chr20:5114953:> Detail (hg38)

Go to:

Summary
Information
Links
Disease area statistics
MGeND
ClinVar
CIViC
DisGeNET
Annotation
Genome browser

Information

Genome

Assembly	Position
hg19	chr20:5,095,599-5,107,272
hg38	chr20:5,114,953-5,126,626

HGVS

RefSeq

Type	Transcript	Protein

Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics	Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star	[No Data.]
Show details

Links

Disease area statistics

[No Data.]

MGeND

[No Data.]

ClinVar

[No Data.]

CIViC

[No Data.]

DisGeNET

Score	Disease name	Description	Source	Pubmed	Links
0.015	squamous cell carcinoma	Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell c...	BeFree,LHGDN	25013792	Detail
0.002	Carcinoma, Transitional Cell	NA	BeFree		Detail
<0.001	Cardiovascular Diseases	NA	BeFree		Detail
0.080	brain ischemia	NA	RGD		Detail
0.080	Transient ischemic attack	NA	RGD		Detail
0.004	Malignant tumor of cervix	Cyclin D1b overexpression inhibits cell proliferation and induces cell apoptosis...	BeFree	25120779	Detail
0.004	Malignant tumor of cervix	Long noncoding RNA CCHE1 promotes cervical cancer cell proliferation via upregul...	BeFree	25921283	Detail
<0.001	Cervix Diseases	NA	BeFree		Detail
0.003	Uterine Cervical Neoplasm	NA	BeFree,LHGDN		Detail
0.080	Chagas Cardiomyopathy	NA	RGD		Detail
<0.001	Primary biliary cirrhosis	NA	BeFree		Detail
<0.001	cholesteatoma	NA	BeFree		Detail
<0.001	Congenital chromosomal disease	NA	BeFree		Detail
0.120	Colonic Neoplasms	NA	CTD_human		Detail
<0.001	Colonic Polyps	NA	BeFree		Detail
0.007	colorectal carcinoma	NA	BeFree		Detail
0.006	Colorectal Neoplasms	NA	BeFree,GAD,LHGDN		Detail
<0.001	Condylomata Acuminata	NA	BeFree		Detail
<0.001	Coronary Arteriosclerosis	NA	BeFree		Detail
<0.001	Coronary heart disease	NA	BeFree		Detail
0.003	adenoid cystic carcinoma	NA	BeFree,LHGDN		Detail
<0.001	Diabetes	NA	BeFree		Detail
<0.001	diabetes mellitus	NA	BeFree		Detail
<0.001	Diabetes Mellitus, Non-Insulin-Dependent	NA	BeFree		Detail
<0.001	encephalitis	NA	BeFree		Detail
0.003	Endometrial Neoplasms	NA	LHGDN		Detail
<0.001	endometrial hyperplasia	NA	BeFree		Detail
0.001	endometriosis	NA	BeFree		Detail
<0.001	Esophageal Achalasia	NA	BeFree		Detail
0.006	Esophageal Neoplasms	Overexpression of cyclin B has been shown to affect survival in some malignant t...	BeFree,GAD	25315186	Detail
<0.001	Exanthema	NA	BeFree		Detail
<0.001	Fanconi anemia	NA	BeFree		Detail
<0.001	breast fibrocystic disease	NA	BeFree		Detail
0.002	glioblastoma	Glioblastoma development is often associated with alteration in the activity and...	BeFree	25817794	Detail
0.120	IgA glomerulonephritis	NA	BeFree,CTD_human		Detail
0.120	Focal glomerulosclerosis	NA	CTD_human		Detail
0.002	Graft-vs-Host Disease	NA	GAD		Detail
<0.001	granulosa cell tumor	NA	BeFree		Detail
<0.001	Graves Disease	NA	BeFree		Detail
0.002	Head and Neck Neoplasms	NA	GAD		Detail
<0.001	hemangioma	NA	BeFree		Detail
<0.001	Hematological Disease	NA	BeFree		Detail
<0.001	hepatitis	NA	BeFree		Detail
<0.001	hepatitis A	NA	BeFree		Detail
<0.001	hepatitis B	NA	BeFree		Detail
<0.001	hepatitis C	NA	BeFree		Detail
<0.001	Herpes Simplex Infections	NA	BeFree		Detail
0.003	HIV Infections	NA	BeFree		Detail
<0.001	Hodgkin Disease	NA	BeFree		Detail
<0.001	HTLV-I Infections	NA	BeFree		Detail
<0.001	hyperinsulinism	PCNA staining was increased 3- to 3.5-fold, indicating increased insulin-cell pr...	BeFree	24941889	Detail
<0.001	hypoglycemia	NA	BeFree		Detail
0.080	hypothyroidism	NA	RGD		Detail
0.121	ischemia	NA	BeFree,CTD_human		Detail
0.080	Jaundice, Obstructive	NA	RGD		Detail
<0.001	keratoacanthoma	NA	BeFree		Detail
<0.001	actinic keratosis	NA	BeFree		Detail
<0.001	Kidney Failure, Acute	The human DMTF1 (DMP1) transcription factor, a DNA binding protein that interact...	BeFree	26187004	Detail
0.002	Laryngeal neoplasm	NA	GAD		Detail
0.091	Fibroid Tumor	NA	BeFree,LHGDN,RGD		Detail
0.003	leukemia	Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acq...	BeFree	25596730	Detail
0.002	chronic lymphocytic leukemia	NA	BeFree		Detail
<0.001	Acute Erythroblastic Leukemia	NA	BeFree		Detail
<0.001	Acute lymphocytic leukemia	NA	BeFree		Detail
<0.001	Leukemia, Lymphocytic, Acute, L1	NA	BeFree		Detail
0.001	Leukemia, Myelocytic, Acute	NA	BeFree		Detail
0.002	Myeloid Leukemia, Chronic	NA	BeFree		Detail
<0.001	acute promyelocytic leukemia	NA	BeFree		Detail
<0.001	Leukemia, T-Cell	NA	BeFree		Detail
<0.001	Adult T-Cell Lymphoma/Leukemia	NA	BeFree		Detail
<0.001	Leukoencephalopathy, Progressive Multifocal	NA	BeFree		Detail
<0.001	Lichen Sclerosus et Atrophicus	NA	BeFree		Detail
<0.001	liver cirrhosis	NA	BeFree		Detail
0.002	Liver neoplasms	Knockout of SRC-1 in mice reduced diethylnitrosamine/CCl4-induced tumor formatio...	BeFree	26082485	Detail
