chr4:186990065:> Detail (hg19)

Information

Genome

Assembly Position
hg19 chr4:186,990,065-187,009,227
hg38 chr4:186,068,911-186,088,073 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.006 squamous cell carcinoma Haplotypes in TLR3 gene might be associated with poor prognosis in OSCC patients... BeFree,LHGDN 23796347 Detail
0.003 Cardiomyopathy, Dilated NA BeFree,GAD Detail
0.002 Cardiovascular Diseases NA GAD Detail
<0.001 celiac disease NA BeFree Detail
<0.001 Malignant tumor of cervix However, the C/C genotype for the TLR3 (c.1377 C>T) polymorphism and the Asp/Asp... BeFree 25373689 Detail
<0.001 Cervix Diseases NA BeFree Detail
<0.001 Chikungunya Fever These results demonstrate a key role for TLR3-mediated antibody response to CHIK... BeFree 25452586 Detail
0.003 cholangitis NA BeFree,LHGDN Detail
<0.001 Primary biliary cirrhosis NA BeFree Detail
0.002 chorioamnionitis NA GAD Detail
0.080 colitis NA RGD Detail
<0.001 Non-small cell lung carcinoma Among the 178 SNPs, 24 were significantly associated with NSCLC prognosis in dif... BeFree 21412764 Detail
<0.001 colorectal carcinoma NA BeFree Detail
0.002 Connective Tissue Diseases NA GAD Detail
<0.001 Coronary Arteriosclerosis The expression of TLR4 and TLR3 closely correlated with the severity of coronary... BeFree 24146036 Detail
<0.001 Coronary heart disease The expression of TLR4 and TLR3 closely correlated with the severity of coronary... BeFree 24146036 Detail
0.002 Coxsackievirus Infections NA GAD Detail
<0.001 Crohn Disease NA BeFree Detail
0.002 Cytomegalovirus Infections NA GAD Detail
<0.001 Mental Depression NA BeFree Detail
<0.001 depressive disorder NA BeFree Detail
<0.001 dermatomyositis TLR4 and TLR3, two potent inducers of autophagy, were highly increased in IIM, w... BeFree 25365350 Detail
0.003 Diabetes Mellitus, Insulin-Dependent Toll-like receptor 3 (TLR3) and the development of type 1 diabetes mellitus. BeFree,GAD 25926108 Detail
<0.001 Diabetes Mellitus, Non-Insulin-Dependent Inflammatory unbalance of TLR3 and TLR4 in PCI patients with or without type 2 d... BeFree 24845156 Detail
<0.001 diarrhea NA BeFree Detail
0.005 encephalitis NA BeFree,LHGDN Detail
<0.001 Japanese encephalitis Toll-like receptor-3 gene polymorphism in patients with Japanese encephalitis. BeFree 26298326 Detail
0.004 tick-borne encephalitis Polymorphisms in chemokine receptor 5 and Toll-like receptor 3 genes are risk fa... BeFree,GAD 25226020 Detail
<0.001 encephalomyelitis NA BeFree Detail
0.003 Endometrial Neoplasms NA LHGDN Detail
0.003 endometriosis NA LHGDN Detail
0.003 Toxic Epidermal Necrolysis NA BeFree,GAD Detail
<0.001 esophagitis NA BeFree Detail
0.002 Fetal Diseases NA GAD Detail
0.002 Fetal Membranes, Premature Rupture NA GAD Detail
<0.001 Flushing NA BeFree Detail
0.003 glioblastoma NA LHGDN Detail
0.001 glomerulonephritis NA BeFree Detail
<0.001 IgA glomerulonephritis NA BeFree Detail
<0.001 Severe Dengue The results suggest that TLR3 and TIRAP gene variants influence the risk for DHF... BeFree 25446400 Detail
<0.001 Hemorrhagic Fevers, Viral SNPs significantly associated with eye disease included three different polymorp... BeFree 25756647 Detail
0.006 hepatitis C TLR3 polymorphisms are associated with virologic response to hepatitis C virus (... BeFree,GAD 25766991 Detail
0.006 hepatitis C The present study investigated the prevalence of two single-nucleotide polymorph... BeFree,GAD 25992926 Detail
<0.001 Hepatomegaly NA BeFree Detail
<0.001 genital herpes NA BeFree Detail
0.009 Herpes Simplex Infections TLR3 exhibited an anti-HSV-1 infection capacity via innate immune functions. BeFree,LHGDN 25633775 Detail
0.009 Herpes Simplex Infections The identified IRF3 R285Q amino acid substitution results in impaired IFN respon... BeFree,LHGDN 26216125 Detail
