chr6:31543101:G>A Detail (hg19) (TNF)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr6:31,543,101-31,543,101 |
| hg38 | chr6:31,575,324-31,575,324 View the variant detail on this assembly version. |
HGVS
[No Data.]
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
| JP | HGVD:[No Data.] |
| ToMMo:0.018 | |
| NCBN:[No Data.] | |
| NCBN(Hondo):[No Data.] | |
| NCBN(Ryukyu):[No Data.] | |
| East asia | ExAC:[No Data.] |
Prediction
ClinVar
| Clinical Significance |
Uncertain significance
|
| Review star |  |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
| Clinical significance | Last evaluated | Review status | Condition | Origin | Links |
|---|---|---|---|---|---|
|
Uncertain significance
|
2021-02-09 | no assertion criteria provided | Susceptibility to severe coronavirus disease (COVID-19) |
germline
|
Detail |
|
Uncertain significance
|
2021-08-07 | no assertion criteria provided | Susceptibility to severe coronavirus disease (COVID-19) due to high plasma levels of TNF, TNFR, and/or TNFR5 |
germline
|
Detail |
CIViC
[No Data.]
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| <0.001 | Invasive breast carcinoma | In conclusion, our data provide persuasive evidence against an overall associati... | BeFree | 19423537 | Detail |
| 0.001 | breast carcinoma | Previous studies have suggested that minor alleles for ERCC4 rs744154, TNF rs361... | BeFree | 19423537 | Detail |
| 0.006 | Malignant neoplasm of breast | Previous studies have suggested that minor alleles for ERCC4 rs744154, TNF rs361... | BeFree | 19423537 | Detail |
| <0.001 | craniosynostosis | To replicate and extend recent findings in a Turkish population of associations ... | BeFree | 20157068 | Detail |
| <0.001 | Chronic sinusitis | To replicate and extend recent findings in a Turkish population of associations ... | BeFree | 20157068 | Detail |
| 0.008 | Nasal Polyps | To replicate and extend recent findings in a Turkish population of associations ... | BeFree | 20157068 | Detail |
| <0.001 | craniosynostosis | To replicate and extend recent findings in a Turkish population of associations ... | BeFree | 20157068 | Detail |
| 0.010 | Nasal Polyps | To replicate and extend recent findings in a Turkish population of associations ... | BeFree | 20157068 | Detail |
| <0.001 | Chronic sinusitis | To replicate and extend recent findings in a Turkish population of associations ... | BeFree | 20157068 | Detail |
| 0.012 | Malignant neoplasm of ovary | We examined associations between six TNF single nucleotide polymorphisms (SNPs) ... | BeFree | 18196539 | Detail |
| 0.050 | Lymphoma, Non-Hodgkin | A haplotype comprising SNPs in two proinflammatory cytokines, tumor necrosis fac... | BeFree | 17018637 | Detail |
| 0.026 | Lymphoma, Non-Hodgkin | A haplotype comprising SNPs in two proinflammatory cytokines, tumor necrosis fac... | BeFree | 17018637 | Detail |
| 0.012 | ovarian carcinoma | We examined associations between six TNF single nucleotide polymorphisms (SNPs) ... | BeFree | 18196539 | Detail |
| 0.024 | diabetic retinopathy | In a case-control study, the -238G>A (rs361525), -308G>A (rs1800629), and ... | BeFree | 25634985 | Detail |
| <0.001 | breast carcinoma | To explore the association of NFKB1 c.-798_-795delATTG (rs28362491), NFKBIA c.-9... | BeFree | 25559835 | Detail |
| 0.003 | Malignant neoplasm of breast | To explore the association of NFKB1 c.-798_-795delATTG (rs28362491), NFKBIA c.-9... | BeFree | 25559835 | Detail |
| 0.187 | psoriasis | Association of the tumour necrosis factor-α polymorphisms rs361525 and rs1800629... | BeFree | 24252077 | Detail |
| 0.003 | exfoliation syndrome | The purpose of the present study was to investigate a hypothesized association b... | BeFree | 19279689 | Detail |
| 0.008 | Chronic Obstructive Airway Disease | Patients with polymorphism had more chronic bronchitis, a lower body mass index,... | BeFree | 20299531 | Detail |
| 0.185 | Chronic Obstructive Airway Disease | [Tumor necrosis factor-{alpha} rs361525 polymorphism is associated with increase... | GAD | 20299531 | Detail |
| 0.005 | juvenile rheumatoid arthritis | Several meta-analyses and replicated association studies have implicated the min... | BeFree | 24069456 | Detail |
| 0.185 | Chronic Obstructive Airway Disease | The rs361525 polymorphism does not increase production of tumor necrosis factor ... | BeFree | 26620975 | Detail |
| 0.158 | Liver neoplasms | [This meta-analysis supports TNF rs361525 (-238G>A) polymorphism being associate... | GAD | 20953524 | Detail |
| <0.001 | osteochondritis dissecans | We found that the A allele of the TNFA rs361525 polymorphism was significantly a... | BeFree | 22311210 | Detail |
