chr6:31575254:G>A Detail (hg38) (TNF)

Information

Genome

Assembly Position
hg19 chr6:31,543,031-31,543,031 View the variant detail on this assembly version.
hg38 chr6:31,575,254-31,575,254

HGVS

[No Data.]
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

JP HGVD:[No Data.]
ToMMo:0.010
NCBN:[No Data.]
NCBN(Hondo):[No Data.]
NCBN(Ryukyu):[No Data.]
East asia ExAC:0.166

Prediction

ClinVar

Clinical Significance drug response
Review star
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
Clinical significance Last evaluated Review status Condition Origin Links
drug response 2021-03-24 reviewed by expert panel germline Detail
Uncertain significance 2021-02-09 no assertion criteria provided Susceptibility to severe coronavirus disease (COVID-19) germline Detail
risk factor 2006-03-01 no assertion criteria provided Systemic lupus erythematosus, susceptibility to germline Detail
risk factor 2006-03-01 no assertion criteria provided Inherited susceptibility to asthma germline Detail
risk factor 2006-03-01 no assertion criteria provided Malaria, cerebral, susceptibility to germline Detail
risk factor 2006-03-01 no assertion criteria provided Septic shock, susceptibility to germline Detail
risk factor 2006-03-01 no assertion criteria provided Human immunodeficiency virus dementia, susceptibility to germline Detail
risk factor 2006-03-01 no assertion criteria provided Migraine without aura, susceptibility to germline Detail
risk factor 2006-03-01 no assertion criteria provided Psoriatic arthritis, susceptibility to germline Detail
Affects 2021-10-20 no assertion criteria provided endometriosis somatic Detail
Uncertain significance 2021-08-07 no assertion criteria provided Susceptibility to severe coronavirus disease (COVID-19) due to high plasma levels of TNF, TNFR, and/or TNFR4 germline Detail
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.266 asthma GSTP1 rs1138272 and TNF rs1800629 SNPs were associated with asthma and wheeze, r... BeFree 24465030 Detail
0.002 Wheezing GSTP1 rs1138272 and TNF rs1800629 SNPs were associated with asthma and wheeze, r... BeFree 24465030 Detail
0.002 Wheezing GSTP1 rs1138272 and TNF rs1800629 SNPs were associated with asthma and wheeze, r... BeFree 24465030 Detail
0.003 Migraine Disorders In this study, the association of the occurrence and clinical characteristics of... BeFree 20113413 Detail
0.139 Migraine Disorders In this study, the association of the occurrence and clinical characteristics of... BeFree 20113413 Detail
0.001 vascular disease occlusive All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... BeFree 23107763 Detail
0.337 hyperhomocysteinemia All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... BeFree 23107763 Detail
<0.001 Septicaemia due to gram-negative organism, unspecified Genotype AG of rs1800629 (the LTA gene) and genotypes CC and CT of rs1341023 (th... BeFree 25000179 Detail
<0.001 hyperhomocysteinemia All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... BeFree 23107763 Detail
0.055 asthma To investigate associations between total serum immunoglobulin E (IgE) levels an... BeFree 22376040 Detail
0.038 asthma To investigate associations between total serum immunoglobulin E (IgE) levels an... BeFree 22376040 Detail
0.266 asthma To investigate associations between total serum immunoglobulin E (IgE) levels an... BeFree 22376040 Detail
0.146 Homocysteinemia All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... BeFree 23107763 Detail
<0.001 Homocysteinemia All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... BeFree 23107763 Detail
0.006 Cervical Intraepithelial Neoplasia When compared to controls, the CIN patients showed increased frequencies of CC (... BeFree 23363891 Detail
0.005 gastric adenocarcinoma To investigate the potential association between five cytokine promoter polymorp... BeFree 22891178 Detail
0.001 epilepsy To understand the role of genes encoding pro-inflammatory cytokines in epilepsy,... BeFree 22578659 Detail
<0.001 craniosynostosis To replicate and extend recent findings in a Turkish population of associations ... BeFree 20157068 Detail
0.026 multiple sclerosis Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, inclu... BeFree 21621860 Detail
0.001 gastric adenocarcinoma To investigate the potential association between five cytokine promoter polymorp... BeFree 22891178 Detail
<0.001 Chronic sinusitis To replicate and extend recent findings in a Turkish population of associations ... BeFree 20157068 Detail
