chr4:89011302:> Detail (hg19)

Information

Genome

Assembly Position
hg19 chr4:89,011,302-89,152,780
hg38 chr4:88,090,150-88,231,628 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.006 squamous cell carcinoma NA BeFree,GAD,LHGDN Detail
0.002 Cardiovascular Diseases NA GAD Detail
0.002 brain ischemia NA GAD Detail
<0.001 Primary biliary cirrhosis NA BeFree Detail
<0.001 cholelithiasis NA BeFree Detail
<0.001 cholestasis NA BeFree Detail
0.004 choriocarcinoma NA BeFree,LHGDN Detail
<0.001 ulcerative colitis NA BeFree Detail
0.003 Colonic Neoplasms NA LHGDN Detail
0.002 colorectal carcinoma Exploiting a novel miR-519c-HuR-ABCG2 regulatory pathway to overcome chemoresist... BeFree 26386386 Detail
0.127 Colorectal Neoplasms NA CTD_human,GAD,LHGDN Detail
<0.001 Coronary Arteriosclerosis Associations of the uric acid related genetic variants in SLC2A9 and ABCG2 loci ... BeFree 25634581 Detail
0.003 Coronary heart disease Associations of the uric acid related genetic variants in SLC2A9 and ABCG2 loci ... BeFree,GAD 25634581 Detail
<0.001 Crohn Disease NA BeFree Detail
0.002 Deafness NA GAD Detail
<0.001 Delirium NA BeFree Detail
<0.001 Demyelinating Diseases NA BeFree Detail
0.120 dental caries NA GWASCAT Detail
0.080 Diabetes Mellitus, Experimental NA RGD Detail
<0.001 Diabetes Mellitus, Non-Insulin-Dependent NA BeFree Detail
0.006 diarrhea NA BeFree,GAD Detail
<0.001 Experimental Autoimmune Encephalomyelitis NA BeFree Detail
<0.001 Bacterial Endocarditis NA BeFree Detail
<0.001 Ependymoma NA BeFree Detail
0.001 epilepsy NA BeFree Detail
0.002 Exanthema NA GAD Detail
<0.001 fibrosarcoma NA BeFree Detail
<0.001 Folic Acid Deficiency NA BeFree Detail
0.002 glioblastoma The mRNA levels of stemness genes such as Nanog, CD133, and ABCG2 were much high... BeFree 25359730 Detail
0.002 glioblastoma Oct-3/4 modulates the drug-resistant phenotype of glioblastoma cells through exp... BeFree 25644290 Detail
0.004 Glioma NA BeFree,GAD Detail
0.142 gout NA BeFree,GAD,GWASCAT Detail
0.005 Head and Neck Neoplasms NA GAD Detail
0.002 Hearing Loss, Partial NA GAD Detail
<0.001 Heart failure NA BeFree Detail
<0.001 congestive heart failure NA BeFree Detail
<0.001 hepatitis A NA BeFree Detail
0.001 HIV Infections NA BeFree Detail
<0.001 Hypercholesterolemia, Familial Statin treatment decreased ABCG2 expression and function in patients with FH. BeFree 25084202 Detail
<0.001 Inflammatory Bowel Diseases NA BeFree Detail
<0.001 ischemia NA BeFree Detail
<0.001 Transient ischemia NA BeFree Detail
<0.001 Jaundice, Chronic Idiopathic NA BeFree Detail
0.002 leukemia Resistance to daunorubicin, imatinib, or nilotinib depends on expression levels ... BeFree 24954033 Detail
0.002 leukemia Patients with ABCG2 overexpression at AML diagnosis have lower leukemia free sur... BeFree 26059733 Detail
0.001 chronic lymphocytic leukemia NA BeFree Detail
0.002 Acute lymphocytic leukemia NA BeFree Detail
0.001 Leukemia, Lymphocytic, Acute, L1 NA BeFree Detail
0.028 Leukemia, Myelocytic, Acute A median fluorescence intensity ratio (MFIR) which measures the efflux of mitoxa... BeFree,GAD,LHGDN 26002514 Detail
0.028 Leukemia, Myelocytic, Acute ABCG2 overexpression in patients with acute myeloid leukemia: Impact on stem cel... BeFree,GAD,LHGDN 26059733 Detail
<0.001 myeloid leukemia NA BeFree Detail
0.011 Myeloid Leukemia, Chronic The aim of the study was to investigate any possible influence of polymorphisms ... BeFree,GAD 24589908 Detail
0.002 Leukemia, Myeloid, Chronic-Phase NA GAD Detail
<0.001 leukopenia With respect to hematological and nonhematological toxicities, SNPs in drug tran... BeFree 25340731 Detail
<0.001 liver cirrhosis NA BeFree Detail
<0.001 Liver Cirrhosis, Alcoholic NA BeFree Detail