| 0.058 | liver carcinoma | [Tumor necrosis factor rs361525 (-238G>A) polymorphism contributes to hepatocell... | GAD | 20953524 | Detail |
| <0.001 | alpha-1-Antitrypsin Deficiency, Autosomal Recessive | Previous work has shown that COPD/chronic bronchitis subjects with alpha-1 antit... | BeFree | 26620975 | Detail |
| 0.045 | Juvenile arthritis | Several meta-analyses and replicated association studies have implicated the min... | BeFree | 24069456 | Detail |
| 0.008 | alpha 1-antitrypsin deficiency | Previous work has shown that COPD/chronic bronchitis subjects with alpha-1 antit... | BeFree | 26620975 | Detail |
| 0.092 | uveitis | [The role of 12 polymorphisms spanning the TNFA and IL10 genomic regions was inv... | GAD | 20335604 | Detail |
| 0.058 | liver carcinoma | Tumor necrosis factor rs361525 (-238G>A) polymorphism contributes to hepatoce... | BeFree | 20953524 | Detail |
| 0.011 | Bronchitis, Chronic | Previous work has shown that COPD/chronic bronchitis subjects with alpha-1 antit... | BeFree | 26620975 | Detail |
| 0.185 | Chronic Obstructive Airway Disease | Tumor necrosis factor-{alpha} rs361525 polymorphism is associated with increased... | BeFree | 20299531 | Detail |
| 0.179 | Chronic Obstructive Airway Disease | The rs361525 polymorphism does not increase production of tumor necrosis factor ... | BeFree | 26620975 | Detail |
| 0.009 | ulcerative colitis | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.033 | ulcerative colitis | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.008 | Crohn Disease | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.005 | Crohn Disease | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.010 | ulcerative colitis | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.003 | Crohn Disease | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.098 | Crohn Disease | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.012 | ulcerative colitis | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.183 | Crohn Disease | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.422 | Crohn Disease | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.003 | ulcerative colitis | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.131 | Crohn Disease | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| <0.001 | ulcerative colitis | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.008 | ulcerative colitis | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.004 | ulcerative colitis | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| <0.001 | ulcerative colitis | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.034 | ulcerative colitis | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.144 | ulcerative colitis | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| <0.001 | Crohn Disease | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.008 | ulcerative colitis | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.130 | Crohn Disease | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.187 | ulcerative colitis | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.012 | ulcerative colitis | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.004 | Crohn Disease | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.131 | ulcerative colitis | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| <0.001 | Crohn Disease | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.009 | Crohn Disease | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory resp... | BeFree | 24776844 | Detail |
| 0.031 | Diabetes Mellitus, Non-Insulin-Dependent | Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs36152... | BeFree | 20177654 | Detail |
| 0.022 | Metabolic syndrome X | Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs36152... | BeFree | 20177654 | Detail |
| 0.009 | Metabolic syndrome X | Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs36152... | BeFree | 20177654 | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| NC_000006.12:g.31575324G>A AND Susceptibility to severe coronavirus disease (COVID-19) | ClinVar | Detail |
| NC_000006.12:g.31575324G>A AND Susceptibility to severe coronavirus disease (COVID-19) due to high p... | ClinVar | Detail |
| In conclusion, our data provide persuasive evidence against an overall association between invasive ... | DisGeNET | Detail |
| Previous studies have suggested that minor alleles for ERCC4 rs744154, TNF rs361525, CASP10 rs130106... | DisGeNET | Detail |
| Previous studies have suggested that minor alleles for ERCC4 rs744154, TNF rs361525, CASP10 rs130106... | DisGeNET | Detail |
| To replicate and extend recent findings in a Turkish population of associations between chronic rhin... | DisGeNET | Detail |
