chr2:178977164:> Detail (hg19)

Information

Genome

Assembly Position
hg19 chr2:178,977,164-178,994,383
hg38 chr2:178,112,437-178,129,656 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
<0.001 Cardiomyopathy, Dilated NA BeFree Detail
<0.001 Cardiovascular Diseases NA BeFree Detail
<0.001 Cataplexy NA BeFree Detail
0.004 celiac disease NA BeFree Detail
<0.001 CNS disorder NA BeFree Detail
0.005 Malignant tumor of cervix Human leukocyte antigen-DRB1*1501 and DQB1*0602 alleles are cervical cancer prot... BeFree 25337265 Detail
0.005 Malignant tumor of cervix Our results confirmed the assessment of DRB1*13 as a protective marker in HPV in... BeFree 25673541 Detail
0.005 Malignant tumor of cervix Human leukocyte antigen class II DRB1*1302 allele protects against cervical canc... BeFree 26235935 Detail
<0.001 Cervix Diseases NA BeFree Detail
<0.001 Chlamydia Infections NA BeFree Detail
0.003 Primary biliary cirrhosis NA BeFree Detail
0.002 Cholangitis, Sclerosing NA BeFree Detail
0.002 colitis NA BeFree Detail
0.005 ulcerative colitis NA BeFree Detail
<0.001 Colonic Diseases NA BeFree Detail
<0.001 Coronary heart disease NA BeFree Detail
0.001 Crohn Disease NA BeFree Detail
<0.001 Dengue Fever NA BeFree Detail
<0.001 dermatomyositis NA BeFree Detail
<0.001 scleroderma NA BeFree Detail
0.008 Diabetes NA BeFree Detail
0.008 diabetes mellitus NA BeFree Detail
0.045 Diabetes Mellitus, Insulin-Dependent DRB1 and DQB1 allele frequencies were similar for both A(-) KPD and T2D patients... BeFree 25511714 Detail
0.045 Diabetes Mellitus, Insulin-Dependent The frequency of DRB1*04:05-DQB1*04:01, a susceptible haplotype for type 1 diabe... BeFree 25734250 Detail
0.045 Diabetes Mellitus, Insulin-Dependent Because of the strong association of T1D with DRB1*03:01 and DRB1*04:01, we stra... BeFree 26539552 Detail
0.002 Diabetes Mellitus, Non-Insulin-Dependent Overall, we did not find any evidence of susceptibility to ketosis associated wi... BeFree 25511714 Detail
<0.001 duodenal ulcer NA BeFree Detail
<0.001 Encephalomyelitis, Acute Disseminated NA BeFree Detail
0.001 Experimental Autoimmune Encephalomyelitis NA BeFree Detail
<0.001 Enterocolitis NA BeFree Detail
<0.001 Toxic Epidermal Necrolysis NA BeFree Detail
<0.001 Disorder of eye NA BeFree Detail
<0.001 Fatigue NA BeFree Detail
<0.001 gastritis NA BeFree Detail
<0.001 Gastritis, Atrophic NA BeFree Detail
<0.001 Gingival Diseases HLA types -B15 (PBonf = 0.002), -B51 (PBonf = 0.02) and -DRB1*12 (PBonf = 0.02) ... BeFree 25072155 Detail
<0.001 Glioma NA BeFree Detail
<0.001 IgA glomerulonephritis NA BeFree Detail
0.002 Graft-vs-Host Disease NA BeFree Detail
0.008 Graves Disease NA BeFree Detail
<0.001 Sensorineural Hearing Loss (disorder) NA BeFree Detail
<0.001 congestive heart failure NA BeFree Detail
<0.001 Hemophilia A NA BeFree Detail
<0.001 Severe Dengue NA BeFree Detail
<0.001 Hemorrhagic Fever with Renal Syndrome Meanwhile, the DRB1*1101-1105 allele was more frequently observed in the severe ... BeFree 25169964 Detail
0.002 hepatitis NA BeFree Detail
0.002 hepatitis A NA BeFree Detail
0.005 hepatitis B Characterization and genotyping of the DRB1 gene of the major histocompatibility... BeFree 25458311 Detail
0.005 hepatitis B The results revealed that A*02-DRB1*12 and A*02-B*15-DRB1*09 carriers were susce... BeFree 25592155 Detail
<0.001 Hepatitis, Chronic NA BeFree Detail
0.002 hepatitis C NA BeFree Detail
<0.001 Herpes zoster disease NA BeFree Detail
0.005 HIV Infections These results provide strong evidence that HLA DRB1*15, DRB1*10, B-27/57, B-14, ... BeFree 24797997 Detail
<0.001 hypercalcemia NA BeFree Detail
<0.001 hyperglycemia NA BeFree Detail
<0.001 Ileal Diseases NA BeFree Detail
<0.001 Immune System Diseases NA BeFree Detail
<0.001 infectious mononucleosis NA BeFree Detail
<0.001 Inflammatory Bowel Diseases NA BeFree Detail
