chr18:657653:> Detail (hg19)

Information

Genome

Assembly Position
hg19 chr18:657,653-673,578
hg38 chr18:657,653-673,578 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.131 squamous cell carcinoma The gene expression levels of thymidylate synthase were significantly higher in ... BeFree,CTD_human,LHGDN 26031756 Detail
0.002 brain ischemia NA GAD Detail
<0.001 Malignant tumor of cervix NA BeFree Detail
0.003 Uterine Cervical Neoplasm NA LHGDN Detail
0.123 cleft lip NA BeFree,CTD_human,GAD Detail
0.123 cleft palate NA BeFree,CTD_human,GAD Detail
0.140 Colonic Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
0.033 colorectal carcinoma Role of topoisomerase I and thymidylate synthase expression in sporadic colorect... BeFree 24332575 Detail
0.033 colorectal carcinoma Thymidylate synthase genetic polymorphisms and colorectal cancer risk: a meta-an... BeFree 24685603 Detail
0.033 colorectal carcinoma HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal ca... BeFree 25296971 Detail
0.033 colorectal carcinoma Arsenic trioxide (ATO) has been shown to suppress thymidylate synthase (TYMS) in... BeFree 25335113 Detail
0.033 colorectal carcinoma miR-203 enhances chemosensitivity to 5-fluorouracil by targeting thymidylate syn... BeFree 25482885 Detail
0.033 colorectal carcinoma Statistically significant associations were observed between CRC risk and functi... BeFree 26108676 Detail
0.269 Colorectal Neoplasms NA BeFree,CTD_human,GAD,LHGDN,RGD Detail
<0.001 Crohn Disease NA BeFree Detail
<0.001 adenoid cystic carcinoma NA BeFree Detail
0.003 Cytomegalovirus Infections NA BeFree,LHGDN Detail
<0.001 Mental Depression NA BeFree Detail
<0.001 depressive disorder NA BeFree Detail
0.003 diarrhea NA BeFree,GAD Detail
0.120 Digestive System Neoplasms NA CTD_human Detail
0.003 Down syndrome NA BeFree,GAD Detail
0.002 drug allergy NA GAD Detail
0.002 Drug toxicity NA GAD Detail
0.002 Endometrial Neoplasms NA GAD Detail
0.008 Esophageal Neoplasms NA BeFree,GAD,LHGDN Detail
<0.001 Exanthema NA BeFree Detail
<0.001 Fatigue NA BeFree Detail
0.003 Folic Acid Deficiency NA BeFree,GAD Detail
0.002 Gastrointestinal Diseases NA GAD Detail
0.005 Gastrointestinal Neoplasms NA GAD Detail
0.003 glioblastoma NA BeFree,LHGDN Detail
0.120 IgA glomerulonephritis NA CTD_human Detail
0.003 Graft-vs-Host Disease NA BeFree,GAD Detail
0.122 Head and Neck Neoplasms NA CTD_human,GAD Detail
0.003 congenital heart defects NA BeFree,GAD Detail
0.005 Hematological Disease NA GAD Detail
<0.001 Herpes Simplex Infections NA BeFree Detail
<0.001 HIV Infections NA BeFree Detail
0.002 homocystinuria NA GAD Detail
0.002 Hyperplasia NA GAD Detail
<0.001 intestinal obstruction NA BeFree Detail
0.002 Kidney Diseases NA GAD Detail
0.002 Laryngeal neoplasm NA GAD Detail
0.015 leukemia NA BeFree,GAD Detail
0.002 lymphoid leukemia NA GAD Detail
0.004 Acute lymphocytic leukemia NA BeFree Detail
0.003 Leukemia, Myelocytic, Acute NA BeFree,GAD Detail
<0.001 Myeloid Leukemia, Chronic NA BeFree Detail
<0.001 acute promyelocytic leukemia Arsenic trioxide (ATO) has been shown to suppress thymidylate synthase (TYMS) in... BeFree 25335113 Detail
0.003 leukopenia NA BeFree,GAD Detail
<0.001 lipodystrophy NA BeFree Detail
0.003 Liver neoplasms NA BeFree,GAD Detail
0.003 Chronic Obstructive Airway Disease NA BeFree,GAD Detail
0.128 Lung Neoplasms NA CTD_human,GAD,LHGDN Detail
0.002 Lupus Erythematosus, Systemic NA GAD Detail
<0.001 Lymphatic Metastasis NA BeFree Detail
0.011 lymphoma NA BeFree,GAD,LHGDN Detail
0.123 Lymphoma, Follicular NA BeFree,CTD_human,GAD Detail
0.127 Lymphoma, Non-Hodgkin Our study suggests that variation in several OCM genes (CBS, FTHFD, SHMT1, TCN1,... BeFree,CTD_human,GAD 25384508 Detail
<0.001 malaria NA BeFree Detail
0.044 Malignant neoplasm of stomach Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase ... BeFree,GAD 24756984 Detail
