of cases, by germline miss... DisGeNET Detail
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We identified differential therapeutic vulnerabilities that emerge upon the loss of both PTEN and p5... DisGeNET Detail
A genome-wide RNAi screen identifies FOXO4 as a metastasis-suppressor through counteracting PI3K/AKT... DisGeNET Detail
The impact of miRNA on the canonical TGF-β Smad signalling pathway has been well investigated, hence... DisGeNET Detail
Restoration of PTEN expression or inhibition of PI3K action decreased cPLA₂α expression in PTEN-muta... DisGeNET Detail
Genome-wide analyses have identified four major signaling nodes that are most frequently altered in ... DisGeNET Detail
Targeting the PI3K/Akt pathway in prostate cancer: challenges and opportunities (review). DisGeNET Detail
The findings from this study suggest that the combination of dual PI3K/Akt/mTOR inhibitors (BEZ235 o... DisGeNET Detail
Co-targeting AR and PI3K/AKT signaling has been proposed to be a more effective therapeutic means fo... DisGeNET Detail
The Upregulation of PI3K/Akt and MAP Kinase Pathways is Associated with Resistance of Microtubule-Ta... DisGeNET Detail
Among the cancer networks and STNs we considered, it is found that there is a substantial amount of ... DisGeNET Detail
Inhibiting the PI3K/AKT pathway may be a useful treatment for ovarian carcinoma. DisGeNET Detail
In conclusion, the results of the present study demonstrated that PI3K/AKT and Rab25 significantly c... DisGeNET Detail
These findings revealed that miR‑338‑3p may act as a tumor suppressor that blocks the growth of huma... DisGeNET Detail
Therefore, the hyperactivity of PI3K/Akt pathway and elevated levels of p53R2 can give rise to highl... DisGeNET Detail
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Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor. DisGeNET Detail
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Lung cancer TCGA data validated these findings and unveiled overlap of FGFR1 mRNA positivity with KR... DisGeNET Detail
RNA interference-mediated knockdown of RhoGDI2 induces the migration and invasion of human lung canc... DisGeNET Detail
Data were reviewed for patients with advanced lung adenocarcinomas enrolled in the Lung Cancer Mutat... DisGeNET Detail
However, PIK3CA mutated lung cancer frequently develops in patients with prior malignancies. DisGeNET Detail
Common molecular drivers of lung cancer are mutations in receptor tyrosine kinases (RTKs) leading to... DisGeNET Detail
When the chimeric ubiquitin ligases were introduced into lung cancer SPC-A1 cells, they effectively ... DisGeNET Detail
The altered PI3K/mTOR pathway is implicated in lung cancer, but mTOR inhibitors have failed to demon... DisGeNET Detail
It was found that AKT1 and PI3K/p85 expression was upregulated in LCSCs compared with that in the pr... DisGeNET Detail
Hepatocyte growth factor (HGF) induces resistance to reversible and irreversible epidermal growth fa... DisGeNET Detail
Our data showed that the PTEN/PI3K pathway was active in human ESCC tissues in vivo, particularly in... DisGeNET Detail
The frequency of mutations in either KRAS or PIK3CA were significantly higher in patients without ly... DisGeNET Detail
NA DisGeNET Detail
Synergism of PI3K/Akt inhibition and Fas activation on colon cancer cell death. DisGeNET Detail
Fifteen genes (DUSP2, INFGR1, IL6, IRF2, JAK2, MAP3K10, MMP1, NFkB1A, NOS2A, PIK3CA, SEPX1, SMAD3, T... DisGeNET Detail
Quinazoline based small molecule exerts potent tumour suppressive properties by inhibiting PI3K/Akt/... DisGeNET Detail
PIK3CA mutations predict recurrence in localized microsatellite stable colon cancer. DisGeNET Detail
In the present study, the expression status of miR-218 and the role of the phosphoinositide 3-kinase... DisGeNET Detail
This study aims to characterize colon cancer with regard to KRAS, BRAF, and PIK3CA mutations, micros... DisGeNET Detail
Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT... DisGeNET Detail
Here, we detected its effects on DLD-1 and SW480 (two human colon cancer cell lines) and investigate... DisGeNET Detail
The AKT/mTOR pathway was activated by mutations of PIK3CA and PTPN11 in 4 GCs. DisGeNET Detail
These data suggest that EGF-induced activation of MMP7 and MMP13 in GC is through phosphatidylinosit... DisGeNET Detail
In conclusion, knockdown of the c‑Met gene promoted gastric cancer cell apoptosis and inhibited down... DisGeNET Detail
