chr16:68737292:> Detail (hg38)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr16:68,771,195-68,869,440 |
| hg38 | chr16:68,737,292-68,835,537 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| 0.169 | squamous cell carcinoma | We show that the loss of both Cdh1 and Tgfbr2 in both models is sufficient to in... | BeFree,CTD_human,GAD,LHGDN | 25233932 | Detail |
| 0.014 | Carcinoma, Transitional Cell | NA | BeFree,GAD,LHGDN | Detail | |
| 0.120 | Neoplastic Cell Transformation | NA | CTD_human | Detail | |
| 0.001 | Malignant tumor of cervix | NA | BeFree | Detail | |
| 0.003 | Uterine Cervical Neoplasm | NA | LHGDN | Detail | |
| <0.001 | Congenital chromosomal disease | NA | BeFree | Detail | |
| 0.005 | cleft lip | NA | GAD | Detail | |
| 0.005 | cleft palate | NA | BeFree,GAD | Detail | |
| 0.124 | ulcerative colitis | NA | BeFree,CTD_human,GAD | Detail | |
| 0.005 | Colonic Neoplasms | NA | LHGDN | Detail | |
| 0.008 | colorectal carcinoma | Contribution of cyclin D1 (CCND1) and E-cadherin (CDH1) alterations to colorecta... | BeFree | 25146682 | Detail |
| 0.164 | Colorectal Neoplasms | NA | BeFree,CTD_human,GAD,LHGDN | Detail | |
| 0.003 | Crohn Disease | NA | BeFree,GAD | Detail | |
| 0.126 | adenoid cystic carcinoma | NA | BeFree,CTD_human,LHGDN | Detail | |
| <0.001 | Cyst | NA | BeFree | Detail | |
| <0.001 | Cytomegalovirus Infections | NA | BeFree | Detail | |
| 0.003 | Eczema | NA | LHGDN | Detail | |
| 0.123 | Endometrial Neoplasms | Further, Cdh1(d/d)Trp53(d/d) tumors in 12-month-old mice were highly aggressive,... | BeFree,CTD_human,LHGDN | 24998851 | Detail |
| 0.009 | endometriosis | NA | BeFree,LHGDN | Detail | |
| <0.001 | Ependymoma | NA | BeFree | Detail | |
| 0.008 | Esophageal Neoplasms | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | Fanconi anemia | Forty-two deleterious germline mutations were identified in 21 genes of 34 patie... | BeFree | 25927356 | Detail |
| 0.008 | gallbladder neoplasm | NA | LHGDN | Detail | |
| <0.001 | gastrinoma | NA | BeFree | Detail | |
| 0.006 | gastritis | NA | BeFree,LHGDN | Detail | |
| 0.005 | Glaucoma, Open-Angle | NA | GAD,LHGDN | Detail | |
| <0.001 | Glioma | NA | BeFree | Detail | |
| 0.002 | Head and Neck Neoplasms | NA | GAD | Detail | |
| <0.001 | hepatitis B | NA | BeFree | Detail | |
| <0.001 | Hepatitis, Chronic | NA | BeFree | Detail | |
| 0.003 | Hyperplasia | NA | LHGDN | Detail | |
| 0.017 | breast carcinoma | Ten SNPs (rs2075555 in COL1A1, rs12652447 in FBXL17, rs10941679 in 5p12/MRPS30, ... | BeFree | 24528085 | Detail |
| 0.026 | Malignant neoplasm of breast | Ten SNPs (rs2075555 in COL1A1, rs12652447 in FBXL17, rs10941679 in 5p12/MRPS30, ... | BeFree | 24528085 | Detail |
| 0.003 | Inflammation | NA | LHGDN | Detail | |
| <0.001 | irritable bowel syndrome | NA | BeFree | Detail | |
| 0.003 | Kidney Neoplasm | NA | BeFree,GAD | Detail | |
| <0.001 | Krukenberg Tumor | Both the primary tumor and ovarian metastasis have common biallelic loss-of-func... | BeFree | 25315765 | Detail |
| 0.005 | Laryngeal neoplasm | NA | GAD,LHGDN | Detail | |
| 0.003 | Fibroid Tumor | NA | BeFree,GAD | Detail | |
| <0.001 | leiomyosarcoma | NA | BeFree | Detail | |
| <0.001 | leukemia | NA | BeFree | Detail | |
| <0.001 | chronic lymphocytic leukemia | NA | BeFree | Detail | |
| 0.001 | Leukemia, Myelocytic, Acute | NA | BeFree | Detail | |
| <0.001 | Myeloid Leukemia, Chronic | NA | BeFree | Detail | |
| 0.002 | Liver neoplasms | NA | GAD | Detail | |
| 0.120 | Liver Neoplasms, Experimental | NA | CTD_human | Detail | |
| 0.002 | Chronic Obstructive Airway Disease | NA | GAD | Detail | |
| 0.094 | Lung Neoplasms | NA | LHGDN,RGD | Detail | |
| 0.003 | Lymphatic Metastasis | NA | BeFree,LHGDN | Detail | |
| <0.001 | lymphoma | The combination of LRP12 and CDH1 methylation could successfully discriminate be... | BeFree | 25226156 | Detail |
| 0.055 | Malignant neoplasm of stomach | Early-onset diffuse gastric cancer associated with a de novo large genomic delet... | BeFree,GAD | 23812922 | Detail |
| 0.055 | Malignant neoplasm of stomach | Cell adhesion was affected by mutations of CDH1 in 2 GCs. | BeFree,GAD | 24510342 | Detail |
| 0.055 | Malignant neoplasm of stomach | Moreover, germline mutations in the E-cadherin gene (CDH1) causing loss of E-cad... | BeFree,GAD | 24742175 | Detail |
| 0.055 | Malignant neoplasm of stomach | The present results indicated that the methylation of p16, CDH1, MGMT, and hMLH1... | BeFree,GAD | 24816738 | Detail |
| 0.055 | Malignant neoplasm of stomach | Presymptomatic identification of CDH1 germline mutation in a healthy korean indi... | BeFree,GAD | 25187893 | Detail |
| 0.055 | Malignant neoplasm of stomach | Lack of association between the CDH1 polymorphism and gastric cancer susceptibil... | BeFree,GAD | 25599647 | Detail |
| 0.055 | Malignant neoplasm of stomach | The risk of development of gastric cancer is high in families affected b-y these... | BeFree,GAD | 25638682 | Detail |
| 0.055 | Malignant neoplasm of stomach | Detection of CDH1 gene variants in early-onset diffuse gastric cancer in Chinese... | BeFree,GAD | 25648022 | Detail |
| 0.055 | Malignant neoplasm of stomach | Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencin... | BeFree,GAD | 25874772 | Detail |
| 0.055 | Malignant neoplasm of stomach | The clinicopathological significance of CDH1 in gastric cancer: a meta-analysis ... | BeFree,GAD | 25926721 | Detail |
