chr22:19941371:> Detail (hg38)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr22:19,928,894-19,957,498 |
| hg38 | chr22:19,941,371-19,969,975 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| 0.003 | renal cell carcinoma | NA | BeFree,GAD | Detail | |
| <0.001 | squamous cell carcinoma | NA | BeFree | Detail | |
| 0.003 | Cardiovascular Diseases | NA | BeFree,GAD | Detail | |
| <0.001 | carpal tunnel syndrome | NA | BeFree | Detail | |
| 0.080 | Catalepsy | NA | RGD | Detail | |
| 0.002 | Neoplastic Cell Transformation | NA | GAD | Detail | |
| <0.001 | Neck Pain | NA | BeFree | Detail | |
| 0.005 | Chromosome Aberrations | NA | GAD | Detail | |
| 0.005 | Chromosome Deletion | NA | GAD | Detail | |
| 0.120 | Cognition Disorders | NA | CTD_human | Detail | |
| 0.003 | Colonic Neoplasms | NA | LHGDN | Detail | |
| <0.001 | colorectal carcinoma | Catechol-O-methyltransferase inhibits colorectal cancer cell proliferation and i... | BeFree | 25532943 | Detail |
| 0.003 | Hereditary nonpolyposis colorectal neoplasms | NA | LHGDN | Detail | |
| 0.002 | Constipation | NA | GAD | Detail | |
| <0.001 | Coronary Arteriosclerosis | NA | BeFree | Detail | |
| <0.001 | Coronary heart disease | NA | BeFree | Detail | |
| 0.002 | Crohn Disease | NA | GAD | Detail | |
| <0.001 | Delusions | NA | BeFree | Detail | |
| 0.002 | Presenile dementia | NA | BeFree | Detail | |
| 0.038 | Mental Depression | Brooding rumination and heart rate variability in women at high and low risk for... | BeFree,GAD | 24661160 | Detail |
| 0.038 | Mental Depression | An interaction with catechol-O-methyltransferase (COMT) has also been proved aff... | BeFree,GAD | 26021967 | Detail |
| <0.001 | Endogenous depression | NA | BeFree | Detail | |
| 0.009 | depressive disorder | Brooding rumination and heart rate variability in women at high and low risk for... | BeFree | 24661160 | Detail |
| 0.009 | depressive disorder | An interaction with catechol-O-methyltransferase (COMT) has also been proved aff... | BeFree | 26021967 | Detail |
| 0.003 | diabetes mellitus | NA | BeFree,GAD | Detail | |
| 0.080 | Diabetes Mellitus, Experimental | NA | RGD | Detail | |
| 0.003 | Diabetes Mellitus, Non-Insulin-Dependent | NA | BeFree,GAD | Detail | |
| 0.003 | diarrhea | In contrast, compared with control subjects, COMT 158Met was significantly more ... | BeFree,GAD | 25037115 | Detail |
| 0.280 | DiGeorge syndrome | Nine of ∼30 genes involved in 22qDS have the potential of disrupting mitochondri... | BeFree,CTD_human,GAD,LHGDN,ORPHANET | 26221035 | Detail |
| <0.001 | Disruptive Behavior Disorder | NA | BeFree | Detail | |
| <0.001 | Dizziness | NA | BeFree | Detail | |
| 0.002 | DNA Damage | NA | GAD | Detail | |
| 0.001 | Drug abuse | NA | BeFree | Detail | |
| 0.004 | Dyskinetic syndrome | Our findings suggest that polymorphisms in COMT and MAO-B may increase the risk ... | BeFree,LHGDN | 25034874 | Detail |
| 0.082 | Dyskinesia, Drug-Induced | NA | GAD,RGD | Detail | |
| 0.005 | Dyspepsia | NA | BeFree,GAD,LHGDN | Detail | |
| 0.006 | Eating Disorders | NA | BeFree,GAD | Detail | |
| <0.001 | eclampsia | NA | BeFree | Detail | |
| 0.002 | Endocrine System Diseases | NA | GAD | Detail | |
| 0.015 | Endometrial Neoplasms | NA | GAD,LHGDN | Detail | |
| 0.007 | endometriosis | COMT 158G/A and CYP1B1 432C/G polymorphisms increase the risk of endometriosis a... | BeFree,GAD | 24965973 | Detail |
| <0.001 | epilepsy | NA | BeFree | Detail | |
| 0.005 | Esophageal Neoplasms | NA | GAD | Detail | |
| <0.001 | Fatigue | NA | BeFree | Detail | |
| 0.005 | chronic fatigue syndrome | NA | GAD | Detail | |
| 0.122 | Fetal Growth Retardation | NA | CTD_human,GAD | Detail | |
| <0.001 | breast fibrocystic disease | NA | BeFree | Detail | |
| <0.001 | Flushing | NA | BeFree | Detail | |
| 0.003 | gastritis | NA | BeFree,GAD | Detail | |
| 0.002 | Gastrointestinal Diseases | NA | GAD | Detail | |
| 0.002 | Female Genital Diseases | NA | GAD | Detail | |
| 0.002 | gout | NA | GAD | Detail | |
| 0.006 | Hallucinations | NA | BeFree,GAD | Detail | |
| 0.005 | Head and Neck Neoplasms | NA | GAD | Detail | |
| 0.006 | Headache | NA | BeFree,GAD | Detail | |
| 0.001 | Atrial Septal Defects | Our results suggest that PRODH and COMT may interact to contribute to the ASD ph... | BeFree | 25325218 | Detail |
| <0.001 | hepatitis C | NA | BeFree | Detail | |
| 0.003 | Herpes Simplex Infections | NA | BeFree,GAD | Detail | |
| 0.002 | Hyperalgesia | NA | GAD | Detail | |
| 0.093 | Hypertensive disease | NA | BeFree,GAD,LHGDN,RGD | Detail | |
| <0.001 | Disruptive, Impulse Control, and Conduct Disorders | NA | BeFree | Detail | |
| 0.001 | irritable bowel syndrome | A genetic association study of single nucleotide polymorphisms in GNβ3 and COMT ... | BeFree | 25037115 | Detail |
| 0.001 | irritable bowel syndrome | Conscientiousness is modified by genetic variation in catechol-O-methyltransfera... | BeFree | 25722948 | Detail |
| 0.003 | Kidney Failure, Acute | NA | BeFree,GAD | Detail | |
