restless legs syndrome
Information
- Disease name
- restless legs syndrome
- Disease ID
- DOID:0050425
- Description
- "A central nervous system disease characterized by throbbing, pulling creeping or other unpleasant sensations in the legs and the irresistible urge to move them." [url:http\://en.wikipedia.org/wiki/Restless_legs_syndrome, url:http\://www.ninds.nih.gov/disorders/restless_legs/detail_restless_legs.htm]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03834792 | Active, not recruiting | Adverse Long-term Consequences of Sleep Disordered Breathing: The Ottawa Hospital (TOH) Sleep Database | December 30, 2018 | December 2028 | |
| NCT05007743 | Active, not recruiting | N/A | Effects of Transcutaneous Vagus Nerve Stimulation in Chronic Pain Patients and Healthy Controls | July 21, 2019 | August 2023 |
| NCT00133198 | Completed | Phase 3 | Efficacy and Safety of Pramipexole Compared to Placebo in the Treatment of Restless Legs Syndrome (RLS) | April 2004 | February 2005 |
| NCT00135993 | Completed | Phase 3 | Four Different Transdermal Doses of Rotigotine in Subjects With Idiopathic Restless Legs Syndrome | May 2005 | November 2006 |
| NCT00136045 | Completed | Phase 3 | Three Different Transdermal Doses of Rotigotine in Subjects With Idiopathic Restless Leg Syndrome | May 2005 | August 2006 |
| NCT00140712 | Completed | Phase 1 | Ropinirole Tablets In Young Patients With Restless Legs Syndrome | June 10, 2005 | February 28, 2008 |
| NCT00144209 | Completed | Phase 3 | Assess Efficacy and Safety of the Dopamine Agonist Pramipexole Versus Levodopa / Benserazide (Madopar® DR) in Patients With Restless Legs Syndrome | February 2003 | February 2005 |
| NCT00152958 | Completed | Phase 3 | A Study in Patients Suffering From Idiopathic Restless Legs Syndrome Who Responded to a Preceding, 6-month Treatment With Open-label Pramipexole Including Titration (0.125, 0.25, 0.5, 0.75 mg Orally q.n.) | January 2004 | |
| NCT00152997 | Completed | Phase 2 | Pramipexole (BI-Sifrol®) Orally Once Daily for 6 Weeks in Patients With Primary Restless Legs Syndrome | August 2004 | |
| NCT00197080 | Completed | Phase 3 | Ropinirole XR (Extended Release) In Patients With Restless Legs Syndrome | June 2005 | January 2006 |
| NCT00199446 | Completed | Phase 2 | Study of Istradefylline (KW-6002) for the Treatment of Restless Legs Syndrome | July 2005 | October 2006 |
| NCT00200941 | Completed | Phase 4 | Efficacy and Safety Study of Topiramate to Treat Restless Legs Syndrome | August 2001 | April 2005 |
| NCT00207285 | Completed | N/A | Sleep Disorders Management, Health and Safety in Police | May 2005 | September 2010 |
| NCT00225862 | Completed | Phase 3 | A Clinical Research Study Evaluating Ropinirole Treatment For Restless Legs Syndrome (RLS) | January 2005 | December 2005 |
| NCT00239486 | Completed | Phase 2 | Dose Finding Study of Pramipexole (Sifrol) in Patients With Idiopathic Restless Legs Syndrome (RLS) | October 2002 | April 2004 |
| NCT00246051 | Completed | N/A | Comprehensive Police Fatigue Management Program | November 2005 | December 2010 |
| NCT00247364 | Completed | Phase 2 | A Double Blind Crossover Trial of Levetiracetam (Keppra®) and Placebo in the Treatment of Restless Legs Syndrome (RLS) | November 2003 | October 2005 |
| NCT00256854 | Completed | Phase 3 | Converting From Ropinirole Immediate Release (IR) To Ropinirole Controlled-Release for RLS (Restless Legs Syndrome) | November 14, 2005 | September 21, 2006 |