| 0.055 | Malignant neoplasm of stomach | CDH1 germ-line missense mutation identified by multigene sequencing in a family ... | BeFree,GAD | 25981591 | Detail |
| 0.055 | Malignant neoplasm of stomach | TP53 mutation, allelic deletion of the APC gene and nuclear staining of β-cateni... | BeFree,GAD | 26033320 | Detail |
| 0.055 | Malignant neoplasm of stomach | Patients with gastric cancer and germline CDH1 mutations had shorter survival ti... | BeFree,GAD | 26072394 | Detail |
| 0.055 | Malignant neoplasm of stomach | CDH1 was downregulated in diffuse-type GC tissues (P=0.0007) and showed a negati... | BeFree,GAD | 26136075 | Detail |
| 0.120 | Animal Mammary Neoplasms | NA | CTD_human | Detail | |
| 0.120 | Mammary Neoplasms, Experimental | NA | CTD_human | Detail | |
| <0.001 | medulloblastoma | NA | BeFree | Detail | |
| 0.012 | melanoma | NA | BeFree,LHGDN | Detail | |
| 0.006 | meningioma | NA | BeFree,GAD,LHGDN | Detail | |
| 0.120 | Mesothelioma | NA | CTD_human | Detail | |
| 0.005 | Metaplasia | NA | LHGDN | Detail | |
| <0.001 | Monoclonal Gammopathy of Undetermined Significance | NA | BeFree | Detail | |
| 0.002 | Mouth Neoplasms | NA | GAD | Detail | |
| <0.001 | multiple myeloma | NA | BeFree | Detail | |
| 0.120 | Mycoplasma Infections | NA | CTD_human | Detail | |
| 0.002 | Nasopharyngeal Neoplasms | NA | GAD | Detail | |
| 0.120 | Neoplasm Invasiveness | NA | CTD_human | Detail | |
| 0.177 | Neoplasm Metastasis | Further, Cdh1(d/d)Trp53(d/d) tumors in 12-month-old mice were highly aggressive,... | BeFree,CTD_human,LHGDN | 24998851 | Detail |
| 0.177 | Neoplasm Metastasis | We highlighted the importance of nuclear HIF-1α in the biology of metastasis for... | BeFree,CTD_human,LHGDN | 25447306 | Detail |
| 0.177 | Neoplasm Metastasis | Down regulation of CDH1, may lead to dysfunction of the cell-cell adhesion syste... | BeFree,CTD_human,LHGDN | 25599647 | Detail |
| 0.177 | Neoplasm Metastasis | The aim of this study was to examine the effect of C-Terminal EH domain-containi... | BeFree,CTD_human,LHGDN | 25758127 | Detail |
| 0.177 | Neoplasm Metastasis | However, for the cancer cells that have already entered the blood circulation, a... | BeFree,CTD_human,LHGDN | 25810011 | Detail |
| 0.177 | Neoplasm Metastasis | The de-regulation of both of miR-29b/c and DNMT3A leads to the epigenetic silenc... | BeFree,CTD_human,LHGDN | 25874772 | Detail |
| 0.177 | Neoplasm Metastasis | Loss of CDH1 function contributes to cancer progression by increasing proliferat... | BeFree,CTD_human,LHGDN | 25926721 | Detail |
| 0.177 | Neoplasm Metastasis | Loss of CDH1 function contributes to the progression of cancer by increasing pro... | BeFree,CTD_human,LHGDN | 25931811 | Detail |
| 0.177 | Neoplasm Metastasis | In studying the possible mechanism by which Cyclin B1 suppresses colorectal canc... | BeFree,CTD_human,LHGDN | 25962181 | Detail |
| 0.002 | Neoplasm Recurrence, Local | NA | GAD | Detail | |
| <0.001 | nephroblastoma | NA | BeFree | Detail | |
| 0.120 | Nerve Degeneration | NA | CTD_human | Detail | |
| <0.001 | neurilemmoma | We identified a subset of genes that were upregulated in meningiomas and schwann... | BeFree | 25333347 | Detail |
| <0.001 | Nodule | NA | BeFree | Detail | |
| 0.002 | ocular hypertension | NA | GAD | Detail | |
| <0.001 | oligodendroglioma | NA | BeFree | Detail | |
| <0.001 | osteosarcoma | NA | BeFree | Detail | |
| 0.002 | ovarian carcinoma | Clinical importance and therapeutic implication of E-cadherin gene methylation i... | BeFree | 24973953 | Detail |
| 0.003 | Paget Disease Extramammary | NA | LHGDN | Detail | |
| 0.136 | Pancreatic Neoplasm | NA | CTD_human,GAD,LHGDN | Detail | |
| <0.001 | pemphigus vulgaris | NA | BeFree | Detail | |
| 0.002 | Pharyngeal Neoplasms | NA | GAD | Detail | |
| <0.001 | pituitary adenoma | NA | BeFree | Detail | |
| <0.001 | Pituitary Diseases | NA | BeFree | Detail | |
| 0.003 | Pituitary Neoplasms | NA | LHGDN | Detail | |
| 0.011 | Adenomatous Polyposis Coli | NA | BeFree,LHGDN | Detail | |
| <0.001 | polyps | NA | BeFree | Detail | |
| 0.121 | Precancerous Conditions | NA | BeFree,CTD_human | Detail | |
| 0.003 | prolactinoma | NA | LHGDN | Detail | |
| 0.172 | Prostatic Neoplasms | NA | BeFree,CTD_human,LHGDN | Detail | |
| 0.003 | pseudomyxoma peritonei | NA | LHGDN | Detail | |
| 0.080 | pulmonary fibrosis | NA | RGD | Detail | |
| 0.003 | Rectal Neoplasms | NA | LHGDN | Detail | |
| 0.002 | Respiratory Syncytial Virus Infections | NA | GAD | Detail | |
| 0.120 | Salivary Gland Neoplasms | NA | CTD_human | Detail | |
| <0.001 | seminoma | NA | BeFree | Detail | |
| 0.006 | synovial sarcoma | NA | BeFree,LHGDN | Detail | |
| <0.001 | thymoma | NA | BeFree | Detail | |
| 0.003 | Thyroid Neoplasm | NA | BeFree,LHGDN | Detail | |
| 0.002 | Tooth Abnormalities | NA | GAD | Detail | |
| 0.002 | Uterine Neoplasms | NA | GAD | Detail | |
| <0.001 | Vulvar Diseases | NA | BeFree | Detail | |
| 0.125 | Helicobacter Infections | NA | CTD_human,GAD | Detail | |
| <0.001 | B-Cell Lymphomas | NA | BeFree | Detail | |
| <0.001 | High Grade Lymphoma (neoplasm) | NA | BeFree | Detail | |
| <0.001 | Li-Fraumeni syndrome | NA | BeFree | Detail | |
| <0.001 | Chronic cholecystitis | NA | BeFree | Detail | |
| <0.001 | Epstein-Barr Virus Infections | NA | BeFree | Detail | |
| <0.001 | Squamous cell carcinoma of lung | NA | BeFree | Detail | |
| <0.001 | Adenocarcinoma of lung (disorder) | NA | BeFree | Detail | |
