Annotation Detail
Information
- Associated Genes
- CCR5
- Associated Variants
-
CCR5 MUTATION
CCR5 MUTATION - Associated Disease
- Superinfection
- Source Database
- DisGeNET
- Description
- HIV-1 Nef downregulates the viral entry receptor CD4 as well as the coreceptors CCR5 and CXCR4 from the surface of HIV-infected cells, and this leads to promotion of viral replication through superinfection resistance and other mechanisms.
- Pubmed
- 26178998
- Section of the abstract supporting the evidence
- UNLABELLED
- Number of the section of the abstract supporting the evidence
- 1
- Number of the sentence supporting the evidence
- 1
- Original source reporting the Gene Disease association
- BeFree,LHGDN
- DisGENET score for the Gene Disease association
- 0.00326723398662778
Drugs