0.120 Biliary cirrhosis NA CTD_human Detail
<0.001 Liver neoplasms NA BeFree Detail
0.013 Lung Neoplasms NA GAD,LHGDN Detail
0.003 lymphoma NA BeFree,GAD Detail
<0.001 macular degeneration NA BeFree Detail
<0.001 malaria A female gametocyte-specific ABC transporter plays a role in lipid metabolism in... BeFree 25198203 Detail
0.002 Malignant neoplasm of stomach Our in vitro and in vivo experiments demonstrated that CD133(+)  ABCG2(+) cells ... BeFree 25727099 Detail
0.002 Malignant neoplasm of stomach SHH-GLI and its downstream effector ABCG2 could be better targeted to possibly i... BeFree 26276718 Detail
<0.001 melioidosis NA BeFree Detail
0.001 Mental Retardation NA BeFree Detail
0.003 Mesothelioma NA BeFree,GAD Detail
<0.001 Mild Mental Retardation NA BeFree Detail
0.004 multiple myeloma NA BeFree,LHGDN Detail
0.003 multiple sclerosis NA BeFree,GAD Detail
0.002 myocardial infarction NA GAD Detail
<0.001 Nausea With respect to hematological and nonhematological toxicities, SNPs in drug tran... BeFree 25340731 Detail
0.002 Neoplasm Metastasis Resistant cells expressed higher levels of genes coding for cancer stem cell mar... BeFree 25725450 Detail
0.002 Neoplasm Metastasis We propose a novel role for nuclear ABCG2 that functions as a transcription regu... BeFree 25810011 Detail
0.002 Neoplasm Metastasis Well-characterized clones of metastatic site-derived aggressive cells (MSDACs) f... BeFree 25888913 Detail
0.002 Neoplasm Recurrence, Local NA GAD Detail
0.002 Pathologic Neovascularization NA GAD Detail
0.120 nervous system disorder NA CTD_human Detail
<0.001 neuroblastoma NA BeFree Detail
<0.001 neuromyelitis optica NA BeFree Detail
0.008 neutropenia With respect to hematological and nonhematological toxicities, SNPs in drug tran... BeFree,GAD 25340731 Detail
0.003 obesity ABCG2 dysfunction was observed in 53.3% of the population investigated, and its ... BeFree,GAD 24909660 Detail
<0.001 osteosarcoma It was concluded that the elevated expression of SATB1 in U2OS cells contributes... BeFree 25317073 Detail
0.003 ovarian carcinoma Under the condition of serum-free medium culture, the expression levels of CDl33... BeFree 25491627 Detail
0.003 ovarian carcinoma We confirmed that knockdown of BAF57 decreased BCRP expression in ovarian cancer... BeFree 25611552 Detail
0.002 Pancreatic Neoplasm NA GAD Detail
<0.001 Pituitary Diseases NA BeFree Detail
0.002 Pleural Neoplasms NA GAD Detail
0.006 Prostatic Neoplasms NA BeFree,LHGDN Detail
0.002 pseudoxanthoma elasticum Mutations in the ABC transporter ABCC6 were recently identified as cause of Pseu... BeFree 25265166 Detail
0.003 psoriasis NA BeFree,GAD Detail
0.080 Reperfusion Injury NA RGD Detail
<0.001 retinal degeneration NA BeFree Detail
<0.001 Retinal Diseases NA BeFree Detail
<0.001 retinitis pigmentosa NA BeFree Detail
<0.001 retinoblastoma NA BeFree Detail
<0.001 Dermatologic disorders NA BeFree Detail
0.080 status epilepticus NA RGD Detail
0.003 Cerebrovascular accident NA BeFree,GAD Detail
<0.001 Tangier disease NA BeFree Detail
0.003 Thyroid Neoplasm NA BeFree,LHGDN Detail
0.120 Adverse reaction to drug NA CTD_human Detail
0.002 Genitourinary Neoplasms NA GAD Detail
<0.001 Vascular Diseases NA BeFree Detail
<0.001 viral hepatitis NA BeFree Detail
<0.001 Virus Diseases NA BeFree Detail
0.001 intestinal volvulus NA BeFree Detail
0.006 B-Cell Lymphomas NA BeFree,LHGDN Detail
0.123 diffuse large B-cell lymphoma NA BeFree,CTD_human,GAD Detail
<0.001 cerebral amyloid angiopathy NA BeFree Detail
<0.001 Encephalopathies NA BeFree Detail
0.001 acute leukemia NA BeFree Detail
<0.001 Small cell carcinoma of lung NA BeFree Detail
<0.001 Sensory neuropathy With respect to hematological and nonhematological toxicities, SNPs in drug tran... BeFree 25340731 Detail