<0.001 gastric adenocarcinoma To investigate the potential association between five cytokine promoter polymorp... BeFree 22891178 Detail
0.008 Nasal Polyps To replicate and extend recent findings in a Turkish population of associations ... BeFree 20157068 Detail
0.002 epilepsy To understand the role of genes encoding pro-inflammatory cytokines in epilepsy,... BeFree 22578659 Detail
0.082 Seizures To understand the role of genes encoding pro-inflammatory cytokines in epilepsy,... BeFree 22578659 Detail
<0.001 craniosynostosis To replicate and extend recent findings in a Turkish population of associations ... BeFree 20157068 Detail
0.010 Nasal Polyps To replicate and extend recent findings in a Turkish population of associations ... BeFree 20157068 Detail
0.204 Seizures To understand the role of genes encoding pro-inflammatory cytokines in epilepsy,... BeFree 22578659 Detail
0.002 gastric adenocarcinoma To investigate the potential association between five cytokine promoter polymorp... BeFree 22891178 Detail
0.001 Depressive Symptoms The aim of the present study was to investigate a trio of functional SNPs in the... BeFree 25596176 Detail
0.121 Seizures To understand the role of genes encoding pro-inflammatory cytokines in epilepsy,... BeFree 22578659 Detail
0.013 multiple sclerosis Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, inclu... BeFree 21621860 Detail
<0.001 Chronic sinusitis To replicate and extend recent findings in a Turkish population of associations ... BeFree 20157068 Detail
<0.001 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site The following study populations were genotyped for 4 polymorphisms within TNF-be... BeFree 18811622 Detail
0.012 Malignant neoplasm of ovary We examined associations between six TNF single nucleotide polymorphisms (SNPs) ... BeFree 18196539 Detail
<0.001 bronchiolitis The following study populations were genotyped for 4 polymorphisms within TNF-be... BeFree 18811622 Detail
0.050 Lymphoma, Non-Hodgkin A haplotype comprising SNPs in two proinflammatory cytokines, tumor necrosis fac... BeFree 17018637 Detail
0.026 Lymphoma, Non-Hodgkin A haplotype comprising SNPs in two proinflammatory cytokines, tumor necrosis fac... BeFree 17018637 Detail
0.440 Alzheimer's disease Two SNPs, rs1799724 (-850C&gt;T; NT_007592.14:g.22400733C&gt;T) and rs1800629 (-... BeFree 15895461 Detail
0.049 asthma The following study populations were genotyped for 4 polymorphisms within TNF-be... BeFree 18811622 Detail
0.012 ovarian carcinoma We examined associations between six TNF single nucleotide polymorphisms (SNPs) ... BeFree 18196539 Detail
0.024 diabetic retinopathy In a case-control study, the -238G&gt;A (rs361525), -308G&gt;A (rs1800629), and ... BeFree 25634985 Detail
<0.001 migraine with aura Among active migraine with aura, the odds ratios (95% confidence intervals) were... BeFree 19559392 Detail
<0.001 migraine with aura Among active migraine with aura, the odds ratios (95% confidence intervals) were... BeFree 19559392 Detail
<0.001 Common Migraine Among active migraine with aura, the odds ratios (95% confidence intervals) were... BeFree 19559392 Detail
<0.001 migraine with aura Among active migraine with aura, the odds ratios (95% confidence intervals) were... BeFree 19559392 Detail
0.009 Common Migraine Among active migraine with aura, the odds ratios (95% confidence intervals) were... BeFree 19559392 Detail
<0.001 migraine with aura Among active migraine with aura, the odds ratios (95% confidence intervals) were... BeFree 19559392 Detail
<0.001 Common Migraine Among active migraine with aura, the odds ratios (95% confidence intervals) were... BeFree 19559392 Detail
<0.001 migraine with aura Among active migraine with aura, the odds ratios (95% confidence intervals) were... BeFree 19559392 Detail
<0.001 Common Migraine Among active migraine with aura, the odds ratios (95% confidence intervals) were... BeFree 19559392 Detail
<0.001 Common Migraine Among active migraine with aura, the odds ratios (95% confidence intervals) were... BeFree 19559392 Detail
0.017 Peptic Ulcer TNFA-308G&gt;A (rs1800629) and TNFA-1031T&gt;C (rs1799964), which are responsibl... BeFree 25368751 Detail
0.007 Dengue Fever Presence of combination of HLA-DRB1*07/*15 with either rs1799964 'C/C' genotype ... BeFree 23380141 Detail