<0.001 influenza NA BeFree Detail
<0.001 iridocyclitis NA BeFree Detail
<0.001 iritis NA BeFree Detail
<0.001 irritable bowel syndrome NA BeFree Detail
<0.001 Ketosis Factors other than DRB1 and DQB1 genotype could explain the propensity to ketosi... BeFree 25511714 Detail
<0.001 Kidney Diseases When analyzing the DRB1*03:01-positive retinopathy families, in addition to the ... BeFree 26539552 Detail
<0.001 Kidney Failure, Acute NA BeFree Detail
0.001 Kidney Failure, Chronic The haplotypes positively associated with ESRD were: HLA-A*01-DRB1*13 and HLA-A*... BeFree 25380295 Detail
0.002 leprosy NA BeFree Detail
<0.001 borderline leprosy NA BeFree Detail
<0.001 Leprosy, Lepromatous NA BeFree Detail
<0.001 leukemia NA BeFree Detail
<0.001 chronic lymphocytic leukemia NA BeFree Detail
0.001 Acute lymphocytic leukemia NA BeFree Detail
<0.001 Leukemia, Lymphocytic, Acute, L1 NA BeFree Detail
<0.001 Leukemia, Myelocytic, Acute NA BeFree Detail
0.001 Myeloid Leukemia, Chronic NA BeFree Detail
<0.001 Leukemia, Plasma Cell NA BeFree Detail
<0.001 Adult T-Cell Lymphoma/Leukemia NA BeFree Detail
<0.001 Lichen planus follicularis To determine whether the HLA system is associated with LPP, 40 consecutive Jewis... BeFree 24806356 Detail
0.002 liver cirrhosis In a multivariate logistic regression analysis, DRB1*07 remained a significant n... BeFree 25009391 Detail
0.002 Liver diseases NA BeFree Detail
0.010 Lupus Erythematosus, Systemic Risk alleles for SLE and PM/DM were B*08 and DRB1*03:01. BeFree 25187641 Detail
<0.001 lupus nephritis NA BeFree Detail
<0.001 Lyme disease NA BeFree Detail
<0.001 Lymphoma, Follicular NA BeFree Detail
0.002 malaria NA BeFree Detail
<0.001 Malaria, Vivax NA BeFree Detail
<0.001 Malignant neoplasm of stomach NA BeFree Detail
<0.001 paroxysmal nocturnal hemoglobinuria NA BeFree Detail
<0.001 measles NA BeFree Detail
0.002 melanoma NA BeFree Detail
<0.001 meningioma NA BeFree Detail
<0.001 mitral valve insufficiency NA BeFree Detail
0.002 mitral valve stenosis NA BeFree Detail
<0.001 mixed connective tissue disease Novel HLA alleles associated with MCTD and disease subsets were identified and D... BeFree 25187641 Detail
<0.001 Mouth Diseases Associations of HLA-A, -B and -DRB1 types with oral diseases in Swiss adults. BeFree 25072155 Detail
<0.001 Mucocutaneous Lymph Node Syndrome To maximize the informativeness of single nucleotide polymorphism (SNP) genotype... BeFree 25809546 Detail
0.001 multiple myeloma NA BeFree Detail
<0.001 myopathy NA BeFree Detail
0.003 myasthenia gravis High frequency of DQB1*05 and absolute absence of DRB1*13 in muscle-specific tyr... BeFree 25070808 Detail
<0.001 Mycobacterium avium-intracellulare Infection NA BeFree Detail
<0.001 mycosis fungoides NA BeFree Detail
0.001 myositis NA BeFree Detail
0.004 narcolepsy NA BeFree Detail
<0.001 nephritis NA BeFree Detail
<0.001 neuromyelitis optica NA BeFree Detail
<0.001 Ophthalmia, Sympathetic NA BeFree Detail
<0.001 Opportunistic Infections NA BeFree Detail
<0.001 optic neuritis NA BeFree Detail
<0.001 ovarian carcinoma NA BeFree Detail
<0.001 pancreatitis NA BeFree Detail
<0.001 pancytopenia NA BeFree Detail
<0.001 tropical spastic paraparesis NA BeFree Detail
<0.001 Paresis NA BeFree Detail
0.002 pemphigus NA BeFree Detail
0.006 pemphigus vulgaris The DRB1*04:02 and DQB1*03:02 alleles were associated with severe PV (P = 0.001)... BeFree 24602055 Detail
0.006 pemphigus vulgaris We noticed an increased frequency of HLA-DRB1*04 and DRB1*14 alleles in patients... BeFree 24697292 Detail
<0.001 Periodontal Diseases HLA types -B15 (PBonf = 0.002), -B51 (PBonf = 0.02) and -DRB1*12 (PBonf = 0.02) ... BeFree 25072155 Detail
<0.001 Periodontitis, Juvenile NA BeFree Detail
<0.001 Petechiae NA BeFree Detail
<0.001 Polymorphous light eruption NA BeFree Detail
<0.001 pneumonia NA BeFree Detail
<0.001 polycystic ovary syndrome NA BeFree Detail