| NCT00263068 | Completed | Phase 3 | An Extension Trial to Investigate Long-Term Treatment With Transdermal Rotigotine in Idiopathic Restless Legs Syndrome | December 2005 | December 2007 |
| NCT00275236 | Completed | Phase 3 | A Sleep Lab Trial to Investigate the Efficacy and Safety of Transdermal Rotigotine in Subjects With Idiopathic Restless Legs Syndrome | November 2005 | July 2006 |
| NCT00275457 | Completed | Phase 3 | Efficacy and Safety of Pramipexole (PPX) in Moderate to Severe Idiopathic Restless Legs Syndrome (RLS) Patients | October 2002 | April 2004 |
| NCT00298623 | Completed | Phase 3 | XP13512 (GSK1838262) Versus Placebo in Patients With Restless Legs Syndrome. | March 2006 | February 2007 |
| NCT00311363 | Completed | Phase 3 | Long-Term Study of Gabapentin Enacarbil (GEn, XP13512) vs. Placebo in Patients With Restless Legs Syndrome. | April 2006 | November 2007 |
| NCT00314860 | Completed | Phase 3 | RLS In Adults: Comparing Immediate Release Formulation With Extended Release Formulation Of Ropinirole | February 2006 | December 2006 |
| NCT00329602 | Completed | Phase 4 | Long-term Study Of Ropinirole In Restless Legs Syndrome | March 2006 | September 2008 |
| NCT00333359 | Completed | Phase 3 | XP13512 (Gabapentin Enacarbil) Extension Study in Patients With Restless Legs Syndrome. | June 2006 | December 2008 |
| NCT00344994 | Completed | Phase 4 | SWITCH:Restless Legs Patients Switched to Ropinirole From Pramipexole | May 2006 | April 2010 |
| NCT00349531 | Completed | Phase 4 | A Phase IV Trial With Pramipexole to Investigate the Effects on RLS Symptoms and Sleep Disturbance in Patients With RLS | July 2006 | |
| NCT00355641 | Completed | Phase 3 | Long-Term Safety Of Ropinirole XR In Patients With Restless Legs Syndrome | October 2005 | October 2007 |
| NCT00356096 | Completed | Phase 4 | Phase IV Trial With Pramipexole to Evaluate Safety and Efficacy in Patients With RLS Associated With Mood Disturbances | July 2006 | |
| NCT00357097 | Completed | Phase 3 | The Effects Of Ropinirole On Mood Or Mild Depression In Patients With Moderate To Severe Restless Legs Syndrome | June 2006 | December 2007 |
| NCT00363857 | Completed | Phase 3 | A Clinical Research Study Testing Ropinirole Treatment for Restless Legs Syndrome | August 2003 | May 2004 |
| NCT00365352 | Completed | Phase 3 | XP13512 vs. Placebo in Patients With Restless Legs Syndrome. | August 2006 | December 2007 |
| NCT00367822 | Completed | Phase 3 | Transdermal Lisuride: a Trial for the Treatment of Patients With Restless Legs Syndrome (RLS) | ||
| NCT00373542 | Completed | Phase 4 | 12-week Polysomnography Study of Ropinirole Controlled Release for Restless Legs Syndrome | October 2006 | June 2007 |
| NCT00375284 | Completed | Phase 4 | A 6 Week Trial to Study the Efficacy and Safety of a Starting Dose 0.25 mg Pramipexole (Mirapex) in Patients With RLS | September 2006 | |
| NCT00389831 | Completed | Phase 2 | Efficacy, Safety and Tolerability of Rotigotine Nasal Spray for the Acute Treatment of RLS Symptoms | August 2006 | December 2006 |
| NCT00419692 | Completed | Phase 1 | Restless Legs Patient Study On Absorption, Distribution, Metabolism And Excretion Of Ropinirole And The Effect Of Food | August 24, 2006 | December 12, 2006 |
| NCT00422994 | Completed | Phase 1 | A Study To Investigate The Effects Of End Stage Renal Disease And Hemodialysis On The Pharmacokinetics Of Ropinirole | April 2006 | December 2006 |