0.316 Diabetes Mellitus, Non-Insulin-Dependent [The rs1800629 SNP in TNF interacted with the 1-year change in moderate-to-vigor... GAD 20361391 Detail
0.018 osteoporosis We evaluated the association between a G-308A polymorphism (rs1800629) at the TN... BeFree 15797957 Detail
0.204 rheumatoid arthritis In this regard, besides a strong association between the HLA-DRB1∗04 shared epit... BeFree 22927710 Detail
0.032 rheumatoid arthritis In this regard, besides a strong association between the HLA-DRB1∗04 shared epit... BeFree 22927710 Detail
0.179 schizophrenia Lack of association between TNFα rs1800629 polymorphism and schizophrenia risk: ... BeFree 23453739 Detail
0.038 diabetes mellitus We assessed whether rs1800629 and rs1800795 modified the effect of moderate-to-v... BeFree 20361391 Detail
<0.001 breast carcinoma To explore the association of NFKB1 c.-798_-795delATTG (rs28362491), NFKBIA c.-9... BeFree 25559835 Detail
0.026 Lymphoma, Non-Hodgkin Two single nucleotide polymorphisms (SNPs) in adjacent genes, lymphotoxin alpha ... BeFree 19654554 Detail
0.050 Lymphoma, Non-Hodgkin TNF rs1800629 was associated with risk of NHL (OR 1.53, 95% confidence interval,... BeFree 20087644 Detail
0.019 cervix carcinoma Subgroup analysis by the types of cervical lesions showed that there was a signi... BeFree 24015171 Detail
0.002 T-Cell Lymphoma TNF rs1800629 was associated with risk of NHL (OR 1.53, 95% confidence interval,... BeFree 20087644 Detail
0.015 Sleep Apnea, Obstructive Only TNFA rs1800629 was significantly associated with OSA under an allele freque... BeFree 22043116 Detail
0.003 gestational diabetes Our study aimed to assess in vitro production of IL-10, IL-6, TNF-A, and adipone... BeFree 22070425 Detail
0.010 B-Cell Lymphomas TNF rs1800629, which was genotyped in only two of our studies, was also associat... BeFree 23640160 Detail
0.039 diabetes mellitus The rs1800629 polymorphism in the TNF gene interacts with physical activity on t... BeFree 20361391 Detail
0.026 diabetes mellitus The rs1800629 polymorphism in the TNF gene interacts with physical activity on t... BeFree 20361391 Detail
0.050 Lymphoma, Non-Hodgkin Two single nucleotide polymorphisms (SNPs) in adjacent genes, lymphotoxin alpha ... BeFree 19654554 Detail
0.003 Leukemia, Lymphocytic, Acute, L1 TNF-α SNP rs1800629 and risk of relapse in childhood acute lymphoblastic leukemi... BeFree 24798719 Detail
<0.001 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse TNF rs1800629 was associated with risk of NHL (OR 1.53, 95% confidence interval,... BeFree 20087644 Detail
0.425 rheumatoid arthritis TNFA -308 (rs1800629) polymorphism is associated with a higher risk of cardiovas... BeFree 21420089 Detail
0.016 Nasal Polyps The frequency of the A allele in a SNP located in tumor necrosis factor (TNF)-al... BeFree 19405090 Detail
0.011 Diabetes The rs1800629 polymorphism in the TNF gene interacts with physical activity on t... BeFree 20361391 Detail
<0.001 B-Cell Lymphomas Statistically significant interactions with blood transfusion were observed for ... BeFree 22649007 Detail
0.011 Diabetes We assessed whether rs1800629 and rs1800795 modified the effect of moderate-to-v... BeFree 20361391 Detail
0.010 B-Cell Lymphomas Statistically significant interactions with blood transfusion were observed for ... BeFree 22649007 Detail
0.003 Malignant neoplasm of breast To explore the association of NFKB1 c.-798_-795delATTG (rs28362491), NFKBIA c.-9... BeFree 25559835 Detail
<0.001 HIV Infections Two single nucleotide polymorphisms (SNPs) in adjacent genes, lymphotoxin alpha ... BeFree 19654554 Detail
0.019 cervix carcinoma The aim of this study was to investigate the relationship between the TNF-alpha ... BeFree 23028877 Detail
0.425 rheumatoid arthritis In this regard, besides a strong association between the HLA-DRB1∗04 shared epit... BeFree 22927710 Detail
0.187 psoriasis Association of the tumour necrosis factor-α polymorphisms rs361525 and rs1800629... BeFree 24252077 Detail
0.360 rheumatoid arthritis In this regard, besides a strong association between the HLA-DRB1∗04 shared epit... BeFree 22927710 Detail
<0.001 candidiasis Single-nucleotide polymorphisms in three innate immune genes were associated wit... BeFree 24557424 Detail
0.026 gestational diabetes Our study aimed to assess in vitro production of IL-10, IL-6, TNF-A, and adipone... BeFree 22070425 Detail
0.008 diffuse large B-cell lymphoma Variants in TNFα (rs1800629) (GG vs. AG/AA, p &lt; 0.001) and LTA (rs909253) (AA... BeFree 23391141 Detail