0.044 Malignant neoplasm of stomach Raltitrexed is a specific inhibitor of thymidylate synthase (TS), which has been... BeFree,GAD 25109431 Detail
0.044 Malignant neoplasm of stomach Correlation between expression of thymidylate synthase and clinical outcome of a... BeFree,GAD 25185651 Detail
0.044 Malignant neoplasm of stomach These polymorphisms have been related to the risk of suffering different cancers... BeFree,GAD 26166093 Detail
0.080 Mammary Neoplasms, Experimental NA RGD Detail
<0.001 melanoma NA BeFree Detail
0.003 meningioma NA BeFree,LHGDN Detail
<0.001 premature menopause NA BeFree Detail
<0.001 Mesothelioma Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesotheli... BeFree 25335113 Detail
<0.001 Metabolic Diseases The purpose of this study was to investigate if Z-TMS still shows potential for ... BeFree 26044878 Detail
0.002 Metaplasia NA GAD Detail
<0.001 Mixed Salivary Gland Tumor NA BeFree Detail
0.123 cleft lip We investigated two TYMS functional variants (a 28-bp tandem repeat in the promo... BeFree 23404871 Detail
<0.001 Sporadic Breast Carcinoma Genetic variant rs16430 6bp &gt; 0bp at the microRNA-binding site in TYMS and ri... BeFree 24166930 Detail
0.123 cleft palate We investigated two TYMS functional variants (a 28-bp tandem repeat in the promo... BeFree 23404871 Detail
0.002 Mouth Neoplasms NA GAD Detail
0.008 multiple myeloma NA BeFree,GAD Detail
<0.001 Xeroderma Pigmentosum, Complementation Group D The germline polymorphisms studied were thymidylate synthase, (VNTR/5'UTR, 2R G&... BeFree 21570215 Detail
0.008 Neoplasm Metastasis NA BeFree,LHGDN Detail
0.120 Neoplasm Recurrence, Local NA CTD_human Detail
0.120 nervous system disorder NA CTD_human Detail
0.009 Neural Tube Defects NA GAD Detail
0.003 neutropenia NA BeFree,GAD Detail
0.005 Bone necrosis NA GAD Detail
0.003 osteosarcoma NA BeFree,GAD Detail
0.002 ovarian carcinoma Thirteen variants in the pyrimidine metabolism genes, DPYD, DPYS, PPAT, and TYMS... BeFree 25066213 Detail
<0.001 Pustulosis of Palms and Soles NA BeFree Detail
0.125 Pancreatic Neoplasm NA CTD_human,GAD,LHGDN Detail
<0.001 pancreatitis NA BeFree Detail
<0.001 Peripheral neuropathy NA BeFree Detail
0.002 Pharyngeal Neoplasms NA GAD Detail
<0.001 Rothmund-Thomson syndrome NA BeFree Detail
<0.001 polyps NA BeFree Detail
0.123 Prostatic Neoplasms NA CTD_human,LHGDN Detail
0.133 Rectal Neoplasms NA BeFree,CTD_human,GAD Detail
0.003 retinoblastoma NA BeFree,GAD Detail
<0.001 Rett syndrome NA BeFree Detail
0.080 Splenomegaly NA RGD Detail
0.153 Stomach Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 stomatitis NA BeFree Detail
0.002 Cerebrovascular accident NA GAD Detail
<0.001 Giant Cell Arteritis NA BeFree Detail
0.120 Tongue Neoplasms NA CTD_human Detail
0.120 Adverse reaction to drug NA CTD_human Detail
0.002 Venous Thrombosis NA GAD Detail
<0.001 xeroderma pigmentosum NA BeFree Detail
<0.001 Arachnoid Cysts NA BeFree Detail
0.002 Helicobacter Infections NA GAD Detail
0.002 B-Cell Lymphomas NA GAD Detail
0.003 diffuse large B-cell lymphoma NA BeFree,GAD Detail
0.001 Lymphoma, Large-Cell, Follicular NA BeFree Detail
0.003 T-Cell Lymphoma NA BeFree,GAD Detail
0.008 spina bifida NA BeFree,GAD Detail
0.005 Central Nervous System Neoplasms NA GAD Detail
<0.001 Ovarian Failure, Premature NA BeFree Detail
0.002 Arthritis, Reactive NA GAD Detail
<0.001 acute leukemia NA BeFree Detail
<0.001 Squamous cell carcinoma of lung NA BeFree Detail
0.001 Small cell carcinoma of lung NA BeFree Detail
0.005 Migraine Disorders NA BeFree,GAD Detail
0.001 Adenocarcinoma of rectum NA BeFree Detail
0.003 Adenocarcinoma of lung (disorder) Arsenic trioxide (ATO) has been shown to suppress thymidylate synthase (TYMS) in... BeFree 25335113 Detail
<0.001 esophageal carcinoma NA BeFree Detail
<0.001 Malignant neoplasm of nasopharynx NA BeFree Detail
<0.001 Malignant tumor of peritoneum NA BeFree Detail
<0.001 Secondary malignant neoplasm of lung NA BeFree Detail
