Annotation Detail

Information
Associated Genes
SERPINE1
Associated Variants
rs12147254 ( ENST00000539721.5, ENST00000392745.8, ENST00000351691.10, ENST00000560371.5 )
CCR7 c.10+1853G>A ( ENST00000246657.2 )
GYS1 c.*725C>T ( ENST00000263276.6, ENST00000323798.8 )
MTHFR p.Ala263Val (p.A263V) ( ENST00000376585.6, ENST00000376583.7, ENST00000376590.9, ENST00000376592.6, ENST00000423400.7, ENST00000641407.1, ENST00000641820.1 )
DNAJC16 c.575-2202A>G ( ENST00000375847.8, ENST00000375838.5, ENST00000375849.5, ENST00000616884.4 )
EPHX1 p.His139Arg (p.H139R) ( ENST00000272167.10, ENST00000366837.5, ENST00000614058.4 )
EPHX1 p.His139Leu (p.H139L) ( ENST00000614058.4, ENST00000366837.5, ENST00000272167.10 )
MTR p.Asp919Gly (p.D919G) ( ENST00000366577.10, ENST00000535889.6, ENST00000681177.1, ENST00000681102.1, ENST00000679842.1, ENST00000674797.2 )
NC_000002.12:g.112837290A>G
TNF c.-488G>A
SERPINE1 c.506-407A>G ( ENST00000223095.5 )
rs17501108
rs12147254 ( ENST00000351691.10, ENST00000392745.8, ENST00000539721.5, ENST00000560371.5 )
CCR7 c.10+1853G>A ( ENST00000246657.2 )
GYS1 c.*725C>T ( ENST00000263276.6, ENST00000323798.8 )
MTHFR p.Ala263Val (p.A263V) ( ENST00000376583.7, ENST00000376585.6, ENST00000376590.9, ENST00000376592.6, ENST00000423400.7, ENST00000641407.1, ENST00000641820.1 )
DNAJC16 c.575-2202A>G ( ENST00000375838.5, ENST00000375847.8, ENST00000375849.5, ENST00000616884.4 )
EPHX1 p.His139Arg (p.H139R) ( ENST00000272167.10, ENST00000366837.5, ENST00000614058.4 )
EPHX1 p.His139Leu (p.H139L) ( ENST00000272167.10, ENST00000366837.5, ENST00000614058.4 )
MTR p.Asp919Gly (p.D919G) ( ENST00000366577.10, ENST00000535889.6, ENST00000674797.2, ENST00000679842.1, ENST00000681102.1, ENST00000681177.1 )
NC_000002.12:g.112837290A>G
TNF c.-488G>A
SERPINE1 c.506-407A>G ( ENST00000223095.5 )
rs17501108
Associated Disease
5,10-Methylenetetrahydrofolate reductase deficiency
Source Database
DisGeNET
Description
With the aim to conclusively validate the strongest associations so far reported, we selected the polymorphisms rs2227667 (SERPINE1), rs17501108 (HGF), rs3136685 (CCR7), rs16944 (IL1B), rs12147254 (TRAF3), rs1805087 (MTR), rs1800629 (TNF-α), rs7516435 (CASP9), rs1042265 (BAX), rs2234922 (mEH), and rs1801133 (MTHFR).
Pubmed
24521996
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.00081432561624091
Year of publication
2015
Drugs