| To replicate and extend recent findings in a Turkish population of associations between chronic rhin... | DisGeNET | Detail |
| To replicate and extend recent findings in a Turkish population of associations between chronic rhin... | DisGeNET | Detail |
| To replicate and extend recent findings in a Turkish population of associations between chronic rhin... | DisGeNET | Detail |
| To replicate and extend recent findings in a Turkish population of associations between chronic rhin... | DisGeNET | Detail |
| To replicate and extend recent findings in a Turkish population of associations between chronic rhin... | DisGeNET | Detail |
| We examined associations between six TNF single nucleotide polymorphisms (SNPs) (rs1799964, rs180063... | DisGeNET | Detail |
| A haplotype comprising SNPs in two proinflammatory cytokines, tumor necrosis factor-alpha and lympho... | DisGeNET | Detail |
| A haplotype comprising SNPs in two proinflammatory cytokines, tumor necrosis factor-alpha and lympho... | DisGeNET | Detail |
| We examined associations between six TNF single nucleotide polymorphisms (SNPs) (rs1799964, rs180063... | DisGeNET | Detail |
| In a case-control study, the -238G>A (rs361525), -308G>A (rs1800629), and -857C>T (rs179972... | DisGeNET | Detail |
| To explore the association of NFKB1 c.-798_-795delATTG (rs28362491), NFKBIA c.-949C>T (rs2233406)... | DisGeNET | Detail |
| To explore the association of NFKB1 c.-798_-795delATTG (rs28362491), NFKBIA c.-949C>T (rs2233406)... | DisGeNET | Detail |
| Association of the tumour necrosis factor-α polymorphisms rs361525 and rs1800629 with susceptibility... | DisGeNET | Detail |
| The purpose of the present study was to investigate a hypothesized association between two common fu... | DisGeNET | Detail |
| Patients with polymorphism had more chronic bronchitis, a lower body mass index, and a greater annua... | DisGeNET | Detail |
| [Tumor necrosis factor-{alpha} rs361525 polymorphism is associated with increased local production a... | DisGeNET | Detail |
| Several meta-analyses and replicated association studies have implicated the minor 'A' variant withi... | DisGeNET | Detail |
| The rs361525 polymorphism does not increase production of tumor necrosis factor alpha by monocytes f... | DisGeNET | Detail |
| [This meta-analysis supports TNF rs361525 (-238G>A) polymorphism being associated with HCC in an Asi... | DisGeNET | Detail |
| We found that the A allele of the TNFA rs361525 polymorphism was significantly associated with OCD s... | DisGeNET | Detail |
| [Tumor necrosis factor rs361525 (-238G>A) polymorphism contributes to hepatocellular carcinoma susce... | DisGeNET | Detail |
| Previous work has shown that COPD/chronic bronchitis subjects with alpha-1 antitrypsin deficiency wi... | DisGeNET | Detail |
| Several meta-analyses and replicated association studies have implicated the minor 'A' variant withi... | DisGeNET | Detail |
| Previous work has shown that COPD/chronic bronchitis subjects with alpha-1 antitrypsin deficiency wi... | DisGeNET | Detail |
| [The role of 12 polymorphisms spanning the TNFA and IL10 genomic regions was investigated in 192 uve... | DisGeNET | Detail |
| Tumor necrosis factor rs361525 (-238G>A) polymorphism contributes to hepatocellular carcinoma sus... | DisGeNET | Detail |
| Previous work has shown that COPD/chronic bronchitis subjects with alpha-1 antitrypsin deficiency wi... | DisGeNET | Detail |
| Tumor necrosis factor-{alpha} rs361525 polymorphism is associated with increased local production an... | DisGeNET | Detail |
| The rs361525 polymorphism does not increase production of tumor necrosis factor alpha by monocytes f... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs380409... | DisGeNET | Detail |
| Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in... | DisGeNET | Detail |
| Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in... | DisGeNET | Detail |
| Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in... | DisGeNET | Detail |
- Gene
- -
- dbSNP
- rs361525 dbSNP
- Genome
- hg19
- Position
- chr6:31,543,101-31,543,101
- Variant Type
- snv
- Reference Allele
- G
- Alternative Allele
- A
- ToMMo VCF FILTER column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- PASS
- Total VCF ID column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- rs361525
- Allele frequency, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- 0.0175
- Allele count in genotypes, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- 293
- Total number of alleles in called genotypes (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- 16760
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