| 0.003 | Kidney Failure, Chronic | NA | BeFree,GAD | Detail | |
| 0.002 | Kidney Neoplasm | NA | GAD | Detail | |
| 0.005 | Laryngeal neoplasm | NA | GAD | Detail | |
| 0.016 | Fibroid Tumor | Green tea extract inhibition of human leiomyoma cell proliferation is mediated v... | BeFree,GAD,LHGDN | 24942317 | Detail |
| 0.009 | depressive disorder | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
| 0.038 | Mental Depression | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
| <0.001 | Liver diseases | NA | BeFree | Detail | |
| <0.001 | Liver neoplasms | NA | BeFree | Detail | |
| 0.005 | Low Back Pain | NA | BeFree,GAD | Detail | |
| 0.002 | Chronic Obstructive Airway Disease | NA | GAD | Detail | |
| 0.003 | lymphoma | NA | BeFree,GAD | Detail | |
| <0.001 | Lymphoma, Follicular | NA | BeFree | Detail | |
| 0.005 | Lymphoma, Non-Hodgkin | NA | BeFree,GAD | Detail | |
| 0.003 | Mycetoma | NA | BeFree,GAD | Detail | |
| 0.002 | Malignant Carcinoid Syndrome | NA | GAD | Detail | |
| <0.001 | Malignant neoplasm of stomach | NA | BeFree | Detail | |
| 0.122 | Animal Mammary Neoplasms | NA | CTD_human,GAD | Detail | |
| 0.005 | Memory Disorders | NA | GAD | Detail | |
| 0.008 | Mental Retardation | NA | BeFree,GAD | Detail | |
| 0.002 | Mesothelioma | NA | GAD | Detail | |
| 0.002 | Metaplasia | NA | GAD | Detail | |
| 0.178 | attention deficit hyperactivity disorder | We have assessed variants in four genes, DDC (rs3837091 and rs3735273), DRD2 (rs... | BeFree | 24163823 | Detail |
| <0.001 | Dental Fluorosis, Acquired | Modifying effect of COMT gene polymorphism and a predictive role for proteomics ... | BeFree | 25556215 | Detail |
| 0.005 | Mouth Neoplasms | NA | GAD | Detail | |
| 0.002 | Movement Disorders | NA | GAD | Detail | |
| 0.003 | multiple sclerosis | NA | BeFree,GAD | Detail | |
| 0.002 | Musculoskeletal Diseases | NA | GAD | Detail | |
| 0.003 | myocardial infarction | NA | BeFree,GAD | Detail | |
| <0.001 | Narcissism | NA | BeFree | Detail | |
| 0.006 | narcolepsy | NA | BeFree,GAD | Detail | |
| 0.002 | Opioid-Related Disorders | NA | GAD | Detail | |
| 0.002 | Nausea | NA | GAD | Detail | |
| <0.001 | Nausea and vomiting | NA | BeFree | Detail | |
| <0.001 | neonatal abstinence syndrome | NA | BeFree | Detail | |
| 0.038 | Mental Depression | In self-identified white patients with major depressive disorder (N=126) treated... | BeFree | 22727709 | Detail |
| 0.009 | depressive disorder | In self-identified white patients with major depressive disorder (N=126) treated... | BeFree | 22727709 | Detail |
| 0.016 | major depressive disorder | In self-identified white patients with major depressive disorder (N=126) treated... | BeFree | 22727709 | Detail |
| 0.008 | Unipolar Depression | In self-identified white patients with major depressive disorder (N=126) treated... | BeFree | 22727709 | Detail |
| <0.001 | Neuralgia | NA | BeFree | Detail | |
| <0.001 | Neurotic Disorders | NA | BeFree | Detail | |
| 0.002 | nicotine dependence | NA | BeFree | Detail | |
| 0.011 | obesity | NA | BeFree,GAD | Detail | |
| 0.034 | obsessive-compulsive disorder | COMT and MAO-A polymorphisms and obsessive-compulsive disorder: a family-based a... | BeFree,GAD,LHGDN | 25793616 | Detail |
| 0.002 | Occupational Diseases | NA | GAD | Detail | |
| 0.002 | Ocular Motility Disorders | NA | GAD | Detail | |
| 0.003 | oppositional defiant disorder | NA | BeFree,GAD | Detail | |
| 0.002 | Osteoarthritis of hip | NA | GAD | Detail | |
| 0.005 | osteochondritis dissecans | NA | BeFree | Detail | |
| 0.003 | osteoporosis | NA | BeFree,GAD | Detail | |
| <0.001 | Ovarian Diseases | NA | BeFree | Detail | |
| 0.002 | Pain, Intractable | NA | GAD | Detail | |
| 0.009 | Pain, Postoperative | Catechol-o-methyltransferase polymorphisms predict opioid consumption in postope... | BeFree,GAD | 25185591 | Detail |
| 0.162 | panic disorder | NA | BeFree,CTD_human,GAD,LHGDN | Detail | |
| 0.003 | Personality Disorders | NA | BeFree,GAD | Detail | |
| 0.005 | Pharyngeal Neoplasms | NA | GAD | Detail | |
| 0.120 | pheochromocytoma | NA | BeFree,CTD_human | Detail | |
| <0.001 | Pituitary Diseases | NA | BeFree | Detail | |
| 0.002 | Pleural Neoplasms | NA | GAD | Detail | |
| <0.001 | polycystic ovary syndrome | NA | BeFree | Detail | |
| 0.082 | pre-eclampsia | NA | GAD,MGD | Detail | |
| 0.002 | Pregnancy Complications | NA | GAD | Detail | |
| 0.005 | Prenatal Exposure Delayed Effects | NA | GAD | Detail | |
| 0.120 | Prostatic Neoplasms | NA | CTD_human | Detail | |
| 0.005 | Psychoses, Substance-Induced | NA | GAD | Detail | |
| 0.032 | Psychotic Disorders | We have searched for association between 119 SNPs in genes implicated in monoami... | BeFree,GAD,LHGDN | 25073638 | Detail |
| 0.032 | Psychotic Disorders | COMT-by-sex interaction effect on psychosis proneness. | BeFree,GAD,LHGDN | 25722988 | Detail |
| 0.002 | restless legs syndrome | NA | GAD | Detail | |
