Annotation Detail
Information
- Associated Genes
- PCNA
- Associated Variants
-
PCNA MUTATION
PCNA MUTATION - Associated Disease
- PSEUDOHYPOALDOSTERONISM, TYPE IID
- Source Database
- DisGeNET
- Description
- Moreover, these animals exhibited renal inflammation, fibrosis, and increased cyclin E. These results indicate that FHHt-associated CUL3 Δ403-459 targets KLHL3 for degradation, thereby preventing WNK degradation, whereas general loss of CUL3 activity - while also impairing WNK degradation - has widespread toxic effects in the kidney.
- Pubmed
- 25250572
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 7
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs