chr3:46370946:> Detail (hg38)

Information

Genome

Assembly Position
hg19 chr3:46,412,437-46,417,697 
hg38 chr3:46,370,946-46,376,206

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.011 Cardiovascular Diseases NA BeFree,GAD,LHGDN Detail
0.005 Carotid Artery Diseases NA GAD Detail
0.005 carotid stenosis NA BeFree,GAD Detail
0.005 celiac disease NA GAD Detail
<0.001 CNS disorder NA BeFree Detail
0.085 brain ischemia NA GAD,RGD Detail
0.003 Transient ischemic attack NA BeFree,GAD Detail
<0.001 Malignant tumor of cervix CCR5 expression is elevated in cervical cancer cells and is up-regulated by semi... BeFree 25103627 Detail
0.005 Chagas Cardiomyopathy NA BeFree,GAD Detail
0.007 Chlamydia Infections NA BeFree,GAD Detail
<0.001 Primary biliary cirrhosis NA BeFree Detail
0.009 Cholangitis, Sclerosing NA BeFree,GAD,LHGDN Detail
<0.001 chondrosarcoma NA BeFree Detail
<0.001 choriocarcinoma NA BeFree Detail
0.002 Chromosome Deletion NA GAD Detail
0.001 ulcerative colitis NA BeFree Detail
0.001 colorectal carcinoma We demonstrate that stronger secretion of CXCL10 (CXCR3 ligand) and CCL5 (CCR5 l... BeFree 25671296 Detail
0.003 Colorectal Neoplasms NA LHGDN Detail
0.003 coronary aneurysm NA BeFree,GAD Detail
0.006 Coronary Arteriosclerosis NA BeFree,GAD Detail
0.009 Coronary heart disease NA BeFree,GAD,LHGDN Detail
0.006 Crohn Disease NA BeFree,GAD Detail
0.002 Cross Infection NA GAD Detail
0.003 cryptosporidiosis NA BeFree,GAD Detail
<0.001 cystic fibrosis Here, we report generation of cystic fibrosis (CF) and Gaucher's disease (GD) hi... BeFree 25245091 Detail
0.003 Cytomegalovirus Infections Incidence and dynamics of active cytomegalovirus infection in allogeneic stem ce... BeFree,GAD 25132583 Detail
<0.001 Presenile dementia NA BeFree Detail
<0.001 Dengue Fever Dengue virus requires the CC-chemokine receptor CCR5 for replication and infecti... BeFree 25939314 Detail
0.120 Dermatitis, Atopic NA CTD_human Detail
<0.001 Diabetes The CCR5 59029G>A and ELMO1 (+9170 G>A) loci are more frequent, and the SLC12A3 ... BeFree 24433479 Detail
<0.001 diabetes mellitus The CCR5 59029G>A and ELMO1 (+9170 G>A) loci are more frequent, and the SLC12A3 ... BeFree 24433479 Detail
0.102 Diabetes Mellitus, Insulin-Dependent NA BeFree,GAD,RGD Detail
0.097 Diabetes Mellitus, Non-Insulin-Dependent Variations in CCR5, but not HFE, ELMO1, or SLC12A3, are associated with suscepti... BeFree,GAD,RGD 24433479 Detail
<0.001 Down syndrome A set of 17 differentially expressed genes, not located on chromosome 21 (HSA21)... BeFree 25222269 Detail
<0.001 Dry Eye Syndromes NA BeFree Detail
0.002 Embolism NA GAD Detail
0.004 encephalitis NA BeFree,LHGDN Detail
0.003 tick-borne encephalitis Independently of age, nonfunctional CCR5Δ32 mutation is a significant risk facto... BeFree,GAD 25226020 Detail
0.081 Experimental Autoimmune Encephalomyelitis NA BeFree,RGD Detail
<0.001 endometriosis NA BeFree Detail
0.002 erythema nodosum NA GAD Detail
0.080 Fever NA RGD Detail
<0.001 Gaucher disease Subsequent excision of the donor cassette was done by treating CCR5-modified CF ... BeFree 25245091 Detail
0.002 Female Genital Diseases NA GAD Detail
<0.001 Gingival Diseases NA BeFree Detail
<0.001 glioblastoma NA BeFree Detail
<0.001 Glioma NA BeFree Detail
0.131 IgA glomerulonephritis NA BeFree,CTD_human,GAD,LHGDN Detail
0.013 Graft-vs-Host Disease Several recent clinical trials were all based on previously reported findings fr... BeFree,GAD,LHGDN 25532439 Detail
<0.001 Graves Disease NA BeFree Detail
<0.001 Heart failure NA BeFree Detail
<0.001 congestive heart failure NA BeFree Detail
0.010 Hemophilia A NA BeFree,GAD Detail
0.017 hepatitis B We will provide a rigorous review of the Bayesian variable partition model and t... BeFree,GAD,LHGDN 25387976 Detail
0.159 hepatitis C NA BeFree,CTD_human,GAD,LHGDN Detail
0.001 Herpes Simplex Infections Enhanced HIV-1 replication was associated with increased CD4, CCR5, and CD38 tra... BeFree 24496317 Detail
0.003 Herpes zoster disease NA BeFree,GAD Detail
0.185 HIV Infections Coreceptor tropism was completely concordant in paired pre-treatment RNA and DNA... BeFree,GAD,LHGDN 24155059 Detail
0.185 HIV Infections HIV-1 uses the coreceptors CCR5 and/or CXCR4 for cell entry. BeFree,GAD,LHGDN 24205895 Detail
0.185 HIV Infections Enhanced HIV-1 replication was associated with increased CD4, CCR5, and CD38 tra... BeFree,GAD,LHGDN 24496317 Detail
0.185 HIV Infections The CX3CR1 A allele and lower genetic scores may restrict the switch of HIV-1 tr... BeFree,GAD,LHGDN 24750723 Detail