<0.001 gestational diabetes Our study aimed to assess in vitro production of IL-10, IL-6, TNF-A, and adipone... BeFree 22070425 Detail
<0.001 Precursor B-cell lymphoblastic leukemia The presence of at least one A allele in TNF-α SNP rs1800629 should suggest a cl... BeFree 24798719 Detail
0.044 Cardiovascular Diseases TNFA -308 (rs1800629) polymorphism is associated with a higher risk of cardiovas... BeFree 21420089 Detail
0.006 diffuse large B-cell lymphoma Variants in TNFα (rs1800629) (GG vs. AG/AA, p &lt; 0.001) and LTA (rs909253) (AA... BeFree 23391141 Detail
0.008 diffuse large B-cell lymphoma TNF rs1800629, which was genotyped in only two of our studies, was also associat... BeFree 23640160 Detail
0.006 diffuse large B-cell lymphoma Variants in TNFα (rs1800629) (GG vs. AG/AA, p &lt; 0.001) and LTA (rs909253) (AA... BeFree 23391141 Detail
0.047 periodontitis We found a strong association only between TNF rs1800629 and diffused forms of p... BeFree 21846573 Detail
0.004 Lymphoma, Large-Cell, Follicular TNF rs1800629 was associated with risk of NHL (OR 1.53, 95% confidence interval,... BeFree 20087644 Detail
0.025 Kidney Diseases The TNFA rs1800629 gene polymorphism is associated with markers of kidney diseas... BeFree 23796916 Detail
0.266 asthma Association between tumor necrosis factor-α rs1800629 polymorphism and risk of a... BeFree 24936650 Detail
<0.001 Classical Hodgkin's Lymphoma We investigated whether selected germline SNPs in IL10 (rs1800890, rs1800896, rs... BeFree 24008079 Detail
0.006 Allergic rhinitis (disorder) Children carrying a minor rs1800629 (TNF) or rs1927911 (TLR4) allele may be at a... BeFree 23639307 Detail
<0.001 Endothelial dysfunction In this regard, besides a strong association between the HLA-DRB1∗04 shared epit... BeFree 22927710 Detail
0.013 Diabetes The rs1800629 polymorphism in the TNF gene interacts with physical activity on t... BeFree 20361391 Detail
0.007 Malignant tumor of cervix Subgroup analysis by the types of cervical lesions showed that there was a signi... BeFree 24015171 Detail
0.007 Malignant tumor of cervix The aim of this study was to investigate the relationship between the TNF-alpha ... BeFree 23028877 Detail
0.019 stomach carcinoma Association between tumor necrosis factor-α rs1800629 polymorphism and risk of g... BeFree 24142527 Detail
0.015 Carcinogenesis There are inconclusive data on the tumor necrosis factor-α (TNF-α) -308 G/A (rs1... BeFree 25614219 Detail
0.010 Overweight [The rs1800629 SNP in TNF interacted with the 1-year change in moderate-to-vigor... GAD 20361391 Detail
0.003 exfoliation syndrome The purpose of the present study was to investigate a hypothesized association b... BeFree 19279689 Detail
0.034 Malignant neoplasm of stomach Association between tumor necrosis factor-α rs1800629 polymorphism and risk of g... BeFree 24142527 Detail
<0.001 Classical Hodgkin's Lymphoma We investigated whether selected germline SNPs in IL10 (rs1800890, rs1800896, rs... BeFree 24008079 Detail
<0.001 Classical Hodgkin's Lymphoma We investigated whether selected germline SNPs in IL10 (rs1800890, rs1800896, rs... BeFree 24008079 Detail
0.004 Impaired glucose tolerance [The rs1800629 SNP in TNF interacted with the 1-year change in moderate-to-vigor... GAD 20361391 Detail
0.012 ulcerative colitis The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL... BeFree 24971461 Detail
0.008 ulcerative colitis The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL... BeFree 24971461 Detail
0.183 Crohn Disease The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL... BeFree 24971461 Detail
0.009 ulcerative colitis The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL... BeFree 24971461 Detail
0.013 ulcerative colitis The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL... BeFree 24971461 Detail
0.009 Crohn Disease The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL... BeFree 24971461 Detail
<0.001 ulcerative colitis The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL... BeFree 24971461 Detail
0.327 ulcerative colitis The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL... BeFree 24971461 Detail
0.001 ulcerative colitis The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL... BeFree 24971461 Detail
0.009 ulcerative colitis The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL... BeFree 24971461 Detail