0.001 polymyalgia rheumatica NA BeFree Detail
<0.001 Postherpetic neuralgia NA BeFree Detail
<0.001 Preleukemia NA BeFree Detail
<0.001 proctitis NA BeFree Detail
0.003 psoriasis NA BeFree Detail
<0.001 pulmonary emphysema NA BeFree Detail
<0.001 pulmonary fibrosis Analyses of MCTD subsets identified B*18 [OR 3.32 (95% CI 1.38, 8.01)] and DRB1*... BeFree 25187641 Detail
0.001 kidney failure Human leukocyte antigen (HLA) gene typing showed DRB1*1501, an allele strongly a... BeFree 26200622 Detail
<0.001 Retinal Diseases NA BeFree Detail
<0.001 retinoblastoma NA BeFree Detail
<0.001 rheumatic fever NA BeFree Detail
0.001 rheumatic heart disease NA BeFree Detail
<0.001 Rheumatoid Nodule NA BeFree Detail
0.007 sarcoidosis Further investigation of DRB1*03 alleles may uncover immunologic factors that fa... BeFree 25506722 Detail
<0.001 Sarcoidosis, Pulmonary NA BeFree Detail
0.005 schizophrenia NA BeFree,GAD Detail
0.005 systemic scleroderma DRB1*15 was associated with ATA positive Chinese SSc that is consistent with Bla... BeFree 25184637 Detail
<0.001 Soft Tissue Neoplasms NA BeFree Detail
0.002 ankylosing spondylitis Polymorphisms of HLA-A, -B, -Cw and DRB1 antigens in Moroccan patients with anky... BeFree 25626601 Detail
<0.001 Stevens-Johnson syndrome NA BeFree Detail
<0.001 gastric ulcer NA BeFree Detail
<0.001 Cerebrovascular accident NA BeFree Detail
0.002 Takayasu Arteritis HLA-DQA1, DQB1 and DRB1 alleles associated with Takayasu arteritis in the Chines... BeFree 25636572 Detail
0.002 Giant Cell Arteritis NA BeFree Detail
<0.001 thromboangiitis obliterans NA BeFree Detail
0.001 thymoma NA BeFree Detail
<0.001 Thymus Hyperplasia NA BeFree Detail
<0.001 thyroiditis NA BeFree Detail
<0.001 trachoma NA BeFree Detail
0.001 Chagas disease NA BeFree Detail
0.002 tuberculosis NA BeFree Detail
0.003 Tuberculosis, Pulmonary In the comparison of TAP2 gene with the DRB1*08:03, which is associated with TAP... BeFree 25846714 Detail
<0.001 typhoid fever NA BeFree Detail
0.001 uveitis NA BeFree Detail
0.001 Uveomeningoencephalitic Syndrome NA BeFree Detail
0.001 vasculitis NA BeFree Detail
<0.001 Viremia NA BeFree Detail
0.001 Virus Diseases NA BeFree Detail
0.001 vitiligo NA BeFree Detail
<0.001 spina bifida NA BeFree Detail
<0.001 Bronchial Hyperreactivity NA BeFree Detail
<0.001 eosinophilia-myalgia syndrome NA BeFree Detail
<0.001 antiphospholipid syndrome NA BeFree Detail
<0.001 Toxoplasmosis, Cerebral NA BeFree Detail
0.001 Polyendocrinopathies, Autoimmune NA BeFree Detail
<0.001 Arthritis, Reactive NA BeFree Detail
<0.001 Liver failure The frequency of the DRB1*08:03-DQB1*06:01 haplotype was significantly higher in... BeFree 24956105 Detail
<0.001 polymyositis NA BeFree Detail
<0.001 acute leukemia NA BeFree Detail
<0.001 Sicca Syndrome NA BeFree Detail
0.045 Diabetes Mellitus, Insulin-Dependent Human RAGE GLY82SER dimorphism and HLA class II DRB1-DQA1-DQB1 haplotypes in typ... BeFree 10553500 Detail
<0.001 congenital heart block NA BeFree Detail
<0.001 Epstein-Barr Virus Infections NA BeFree Detail
<0.001 Migraine Disorders NA BeFree Detail
<0.001 Myocardial Ischemia NA BeFree Detail
<0.001 Muscle Weakness NA BeFree Detail
<0.001 Idiopathic pulmonary hypertension NA BeFree Detail
0.001 allergic asthma NA BeFree Detail
<0.001 intrinsic asthma NA BeFree Detail
<0.001 Pauciarticular juvenile rheumatoid arthritis NA BeFree Detail
<0.001 Polyarthritis NA BeFree Detail
0.001 Immunoglobulin A deficiency (disorder) As expected, the risk-conveying HLA alleles A*01, B*08 and DRB1*01 were overrepr... BeFree 25569265 Detail
<0.001 hidradenitis suppurativa NA BeFree Detail
<0.001 Aortic Aneurysm, Abdominal NA BeFree Detail
0.002 Autoimmune thyroid disease NA BeFree Detail
<0.001 Diabetes, Autoimmune NA BeFree Detail
<0.001 Lung Diseases, Interstitial NA BeFree Detail
<0.001 focal epithelial hyperplasia NA BeFree Detail