| NCT00472199 | Completed | Phase 4 | Long-term Efficacy, Safety and Tolerability of Pramipexole in Patients With Idiopathic Moderate to Severe Restless Legs Syndrome (RLS) | May 2007 | |
| NCT00479154 | Completed | Phase 1/Phase 2 | Botulinum Toxin to Treat Restless Legs Syndrome | May 2007 | April 2008 |
| NCT00479531 | Completed | Phase 3 | Sequential Compression Devices for Treatment of Restless Legs Syndrome | September 2005 | October 2007 |
| NCT00498186 | Completed | Phase 2 | Long-term Open-label Trial in Idiopathic Restless Legs Syndrome (RLS) | July 2003 | April 2009 |
| NCT00530530 | Completed | Phase 2 | ASP8825 - Study in Patients With Restless Legs Syndrome | September 2007 | January 2009 |
| NCT00530790 | Completed | Phase 2 | Clinical Evaluation of Ropinirole CR-RLS ( SK&F101468)Tablets in Restless Legs Syndrome | August 23, 2007 | February 1, 2008 |
| NCT00539461 | Completed | Non-interventional Observational Study of Pramipexole in Restless Legs Syndrome: Impact on Quality of Life | February 2007 | ||
| NCT00557258 | Completed | Cross-Sectional Study: Prevalence of Restless Legs Syndrome in Patients With Unpleasant Sensations of the Legs | November 2007 | ||
| NCT00621517 | Completed | Phase 2/Phase 3 | Bupropion and Restless Legs Syndrome | February 2008 | July 2009 |
| NCT00625547 | Completed | Phase 3 | A Study to Determine the Efficacy and Safety of Cabergoline for the Treatment of Patients With RLS | January 2003 | December 2004 |
| NCT00626418 | Completed | Phase 2 | The Effects of Aplindore on the Treatment of Signs and Symptoms of Restless Legs Syndrome | February 2008 | |
| NCT00627003 | Completed | Phase 3 | A Study to Evaluate the Efficacy and Safety of Cabergoline Compared With Placebo for the Treatment of RLS | November 2002 | May 2003 |
| NCT00654498 | Completed | Phase 3 | Pramipexole in Out-patients With Idiopathic Restless Legs Syndrome (IRLS) | April 2008 | June 2009 |
| NCT06324760 | Completed | Alpha-lipoic Acid Combined With B Vitamins Shows Promise for Treating Restless Legs Syndrome | March 4, 2020 | June 2, 2021 | |
| NCT00074672 | Completed | Relationship Between Sensory and Motor Systems in Restless Leg Syndrome | December 12, 2003 | April 14, 2009 | |
| NCT01537042 | Completed | Phase 3 | A Sleep Laboratory Study to Investigate the Safety and Efficacy of the Rotigotine Skin Patch in Subjects With Restless Legs Syndrome and End-Stage Renal Disease Requiring Hemodialysis | April 2012 | October 2013 |
| NCT01569464 | Completed | Phase 3 | Rotigotine Effect on All-day Functioning and Quality of Life in Subjects With Moderate to Severe Restless Legs Syndrome (RLS) | March 2012 | April 2013 |
| NCT01633151 | Completed | Validation Study for an Unobtrusive Online Sleep Measurement System | June 2012 | September 2013 | |
| NCT01668667 | Completed | Phase 4 | Gabapentin Enacarbil (GSK1838262) Adult Restless Leg Syndrome (RLS) Post Marketing Commitment Study | June 2012 | November 2013 |
| NCT01675323 | Completed | Glutamate, Hyperarousal and Restless Legs Syndrome | August 2012 | July 2016 | |
| NCT01887613 | Completed | Specified Drug Use-Results Survey of Regnite | October 1, 2012 | February 28, 2019 | |
| NCT01967303 | Completed | Restless Legs Syndrome in Stroke Patients | January 2008 | December 2008 | |
| NCT01976871 | Completed | Phase 4 | Switching From Oral Dopamine Agonists to Rotigotine | August 2014 | December 2015 |
