chr6:31542482:C>T Detail (hg19) (TNF)

Information

Genome

Assembly Position
hg19 chr6:31,542,482-31,542,482
hg38 chr6:31,574,705-31,574,705 View the variant detail on this assembly version.

HGVS

[No Data.]
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

JP HGVD:[No Data.]
ToMMo:0.171
NCBN:[No Data.]
NCBN(Hondo):[No Data.]
NCBN(Ryukyu):[No Data.]
East asia ExAC:[No Data.]

Prediction

ClinVar

Clinical Significance risk factor
Review star
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
Clinical significance Last evaluated Review status Condition Origin Links
risk factor 2005-07-01 no assertion criteria provided Vascular dementia, susceptibility to germline Detail
risk factor 2005-07-01 no assertion criteria provided Alzheimer disease, susceptibility to germline Detail
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.070 Malignant neoplasm of breast Among premenopausal AA women, comparing variant allele carriers to non-carriers,... BeFree 23991131 Detail
<0.001 Malignant neoplasm of breast Among premenopausal AA women, comparing variant allele carriers to non-carriers,... BeFree 23991131 Detail
0.028 breast carcinoma Among premenopausal AA women, comparing variant allele carriers to non-carriers,... BeFree 23991131 Detail
0.001 breast carcinoma Among premenopausal AA women, comparing variant allele carriers to non-carriers,... BeFree 23991131 Detail
<0.001 breast carcinoma Among premenopausal AA women, comparing variant allele carriers to non-carriers,... BeFree 23991131 Detail
<0.001 Malignant neoplasm of breast Among premenopausal AA women, comparing variant allele carriers to non-carriers,... BeFree 23991131 Detail
0.009 Carcinoma of lung We evaluated the role of tumor necrosis factor α (TNFA) rs1799724, interleukin 1... BeFree 24139238 Detail
0.078 Malignant neoplasm of lung We evaluated the role of tumor necrosis factor α (TNFA) rs1799724, interleukin 1... BeFree 24139238 Detail
0.042 Malignant neoplasm of lung As TNFA triggers a cytokine cascade, the modifying effect of the TNFA rs1799724 ... BeFree 24139238 Detail
<0.001 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site The following study populations were genotyped for 4 polymorphisms within TNF-be... BeFree 18811622 Detail
0.009 Febrile Convulsions The promoter SNPs of four inflammatory cytokine genes (IL6 -572C/G, IL8 -251A/T,... BeFree 19055487 Detail
0.012 Malignant neoplasm of ovary We examined associations between six TNF single nucleotide polymorphisms (SNPs) ... BeFree 18196539 Detail
0.011 Carcinoma of lung As TNFA triggers a cytokine cascade, the modifying effect of the TNFA rs1799724 ... BeFree 24139238 Detail
<0.001 bronchiolitis The following study populations were genotyped for 4 polymorphisms within TNF-be... BeFree 18811622 Detail
0.050 Lymphoma, Non-Hodgkin A haplotype comprising SNPs in two proinflammatory cytokines, tumor necrosis fac... BeFree 17018637 Detail
0.006 Febrile Convulsions The promoter SNPs of four inflammatory cytokine genes (IL6 -572C/G, IL8 -251A/T,... BeFree 19055487 Detail
0.026 Lymphoma, Non-Hodgkin A haplotype comprising SNPs in two proinflammatory cytokines, tumor necrosis fac... BeFree 17018637 Detail
0.237 obesity Our aim was to study the role of TNF-α in the pathogenesis of IR and Ob in PCOS,... BeFree 25083576 Detail
0.027 Malaria, Falciparum We examined a possible association of three single nucleotide polymorphisms (SNP... BeFree 17493155 Detail
0.440 Alzheimer's disease Two SNPs, rs1799724 (-850C&gt;T; NT_007592.14:g.22400733C&gt;T) and rs1800629 (-... BeFree 15895461 Detail
0.049 asthma The following study populations were genotyped for 4 polymorphisms within TNF-be... BeFree 18811622 Detail
<0.001 hyperandrogenism In conclusion, our present results suggest that the TNF-α system might contribut... BeFree 25083576 Detail
0.012 ovarian carcinoma We examined associations between six TNF single nucleotide polymorphisms (SNPs) ... BeFree 18196539 Detail
0.024 diabetic retinopathy In a case-control study, the -238G&gt;A (rs361525), -308G&gt;A (rs1800629), and ... BeFree 25634985 Detail
0.002 Chronic Kidney Diseases Subsequent multivariable logistic regression analysis with adjustment for covari... BeFree 19282863 Detail
<0.001 Chronic Kidney Diseases Subsequent multivariable logistic regression analysis with adjustment for covari... BeFree 19282863 Detail
<0.001 Chronic Kidney Diseases Subsequent multivariable logistic regression analysis with adjustment for covari... BeFree 19282863 Detail
<0.001 Chronic Kidney Diseases Subsequent multivariable logistic regression analysis with adjustment for covari... BeFree 19282863 Detail
Annotation