| 0.001 | schizoaffective disorder | This study examined the catechol-O-methyltransferase (COMT) genotype and its rel... | BeFree | 25139113 | Detail |
| <0.001 | paranoid schizophrenia | NA | BeFree | Detail | |
| <0.001 | Schizophreniform Disorders | NA | BeFree | Detail | |
| <0.001 | Sciatica | NA | BeFree | Detail | |
| 0.002 | Shock | NA | GAD | Detail | |
| 0.005 | Shoulder Pain | NA | BeFree,GAD | Detail | |
| 0.007 | Sleep Deprivation | NA | GAD | Detail | |
| 0.002 | Speech Disorders | NA | GAD | Detail | |
| <0.001 | Stereotyped Behavior | NA | BeFree | Detail | |
| 0.002 | Stomach Neoplasms | NA | GAD | Detail | |
| 0.001 | post-traumatic stress disorder | Race moderates the association of Catechol-O-methyltransferase genotype and post... | BeFree | 25329975 | Detail |
| <0.001 | Stress, Psychological | NA | BeFree | Detail | |
| 0.003 | Subarachnoid Hemorrhage | NA | BeFree,GAD | Detail | |
| <0.001 | Substance Use Disorders | NA | BeFree | Detail | |
| 0.003 | Substance Withdrawal Syndrome | NA | BeFree,GAD | Detail | |
| 0.006 | Temporomandibular Joint Disorders | Abnormalities in the enzymatic activity of catechol-O-methyltransferase (COMT) c... | BeFree,GAD | 25218601 | Detail |
| 0.001 | Temporomandibular Joint Dysfunction Syndrome | Results show that the COMT rs4680 (rs4680>val(158)met) polymorphism is most stro... | BeFree | 25218601 | Detail |
| 0.001 | Temporomandibular Joint Dysfunction Syndrome | Furthermore, a significant (P = 0.04) interaction of COMT diplotype and time-var... | BeFree | 26198390 | Detail |
| 0.002 | Thyroid Neoplasm | NA | GAD | Detail | |
| <0.001 | Tobacco Dependence | NA | BeFree | Detail | |
| 0.017 | Tobacco use disorder | NA | GAD | Detail | |
| 0.003 | Gilles de la Tourette syndrome | Association of Catechol-O-methyltransferase val/met polymorphism with cognitive ... | BeFree,GAD | 25367405 | Detail |
| 0.002 | Uterine Fibroids | The genetic polymorphisms of IVS1+2329C>T and Val158Met loci in COMT, Ile462Val ... | BeFree | 24320736 | Detail |
| 0.002 | Uterine Fibroids | Green tea extract inhibition of human leiomyoma cell proliferation is mediated v... | BeFree | 24942317 | Detail |
| 0.012 | Uterine Neoplasms | NA | GAD | Detail | |
| 0.005 | Venous Thrombosis | NA | GAD,LHGDN | Detail | |
| <0.001 | Vertigo | NA | BeFree | Detail | |
| 0.002 | Violence | NA | BeFree | Detail | |
| 0.008 | vitiligo | NA | BeFree,GAD | Detail | |
| 0.005 | Weight Gain | NA | GAD | Detail | |
| 0.003 | Wolfram syndrome | NA | LHGDN | Detail | |
| 0.005 | Helicobacter Infections | NA | GAD | Detail | |
| 0.101 | Malignant neoplasm of breast | However, when this relation was assessed within strata based on estrogen-related... | BeFree | 22199302 | Detail |
| 0.021 | breast carcinoma | However, when this relation was assessed within strata based on estrogen-related... | BeFree | 22199302 | Detail |
| 0.006 | Mammographic Density | However, when this relation was assessed within strata based on estrogen-related... | BeFree | 22199302 | Detail |
| <0.001 | spina bifida | NA | BeFree | Detail | |
| 0.002 | Bronchial Hyperreactivity | NA | GAD | Detail | |
| <0.001 | seasonal affective disorder | NA | BeFree | Detail | |
| <0.001 | Polydipsia | NA | BeFree | Detail | |
| <0.001 | Apathy | NA | BeFree | Detail | |
| 0.005 | Alcohol abuse | It appears that the COMT Met/Met genotype may be a genetic risk factor that cont... | BeFree,GAD | 24390676 | Detail |
| 0.003 | Depressive Symptoms | Among the men, COMT Val/Val carriers had greater depressive symptom reduction co... | BeFree | 25148110 | Detail |
| <0.001 | Depressive Syndrome | NA | BeFree | Detail | |
| 0.002 | Uterine Fibroids | The genetic polymorphism of rs3087869 (IVS1+2329C>T) (OR 3.200, 95% CI 1.614-... | BeFree | 24777039 | Detail |
| 0.001 | conduct disorder | NA | BeFree | Detail | |
| <0.001 | somatization | NA | BeFree | Detail | |
| 0.002 | Chronic pain | Furthermore, these data suggest that the ability to predict the downstream effec... | BeFree | 25218601 | Detail |
| <0.001 | Central nervous system depression (disorder) | NA | BeFree | Detail | |
| 0.003 | polyneuropathy | NA | LHGDN | Detail | |
| 0.004 | lingual-facial-buccal dyskinesia | NA | BeFree,GAD | Detail | |
| <0.001 | Drug withdrawal syndrome | NA | BeFree | Detail | |
| <0.001 | Disorder of endocrine ovary | NA | BeFree | Detail | |
| 0.002 | migraine with aura | NA | GAD | Detail | |
| <0.001 | Hearing Loss, Mixed Conductive-Sensorineural | NA | BeFree | Detail | |
| 0.003 | Intervertebral Disc Degeneration | NA | BeFree,GAD | Detail | |
| <0.001 | Kleine-Levin syndrome | NA | BeFree | Detail | |
| 0.002 | Amyloid Neuropathies, Familial | NA | GAD | Detail | |
| 0.002 | leiomyomatosis | NA | GAD | Detail | |
| 0.002 | Medullary carcinoma | NA | GAD | Detail | |
| <0.001 | childhood brain tumor | NA | BeFree | Detail | |
| 0.135 | Shprintzen syndrome | Adults with 22q11.2DS were genotyped for a number of COMT polymorphisms as well ... | BeFree,GAD,ORPHANET | 24534796 | Detail |