0.002	Chronic Obstructive Airway Disease	NA	GAD		Detail
0.124	Lung Neoplasms	Our results imply that CXCL16-CXCR6 axis is involved in the regulation of viabil...	BeFree,CTD_human,LHGDN	24897301	Detail
<0.001	Lupus Vulgaris	NA	BeFree		Detail
<0.001	Lupus Erythematosus, Discoid	NA	BeFree		Detail
0.001	Lupus Erythematosus, Systemic	Autoantibodies to proliferating cell nuclear antigen (PCNA) are specifically, if...	BeFree	24836587	Detail
0.006	lymphoma	NA	BeFree		Detail
<0.001	Lymphoma, Follicular	We observed a significant increase in ΔNp73 expression and ΔNp73:TAp73 ratio, lo...	BeFree	24660851	Detail
0.010	Malignant neoplasm of stomach	Knockdown of EGFR reduced cell proliferation and invasion of GC with decreased e...	BeFree	25394504	Detail
0.010	Malignant neoplasm of stomach	Functional analysis studies revealed that ectopic expression of miR-133a reduced...	BeFree	25620172	Detail
0.080	Mammary Neoplasms, Experimental	NA	RGD		Detail
<0.001	megaesophagus	NA	BeFree		Detail
0.017	melanoma	Using A375 (BRAF-mutated) and Hs294t (non BRAF-mutated but highly metastatic) hu...	BeFree,LHGDN	25174976	Detail
0.017	melanoma	Cell cycle control is a promising target in the management of melanoma with earl...	BeFree,LHGDN	25588041	Detail
0.002	Meningeal Neoplasms	NA	GAD		Detail
0.003	meningioma	NA	BeFree,GAD		Detail
<0.001	Microphthalmos	NA	BeFree		Detail
<0.001	Mixed Salivary Gland Tumor	NA	BeFree		Detail
0.002	Mouth Neoplasms	NA	GAD		Detail
0.010	multiple myeloma	Inhibitors of cyclin-dependent kinases 9 have been developed as potential antica...	BeFree,LHGDN	24803299	Detail
0.002	multiple sclerosis	NA	GAD		Detail
<0.001	Neck Neoplasms	NA	BeFree		Detail
<0.001	Neonatal hepatitis	NA	BeFree		Detail
0.008	Neoplasm Metastasis	Our results imply that CXCL16-CXCR6 axis is involved in the regulation of viabil...	BeFree	24897301	Detail
0.120	Neoplasms, Experimental	NA	CTD_human		Detail
<0.001	multiple endocrine neoplasia	NA	BeFree		Detail
<0.001	nephritis	NA	BeFree		Detail
<0.001	nephroblastoma	NA	BeFree		Detail
<0.001	nervous system disorder	NA	BeFree		Detail
0.004	neuroblastoma	NA	BeFree		Detail
0.003	acoustic neuroma	NA	BeFree,GAD		Detail
<0.001	Melanocytic nevus	NA	BeFree		Detail
0.007	Glioma	The XRCC1 Arg194Trp variant affects the proliferating cell nuclear antigen( PCNA...	BeFree	25227852	Detail
<0.001	obesity	NA	BeFree		Detail
<0.001	Odontogenic Tumors	NA	BeFree		Detail
<0.001	oligodendroglioma	NA	BeFree		Detail
0.080	osteoporosis	NA	RGD		Detail
0.002	osteosarcoma	Overexpression of RASSF5 markedly suppressed cell proliferation and invasion, an...	BeFree	25109282	Detail
0.002	osteosarcoma	Inhibition of osteosarcoma cell progression by MacroH2A via the downregulation o...	BeFree	25378143	Detail
0.002	osteosarcoma	When HMGN2 expression was enhanced, the expression of cyclin D1 and PCNA was dow...	BeFree	25530340	Detail
0.002	osteosarcoma	Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and...	BeFree	26434118	Detail
0.006	ovarian carcinoma	Cell growth was inhibited by the overexpression of miR-138, although not by the ...	BeFree	25190487	Detail
0.006	ovarian carcinoma	Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and...	BeFree	26434118	Detail
0.008	Pancreatic Neoplasm	P27(Kip1) expression and cleaved caspase-3 are increased, while cyclin E express...	BeFree,LHGDN	25677816	Detail
<0.001	Parkinson disease	Our results indicate that the interaction of PCNA and DNA pol-β contributes to n...	BeFree	25184665	Detail
<0.001	periodontitis	However, susceptibility genes, such as CDKN2BAS (Cyclin Dependend KiNase 2B Anti...	BeFree	24528298	Detail
0.002	Pharyngeal Neoplasms	NA	GAD		Detail
0.001	pituitary adenoma	NA	BeFree		Detail
0.001	Pituitary Diseases	MEG3, HOTAIR, MALAT-1 and proliferating cell nuclear antigen (PCNA) were detecte...	BeFree	24469926	Detail
0.001	Pituitary Diseases	Pituitary cyclin E/E2F1 signaling is a previously unappreciated molecular mechan...	BeFree	25942479	Detail
0.003	Pituitary Neoplasms	NA	LHGDN		Detail
<0.001	placental insufficiency	NA	BeFree		Detail
<0.001	plague	NA	BeFree		Detail
<0.001	plasmacytoma	NA	BeFree		Detail
<0.001	polycystic ovary syndrome	Our results indicated that the downregulation of CFTR in the cystic follicles wa...	BeFree	25646509	Detail
0.001	Adenomatous Polyposis Coli	NA	BeFree		Detail
0.001	Precancerous Conditions	NA	BeFree		Detail
<0.001	Preleukemia	NA	BeFree		Detail
0.003	prolactinoma	NA	BeFree,LHGDN		Detail
0.003	Prostatic Neoplasms	NA	BeFree,LHGDN		Detail
0.120	psoriasis	NA	BeFree,CTD_human		Detail
<0.001	pterygium	NA	BeFree		Detail
<0.001	Rectal Neoplasms	NA	BeFree		Detail
0.014	retinoblastoma	The data demonstrated that the expression of P21, cyclin D and phosphorylated re...	BeFree	25338527	Detail
0.014	retinoblastoma	Cyclin-dependent kinase inhibitors (CDKi) target the retinoblastoma (RB) signali...	BeFree	25557169	Detail