0.002 Aortic Aneurysm, Abdominal NA GAD Detail
<0.001 Agenesis of corpus callosum NA BeFree Detail
<0.001 Tumor Progression NA BeFree Detail
<0.001 thymic carcinoma NA BeFree Detail
<0.001 adenosquamous carcinoma NA BeFree Detail
<0.001 Adenomatous Polyps NA BeFree Detail
0.003 Carcinoma, Neuroendocrine NA BeFree,LHGDN Detail
0.123 Neuroendocrine Tumors NA BeFree,CTD_human,LHGDN Detail
0.120 Hyperammonemia NA CTD_human Detail
0.002 Neurotoxicity Syndromes NA GAD Detail
0.003 pancreatic carcinoma NA BeFree Detail
<0.001 Cancer of Nasopharynx NA BeFree Detail
<0.001 islet cell tumor NA BeFree Detail
0.016 Malignant neoplasm of lung Diagnostic tissue-samples were used to assess TS-expression by immunohistochemis... BeFree,GAD 25250715 Detail
<0.001 Mucosa-Associated Lymphoid Tissue Lymphoma NA BeFree Detail
<0.001 Carcinoma, Small Cell NA BeFree Detail
<0.001 Turcot syndrome (disorder) NA BeFree Detail
<0.001 Xeroderma Pigmentosum, Complementation Group D NA BeFree Detail
0.002 Hemifacial Spasm NA GAD Detail
<0.001 Stage III Colon Cancer NA BeFree Detail
<0.001 Malignant neoplasm of stomach stage IV NA BeFree Detail
<0.001 Metastatic Renal Cell Cancer NA BeFree Detail
0.001 gastric adenocarcinoma NA BeFree Detail
<0.001 Non-small cell lung cancer metastatic NA BeFree Detail
0.007 Cancer of Head and Neck NA BeFree,GAD Detail
0.001 Squamous cell carcinoma of esophagus NA BeFree Detail
<0.001 Adenocarcinoma Of Esophagus NA BeFree Detail
<0.001 Conventional (Clear Cell) Renal Cell Carcinoma NA BeFree Detail
0.001 Solid tumour 5-Fluorouracil (5-FU), the mainstay of solid tumor chemotherapy over the past 40... BeFree 24434920 Detail
<0.001 stage, rectal cancer NA BeFree Detail
<0.001 Squamous cell carcinoma of oropharynx TYMS-expression in HPV-positive OPC tissues was significantly higher than in HPV... BeFree 25423960 Detail
<0.001 cervix carcinoma NA BeFree Detail
0.002 Inflammatory disease of mucous membrane NA GAD Detail
<0.001 pleomorphic carcinoma The gene expression levels of thymidylate synthase were significantly higher in ... BeFree 26031756 Detail
<0.001 Adenocarcinoma of colon NA BeFree Detail
0.005 Malignant neoplasm of pancreas NA BeFree,GAD Detail
<0.001 intracranial meningioma NA BeFree Detail
<0.001 Malignant neoplasm of prostate NA BeFree Detail
<0.001 Hematologic Neoplasms NA BeFree Detail
<0.001 endometrial carcinoma NA BeFree Detail
0.004 Secondary malignant neoplasm of liver NA BeFree Detail
0.002 dementia NA GAD Detail
<0.001 Recurrent tumor NA BeFree Detail
0.002 Retinal Neoplasms NA GAD Detail
0.024 Malignant neoplasm of esophagus NA BeFree,GAD Detail
0.005 Methotrexate poisoning NA GAD Detail
0.002 Carcinogenesis The role of folic acid in carcinogenesis may be modulated by polymorphism C677T ... BeFree 25341694 Detail
<0.001 Islets of Langerhans hyperplasia NA BeFree Detail
0.005 hyperhomocysteinemia NA BeFree,GAD Detail
<0.001 prostate carcinoma NA BeFree Detail
0.002 Epithelial ovarian cancer Thirteen variants in the pyrimidine metabolism genes, DPYD, DPYS, PPAT, and TYMS... BeFree 25066213 Detail
<0.001 Progressive Neoplastic Disease NA BeFree Detail
<0.001 Refractory cancer Since high levels of TS have been linked to clinical resistance to pemetrexed in... BeFree 25301686 Detail
<0.001 Locally Advanced Malignant Neoplasm NA BeFree Detail
0.007 breast carcinoma Association between polymorphisms in the thymidylate synthase gene and risk of b... BeFree 25366766 Detail
0.007 breast carcinoma A number of these SNPs, specifically in genes including MTR, MTRR, SHMT1, TYMS a... BeFree 25598430 Detail
0.004 Carcinoma of lung Diagnostic tissue-samples were used to assess TS-expression by immunohistochemis... BeFree 25250715 Detail
0.003 Malignant neoplasm of gastrointestinal tract NA BeFree Detail
0.002 Secondary malignant neoplasm of lymph node NA BeFree Detail
0.002 Pregnancy loss NA GAD Detail