0.185 HIV Infections We investigated the impact of FGS on HIV target cell density and expression of t... BeFree,GAD,LHGDN 24896815 Detail
0.185 HIV Infections HIV-1 tropism dynamics and phylogenetic analysis from longitudinal ultra-deep se... BeFree,GAD,LHGDN 25032817 Detail
0.185 HIV Infections When pDC were depleted prior to HIV-1 infection, the induction of IFN-I and inte... BeFree,GAD,LHGDN 25077616 Detail
0.185 HIV Infections A 32-nucleotide deletion within the CCR5 reading frame is associated with decrea... BeFree,GAD,LHGDN 25172974 Detail
0.185 HIV Infections Treatment intensification with maraviroc (CCR5 antagonist) leads to declines in ... BeFree,GAD,LHGDN 25227930 Detail
0.185 HIV Infections The role of CCR5 in HIV infection led to the development of specific and potent ... BeFree,GAD,LHGDN 25256399 Detail
0.185 HIV Infections This high prevalence of X4 virus might compromise the use of CCR5 inhibitors, cu... BeFree,GAD,LHGDN 25265081 Detail
0.185 HIV Infections We illustrate our approach with an analysis of the effect of the CCR5Δ32 mutatio... BeFree,GAD,LHGDN 25270736 Detail
0.185 HIV Infections Furthermore, a mutated virus that is capable of using both CCR5 and CXCR4 as ent... BeFree,GAD,LHGDN 25330146 Detail
0.185 HIV Infections We will provide a rigorous review of the Bayesian variable partition model and t... BeFree,GAD,LHGDN 25387976 Detail
0.185 HIV Infections Replication competent recombinant viruses incorporating the HIV RNA+/Ab- as comp... BeFree,GAD,LHGDN 25430652 Detail
0.185 HIV Infections CCR5 gene disruption via lentiviral vectors expressing Cas9 and single guided RN... BeFree,GAD,LHGDN 25541967 Detail
0.185 HIV Infections Genotyping of CCR5 gene, CCR2b and SDF1 variants related to HIV-1 infection in G... BeFree,GAD,LHGDN 25592723 Detail
0.185 HIV Infections CCR5 is a main cc-chemokine co-receptor that facilitates HIV-1 entry to macropha... BeFree,GAD,LHGDN 25613565 Detail
0.185 HIV Infections A deletion of 32bp (CCR5Δ32) in the CCR5 gene seems to protect against HIV-1, S.... BeFree,GAD,LHGDN 25638273 Detail
0.185 HIV Infections Studies of individuals who were highly exposed but seronegative (HESN) for HIV i... BeFree,GAD,LHGDN 25703062 Detail
0.185 HIV Infections The PhenoSeq platform will inform the appropriate use of maraviroc and future CC... BeFree,GAD,LHGDN 25712827 Detail
0.185 HIV Infections Viremic control and viral coreceptor usage in two HIV-1-infected persons homozyg... BeFree,GAD,LHGDN 25730507 Detail
0.185 HIV Infections The MIP-1α, MIP-1β, and RANTES chemokines are natural ligands of CCR5 and are kn... BeFree,GAD,LHGDN 25740989 Detail
0.185 HIV Infections However, the causes of resistance to HIV-1 infection in cases other than those w... BeFree,GAD,LHGDN 25746435 Detail
0.185 HIV Infections Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorp... BeFree,GAD,LHGDN 25797607 Detail
0.185 HIV Infections Herpes simplex virus type 2-infected dendritic cells produce TNF-α, which enhanc... BeFree,GAD,LHGDN 25840914 Detail
0.185 HIV Infections Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 us... BeFree,GAD,LHGDN 25854553 Detail
0.185 HIV Infections Lentivector Knockdown of CCR5 in Hematopoietic Stem and Progenitor Cells Confers... BeFree,GAD,LHGDN 25903342 Detail
0.185 HIV Infections This study focuses on trafficking of CCR5, a GPCR chemokine receptor and the pri... BeFree,GAD,LHGDN 25923671 Detail
0.185 HIV Infections mRNA transfection of a novel TAL effector nuclease (TALEN) facilitates efficient... BeFree,GAD,LHGDN 25964300 Detail
0.185 HIV Infections The presence of CCR5-tropic variants in more than 85 % of our cohort of antiretr... BeFree,GAD,LHGDN 25966986 Detail
0.185 HIV Infections An impact of host genetic variation on HIV-1 susceptibility was identified early... BeFree,GAD,LHGDN 25988890 Detail
0.185 HIV Infections Over-expression of NHERF1 affects the ligands or HIV-1 gp120-induced CCR5 intern... BeFree,GAD,LHGDN 26018859 Detail
0.185 HIV Infections HIV-1 Nef, a key factor for viral pathogenesis, downregulates functionally impor... BeFree,GAD,LHGDN 26178998 Detail
0.185 HIV Infections The entry inhibitor drug maraviroc makes the cell coreceptor CCR5 unavailable fo... BeFree,GAD,LHGDN 26339063 Detail
<0.001 Hodgkin Disease NA BeFree Detail
0.080 Hyperalgesia NA RGD Detail
0.003 Hyperlipidemia NA BeFree,LHGDN Detail
0.002 Delayed Hypersensitivity NA GAD Detail
0.002 Immediate hypersensitivity NA GAD Detail