<0.001	Rett syndrome	NA	BeFree		Detail
<0.001	rhabdomyosarcoma	NA	BeFree		Detail
0.002	Kaposi sarcoma	NA	BeFree		Detail
<0.001	schistosomiasis	NA	BeFree		Detail
<0.001	Seizures	NA	BeFree		Detail
<0.001	seminoma	NA	BeFree		Detail
<0.001	Shy-Drager Syndrome	NA	BeFree		Detail
<0.001	Skin Neoplasms	NA	BeFree		Detail
0.003	Skin Ulcer	NA	LHGDN		Detail
0.003	Stomach Neoplasms	NA	BeFree,LHGDN		Detail
<0.001	teratoma	NA	BeFree		Detail
<0.001	Testicular Neoplasms	NA	BeFree		Detail
<0.001	Thromboembolism	NA	BeFree		Detail
<0.001	Thyroid Neoplasm	NA	BeFree		Detail
<0.001	Trisomy	NA	BeFree		Detail
<0.001	Chagas disease	NA	BeFree		Detail
0.003	tuberous sclerosis	NA	BeFree,LHGDN		Detail
0.003	Uterine Fibroids	NA	BeFree		Detail
<0.001	Virus Diseases	NA	BeFree		Detail
<0.001	common wart	NA	BeFree		Detail
<0.001	Fibromatosis, Aggressive	NA	BeFree		Detail
0.001	B-Cell Lymphomas	NA	BeFree		Detail
<0.001	High Grade Lymphoma (neoplasm)	NA	BeFree		Detail
0.001	diffuse large B-cell lymphoma	NA	BeFree		Detail
<0.001	T-Cell Lymphoma	NA	BeFree		Detail
<0.001	severe combined immunodeficiency	NA	BeFree		Detail
<0.001	Li-Fraumeni syndrome	NA	BeFree		Detail
<0.001	Neurofibrillary degeneration (morphologic abnormality)	NA	BeFree		Detail
<0.001	Polycystic Kidney, Autosomal Dominant	NA	BeFree		Detail
<0.001	autosomal recessive polycystic kidney disease	NA	BeFree		Detail
<0.001	Encephalopathies	NA	BeFree		Detail
<0.001	acute leukemia	NA	BeFree		Detail
<0.001	cataract	NA	BeFree		Detail
<0.001	benign neoplasm	NA	BeFree		Detail
<0.001	Small cell carcinoma of lung	In the present study we have mined these two studies for new therapeutic agents ...	BeFree	25198282	Detail
0.080	sciatic neuropathy	NA	RGD		Detail
<0.001	Thyroid Gland Follicular Adenoma	NA	BeFree		Detail
<0.001	Cutaneous Melanoma	NA	BeFree		Detail
<0.001	Adenocarcinoma of lung (disorder)	NA	BeFree		Detail
0.004	esophageal carcinoma	Overexpression of cyclin B has been shown to affect survival in some malignant t...	BeFree	25315186	Detail
<0.001	Malignant neoplasm of testis	NA	BeFree		Detail
<0.001	Secondary malignant neoplasm of lung	NA	BeFree		Detail
<0.001	Cleft palate with cleft lip	RA treatment reduced the expression of several of the investigated genes; the pr...	BeFree	24509616	Detail
<0.001	adrenoleukodystrophy	NA	BeFree		Detail
<0.001	porphyria cutanea tarda	NA	BeFree		Detail
0.003	Cicatrix, Hypertrophic	NA	LHGDN		Detail
<0.001	Russell-Silver syndrome	NA	BeFree		Detail
0.003	Williams syndrome	NA	LHGDN		Detail
0.005	Tumor Progression	NA	BeFree		Detail
<0.001	follicular adenoma	NA	BeFree		Detail
<0.001	Undifferentiated carcinoma	NA	BeFree		Detail
0.002	Germ cell tumor	NA	BeFree		Detail
<0.001	Pneumonia, Interstitial	NA	BeFree		Detail
0.003	Lichen Planus, Oral	NA	LHGDN		Detail
<0.001	adenomyoma	NA	BeFree		Detail
0.121	hepatoblastoma	NA	BeFree,CTD_human		Detail
<0.001	Giant Cell Tumor of Bone	NA	BeFree		Detail
<0.001	embryonal carcinoma	NA	BeFree		Detail
<0.001	Adenocarcinoma, Clear Cell	NA	BeFree		Detail
<0.001	Medullary carcinoma	NA	BeFree		Detail
<0.001	cholangiocarcinoma	NA	BeFree		Detail
0.001	Cervical Intraepithelial Neoplasia	NA	BeFree		Detail
<0.001	Squamous Cell Neoplasms	NA	BeFree		Detail
<0.001	inverted papilloma	Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell c...	BeFree	25013792	Detail
<0.001	Nevus, Blue	NA	BeFree		Detail
<0.001	Rhabdoid Tumor	NA	BeFree		Detail
<0.001	Neuroendocrine Tumors	NA	BeFree		Detail
<0.001	uveal melanoma	NA	BeFree		Detail
<0.001	Renal Pelvis and Ureter Urothelial Carcinoma	NA	BeFree		Detail
<0.001	pituitary-dependent Cushing's disease	Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target f...	BeFree	25942479	Detail
<0.001	Lesion of brain	NA	BeFree		Detail
<0.001	Fibrillation	NA	BeFree		Detail
<0.001	Memory impairment	NA	BeFree		Detail
0.002	pancreatic carcinoma	In conclusion, the present study reveals that the increased expression of OCT4 i...	BeFree	25017645	Detail
0.002	pancreatic carcinoma	Consistent with this, CST1 mRNA overexpression was correlated closely with malig...	BeFree	25577248	Detail
<0.001	Gastrointestinal Stromal Tumors	NA	BeFree		Detail
<0.001	Anaplastic thyroid carcinoma	NA	BeFree		Detail
<0.001	Medullary carcinoma of thyroid	NA	BeFree		Detail
0.001	Papillary thyroid carcinoma	NA	BeFree		Detail
<0.001	islet cell tumor	NA	BeFree		Detail
0.009	Malignant neoplasm of lung	These effects may result from the ability of miR-5100 to promote G1/S transition...	BeFree,GAD	25754817	Detail
<0.001	Proliferative vitreoretinopathy	Overexpression p21WAF1/CIP1 in suppressing retinal pigment epithelial cells and ...	BeFree	25421815	Detail
<0.001	Carcinoma, Lewis Lung	NA	BeFree		Detail
<0.001	Malignant Meningioma	NA	BeFree		Detail
<0.001	Collagen-vascular disease	NA	BeFree		Detail