0.001 Adenocarcinoma of lung (disorder) Cholesterol reduces the sensitivity to platinum-based chemotherapy via upregulat... BeFree 25603057 Detail
<0.001 Malignant neoplasm of tongue NA BeFree Detail
<0.001 Malignant tumor of peritoneum NA BeFree Detail
<0.001 Malignant neoplasm of brain NA BeFree Detail
0.002 adrenoleukodystrophy The human genetic disorder X-linked adrenoleukodystrophy (X-ALD) is caused by mu... BeFree 25118695 Detail
0.002 adrenoleukodystrophy X-linked Adrenoleukodystrophy (X-ALD), an inherited peroxisomal metabolic neurod... BeFree 25393703 Detail
<0.001 Colitis, Ischemic NA BeFree Detail
0.080 erythropoietic protoporphyria NA BeFree,MGD Detail
<0.001 HELLP syndrome Total bile acids in the maternal and fetal compartment in relation to placental ... BeFree 25446997 Detail
<0.001 Dermatitis, Phototoxic NA BeFree Detail
<0.001 Tumor Progression NA BeFree Detail
<0.001 Lichen Planus, Oral NA BeFree Detail
0.003 Carcinoma, Neuroendocrine NA BeFree,LHGDN Detail
0.002 Squamous Cell Neoplasms NA GAD Detail
0.001 Adult Acute Myeloblastic Leukemia NA BeFree Detail
<0.001 pediatric acute myeloblastic leukemia NA BeFree Detail
<0.001 Hereditary sideroblastic anemia NA BeFree Detail
0.002 Neurotoxicity Syndromes NA GAD Detail
<0.001 Retinal damage NA BeFree Detail
<0.001 Zinc deficiency NA BeFree Detail
0.002 pancreatic carcinoma NA BeFree Detail
0.005 Gastrointestinal Stromal Tumors Association of ABCG2 polymorphism with clinical efficacy of imatinib in patients... BeFree,GAD,LHGDN 25417047 Detail
<0.001 Anaplastic thyroid carcinoma NA BeFree Detail
<0.001 Medullary carcinoma of thyroid NA BeFree Detail
<0.001 Papillary thyroid carcinoma NA BeFree Detail
<0.001 Harlequin Fetus NA BeFree Detail
0.012 Malignant neoplasm of lung We further found that the PI3K/Akt inhibitor LY294002 down-regulated BCRP expres... BeFree,GAD 25479544 Detail
0.012 Malignant neoplasm of lung ABCG2 localizes to the nucleus and modulates CDH1 expression in lung cancer cell... BeFree,GAD 25810011 Detail
<0.001 age related macular degeneration NA BeFree Detail
0.009 Neoplasm, Residual NA BeFree,LHGDN Detail
<0.001 Chronic tophaceous gout NA BeFree Detail
<0.001 Progressive intrahepatic cholestasis (disorder) NA BeFree Detail
<0.001 Cholestasis of pregnancy Up-regulation of placental ABCG2 may play an important role in protecting the fo... BeFree 25099365 Detail
<0.001 Myoclonic Epilepsy, Juvenile NA BeFree Detail
<0.001 Tuberculosis of intestines NA BeFree Detail
<0.001 Infectious colitis NA BeFree Detail
<0.001 Prostate cancer recurrent NA BeFree Detail
<0.001 Squamous cell carcinoma of esophagus NA BeFree Detail
<0.001 childhood acute megakaryocytic leukemia (M7) NA BeFree Detail
<0.001 gallbladder adenocarcinoma NA BeFree Detail
0.003 Solid tumour NA BeFree,GAD Detail
<0.001 stage, ovarian epithelial cancer NA BeFree Detail
<0.001 Peroxisomal Disorders NA BeFree Detail
<0.001 Senile Plaques NA BeFree Detail
0.003 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse NA BeFree,LHGDN Detail
<0.001 Autosomal recessive retinitis pigmentosa NA BeFree Detail
<0.001 MRSA - Methicillin resistant Staphylococcus aureus infection NA BeFree Detail
<0.001 Multiple malignancy This novel CRE site plays a central role in mediating BCRP gene expression in se... BeFree 25615818 Detail
0.002 Malignant neoplasm of pancreas NA BeFree Detail
0.003 Malignant neoplasm of prostate NA BeFree,GAD Detail
<0.001 Hematopoietic Neoplasms NA BeFree Detail
<0.001 Hematologic Neoplasms NA BeFree Detail
<0.001 Nevus elasticus NA BeFree Detail
<0.001 Secondary malignant neoplasm of liver NA BeFree Detail
<0.001 hiv-infection/aids NA BeFree Detail