0.005 HIV Infections TLR3 polymorphisms are associated with virologic response to hepatitis C virus (... BeFree,GAD 25766991 Detail
0.002 Hodgkin Disease NA GAD Detail
0.002 Hypersensitivity NA GAD Detail
<0.001 Hypertensive disease In men, TLR1, TLR2, and TLR3 were associated with lipid and TLR8 with hypertensi... BeFree 25657311 Detail
0.010 Inflammation NA GAD,LHGDN Detail
<0.001 Inflammatory Bowel Diseases NA BeFree Detail
0.002 influenza These data suggest that obesity is related to TLR-3 impairment and explain, at l... BeFree 24182768 Detail
0.002 influenza These data show that H1N1 and poly(I:C) can induce αvβ6 integrin-dependent TGFβ ... BeFree 25339175 Detail
<0.001 Kidney Diseases Toll-like receptor 3 (TLR3), a receptor for viral double-stranded RNA, is involv... BeFree 25171218 Detail
<0.001 Kidney Failure, Chronic A functional polymorphism in the promoter region of TLR3 is associated with susc... BeFree 25171218 Detail
0.002 Premature Obstetric Labor NA GAD Detail
<0.001 Leukemia, Myelocytic, Acute NA BeFree Detail
<0.001 Liver diseases Genetic polymorphisms in Toll-like receptor 3 gene are associated with the risk ... BeFree 26024592 Detail
<0.001 Liver neoplasms NA BeFree Detail
<0.001 Lung diseases These data show that H1N1 and poly(I:C) can induce αvβ6 integrin-dependent TGFβ ... BeFree 25339175 Detail
<0.001 Lupus Vulgaris NA BeFree Detail
<0.001 Lupus Erythematosus, Discoid NA BeFree Detail
0.001 Lupus Erythematosus, Systemic This study aimed to demonstrate possible associations between genetic polymorphi... BeFree 24719229 Detail
<0.001 lymphoma NA BeFree Detail
0.006 melanoma NA BeFree,LHGDN Detail
0.003 molluscum contagiosum NA LHGDN Detail
0.005 multiple sclerosis NA BeFree,GAD Detail
0.002 Musculoskeletal Diseases NA GAD Detail
<0.001 myasthenia gravis Next, we investigated if dsRNA signaling pathway involvement could be observed i... BeFree 24440286 Detail
<0.001 Mycoses NA BeFree Detail
0.003 myocarditis NA BeFree,GAD Detail
0.003 myositis NA BeFree,LHGDN Detail
0.003 Nasal Polyps NA BeFree,LHGDN Detail
0.002 Nasopharyngeal Neoplasms NA GAD Detail
0.001 Neoplasm Metastasis For the first time, in the present work, we are convincingly reporting the funct... BeFree 25348355 Detail
<0.001 nephritis NA BeFree Detail
<0.001 neuroblastoma NA BeFree Detail
<0.001 obesity These data suggest that obesity is related to TLR-3 impairment and explain, at l... BeFree 24182768 Detail
0.002 Degenerative polyarthritis NA BeFree Detail
0.080 Peripheral neuropathy NA RGD Detail
<0.001 pneumonia NA BeFree Detail
<0.001 polycythemia vera NA BeFree Detail
<0.001 polyps NA BeFree Detail
0.082 pre-eclampsia NA GAD,RGD Detail
0.002 Pregnancy Complications, Hematologic NA GAD Detail
0.003 Prostatic Neoplasms NA LHGDN Detail
<0.001 pulmonary fibrosis NA BeFree Detail
<0.001 Rabies (disorder) NA BeFree Detail
0.080 Reperfusion Injury NA RGD Detail
<0.001 Respiration Disorders NA BeFree Detail
<0.001 Respiratory Distress Syndrome, Adult NA BeFree Detail
0.006 Respiratory Syncytial Virus Infections NA BeFree,GAD Detail
<0.001 Respiratory Tract Diseases NA BeFree Detail
<0.001 retinal degeneration NA BeFree Detail
<0.001 Rotavirus Infections NA BeFree Detail
<0.001 sarcoidosis A toll-like receptor 3 single nucleotide polymorphism in Japanese patients with ... BeFree 25720507 Detail
<0.001 schizophrenia NA BeFree Detail
<0.001 Septicemia A novel 1,2-benzenediamine derivative FC-99 suppresses TLR3 expression and ameli... BeFree 24903157 Detail
0.002 Dermatologic disorders NA GAD Detail
0.006 Stevens-Johnson syndrome NA BeFree,GAD Detail
0.003 subacute sclerosing panencephalitis NA BeFree,GAD Detail
<0.001 Subarachnoid Hemorrhage NA BeFree Detail