| 0.135 | Shprintzen syndrome | Nine of ∼30 genes involved in 22qDS have the potential of disrupting mitochondri... | BeFree,GAD,ORPHANET | 26221035 | Detail |
| 0.003 | Depression, Postpartum | NA | BeFree,GAD | Detail | |
| 0.001 | Chronic schizophrenia | NA | BeFree | Detail | |
| <0.001 | Myalgia | NA | BeFree | Detail | |
| <0.001 | Psychological symptom | NA | BeFree | Detail | |
| <0.001 | Psychiatric symptom | We also explored the effect of CCT treatment and COMT genotype on psychiatric sy... | BeFree | 25748092 | Detail |
| <0.001 | Dysphoric mood | NA | BeFree | Detail | |
| <0.001 | Free-floating anxiety | NA | BeFree | Detail | |
| 0.005 | Antisocial behavior | The Val158-allele of the catechol-O-methyltransferase (COMT) rs4680>Val158Met (r... | BeFree,GAD | 25495556 | Detail |
| 0.001 | Memory impairment | NA | BeFree | Detail | |
| 0.012 | Personality Traits | NA | GAD | Detail | |
| <0.001 | Extrapyramidal sign | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of female breast | NA | BeFree | Detail | |
| <0.001 | pancreatic carcinoma | Catechol-O-methyltransferase, a new target for pancreatic cancer therapy. | BeFree | 25711924 | Detail |
| <0.001 | Alcohol withdrawal syndrome | NA | BeFree | Detail | |
| 0.122 | Amphetamine-Related Disorders | NA | CTD_human,GAD | Detail | |
| 0.122 | Cocaine-Related Disorders | NA | CTD_human,GAD | Detail | |
| <0.001 | Bipolar II disorder | A potential interaction between COMT and MTHFR genetic variants in Han Chinese p... | BeFree | 25744938 | Detail |
| 0.012 | Substance-Related Disorders | NA | GAD | Detail | |
| <0.001 | Alcohol or Other Drugs use | Catechol-O-methyltransferase gene methylation and substance use in adolescents: ... | BeFree | 24902721 | Detail |
| <0.001 | Selenium deficiency | NA | BeFree | Detail | |
| <0.001 | Prodrome | NA | BeFree | Detail | |
| 0.013 | Malignant neoplasm of lung | NA | BeFree,GAD | Detail | |
| 0.081 | Parkinsonian Disorders | NA | BeFree,RGD | Detail | |
| 0.002 | Oxidative Stress | NA | GAD | Detail | |
| <0.001 | anxiety generalized | NA | BeFree | Detail | |
| <0.001 | generalized anxiety disorder | NA | BeFree | Detail | |
| <0.001 | Impaired glucose tolerance | NA | BeFree | Detail | |
| <0.001 | Malignant Childhood Neoplasm | NA | BeFree | Detail | |
| <0.001 | Liver and Intrahepatic Biliary Tract Carcinoma | NA | BeFree | Detail | |
| <0.001 | Squamous cell carcinoma of esophagus | NA | BeFree | Detail | |
| <0.001 | Prolapsed lumbar disc | NA | BeFree | Detail | |
| <0.001 | Sexual abuse | NA | BeFree | Detail | |
| <0.001 | Obesity, Abdominal | NA | BeFree | Detail | |
| 0.003 | Common Migraine | Using T1-weighted and resting functional MRI, we evaluated the effect of COMT ge... | BeFree,GAD | 25598522 | Detail |
| 0.003 | Impaired cognition | The COMT allele and genotype were found associated neither with AD onset nor wit... | BeFree | 25012481 | Detail |
| 0.003 | Impaired cognition | Two studies found a positive association between cognitive impairment and the Va... | BeFree | 25458605 | Detail |
| 0.001 | Manic | NA | BeFree | Detail | |
| 0.001 | Mixed anxiety and depressive disorder | NA | BeFree | Detail | |
| <0.001 | endometriosis of uterus | COMT 158G/A and CYP1B1 432C/G polymorphisms increase the risk of endometriosis a... | BeFree | 24965973 | Detail |
| 0.001 | Absence of pain sensation | NA | BeFree | Detail | |
| 0.007 | Malignant neoplasm of liver | NA | BeFree,GAD | Detail | |
| <0.001 | Malignant neoplasm of pancreas | Catechol-O-methyltransferase, a new target for pancreatic cancer therapy. | BeFree | 25711924 | Detail |
| 0.012 | Nonorganic psychosis | COMT-by-sex interaction effect on psychosis proneness. | BeFree | 25722988 | Detail |
| 0.003 | Phobic anxiety disorder | NA | BeFree,GAD | Detail | |
| 0.021 | Malignant neoplasm of prostate | NA | BeFree,GAD | Detail | |
| <0.001 | pain disorder | NA | BeFree | Detail | |
| 0.019 | Congenital diverticulum of pharynx | NA | GAD | Detail | |
| <0.001 | Abnormal involuntary movement | NA | BeFree | Detail | |
| <0.001 | Chronic tension-type headache | NA | BeFree | Detail | |
| <0.001 | Inattention | NA | BeFree | Detail | |
| 0.002 | Physical aggression | NA | GAD | Detail | |
| 0.002 | Response to pain finding | NA | GAD | Detail | |
| 0.001 | Ichthyosis bullosa of Siemens | Conscientiousness is modified by genetic variation in catechol-O-methyltransfera... | BeFree | 25722948 | Detail |
| <0.001 | Chronic low back pain | NA | BeFree | Detail | |
| 0.002 | dyslexia | NA | GAD | Detail | |
| <0.001 | Respiratory distress | NA | BeFree | Detail | |
| 0.004 | dementia | NA | BeFree,GAD | Detail | |
| 0.002 | Premenstrual dysphoric disorder | NA | GAD | Detail | |
| 0.002 | Postoperative Nausea and Vomiting | NA | GAD | Detail | |
| <0.001 | Metabolic syndrome X | NA | BeFree | Detail | |
| <0.001 | Opiate Addiction | NA | BeFree | Detail | |
| <0.001 | Neurodegenerative Disorders | NA | BeFree | Detail | |
| 0.003 | Hepatitis C, Chronic | NA | BeFree,GAD | Detail | |