<0.001	parathyroid adenoma	NA	BeFree		Detail
<0.001	Epithelial hyperplasia of skin	NA	BeFree		Detail
<0.001	Acute respiratory failure	The human DMTF1 (DMP1) transcription factor, a DNA binding protein that interact...	BeFree	26187004	Detail
<0.001	Liver cyst	NA	BeFree		Detail
<0.001	Xeroderma pigmentosum, group A	NA	BeFree		Detail
<0.001	Renal glomerular disease	NA	BeFree		Detail
<0.001	Simple renal cyst	NA	BeFree		Detail
<0.001	Coinfection	NA	BeFree		Detail
<0.001	Malignant neoplasm of colon stage IV	NA	BeFree		Detail
<0.001	Carcinoma breast stage IV	NA	BeFree		Detail
<0.001	gastric adenocarcinoma	COX-2 inhibitor celecoxib also suppressed the proliferative activities of GAC ce...	BeFree	24992958	Detail
<0.001	Metastatic melanoma	NA	BeFree		Detail
<0.001	Liver and Intrahepatic Biliary Tract Carcinoma	Downregulation of NF-κB, cyclin D1, cyclin E1, matrix metalloproteinases (MMP)-2...	BeFree	24972653	Detail
0.001	Squamous cell carcinoma of esophagus	NA	BeFree		Detail
<0.001	Adenocarcinoma Of Esophagus	NA	BeFree		Detail
<0.001	cervical squamous cell carcinoma	NA	BeFree		Detail
<0.001	cervical adenocarcinoma	NA	BeFree		Detail
<0.001	Transitional cell carcinoma of bladder	NA	BeFree		Detail
<0.001	Solid tumour	NA	BeFree		Detail
<0.001	stage, Kaposi's sarcoma	NA	BeFree		Detail
<0.001	stage, non-small cell lung cancer	NA	BeFree		Detail
<0.001	laryngeal squamous cell carcinoma	NA	BeFree		Detail
<0.001	benign meningioma	NA	BeFree		Detail
0.004	cervix carcinoma	Cyclin D1b overexpression inhibits cell proliferation and induces cell apoptosis...	BeFree	25120779	Detail
0.004	cervix carcinoma	Long noncoding RNA CCHE1 promotes cervical cancer cell proliferation via upregul...	BeFree	25921283	Detail
<0.001	Restenosis	NA	BeFree		Detail
0.080	Inflammatory disease of mucous membrane	NA	RGD		Detail
<0.001	Triploidy syndrome	NA	BeFree		Detail
<0.001	High-Grade Squamous Intraepithelial Lesions	NA	BeFree		Detail
<0.001	Cellular Blue Nevus	NA	BeFree		Detail
<0.001	Teratoma, Malignant	NA	BeFree		Detail
0.002	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	NA	BeFree		Detail
<0.001	Non-Functioning Pituitary Gland Neoplasm	Furthermore, PCNA mRNA levels markedly increased in invasive NFPAs compared to n...	BeFree	24469926	Detail
<0.001	Adenocarcinoma of colon	NA	BeFree		Detail
<0.001	Jaw Keratocyst	NA	BeFree		Detail
<0.001	Chronic liver disease	NA	BeFree		Detail
<0.001	Malignant neoplasm of liver	Downregulation of NF-κB, cyclin D1, cyclin E1, matrix metalloproteinases (MMP)-2...	BeFree	24972653	Detail
0.002	Malignant neoplasm of pancreas	In conclusion, the present study reveals that the increased expression of OCT4 i...	BeFree	25017645	Detail
0.002	Malignant neoplasm of pancreas	Consistent with this, CST1 mRNA overexpression was correlated closely with malig...	BeFree	25577248	Detail
<0.001	Anal intraepithelial neoplasia	NA	BeFree		Detail
<0.001	Early gastric cancer	NA	BeFree		Detail
<0.001	gastric lymphoma	NA	BeFree		Detail
<0.001	Atypical endometrial hyperplasia	NA	BeFree		Detail
<0.001	Skin callus	NA	BeFree		Detail
0.007	Malignant neoplasm of prostate	Antitumor effects of a novel small molecule targeting PCNA chromatin association...	BeFree	25253786	Detail
<0.001	Hematopoietic Neoplasms	NA	BeFree		Detail
0.003	Hematologic Neoplasms	NA	BeFree,GAD		Detail
<0.001	Plasma cell inflammation	NA	BeFree		Detail
<0.001	multiple system atrophy	NA	BeFree		Detail
<0.001	Hereditary gingival fibromatosis	NA	BeFree		Detail
<0.001	lupus erythematosus	NA	BeFree		Detail
<0.001	Hemimegalencephaly	NA	BeFree		Detail
0.004	endometrial carcinoma	Overexpression of cyclin B has been shown to affect survival in some malignant t...	BeFree	25315186	Detail
<0.001	Secondary malignant neoplasm of liver	NA	BeFree		Detail
<0.001	Benign neoplasm of liver	NA	BeFree		Detail
<0.001	Benign neurologic neoplasms	NA	BeFree		Detail
<0.001	Chronic active hepatitis	NA	BeFree		Detail
<0.001	Buffalo hump	NA	BeFree		Detail
0.001	Neurodegenerative Disorders	NA	BeFree		Detail
<0.001	Hepatitis B, Chronic	NA	BeFree		Detail
0.004	Malignant neoplasm of esophagus	Overexpression of cyclin B has been shown to affect survival in some malignant t...	BeFree	25315186	Detail
0.001	Thyroid carcinoma	Doxorubicin (DOX), a broad‑spectrum anthra-cyclin, is in wide clinical use for t...	BeFree	25592304	Detail
<0.001	Ewings sarcoma	NA	BeFree		Detail
<0.001	Oropharyngeal disorders	NA	BeFree		Detail
<0.001	Malignant glioma	NA	BeFree		Detail
0.002	Osteosarcoma of bone	Overexpression of RASSF5 markedly suppressed cell proliferation and invasion, an...	BeFree	25109282	Detail
0.002	Osteosarcoma of bone	Inhibition of osteosarcoma cell progression by MacroH2A via the downregulation o...	BeFree	25378143	Detail