0.085 Hypertensive disease NA BeFree,GAD,RGD Detail
0.002 Hypertension, Portal NA GAD Detail
0.001 Immunologic Deficiency Syndromes We show that ex vivo SIV infection of lymphocytes from CCR5 wild-type SM is medi... BeFree 26109719 Detail
0.002 Female infertility NA GAD Detail
0.104 Inflammation NA GAD,RGD Detail
0.007 Inflammatory Bowel Diseases NA BeFree,GAD Detail
0.001 influenza The CCR5Δ32 allele was not found to be associated with the risk of H1N1pdm09 inf... BeFree 25100510 Detail
0.001 influenza CCR5 deficiency predisposes to fatal outcome in influenza virus infection. BeFree 25918237 Detail
0.002 ischemia NA GAD Detail
<0.001 arthropathy NA BeFree Detail
0.002 Kidney Diseases Variations in CCR5, but not HFE, ELMO1, or SLC12A3, are associated with suscepti... BeFree 24433479 Detail
0.096 Kidney Failure, Chronic NA BeFree,GAD,LHGDN,RGD Detail
<0.001 acute kidney tubular necrosis NA BeFree Detail
0.002 Laryngeal neoplasm NA GAD Detail
<0.001 leishmaniasis NA BeFree Detail
0.002 Leishmaniasis, Cutaneous NA GAD Detail
0.003 leukemia NA BeFree,LHGDN Detail
<0.001 Leukemia, Myelocytic, Acute NA BeFree Detail
0.002 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma NA GAD Detail
0.003 liver cirrhosis NA BeFree,GAD Detail
0.002 Biliary cirrhosis NA GAD Detail
0.004 Liver diseases NA BeFree,LHGDN Detail
0.002 Liver neoplasms NA GAD Detail
0.003 Lung diseases NA BeFree,LHGDN Detail
0.006 Chronic Obstructive Airway Disease NA BeFree,GAD,LHGDN Detail
0.004 Lupus Erythematosus, Systemic This meta-analysis demonstrates that the CCR5-Δ32 polymorphism is associated wit... BeFree,GAD 24599359 Detail
0.009 lupus nephritis Chemokine receptor 5 (CCR5) delta 32 polymorphism in lupus nephritis: a large ca... BeFree,GAD,LHGDN 24720467 Detail
0.003 lymphocytic choriomeningitis NA LHGDN Detail
0.003 lymphoma NA BeFree,GAD Detail
<0.001 Lymphoma, Follicular NA BeFree Detail
<0.001 malaria NA BeFree Detail
0.002 Animal Mammary Neoplasms NA GAD Detail
<0.001 measles NA BeFree Detail
0.005 melanoma NA GAD,LHGDN Detail
0.003 meningoencephalitis NA BeFree,GAD Detail
0.002 mitral valve stenosis NA BeFree Detail
<0.001 Mouth Neoplasms NA BeFree Detail
0.011 Mucocutaneous Lymph Node Syndrome However, the overall OR for the CCR5-Δ32 allele was significantly higher in Kawa... BeFree,GAD,LHGDN 24599359 Detail
0.003 multiple myeloma NA BeFree,LHGDN Detail
0.054 multiple sclerosis NA BeFree,GAD,LHGDN Detail
0.003 Mycobacterium avium-intracellulare Infection NA BeFree,GAD Detail
<0.001 Mycoses NA BeFree Detail
0.014 myocardial infarction NA BeFree,GAD,LHGDN Detail
0.080 Myocardial Reperfusion Injury NA RGD Detail
0.003 myositis NA BeFree,LHGDN Detail
0.002 Neoplasm Metastasis The data reviewed here includes basic and translational studies that support the... BeFree 25256399 Detail
0.002 Neoplasm Metastasis We demonstrate that stronger secretion of CXCL10 (CXCR3 ligand) and CCL5 (CCR5 l... BeFree 25671296 Detail
0.002 Neoplasm Recurrence, Local NA GAD Detail
0.120 nephritis NA CTD_human Detail
<0.001 Nephritis, Interstitial NA BeFree Detail
0.002 nephrotic syndrome NA GAD Detail
<0.001 nervous system disorder NA BeFree Detail
<0.001 neuroblastoma NA BeFree Detail
<0.001 obesity NA BeFree Detail
0.002 Occupational Diseases NA GAD Detail
<0.001 Opportunistic Infections NA BeFree Detail
0.003 optic neuritis NA LHGDN Detail
0.080 orchitis NA RGD Detail
<0.001 Degenerative polyarthritis NA BeFree Detail
<0.001 osteomyelitis The CCR5Δ32 could be associated with protection against osteomyelitis caused by ... BeFree 25638273 Detail
<0.001 osteosarcoma CCL5/CCR5 axis induces vascular endothelial growth factor-mediated tumor angioge... BeFree 25330803 Detail
<0.001 Pancreatic Neoplasm NA BeFree Detail
<0.001 Periodontal Diseases NA BeFree Detail
0.003 periodontitis NA BeFree,GAD Detail
0.005 plague NA GAD Detail
0.003 polymyalgia rheumatica NA BeFree,GAD Detail
0.002 Postoperative Complications NA GAD Detail
0.007 Pregnancy Complications, Infectious NA GAD Detail
0.005 Prostatic Neoplasms NA LHGDN Detail
<0.001 psoriasis NA BeFree Detail
<0.001 pulmonary edema NA BeFree Detail
0.001 kidney failure NA BeFree Detail
0.005 Respiratory Syncytial Virus Infections NA GAD Detail
<0.001 retinal detachment NA BeFree Detail
0.002 Rheumatism NA GAD Detail
0.009 sarcoidosis NA BeFree,GAD,LHGDN Detail
0.008 Sarcoidosis, Pulmonary NA BeFree,GAD,LHGDN Detail
0.005 schizophrenia NA BeFree,GAD,LHGDN Detail
<0.001 Sexually Transmitted Diseases NA BeFree Detail