| 0.002 | Malignant neoplasm of esophagus | NA | GAD | Detail | |
| 0.005 | Menopause present (finding) | NA | GAD | Detail | |
| 0.001 | Cancer pain | NA | BeFree | Detail | |
| 0.002 | Chronic pain | However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental ... | BeFree | 21049025 | Detail |
| 0.004 | Carcinogenesis | Catechol-O-methyltransferase (COMT) is involved in estrogen metabolism and is vi... | BeFree | 25292091 | Detail |
| 0.009 | depressive disorder | Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158... | BeFree | 17941097 | Detail |
| 0.345 | schizophrenia | Interaction between catechol-O-methyltransferase (COMT) Val108/158Met and brain-... | BeFree | 16897602 | Detail |
| 0.017 | Anxiety Disorders | Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxi... | BeFree | 19582565 | Detail |
| 0.001 | Autism Spectrum Disorders | Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxi... | BeFree | 19582565 | Detail |
| <0.001 | Delusions | The methionine variant of Val66Met brain-derived neurotrophic factor BDNF met an... | BeFree | 18596619 | Detail |
| 0.038 | Mental Depression | Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158... | BeFree | 17941097 | Detail |
| 0.002 | hyperhomocysteinemia | NA | GAD | Detail | |
| 0.005 | prostate carcinoma | NA | BeFree,GAD | Detail | |
| 0.003 | Hot flushes | NA | BeFree,GAD | Detail | |
| 0.003 | Heroin Abuse | NA | BeFree,GAD | Detail | |
| <0.001 | cocaine dependence | NA | BeFree | Detail | |
| 0.003 | Epithelial ovarian cancer | NA | BeFree,GAD | Detail | |
| 0.021 | breast carcinoma | NA | BeFree | Detail | |
| <0.001 | Aggressive personality | NA | BeFree | Detail | |
| <0.001 | Carcinoma of lung | NA | BeFree | Detail | |
| 0.002 | Tardive Dyskinesia | NA | BeFree | Detail | |
| <0.001 | Secondary malignant neoplasm of lymph node | NA | BeFree | Detail | |
| <0.001 | Excessive daytime somnolence | NA | BeFree | Detail | |
| <0.001 | colon carcinoma | NA | BeFree | Detail | |
| <0.001 | stomach carcinoma | NA | BeFree | Detail | |
| <0.001 | Carcinoma of bladder | NA | BeFree | Detail | |
| <0.001 | Anxiety state | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of kidney | NA | BeFree | Detail | |
| 0.001 | Substance abuse problem | NA | BeFree | Detail | |
| <0.001 | Premenopausal breast cancer | NA | BeFree | Detail | |
| <0.001 | homicidal | NA | BeFree | Detail | |
| <0.001 | manic symptom | NA | BeFree | Detail | |
| <0.001 | Ovarian failure | COMT polymorphism influences decrease of ovarian follicles and emerges as a pred... | BeFree | 24808926 | Detail |
| <0.001 | Narcolepsy-Cataplexy Syndrome | NA | BeFree | Detail | |
| 0.002 | Vasospasm, Intracranial | NA | GAD | Detail | |
| <0.001 | Chronic Daily Headache | NA | BeFree | Detail | |
| 0.120 | Conotruncal anomaly face syndrome | NA | ORPHANET | Detail | |
| <0.001 | Schizophrenia and related disorders | NA | BeFree | Detail | |
| <0.001 | psychological distress | NA | BeFree | Detail | |
| <0.001 | perfectionism | NA | BeFree | Detail | |
| 0.002 | Sleep Disorders | NA | GAD | Detail | |
| 0.001 | bipolar I disorder | NA | BeFree | Detail | |
| <0.001 | Invasive breast carcinoma | NA | BeFree | Detail | |
| <0.001 | Impulsive aggression | NA | BeFree | Detail | |
| <0.001 | Carcinogenicity | NA | BeFree | Detail | |
| <0.001 | social stress | NA | BeFree | Detail | |
| <0.001 | Treatment related secondary malignancy | NA | BeFree | Detail | |
| 0.002 | Genomic Instability | NA | GAD | Detail | |
| <0.001 | Ischemic stroke | NA | BeFree | Detail | |
| 0.002 | Acute coronary syndrome | NA | GAD | Detail | |
| <0.001 | Non-small cell lung carcinoma | When we corrected for multiple testing using these statistical tools, three nove... | BeFree | 18258609 | Detail |
| <0.001 | Mild cognitive disorder | NA | BeFree | Detail | |
| <0.001 | Chronic pain syndrome | NA | BeFree | Detail | |
| <0.001 | Generalized vitiligo | NA | BeFree | Detail | |
| <0.001 | Hereditary Nonpolyposis Colorectal Cancer | NA | BeFree | Detail | |
| <0.001 | Sporadic Breast Carcinoma | NA | BeFree | Detail | |
| 0.002 | Testicular Germ Cell Tumor | NA | GAD | Detail | |
| <0.001 | renal carcinoma | NA | BeFree | Detail | |
| <0.001 | Cognitive changes | NA | BeFree | Detail | |
| <0.001 | Attention deficit-hyperactivity | NA | BeFree | Detail | |
| <0.001 | Ovarian Insufficiency | COMT polymorphism influences decrease of ovarian follicles and emerges as a pred... | BeFree | 24808926 | Detail |
| 0.003 | Methamphetamine abuse | NA | BeFree,GAD | Detail | |
| <0.001 | Paranoia | NA | BeFree | Detail | |
| 0.144 | Mammary Neoplasms | NA | CTD_human,GAD,LHGDN | Detail | |
| 0.001 | Autism Spectrum Disorders | Association between autism spectrum disorder in individuals with velocardiofacia... | BeFree | 25325218 | Detail |
| <0.001 | Xenograft Model | The COMT overexpressed and silenced cell lines showed significantly inhibited an... | BeFree | 25711924 | Detail |