0.002	Osteosarcoma of bone	When HMGN2 expression was enhanced, the expression of cyclin D1 and PCNA was dow...	BeFree	25530340	Detail
0.002	Osteosarcoma of bone	Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and...	BeFree	26434118	Detail
<0.001	Carcinoma of larynx	NA	BeFree		Detail
0.023	Carcinogenesis	Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis.	BeFree	25267403	Detail
0.023	Carcinogenesis	Genetic alteration of cyclin-dependent kinase inhibitors has been associated wit...	BeFree	25695279	Detail
0.023	Carcinogenesis	RV-cyclin presents a novel and ancient mechanism of retrovirus-induced oncogenes...	BeFree	25741012	Detail
0.023	Carcinogenesis	This study was performed to screen cyclin D1 (CCND1) and cyclin dependent kinase...	BeFree	26416047	Detail
<0.001	Leukemogenesis	NA	BeFree		Detail
<0.001	Tumor Initiation	NA	BeFree		Detail
0.007	prostate carcinoma	Antitumor effects of a novel small molecule targeting PCNA chromatin association...	BeFree	25253786	Detail
<0.001	CARCINOMA OF VULVA	NA	BeFree		Detail
<0.001	Epithelial ovarian cancer	Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and...	BeFree	26434118	Detail
<0.001	invasive cancer	NA	BeFree		Detail
0.005	Carcinoma of lung	These effects may result from the ability of miR-5100 to promote G1/S transition...	BeFree	25754817	Detail
0.005	Secondary malignant neoplasm of lymph node	As a consequence, the expression of COX-2 and PCNA was found in cancer tissues w...	BeFree	24992958	Detail
0.004	colon carcinoma	Cyclin-dependent kinase 8 (CDK8), a gene encoding the cyclin-dependent kinase (C...	BeFree	25305448	Detail
0.010	stomach carcinoma	Knockdown of EGFR reduced cell proliferation and invasion of GC with decreased e...	BeFree	25394504	Detail
0.010	stomach carcinoma	Functional analysis studies revealed that ectopic expression of miR-133a reduced...	BeFree	25620172	Detail
0.004	Carcinoma of bladder	RNA interference of HMGB3 in UBC cell lines inhibited cancer cell growth and mig...	BeFree	25647262	Detail
0.004	Central neuroblastoma	NA	BeFree		Detail
<0.001	Dissecting aneurysm of the thoracic aorta	NA	BeFree		Detail
<0.001	cervical cancer squamous cell	NA	BeFree		Detail
<0.001	Arnold-Chiari Malformation, Type I	NA	BeFree		Detail
<0.001	Well Differentiated Oligodendroglioma	NA	BeFree		Detail
<0.001	familial retinoblastoma	NA	BeFree		Detail
<0.001	Spots on skin	NA	BeFree		Detail
<0.001	Testicular malignant germ cell tumor	NA	BeFree		Detail
<0.001	breast adenocarcinoma	NA	BeFree		Detail
<0.001	Carcinoma, Pancreatic Ductal	NA	BeFree		Detail
0.002	ovarian neoplasm	NA	BeFree		Detail
<0.001	Vascular inflammations	NA	BeFree		Detail
<0.001	Ovarian adenocarcinoma	NA	BeFree		Detail
<0.001	Tauopathies	NA	BeFree		Detail
<0.001	Invasive Ductal Breast Carcinoma	NA	BeFree		Detail
0.007	Malignant neoplasm of ovary	Cell growth was inhibited by the overexpression of miR-138, although not by the ...	BeFree,GAD	25190487	Detail
<0.001	endometrial adenocarcinoma	NA	BeFree		Detail
<0.001	Squamous cell carcinoma of the head and neck	NA	BeFree		Detail
<0.001	Ductal Carcinoma	NA	BeFree		Detail
0.004	sarcoma	NA	BeFree		Detail
<0.001	Lymphocytic infiltration	NA	BeFree		Detail
<0.001	basaloid squamous cell carcinoma	NA	BeFree		Detail
0.001	Primary Effusion Lymphoma	NA	BeFree		Detail
<0.001	Salivary duct carcinoma	NA	BeFree		Detail
<0.001	Adenoma of large intestine	NA	BeFree		Detail
<0.001	Low Grade Squamous Intraepithelial Neoplasia	NA	BeFree		Detail
<0.001	ACTH-secreting pituitary adenoma	NA	BeFree		Detail
<0.001	Astrocytoma, low grade	NA	BeFree		Detail
<0.001	Adenocarcinoma of large intestine	NA	BeFree		Detail
<0.001	autoimmune lymphoproliferative syndrome	Further study indicated that most of the genes in the coexpression network were ...	BeFree	25299107	Detail
<0.001	B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma	NA	BeFree		Detail
<0.001	Invasive Carcinoma	NA	BeFree		Detail
<0.001	pancreatic ductal adenocarcinoma	NA	BeFree		Detail
<0.001	Sporadic Breast Carcinoma	NA	BeFree		Detail
<0.001	Endometrial Endometrioid Adenocarcinoma	Prognostic value of cyclin B in endometrial endometrioid adenocarcinoma.	BeFree	25315186	Detail
<0.001	Endometrial Endometrioid Adenocarcinoma	Cyclin E Expression Correlates with Cancer-specific Survival in Endometrial Endo...	BeFree	26026100	Detail
<0.001	carcinoma of the renal pelvis and ureter	NA	BeFree		Detail
<0.001	Benign melanocytic nevus	NA	BeFree		Detail
0.008	Mammary Neoplasms	NA	BeFree,LHGDN		Detail
<0.001	Breast Cancer Model	NA	BeFree		Detail
<0.001	Hepatocarcinogenesis	NA	BeFree		Detail
<0.001	Mammary Tumorigenesis	NA	BeFree		Detail
<0.001	Cancer Cell Growth	RNA interference of HMGB3 in UBC cell lines inhibited cancer cell growth and mig...	BeFree	25647262	Detail
<0.001	Xenograft Model	NA	BeFree		Detail
0.007	colorectal cancer	NA	BeFree,GAD		Detail
