Annotation Detail
Information
- Associated Genes
- TLR3
- Associated Variants
-
TLR3 MUTATION
TLR3 MUTATION - Associated Disease
- Herpes Simplex Infections
- Source Database
- DisGeNET
- Description
- The identified IRF3 R285Q amino acid substitution results in impaired IFN responses to HSV-1 infection and particularly impairs signaling through the TLR3-TRIF pathway.
- Pubmed
- 26216125
- Section of the abstract supporting the evidence
- ALL_TEXT_2/3
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 4
- Original source reporting the Gene Disease association
- BeFree,LHGDN
- DisGENET score for the Gene Disease association
- 0.00924888669405859
Drugs