0.002 Skin Neoplasms NA GAD Detail
<0.001 smallpox NA BeFree Detail
0.080 status epilepticus NA RGD Detail
0.005 Cerebrovascular accident NA BeFree,GAD Detail
0.005 Substance Abuse, Intravenous NA GAD Detail
0.003 Superinfection HIV-1 Nef downregulates the viral entry receptor CD4 as well as the coreceptors ... BeFree,LHGDN 26178998 Detail
<0.001 synovitis NA BeFree Detail
<0.001 syphilis NA BeFree Detail
<0.001 Giant Cell Arteritis NA BeFree Detail
<0.001 tetanus NA BeFree Detail
0.002 Thyroid Neoplasm NA GAD Detail
0.003 toxoplasmosis NA BeFree,GAD Detail
0.002 trachoma NA GAD Detail
0.009 Chagas disease Nine SNPs of CCR5 and CCR2 were typified to confirm the association previously f... BeFree,GAD,LHGDN 25312802 Detail
0.001 tuberculosis NA BeFree Detail
0.001 Tuberculosis, Pulmonary NA BeFree Detail
0.082 uveitis NA GAD,RGD Detail
0.080 anterior uveitis NA RGD Detail
<0.001 Vascular Diseases NA BeFree Detail
0.003 vasculitis NA BeFree,LHGDN Detail
0.010 Viremia While this CCR5 antagonist has initially been used in salvage therapy, its excel... BeFree,GAD,LHGDN 24155059 Detail
0.004 Virus Diseases CCR5 deficiency predisposes to fatal outcome in influenza virus infection. BeFree 25918237 Detail
0.004 Virus Diseases These data bring new insights on the association between viral infections and th... BeFree 25939314 Detail
0.003 vitiligo NA BeFree,GAD Detail
0.125 West Nile fever NA CTD_human,GAD Detail
<0.001 yellow fever NA BeFree Detail
0.002 diffuse large B-cell lymphoma NA GAD Detail
<0.001 Lymphoma, AIDS-Related NA BeFree Detail
<0.001 severe combined immunodeficiency NA BeFree Detail
0.005 Bronchial Hyperreactivity NA GAD Detail
0.003 Arthritis, Reactive NA BeFree,GAD Detail
<0.001 acute leukemia The aim of this study was to investigate the mannose-binding lectin 2 (MBL-2), i... BeFree 24819208 Detail
0.003 Epstein-Barr Virus Infections NA BeFree,GAD Detail
0.002 Left Ventricular Hypertrophy NA GAD Detail
<0.001 Genital ulceration NA BeFree Detail
<0.001 Active tuberculosis NA BeFree Detail
<0.001 Primary Sj�gren's syndrome This meta-analysis demonstrates that the CCR5-Δ32 polymorphism is associated wit... BeFree 24599359 Detail
<0.001 Adenocarcinoma of lung (disorder) NA BeFree Detail
<0.001 Joint swelling NA BeFree Detail
<0.001 Idiopathic pulmonary hypertension NA BeFree Detail
<0.001 Systemic candidiasis NA BeFree Detail
<0.001 Malignant neoplasm of mouth NA BeFree Detail
<0.001 Secondary malignant neoplasm of lung NA BeFree Detail
<0.001 Secondary malignant neoplasm of bone CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed... BeFree 25452256 Detail
<0.001 allergic asthma NA BeFree Detail
<0.001 Infections specific to perinatal period NA BeFree Detail
0.080 Dermatitis, Allergic Contact NA RGD Detail
0.002 Aneurysm, Ruptured NA GAD Detail
0.008 Aortic Aneurysm, Abdominal NA BeFree,GAD,LHGDN Detail
<0.001 Tumor Progression NA BeFree Detail
0.004 Lichen Planus, Oral NA BeFree,LHGDN Detail
<0.001 Lip and oral cavity carcinoma NA BeFree Detail
<0.001 Chronic berylliosis NA BeFree Detail
<0.001 Morning stiffness (>1 hour) NA BeFree Detail
<0.001 pancreatic carcinoma NA BeFree Detail
<0.001 pediatric AIDS NA BeFree Detail
0.002 Renal transplant rejection NA GAD Detail
0.002 Malignant neoplasm of lung NA GAD Detail
0.003 Neoplasm, Residual NA BeFree,GAD Detail
<0.001 Mucosa-Associated Lymphoid Tissue Lymphoma NA BeFree Detail
0.005 Disease Progression NA GAD,LHGDN Detail
<0.001 Parasitemia NA BeFree Detail
<0.001 Ichthyosis linearis circumflexa NA BeFree Detail
<0.001 Vesicular Stomatitis NA BeFree Detail
<0.001 Coinfection NA BeFree Detail
<0.001 Metastatic melanoma NA BeFree Detail
0.003 Cancer of Head and Neck NA BeFree,GAD Detail
<0.001 Adenocarcinoma of pancreas NA BeFree Detail
<0.001 bubonic plague NA BeFree Detail
0.006 cervix carcinoma CCR5 expression is elevated in cervical cancer cells and is up-regulated by semi... BeFree,GAD 25103627 Detail
0.002 Restenosis NA GAD Detail
<0.001 Superficial ulcer NA BeFree Detail
<0.001 Rocio virus encephalitis NA BeFree Detail
0.002 Human immunodeficiency virus leukoencephalopathy NA GAD Detail
<0.001 Chronic liver disease NA BeFree Detail
<0.001 Asymptomatic human immunodeficiency virus infection NA BeFree Detail
0.003 Malignant neoplasm of pancreas NA BeFree,GAD Detail
<0.001 Disseminated Malignant Neoplasm NA BeFree Detail
<0.001 Human immunodeficiency virus, type 2 [HIV-2] infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