0.131 ulcerative colitis The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL... BeFree 24971461 Detail
0.126 Crohn Disease The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL... BeFree 24971461 Detail
0.295 ulcerative colitis The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL... BeFree 24971461 Detail
0.034 ulcerative colitis The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL... BeFree 24971461 Detail
<0.001 ulcerative colitis The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL... BeFree 24971461 Detail
0.187 ulcerative colitis The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL... BeFree 24971461 Detail
0.031 Diabetes Mellitus, Non-Insulin-Dependent Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs36152... BeFree 20177654 Detail
0.022 Metabolic syndrome X Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs36152... BeFree 20177654 Detail
0.009 Metabolic syndrome X Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs36152... BeFree 20177654 Detail
<0.001 5,10-Methylenetetrahydrofolate reductase deficiency With the aim to conclusively validate the strongest associations so far reported... BeFree 24521996 Detail
<0.001 5,10-Methylenetetrahydrofolate reductase deficiency With the aim to conclusively validate the strongest associations so far reported... BeFree 24521996 Detail
<0.001 5,10-Methylenetetrahydrofolate reductase deficiency With the aim to conclusively validate the strongest associations so far reported... BeFree 24521996 Detail
Annotation

Annotations

DescrptionSourceLinks
NM_000594.3(TNF):c.-488G>A AND etanercept response - Efficacy ClinVar Detail
NM_000594.3(TNF):c.-488G>A AND Susceptibility to severe coronavirus disease (COVID-19) ClinVar Detail
NM_000594.3(TNF):c.-488G>A AND Systemic lupus erythematosus, susceptibility to ClinVar Detail
NM_000594.3(TNF):c.-488G>A AND Inherited susceptibility to asthma ClinVar Detail
NM_000594.3(TNF):c.-488G>A AND Malaria, cerebral, susceptibility to ClinVar Detail
NM_000594.3(TNF):c.-488G>A AND Septic shock, susceptibility to ClinVar Detail
NM_000594.3(TNF):c.-488G>A AND Human immunodeficiency virus dementia, susceptibility to ClinVar Detail
NM_000594.3(TNF):c.-488G>A AND Migraine without aura, susceptibility to ClinVar Detail
NM_000594.3(TNF):c.-488G>A AND Psoriatic arthritis, susceptibility to ClinVar Detail
NM_000594.3(TNF):c.-488G>A AND Endometriosis ClinVar Detail
NM_000594.3(TNF):c.-488G>A AND Susceptibility to severe coronavirus disease (COVID-19) due to high p... ClinVar Detail
GSTP1 rs1138272 and TNF rs1800629 SNPs were associated with asthma and wheeze, respectively. DisGeNET Detail
GSTP1 rs1138272 and TNF rs1800629 SNPs were associated with asthma and wheeze, respectively. DisGeNET Detail
GSTP1 rs1138272 and TNF rs1800629 SNPs were associated with asthma and wheeze, respectively. DisGeNET Detail
In this study, the association of the occurrence and clinical characteristics of migraine with the p... DisGeNET Detail
In this study, the association of the occurrence and clinical characteristics of migraine with the p... DisGeNET Detail
All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... DisGeNET Detail
All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... DisGeNET Detail
Genotype AG of rs1800629 (the LTA gene) and genotypes CC and CT of rs1341023 (the BPI gene) were ass... DisGeNET Detail
All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... DisGeNET Detail
To investigate associations between total serum immunoglobulin E (IgE) levels and single nucleotide ... DisGeNET Detail
To investigate associations between total serum immunoglobulin E (IgE) levels and single nucleotide ... DisGeNET Detail
To investigate associations between total serum immunoglobulin E (IgE) levels and single nucleotide ... DisGeNET Detail
All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... DisGeNET Detail
All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... DisGeNET Detail
When compared to controls, the CIN patients showed increased frequencies of CC (rs1554286) and AG+GG... DisGeNET Detail
To investigate the potential association between five cytokine promoter polymorphisms (interleukin [... DisGeNET Detail
To understand the role of genes encoding pro-inflammatory cytokines in epilepsy, this study aimed to... DisGeNET Detail
To replicate and extend recent findings in a Turkish population of associations between chronic rhin... DisGeNET Detail
Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, including IL1RN VNTR (rs3... DisGeNET Detail