<0.001 Overweight ABCG2 dysfunction was observed in 53.3% of the population investigated, and its ... BeFree 24909660 Detail
<0.001 Recurrent tumor Our findings suggest that the overexpression of ABCG2 and the expression of stem... BeFree 25427584 Detail
<0.001 Recurrent tumor Therefore, the increased expression of stem cell markers and ABCG2 protein may i... BeFree 25633829 Detail
<0.001 Metabolic syndrome X We studied the associations between the serum uric acid concentration and the fo... BeFree 24827988 Detail
<0.001 tongue carcinoma NA BeFree Detail
<0.001 Osteosarcoma of bone It was concluded that the elevated expression of SATB1 in U2OS cells contributes... BeFree 25317073 Detail
<0.001 Carcinogenesis In conclusion, this study found that ABCC2 and ABCG2 expression levels were alte... BeFree 25793771 Detail
<0.001 prostate carcinoma NA BeFree Detail
0.002 Epithelial ovarian cancer NA BeFree Detail
0.017 breast carcinoma Inhibition or upregulation of HIF-1α affects breast cancer cell expression of BC... BeFree 24472707 Detail
0.005 Carcinoma of lung We further found that the PI3K/Akt inhibitor LY294002 down-regulated BCRP expres... BeFree 25479544 Detail
0.005 Carcinoma of lung ABCG2 localizes to the nucleus and modulates CDH1 expression in lung cancer cell... BeFree 25810011 Detail
<0.001 Secondary malignant neoplasm of lymph node NA BeFree Detail
<0.001 heavy drinking ABCG2 dysfunction was observed in 53.3% of the population investigated, and its ... BeFree 24909660 Detail
0.002 colon carcinoma The role of the NRF2-BCRP pathway in Pba-PDT response was further confirmed in c... BeFree 25226504 Detail
0.002 colon carcinoma ABCG2-meditated multidrug resistance and tumor-initiating capacity of side popul... BeFree 25427584 Detail
0.003 stomach carcinoma Our in vitro and in vivo experiments demonstrated that CD133(+)  ABCG2(+) cells ... BeFree 25727099 Detail
0.003 stomach carcinoma SHH-GLI and its downstream effector ABCG2 could be better targeted to possibly i... BeFree 26276718 Detail
<0.001 Central neuroblastoma NA BeFree Detail
0.002 Serum uric acid observed NA GAD Detail
0.014 hyperuricemia ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion an... BeFree,GAD 24441388 Detail
0.014 hyperuricemia This study aimed to test the hypothesis that the ABCG2 gout risk allele 141 K pr... BeFree,GAD 24476385 Detail
0.014 hyperuricemia Because ABCG2 dysfunctional diplotypes were commonly observed in both Caucasians... BeFree,GAD 24869748 Detail
0.014 hyperuricemia Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia pro... BeFree,GAD 24909660 Detail
0.014 hyperuricemia Two important pathways determining hyperuricemia have been confirmed (renal and ... BeFree,GAD 25889045 Detail
0.005 Malignant neoplasm of kidney NA GAD Detail
<0.001 gout tophaceous NA BeFree Detail
<0.001 adult acute lymphocytic leukemia NA BeFree Detail
<0.001 malignant pleural mesothelioma NA BeFree Detail
<0.001 Myelosuppression NA BeFree Detail
<0.001 Retinal Dystrophies NA BeFree Detail
<0.001 placental choriocarcinoma NA BeFree Detail
<0.001 breast adenocarcinoma NA BeFree Detail
0.002 Drug-Induced Liver Injury NA GAD Detail
<0.001 Cardiomyopathies NA BeFree Detail
0.006 ovarian neoplasm NA BeFree,GAD,LHGDN Detail
0.002 Genomic Instability NA GAD Detail
<0.001 Ischemic stroke NA BeFree Detail
<0.001 Colorectal cancer metastatic We assessed 44 gene polymorphisms in 16 genes (TYMS, MTHFR, GSTP1, GSTM1, GSTT1,... BeFree 25677447 Detail
0.080 Arthritis, Experimental NA RGD Detail
<0.001 Gastrooesophageal cancer We assessed 44 gene polymorphisms in 16 genes (TYMS, MTHFR, GSTP1, GSTM1, GSTT1,... BeFree 25677447 Detail
0.002 Mental Retardation, X-Linked NA BeFree Detail