<0.001 Cervical Intraepithelial Neoplasia NA BeFree Detail
<0.001 Chronic berylliosis NA BeFree Detail
<0.001 Adult type dermatomyositis NA BeFree Detail
<0.001 Lesion of brain NA BeFree Detail
<0.001 pancreatic carcinoma NA BeFree Detail
<0.001 Inclusion Body Myositis (disorder) NA BeFree Detail
<0.001 Rheumatoid Vasculitis NA BeFree Detail
0.007 Hepatitis, Autoimmune The DRB1*04:05-DQB1*04:01 haplotype was significantly associated with AIH suscep... BeFree 24956105 Detail
0.007 Hepatitis, Autoimmune Two types of autoimmune hepatitis are justified by serological markers, but they... BeFree 25999246 Detail
<0.001 Malignant neoplasm of lung NA BeFree Detail
<0.001 Lyme Arthritis NA BeFree Detail
<0.001 age related macular degeneration Comprehensive human leukocyte antigens (HLA) class II typing at four loci (DRB1,... BeFree 25665771 Detail
<0.001 nephropathia epidemica NA BeFree Detail
<0.001 Vasculitis of the skin NA BeFree Detail
0.001 pemphigus foliaceus NA BeFree Detail
<0.001 Pemphigus and fogo selvagem NA BeFree Detail
0.001 Psoriasis vulgaris NA BeFree Detail
<0.001 Alopecia totalis NA BeFree Detail
<0.001 alopecia universalis NA BeFree Detail
<0.001 Dermatomyositis, Childhood Type NA BeFree Detail
<0.001 Childhood asthma NA BeFree Detail
<0.001 Asthma, Occupational NA BeFree Detail
<0.001 Sequoiosis NA BeFree Detail
<0.001 Acute respiratory failure NA BeFree Detail
<0.001 Rheumatic disease of heart valve NA BeFree Detail
<0.001 Rapidly progressive periodontitis NA BeFree Detail
<0.001 Chronic Periodontitis NA BeFree Detail
<0.001 Acute viral hepatitis NA BeFree Detail
<0.001 Metastatic Renal Cell Cancer NA BeFree Detail
<0.001 gastric adenocarcinoma NA BeFree Detail
<0.001 Solid tumour NA BeFree Detail
0.006 cervix carcinoma Human leukocyte antigen-DRB1*1501 and DQB1*0602 alleles are cervical cancer prot... BeFree 25337265 Detail
0.006 cervix carcinoma Our results confirmed the assessment of DRB1*13 as a protective marker in HPV in... BeFree 25673541 Detail
0.006 cervix carcinoma Human leukocyte antigen class II DRB1*1302 allele protects against cervical canc... BeFree 26235935 Detail
0.002 Superficial ulcer NA BeFree Detail
<0.001 Hypothyroidism, Autoimmune NA BeFree Detail
<0.001 Idiopathic Hypoparathyroidism NA BeFree Detail
<0.001 Microscopic Polyangiitis NA BeFree Detail
<0.001 Streptococcal toxic shock syndrome NA BeFree Detail
<0.001 Human papilloma virus infection NA BeFree Detail
<0.001 Chronic Chagas' disease NA BeFree Detail
<0.001 Malignant neoplasm of pancreas NA BeFree Detail
<0.001 dengue shock syndrome NA BeFree Detail
<0.001 Malignant neoplasm of prostate NA BeFree Detail
<0.001 Hematologic Neoplasms NA BeFree Detail
<0.001 Early onset periodontitis NA BeFree Detail
<0.001 Steroid-sensitive nephrotic syndrome NA BeFree Detail
0.001 Anti-Glomerular Basement Membrane Disease Human leukocyte antigen (HLA) gene typing showed DRB1*1501, an allele strongly a... BeFree 26200622 Detail
<0.001 Actinic prurigo NA BeFree Detail
<0.001 Seropositive rheumatoid arthritis NA BeFree Detail
<0.001 Undifferentiated inflammatory oligoarthritis NA BeFree Detail
<0.001 Primary antiphospholipid syndrome NA BeFree Detail
<0.001 Overlap syndrome NA BeFree Detail
<0.001 Halo nevus NA BeFree Detail
<0.001 pricking of skin NA BeFree Detail
<0.001 Chronic active hepatitis NA BeFree Detail
<0.001 Metabolic syndrome X NA BeFree Detail
0.002 Hepatitis B, Chronic Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepati... BeFree 25009391 Detail
0.002 Hepatitis C, Chronic NA BeFree Detail
<0.001 Mixed cryoglobulinemia NA BeFree Detail
<0.001 Allergy to peanuts NA BeFree Detail
0.003 primary sclerosing cholangitis We incorporated data from HLA typing (HLA-A, -B, -C, -DRB3, -DRB1, -DQB1) and si... BeFree 25521205 Detail
<0.001 Nut Hypersensitivity NA BeFree Detail