| 0.008 | colorectal cancer | Catechol-O-methyltransferase inhibits colorectal cancer cell proliferation and i... | BeFree,GAD | 25532943 | Detail |
| 0.002 | Cirrhosis | NA | GAD | Detail | |
| <0.001 | Benign Prostatic Hyperplasia | NA | BeFree | Detail | |
| 0.001 | TIBIAL MUSCULAR DYSTROPHY, TARDIVE | Results show that the COMT rs4680 (rs4680>val(158)met) polymorphism is most stro... | BeFree | 25218601 | Detail |
| 0.001 | TIBIAL MUSCULAR DYSTROPHY, TARDIVE | Furthermore, a significant (P = 0.04) interaction of COMT diplotype and time-var... | BeFree | 26198390 | Detail |
| 0.004 | MAJOR AFFECTIVE DISORDER 2 | NA | BeFree,GAD | Detail | |
| 0.005 | NEUROTICISM | NA | BeFree,GAD | Detail | |
| 0.006 | Mammographic Density | NA | BeFree,GAD | Detail | |
| <0.001 | VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | NA | BeFree | Detail | |
| <0.001 | COGNITIVE FUNCTION 1, SOCIAL | NA | BeFree | Detail | |
| 0.004 | MAJOR AFFECTIVE DISORDER 1 | NA | BeFree,GAD | Detail | |
| 0.005 | PANIC DISORDER 1 | NA | BeFree | Detail | |
| 0.002 | uterine corpus cancer | NA | BeFree | Detail | |
| <0.001 | coronary artery disease | NA | BeFree | Detail | |
| 0.004 | MAJOR AFFECTIVE DISORDER 4 | NA | BeFree,GAD | Detail | |
| 0.004 | MAJOR AFFECTIVE DISORDER 5 | NA | BeFree,GAD | Detail | |
| 0.004 | MAJOR AFFECTIVE DISORDER 6 | NA | BeFree,GAD | Detail | |
| <0.001 | Acute postoperative pain | NA | BeFree | Detail | |
| 0.121 | liver carcinoma | NA | BeFree,CTD_human | Detail | |
| 0.002 | Maduromycosis | NA | GAD | Detail | |
| 0.004 | Major affective disorder 7 | NA | BeFree,GAD | Detail | |
| 0.004 | MAJOR AFFECTIVE DISORDER 8 | NA | BeFree,GAD | Detail | |
| 0.004 | MAJOR AFFECTIVE DISORDER 9 | NA | BeFree,GAD | Detail | |
| <0.001 | Stimulant dependence | NA | BeFree | Detail | |
| <0.001 | Executive dysfunction | NA | BeFree | Detail | |
| 0.240 | HEARING LOSS, CISPLATIN-INDUCED, SUSCEPTIBILITY TO | NA | CTD_human,ORPHANET | Detail | |
| 0.002 | Weight Loss Adverse Event | NA | GAD | Detail | |
| 0.005 | Weight Gain Adverse Event | NA | GAD | Detail | |
| 0.124 | 22q11 Deletion Syndrome | Catechol-O-methyltransferase (COMT), a positional candidate gene for schizophren... | BeFree,GAD,ORPHANET | 24534796 | Detail |
| <0.001 | headache severe | NA | BeFree | Detail | |
| <0.001 | Nociceptive Pain | NA | BeFree | Detail | |
| 0.120 | 22q11 partial monosomy syndrome | NA | ORPHANET | Detail | |
| <0.001 | Ischemic Cerebrovascular Accident | NA | BeFree | Detail | |
| <0.001 | Dowling-Degos disease | NA | BeFree | Detail | |
| 0.003 | adenocarcinoma | NA | BeFree,GAD | Detail | |
| 0.001 | Affective Disorders, Psychotic | NA | BeFree | Detail | |
| <0.001 | Alcohol Withdrawal Delirium | NA | BeFree | Detail | |
| 0.157 | Alcoholic Intoxication, Chronic | This study provides data from a sample of ethnically homogeneous unrelated Cauca... | BeFree,CTD_human,GAD,LHGDN | 25035107 | Detail |
| 0.003 | alexithymia | NA | BeFree,GAD | Detail | |
| 0.026 | Alzheimer's disease | Association study of two steroid biosynthesis genes (COMT and CYP17) with Alzhei... | BeFree,GAD,LHGDN | 25012481 | Detail |
| 0.026 | Alzheimer's disease | In each case, a single gene is represented in a plurality of epistatic interacti... | BeFree,GAD,LHGDN | 25403528 | Detail |
| <0.001 | Anaplasia | COMT polymorphism and memory dedifferentiation in old age. | BeFree | 23834492 | Detail |
| <0.001 | Anorexia | NA | BeFree | Detail | |
| 0.012 | anorexia nervosa | NA | BeFree,GAD,LHGDN | Detail | |
| 0.002 | Anxiety | NA | GAD | Detail | |
| <0.001 | arteriosclerosis | NA | BeFree | Detail | |
| 0.002 | Arthralgia | NA | GAD | Detail | |
| 0.012 | As If Personality | NA | GAD | Detail | |
| 0.003 | atherosclerosis | NA | BeFree,GAD | Detail | |
| 0.125 | autistic disorder | NA | BeFree,CTD_human,GAD | Detail | |
| <0.001 | Behavior Disorders | NA | BeFree | Detail | |
| <0.001 | Depression, Bipolar | NA | BeFree | Detail | |
| 0.008 | Malignant neoplasm of urinary bladder | NA | BeFree,GAD | Detail | |
| 0.003 | Bladder Neoplasm | NA | LHGDN | Detail | |
| 0.002 | borderline personality disorder | Because dopaminergic disturbance is thought to be involved in the development of... | BeFree | 25744938 | Detail |
| 0.101 | Malignant neoplasm of breast | NA | BeFree,GAD | Detail | |
| 0.002 | bronchopulmonary dysplasia | Because dopaminergic disturbance is thought to be involved in the development of... | BeFree | 25744938 | Detail |
| 0.003 | Bulimia | NA | BeFree,GAD | Detail | |
| <0.001 | cannabis abuse | NA | BeFree | Detail | |
| <0.001 | Malignant tumor of colon | NA | BeFree | Detail | |
| 0.002 | Malignant neoplasm of endometrium | NA | BeFree | Detail | |
| <0.001 | female breast carcinoma | NA | BeFree | Detail | |
| <0.001 | Rectal Carcinoma | NA | BeFree | Detail | |
| <0.001 | Non-small cell lung carcinoma | NA | BeFree | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Catechol-O-methyltransferase inhibits colorectal cancer cell proliferation and invasion. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Brooding rumination and heart rate variability in women at high and low risk for depression: group d... | DisGeNET | Detail |