<0.001 thymoma Next, we investigated if dsRNA signaling pathway involvement could be observed i... BeFree 24440286 Detail
0.003 Thyroid Neoplasm NA LHGDN Detail
<0.001 thyroiditis NA BeFree Detail
<0.001 Chagas disease NA BeFree Detail
0.003 Uterine Diseases NA LHGDN Detail
0.011 Virus Diseases The Toll-like receptor 3 (TLR3) gene codes for an endoplasmic receptor of the pa... BeFree,GAD 25926108 Detail
0.003 Leukemia, Feline NA LHGDN Detail
<0.001 Encephalopathies NA BeFree Detail
<0.001 Synovial Cyst NA BeFree Detail
0.001 polymyositis Co-localization between autophagic marker, LC3, and TLR4 and TLR3 was observed n... BeFree 25365350 Detail
<0.001 Sicca Syndrome NA BeFree Detail
0.007 Premature Birth NA GAD Detail
<0.001 Pustular psoriasis NA BeFree Detail
<0.001 acute myocarditis NA BeFree Detail
<0.001 Tumor Progression NA BeFree Detail
<0.001 Adult type dermatomyositis TLR4 and TLR3, two potent inducers of autophagy, were highly increased in IIM, w... BeFree 25365350 Detail
<0.001 pancreatic carcinoma NA BeFree Detail
<0.001 Papillary thyroid carcinoma NA BeFree Detail
<0.001 Hepatitis, Autoimmune NA BeFree Detail
<0.001 coronary stenosis The expression of TLR4 and TLR3 closely correlated with the severity of coronary... BeFree 24146036 Detail
0.012 age related macular degeneration NA BeFree,GAD,LHGDN Detail
<0.001 Sepsis A novel 1,2-benzenediamine derivative FC-99 suppresses TLR3 expression and ameli... BeFree 24903157 Detail
<0.001 Dermatomyositis, Childhood Type Co-localization between autophagic marker, LC3, and TLR4 and TLR3 was observed n... BeFree 25365350 Detail
0.001 Vesicular Stomatitis PCR array analysis revealed that human mast cells up-regulated several anti-vira... BeFree 25550087 Detail
0.001 Vesicular Stomatitis We found that TLR3-ligand polyinosinic-polycytidylic acid and human rhinovirus i... BeFree 26101320 Detail
<0.001 Renal glomerular disease NA BeFree Detail
0.124 Herpes encephalitis Herpes simplex encephalitis (HSE) in children has previously been linked to defe... BeFree,CTD_human 26216125 Detail
<0.001 Rhinovirus infection We found that TLR3-ligand polyinosinic-polycytidylic acid and human rhinovirus i... BeFree 26101320 Detail
<0.001 Adenocarcinoma Of Esophagus NA BeFree Detail
<0.001 cervical squamous cell carcinoma A significant downregulation in the gene expression of TLRs 3, 4 and 5 and upreg... BeFree 26024767 Detail
<0.001 cervix carcinoma However, the C/C genotype for the TLR3 (c.1377 C>T) polymorphism and the Asp/Asp... BeFree 25373689 Detail
0.003 Atrophic NA LHGDN Detail
<0.001 Malignant neoplasm of pancreas NA BeFree Detail
<0.001 Disseminated Malignant Neoplasm NA BeFree Detail
0.001 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
0.003 Malignant neoplasm of prostate NA BeFree,GAD Detail
<0.001 Osteoarthritis, Knee NA BeFree Detail
<0.001 lupus erythematosus NA BeFree Detail
0.003 myocarditis A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the incr... BeFree 23962581 Detail
0.004 tick-borne encephalitis A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the incr... BeFree 23962581 Detail
0.012 age related macular degeneration The genetic association between a variant in the Toll-like receptor 3 (TLR3) gen... BeFree 21712495 Detail
0.011 Virus Diseases Genetic association studies have provided evidence concerning the role of a poly... BeFree 22174453 Detail
0.080 Necrotizing Enterocolitis NA RGD Detail
<0.001 Hepatitis B, Chronic NA BeFree Detail
0.007 Hepatitis C, Chronic NA BeFree,GAD,LHGDN Detail
<0.001 Wheezing Toll-like receptor 3 L412F polymorphisms in infants with bronchiolitis and postb... BeFree 22549436 Detail
0.006 hepatitis C Toll-like receptor 3 L412F polymorphism may protect against acute graft rejectio... BeFree 21839239 Detail