Mechanically, PTP1B promotes gastric cancer cell proliferation, survival and invasiveness through mo... DisGeNET Detail
Therefore, our studies reveal for the first time that inhibition of the PI3K-Akt pathway is involved... DisGeNET Detail
Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-κB signaling pa... DisGeNET Detail
Occurrence of low frequency PIK3CA and AKT2 mutations in gastric cancer. DisGeNET Detail
Identification of KRAS and PIK3CA but not BRAF mutations in patients with gastric cancer. DisGeNET Detail
Everolimus monotherapy was satisfactory in a patient with refractory metastatic GC harboring PIK3CA ... DisGeNET Detail
PIK3CA gene alterations in bladder cancer are frequent and associate with reduced recurrence in non-... DisGeNET Detail
Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential use in the treatment o... DisGeNET Detail
Our findings suggest that miR-21 acts as a molecular switch to regulate aerobic glycolysis in bladde... DisGeNET Detail
Taken together, EN2 may be a candidate oncogene in BC by activating the PI3K/Akt pathway and inhibit... DisGeNET Detail
This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pathway inhibitors in ... DisGeNET Detail
NA DisGeNET Detail
Using the Snapshot assay, mutation statuses were detected for EGFR, Kirsten rate sarcoma viral oncog... DisGeNET Detail
Moreover, inhibitors of PI3K/mTOR and GLI signaling reduced neuroblastoma cell growth, but no additi... DisGeNET Detail
Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib i... DisGeNET Detail
We previously demonstrated that PI3K Class IIβ (PI3KC2β) and its regulator intersectin 1 (ITSN1) are... DisGeNET Detail
NA DisGeNET Detail
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Targeted inhibition of the PI3K/mTOR and Hhpathways indicates a new avenue for BTC treatment with co... DisGeNET Detail
Divergence of P53, PTEN, PI3K, Akt and mTOR expression in tonsillar cancer. DisGeNET Detail
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MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma. DisGeNET Detail
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Inhibition of PI3K and Akt kinase prevented the phosphorylation of 4E-BP1, suggesting that PI3K sign... DisGeNET Detail
NA DisGeNET Detail
PI3K pathway activation in high-grade ductal carcinoma in situ--implications for progression to inva... DisGeNET Detail
NA DisGeNET Detail
Our model allowed us to test the contributions of oncogenes in the RTK/RAS/PI(3)K pathway, and their... DisGeNET Detail
These and their respective parent cell lines were tested for sensitivity to erlotinib, IGFIR inhibit... DisGeNET Detail
NA DisGeNET Detail
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The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colo... DisGeNET Detail
Although epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) cetuximab are used widely... DisGeNET Detail
Comparison of neuroendocrine differentiation and KRAS/NRAS/BRAF/PIK3CA/TP53 mutation status in prima... DisGeNET Detail
We performed a computerized search of the electronic medical record of our institution for mCRC case... DisGeNET Detail
A retrospective observational study of clinicopathological features of KRAS, NRAS, BRAF and PIK3CA m... DisGeNET Detail
NA DisGeNET Detail
In this study we performed multiplex targeted sequencing of 10 genes in the PI3K/AKT pathway on brai... DisGeNET Detail
NA DisGeNET Detail
Re-expression of ARHI in ovarian cancer cells blocks signaling through the PI3K and Ras/MAP pathways... DisGeNET Detail
MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the P... DisGeNET Detail
Moreover, LY294002, a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinases... DisGeNET Detail
Gene mutation analysis showed that the cells belonged to the type II ovarian cancer pathway with mut... DisGeNET Detail
The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer. DisGeNET Detail
NA DisGeNET Detail
We identified frequent PIK3CA mutations in patients with high-risk HNSCC confined predominantly to t... DisGeNET Detail
The purpose of this study was to determine whether single nucleotide polymorphisms (SNPs) in AKT1, A... DisGeNET Detail
A comprehensive evaluation of biomarkers predictive of response to PI3K inhibitors and of resistance... DisGeNET Detail