0.013 colon carcinoma Gossypol sensitizes the antitumor activity of 5-FU through down-regulation of th... BeFree 26208739 Detail
0.014 stomach carcinoma Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase ... BeFree 24756984 Detail
0.014 stomach carcinoma Raltitrexed is a specific inhibitor of thymidylate synthase (TS), which has been... BeFree 25109431 Detail
0.014 stomach carcinoma Correlation between expression of thymidylate synthase and clinical outcome of a... BeFree 25185651 Detail
0.014 stomach carcinoma These polymorphisms have been related to the risk of suffering different cancers... BeFree 26166093 Detail
0.001 Carcinoma of bladder NA BeFree Detail
<0.001 Malignant neoplasm of kidney NA BeFree Detail
<0.001 adult acute lymphocytic leukemia NA BeFree Detail
0.001 malignant pleural mesothelioma NA BeFree Detail
<0.001 Myelosuppression NA BeFree Detail
<0.001 Colorectal cancer recurrent NA BeFree Detail
<0.001 Adenocarcinoma of lung, stage I NA BeFree Detail
<0.001 Acute GVH disease NA BeFree Detail
<0.001 Advanced cancer NA BeFree Detail
0.123 ovarian neoplasm NA CTD_human,LHGDN Detail
<0.001 cancer recurrence NA BeFree Detail
<0.001 cancer regression NA BeFree Detail
0.007 breast carcinoma In this case-control study, we investigated the association between MTHFR C677T ... BeFree 22134752 Detail
<0.001 Bone marrow toxicity NA BeFree Detail
0.004 Colorectal cancer metastatic We previously reported that the clinical response and prognosis of metastatic co... BeFree 25198900 Detail
0.004 Colorectal cancer metastatic The TYMS 2R/3G, 3C/3G or 3G/3G promoter variants were associated with worse PFS ... BeFree 25677447 Detail
0.004 Acute lymphocytic leukemia Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C142... BeFree 22838948 Detail
<0.001 neuroblastoma The aim of this study was to investigate whether the genetic polymorphisms MTHFR... BeFree 24771227 Detail
<0.001 Vascular occlusion NA BeFree Detail
<0.001 Gastrooesophageal cancer Germline polymorphisms of DPYD, TYMS and GSTP1 have a significant effect on toxi... BeFree 25677447 Detail
0.022 Precursor Cell Lymphoblastic Leukemia Lymphoma Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C142... BeFree 22838948 Detail
0.003 retinoblastoma A case-control study of 72 retinoblastoma cases and 98 cancer-free children cont... BeFree 20310006 Detail
0.004 Malignant neoplasm of ovary NA BeFree,GAD Detail
<0.001 Central neuroblastoma The aim of this study was to investigate whether the genetic polymorphisms MTHFR... BeFree 24771227 Detail
0.035 Malignant neoplasm of breast In this case-control study, we investigated the association between MTHFR C677T ... BeFree 22134752 Detail
<0.001 Stage IV Pancreatic Cancer NA BeFree Detail
0.001 Squamous cell carcinoma of the head and neck NA BeFree Detail
<0.001 sarcoma NA BeFree Detail
0.004 Adenoma of large intestine NA BeFree,GAD Detail
0.002 Adenocarcinoma of large intestine NA BeFree Detail
<0.001 Thymoma, type C NA BeFree Detail
<0.001 gastric cardia adenocarcinoma NA BeFree Detail
<0.001 Sporadic Breast Carcinoma Genetic variant rs16430 6bp > 0bp at the microRNA-binding site in TYMS and risk ... BeFree 24166930 Detail
<0.001 Marginal Zone B-Cell Lymphoma NA BeFree Detail
<0.001 Epithelioma NA BeFree Detail
<0.001 renal carcinoma NA BeFree Detail
<0.001 Metastatic Carcinoma We have designed four gene molecular beacon (MB) probes for multiplex quantitati... BeFree 24935362 Detail
0.136 Mammary Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 Xenograft Model NA BeFree Detail
0.112 colorectal cancer Role of topoisomerase I and thymidylate synthase expression in sporadic colorect... BeFree,GAD 24332575 Detail
0.112 colorectal cancer Thymidylate synthase genetic polymorphisms and colorectal cancer risk: a meta-an... BeFree,GAD 24685603 Detail
0.112 colorectal cancer HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal ca... BeFree,GAD 25296971 Detail