<0.001 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
0.004 Malignant neoplasm of prostate NA BeFree,GAD Detail
0.005 Hematologic Neoplasms NA GAD Detail
<0.001 Idiopathic crescentic glomerulonephritis NA BeFree Detail
<0.001 Infective vaginitis NA BeFree Detail
<0.001 neuropathy NA BeFree Detail
0.003 tick-borne encephalitis A possible association between predisposition to TBE in a Russian population and... BeFree 23721942 Detail
0.003 hiv-infection/aids Autologous Hematopoietic Stem Cells transplantation and genetic modification of ... BeFree 25613565 Detail
<0.001 dementia NA BeFree Detail
<0.001 Granulomatosis NA BeFree Detail
<0.001 Metabolic syndrome X NA BeFree Detail
0.005 Hepatitis B, Chronic NA GAD Detail
0.019 Hepatitis C, Chronic NA BeFree,GAD,LHGDN Detail
<0.001 primary sclerosing cholangitis NA BeFree Detail
<0.001 Osteosarcoma of bone CCL5/CCR5 axis induces vascular endothelial growth factor-mediated tumor angioge... BeFree 25330803 Detail
<0.001 Biliary stricture NA BeFree Detail
0.002 prostate carcinoma NA BeFree Detail
0.002 breast carcinoma Evaluation of CCL5 -403 G>A and CCR5 Δ32 gene polymorphisms in patients with bre... BeFree 25171476 Detail
0.002 breast carcinoma The potential to target CCL5/CCR5 in breast cancer. BeFree 25256399 Detail
<0.001 Terminal illness NA BeFree Detail
0.002 Hemophilia, NOS NA BeFree Detail
0.002 Pregnancy loss NA GAD Detail
<0.001 colon carcinoma NA BeFree Detail
<0.001 Carcinoma of bladder NA BeFree Detail
<0.001 Central neuroblastoma NA BeFree Detail
<0.001 AIDS defining illness NA BeFree Detail
<0.001 infertility tubal factor NA BeFree Detail
<0.001 lung disease granulomatous NA BeFree Detail
0.080 Hypoxia-Ischemia, Brain NA RGD Detail
<0.001 Acute GVH disease NA BeFree Detail
<0.001 Cardiomyopathies SNP/haplotype associations of CCR2 and CCR5 genes with severity of chagasic card... BeFree 25312802 Detail
<0.001 Metastatic Prostate Carcinoma CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed... BeFree 25452256 Detail
0.002 Acute coronary syndrome NA GAD Detail
0.001 Primary infection NOS NA BeFree Detail
<0.001 Colorectal cancer metastatic NA BeFree Detail
0.002 coronary restenosis NA GAD Detail
0.080 Arthritis, Experimental NA RGD Detail
0.002 West Nile viral infection NA BeFree Detail
0.012 HIV disease progression NA GAD Detail
<0.001 Primary HIV infection NA BeFree Detail
<0.001 Squamous cell carcinoma of the head and neck NA BeFree Detail
0.002 Systemic arterial pressure NA GAD Detail
<0.001 Inflammatory disorder Recent evidence has demonstrated the role of CCR5Δ32 in a variety of human disea... BeFree 25172974 Detail
<0.001 Aggressive natural killer-cell leukemia NA BeFree Detail
<0.001 Peripheral arterial occlusive disease NA BeFree Detail
<0.001 Pediatric human immunodeficiency virus infection NA BeFree Detail
0.003 mucocutaneous leishmaniasis NA BeFree,GAD Detail
0.006 Mammary Neoplasms Recent evidence has demonstrated the implication of CC chemokine ligand 5 (CCL5)... BeFree,GAD,LHGDN 25171476 Detail
<0.001 Neuropathogenesis NA BeFree Detail
<0.001 Tumor Angiogenesis CCL5/CCR5 axis induces vascular endothelial growth factor-mediated tumor angioge... BeFree 25330803 Detail
0.001 colorectal cancer We demonstrate that stronger secretion of CXCL10 (CXCR3 ligand) and CCL5 (CCR5 l... BeFree 25671296 Detail
0.002 Sjogren's syndrome NA GAD Detail
0.003 Pneumocystis jiroveci pneumonia NA BeFree,GAD Detail
<0.001 Ocular surface disease NA BeFree Detail
<0.001 Non-Malignant Ascites Adverse Event NA BeFree Detail
0.003 Renal Insufficiency NA BeFree,LHGDN Detail
<0.001 Upper urinary tract infection NA BeFree Detail
<0.001 MULTICYSTIC RENAL DYSPLASIA, BILATERAL NA BeFree Detail
0.002 Venous thromboembolism NA GAD Detail
0.088 coronary artery disease NA BeFree,GAD,RGD Detail
0.003 liver carcinoma NA BeFree,GAD Detail
0.001 Chronic kidney disease stage 5 NA BeFree Detail
0.002 HIV-1 infection NA GAD Detail
0.120 Acute kidney injury NA CTD_human Detail
0.120 DIABETES MELLITUS, INSULIN-DEPENDENT, 22 (disorder) NA CTD_human Detail
0.002 Chronic ulcerative colitis NA GAD Detail
<0.001 Pulmonary arterial hypertension NA BeFree Detail
0.009 Juvenile arthritis NA BeFree,GAD Detail
0.002 granulomatosis with polyangiitis NA GAD Detail
0.054 Infection NA LHGDN Detail
0.002 juvenile rheumatoid arthritis NA BeFree Detail
<0.001 Pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia NA BeFree Detail
<0.001 Flaviviral diseases NA BeFree Detail
0.045 acquired immunodeficiency syndrome NA BeFree,GAD,LHGDN Detail