<0.001 bronchiolitis Toll-like receptor 3 L412F polymorphisms in infants with bronchiolitis and postb... BeFree 22549436 Detail
0.003 cutaneous candidiasis The biological significance of TLR3 variant, L412F, in conferring susceptibility... BeFree 22024499 Detail
<0.001 liver cirrhosis Toll-like receptor 3 L412F polymorphism may protect against acute graft rejectio... BeFree 21839239 Detail
<0.001 Chronic candidiasis We have shown here aberrant biological responses mediated by the TLR3 variant re... BeFree 22024499 Detail
<0.001 Geographic Atrophy Toll-like receptor 3 C1234T may protect against geographic atrophy through decre... BeFree 21712495 Detail
<0.001 Idiopathic Pulmonary Fibrosis The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathi... BeFree 24070541 Detail
0.001 prostate carcinoma NA BeFree Detail
0.002 Choroidal Neovascularization NA GAD Detail
<0.001 Hashimoto Disease NA BeFree Detail
<0.001 Sentinel node (disorder) NA BeFree Detail
<0.001 Stage II Colorectal Cancer NA BeFree Detail
0.002 breast carcinoma β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem... BeFree 25257174 Detail
0.002 breast carcinoma Innate adjuvant receptor Toll-like receptor 3 can promote breast cancer through ... BeFree 25348355 Detail
<0.001 colon carcinoma NA BeFree Detail
<0.001 Central neuroblastoma NA BeFree Detail
<0.001 Viral respiratory infection NA BeFree Detail
<0.001 Punctate inner choroidopathy NA BeFree Detail
<0.001 Inclusion Body Myopathy, Sporadic Co-localization between autophagic marker, LC3, and TLR4 and TLR3 was observed n... BeFree 25365350 Detail
0.080 Somatosensory Disorders NA RGD Detail
<0.001 Chronic candidiasis NA BeFree Detail
<0.001 Myocarditis, chronic NA BeFree Detail
<0.001 Cardiomyopathies NA BeFree Detail
<0.001 autoimmune thyroiditis NA BeFree Detail
0.002 Primary infection NOS NA BeFree Detail
0.080 Arthritis, Experimental NA RGD Detail
<0.001 West Nile viral infection Toll-like receptor-3 is dispensable for the innate microRNA response to West Nil... BeFree 25127040 Detail
<0.001 Myxoid cyst NA BeFree Detail
<0.001 Inflammatory disorder TLR3 and TLR4 are known to act as anti-inflammatory and pro-inflammatory factors... BeFree 24845156 Detail
<0.001 Chronic inflammatory disorder Toll-like receptor 3 (TLR3), a receptor for viral double-stranded RNA, is involv... BeFree 25171218 Detail
<0.001 colorectal cancer NA BeFree Detail
<0.001 Geographic Atrophy NA BeFree Detail
<0.001 Nephrotic Syndrome, Minimal Change Toll-like receptor 3 expression and function in childhood idiopathic nephrotic s... BeFree 26123900 Detail
<0.001 Non-Neoplastic Disorder NA BeFree Detail
<0.001 Idiopathic Pulmonary Fibrosis Targeting defective Toll-like receptor-3 function and idiopathic pulmonary fibro... BeFree 25530171 Detail
<0.001 IMMUNE SUPPRESSION NA BeFree Detail
0.120 Macular Degeneration, Age-Related, 1 NA CTD_human Detail
<0.001 PHOTOPAROXYSMAL RESPONSE 1 NA BeFree Detail
<0.001 coronary artery disease TLR3 and TLR4 as potential clinically biomarkers of cardiovascular risk in coron... BeFree 24146036 Detail
<0.001 Chronic kidney disease stage 5 A functional polymorphism in the promoter region of TLR3 is associated with susc... BeFree 25171218 Detail
<0.001 MYD88 Deficiency NA BeFree Detail
0.002 Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified NA GAD Detail
<0.001 Juvenile dermatomyositis Co-localization between autophagic marker, LC3, and TLR4 and TLR3 was observed n... BeFree 25365350 Detail
<0.001 Nasopharyngeal carcinoma NA BeFree Detail
<0.001 Stage II Colorectal Cancer AJCC v7 NA BeFree Detail
<0.001 Inflammatory cardiomyopathy NA BeFree Detail
0.003 Warts NA LHGDN Detail
0.027 Infection NA GAD,LHGDN Detail