| NCT02011191 | Completed | N/A | Biotin Deficiency and Restless Legs Syndrome | December 2006 | December 2008 |
| NCT02025608 | Completed | Phase 4 | Autonomic Function and Cardiovascular Risk in Restless Legs Syndrome | December 2013 | December 31, 2016 |
| NCT02231918 | Completed | Phase 2 | Study to Investigate Pharmacokinetics (PK) of Pramipexole in Pediatric Patients Who Are Individually Optimized to Stable Pramipexole Doses for the Treatment of Idiopathic Restless Legs Syndrome (RLS) | May 2006 | |
| NCT02248142 | Completed | Observational Study of Sifrol® in Patients With Primary Restless Legs Syndrome (RLS) | February 2006 | ||
| NCT02248155 | Completed | Observational Study of Sifrol® in Patients With Primary Restless Legs Syndrome (RLS) | April 2006 | ||
| NCT02499354 | Completed | Phase 2 | Pilot Study: Randomized, Placebo-controlled Comparator Trial of IV vs Oral Iron Treatment of RLS With IDA. (IVOR-IDA) | August 2014 | May 31, 2022 |
| NCT02526277 | Completed | N/A | A Study on the Use of the MMF07 Foot Massager and Heat Therapy Treatments for Restless Leg Syndrome | January 6, 2016 | September 25, 2018 |
| NCT02532608 | Completed | N/A | Infra-slow Oscillations During Sleep | October 2015 | August 2017 |
| NCT02559739 | Completed | Sleep Deficiency and Stroke Outcome | July 2015 | March 2022 | |
| NCT02642315 | Completed | N/A | The Effect of Horizant (Gabapentin Enacarbil) on Augmentation | January 2016 | May 6, 2019 |
| NCT02658188 | Completed | Phase 3 | Long-term Efficacy and Safety of Gabapentin Enacarbil in Japanese Restless Legs Syndrome Patients | December 2007 | April 2009 |
| NCT03076541 | Completed | Cardiovascular Variability, Heart Rate Response, and Electromyogram Power Associated With Periodic Leg Movements. | September 1, 2016 | March 2017 | |
| NCT03249779 | Completed | N/A | Treatment of RLS/WED Symptoms Through Sensory Counter-stimulation | December 2016 | June 2018 |
| NCT03457571 | Completed | Clinical Observational Study: IBD Patients With Restless-legs-syndrome and Iron Deficiency Syndrome | February 1, 2014 | April 30, 2015 | |
| NCT03539081 | Completed | N/A | Spinal Cord Stimulation for Restless Legs Syndrome | July 5, 2016 | April 23, 2020 |
| NCT03570515 | Completed | N/A | Yoga vs. Education for Restless Legs Syndrome: a Feasibility Study | February 15, 2015 | August 15, 2021 |
| NCT03806530 | Completed | Phase 3 | DIalysis Symptom COntrol-Restless Legs Syndrome Trial | May 1, 2019 | July 19, 2022 |
| NCT04061681 | Completed | N/A | Efficacy of BIPAMS for Restless Legs Syndrome in Adults With Multiple Sclerosis: A Pilot Study | January 1, 2020 | November 23, 2020 |
| NCT04141891 | Completed | N/A | Advancing Understanding of Transportation Options | December 12, 2019 | December 21, 2023 |
| NCT04161027 | Completed | Phase 3 | RCT for Pregabalin in Restless Legs Syndrome in South Korea | February 24, 2020 | April 4, 2022 |
| NCT04316052 | Completed | N/A | Aerobic And Strength Training Exercises For Restless Leg Syndrome In Patients With Diabetes | February 15, 2020 | February 15, 2021 |
| NCT04698343 | Completed | N/A | Noninvasive Peripheral Nerve Stimulation for Restless Legs Syndrome During Opioid Medication Reduction | April 6, 2021 | March 28, 2023 |
| NCT04700683 | Completed | N/A | Noninvasive Peripheral Nerve Stimulation for Restless Legs Syndrome | July 14, 2019 | March 1, 2020 |