| 0.001 | esophageal carcinoma | NA | BeFree | Detail | |
| 0.002 | low tension glaucoma | NA | GAD | Detail | |
| <0.001 | Malignant neoplasm of mouth | The role of E-cadherin down-regulation in oral cancer: CDH1 gene expression and ... | BeFree | 24274398 | Detail |
| <0.001 | Malignant neoplasm of nasopharynx | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of gallbladder | NA | BeFree | Detail | |
| <0.001 | Secondary malignant neoplasm of bone | We highlighted the importance of nuclear HIF-1α in the biology of metastasis for... | BeFree | 25447306 | Detail |
| <0.001 | endometriosis of ovary | NA | BeFree | Detail | |
| 0.003 | Tumor Progression | Loss of CDH1 function contributes to cancer progression by increasing proliferat... | BeFree | 25926721 | Detail |
| <0.001 | Sarcoma, Spindle Cell | NA | BeFree | Detail | |
| <0.001 | hepatoblastoma | By contrast, the expression levels of epithelial-cadherin (E-cadherin) and cytos... | BeFree | 25695679 | Detail |
| <0.001 | sebaceous adenocarcinoma | NA | BeFree | Detail | |
| 0.003 | Carcinoma, Endometrioid | NA | BeFree,LHGDN | Detail | |
| 0.131 | Carcinoma, Lobular | Those with the CDH1 mutation have an 80% and 60% cumulative lifetime risk of dev... | BeFree,CTD_human,LHGDN | 25089230 | Detail |
| 0.006 | mucoepidermoid carcinoma | NA | BeFree,LHGDN | Detail | |
| 0.005 | Carcinoma, Signet Ring Cell | Hereditary diffuse gastric cancer (HDGC), characterized by susceptibility to gas... | BeFree,LHGDN | 24037103 | Detail |
| 0.003 | cholangiocarcinoma | NA | BeFree,LHGDN | Detail | |
| <0.001 | verrucous carcinoma | NA | BeFree | Detail | |
| 0.003 | Neoplasms, Neuroepithelial | NA | BeFree,LHGDN | Detail | |
| <0.001 | Lip and oral cavity carcinoma | The role of E-cadherin down-regulation in oral cancer: CDH1 gene expression and ... | BeFree | 24274398 | Detail |
| <0.001 | Metastatic malignant neoplasm to brain | NA | BeFree | Detail | |
| <0.001 | pancreatic carcinoma | NA | BeFree | Detail | |
| <0.001 | Gastrointestinal Stromal Tumors | NA | BeFree | Detail | |
| <0.001 | Cancer of Nasopharynx | NA | BeFree | Detail | |
| <0.001 | Hereditary pancreatitis | NA | BeFree | Detail | |
| <0.001 | Anaplastic thyroid carcinoma | NA | BeFree | Detail | |
| <0.001 | Papillary thyroid carcinoma | NA | BeFree | Detail | |
| 0.008 | Malignant neoplasm of lung | ABCG2 localizes to the nucleus and modulates CDH1 expression in lung cancer cell... | BeFree,GAD | 25810011 | Detail |
| 0.008 | Malignant neoplasm of lung | Clinicopathological significance and potential drug targeting of CDH1 in lung ca... | BeFree,GAD | 25931811 | Detail |
| 0.120 | Disease Progression | NA | CTD_human | Detail | |
| <0.001 | spongiotic dermatitis | NA | BeFree | Detail | |
| <0.001 | Childhood asthma | NA | BeFree | Detail | |
| <0.001 | Carcinoma breast stage IV | NA | BeFree | Detail | |
| <0.001 | Cancer of Head and Neck | Both of them control E-cadherin expression at transcription level and subsequent... | BeFree | 25161999 | Detail |
| <0.001 | Liver and Intrahepatic Biliary Tract Carcinoma | NA | BeFree | Detail | |
| <0.001 | Lobular carcinoma in situ of breast | NA | BeFree | Detail | |
| 0.002 | Invasive lobular breast carcinoma | NA | BeFree | Detail | |
| <0.001 | Squamous cell carcinoma of esophagus | NA | BeFree | Detail | |
| <0.001 | Adenocarcinoma Of Esophagus | NA | BeFree | Detail | |
| 0.003 | Transitional cell carcinoma of bladder | NA | BeFree,GAD | Detail | |
| <0.001 | Conventional (Clear Cell) Renal Cell Carcinoma | NA | BeFree | Detail | |
| <0.001 | Solid tumour | NA | BeFree | Detail | |
| 0.120 | Prostatic Intraepithelial Neoplasias | NA | CTD_human | Detail | |
| 0.003 | cervix carcinoma | NA | BeFree,GAD | Detail | |
| <0.001 | Intraepithelial Squamous Cell Carcinoma | NA | BeFree | Detail | |
| <0.001 | Fibrolamellar hepatocellular carcinoma | NA | BeFree | Detail | |
| <0.001 | Papillary cystic tumor | NA | BeFree | Detail | |
| <0.001 | Non-infiltrating lobular carcinoma | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of liver | NA | BeFree | Detail | |
| <0.001 | intrahepatic cholangiocarcinoma | NA | BeFree | Detail | |
| <0.001 | malignant mesothelioma | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of pancreas | NA | BeFree | Detail | |
| <0.001 | Squamous cell carcinoma of tongue | NA | BeFree | Detail | |
| 0.001 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | CDH1 hypermethylation is correlated with HP status, indicating that it plays a m... | BeFree | 25926721 | Detail |
| 0.036 | Malignant neoplasm of prostate | NA | BeFree,GAD | Detail | |
| <0.001 | Hematologic Neoplasms | NA | BeFree | Detail | |
| <0.001 | nephrolithiasis | NA | BeFree | Detail | |
| <0.001 | Ichthyosis bullosa of Siemens | NA | BeFree | Detail | |
| 0.123 | endometrial carcinoma | The role of WWOX tumor suppressor gene in the regulation of EMT process via regu... | BeFree,CLINVAR | 25892250 | Detail |
| 0.003 | Malignant neoplasm of esophagus | NA | BeFree,GAD | Detail | |
| <0.001 | Thyroid carcinoma | NA | BeFree | Detail | |
| <0.001 | Primary infertility | NA | BeFree | Detail | |
| <0.001 | Tonsillar Carcinoma | NA | BeFree | Detail | |
| <0.001 | Osteosarcoma of bone | NA | BeFree | Detail | |
| <0.001 | Carcinoma of larynx | As compared with cells treated with negative control shRNA, epithelial cadherin ... | BeFree | 24831064 | Detail |