<0.001 acute pancreatitis Our article points to genetic polymorphisms in TLR3 and TLR6 as having a plausib... BeFree 25423559 Detail
<0.001 adenocarcinoma NA BeFree Detail
<0.001 anemia NA BeFree Detail
<0.001 arthritis NA BeFree Detail
0.008 rheumatoid arthritis Our results show that rheumatoid arthritis synovial fibroblasts (RASF) express a... BeFree,GAD,LHGDN 24936783 Detail
0.008 rheumatoid arthritis A non-synonymous single-nucleotide polymorphism in the gene encoding Toll-like R... BeFree,GAD,LHGDN 25304972 Detail
0.003 aspergillosis NA BeFree,GAD Detail
0.083 asthma NA BeFree,GAD,RGD Detail
<0.001 Astrocytoma In the present study, pretreatment of U373MG human astrocytoma cells with an iro... BeFree 25591911 Detail
0.002 Autoimmune Diseases NA GAD Detail
<0.001 Bacterial Infections NA BeFree Detail
<0.001 biliary atresia NA BeFree Detail
0.004 Malignant neoplasm of breast β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem... BeFree,GAD 25257174 Detail
0.004 Malignant neoplasm of breast Innate adjuvant receptor Toll-like receptor 3 can promote breast cancer through ... BeFree,GAD 25348355 Detail
<0.001 bronchiolitis NA BeFree Detail
0.002 bronchiolitis obliterans NA GAD Detail
0.002 Bronchiolitis, Viral NA GAD Detail
0.003 cutaneous candidiasis NA BeFree,GAD Detail
<0.001 Malignant tumor of colon NA BeFree Detail
<0.001 Rectal Carcinoma NA BeFree Detail
<0.001 Non-small cell lung carcinoma NA BeFree Detail
0.003 renal cell carcinoma NA LHGDN Detail
Annotation

Annotations

DescrptionSourceLinks
Haplotypes in TLR3 gene might be associated with poor prognosis in OSCC patients. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
However, the C/C genotype for the TLR3 (c.1377 C>T) polymorphism and the Asp/Asp genotype and the As... DisGeNET Detail
NA DisGeNET Detail
These results demonstrate a key role for TLR3-mediated antibody response to CHIKV infection, virus r... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Among the 178 SNPs, 24 were significantly associated with NSCLC prognosis in different genetic model... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The expression of TLR4 and TLR3 closely correlated with the severity of coronary artery disease as r... DisGeNET Detail
The expression of TLR4 and TLR3 closely correlated with the severity of coronary artery disease as r... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
TLR4 and TLR3, two potent inducers of autophagy, were highly increased in IIM, with TLR4 transcripts... DisGeNET Detail
Toll-like receptor 3 (TLR3) and the development of type 1 diabetes mellitus. DisGeNET Detail
Inflammatory unbalance of TLR3 and TLR4 in PCI patients with or without type 2 diabetes mellitus. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Toll-like receptor-3 gene polymorphism in patients with Japanese encephalitis. DisGeNET Detail
Polymorphisms in chemokine receptor 5 and Toll-like receptor 3 genes are risk factors for clinical t... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The results suggest that TLR3 and TIRAP gene variants influence the risk for DHF. DisGeNET Detail
SNPs significantly associated with eye disease included three different polymorphisms TLR8 and hemor... DisGeNET Detail
TLR3 polymorphisms are associated with virologic response to hepatitis C virus (HCV) treatment in HI... DisGeNET Detail
The present study investigated the prevalence of two single-nucleotide polymorphisms (SNPs) in the T... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
TLR3 exhibited an anti-HSV-1 infection capacity via innate immune functions. DisGeNET Detail
The identified IRF3 R285Q amino acid substitution results in impaired IFN responses to HSV-1 infecti... DisGeNET Detail