| NCT04706091 | Completed | Phase 4 | Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia | August 12, 2021 | October 20, 2023 |
| NCT04711993 | Completed | N/A | Investigation of the Effects of Different Exercise Programs in Patients With Restless Legs Syndrome. | February 17, 2021 | September 17, 2022 |
| NCT04827329 | Completed | Anesthetic Management of Patients With Chronic Sleep Disorders | March 1, 2021 | July 1, 2021 | |
| NCT04853771 | Completed | N/A | The Effect of Progressive Muscle Relaxation Exercise Training Given to Pregnant Women With Restless Leg Syndrome | April 6, 2021 | December 24, 2021 |
| NCT04874155 | Completed | N/A | Noninvasive Peripheral Nerve Stimulation for Medication-Refractory Primary RLS (The RESTFUL Study) | May 6, 2021 | April 8, 2022 |
| NCT04887103 | Completed | N/A | The Effect of Hot Water Application in Pregnant Women With Restless Legs Syndrome: A Randomised Controlled Study | October 16, 2018 | April 8, 2019 |
| NCT04906486 | Completed | Autonomic Assessment in Patients With Restless Legs Syndrome | November 12, 2020 | April 12, 2021 | |
| NCT05196828 | Completed | N/A | Extension Study Evaluating NTX100 Neuromodulation System for Medication-Refractory Primary RLS | December 20, 2021 | November 18, 2022 |
| NCT05214963 | Completed | N/A | Noninvasive Peripheral Nerve Stimulation for Medication-Naive and Medication-Refractory RLS | March 8, 2022 | October 24, 2023 |
| NCT05698420 | Completed | Investigation of the Effects of Medium Cut-off Dialyzers Versus High-Flux Dialyzers on Clinical and Laboratory Parameters of Prevalent Hemodialysis Patients | March 1, 2020 | October 31, 2020 | |
| NCT05787080 | Completed | N/A | Massage, Oxidative and Antioxidant Enzymes in Hemodialysis Patients With Restless Legs Syndrome(RLS) | September 1, 2023 | January 1, 2024 |
| NCT05795868 | Completed | N/A | The Effect of Compression Stockings on the Complaints of Pregnant Women With Restless Leg Syndrome | April 25, 2022 | March 20, 2023 |
| NCT05851001 | Completed | N/A | Effects of Progressive Muscle Relaxation Exercises During Pregnancy | April 1, 2016 | June 1, 2019 |
| NCT00051961 | Completed | Effect of Ropinirole on Spinal Cord Reflexes and Restless Legs Syndrome | January 14, 2003 | October 18, 2007 | |
| NCT00676403 | Completed | Phase 2 | Lyrica Dose Response Study With Restless Legs Syndrome (RLS) Patients | April 2008 | January 2009 |
| NCT00721279 | Completed | Sifrol (Pramipexole) Onset of Action and Impact: a 12-weeks Observational Study in Patients With Primary Restless Legs Syndrome | September 2007 | ||
| NCT00748098 | Completed | Phase 3 | Polysomnography Study of GSK1838262 Extended Release Tablets Versus Placebo in RLS and Associated Sleep Disturbance | October 2008 | July 2009 |
| NCT00867893 | Completed | Suggested Immobilization Test (SIT) Test for Early Detection of Restless Legs Syndrome (RLS) Augmentation - Proof of Concept | February 2009 | July 2012 | |
| NCT00887289 | Completed | Non-interventional Observational Study on the Influence of Pramipexole on Sensory Symptoms of Restless Legs Syndrome (RLS) | April 2009 | October 2009 | |
| NCT00895232 | Completed | Phase 2 | Iron Sucrose In The Treatment of Restless Legs Syndrome: Safety of Three Dose Regimens as Evaluated by Clinical Assessments | November 2003 | November 2005 |
| NCT00942253 | Completed | Phase 2 | Exercise Training in Dialysis Patients With Restless Legs Syndrome (RLS) | September 2006 | July 2010 |