<0.001	Ductal Breast Carcinoma	NA	BeFree		Detail
<0.001	Rectal Tumors	NA	BeFree		Detail
<0.001	smoldering myeloma	NA	BeFree		Detail
<0.001	Cirrhosis	NA	BeFree		Detail
0.001	androgen independent prostate cancer	NA	BeFree		Detail
<0.001	Invasive Skin Melanoma	NA	BeFree		Detail
<0.001	Non-Neoplastic Disorder	NA	BeFree		Detail
<0.001	Primary Focal Segmental Glomerulosclerosis	NA	BeFree		Detail
<0.001	Meningioma, benign, no ICD-O subtype	NA	BeFree		Detail
<0.001	Idiopathic Pulmonary Fibrosis	NA	BeFree		Detail
<0.001	Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies	NA	BeFree		Detail
<0.001	Familial primary gastric lymphoma	NA	BeFree		Detail
<0.001	lateral meningocele syndrome	NA	BeFree		Detail
<0.001	Inverted Squamous Cell Papilloma	Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell c...	BeFree	25013792	Detail
0.001	uterine corpus cancer	Overexpression of cyclin B has been shown to affect survival in some malignant t...	BeFree	25315186	Detail
<0.001	coronary artery disease	NA	BeFree		Detail
0.004	Non-small cell lung carcinoma	Our results indicate that SNPs in the NER genes ERCC1 (Asn118Asn, 15310G>C, 8...	BeFree	16195237	Detail
<0.001	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	NA	BeFree		Detail
<0.001	Precursor Cell Lymphoblastic Leukemia Lymphoma	NA	BeFree		Detail
<0.001	low grade glioma	The protein expression of PCNA and EGFR was significantly higher in high-grade t...	BeFree	25688509	Detail
0.107	liver carcinoma	Silencing ARPP-19 in HCC cells resulted in decreased protein levels of phospho-(...	BeFree,LHGDN,RGD	25547487	Detail
0.107	liver carcinoma	Consistent with these results, the expression of SRC-1 was positively correlated...	BeFree,LHGDN,RGD	26082485	Detail
<0.001	Promyelocytic leukemia	NA	BeFree		Detail
0.001	Nasopharyngeal carcinoma	NA	BeFree		Detail
<0.001	X-linked infantile spasm syndrome	NA	BeFree		Detail
<0.001	Pilar and trichilemmal cysts	NA	BeFree		Detail
0.003	myelodysplastic syndrome	NA	BeFree,LHGDN		Detail
<0.001	FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)	NA	BeFree		Detail
<0.001	PSEUDOHYPOALDOSTERONISM, TYPE IID	Moreover, these animals exhibited renal inflammation, fibrosis, and increased cy...	BeFree	25250572	Detail
<0.001	Warts	NA	BeFree		Detail
0.005	Infection	NA	LHGDN		Detail
0.240	Ataxia-telangiectasia-like disorder 2	NA	ORPHANET,UNIPROT		Detail
<0.001	Congenital Abnormality	NA	BeFree		Detail
0.129	adenocarcinoma	NA	BeFree,CTD_human,LHGDN		Detail
0.009	adenoma	NA	BeFree,LHGDN		Detail
<0.001	Adenovirus Infections	Key messages: Cyclin E promoter activity is high in cancer cells and enhanced by...	BeFree	25376708	Detail
<0.001	adrenal gland hyperfunction	Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target f...	BeFree	25942479	Detail
0.003	AIDS Dementia Complex	NA	LHGDN		Detail
<0.001	Alzheimer's disease	We have previously found that cyclin E expression is augmented in cancer cells a...	BeFree	25376708	Detail
<0.001	Arthritis, Adjuvant-Induced	NA	BeFree		Detail
<0.001	rheumatoid arthritis	RA treatment reduced the expression of several of the investigated genes; the pr...	BeFree	24509616	Detail
<0.001	asthma	NA	BeFree		Detail
0.002	Astrocytoma	NA	BeFree		Detail
<0.001	ataxia telangiectasia	NA	BeFree		Detail
<0.001	Basal Cell Nevus Syndrome	NA	BeFree		Detail
0.001	Beckwith-Wiedemann syndrome	Here we report that p57Kip2, a cyclin-dependent kinase (CDK) inhibitor implicate...	BeFree	25195859	Detail
0.001	Beckwith-Wiedemann syndrome	Cyclin-dependent kinase (CDK)-inhibitor 1C (CDKN1C) negatively regulates cellula...	BeFree	25262539	Detail
<0.001	Benign Ovarian Neoplasm	NA	BeFree		Detail
0.011	Malignant neoplasm of urinary bladder	RNA interference of HMGB3 in UBC cell lines inhibited cancer cell growth and mig...	BeFree,GAD	25647262	Detail
<0.001	Bladder Neoplasm	NA	BeFree		Detail
<0.001	Blast Phase	NA	BeFree		Detail
<0.001	borderline personality disorder	NA	BeFree		Detail
0.123	Brain Neoplasms	NA	BeFree,CTD_human,GAD		Detail
0.003	Breast Diseases	NA	LHGDN		Detail
<0.001	bronchopulmonary dysplasia	NA	BeFree		Detail
<0.001	Burkitt lymphoma	NA	BeFree		Detail
<0.001	Carcinoid Tumor	NA	BeFree		Detail
0.004	Malignant tumor of colon	Cyclin-dependent kinase 8 (CDK8), a gene encoding the cyclin-dependent kinase (C...	BeFree	25305448	Detail
0.001	Malignant neoplasm of endometrium	Overexpression of cyclin B has been shown to affect survival in some malignant t...	BeFree	25315186	Detail
<0.001	Adenocarcinoma of prostate	NA	BeFree		Detail
<0.001	Malignant neoplasm of thyroid	Doxorubicin (DOX), a broad‑spectrum anthra-cyclin, is in wide clinical use for t...	BeFree	25592304	Detail
<0.001	Noninfiltrating Intraductal Carcinoma	NA	BeFree		Detail
0.004	Non-small cell lung carcinoma	NA	BeFree		Detail
0.003	renal cell carcinoma	NA	BeFree		Detail