| 0.013 | Carcinogenesis | The CDH1 gene plays an important role during carcinogenesis and craniofacial mor... | BeFree | 24838934 | Detail |
| 0.013 | Carcinogenesis | Further, Cdh1(d/d)Trp53(d/d) tumors in 12-month-old mice were highly aggressive,... | BeFree | 24998851 | Detail |
| 0.013 | Carcinogenesis | Cyclin D1 (CCND1) and E-cadherin (CDH1) are two important genes of the β-catenin... | BeFree | 25146682 | Detail |
| 0.013 | Carcinogenesis | To investigate if the coordinated loss of Cdh1 and Tgfbr2 is sufficient to induc... | BeFree | 25233932 | Detail |
| 0.013 | Carcinogenesis | The results from the current study indicate that the hypermethylation frequency ... | BeFree | 25758052 | Detail |
| <0.001 | Leukemogenesis | NA | BeFree | Detail | |
| <0.001 | Tumor Initiation | NA | BeFree | Detail | |
| 0.006 | prostate carcinoma | NA | BeFree | Detail | |
| 0.001 | Epithelial ovarian cancer | NA | BeFree | Detail | |
| 0.017 | breast carcinoma | Notwithstanding its relevance, how SLPI affects E-cadherin in breast cancer is s... | BeFree,GAD | 25039920 | Detail |
| 0.017 | breast carcinoma | δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promo... | BeFree,GAD | 25315069 | Detail |
| 0.017 | breast carcinoma | Cell adhesion was affected by mutations of CDH1 in 1 breast cancer. | BeFree,GAD | 25591616 | Detail |
| 0.017 | breast carcinoma | With mutational or epigenetic inactivation of the cell adhesion molecule E-cadhe... | BeFree,GAD | 25757734 | Detail |
| 0.017 | breast carcinoma | Kaplan-Meier survival analysis showed that decreased expression of EHD2 and E-ca... | BeFree,GAD | 25758127 | Detail |
| 0.004 | Carcinoma of lung | ABCG2 localizes to the nucleus and modulates CDH1 expression in lung cancer cell... | BeFree | 25810011 | Detail |
| 0.004 | Carcinoma of lung | Clinicopathological significance and potential drug targeting of CDH1 in lung ca... | BeFree | 25931811 | Detail |
| 0.003 | Malignant neoplasm of gastrointestinal tract | NA | BeFree,GAD | Detail | |
| 0.002 | Secondary malignant neoplasm of lymph node | CDH1 germline variants are present in EODGC patients in Chinese population, but ... | BeFree | 25648022 | Detail |
| 0.002 | Secondary malignant neoplasm of lymph node | However, there were no correlations between CDH1 promoter methylation and clinic... | BeFree | 25931811 | Detail |
| 0.002 | colon carcinoma | NA | BeFree | Detail | |
| 0.045 | stomach carcinoma | Early-onset diffuse gastric cancer associated with a de novo large genomic delet... | BeFree | 23812922 | Detail |
| 0.045 | stomach carcinoma | Cell adhesion was affected by mutations of CDH1 in 2 GCs. | BeFree | 24510342 | Detail |
| 0.045 | stomach carcinoma | Moreover, germline mutations in the E-cadherin gene (CDH1) causing loss of E-cad... | BeFree | 24742175 | Detail |
| 0.045 | stomach carcinoma | The present results indicated that the methylation of p16, CDH1, MGMT, and hMLH1... | BeFree | 24816738 | Detail |
| 0.045 | stomach carcinoma | Those with the CDH1 mutation have an 80% and 60% cumulative lifetime risk of dev... | BeFree | 25089230 | Detail |
| 0.045 | stomach carcinoma | Presymptomatic identification of CDH1 germline mutation in a healthy korean indi... | BeFree | 25187893 | Detail |
| 0.045 | stomach carcinoma | Lack of association between the CDH1 polymorphism and gastric cancer susceptibil... | BeFree | 25599647 | Detail |
| 0.045 | stomach carcinoma | The risk of development of gastric cancer is high in families affected b-y these... | BeFree | 25638682 | Detail |
| 0.045 | stomach carcinoma | Detection of CDH1 gene variants in early-onset diffuse gastric cancer in Chinese... | BeFree | 25648022 | Detail |
| 0.045 | stomach carcinoma | Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencin... | BeFree | 25874772 | Detail |
| 0.045 | stomach carcinoma | The clinicopathological significance of CDH1 in gastric cancer: a meta-analysis ... | BeFree | 25926721 | Detail |
| 0.045 | stomach carcinoma | CDH1 germ-line missense mutation identified by multigene sequencing in a family ... | BeFree | 25981591 | Detail |
| 0.045 | stomach carcinoma | TP53 mutation, allelic deletion of the APC gene and nuclear staining of β-cateni... | BeFree | 26033320 | Detail |
| 0.045 | stomach carcinoma | Patients with gastric cancer and germline CDH1 mutations had shorter survival ti... | BeFree | 26072394 | Detail |
| 0.045 | stomach carcinoma | CDH1 was downregulated in diffuse-type GC tissues (P=0.0007) and showed a negati... | BeFree | 26136075 | Detail |
| 0.002 | Carcinoma of bladder | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of kidney | NA | BeFree | Detail | |
| <0.001 | Poorly differentiated carcinoma | Among diffuse type GCs, SRCCs showed lower level of methylation for GDNF, RORA, ... | BeFree | 24953529 | Detail |
| <0.001 | biliary tract cancer | NA | BeFree | Detail | |
| <0.001 | Well Differentiated Oligodendroglioma | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm tonsil | NA | BeFree | Detail | |
| <0.001 | Cleft lip with or without cleft palate | Nucleotide variants of the cancer predisposing gene CDH1 and the risk of non-syn... | BeFree | 24838934 | Detail |
| 0.002 | Helicobacter pylori infection | NA | BeFree | Detail | |
| <0.001 | Carcinoma in situ of uterine cervix | NA | BeFree | Detail | |
| 0.001 | Invasive breast carcinoma | NA | BeFree | Detail | |
| <0.001 | breast adenocarcinoma | NA | BeFree | Detail | |