Emphasis is placed on the therapeutic implications of genes frequently altered in HNSCCs (i.e., TP53... DisGeNET Detail
Response of head and neck squamous cell carcinoma cells carrying PIK3CA mutations to selected target... DisGeNET Detail
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Herein, we will review the clinically relevant inhibitors of the PI3K pathway that have been evaluat... DisGeNET Detail
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Our results show that Sendai virus infection, which is recognized by RIG-I, led to IRF3 activation a... DisGeNET Detail
NA DisGeNET Detail
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Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in hum... DisGeNET Detail
Targeted PI3K/AKT/mTOR therapy for metastatic carcinomas of the cervix: A phase I clinical experienc... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
We validated the top ranking genes, i.e., PIK3CA and PIK3CB, by showing that their forced expression... DisGeNET Detail
Activating mutations of PIK3CA are the most frequent genomic alterations in estrogen receptor (ER)-p... DisGeNET Detail
Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity. DisGeNET Detail
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The tumor suppressor WIF1 was also found to be capable of suppressing tumor growth through the inhib... DisGeNET Detail
Increased CYP4Z2P- and CYP4Z1-3'UTR expression promotes tumor angiogenesis in breast cancer partly v... DisGeNET Detail
NA DisGeNET Detail
The combination of HER2 inhibitors with PI3K inhibition was studied in HER2-amplified xenograft mode... DisGeNET Detail
Using AR + TNBC cell line and xenograft models we evaluated the effectiveness of PI3K inhibitors, us... DisGeNET Detail
In addition, the phosphoinositide-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway w... DisGeNET Detail
We tested the in vivo efficacy of three PI3K inhibitors (PI3Ki) in patient-derived GIST xenograft mo... DisGeNET Detail
In this study, we investigated the mechanisms of AZD6244 alone or with BEZ235, an orally available p... DisGeNET Detail
NA DisGeNET Detail
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An enrichment of PIK3CA exon 20 mutations was observed in progesterone receptor- positive tumors. DisGeNET Detail
ECCCs had SCA-like features with rare expression of estrogen receptor/progesterone receptor (18.8%/6... DisGeNET Detail
Preclinical investigations have suggested that the PI3K/AKT/mTOR pathway is frequently activated in ... DisGeNET Detail
Here, using specific inhibitors, we found that the activation of EGFR signaling promoted GBM growth ... DisGeNET Detail
The phosphoinositide 3-kinase (PI3K)/Akt/PTEN signaling pathway is deregulated in GBM. DisGeNET Detail
NA DisGeNET Detail
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Important mechanisms we discuss include (1) improved DNA repair in normal, but not tumor cells; (2) ... DisGeNET Detail
Molecular alterations of PIK3CA in uterine carcinosarcoma, clear cell, and serous tumors. DisGeNET Detail
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Our findings warrant further investigation of the role of different types of PIK3CA mutations and th... DisGeNET Detail
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Diagnostic descriptors associated with PIK3CA mutations include fibroadipose overgrowth (FAO), Hemih... DisGeNET Detail
PIK3CA-related overgrowth spectrum (PROS) include a group of disorders that affect only the terminal... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Germline PTPN11 and somatic PIK3CA variant in a boy with megalencephaly-capillary malformation syndr... DisGeNET Detail
PIK3CA mutations are commonly found in endometrial cancers. DisGeNET Detail
The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer s... DisGeNET Detail
This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pathway inhibitors in ... DisGeNET Detail
Targeted, massively parallel DNA sequencing and molecular inversion probe microarray analysis reveal... DisGeNET Detail
The phosphoinositol-3 kinase (PI3K) pathway is frequently dysregulated in endometrial cancer (EC). DisGeNET Detail
We also report that nuclear localization of FOXO1 correlated with PTEN mutational status irrespectiv... DisGeNET Detail
NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt s... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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In this review, we summarize the existing knowledge of the relevance of Notch1 and PI3K/Akt/mTOR sig... DisGeNET Detail