0.005 adenocarcinoma NA LHGDN Detail
<0.001 AIDS Dementia Complex NA BeFree Detail
0.089 Alzheimer's disease NA GAD,RGD Detail
0.005 Anemia, Sickle Cell NA BeFree,GAD Detail
0.002 aortic valve stenosis NA GAD Detail
0.008 Arterial Occlusive Diseases NA BeFree,GAD,LHGDN Detail
0.002 arteriosclerosis NA BeFree Detail
0.004 arthritis NA BeFree,GAD Detail
0.003 Arthritis, Psoriatic NA BeFree,GAD Detail
0.032 rheumatoid arthritis In addition to the strong association between alleles of the HLA-DRB1*04 shared ... BeFree,GAD,LHGDN 25163740 Detail
0.032 rheumatoid arthritis CCL2, CCL4, c-Jun, c-Fos, and CCR5 may play an important role in the recruitment... BeFree,GAD,LHGDN 26069140 Detail
0.039 asthma NA BeFree,GAD,LHGDN Detail
<0.001 Astrocytoma NA BeFree Detail
0.012 atherosclerosis NA BeFree,GAD,LHGDN Detail
0.006 Behcet Syndrome Association of CCR5Δ32 and Behçet's disease: new data from a case-control study ... BeFree,GAD,LHGDN 26393284 Detail
0.002 berylliosis NA GAD Detail
0.002 Biliary Tract Diseases NA GAD Detail
0.003 Malignant neoplasm of urinary bladder NA BeFree,GAD Detail
<0.001 Bone Diseases NA BeFree Detail
0.002 Brain Neoplasms NA GAD Detail
0.004 Malignant neoplasm of breast Evaluation of CCL5 -403 G>A and CCR5 Δ32 gene polymorphisms in patients with bre... BeFree,GAD 25171476 Detail
0.004 Malignant neoplasm of breast The potential to target CCL5/CCR5 in breast cancer. BeFree,GAD 25256399 Detail
0.003 bronchiolitis NA BeFree,LHGDN Detail
0.002 Bronchiolitis, Viral NA GAD Detail
0.005 brucellosis NA BeFree,GAD,LHGDN Detail
<0.001 Malignant tumor of colon NA BeFree Detail
Annotation

Annotations

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CCR5 expression is elevated in cervical cancer cells and is up-regulated by seminal plasma. DisGeNET Detail
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We demonstrate that stronger secretion of CXCL10 (CXCR3 ligand) and CCL5 (CCR5 ligand) and infiltrat... DisGeNET Detail
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Here, we report generation of cystic fibrosis (CF) and Gaucher's disease (GD) hiPSCs respectively fr... DisGeNET Detail
Incidence and dynamics of active cytomegalovirus infection in allogeneic stem cell transplant patien... DisGeNET Detail
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Dengue virus requires the CC-chemokine receptor CCR5 for replication and infection development. DisGeNET Detail
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The CCR5 59029G>A and ELMO1 (+9170 G>A) loci are more frequent, and the SLC12A3 34372 AA genotype is... DisGeNET Detail
The CCR5 59029G>A and ELMO1 (+9170 G>A) loci are more frequent, and the SLC12A3 34372 AA genotype is... DisGeNET Detail
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Variations in CCR5, but not HFE, ELMO1, or SLC12A3, are associated with susceptibility to kidney dis... DisGeNET Detail
A set of 17 differentially expressed genes, not located on chromosome 21 (HSA21), involved in immune... DisGeNET Detail
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Independently of age, nonfunctional CCR5Δ32 mutation is a significant risk factor for development of... DisGeNET Detail
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Subsequent excision of the donor cassette was done by treating CCR5-modified CF and GD hiPSCs with C... DisGeNET Detail
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Several recent clinical trials were all based on previously reported findings from the mouse model o... DisGeNET Detail
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We will provide a rigorous review of the Bayesian variable partition model and the recursive model s... DisGeNET Detail
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Enhanced HIV-1 replication was associated with increased CD4, CCR5, and CD38 transcription (P<0.05) ... DisGeNET Detail
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Coreceptor tropism was completely concordant in paired pre-treatment RNA and DNA, with 26.2% of HIV-... DisGeNET Detail
HIV-1 uses the coreceptors CCR5 and/or CXCR4 for cell entry. DisGeNET Detail
Enhanced HIV-1 replication was associated with increased CD4, CCR5, and CD38 transcription (P<0.05) ... DisGeNET Detail
The CX3CR1 A allele and lower genetic scores may restrict the switch of HIV-1 tropism from R5 to X4. DisGeNET Detail
We investigated the impact of FGS on HIV target cell density and expression of the HIV co-receptor C... DisGeNET Detail