Annotations

DescrptionSourceLinks
NM_000594.3(TNF):c.-1037C>T AND Vascular dementia, susceptibility to ClinVar Detail
NM_000594.3(TNF):c.-1037C>T AND Alzheimer disease, susceptibility to ClinVar Detail
Among premenopausal AA women, comparing variant allele carriers to non-carriers, reduced breast canc... DisGeNET Detail
Among premenopausal AA women, comparing variant allele carriers to non-carriers, reduced breast canc... DisGeNET Detail
Among premenopausal AA women, comparing variant allele carriers to non-carriers, reduced breast canc... DisGeNET Detail
Among premenopausal AA women, comparing variant allele carriers to non-carriers, reduced breast canc... DisGeNET Detail
Among premenopausal AA women, comparing variant allele carriers to non-carriers, reduced breast canc... DisGeNET Detail
Among premenopausal AA women, comparing variant allele carriers to non-carriers, reduced breast canc... DisGeNET Detail
We evaluated the role of tumor necrosis factor α (TNFA) rs1799724, interleukin 1β (IL1B) rs16944, IL... DisGeNET Detail
We evaluated the role of tumor necrosis factor α (TNFA) rs1799724, interleukin 1β (IL1B) rs16944, IL... DisGeNET Detail
As TNFA triggers a cytokine cascade, the modifying effect of the TNFA rs1799724 genotypes on the ass... DisGeNET Detail
The following study populations were genotyped for 4 polymorphisms within TNF-beta (rs909253) and TN... DisGeNET Detail
The promoter SNPs of four inflammatory cytokine genes (IL6 -572C/G, IL8 -251A/T, IL10 -592A/C and TN... DisGeNET Detail
We examined associations between six TNF single nucleotide polymorphisms (SNPs) (rs1799964, rs180063... DisGeNET Detail
As TNFA triggers a cytokine cascade, the modifying effect of the TNFA rs1799724 genotypes on the ass... DisGeNET Detail
The following study populations were genotyped for 4 polymorphisms within TNF-beta (rs909253) and TN... DisGeNET Detail
A haplotype comprising SNPs in two proinflammatory cytokines, tumor necrosis factor-alpha and lympho... DisGeNET Detail
The promoter SNPs of four inflammatory cytokine genes (IL6 -572C/G, IL8 -251A/T, IL10 -592A/C and TN... DisGeNET Detail
A haplotype comprising SNPs in two proinflammatory cytokines, tumor necrosis factor-alpha and lympho... DisGeNET Detail
Our aim was to study the role of TNF-α in the pathogenesis of IR and Ob in PCOS, as well as a C850T ... DisGeNET Detail
We examined a possible association of three single nucleotide polymorphisms (SNPs) of the tumor necr... DisGeNET Detail
Two SNPs, rs1799724 (-850C&gt;T; NT_007592.14:g.22400733C&gt;T) and rs1800629 (-308G&gt;A; [NT_00759... DisGeNET Detail
The following study populations were genotyped for 4 polymorphisms within TNF-beta (rs909253) and TN... DisGeNET Detail
In conclusion, our present results suggest that the TNF-α system might contribute to the pathogenesi... DisGeNET Detail
We examined associations between six TNF single nucleotide polymorphisms (SNPs) (rs1799964, rs180063... DisGeNET Detail
In a case-control study, the -238G&gt;A (rs361525), -308G&gt;A (rs1800629), and -857C&gt;T (rs179972... DisGeNET Detail
Subsequent multivariable logistic regression analysis with adjustment for covariates as well as a st... DisGeNET Detail
Subsequent multivariable logistic regression analysis with adjustment for covariates as well as a st... DisGeNET Detail
Subsequent multivariable logistic regression analysis with adjustment for covariates as well as a st... DisGeNET Detail
Subsequent multivariable logistic regression analysis with adjustment for covariates as well as a st... DisGeNET Detail
Gene
-
dbSNP
rs1799724 dbSNP
Genome
hg19
Position
chr6:31,542,482-31,542,482
Variant Type
snv
Reference Allele
C
Alternative Allele
T
ToMMo VCF FILTER column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
PASS
Total VCF ID column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
rs1799724
Allele frequency, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
0.1714
Allele count in genotypes, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
2872
Total number of alleles in called genotypes (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
16760
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