| <0.001 | lobular neoplasia | NA | BeFree | Detail | |
| <0.001 | Metastatic Prostate Carcinoma | NA | BeFree | Detail | |
| <0.001 | precancerous lesions | NA | BeFree | Detail | |
| <0.001 | Ovarian adenocarcinoma | NA | BeFree | Detail | |
| <0.001 | Colorectal cancer metastatic | NA | BeFree | Detail | |
| <0.001 | Hurthle Cell Tumor | NA | BeFree | Detail | |
| 0.122 | Invasive Ductal Breast Carcinoma | NA | BeFree,CTD_human | Detail | |
| <0.001 | Monoclonal Gammapathies | NA | BeFree | Detail | |
| 0.004 | Malignant neoplasm of ovary | Clinical importance and therapeutic implication of E-cadherin gene methylation i... | BeFree,GAD | 24973953 | Detail |
| <0.001 | Squamous cell carcinoma of the head and neck | NA | BeFree | Detail | |
| 0.004 | Ductal Carcinoma | NA | BeFree,LHGDN | Detail | |
| <0.001 | Adenoma of large intestine | NA | BeFree | Detail | |
| 0.001 | Hereditary Malignant Neoplasm | NA | BeFree | Detail | |
| <0.001 | Hereditary Nonpolyposis Colorectal Cancer | NA | BeFree | Detail | |
| <0.001 | Invasive Carcinoma | NA | BeFree | Detail | |
| <0.001 | pancreatic ductal adenocarcinoma | NA | BeFree | Detail | |
| <0.001 | Gastric Diffuse Large B-Cell Lymphoma | NA | BeFree | Detail | |
| <0.001 | Signet-ring cell adenocarcinoma gastric | NA | BeFree | Detail | |
| <0.001 | Sporadic Breast Carcinoma | NA | BeFree | Detail | |
| <0.001 | Carcinoma of urinary bladder, superficial | NA | BeFree | Detail | |
| <0.001 | Epithelioma | NA | BeFree | Detail | |
| <0.001 | Oncocytic Neoplasm | NA | BeFree | Detail | |
| <0.001 | renal carcinoma | NA | BeFree | Detail | |
| <0.001 | Cardiomyopathy, Familial Idiopathic | NA | BeFree | Detail | |
| 0.154 | Mammary Neoplasms | NA | BeFree,CTD_human,LHGDN | Detail | |
| <0.001 | oxyphilic adenoma | NA | BeFree | Detail | |
| <0.001 | Hepatocarcinogenesis | NA | BeFree | Detail | |
| <0.001 | Type II Endometrial Adenocarcinoma | These results indicate that absence of CDH1 and TP53 in endometrial cells initia... | BeFree | 24998851 | Detail |
| 0.171 | colorectal cancer | Contribution of cyclin D1 (CCND1) and E-cadherin (CDH1) alterations to colorecta... | BeFree,GAD,GWASCAT | 25146682 | Detail |
| 0.389 | hereditary diffuse gastric cancer | Hereditary diffuse gastric cancer in a Japanese family with a large deletion inv... | BeFree,CLINVAR,ORPHANET,UNIPROT | 24037103 | Detail |
| 0.389 | hereditary diffuse gastric cancer | Approximately 30% of HDGC cases are caused by a germline mutation involving the ... | BeFree,CLINVAR,ORPHANET,UNIPROT | 25089230 | Detail |
| 0.389 | hereditary diffuse gastric cancer | CDH1, which encodes the protein E-cadherin, is the only gene whose mutations are... | BeFree,CLINVAR,ORPHANET,UNIPROT | 25187893 | Detail |
| 0.389 | hereditary diffuse gastric cancer | Hereditary diffuse gastric cancer is an autosomic dominant syndrome associated w... | BeFree,CLINVAR,ORPHANET,UNIPROT | 25332147 | Detail |
| 0.389 | hereditary diffuse gastric cancer | Mutations in the E-cadherin gene, CDH1, account for 40% of the most common form ... | BeFree,CLINVAR,ORPHANET,UNIPROT | 25340522 | Detail |
| 0.389 | hereditary diffuse gastric cancer | The risk of development of gastric cancer is high in families affected b-y these... | BeFree,CLINVAR,ORPHANET,UNIPROT | 25638682 | Detail |
| 0.389 | hereditary diffuse gastric cancer | Both results (functional and clinical) support the conclusion that the CDH1 c.48... | BeFree,CLINVAR,ORPHANET,UNIPROT | 25771876 | Detail |
| 0.389 | hereditary diffuse gastric cancer | In this family, the mutation c.1849G>A in the CDH1 gene is not related to HDGC n... | BeFree,CLINVAR,ORPHANET,UNIPROT | 25981591 | Detail |
| 0.389 | hereditary diffuse gastric cancer | Accuracy of Hereditary Diffuse Gastric Cancer Testing Criteria and Outcomes in P... | BeFree,CLINVAR,ORPHANET,UNIPROT | 26072394 | Detail |
| 0.001 | Non-Neoplastic Disorder | NA | BeFree | Detail | |
| <0.001 | Meningioma, benign, no ICD-O subtype | NA | BeFree | Detail | |
| 0.002 | uterine corpus cancer | The role of WWOX tumor suppressor gene in the regulation of EMT process via regu... | BeFree | 25892250 | Detail |
| <0.001 | low grade glioma | NA | BeFree | Detail | |
| 0.098 | liver carcinoma | Furthermore, our results show that MTBP and E-cadherin protein expression are in... | BeFree,GAD,LHGDN,RGD | 26280083 | Detail |
| 0.120 | Prostate cancer, familial | NA | BeFree,CTD_human | Detail | |
| 0.002 | Nasopharyngeal carcinoma | NA | BeFree | Detail | |
| <0.001 | Pancreatic Intraductal Papillary Mucinous Neoplasm, Gastric-Type | NA | BeFree | Detail | |
| 0.120 | Gastric cancer, familial diffuse, and cleft lip with or without cleft palate | NA | CLINVAR | Detail | |
| <0.001 | Small Intestinal Neuroendocrine Tumor | Similar analyses in the SI-NET cell lines HC45 and CNDT2 showed methylation for ... | BeFree | 24762809 | Detail |
| <0.001 | FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | Forty-two deleterious germline mutations were identified in 21 genes of 34 patie... | BeFree | 25927356 | Detail |
| 0.007 | Breast cancer, lobular | The CDH1 gene, which encodes the cell-to-cell adhesion protein E-cadherin, is fr... | BeFree | 25777964 | Detail |
| 0.007 | Breast cancer, lobular | No CDH1 mutations were found in the 67 families whose members developed intestin... | BeFree | 26072394 | Detail |