We also explored the molecular mechanism of FHL1C overexpression-induced apoptosis, which suppressed... DisGeNET Detail
High activation of the PI3K-AKT-mTOR pathway is characteristic for T-cell acute lymphoblastic leukem... DisGeNET Detail
NA DisGeNET Detail
Most individuals from Boston Children's Hospital who had isolated LM (16/17) or LM as part of a synd... DisGeNET Detail
PIK3CA-related overgrowth spectrum (PROS) include a group of disorders that affect only the terminal... DisGeNET Detail
NA DisGeNET Detail
This mode of action for calycopterin in our study provides strong support that inhibition of PI3K/Ak... DisGeNET Detail
The PI3K/Akt/Snail-dependent pathway may mediate the pro-invasive and pro-metastatic effects of sora... DisGeNET Detail
The inhibition of PI3K/Akt activation abolished epithelial-mesenchymal transition (EMT) and invasion... DisGeNET Detail
Bioinformatic method was applied to predict the binding of miR-218 on HoxA10, and western blotting w... DisGeNET Detail
In clinical HCC samples, high expression of both CXCR2 and CXCL5 showed a significant correlation wi... DisGeNET Detail
AT-rich interactive domain 2 (ARID2), catenin (cadherin-associated protein), beta 1, 88kDa (β-cateni... DisGeNET Detail
The purpose of this study was to determine the impact of sorafenib on PI3K/AKT/mTOR signaling pathwa... DisGeNET Detail
HBx induced AFP receptor expressed to activate PI3K/AKT signal to promote expression of Src in liver... DisGeNET Detail
Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepat... DisGeNET Detail
Moreover, LIFR knockdown could activate phosphoinositide 3-kinase/V-akt Murine Thymoma Viral Oncogen... DisGeNET Detail
Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations i... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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Diagnostic descriptors associated with PIK3CA mutations include fibroadipose overgrowth (FAO), Hemih... DisGeNET Detail
Recently, somatic and germline variants in genes that are involved in the PI3K-AKT pathway (AKT3, PI... DisGeNET Detail
NA DisGeNET Detail
Role of selenoprotein S (SEPS1) -105G>A polymorphisms and PI3K/Akt signaling pathway in Kashin-Beck ... DisGeNET Detail
This PIK3CA-associated segmental overgrowth syndrome overlaps with CLOVES syndrome and fibroadipose ... DisGeNET Detail
We detected a mosaic disease-causing mutation in PIK3CA by sequencing of DNA extracted from cultured... DisGeNET Detail
NA DisGeNET Detail
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Epigenetic inactivation of inositol polyphosphate 4-phosphatase B (INPP4B), a regulator of PI3K/AKT ... DisGeNET Detail
The current study demonstrated that EphA2 mediates sensitivity to paclitaxel via the regulation of t... DisGeNET Detail
NA DisGeNET Detail
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Segmental overgrowth syndrome due to an activating PIK3CA mutation identified in affected muscle tis... DisGeNET Detail
Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, are among the most commo... DisGeNET Detail
NA DisGeNET Detail
The PI3K/AKT/mTOR (PAM) signaling pathway controls key cellular responses, such as cell growth and p... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Different targeted therapies may be necessary for TNBC that involves activation of PI3K/AKT or MAPK ... DisGeNET Detail
PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to t... DisGeNET Detail
Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show ... DisGeNET Detail
To determine the frequency of PIK3CA mutations in a Peruvian cohort with HER2-amplified and triple n... DisGeNET Detail
β-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast ca... DisGeNET Detail
NA DisGeNET Detail
Activation of the phosphatidylinositol-3-kinase (PI3K) and/or mitogen-activated protein kinase (MAPK... DisGeNET Detail
Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway has been implicated in anti-... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Brain overgrowth in disorders of RTK-PI3K-AKT signaling: a mosaic of malformations. DisGeNET Detail
Patients with adenocarcinoma had fewer PIK3CA mutations (14%), and survived longer (median, 14.2 mon... DisGeNET Detail
PIK3CA-mutated NSCLC represents a clinically and genetically heterogeneous subgroup in adenocarcinom... DisGeNET Detail