To investigate the potential association between five cytokine promoter polymorphisms (interleukin [... DisGeNET Detail
To replicate and extend recent findings in a Turkish population of associations between chronic rhin... DisGeNET Detail
To investigate the potential association between five cytokine promoter polymorphisms (interleukin [... DisGeNET Detail
To replicate and extend recent findings in a Turkish population of associations between chronic rhin... DisGeNET Detail
To understand the role of genes encoding pro-inflammatory cytokines in epilepsy, this study aimed to... DisGeNET Detail
To understand the role of genes encoding pro-inflammatory cytokines in epilepsy, this study aimed to... DisGeNET Detail
To replicate and extend recent findings in a Turkish population of associations between chronic rhin... DisGeNET Detail
To replicate and extend recent findings in a Turkish population of associations between chronic rhin... DisGeNET Detail
To understand the role of genes encoding pro-inflammatory cytokines in epilepsy, this study aimed to... DisGeNET Detail
To investigate the potential association between five cytokine promoter polymorphisms (interleukin [... DisGeNET Detail
The aim of the present study was to investigate a trio of functional SNPs in the promoter regions of... DisGeNET Detail
To understand the role of genes encoding pro-inflammatory cytokines in epilepsy, this study aimed to... DisGeNET Detail
Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, including IL1RN VNTR (rs3... DisGeNET Detail
To replicate and extend recent findings in a Turkish population of associations between chronic rhin... DisGeNET Detail
The following study populations were genotyped for 4 polymorphisms within TNF-beta (rs909253) and TN... DisGeNET Detail
We examined associations between six TNF single nucleotide polymorphisms (SNPs) (rs1799964, rs180063... DisGeNET Detail
The following study populations were genotyped for 4 polymorphisms within TNF-beta (rs909253) and TN... DisGeNET Detail
A haplotype comprising SNPs in two proinflammatory cytokines, tumor necrosis factor-alpha and lympho... DisGeNET Detail
A haplotype comprising SNPs in two proinflammatory cytokines, tumor necrosis factor-alpha and lympho... DisGeNET Detail
Two SNPs, rs1799724 (-850C&gt;T; NT_007592.14:g.22400733C&gt;T) and rs1800629 (-308G&gt;A; [NT_00759... DisGeNET Detail
The following study populations were genotyped for 4 polymorphisms within TNF-beta (rs909253) and TN... DisGeNET Detail
We examined associations between six TNF single nucleotide polymorphisms (SNPs) (rs1799964, rs180063... DisGeNET Detail
In a case-control study, the -238G&gt;A (rs361525), -308G&gt;A (rs1800629), and -857C&gt;T (rs179972... DisGeNET Detail
Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) ... DisGeNET Detail
Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) ... DisGeNET Detail
Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) ... DisGeNET Detail
Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) ... DisGeNET Detail
Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) ... DisGeNET Detail
Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) ... DisGeNET Detail
Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) ... DisGeNET Detail
Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) ... DisGeNET Detail
Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) ... DisGeNET Detail
Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) ... DisGeNET Detail
TNFA-308G&gt;A (rs1800629) and TNFA-1031T&gt;C (rs1799964), which are responsible for increased TNFA... DisGeNET Detail
Presence of combination of HLA-DRB1*07/*15 with either rs1799964 'C/C' genotype or rs1800629 'G/A' g... DisGeNET Detail
[The rs1800629 SNP in TNF interacted with the 1-year change in moderate-to-vigorous physical activit... DisGeNET Detail
We evaluated the association between a G-308A polymorphism (rs1800629) at the TNFA locus and osteopo... DisGeNET Detail
In this regard, besides a strong association between the HLA-DRB1∗04 shared epitope alleles and both... DisGeNET Detail
In this regard, besides a strong association between the HLA-DRB1∗04 shared epitope alleles and both... DisGeNET Detail
Lack of association between TNFα rs1800629 polymorphism and schizophrenia risk: a meta-analysis. DisGeNET Detail
We assessed whether rs1800629 and rs1800795 modified the effect of moderate-to-vigorous physical act... DisGeNET Detail