| An interaction with catechol-O-methyltransferase (COMT) has also been proved affecting depression. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Brooding rumination and heart rate variability in women at high and low risk for depression: group d... | DisGeNET | Detail |
| An interaction with catechol-O-methyltransferase (COMT) has also been proved affecting depression. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In contrast, compared with control subjects, COMT 158Met was significantly more prevalent in the IBS... | DisGeNET | Detail |
| Nine of ∼30 genes involved in 22qDS have the potential of disrupting mitochondrial metabolism (COMT,... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Our findings suggest that polymorphisms in COMT and MAO-B may increase the risk of wearing-off and d... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| COMT 158G/A and CYP1B1 432C/G polymorphisms increase the risk of endometriosis and adenomyosis: a me... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Our results suggest that PRODH and COMT may interact to contribute to the ASD phenotype in individua... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| A genetic association study of single nucleotide polymorphisms in GNβ3 and COMT in elderly patients ... | DisGeNET | Detail |
| Conscientiousness is modified by genetic variation in catechol-O-methyltransferase to reduce symptom... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Green tea extract inhibition of human leiomyoma cell proliferation is mediated via catechol-O-methyl... | DisGeNET | Detail |
| To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
| To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We have assessed variants in four genes, DDC (rs3837091 and rs3735273), DRD2 (rs1800496, rs1801028, ... | DisGeNET | Detail |
| Modifying effect of COMT gene polymorphism and a predictive role for proteomics analysis in children... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In self-identified white patients with major depressive disorder (N=126) treated with open-label dul... | DisGeNET | Detail |
| In self-identified white patients with major depressive disorder (N=126) treated with open-label dul... | DisGeNET | Detail |
| In self-identified white patients with major depressive disorder (N=126) treated with open-label dul... | DisGeNET | Detail |
| In self-identified white patients with major depressive disorder (N=126) treated with open-label dul... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| COMT and MAO-A polymorphisms and obsessive-compulsive disorder: a family-based association study. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Catechol-o-methyltransferase polymorphisms predict opioid consumption in postoperative pain. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We have searched for association between 119 SNPs in genes implicated in monoaminergic pathways [try... | DisGeNET | Detail |
| COMT-by-sex interaction effect on psychosis proneness. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| This study examined the catechol-O-methyltransferase (COMT) genotype and its relationship to cogniti... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Race moderates the association of Catechol-O-methyltransferase genotype and posttraumatic stress dis... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Abnormalities in the enzymatic activity of catechol-O-methyltransferase (COMT) contribute to chronic... | DisGeNET | Detail |
| Results show that the COMT rs4680 (rs4680>val(158)met) polymorphism is most strongly associated with... | DisGeNET | Detail |
| Furthermore, a significant (P = 0.04) interaction of COMT diplotype and time-varying stress showed t... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association of Catechol-O-methyltransferase val/met polymorphism with cognitive function in Gilles d... | DisGeNET | Detail |
| The genetic polymorphisms of IVS1+2329C>T and Val158Met loci in COMT, Ile462Val and Gly45Asp loci in... | DisGeNET | Detail |
| Green tea extract inhibition of human leiomyoma cell proliferation is mediated via catechol-O-methyl... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... | DisGeNET | Detail |
| However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... | DisGeNET | Detail |
| However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| It appears that the COMT Met/Met genotype may be a genetic risk factor that contributes to the devel... | DisGeNET | Detail |
| Among the men, COMT Val/Val carriers had greater depressive symptom reduction compared with Met/Met ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The genetic polymorphism of rs3087869 (IVS1+2329C>T) (OR 3.200, 95% CI 1.614-6.345) and rs4680 (V... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Furthermore, these data suggest that the ability to predict the downstream effects of genetic variat... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Adults with 22q11.2DS were genotyped for a number of COMT polymorphisms as well as the Ashkenazi ris... | DisGeNET | Detail |