0.004 Malignant neoplasm of ovary Under the condition of serum-free medium culture, the expression levels of CDl33... BeFree,GAD 25491627 Detail
0.004 Malignant neoplasm of ovary We confirmed that knockdown of BAF57 decreased BCRP expression in ovarian cancer... BeFree,GAD 25611552 Detail
0.017 Malignant neoplasm of breast Genetic polymorphisms of glutathione S-transferase (GST) genes including GSTT1 p... BeFree 17180579 Detail
0.017 breast carcinoma Genetic polymorphisms of glutathione S-transferase (GST) genes including GSTT1 p... BeFree 17180579 Detail
<0.001 Skin toxicity NA BeFree Detail
0.120 Squamous cell carcinoma of the head and neck NA BeFree,CTD_human Detail
<0.001 dysembryoplastic neuroepithelial tumor NA BeFree Detail
<0.001 Primary Effusion Lymphoma NA BeFree Detail
<0.001 Adenoma of large intestine High ABCC2 and low ABCG2 gene expression are early events in the colorectal aden... BeFree 25793771 Detail
<0.001 pancreatic ductal adenocarcinoma NA BeFree Detail
<0.001 renal carcinoma ABCG2 expression was low in all renal carcinoma cell lines, and was suppressed o... BeFree 25455500 Detail
0.002 hearing impairment NA GAD Detail
<0.001 Severe diarrhea NA BeFree Detail
0.140 Mammary Neoplasms In particular, we analysed the association of NAC response and pre- and post-NAC... BeFree,CTD_human,LHGDN 24736530 Detail
<0.001 Hippocampal sclerosis NA BeFree Detail
<0.001 Xenograft Model NA BeFree Detail
0.009 colorectal cancer Exploiting a novel miR-519c-HuR-ABCG2 regulatory pathway to overcome chemoresist... BeFree,GAD 26386386 Detail
<0.001 Phototoxicity NA BeFree Detail
<0.001 infective endocarditis NA BeFree Detail
<0.001 Chronic Kidney Diseases Intestinal urate secretion may be increased at CKD state partially by upregulati... BeFree 25515305 Detail
<0.001 Glioblastoma multiforme The mRNA levels of stemness genes such as Nanog, CD133, and ABCG2 were much high... BeFree 25359730 Detail
<0.001 Cirrhosis NA BeFree Detail
<0.001 androgen independent prostate cancer NA BeFree Detail
<0.001 tumor vasculature NA BeFree Detail
<0.001 Non-Neoplastic Disorder NA BeFree Detail
<0.001 ANEMIA, SIDEROBLASTIC, AND SPINOCEREBELLAR ATAXIA NA BeFree Detail
<0.001 Creatine deficiency, X-linked NA BeFree Detail
<0.001 PHOTOPAROXYSMAL RESPONSE 1 NA BeFree Detail
<0.001 coronary artery disease NA BeFree Detail
0.120 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma NA BeFree,CTD_human Detail
0.009 Precursor Cell Lymphoblastic Leukemia Lymphoma NA BeFree,GAD,LHGDN Detail
<0.001 Diarrhea due to drug NA BeFree Detail
0.006 liver carcinoma Yet median expression of OCT1, OCT3, and MDR1 in HCC was significantly lower (1.... BeFree,LHGDN 25231932 Detail
0.006 liver carcinoma We evaluated the effect of GNT on the expression and activity of P-gp, MRP2, MRP... BeFree,LHGDN 25781341 Detail
<0.001 Mental Retardation, X-Linked 1 NA BeFree Detail
<0.001 Nasopharyngeal carcinoma NA BeFree Detail
<0.001 Plaque, Amyloid NA BeFree Detail
<0.001 Ischemic Cerebrovascular Accident NA BeFree Detail
<0.001 Triple Negative Breast Neoplasms Upon exposure of TNBC to MSC-secreted conditioned medium (CM), noticeable drug r... BeFree 25140317 Detail
<0.001 Cytogenetically normal acute myeloid leukemia NA BeFree Detail
0.002 Hearing Loss NA GAD Detail
0.005 adenocarcinoma NA GAD,LHGDN Detail
0.120 adenoma Furthermore, ABCG2 mRNA levels were significantly lower in adenomas and carcinom... BeFree,CTD_human 25793771 Detail
0.005 Alzheimer's disease NA GAD Detail
<0.001 Anaplasia NA BeFree Detail
<0.001 arteriosclerosis NA BeFree Detail
0.120 rheumatoid arthritis NA CTD_human Detail
<0.001 atherosclerosis NA BeFree Detail
0.003 Brain Neoplasms Critical role of ABCG2 in ALA-photodynamic diagnosis and therapy of human brain ... BeFree,GAD 25640271 Detail