| NCT00949806 | Completed | Phase 2 | Restless Legs Syndrome Treatment With Botulinum Toxin | August 2009 | November 2011 |
| NCT00991276 | Completed | Phase 3 | Polysomnography Study Of Pregabalin And Pramipexole Versus Placebo In Patients With Restless Legs Syndrome And Associated Sleep Disturbance | December 2009 | June 2011 |
| NCT01109537 | Completed | Altered Brain GABA and Glutamate in Restless Legs Syndrome | April 2010 | May 2014 | |
| NCT01125033 | Completed | Phase 2/Phase 3 | Study of Vitamin C, Vitamin E and Their Combination to Treat Restless Legs Syndrome in Hemodialysis Patients | March 2008 | February 2009 |
| NCT01138124 | Completed | Gabapentin and Risk of Pancreatic Cancer and Renal Cancer (GPRD) | March 2010 | August 2010 | |
| NCT01170091 | Completed | Safety and Effect of Mirapex(Pramipexole) Tablet Among Korean RLS | December 2007 | ||
| NCT01174459 | Completed | Survey on Long-Term Use of BI-Sifrol® Tablets in Patients With Restless Legs Syndrome | August 2010 | August 2013 | |
| NCT01327339 | Completed | REQUIP RLS Post Marketing Surveillance | April 1, 2006 | November 30, 2009 | |
| NCT01332305 | Completed | Phase 2 | Dose-Response and Pharmacokinetics of Gabapentin Enacarbil (GEn [XP13512 / GSK1838262]) in Restless Legs Syndrome | January 2007 | January 2008 |
| NCT01332318 | Completed | Phase 2 | Simulated Driving Study in Restless Legs Syndrome | April 2007 | November 2007 |
| NCT01386944 | Completed | Effect on RLS Symptom Severity After Switching to Neupro® in Patients Who Previously Experienced Augmentation | July 2011 | August 2013 | |
| NCT01455012 | Completed | Phase 4 | Effects of Neupro on Cardiovascular Observations in Patients With Restless Legs Syndrome | September 2011 | June 2012 |
| NCT01476124 | Completed | Phase 1 | Drug Drug Interaction Study With Gabapentin Enacarbil and Morphine | August 2011 | October 2011 |
| NCT01495793 | Completed | Phase 2 | Dose Escalating Study of Rotigotine in Pediatric Subjects With Restless Legs Syndrome | December 2011 | May 2014 |
| NCT01498120 | Completed | Phase 2 | Long-Term Follow-Up Study for Safety, Efficacy and Tolerability of Rotigotine in Adolescents With Restless Legs Syndrome | December 2011 | December 2015 |
| NCT01516372 | Completed | Phase 1 | A Study to Evaluate the Effect of Gabapentin on Cardiac Repolarization in Healthy Volunteers | January 2012 | March 2012 |
| NCT01521663 | Completed | Phase 2 | Safety and Efficacy Study of IPX159 in Restless Legs Syndrome (RLS) | November 2011 | February 2013 |
| NCT01528462 | Completed | Sleep Disorders Managed and Assessed Rapidly in Transient Ischemic Attack (TIA) and In Early Stroke | October 2011 | September 2013 | |
| NCT02670161 | Enrolling by invitation | Phase 4 | Quality Improvement and Practice Based Research in Neurology Using the EMR | May 2016 | December 2026 |
| NCT05529095 | Not yet recruiting | Phase 4 | Sublingual Apomorphine in Refractory Restless Legs Syndrome | September 1, 2022 | March 1, 2023 |
| NCT05350124 | Not yet recruiting | Phase 3 | The Effect of Vitamin C and E Therapy on Restless Leg Syndrome in Patients With End Stage Renal Disease on Haemodialysis | November 2022 | December 2023 |
| NCT04145674 | Recruiting | Phase 2 | A Proof of Concept, Phase 2, Double-blind, Randomized Trial With d-Methadone Product Versus Placebo | October 22, 2022 | July 30, 2025 |
| NCT05581576 | Recruiting | Phase 4 | Pitolisant in Refractory Restless Legs Syndrome | September 20, 2022 | May 1, 2023 |