To explore the association of NFKB1 c.-798_-795delATTG (rs28362491), NFKBIA c.-949C&gt;T (rs2233406)... DisGeNET Detail
Two single nucleotide polymorphisms (SNPs) in adjacent genes, lymphotoxin alpha (LTA +252G, rs909253... DisGeNET Detail
TNF rs1800629 was associated with risk of NHL (OR 1.53, 95% confidence interval, CI, 1.06-2.19 for m... DisGeNET Detail
Subgroup analysis by the types of cervical lesions showed that there was a significant association b... DisGeNET Detail
TNF rs1800629 was associated with risk of NHL (OR 1.53, 95% confidence interval, CI, 1.06-2.19 for m... DisGeNET Detail
Only TNFA rs1800629 was significantly associated with OSA under an allele frequency model (3 studies... DisGeNET Detail
Our study aimed to assess in vitro production of IL-10, IL-6, TNF-A, and adiponectin serum levels in... DisGeNET Detail
TNF rs1800629, which was genotyped in only two of our studies, was also associated with B cell lymph... DisGeNET Detail
The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reac... DisGeNET Detail
The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reac... DisGeNET Detail
Two single nucleotide polymorphisms (SNPs) in adjacent genes, lymphotoxin alpha (LTA +252G, rs909253... DisGeNET Detail
TNF-α SNP rs1800629 and risk of relapse in childhood acute lymphoblastic leukemia: relation to immun... DisGeNET Detail
TNF rs1800629 was associated with risk of NHL (OR 1.53, 95% confidence interval, CI, 1.06-2.19 for m... DisGeNET Detail
TNFA -308 (rs1800629) polymorphism is associated with a higher risk of cardiovascular disease in pat... DisGeNET Detail
The frequency of the A allele in a SNP located in tumor necrosis factor (TNF)-alpha (rs1800629) is s... DisGeNET Detail
The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reac... DisGeNET Detail
Statistically significant interactions with blood transfusion were observed for IL10RA (rs9610) (P(f... DisGeNET Detail
We assessed whether rs1800629 and rs1800795 modified the effect of moderate-to-vigorous physical act... DisGeNET Detail
Statistically significant interactions with blood transfusion were observed for IL10RA (rs9610) (P(f... DisGeNET Detail
To explore the association of NFKB1 c.-798_-795delATTG (rs28362491), NFKBIA c.-949C&gt;T (rs2233406)... DisGeNET Detail
Two single nucleotide polymorphisms (SNPs) in adjacent genes, lymphotoxin alpha (LTA +252G, rs909253... DisGeNET Detail
The aim of this study was to investigate the relationship between the TNF-alpha rs1800629 polymorphi... DisGeNET Detail
In this regard, besides a strong association between the HLA-DRB1∗04 shared epitope alleles and both... DisGeNET Detail
Association of the tumour necrosis factor-α polymorphisms rs361525 and rs1800629 with susceptibility... DisGeNET Detail
In this regard, besides a strong association between the HLA-DRB1∗04 shared epitope alleles and both... DisGeNET Detail
Single-nucleotide polymorphisms in three innate immune genes were associated with development of a C... DisGeNET Detail
Our study aimed to assess in vitro production of IL-10, IL-6, TNF-A, and adiponectin serum levels in... DisGeNET Detail
Variants in TNFα (rs1800629) (GG vs. AG/AA, p &lt; 0.001) and LTA (rs909253) (AA vs. AG/GG, p = 0.02... DisGeNET Detail
Our study aimed to assess in vitro production of IL-10, IL-6, TNF-A, and adiponectin serum levels in... DisGeNET Detail
The presence of at least one A allele in TNF-α SNP rs1800629 should suggest a closer monitoring in B... DisGeNET Detail
TNFA -308 (rs1800629) polymorphism is associated with a higher risk of cardiovascular disease in pat... DisGeNET Detail
Variants in TNFα (rs1800629) (GG vs. AG/AA, p &lt; 0.001) and LTA (rs909253) (AA vs. AG/GG, p = 0.02... DisGeNET Detail
TNF rs1800629, which was genotyped in only two of our studies, was also associated with B cell lymph... DisGeNET Detail
Variants in TNFα (rs1800629) (GG vs. AG/AA, p &lt; 0.001) and LTA (rs909253) (AA vs. AG/GG, p = 0.02... DisGeNET Detail
We found a strong association only between TNF rs1800629 and diffused forms of periodontitis. DisGeNET Detail
TNF rs1800629 was associated with risk of NHL (OR 1.53, 95% confidence interval, CI, 1.06-2.19 for m... DisGeNET Detail
The TNFA rs1800629 gene polymorphism is associated with markers of kidney disease severity and dista... DisGeNET Detail
Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analys... DisGeNET Detail
