Annotation Detail
Information
- Associated Genes
- IL1B
- Associated Variants
-
NC_000002.12:g.112837290A>G
TNF c.-488G>A
IL6 c.-84-153C>G ( ENST00000404625.5 )
NC_000002.12:g.112837290A>G
TNF c.-488G>A
IL6 c.-84-153C>G ( ENST00000404625.5 ) - Associated Disease
- Seizures
- Source Database
- DisGeNET
- Description
- To understand the role of genes encoding pro-inflammatory cytokines in epilepsy, this study aimed to evaluate the polymorphisms of the promoter regions of IL-1β-511C>T (rs16944), TNF-α-308G>A (rs1800629) and IL-6-174G>C (rs1800795) genes and to look into the interaction between these genes in influencing seizure susceptibility, seizure frequency and response to therapy.
- Pubmed
- 22578659
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.204353001474949
- Year of publication
- 2012
Drugs