| NCT05695963 | Recruiting | N/A | Ecological Momentary Assessment in Patients With Restless Legs Syndrome | January 15, 2024 | September 2025 |
| NCT04144790 | Recruiting | Impact of Iron Supplementation Treatment on Brain Iron Concentrations | September 15, 2022 | June 30, 2024 | |
| NCT05003648 | Recruiting | Phase 4 | Treating Leg Symptoms in Women With X-linked Adrenoleukodystrophy | April 1, 2023 | November 1, 2025 |
| NCT06076499 | Recruiting | A Post-Market Study for Long-Term Effectiveness and Safety of the NTX100 for RLS | November 15, 2023 | December 2026 | |
| NCT06156007 | Recruiting | N/A | Effect of Progressive Muscle Relaxation Exercises in Menopausal Women Experiencing RLS. | August 25, 2023 | May 30, 2024 |
| NCT05321355 | Recruiting | Mainz Register of Patients With Sleep Disorders | February 1, 2022 | January 31, 2030 | |
| NCT05044520 | Recruiting | Clinical Features Associated With Restless Legs Syndrome. | September 1, 2021 | September 1, 2027 | |
| NCT01823354 | Recruiting | N/A | Executive Dysfunction in Restless Legs Syndrome: Clinical Correlates and Outcome After Therapeutic Management | November 26, 2012 | May 26, 2026 |
| NCT04759703 | Recruiting | Phase 2/Phase 3 | Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD | January 24, 2022 | June 1, 2025 |
| NCT02929732 | Recruiting | N/A | Analysis of Sympathetic Activity in Willis-Ekbom Disease | March 21, 2017 | October 5, 2025 |
| NCT05985421 | Recruiting | Gut Microbiota and Bacterial Translocation in Restless Legs Syndrome | January 9, 2024 | September 30, 2025 | |
| NCT04462796 | Recruiting | N/A | The Effect of Magnesium Citrate Supplementation in Restless Legs Syndrome (RLS) | July 10, 2020 | December 31, 2023 |
| NCT05908214 | Recruiting | N/A | The Application of Wide Pulse High Frequency Neuromuscular Electrical Stimulation in Disorders Associated With Motoneuron Hyperexcitability | October 1, 2023 | December 31, 2026 |
| NCT05573711 | Recruiting | Restless Legs Syndrome in People With Neuromyelitis Optica Spectrum Disorder | October 1, 2022 | September 1, 2023 | |
| NCT03728933 | Terminated | Phase 3 | A Study of Rotigotine Patch in Adolescent Subjects With Restless Legs Syndrome of Unknown Cause | December 20, 2018 | July 25, 2022 |
| NCT00834327 | Terminated | Phase 2 | Efficacy and Safety Study of Aplindore in Patients With Restless Legs Syndrome | February 2009 | December 2009 |
| NCT04610827 | Terminated | Phase 4 | Oral Iron Frequency for Childhood Restless Leg Syndrome/Periodic Limb Movement Disorder | November 16, 2020 | June 29, 2021 |
| NCT00996944 | Terminated | Phase 2 | Clinical Evaluation of Ropinirole IR (Immediate Release) Tablets in Patients Who Are Diagnosed With Symptomatic Restless Legs Syndrome (RLS) Associated With Chronic Kidney Disease (CKD) Managed With Haemodialysis (Including Haemofiltration and Haemodiafiltration) | November 30, 2009 | June 29, 2010 |
| NCT01192503 | Terminated | Phase 2/Phase 3 | Safety and Efficacy of Rasagiline in Restless Legs Syndrome | September 2010 | August 2012 |
| NCT03345953 | Terminated | Phase 2 | Clinical Trial Assessing the Efficacy and Safety of BP1.4979 in Restless Legs Syndrome | February 6, 2018 | April 29, 2020 |
| NCT03708237 | Terminated | Phase 2 | Effectiveness of Ropinirole and Gabapentin for the Treatment of RLS in Patients on Maintenance HD | February 19, 2019 | December 11, 2019 |