<0.001 Carcinogenesis Human leukocyte antigen class II DRB1*1302 allele protects against cervical canc... BeFree 26235935 Detail
<0.001 prostate carcinoma NA BeFree Detail
<0.001 Hashimoto Disease NA BeFree Detail
<0.001 breast carcinoma NA BeFree Detail
<0.001 Carcinoma of lung NA BeFree Detail
<0.001 Hemophilia, NOS NA BeFree Detail
<0.001 Allergy to fruit NA BeFree Detail
0.001 stomach carcinoma NA BeFree Detail
<0.001 Acute anterior uveitis NA BeFree Detail
<0.001 Microalbuminuria NA BeFree Detail
<0.001 cervical cancer squamous cell NA BeFree Detail
<0.001 Chronic lung disease NA BeFree Detail
<0.001 lupus cutaneous NA BeFree Detail
0.001 Idiopathic Inflammatory Myopathies NA BeFree Detail
0.003 Narcolepsy-Cataplexy Syndrome NA BeFree,GAD Detail
<0.001 Multiple Sclerosis, Primary Progressive NA BeFree Detail
<0.001 Multiple Sclerosis, Relapsing-Remitting NA BeFree Detail
<0.001 psychological distress NA BeFree Detail
0.001 Helicobacter pylori infection DRB1 1501 and C. pneumoniae infection confer CSF IgG abnormality, while DRB1 040... BeFree 24736746 Detail
0.002 Insulin autoimmune syndrome NA BeFree Detail
<0.001 Retinoblastoma unilateral NA BeFree Detail
<0.001 Philadelphia chromosome positive NA BeFree Detail
0.002 Acute GVH disease Thus, the number of HLA-A, -B, -C, -DPB1, and DRB1_DQB1 mismatches showed a clea... BeFree 25519752 Detail
<0.001 dmac NA BeFree Detail
<0.001 Pancolitis NA BeFree Detail
<0.001 Cardiomyopathies NA BeFree Detail
0.001 Diffuse panbronchiolitis NA BeFree Detail
<0.001 Alloimmunisation NA BeFree Detail
<0.001 Spondylarthritis NA BeFree Detail
<0.001 Spondylarthropathies NA BeFree Detail
0.002 Arthritis, Collagen-Induced NA BeFree Detail
<0.001 paraneoplastic pemphigus NA BeFree Detail
<0.001 Malignant neoplasm of ovary NA BeFree Detail
<0.001 severe acute respiratory syndrome NA BeFree Detail
<0.001 diffuse scleroderma NA BeFree Detail
0.001 Persistent infection NA BeFree Detail
<0.001 Ocular Cicatricial Pemphigoid NA BeFree Detail
<0.001 Post-streptococcal reactive arthritis NA BeFree Detail
<0.001 Familial psoriasis NA BeFree Detail
<0.001 Localized vitiligo NA BeFree Detail
<0.001 diffuse infiltrative lymphocytosis syndrome NA BeFree Detail
<0.001 High Grade Cervical Intraepithelial Neoplasia NA BeFree Detail
<0.001 Infiltrating Cervical Carcinoma NA BeFree Detail
<0.001 Nodular Lymphocyte Predominant Hodgkin Lymphoma NA BeFree Detail
<0.001 Testicular Germ Cell Tumor NA BeFree Detail
<0.001 Cardiomyopathy, Familial Idiopathic NA BeFree Detail
<0.001 Sarcoid arthritis NA BeFree Detail
<0.001 Chronic iridocyclitis NA BeFree Detail
0.001 Cirrhosis In a multivariate logistic regression analysis, DRB1*07 remained a significant n... BeFree 25009391 Detail
<0.001 Inflammatory polyarthritis NA BeFree Detail
<0.001 Nephrotic Syndrome, Minimal Change NA BeFree Detail
<0.001 Meningioma, benign, no ICD-O subtype NA BeFree Detail
<0.001 Idiopathic Pulmonary Fibrosis NA BeFree Detail
0.001 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) NA BeFree Detail
<0.001 birdshot chorioretinopathy Genes encoding for human leukocyte antigens (HLAs) have been shown to be associa... BeFree 26310161 Detail
<0.001 Severe Aplastic Anemia NA BeFree Detail
<0.001 temporal arteritis NA BeFree Detail
<0.001 Parvovirus B19 (disease) NA BeFree Detail
<0.001 Acute lyme disease NA BeFree Detail
<0.001 Precursor Cell Lymphoblastic Leukemia Lymphoma NA BeFree Detail
0.001 liver carcinoma Conversely, the DRB1*15:01-DQB1*06:02 haplotype was associated with protection f... BeFree 24956105 Detail
<0.001 autoimmune pancreatitis NA BeFree Detail
<0.001 Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Human leukocyte antigen (HLA) gene typing showed DRB1*1501, an allele strongly a... BeFree 26200622 Detail
<0.001 Immunoglobulin a deficiency 1 NA BeFree Detail
<0.001 Sclerosing lymphocytic lobulitis NA BeFree Detail