TLR3 polymorphisms are associated with virologic response to hepatitis C virus (HCV) treatment in HI... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
In men, TLR1, TLR2, and TLR3 were associated with lipid and TLR8 with hypertension treatment. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
These data suggest that obesity is related to TLR-3 impairment and explain, at least in part, the in... DisGeNET Detail
These data show that H1N1 and poly(I:C) can induce αvβ6 integrin-dependent TGFβ activity in epitheli... DisGeNET Detail
Toll-like receptor 3 (TLR3), a receptor for viral double-stranded RNA, is involved in immune cell ac... DisGeNET Detail
A functional polymorphism in the promoter region of TLR3 is associated with susceptibility to end-st... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Genetic polymorphisms in Toll-like receptor 3 gene are associated with the risk of hepatitis B virus... DisGeNET Detail
NA DisGeNET Detail
These data show that H1N1 and poly(I:C) can induce αvβ6 integrin-dependent TGFβ activity in epitheli... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
This study aimed to demonstrate possible associations between genetic polymorphisms in Toll-like rec... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Next, we investigated if dsRNA signaling pathway involvement could be observed in MG-T, as recently ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
For the first time, in the present work, we are convincingly reporting the functional evidence that ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
These data suggest that obesity is related to TLR-3 impairment and explain, at least in part, the in... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
A toll-like receptor 3 single nucleotide polymorphism in Japanese patients with sarcoidosis. DisGeNET Detail
NA DisGeNET Detail
A novel 1,2-benzenediamine derivative FC-99 suppresses TLR3 expression and ameliorates disease sympt... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Next, we investigated if dsRNA signaling pathway involvement could be observed in MG-T, as recently ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The Toll-like receptor 3 (TLR3) gene codes for an endoplasmic receptor of the pattern-recognition re... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Co-localization between autophagic marker, LC3, and TLR4 and TLR3 was observed not only in sIBM but ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
TLR4 and TLR3, two potent inducers of autophagy, were highly increased in IIM, with TLR4 transcripts... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The expression of TLR4 and TLR3 closely correlated with the severity of coronary artery disease as r... DisGeNET Detail
NA DisGeNET Detail
A novel 1,2-benzenediamine derivative FC-99 suppresses TLR3 expression and ameliorates disease sympt... DisGeNET Detail
Co-localization between autophagic marker, LC3, and TLR4 and TLR3 was observed not only in sIBM but ... DisGeNET Detail
PCR array analysis revealed that human mast cells up-regulated several anti-viral genes, including m... DisGeNET Detail
We found that TLR3-ligand polyinosinic-polycytidylic acid and human rhinovirus infection induced a p... DisGeNET Detail
NA DisGeNET Detail
Herpes simplex encephalitis (HSE) in children has previously been linked to defects in type I interf... DisGeNET Detail
We found that TLR3-ligand polyinosinic-polycytidylic acid and human rhinovirus infection induced a p... DisGeNET Detail
NA DisGeNET Detail
A significant downregulation in the gene expression of TLRs 3, 4 and 5 and upregulation of TLR1 was ... DisGeNET Detail
However, the C/C genotype for the TLR3 (c.1377 C>T) polymorphism and the Asp/Asp genotype and the As... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility... DisGeNET Detail