0.112 colorectal cancer Arsenic trioxide (ATO) has been shown to suppress thymidylate synthase (TYMS) in... BeFree,GAD 25335113 Detail
0.112 colorectal cancer miR-203 enhances chemosensitivity to 5-fluorouracil by targeting thymidylate syn... BeFree,GAD 25482885 Detail
0.112 colorectal cancer Statistically significant associations were observed between CRC risk and functi... BeFree,GAD 26108676 Detail
<0.001 Rectal Tumors NA BeFree Detail
0.002 Rash and Dermatitis Adverse Event Associated with Chemoradiation NA BeFree Detail
<0.001 Glioblastoma multiforme NA BeFree Detail
<0.001 uterine corpus cancer NA BeFree Detail
0.003 coronary artery disease NA BeFree,GAD Detail
0.022 Precursor Cell Lymphoblastic Leukemia Lymphoma NA BeFree,GAD,LHGDN Detail
0.129 liver carcinoma NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 Nasopharyngeal carcinoma NA BeFree Detail
0.003 Prostatic Hyperplasia NA LHGDN Detail
<0.001 Stage III Colon Cancer AJCC v7 NA BeFree Detail
<0.001 Progressive cGVHD NA BeFree Detail
<0.001 Thymus Neoplasms NA BeFree Detail
0.005 Spontaneous abortion NA GAD,LHGDN Detail
<0.001 acute pancreatitis NA BeFree Detail
0.031 adenocarcinoma The gene expression levels of thymidylate synthase were significantly higher in ... BeFree,GAD,LHGDN 26031756 Detail
0.003 adenoma NA BeFree,GAD Detail
0.121 anemia NA BeFree,CTD_human Detail
0.026 rheumatoid arthritis Therapeutic outcome of rheumatoid arthritis (RA) patients treated with methotrex... BeFree,GAD,LHGDN 25279663 Detail
0.002 Barrett esophagus NA GAD Detail
0.003 Behcet Syndrome NA BeFree,GAD Detail
0.008 Malignant neoplasm of urinary bladder NA BeFree,GAD Detail
0.080 Bladder Neoplasm NA BeFree,RGD Detail
0.002 Bone neoplasms NA GAD Detail
0.120 Brain Diseases NA CTD_human Detail
0.035 Malignant neoplasm of breast Association between polymorphisms in the thymidylate synthase gene and risk of b... BeFree,GAD 25366766 Detail
0.035 Malignant neoplasm of breast A number of these SNPs, specifically in genes including MTR, MTRR, SHMT1, TYMS a... BeFree,GAD 25598430 Detail
0.014 Malignant tumor of colon NA BeFree,GAD Detail
<0.001 Malignant neoplasm of endometrium NA BeFree Detail
0.007 Rectal Carcinoma NA BeFree,GAD Detail
0.013 Non-small cell lung carcinoma In addition, relationships between EGFR mutation status and the immunohistochemi... BeFree,GAD 24405586 Detail
0.013 Non-small cell lung carcinoma Seventy-six Chinese patients with NSCLC were enrolled in the study to investigat... BeFree,GAD 24762590 Detail
0.013 Non-small cell lung carcinoma This study was aimed to establish a novel method to simultaneously detect expres... BeFree,GAD 24935362 Detail
0.013 Non-small cell lung carcinoma Since high levels of TS have been linked to clinical resistance to pemetrexed in... BeFree,GAD 25301686 Detail
<0.001 renal cell carcinoma NA BeFree Detail
Annotation

Annotations

DescrptionSourceLinks
The gene expression levels of thymidylate synthase were significantly higher in PPC and SCC as compa... DisGeNET Detail
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Role of topoisomerase I and thymidylate synthase expression in sporadic colorectal cancer: associati... DisGeNET Detail
Thymidylate synthase genetic polymorphisms and colorectal cancer risk: a meta-analysis. DisGeNET Detail
HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to t... DisGeNET Detail
Arsenic trioxide (ATO) has been shown to suppress thymidylate synthase (TYMS) in lung adenocarcinoma... DisGeNET Detail
miR-203 enhances chemosensitivity to 5-fluorouracil by targeting thymidylate synthase in colorectal ... DisGeNET Detail
Statistically significant associations were observed between CRC risk and functionally defined candi... DisGeNET Detail
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Arsenic trioxide (ATO) has been shown to suppress thymidylate synthase (TYMS) in lung adenocarcinoma... DisGeNET Detail