| NCT03817554 | Terminated | Phase 4 | Pramipexole for Restless Leg Syndrome in Peritoneal Dialysis Patients | July 1, 2019 | August 31, 2020 |
| NCT03852771 | Terminated | N/A | REST Study (CompRESsion Therapy for RLS) | March 12, 2019 | January 31, 2020 |
| NCT03992196 | Terminated | Phase 3 | A Follow-up Study of Rotigotine Patch in Adolescent Subjects With Restless Legs Syndrome | December 3, 2019 | September 1, 2022 |
| NCT03755310 | Unknown status | Phase 2 | Treatment of Restless Legs Syndrome With the Hypocretin Antagonist Suvorexant | February 2019 | March 2020 |
| NCT02419014 | Unknown status | N/A | Cranial Electrotherapy for Military Beneficiaries With Restless Legs Syndrome | February 2014 | February 2017 |
| NCT03218969 | Unknown status | Phase 1/Phase 2 | Treatment of Restless Leg Syndrome (RLS) Augmentation With Ecopipam, a D1 Specific Antagonist | September 18, 2017 | October 15, 2018 |
| NCT02264600 | Unknown status | Apelin in Willis Ekbom Disease | November 2014 | April 2015 | |
| NCT00656110 | Unknown status | N/A | Neuroma Injections to Treat Restless Legs Syndrome - RCT | April 2008 | December 2009 |
| NCT04786314 | Unknown status | N/A | The Effect of Hot and Cold Water Application on Pregnant Women With Restless Leg Syndrome | September 30, 2020 | September 30, 2022 |
| NCT04303143 | Unknown status | Hypnosis and Direct Autonomic Experience Influence on Chronic Symptoms | March 2021 | July 2021 | |
| NCT02256215 | Unknown status | Phase 2/Phase 3 | Vitamin D in the Treatment of Primary Restless Legs Syndrome | December 2015 | |
| NCT01937169 | Unknown status | N/A | Targeting Dopamine Therapy in RLS | January 2014 | |
| NCT00258492 | Unknown status | Phase 1/Phase 2 | Restless Legs Syndrome Exercise Intervention | December 2005 | January 2007 |
| NCT02424695 | Unknown status | Phase 4 | Effects of Gabapentin Enacarbil on Arousals, Heart Rate, Blood Pressure and PLMs in Restless Legs Syndrome | June 2015 | July 2016 |
| NCT02138357 | Withdrawn | Phase 4 | Butrans for Treatment of Restless Legs Syndrome | April 2014 | December 2016 |
| NCT00584246 | Withdrawn | Phase 4 | Pregabalin (Lyrica) for the Treatment of Restless Legs Syndrome | November 2007 | May 2008 |
| NCT03849001 | Withdrawn | N/A | Impact of Acute Leg Cycling at Various Intensities on RLS Severity in Persons With MS | September 1, 2019 | September 1, 2019 |
| NCT01061372 | Withdrawn | Phase 3 | 12-Week Efficacy And Safety Of Pregabalin In Treating Restless Legs Syndrome (RLS) Subjects | May 2010 | August 2011 |
| NCT02484768 | Withdrawn | Phase 2 | IV Iron Treatment of Restless Legs Syndrome | January 2015 | February 2015 |
- Disase is a (Disease Ontology)
- DOID:331
- Cross Reference ID (Disease Ontology)
- EFO:0004270
- Cross Reference ID (Disease Ontology)
- GARD:11926
- Cross Reference ID (Disease Ontology)
- ICD10CM:G25.81
- Cross Reference ID (Disease Ontology)
- ICD9CM:333.94
- Cross Reference ID (Disease Ontology)
- MESH:D012148
- Cross Reference ID (Disease Ontology)
- MIM:PS102300
- Cross Reference ID (Disease Ontology)
- NCI:C84501
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:32914008
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0035258
- Exact Synonym (Disease Ontology)
- WED
- Exact Synonym (Disease Ontology)
- Willis-Ekbom disease
- Exact Synonym (Disease Ontology)
- Wittmaack-Ekbom syndrome
- OMIM Phenotype Series Number (OMIM)
- PS102300
- MeSH unique ID (MeSH (Medical Subject Headings))
- D012148