Annotation

Annotations

Descrption	Source	Links
Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell carcinoma transformat...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Cyclin D1b overexpression inhibits cell proliferation and induces cell apoptosis in cervical cancer ...	DisGeNET	Detail
Long noncoding RNA CCHE1 promotes cervical cancer cell proliferation via upregulating PCNA.	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Overexpression of cyclin B has been shown to affect survival in some malignant tumors, including bre...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Glioblastoma development is often associated with alteration in the activity and expression of cell ...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
PCNA staining was increased 3- to 3.5-fold, indicating increased insulin-cell proliferation compared...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
The human DMTF1 (DMP1) transcription factor, a DNA binding protein that interacts with cyclin D, is ...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to ...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Knockout of SRC-1 in mice reduced diethylnitrosamine/CCl4-induced tumor formation in the liver and t...	DisGeNET	Detail
NA	DisGeNET	Detail
Our results imply that CXCL16-CXCR6 axis is involved in the regulation of viability and invasion rat...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Autoantibodies to proliferating cell nuclear antigen (PCNA) are specifically, if rarely, present in ...	DisGeNET	Detail
NA	DisGeNET	Detail
We observed a significant increase in ΔNp73 expression and ΔNp73:TAp73 ratio, lower expression of cl...	DisGeNET	Detail
Knockdown of EGFR reduced cell proliferation and invasion of GC with decreased expression of AKT, PC...	DisGeNET	Detail
Functional analysis studies revealed that ectopic expression of miR-133a reduced cell proliferation ...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Using A375 (BRAF-mutated) and Hs294t (non BRAF-mutated but highly metastatic) human melanoma cell li...	DisGeNET	Detail
Cell cycle control is a promising target in the management of melanoma with early data reporting the...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Inhibitors of cyclin-dependent kinases 9 have been developed as potential anticancer drugs for the t...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Our results imply that CXCL16-CXCR6 axis is involved in the regulation of viability and invasion rat...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
The XRCC1 Arg194Trp variant affects the proliferating cell nuclear antigen( PCNA) binding region, wh...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Overexpression of RASSF5 markedly suppressed cell proliferation and invasion, and induced cell apopt...	DisGeNET	Detail
Inhibition of osteosarcoma cell progression by MacroH2A via the downregulation of cyclin D and cycli...	DisGeNET	Detail
When HMGN2 expression was enhanced, the expression of cyclin D1 and PCNA was downregulated in osteos...	DisGeNET	Detail
Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and Osteosarcoma Cell L...	DisGeNET	Detail
Cell growth was inhibited by the overexpression of miR-138, although not by the knockout of Limk1. m...	DisGeNET	Detail
Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and Osteosarcoma Cell L...	DisGeNET	Detail
P27(Kip1) expression and cleaved caspase-3 are increased, while cyclin E expression is decreased, in...	DisGeNET	Detail
Our results indicate that the interaction of PCNA and DNA pol-β contributes to neuronal death in PD.	DisGeNET	Detail
However, susceptibility genes, such as CDKN2BAS (Cyclin Dependend KiNase 2B AntiSense RNA; alias ANR...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
MEG3, HOTAIR, MALAT-1 and proliferating cell nuclear antigen (PCNA) were detected in 52 NFPA samples...	DisGeNET	Detail
Pituitary cyclin E/E2F1 signaling is a previously unappreciated molecular mechanism underlying neuro...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Our results indicated that the downregulation of CFTR in the cystic follicles was accompanied by red...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
The data demonstrated that the expression of P21, cyclin D and phosphorylated retinoblastoma was sig...	DisGeNET	Detail
Cyclin-dependent kinase inhibitors (CDKi) target the retinoblastoma (RB) signaling network, and have...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
In the present study we have mined these two studies for new therapeutic agents for SCLC and identif...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Overexpression of cyclin B has been shown to affect survival in some malignant tumors, including bre...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
RA treatment reduced the expression of several of the investigated genes; the proliferating cell nuc...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell carcinoma transformat...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target for Cushing Disease.	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
In conclusion, the present study reveals that the increased expression of OCT4 is correlated with th...	DisGeNET	Detail
Consistent with this, CST1 mRNA overexpression was correlated closely with malignancy-associated pro...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
These effects may result from the ability of miR-5100 to promote G1/S transition and downregulate cy...	DisGeNET	Detail
Overexpression p21WAF1/CIP1 in suppressing retinal pigment epithelial cells and progression of proli...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
The human DMTF1 (DMP1) transcription factor, a DNA binding protein that interacts with cyclin D, is ...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
COX-2 inhibitor celecoxib also suppressed the proliferative activities of GAC cells with decreased e...	DisGeNET	Detail
NA	DisGeNET	Detail
Downregulation of NF-κB, cyclin D1, cyclin E1, matrix metalloproteinases (MMP)-2, MMP-9, and prolife...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Cyclin D1b overexpression inhibits cell proliferation and induces cell apoptosis in cervical cancer ...	DisGeNET	Detail