A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility... DisGeNET Detail
The genetic association between a variant in the Toll-like receptor 3 (TLR3) gene (C1234T in mRNA, L... DisGeNET Detail
Genetic association studies have provided evidence concerning the role of a polymorphism in TLR3 (rs... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Toll-like receptor 3 L412F polymorphisms in infants with bronchiolitis and postbronchiolitis wheezin... DisGeNET Detail
Toll-like receptor 3 L412F polymorphism may protect against acute graft rejection in adult patients ... DisGeNET Detail
Toll-like receptor 3 L412F polymorphisms in infants with bronchiolitis and postbronchiolitis wheezin... DisGeNET Detail
The biological significance of TLR3 variant, L412F, in conferring susceptibility to cutaneous candid... DisGeNET Detail
Toll-like receptor 3 L412F polymorphism may protect against acute graft rejection in adult patients ... DisGeNET Detail
We have shown here aberrant biological responses mediated by the TLR3 variant receptor, L412F, which... DisGeNET Detail
Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding c... DisGeNET Detail
The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotype... DisGeNET Detail
Innate adjuvant receptor Toll-like receptor 3 can promote breast cancer through cell surface. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Co-localization between autophagic marker, LC3, and TLR4 and TLR3 was observed not only in sIBM but ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Toll-like receptor-3 is dispensable for the innate microRNA response to West Nile virus (WNV). DisGeNET Detail
NA DisGeNET Detail
TLR3 and TLR4 are known to act as anti-inflammatory and pro-inflammatory factors respectively in mul... DisGeNET Detail
Toll-like receptor 3 (TLR3), a receptor for viral double-stranded RNA, is involved in immune cell ac... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Toll-like receptor 3 expression and function in childhood idiopathic nephrotic syndrome. DisGeNET Detail
NA DisGeNET Detail
Targeting defective Toll-like receptor-3 function and idiopathic pulmonary fibrosis. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
TLR3 and TLR4 as potential clinically biomarkers of cardiovascular risk in coronary artery disease (... DisGeNET Detail
A functional polymorphism in the promoter region of TLR3 is associated with susceptibility to end-st... DisGeNET Detail
NA DisGeNET Detail
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Co-localization between autophagic marker, LC3, and TLR4 and TLR3 was observed not only in sIBM but ... DisGeNET Detail
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Our article points to genetic polymorphisms in TLR3 and TLR6 as having a plausible role in the occur... DisGeNET Detail
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Our results show that rheumatoid arthritis synovial fibroblasts (RASF) express a series of TLRs, inc... DisGeNET Detail
A non-synonymous single-nucleotide polymorphism in the gene encoding Toll-like Receptor 3 (TLR3) is ... DisGeNET Detail
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In the present study, pretreatment of U373MG human astrocytoma cells with an iron chelator desferrio... DisGeNET Detail
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β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotype... DisGeNET Detail
Innate adjuvant receptor Toll-like receptor 3 can promote breast cancer through cell surface. DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386586050 dbSNP
Genome
hg19
Position
chr4:186,990,065-187,009,227
Variant Type
snv
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