<0.001 Juvenile dermatomyositis NA BeFree Detail
<0.001 Nasopharyngeal carcinoma NA BeFree Detail
<0.001 Idiopathic pulmonary arterial hypertension NA BeFree Detail
<0.001 Ulcerative Colitis-Associated Colorectal Adenocarcinoma In contrast, the presence of the DRB1*11:01 allele was negatively associated wit... BeFree 25346274 Detail
<0.001 myelodysplastic syndrome NA BeFree Detail
<0.001 American cutaneous leishmaniasis NA BeFree Detail
0.003 Juvenile arthritis NA BeFree Detail
0.002 Allergic disposition NA BeFree Detail
<0.001 Allergic sensitization NA BeFree Detail
<0.001 Opticospinal Multiple Sclerosis NA BeFree Detail
0.005 juvenile rheumatoid arthritis NA BeFree Detail
<0.001 agranulocytosis NA BeFree Detail
<0.001 Alzheimer's disease The authors believe this to be the first research linking the haplotypes DRB1*15... BeFree 25651370 Detail
0.010 Lupus Erythematosus, Systemic Sequential removal of SLE-associated DRB1 haplotypes revealed independent effect... BeFree 19851445 Detail
0.002 aplastic anemia NA BeFree Detail
0.004 arthritis NA BeFree Detail
<0.001 Arthritis, Psoriatic NA BeFree Detail
0.049 rheumatoid arthritis HLA-DRB1 and HLA-DQB1 allele associations in an Albanian patient population with... BeFree 24381092 Detail
0.049 rheumatoid arthritis Several DRB 1 alleles are associated with susceptibility to and severity of rheu... BeFree 24887053 Detail
0.049 rheumatoid arthritis Thus, this study identified a negative association of DRB1*13:02 with Japanese R... BeFree 24911054 Detail
0.049 rheumatoid arthritis In the presence of SE, the DRB1(∗)04:05 and HLA-DRB4(∗)01 were associated with R... BeFree 25636569 Detail
0.049 rheumatoid arthritis Brief Report: Main Contribution of DRB1*04:05 Among the Shared Epitope Alleles a... BeFree 25777156 Detail
<0.001 Aspergillosis, Allergic Bronchopulmonary NA BeFree Detail
0.003 asthma NA BeFree Detail
<0.001 Ataxia NA BeFree Detail
<0.001 autistic disorder DNA typing of HLA-A, -C, -B, AND -DRB1 in the children with autism in the Republ... BeFree 25666956 Detail
0.004 Autoimmune Diseases NA BeFree Detail
<0.001 azoospermia NA BeFree Detail
<0.001 Balkan nephropathy NA BeFree Detail
<0.001 Blast Phase NA BeFree Detail
<0.001 Malignant neoplasm of breast NA BeFree Detail
<0.001 calcinosis NA BeFree Detail
Annotation

Annotations

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Human leukocyte antigen-DRB1*1501 and DQB1*0602 alleles are cervical cancer protective factors among... DisGeNET Detail
Our results confirmed the assessment of DRB1*13 as a protective marker in HPV infection outcome. our... DisGeNET Detail
Human leukocyte antigen class II DRB1*1302 allele protects against cervical cancer: At which step of... DisGeNET Detail
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DRB1 and DQB1 allele frequencies were similar for both A(-) KPD and T2D patients; they did not confe... DisGeNET Detail
The frequency of DRB1*04:05-DQB1*04:01, a susceptible haplotype for type 1 diabetes, was significant... DisGeNET Detail
Because of the strong association of T1D with DRB1*03:01 and DRB1*04:01, we stratified our analyses ... DisGeNET Detail
Overall, we did not find any evidence of susceptibility to ketosis associated with DRB1 and DQB1 gen... DisGeNET Detail
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HLA types -B15 (PBonf = 0.002), -B51 (PBonf = 0.02) and -DRB1*12 (PBonf = 0.02) were associated with... DisGeNET Detail
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Meanwhile, the DRB1*1101-1105 allele was more frequently observed in the severe course of HTNV-infec... DisGeNET Detail
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Characterization and genotyping of the DRB1 gene of the major histocompatibility complex (MHC) in th... DisGeNET Detail
The results revealed that A*02-DRB1*12 and A*02-B*15-DRB1*09 carriers were susceptible to HBV infect... DisGeNET Detail