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Our study suggests that variation in several OCM genes (CBS, FTHFD, SHMT1, TCN1, and TYMS) may influ... DisGeNET Detail
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Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase gene predict risk an... DisGeNET Detail
Raltitrexed is a specific inhibitor of thymidylate synthase (TS), which has been considered as a pot... DisGeNET Detail
Correlation between expression of thymidylate synthase and clinical outcome of advanced gastric canc... DisGeNET Detail
These polymorphisms have been related to the risk of suffering different cancers, for example leukem... DisGeNET Detail
NA DisGeNET Detail
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Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma. DisGeNET Detail
The purpose of this study was to investigate if Z-TMS still shows potential for the prevention of me... DisGeNET Detail
NA DisGeNET Detail
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We investigated two TYMS functional variants (a 28-bp tandem repeat in the promoter enhancer region ... DisGeNET Detail
Genetic variant rs16430 6bp &gt; 0bp at the microRNA-binding site in TYMS and risk of sporadic breas... DisGeNET Detail
We investigated two TYMS functional variants (a 28-bp tandem repeat in the promoter enhancer region ... DisGeNET Detail
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The germline polymorphisms studied were thymidylate synthase, (VNTR/5'UTR, 2R G&gt;C single nucleoti... DisGeNET Detail
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Thirteen variants in the pyrimidine metabolism genes, DPYD, DPYS, PPAT, and TYMS, also interacted si... DisGeNET Detail
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Arsenic trioxide (ATO) has been shown to suppress thymidylate synthase (TYMS) in lung adenocarcinoma... DisGeNET Detail
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Diagnostic tissue-samples were used to assess TS-expression by immunohistochemistry (IHC) and mRNA-e... DisGeNET Detail
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5-Fluorouracil (5-FU), the mainstay of solid tumor chemotherapy over the past 40 years, induces grad... DisGeNET Detail
NA DisGeNET Detail
TYMS-expression in HPV-positive OPC tissues was significantly higher than in HPV-negative ones in bo... DisGeNET Detail
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The gene expression levels of thymidylate synthase were significantly higher in PPC and SCC as compa... DisGeNET Detail
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The role of folic acid in carcinogenesis may be modulated by polymorphism C677T in MTHFR and tandem ... DisGeNET Detail
NA DisGeNET Detail
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Thirteen variants in the pyrimidine metabolism genes, DPYD, DPYS, PPAT, and TYMS, also interacted si... DisGeNET Detail
NA DisGeNET Detail
Since high levels of TS have been linked to clinical resistance to pemetrexed in NSCLC, herein we in... DisGeNET Detail
NA DisGeNET Detail
Association between polymorphisms in the thymidylate synthase gene and risk of breast cancer in a Me... DisGeNET Detail
A number of these SNPs, specifically in genes including MTR, MTRR, SHMT1, TYMS and SLC19A1, were ass... DisGeNET Detail
Diagnostic tissue-samples were used to assess TS-expression by immunohistochemistry (IHC) and mRNA-e... DisGeNET Detail
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Gossypol sensitizes the antitumor activity of 5-FU through down-regulation of thymidylate synthase i... DisGeNET Detail
Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase gene predict risk an... DisGeNET Detail
Raltitrexed is a specific inhibitor of thymidylate synthase (TS), which has been considered as a pot... DisGeNET Detail