HIV-1 tropism dynamics and phylogenetic analysis from longitudinal ultra-deep sequencing data of CCR... DisGeNET Detail
When pDC were depleted prior to HIV-1 infection, the induction of IFN-I and interferon-stimulated ge... DisGeNET Detail
A 32-nucleotide deletion within the CCR5 reading frame is associated with decreased susceptibility t... DisGeNET Detail
Treatment intensification with maraviroc (CCR5 antagonist) leads to declines in CD16-expressing mono... DisGeNET Detail
The role of CCR5 in HIV infection led to the development of specific and potent CCR5 antagonists. DisGeNET Detail
This high prevalence of X4 virus might compromise the use of CCR5 inhibitors, currently mostly consi... DisGeNET Detail
We illustrate our approach with an analysis of the effect of the CCR5Δ32 mutation on HIV acquisition... DisGeNET Detail
Furthermore, a mutated virus that is capable of using both CCR5 and CXCR4 as entry coreceptor is spe... DisGeNET Detail
We will provide a rigorous review of the Bayesian variable partition model and the recursive model s... DisGeNET Detail
Replication competent recombinant viruses incorporating the HIV RNA+/Ab- as compared to the chronic ... DisGeNET Detail
CCR5 gene disruption via lentiviral vectors expressing Cas9 and single guided RNA renders cells resi... DisGeNET Detail
Genotyping of CCR5 gene, CCR2b and SDF1 variants related to HIV-1 infection in Gabonese subjects. DisGeNET Detail
CCR5 is a main cc-chemokine co-receptor that facilitates HIV-1 entry to macrophage and CD4(+) T cell... DisGeNET Detail
A deletion of 32bp (CCR5Δ32) in the CCR5 gene seems to protect against HIV-1, S.aureus and other inf... DisGeNET Detail
Studies of individuals who were highly exposed but seronegative (HESN) for HIV infection led to the ... DisGeNET Detail
The PhenoSeq platform will inform the appropriate use of maraviroc and future CCR5 blocking drugs in... DisGeNET Detail
Viremic control and viral coreceptor usage in two HIV-1-infected persons homozygous for CCR5 Δ32. DisGeNET Detail
The MIP-1α, MIP-1β, and RANTES chemokines are natural ligands of CCR5 and are known to interfere wit... DisGeNET Detail
However, the causes of resistance to HIV-1 infection in cases other than those with a homozygous CCR... DisGeNET Detail
Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 b... DisGeNET Detail
Herpes simplex virus type 2-infected dendritic cells produce TNF-α, which enhances CCR5 expression a... DisGeNET Detail
Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-deliv... DisGeNET Detail
Lentivector Knockdown of CCR5 in Hematopoietic Stem and Progenitor Cells Confers Functional and Pers... DisGeNET Detail
This study focuses on trafficking of CCR5, a GPCR chemokine receptor and the principal entry corecep... DisGeNET Detail
mRNA transfection of a novel TAL effector nuclease (TALEN) facilitates efficient knockout of HIV co-... DisGeNET Detail
The presence of CCR5-tropic variants in more than 85 % of our cohort of antiretroviral-naïve blood d... DisGeNET Detail
An impact of host genetic variation on HIV-1 susceptibility was identified early in the pandemic, wi... DisGeNET Detail
Over-expression of NHERF1 affects the ligands or HIV-1 gp120-induced CCR5 internalization and HIV-1 ... DisGeNET Detail
HIV-1 Nef, a key factor for viral pathogenesis, downregulates functionally important molecules from ... DisGeNET Detail
The entry inhibitor drug maraviroc makes the cell coreceptor CCR5 unavailable for use by HIV-1 and i... DisGeNET Detail
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We show that ex vivo SIV infection of lymphocytes from CCR5 wild-type SM is mediated by both CXCR6 a... DisGeNET Detail
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The CCR5Δ32 allele was not found to be associated with the risk of H1N1pdm09 infection or with a sev... DisGeNET Detail
CCR5 deficiency predisposes to fatal outcome in influenza virus infection. DisGeNET Detail
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Variations in CCR5, but not HFE, ELMO1, or SLC12A3, are associated with susceptibility to kidney dis... DisGeNET Detail
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This meta-analysis demonstrates that the CCR5-Δ32 polymorphism is associated with KD, but does not f... DisGeNET Detail
Chemokine receptor 5 (CCR5) delta 32 polymorphism in lupus nephritis: a large case-control study and... DisGeNET Detail