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These results provide strong evidence that HLA DRB1*15, DRB1*10, B-27/57, B-14, Cw-8, B-57 are assoc... DisGeNET Detail
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Factors other than DRB1 and DQB1 genotype could explain the propensity to ketosis in A(-) KPD. DisGeNET Detail
When analyzing the DRB1*03:01-positive retinopathy families, in addition to the novel telomeric locu... DisGeNET Detail
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The haplotypes positively associated with ESRD were: HLA-A*01-DRB1*13 and HLA-A*30-DRBI*03. DisGeNET Detail
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To determine whether the HLA system is associated with LPP, 40 consecutive Jewish Israeli patients w... DisGeNET Detail
In a multivariate logistic regression analysis, DRB1*07 remained a significant negative predictor of... DisGeNET Detail
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Risk alleles for SLE and PM/DM were B*08 and DRB1*03:01. DisGeNET Detail
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Novel HLA alleles associated with MCTD and disease subsets were identified and DRB1*04:01 was confir... DisGeNET Detail
Associations of HLA-A, -B and -DRB1 types with oral diseases in Swiss adults. DisGeNET Detail
To maximize the informativeness of single nucleotide polymorphism (SNP) genotypes in the major histo... DisGeNET Detail
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High frequency of DQB1*05 and absolute absence of DRB1*13 in muscle-specific tyrosine kinase positiv... DisGeNET Detail
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The DRB1*04:02 and DQB1*03:02 alleles were associated with severe PV (P = 0.001); DRB1*04:02 was ass... DisGeNET Detail
We noticed an increased frequency of HLA-DRB1*04 and DRB1*14 alleles in patients with PV compared wi... DisGeNET Detail
HLA types -B15 (PBonf = 0.002), -B51 (PBonf = 0.02) and -DRB1*12 (PBonf = 0.02) were associated with... DisGeNET Detail
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Analyses of MCTD subsets identified B*18 [OR 3.32 (95% CI 1.38, 8.01)] and DRB1*03:01 [OR 1.83 (95% ... DisGeNET Detail
Human leukocyte antigen (HLA) gene typing showed DRB1*1501, an allele strongly associated with anti-... DisGeNET Detail
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Further investigation of DRB1*03 alleles may uncover immunologic factors that favor sarcoidosis prot... DisGeNET Detail
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DRB1*15 was associated with ATA positive Chinese SSc that is consistent with Black South African and... DisGeNET Detail
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Polymorphisms of HLA-A, -B, -Cw and DRB1 antigens in Moroccan patients with ankylosing spondylitis a... DisGeNET Detail
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HLA-DQA1, DQB1 and DRB1 alleles associated with Takayasu arteritis in the Chinese Han population. DisGeNET Detail
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In the comparison of TAP2 gene with the DRB1*08:03, which is associated with TAP2*Bky2 and PTB in Ko... DisGeNET Detail
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The frequency of the DRB1*08:03-DQB1*06:01 haplotype was significantly higher in patients who develo... DisGeNET Detail
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Human RAGE GLY82SER dimorphism and HLA class II DRB1-DQA1-DQB1 haplotypes in type 1 diabetes. DisGeNET Detail
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As expected, the risk-conveying HLA alleles A*01, B*08 and DRB1*01 were overrepresented among the Ig... DisGeNET Detail
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The DRB1*04:05-DQB1*04:01 haplotype was significantly associated with AIH susceptibility (30% vs. 11... DisGeNET Detail