0.017 Malignant neoplasm of breast Inhibition or upregulation of HIF-1α affects breast cancer cell expression of BC... BeFree 24472707 Detail
0.002 Malignant tumor of colon ABCG2-meditated multidrug resistance and tumor-initiating capacity of side popul... BeFree 25427584 Detail
0.001 renal cell carcinoma ABCG2 expression was low in all renal carcinoma cell lines, and was suppressed o... BeFree 25455500 Detail
Annotation

Annotations

DescrptionSourceLinks
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Exploiting a novel miR-519c-HuR-ABCG2 regulatory pathway to overcome chemoresistance in colorectal c... DisGeNET Detail
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Associations of the uric acid related genetic variants in SLC2A9 and ABCG2 loci with coronary heart ... DisGeNET Detail
Associations of the uric acid related genetic variants in SLC2A9 and ABCG2 loci with coronary heart ... DisGeNET Detail
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The mRNA levels of stemness genes such as Nanog, CD133, and ABCG2 were much higher in the SP cells, ... DisGeNET Detail
Oct-3/4 modulates the drug-resistant phenotype of glioblastoma cells through expression of ATP bindi... DisGeNET Detail
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Statin treatment decreased ABCG2 expression and function in patients with FH. DisGeNET Detail
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Resistance to daunorubicin, imatinib, or nilotinib depends on expression levels of ABCB1 and ABCG2 i... DisGeNET Detail
Patients with ABCG2 overexpression at AML diagnosis have lower leukemia free survival (LFS) and incr... DisGeNET Detail
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A median fluorescence intensity ratio (MFIR) which measures the efflux of mitoxantrone (an ATP Bindi... DisGeNET Detail
ABCG2 overexpression in patients with acute myeloid leukemia: Impact on stem cell transplantation ou... DisGeNET Detail
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The aim of the study was to investigate any possible influence of polymorphisms of transmembrane tra... DisGeNET Detail
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With respect to hematological and nonhematological toxicities, SNPs in drug transporters (ABCB1 and ... DisGeNET Detail
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A female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasit... DisGeNET Detail
Our in vitro and in vivo experiments demonstrated that CD133(+)  ABCG2(+) cells exhibited well-known... DisGeNET Detail
SHH-GLI and its downstream effector ABCG2 could be better targeted to possibly improve the efficacy ... DisGeNET Detail
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With respect to hematological and nonhematological toxicities, SNPs in drug transporters (ABCB1 and ... DisGeNET Detail
Resistant cells expressed higher levels of genes coding for cancer stem cell markers (JARID1B, CD271... DisGeNET Detail
We propose a novel role for nuclear ABCG2 that functions as a transcription regulator and participat... DisGeNET Detail
Well-characterized clones of metastatic site-derived aggressive cells (MSDACs) from a manifold of me... DisGeNET Detail
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With respect to hematological and nonhematological toxicities, SNPs in drug transporters (ABCB1 and ... DisGeNET Detail
ABCG2 dysfunction was observed in 53.3% of the population investigated, and its population-attributa... DisGeNET Detail
It was concluded that the elevated expression of SATB1 in U2OS cells contributes to maintenance of t... DisGeNET Detail
Under the condition of serum-free medium culture, the expression levels of CDl33+, CD117+, ABCG2, Na... DisGeNET Detail