We investigated whether selected germline SNPs in IL10 (rs1800890, rs1800896, rs1800871, rs1800872),... DisGeNET Detail
Children carrying a minor rs1800629 (TNF) or rs1927911 (TLR4) allele may be at a higher risk of alle... DisGeNET Detail
In this regard, besides a strong association between the HLA-DRB1∗04 shared epitope alleles and both... DisGeNET Detail
The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reac... DisGeNET Detail
Subgroup analysis by the types of cervical lesions showed that there was a significant association b... DisGeNET Detail
The aim of this study was to investigate the relationship between the TNF-alpha rs1800629 polymorphi... DisGeNET Detail
Association between tumor necrosis factor-α rs1800629 polymorphism and risk of gastric cancer: a met... DisGeNET Detail
There are inconclusive data on the tumor necrosis factor-α (TNF-α) -308 G/A (rs1800629) polymorphism... DisGeNET Detail
[The rs1800629 SNP in TNF interacted with the 1-year change in moderate-to-vigorous physical activit... DisGeNET Detail
The purpose of the present study was to investigate a hypothesized association between two common fu... DisGeNET Detail
Association between tumor necrosis factor-α rs1800629 polymorphism and risk of gastric cancer: a met... DisGeNET Detail
We investigated whether selected germline SNPs in IL10 (rs1800890, rs1800896, rs1800871, rs1800872),... DisGeNET Detail
We investigated whether selected germline SNPs in IL10 (rs1800890, rs1800896, rs1800871, rs1800872),... DisGeNET Detail
[The rs1800629 SNP in TNF interacted with the 1-year change in moderate-to-vigorous physical activit... DisGeNET Detail
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23... DisGeNET Detail
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23... DisGeNET Detail
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23... DisGeNET Detail
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23... DisGeNET Detail
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23... DisGeNET Detail
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23... DisGeNET Detail
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23... DisGeNET Detail
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23... DisGeNET Detail
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23... DisGeNET Detail
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23... DisGeNET Detail
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23... DisGeNET Detail
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23... DisGeNET Detail
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23... DisGeNET Detail
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23... DisGeNET Detail
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23... DisGeNET Detail
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23... DisGeNET Detail
Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in... DisGeNET Detail
Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in... DisGeNET Detail
Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in... DisGeNET Detail
With the aim to conclusively validate the strongest associations so far reported, we selected the po... DisGeNET Detail
With the aim to conclusively validate the strongest associations so far reported, we selected the po... DisGeNET Detail
With the aim to conclusively validate the strongest associations so far reported, we selected the po... DisGeNET Detail
Gene
-
dbSNP
rs1800629 dbSNP
Genome
hg38
Position
chr6:31,575,254-31,575,254
Variant Type
snv
Reference Allele
G
Alternative Allele
A
ToMMo VCF FILTER column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
PASS
Total VCF ID column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
rs1800629
Allele frequency, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
0.0105
Allele count in genotypes, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
176
Total number of alleles in called genotypes (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
16760
East Asian Chromosome Counts (ExAC)
784
East Asian Allele Counts (ExAC)
130
East Asian Heterozygous Counts (ExAC)
120
East Asian Homozygous Counts (ExAC)
5
East Asian Allele Frequency (ExAC)
0.16581632653061223
Chromosome Counts in All Race (ExAC)
20094
Allele Counts in All Race (ExAC)
3247
Heterozygous Counts in All Race (ExAC)
2865
Homozygous Counts in All Race (ExAC)
191
Allele Frequency in All Race (ExAC)
0.16159052453468697
Genome browser