Annotation Detail
Information
- Associated Genes
- TNF
- Associated Variants
-
NC_000006.12:g.31575324G>A
NC_000006.12:g.31575324G>A - Associated Disease
- juvenile rheumatoid arthritis
- Source Database
- DisGeNET
- Description
- Several meta-analyses and replicated association studies have implicated the minor 'A' variant within the TNF promoter single nucleotide polymorphism (SNP) rs361525 (-238A/G) as a risk allele in joint related disorders, including psoriatic and juvenile idiopathic arthritis, and osteolysis after joint arthroplasty.
- Pubmed
- 24069456
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00542883744160607
- Year of publication
- 2013
Drugs