Correlation between expression of thymidylate synthase and clinical outcome of advanced gastric canc... DisGeNET Detail
These polymorphisms have been related to the risk of suffering different cancers, for example leukem... DisGeNET Detail
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In this case-control study, we investigated the association between MTHFR C677T and A1298C, TYMS 5'-... DisGeNET Detail
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We previously reported that the clinical response and prognosis of metastatic colorectal cancer (mCR... DisGeNET Detail
The TYMS 2R/3G, 3C/3G or 3G/3G promoter variants were associated with worse PFS in the CRC (HR = 2.0... DisGeNET Detail
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R... DisGeNET Detail
The aim of this study was to investigate whether the genetic polymorphisms MTHFR C677T and A1298C, M... DisGeNET Detail
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Germline polymorphisms of DPYD, TYMS and GSTP1 have a significant effect on toxicity and clinical ou... DisGeNET Detail
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R... DisGeNET Detail
A case-control study of 72 retinoblastoma cases and 98 cancer-free children controls was performed t... DisGeNET Detail
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The aim of this study was to investigate whether the genetic polymorphisms MTHFR C677T and A1298C, M... DisGeNET Detail
In this case-control study, we investigated the association between MTHFR C677T and A1298C, TYMS 5'-... DisGeNET Detail
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Genetic variant rs16430 6bp > 0bp at the microRNA-binding site in TYMS and risk of sporadic breast c... DisGeNET Detail
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We have designed four gene molecular beacon (MB) probes for multiplex quantitative real-time polymer... DisGeNET Detail
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Role of topoisomerase I and thymidylate synthase expression in sporadic colorectal cancer: associati... DisGeNET Detail
Thymidylate synthase genetic polymorphisms and colorectal cancer risk: a meta-analysis. DisGeNET Detail
HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to t... DisGeNET Detail
Arsenic trioxide (ATO) has been shown to suppress thymidylate synthase (TYMS) in lung adenocarcinoma... DisGeNET Detail
miR-203 enhances chemosensitivity to 5-fluorouracil by targeting thymidylate synthase in colorectal ... DisGeNET Detail
Statistically significant associations were observed between CRC risk and functionally defined candi... DisGeNET Detail
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The gene expression levels of thymidylate synthase were significantly higher in PPC and SCC as compa... DisGeNET Detail
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Therapeutic outcome of rheumatoid arthritis (RA) patients treated with methotrexate (MTX) can be mod... DisGeNET Detail
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Association between polymorphisms in the thymidylate synthase gene and risk of breast cancer in a Me... DisGeNET Detail
A number of these SNPs, specifically in genes including MTR, MTRR, SHMT1, TYMS and SLC19A1, were ass... DisGeNET Detail
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In addition, relationships between EGFR mutation status and the immunohistochemical expression of DP... DisGeNET Detail
Seventy-six Chinese patients with NSCLC were enrolled in the study to investigate mRNA expression pr... DisGeNET Detail
This study was aimed to establish a novel method to simultaneously detect expression of four genes, ... DisGeNET Detail
Since high levels of TS have been linked to clinical resistance to pemetrexed in NSCLC, herein we in... DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs16430 dbSNP
Genome
hg19
Position
chr18:657,653-673,578
Variant Type
snv
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