Annotation Detail
Information
- Associated Genes
- TNF
- Associated Variants
-
LTA c.-10+62A>C
(
ENST00000418386.3,
ENST00000454783.5 )
LTA c.-9-198A>G ( ENST00000454783.5, ENST00000418386.3 )
TNF c.-1037C>T
TNF c.-488G>A
NC_000006.12:g.31575324G>A
LTA c.-10+62A>C ( ENST00000418386.3, ENST00000454783.5 )
LTA c.-9-198A>G ( ENST00000418386.3, ENST00000454783.5 )
TNF c.-1037C>T
TNF c.-488G>A
NC_000006.12:g.31575324G>A - Associated Disease
- Lymphoma, Non-Hodgkin
- Source Database
- DisGeNET
- Description
- A haplotype comprising SNPs in two proinflammatory cytokines, tumor necrosis factor-alpha and lymphotoxin-alpha (rs1800629, rs361525, rs1799724, rs909253, and rs2239704), increased non-Hodgkin lymphoma risk overall (OR, 1.31; 95% CI, 1.06-1.63; P = 0.01) and notably for diffuse large B cell (OR, 1.64; 95% CI, 1.23-2.19; P = 0.0007).
- Pubmed
- 17018637
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0497499406807093
- Year of publication
- 2006
Drugs