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However, the overall OR for the CCR5-Δ32 allele was significantly higher in Kawasaki disease (KD; OR... DisGeNET Detail
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The data reviewed here includes basic and translational studies that support the use of such CCR5 an... DisGeNET Detail
We demonstrate that stronger secretion of CXCL10 (CXCR3 ligand) and CCL5 (CCR5 ligand) and infiltrat... DisGeNET Detail
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The CCR5Δ32 could be associated with protection against osteomyelitis caused by S. aureus, corrobora... DisGeNET Detail
CCL5/CCR5 axis induces vascular endothelial growth factor-mediated tumor angiogenesis in human osteo... DisGeNET Detail
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HIV-1 Nef downregulates the viral entry receptor CD4 as well as the coreceptors CCR5 and CXCR4 from ... DisGeNET Detail
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Nine SNPs of CCR5 and CCR2 were typified to confirm the association previously found with Chagas dis... DisGeNET Detail
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While this CCR5 antagonist has initially been used in salvage therapy, its excellent safety profile ... DisGeNET Detail
CCR5 deficiency predisposes to fatal outcome in influenza virus infection. DisGeNET Detail
These data bring new insights on the association between viral infections and the chemokine receptor... DisGeNET Detail
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The aim of this study was to investigate the mannose-binding lectin 2 (MBL-2), interleukin (IL)-4, T... DisGeNET Detail
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This meta-analysis demonstrates that the CCR5-Δ32 polymorphism is associated with KD, but does not f... DisGeNET Detail
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CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate... DisGeNET Detail
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CCR5 expression is elevated in cervical cancer cells and is up-regulated by seminal plasma. DisGeNET Detail
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A possible association between predisposition to TBE in a Russian population and two polymorphisms, ... DisGeNET Detail
Autologous Hematopoietic Stem Cells transplantation and genetic modification of CCR5 m303/m303 mutan... DisGeNET Detail
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CCL5/CCR5 axis induces vascular endothelial growth factor-mediated tumor angiogenesis in human osteo... DisGeNET Detail
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Evaluation of CCL5 -403 G>A and CCR5 Δ32 gene polymorphisms in patients with breast cancer. DisGeNET Detail
The potential to target CCL5/CCR5 in breast cancer. DisGeNET Detail
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SNP/haplotype associations of CCR2 and CCR5 genes with severity of chagasic cardiomyopathy. DisGeNET Detail
CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate... DisGeNET Detail
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Recent evidence has demonstrated the role of CCR5Δ32 in a variety of human diseases: from infectious... DisGeNET Detail
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Recent evidence has demonstrated the implication of CC chemokine ligand 5 (CCL5) and CC chemokine re... DisGeNET Detail
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CCL5/CCR5 axis induces vascular endothelial growth factor-mediated tumor angiogenesis in human osteo... DisGeNET Detail
We demonstrate that stronger secretion of CXCL10 (CXCR3 ligand) and CCL5 (CCR5 ligand) and infiltrat... DisGeNET Detail
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In addition to the strong association between alleles of the HLA-DRB1*04 shared epitope and both sub... DisGeNET Detail
CCL2, CCL4, c-Jun, c-Fos, and CCR5 may play an important role in the recruitment of PB leukocytes in... DisGeNET Detail
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Association of CCR5Δ32 and Behçet's disease: new data from a case-control study in the Spanish popul... DisGeNET Detail
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Evaluation of CCL5 -403 G>A and CCR5 Δ32 gene polymorphisms in patients with breast cancer. DisGeNET Detail
The potential to target CCL5/CCR5 in breast cancer. DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386586050 dbSNP
Genome
hg38
Position
chr3:46,370,946-46,376,206
Variant Type
snv
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