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Following stimulation with 10 nM insulin for 30 min, the stable overexpression of Arg972 IRS-1 and k... DisGeNET Detail
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NA DisGeNET Detail
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NA DisGeNET Detail
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NA DisGeNET Detail
PIK3CA gene alterations in bladder cancer are frequent and associate with reduced recurrence in non-... DisGeNET Detail
Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential use in the treatment o... DisGeNET Detail
Our findings suggest that miR-21 acts as a molecular switch to regulate aerobic glycolysis in bladde... DisGeNET Detail
Taken together, EN2 may be a candidate oncogene in BC by activating the PI3K/Akt pathway and inhibit... DisGeNET Detail
Here, we analyzed the presence of mutations in FGFR3 and PIK3CA genes and copy number alterations of... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Synergism of PI3K/Akt inhibition and Fas activation on colon cancer cell death. DisGeNET Detail
Fifteen genes (DUSP2, INFGR1, IL6, IRF2, JAK2, MAP3K10, MMP1, NFkB1A, NOS2A, PIK3CA, SEPX1, SMAD3, T... DisGeNET Detail
Quinazoline based small molecule exerts potent tumour suppressive properties by inhibiting PI3K/Akt/... DisGeNET Detail
PIK3CA mutations predict recurrence in localized microsatellite stable colon cancer. DisGeNET Detail
In the present study, the expression status of miR-218 and the role of the phosphoinositide 3-kinase... DisGeNET Detail
This study aims to characterize colon cancer with regard to KRAS, BRAF, and PIK3CA mutations, micros... DisGeNET Detail
Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT... DisGeNET Detail
Here, we detected its effects on DLD-1 and SW480 (two human colon cancer cell lines) and investigate... DisGeNET Detail
PIK3CA mutations are commonly found in endometrial cancers. DisGeNET Detail
The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer s... DisGeNET Detail
This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pathway inhibitors in ... DisGeNET Detail
Targeted, massively parallel DNA sequencing and molecular inversion probe microarray analysis reveal... DisGeNET Detail
The phosphoinositol-3 kinase (PI3K) pathway is frequently dysregulated in endometrial cancer (EC). DisGeNET Detail
We also report that nuclear localization of FOXO1 correlated with PTEN mutational status irrespectiv... DisGeNET Detail
NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt s... DisGeNET Detail
The phosphatidylinositol 3-kinase (PI3K), MAP kinase (MAPK), and related pathways are implicated in ... DisGeNET Detail
Using a database of 735 colon and rectal cancers in the Nurse's Health Study and the Health Professi... DisGeNET Detail
NA DisGeNET Detail
PI3K pathway activation in high-grade ductal carcinoma in situ--implications for progression to inva... DisGeNET Detail
PIK3CA mutations were observed more frequently in MCPyV-positive MCCs (6/36 [17%] vs 2/20 [10%]). DisGeNET Detail
NA DisGeNET Detail
Increased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung... DisGeNET Detail
In conclusion, the positive feedback loop between NOX4 and PI3K/Akt signaling contributes to NSCLC p... DisGeNET Detail
PIK3CA mutations in non-small cell lung cancer (NSCLC): genetic heterogeneity, prognostic impact and... DisGeNET Detail
We have recently shown that Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung canc... DisGeNET Detail
ILT4 drives B7-H3 expression via PI3K/AKT/mTOR signalling and ILT4/B7-H3 co-expression correlates wi... DisGeNET Detail
NA DisGeNET Detail
Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in hum... DisGeNET Detail
We genotyped 70 genes involved in the pathogenesis of renal-cell carcinoma (including the VHL/HIF/VE... DisGeNET Detail
The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway has been identified as an import... DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386584794 dbSNP
Genome
hg38
Position
chr3:179,148,357-179,240,093
Variant Type
snv
Variant (CIViC) (CIViC Variant)
EXON 20 MUTATION
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/2336
Variant (CIViC) (CIViC Variant)
EXON 9 MUTATION
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/2337
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