| <0.001 | Secondary malignant neoplasm of ovary | Both the primary tumor and ovarian metastasis have common biallelic loss-of-func... | BeFree | 25315765 | Detail |
| <0.001 | Intracranial glioma | NA | BeFree | Detail | |
| 0.005 | Infection | NA | LHGDN | Detail | |
| 0.017 | adenocarcinoma | NA | BeFree,GAD,LHGDN | Detail | |
| 0.001 | adenoma | NA | BeFree | Detail | |
| <0.001 | Anaplasia | NA | BeFree | Detail | |
| 0.006 | asthma | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | Astrocytoma | NA | BeFree | Detail | |
| 0.003 | atherosclerosis | NA | LHGDN | Detail | |
| 0.012 | Malignant neoplasm of urinary bladder | NA | BeFree,GAD | Detail | |
| 0.211 | Bladder Neoplasm | NA | CTD_human,GAD,LHGDN,RGD | Detail | |
| <0.001 | Blast Phase | NA | BeFree | Detail | |
| 0.003 | Brain Neoplasms | NA | LHGDN | Detail | |
| 0.026 | Malignant neoplasm of breast | Notwithstanding its relevance, how SLPI affects E-cadherin in breast cancer is s... | BeFree,GAD | 25039920 | Detail |
| 0.026 | Malignant neoplasm of breast | δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promo... | BeFree,GAD | 25315069 | Detail |
| 0.026 | Malignant neoplasm of breast | Cell adhesion was affected by mutations of CDH1 in 1 breast cancer. | BeFree,GAD | 25591616 | Detail |
| 0.026 | Malignant neoplasm of breast | With mutational or epigenetic inactivation of the cell adhesion molecule E-cadhe... | BeFree,GAD | 25757734 | Detail |
| 0.026 | Malignant neoplasm of breast | Kaplan-Meier survival analysis showed that decreased expression of EHD2 and E-ca... | BeFree,GAD | 25758127 | Detail |
| 0.002 | Bronchiolitis, Viral | NA | GAD | Detail | |
| <0.001 | Carcinoid Tumor | NA | BeFree | Detail | |
| 0.002 | Malignant tumor of colon | NA | BeFree | Detail | |
| 0.002 | Malignant neoplasm of endometrium | The role of WWOX tumor suppressor gene in the regulation of EMT process via regu... | BeFree | 25892250 | Detail |
| 0.002 | Non-small cell lung carcinoma | The epithelial hMENA11a isoform was expressed in NSCLC lines expressing E-CADHER... | BeFree | 25373410 | Detail |
| 0.002 | Non-small cell lung carcinoma | The results from the current study indicate that the hypermethylation frequency ... | BeFree | 25758052 | Detail |
| <0.001 | Carcinoma, Papillary | NA | BeFree | Detail | |
| 0.003 | renal cell carcinoma | NA | BeFree,GAD | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| We show that the loss of both Cdh1 and Tgfbr2 in both models is sufficient to induce squamous cell c... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Contribution of cyclin D1 (CCND1) and E-cadherin (CDH1) alterations to colorectal cancer susceptibil... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Further, Cdh1(d/d)Trp53(d/d) tumors in 12-month-old mice were highly aggressive, and metastasized to... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Forty-two deleterious germline mutations were identified in 21 genes of 34 patients, including 18 (1... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Ten SNPs (rs2075555 in COL1A1, rs12652447 in FBXL17, rs10941679 in 5p12/MRPS30, rs11878583 in ZNF577... | DisGeNET | Detail |
| Ten SNPs (rs2075555 in COL1A1, rs12652447 in FBXL17, rs10941679 in 5p12/MRPS30, rs11878583 in ZNF577... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Both the primary tumor and ovarian metastasis have common biallelic loss-of-function of both the CDH... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The combination of LRP12 and CDH1 methylation could successfully discriminate between the vast major... | DisGeNET | Detail |
| Early-onset diffuse gastric cancer associated with a de novo large genomic deletion of CDH1 gene. | DisGeNET | Detail |
| Cell adhesion was affected by mutations of CDH1 in 2 GCs. | DisGeNET | Detail |
| Moreover, germline mutations in the E-cadherin gene (CDH1) causing loss of E-cadherin function (adhe... | DisGeNET | Detail |
| The present results indicated that the methylation of p16, CDH1, MGMT, and hMLH1 was both frequent a... | DisGeNET | Detail |
| Presymptomatic identification of CDH1 germline mutation in a healthy korean individual with family h... | DisGeNET | Detail |
| Lack of association between the CDH1 polymorphism and gastric cancer susceptibility: a meta-analysis... | DisGeNET | Detail |
| The risk of development of gastric cancer is high in families affected b-y these syndromes, but only... | DisGeNET | Detail |
| Detection of CDH1 gene variants in early-onset diffuse gastric cancer in Chinese patients. | DisGeNET | Detail |
| Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencing of the CDH1 gene, ... | DisGeNET | Detail |
| The clinicopathological significance of CDH1 in gastric cancer: a meta-analysis and systematic revie... | DisGeNET | Detail |
| CDH1 germ-line missense mutation identified by multigene sequencing in a family with no history of d... | DisGeNET | Detail |
| TP53 mutation, allelic deletion of the APC gene and nuclear staining of β-catenin are frequently det... | DisGeNET | Detail |
| Patients with gastric cancer and germline CDH1 mutations had shorter survival times than patients wh... | DisGeNET | Detail |
| CDH1 was downregulated in diffuse-type GC tissues (P=0.0007) and showed a negative relationship with... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Further, Cdh1(d/d)Trp53(d/d) tumors in 12-month-old mice were highly aggressive, and metastasized to... | DisGeNET | Detail |