Two types of autoimmune hepatitis are justified by serological markers, but they also have distincti... DisGeNET Detail
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Comprehensive human leukocyte antigens (HLA) class II typing at four loci (DRB1, DQA1, DQB1, and DPB... DisGeNET Detail
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Human leukocyte antigen-DRB1*1501 and DQB1*0602 alleles are cervical cancer protective factors among... DisGeNET Detail
Our results confirmed the assessment of DRB1*13 as a protective marker in HPV infection outcome. our... DisGeNET Detail
Human leukocyte antigen class II DRB1*1302 allele protects against cervical cancer: At which step of... DisGeNET Detail
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Human leukocyte antigen (HLA) gene typing showed DRB1*1501, an allele strongly associated with anti-... DisGeNET Detail
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Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B. DisGeNET Detail
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We incorporated data from HLA typing (HLA-A, -B, -C, -DRB3, -DRB1, -DQB1) and single nucleotide poly... DisGeNET Detail
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Human leukocyte antigen class II DRB1*1302 allele protects against cervical cancer: At which step of... DisGeNET Detail
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DRB1 1501 and C. pneumoniae infection confer CSF IgG abnormality, while DRB1 0405 and H. pylori infe... DisGeNET Detail
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Thus, the number of HLA-A, -B, -C, -DPB1, and DRB1_DQB1 mismatches showed a clear-cut risk differenc... DisGeNET Detail
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In a multivariate logistic regression analysis, DRB1*07 remained a significant negative predictor of... DisGeNET Detail
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Genes encoding for human leukocyte antigens (HLAs) have been shown to be associated with certain uve... DisGeNET Detail
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Conversely, the DRB1*15:01-DQB1*06:02 haplotype was associated with protection from both disease ons... DisGeNET Detail
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Human leukocyte antigen (HLA) gene typing showed DRB1*1501, an allele strongly associated with anti-... DisGeNET Detail
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In contrast, the presence of the DRB1*11:01 allele was negatively associated with CRC tumor as evide... DisGeNET Detail
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The authors believe this to be the first research linking the haplotypes DRB1*1501/DQB1*0602 and DRB... DisGeNET Detail
Sequential removal of SLE-associated DRB1 haplotypes revealed independent effects due to variation w... DisGeNET Detail
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HLA-DRB1 and HLA-DQB1 allele associations in an Albanian patient population with rheumatoid arthriti... DisGeNET Detail
Several DRB 1 alleles are associated with susceptibility to and severity of rheumatoid arthritis. DisGeNET Detail
Thus, this study identified a negative association of DRB1*13:02 with Japanese RA; our findings supp... DisGeNET Detail
In the presence of SE, the DRB1(∗)04:05 and HLA-DRB4(∗)01 were associated with RA, and the DRB3(∗)03... DisGeNET Detail
Brief Report: Main Contribution of DRB1*04:05 Among the Shared Epitope Alleles and Involvement of DR... DisGeNET Detail
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DNA typing of HLA-A, -C, -B, AND -DRB1 in the children with autism in the Republic of Macedonia. DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs10947345 dbSNP
Genome
hg19
Position
chr2:178,977,164-178,994,383
Variant Type
snv
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