We confirmed that knockdown of BAF57 decreased BCRP expression in ovarian cancer cells by Western bl... DisGeNET Detail
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Mutations in the ABC transporter ABCC6 were recently identified as cause of Pseudoxanthoma elasticum... DisGeNET Detail
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With respect to hematological and nonhematological toxicities, SNPs in drug transporters (ABCB1 and ... DisGeNET Detail
Cholesterol reduces the sensitivity to platinum-based chemotherapy via upregulating ABCG2 in lung ad... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The human genetic disorder X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1... DisGeNET Detail
X-linked Adrenoleukodystrophy (X-ALD), an inherited peroxisomal metabolic neurodegenerative disorder... DisGeNET Detail
NA DisGeNET Detail
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Total bile acids in the maternal and fetal compartment in relation to placental ABCG2 expression in ... DisGeNET Detail
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Association of ABCG2 polymorphism with clinical efficacy of imatinib in patients with gastrointestin... DisGeNET Detail
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We further found that the PI3K/Akt inhibitor LY294002 down-regulated BCRP expression, hence showing ... DisGeNET Detail
ABCG2 localizes to the nucleus and modulates CDH1 expression in lung cancer cells. DisGeNET Detail
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Up-regulation of placental ABCG2 may play an important role in protecting the foetus from high conce... DisGeNET Detail
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This novel CRE site plays a central role in mediating BCRP gene expression in several human cancer c... DisGeNET Detail
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ABCG2 dysfunction was observed in 53.3% of the population investigated, and its population-attributa... DisGeNET Detail
Our findings suggest that the overexpression of ABCG2 and the expression of stem cell surface marker... DisGeNET Detail
Therefore, the increased expression of stem cell markers and ABCG2 protein may interact with each ot... DisGeNET Detail
We studied the associations between the serum uric acid concentration and the following: (i) demogra... DisGeNET Detail
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It was concluded that the elevated expression of SATB1 in U2OS cells contributes to maintenance of t... DisGeNET Detail
In conclusion, this study found that ABCC2 and ABCG2 expression levels were altered already in mild/... DisGeNET Detail
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Inhibition or upregulation of HIF-1α affects breast cancer cell expression of BCRP; AI responsivenes... DisGeNET Detail
We further found that the PI3K/Akt inhibitor LY294002 down-regulated BCRP expression, hence showing ... DisGeNET Detail
ABCG2 localizes to the nucleus and modulates CDH1 expression in lung cancer cells. DisGeNET Detail
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ABCG2 dysfunction was observed in 53.3% of the population investigated, and its population-attributa... DisGeNET Detail
The role of the NRF2-BCRP pathway in Pba-PDT response was further confirmed in colon carcinoma HT29 ... DisGeNET Detail
ABCG2-meditated multidrug resistance and tumor-initiating capacity of side population cells from col... DisGeNET Detail
Our in vitro and in vivo experiments demonstrated that CD133(+)  ABCG2(+) cells exhibited well-known... DisGeNET Detail
SHH-GLI and its downstream effector ABCG2 could be better targeted to possibly improve the efficacy ... DisGeNET Detail