| Nine of ∼30 genes involved in 22qDS have the potential of disrupting mitochondrial metabolism (COMT,... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We also explored the effect of CCT treatment and COMT genotype on psychiatric symptom severity, func... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The Val158-allele of the catechol-O-methyltransferase (COMT) rs4680>Val158Met (rs4680) functional po... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Catechol-O-methyltransferase, a new target for pancreatic cancer therapy. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Catechol-O-methyltransferase gene methylation and substance use in adolescents: the TRAILS study. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Using T1-weighted and resting functional MRI, we evaluated the effect of COMT genetic variations on ... | DisGeNET | Detail |
| The COMT allele and genotype were found associated neither with AD onset nor with parameters of AD s... | DisGeNET | Detail |
| Two studies found a positive association between cognitive impairment and the Val allele of the COMT... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| COMT 158G/A and CYP1B1 432C/G polymorphisms increase the risk of endometriosis and adenomyosis: a me... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Catechol-O-methyltransferase, a new target for pancreatic cancer therapy. | DisGeNET | Detail |
| COMT-by-sex interaction effect on psychosis proneness. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Conscientiousness is modified by genetic variation in catechol-O-methyltransferase to reduce symptom... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated ... | DisGeNET | Detail |
| Catechol-O-methyltransferase (COMT) is involved in estrogen metabolism and is vital to estrogen-indu... | DisGeNET | Detail |
| Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-deriv... | DisGeNET | Detail |
| Interaction between catechol-O-methyltransferase (COMT) Val108/158Met and brain-derived neurotrophic... | DisGeNET | Detail |
| Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics i... | DisGeNET | Detail |
| Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics i... | DisGeNET | Detail |
| The methionine variant of Val66Met brain-derived neurotrophic factor BDNF met and catecholamine-O-me... | DisGeNET | Detail |
| Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-deriv... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| COMT polymorphism influences decrease of ovarian follicles and emerges as a predictive factor for pr... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| When we corrected for multiple testing using these statistical tools, three novel associations of NS... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| COMT polymorphism influences decrease of ovarian follicles and emerges as a predictive factor for pr... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association between autism spectrum disorder in individuals with velocardiofacial (22q11.2 deletion)... | DisGeNET | Detail |
| The COMT overexpressed and silenced cell lines showed significantly inhibited and enhanced growth ca... | DisGeNET | Detail |
| Catechol-O-methyltransferase inhibits colorectal cancer cell proliferation and invasion. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Results show that the COMT rs4680 (rs4680>val(158)met) polymorphism is most strongly associated with... | DisGeNET | Detail |
| Furthermore, a significant (P = 0.04) interaction of COMT diplotype and time-varying stress showed t... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Catechol-O-methyltransferase (COMT), a positional candidate gene for schizophrenia, resides within t... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| This study provides data from a sample of ethnically homogeneous unrelated Caucasian subjects for fu... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association study of two steroid biosynthesis genes (COMT and CYP17) with Alzheimer's disease in the... | DisGeNET | Detail |
| In each case, a single gene is represented in a plurality of epistatic interactions, apolipoprotein ... | DisGeNET | Detail |
| COMT polymorphism and memory dedifferentiation in old age. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Because dopaminergic disturbance is thought to be involved in the development of bipolar disorder (B... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Because dopaminergic disturbance is thought to be involved in the development of bipolar disorder (B... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- dbSNP
- rs1065827 dbSNP
- Genome
- hg38
- Position
- chr22:19,941,371-19,969,975
- Variant Type
- snv
Genome browser