Annotation Detail
Information
- Associated Genes
- LTA
- Associated Variants
-
LTA p.Cys13Arg (p.C13R)
(
ENST00000454783.5,
ENST00000418386.3 )
LTA p.Thr60Asn (p.T60N) ( ENST00000454783.5, ENST00000418386.3 )
NC_000006.12:g.31574699C>A
TNF c.-488G>A
NC_000006.12:g.31575324G>A
TNF c.186+123G>A ( ENST00000449264.3, ENST00000699334.1 )
LTA p.Cys13Arg (p.C13R) ( ENST00000418386.3, ENST00000454783.5 )
LTA p.Thr60Asn (p.T60N) ( ENST00000418386.3, ENST00000454783.5 )
NC_000006.12:g.31574699C>A
TNF c.-488G>A
NC_000006.12:g.31575324G>A
TNF c.186+123G>A ( ENST00000449264.3, ENST00000699334.1 ) - Associated Disease
- Metabolic syndrome X
- Source Database
- DisGeNET
- Description
- Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in the TNF-LTA locus encoding the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha have been shown to be associated with various metabolic traits including susceptibility to type 2 diabetes, metabolic syndrome, insulin resistance, and increased body mass index (BMI) in Caucasians from different geographic locations and have yielded mixed results.
- Pubmed
- 20177654
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00872974716828791
- Year of publication
- 2010
Drugs