| We highlighted the importance of nuclear HIF-1α in the biology of metastasis for the mesenchymal-epi... | DisGeNET | Detail |
| Down regulation of CDH1, may lead to dysfunction of the cell-cell adhesion system, resulting in incr... | DisGeNET | Detail |
| The aim of this study was to examine the effect of C-Terminal EH domain-containing protein 2 (EHD2) ... | DisGeNET | Detail |
| However, for the cancer cells that have already entered the blood circulation, an increased level of... | DisGeNET | Detail |
| The de-regulation of both of miR-29b/c and DNMT3A leads to the epigenetic silencing of CDH1 and cont... | DisGeNET | Detail |
| Loss of CDH1 function contributes to cancer progression by increasing proliferation, invasion, and/o... | DisGeNET | Detail |
| Loss of CDH1 function contributes to the progression of cancer by increasing proliferation, invasion... | DisGeNET | Detail |
| In studying the possible mechanism by which Cyclin B1 suppresses colorectal cancer invasion and meta... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We identified a subset of genes that were upregulated in meningiomas and schwannomas when compared t... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Clinical importance and therapeutic implication of E-cadherin gene methylation in human ovarian canc... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The role of E-cadherin down-regulation in oral cancer: CDH1 gene expression and epigenetic blockage. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We highlighted the importance of nuclear HIF-1α in the biology of metastasis for the mesenchymal-epi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Loss of CDH1 function contributes to cancer progression by increasing proliferation, invasion, and/o... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| By contrast, the expression levels of epithelial-cadherin (E-cadherin) and cytosolic accumulation of... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Those with the CDH1 mutation have an 80% and 60% cumulative lifetime risk of developing diffuse type... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Hereditary diffuse gastric cancer (HDGC), characterized by susceptibility to gastric signet ring cel... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The role of E-cadherin down-regulation in oral cancer: CDH1 gene expression and epigenetic blockage. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| ABCG2 localizes to the nucleus and modulates CDH1 expression in lung cancer cells. | DisGeNET | Detail |
| Clinicopathological significance and potential drug targeting of CDH1 in lung cancer: a meta-analysi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Both of them control E-cadherin expression at transcription level and subsequently hinder the overal... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| CDH1 hypermethylation is correlated with HP status, indicating that it plays a more important role i... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The role of WWOX tumor suppressor gene in the regulation of EMT process via regulation of CDH1-ZEB1-... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| As compared with cells treated with negative control shRNA, epithelial cadherin (E-cadherin) express... | DisGeNET | Detail |
| The CDH1 gene plays an important role during carcinogenesis and craniofacial morphogenesis. | DisGeNET | Detail |
| Further, Cdh1(d/d)Trp53(d/d) tumors in 12-month-old mice were highly aggressive, and metastasized to... | DisGeNET | Detail |
| Cyclin D1 (CCND1) and E-cadherin (CDH1) are two important genes of the β-catenin/LEF pathway that is... | DisGeNET | Detail |
| To investigate if the coordinated loss of Cdh1 and Tgfbr2 is sufficient to induce tumorigenesis in v... | DisGeNET | Detail |
| The results from the current study indicate that the hypermethylation frequency of E-cadherin in NSC... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Notwithstanding its relevance, how SLPI affects E-cadherin in breast cancer is still unknown. | DisGeNET | Detail |
| δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer... | DisGeNET | Detail |
| Cell adhesion was affected by mutations of CDH1 in 1 breast cancer. | DisGeNET | Detail |
| With mutational or epigenetic inactivation of the cell adhesion molecule E-cadherin (CDH1) being con... | DisGeNET | Detail |
| Kaplan-Meier survival analysis showed that decreased expression of EHD2 and E-cadherin exhibited a s... | DisGeNET | Detail |
| ABCG2 localizes to the nucleus and modulates CDH1 expression in lung cancer cells. | DisGeNET | Detail |
| Clinicopathological significance and potential drug targeting of CDH1 in lung cancer: a meta-analysi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| CDH1 germline variants are present in EODGC patients in Chinese population, but they are mainly miss... | DisGeNET | Detail |
| However, there were no correlations between CDH1 promoter methylation and clinicopathological charac... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Early-onset diffuse gastric cancer associated with a de novo large genomic deletion of CDH1 gene. | DisGeNET | Detail |
| Cell adhesion was affected by mutations of CDH1 in 2 GCs. | DisGeNET | Detail |
| Moreover, germline mutations in the E-cadherin gene (CDH1) causing loss of E-cadherin function (adhe... | DisGeNET | Detail |
| The present results indicated that the methylation of p16, CDH1, MGMT, and hMLH1 was both frequent a... | DisGeNET | Detail |