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ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overlo... DisGeNET Detail
This study aimed to test the hypothesis that the ABCG2 gout risk allele 141 K promotes the hyperuric... DisGeNET Detail
Because ABCG2 dysfunctional diplotypes were commonly observed in both Caucasians (16.5%) and African... DisGeNET Detail
Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typica... DisGeNET Detail
Two important pathways determining hyperuricemia have been confirmed (renal and gut excretion of uri... DisGeNET Detail
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We assessed 44 gene polymorphisms in 16 genes (TYMS, MTHFR, GSTP1, GSTM1, GSTT1, DPYD, XRCC1, XRCC3,... DisGeNET Detail
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We assessed 44 gene polymorphisms in 16 genes (TYMS, MTHFR, GSTP1, GSTM1, GSTT1, DPYD, XRCC1, XRCC3,... DisGeNET Detail
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Under the condition of serum-free medium culture, the expression levels of CDl33+, CD117+, ABCG2, Na... DisGeNET Detail
We confirmed that knockdown of BAF57 decreased BCRP expression in ovarian cancer cells by Western bl... DisGeNET Detail
Genetic polymorphisms of glutathione S-transferase (GST) genes including GSTT1 positive/null, GSTM1 ... DisGeNET Detail
Genetic polymorphisms of glutathione S-transferase (GST) genes including GSTT1 positive/null, GSTM1 ... DisGeNET Detail
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High ABCC2 and low ABCG2 gene expression are early events in the colorectal adenoma-carcinoma sequen... DisGeNET Detail
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ABCG2 expression was low in all renal carcinoma cell lines, and was suppressed only by combination t... DisGeNET Detail
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In particular, we analysed the association of NAC response and pre- and post-NAC expression of the m... DisGeNET Detail
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Exploiting a novel miR-519c-HuR-ABCG2 regulatory pathway to overcome chemoresistance in colorectal c... DisGeNET Detail
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Intestinal urate secretion may be increased at CKD state partially by upregulation of intestinal BCR... DisGeNET Detail
The mRNA levels of stemness genes such as Nanog, CD133, and ABCG2 were much higher in the SP cells, ... DisGeNET Detail
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Yet median expression of OCT1, OCT3, and MDR1 in HCC was significantly lower (1.4-, 2.7-, and 2-fold... DisGeNET Detail
We evaluated the effect of GNT on the expression and activity of P-gp, MRP2, MRP3 and BCRP in HCC-de... DisGeNET Detail
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Upon exposure of TNBC to MSC-secreted conditioned medium (CM), noticeable drug resistance against do... DisGeNET Detail
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Furthermore, ABCG2 mRNA levels were significantly lower in adenomas and carcinomas compared to the l... DisGeNET Detail
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Critical role of ABCG2 in ALA-photodynamic diagnosis and therapy of human brain tumor. DisGeNET Detail
Inhibition or upregulation of HIF-1α affects breast cancer cell expression of BCRP; AI responsivenes... DisGeNET Detail
ABCG2-meditated multidrug resistance and tumor-initiating capacity of side population cells from col... DisGeNET Detail
ABCG2 expression was low in all renal carcinoma cell lines, and was suppressed only by combination t... DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386514057 dbSNP
Genome
hg19
Position
chr4:89,011,302-89,152,780
Variant Type
snv
Genome browser