Long noncoding RNA CCHE1 promotes cervical cancer cell proliferation via upregulating PCNA.	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Furthermore, PCNA mRNA levels markedly increased in invasive NFPAs compared to non-invasive ones (P ...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Downregulation of NF-κB, cyclin D1, cyclin E1, matrix metalloproteinases (MMP)-2, MMP-9, and prolife...	DisGeNET	Detail
In conclusion, the present study reveals that the increased expression of OCT4 is correlated with th...	DisGeNET	Detail
Consistent with this, CST1 mRNA overexpression was correlated closely with malignancy-associated pro...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Antitumor effects of a novel small molecule targeting PCNA chromatin association in prostate cancer.	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Overexpression of cyclin B has been shown to affect survival in some malignant tumors, including bre...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Overexpression of cyclin B has been shown to affect survival in some malignant tumors, including bre...	DisGeNET	Detail
Doxorubicin (DOX), a broad‑spectrum anthra-cyclin, is in wide clinical use for the treatment and pre...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Overexpression of RASSF5 markedly suppressed cell proliferation and invasion, and induced cell apopt...	DisGeNET	Detail
Inhibition of osteosarcoma cell progression by MacroH2A via the downregulation of cyclin D and cycli...	DisGeNET	Detail
When HMGN2 expression was enhanced, the expression of cyclin D1 and PCNA was downregulated in osteos...	DisGeNET	Detail
Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and Osteosarcoma Cell L...	DisGeNET	Detail
NA	DisGeNET	Detail
Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis.	DisGeNET	Detail
Genetic alteration of cyclin-dependent kinase inhibitors has been associated with carcinogenesis mec...	DisGeNET	Detail
RV-cyclin presents a novel and ancient mechanism of retrovirus-induced oncogenesis.	DisGeNET	Detail
This study was performed to screen cyclin D1 (CCND1) and cyclin dependent kinases (CDK4) genes in or...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Antitumor effects of a novel small molecule targeting PCNA chromatin association in prostate cancer.	DisGeNET	Detail
NA	DisGeNET	Detail
Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and Osteosarcoma Cell L...	DisGeNET	Detail
NA	DisGeNET	Detail
These effects may result from the ability of miR-5100 to promote G1/S transition and downregulate cy...	DisGeNET	Detail
As a consequence, the expression of COX-2 and PCNA was found in cancer tissues with a higher strong ...	DisGeNET	Detail
Cyclin-dependent kinase 8 (CDK8), a gene encoding the cyclin-dependent kinase (CDK) component of the...	DisGeNET	Detail
Knockdown of EGFR reduced cell proliferation and invasion of GC with decreased expression of AKT, PC...	DisGeNET	Detail
Functional analysis studies revealed that ectopic expression of miR-133a reduced cell proliferation ...	DisGeNET	Detail
RNA interference of HMGB3 in UBC cell lines inhibited cancer cell growth and migration, along with t...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Cell growth was inhibited by the overexpression of miR-138, although not by the knockout of Limk1. m...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Further study indicated that most of the genes in the coexpression network were enriched in ECM-rece...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Prognostic value of cyclin B in endometrial endometrioid adenocarcinoma.	DisGeNET	Detail
Cyclin E Expression Correlates with Cancer-specific Survival in Endometrial Endometrioid Adenocarcin...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
RNA interference of HMGB3 in UBC cell lines inhibited cancer cell growth and migration, along with t...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell carcinoma transformat...	DisGeNET	Detail
Overexpression of cyclin B has been shown to affect survival in some malignant tumors, including bre...	DisGeNET	Detail
NA	DisGeNET	Detail
Our results indicate that SNPs in the NER genes ERCC1 (Asn118Asn, 15310G>C, 8902G>T), XPA (-4G...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
The protein expression of PCNA and EGFR was significantly higher in high-grade than low-grade glioma...	DisGeNET	Detail
Silencing ARPP-19 in HCC cells resulted in decreased protein levels of phospho-(Ser) CDKs substrates...	DisGeNET	Detail
Consistent with these results, the expression of SRC-1 was positively correlated with PCNA expressio...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Moreover, these animals exhibited renal inflammation, fibrosis, and increased cyclin E. These result...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Key messages: Cyclin E promoter activity is high in cancer cells and enhanced by adenovirus infectio...	DisGeNET	Detail
Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target for Cushing Disease.	DisGeNET	Detail
NA	DisGeNET	Detail
We have previously found that cyclin E expression is augmented in cancer cells after adenovirus (Ad)...	DisGeNET	Detail
NA	DisGeNET	Detail
RA treatment reduced the expression of several of the investigated genes; the proliferating cell nuc...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Here we report that p57Kip2, a cyclin-dependent kinase (CDK) inhibitor implicated in the development...	DisGeNET	Detail
Cyclin-dependent kinase (CDK)-inhibitor 1C (CDKN1C) negatively regulates cellular proliferation and ...	DisGeNET	Detail
NA	DisGeNET	Detail
RNA interference of HMGB3 in UBC cell lines inhibited cancer cell growth and migration, along with t...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
Cyclin-dependent kinase 8 (CDK8), a gene encoding the cyclin-dependent kinase (CDK) component of the...	DisGeNET	Detail
Overexpression of cyclin B has been shown to affect survival in some malignant tumors, including bre...	DisGeNET	Detail
NA	DisGeNET	Detail
Doxorubicin (DOX), a broad‑spectrum anthra-cyclin, is in wide clinical use for the treatment and pre...	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail
NA	DisGeNET	Detail

Overlapped Transcript Coordinates

Gene	Transcript ID	Exon Number	Chromosome	Start	Stop	Type	Amino Mutation	Transcript Position	Links

Overlapped Transcript

Gene	Transcript ID	Chromosome	Start	Stop	Links

Gene: -
dbSNP: rs386493716 dbSNP
Genome: hg38
Position: chr20:5,114,953-5,126,626
Variant Type: snv

Genome browser