| Those with the CDH1 mutation have an 80% and 60% cumulative lifetime risk of developing diffuse type... | DisGeNET | Detail |
| Presymptomatic identification of CDH1 germline mutation in a healthy korean individual with family h... | DisGeNET | Detail |
| Lack of association between the CDH1 polymorphism and gastric cancer susceptibility: a meta-analysis... | DisGeNET | Detail |
| The risk of development of gastric cancer is high in families affected b-y these syndromes, but only... | DisGeNET | Detail |
| Detection of CDH1 gene variants in early-onset diffuse gastric cancer in Chinese patients. | DisGeNET | Detail |
| Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencing of the CDH1 gene, ... | DisGeNET | Detail |
| The clinicopathological significance of CDH1 in gastric cancer: a meta-analysis and systematic revie... | DisGeNET | Detail |
| CDH1 germ-line missense mutation identified by multigene sequencing in a family with no history of d... | DisGeNET | Detail |
| TP53 mutation, allelic deletion of the APC gene and nuclear staining of β-catenin are frequently det... | DisGeNET | Detail |
| Patients with gastric cancer and germline CDH1 mutations had shorter survival times than patients wh... | DisGeNET | Detail |
| CDH1 was downregulated in diffuse-type GC tissues (P=0.0007) and showed a negative relationship with... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Among diffuse type GCs, SRCCs showed lower level of methylation for GDNF, RORA, MINT25 and KLF7, and... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Nucleotide variants of the cancer predisposing gene CDH1 and the risk of non-syndromic cleft lip wit... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Clinical importance and therapeutic implication of E-cadherin gene methylation in human ovarian canc... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| These results indicate that absence of CDH1 and TP53 in endometrial cells initiates chronic inflamma... | DisGeNET | Detail |
| Contribution of cyclin D1 (CCND1) and E-cadherin (CDH1) alterations to colorectal cancer susceptibil... | DisGeNET | Detail |
| Hereditary diffuse gastric cancer in a Japanese family with a large deletion involving CDH1. | DisGeNET | Detail |
| Approximately 30% of HDGC cases are caused by a germline mutation involving the E-cadherin (CDH1) ge... | DisGeNET | Detail |
| CDH1, which encodes the protein E-cadherin, is the only gene whose mutations are associated with HDG... | DisGeNET | Detail |
| Hereditary diffuse gastric cancer is an autosomic dominant syndrome associated with E-cadherin prote... | DisGeNET | Detail |
| Mutations in the E-cadherin gene, CDH1, account for 40% of the most common form of familial gastric ... | DisGeNET | Detail |
| The risk of development of gastric cancer is high in families affected b-y these syndromes, but only... | DisGeNET | Detail |
| Both results (functional and clinical) support the conclusion that the CDH1 c.48 G>C (Q16H) variant ... | DisGeNET | Detail |
| In this family, the mutation c.1849G>A in the CDH1 gene is not related to HDGC nor ILC. | DisGeNET | Detail |
| Accuracy of Hereditary Diffuse Gastric Cancer Testing Criteria and Outcomes in Patients With a Germl... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The role of WWOX tumor suppressor gene in the regulation of EMT process via regulation of CDH1-ZEB1-... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Furthermore, our results show that MTBP and E-cadherin protein expression are inversely correlated i... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Similar analyses in the SI-NET cell lines HC45 and CNDT2 showed methylation for CDH1 and WIF1 and/or... | DisGeNET | Detail |
| Forty-two deleterious germline mutations were identified in 21 genes of 34 patients, including 18 (1... | DisGeNET | Detail |
| The CDH1 gene, which encodes the cell-to-cell adhesion protein E-cadherin, is frequently mutated in ... | DisGeNET | Detail |
| No CDH1 mutations were found in the 67 families whose members developed intestinal-type gastric canc... | DisGeNET | Detail |
| Both the primary tumor and ovarian metastasis have common biallelic loss-of-function of both the CDH... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Notwithstanding its relevance, how SLPI affects E-cadherin in breast cancer is still unknown. | DisGeNET | Detail |
| δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer... | DisGeNET | Detail |
| Cell adhesion was affected by mutations of CDH1 in 1 breast cancer. | DisGeNET | Detail |
| With mutational or epigenetic inactivation of the cell adhesion molecule E-cadherin (CDH1) being con... | DisGeNET | Detail |
| Kaplan-Meier survival analysis showed that decreased expression of EHD2 and E-cadherin exhibited a s... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The role of WWOX tumor suppressor gene in the regulation of EMT process via regulation of CDH1-ZEB1-... | DisGeNET | Detail |
| The epithelial hMENA11a isoform was expressed in NSCLC lines expressing E-CADHERIN and was alternati... | DisGeNET | Detail |
| The results from the current study indicate that the hypermethylation frequency of E-cadherin in NSC... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- dbSNP
- rs12964873 dbSNP
- Genome
- hg38
- Position
- chr16:68,737,292-68,835,537
- Variant Type
- snv
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