chr2:202098166:> Detail (hg19)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr2:202,098,166-202,226,559 |
| hg38 | chr2:201,233,443-201,361,836 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| 0.003 | squamous cell carcinoma | NA | BeFree,GAD | Detail | |
| 0.002 | Malignant tumor of cervix | Here, we show that Mith decreased Sp1 protein by inducing proteasome-dependent d... | BeFree | 25418289 | Detail |
| 0.120 | Uterine Cervical Neoplasm | NA | CTD_human | Detail | |
| <0.001 | choriocarcinoma | NA | BeFree | Detail | |
| 0.002 | Congenital clubfoot | NA | GAD | Detail | |
| <0.001 | colitis | NA | BeFree | Detail | |
| 0.005 | Colonic Neoplasms | NA | LHGDN | Detail | |
| 0.005 | colorectal carcinoma | The cleavage of Bid activated by caspase-8 might serve as a crosstalk mediator b... | BeFree | 24957706 | Detail |
| 0.120 | Colorectal Neoplasms | NA | BeFree,CTD_human | Detail | |
| 0.003 | Cessation of life | NA | LHGDN | Detail | |
| 0.080 | Dermatitis, Atopic | NA | BeFree,MGD | Detail | |
| 0.120 | contact dermatitis | NA | CTD_human | Detail | |
| 0.003 | diabetes mellitus | NA | BeFree,GAD | Detail | |
| 0.080 | Diabetes Mellitus, Experimental | NA | RGD | Detail | |
| 0.120 | Diabetes Mellitus, Non-Insulin-Dependent | NA | CTD_human | Detail | |
| <0.001 | Eczema | NA | BeFree | Detail | |
| 0.120 | Edema | NA | CTD_human | Detail | |
| <0.001 | encephalitis | NA | BeFree | Detail | |
| 0.080 | Experimental Autoimmune Encephalomyelitis | NA | BeFree,RGD | Detail | |
| 0.002 | Endometrial Neoplasms | NA | GAD | Detail | |
| 0.120 | Esophageal Neoplasms | NA | CTD_human | Detail | |
| <0.001 | Fanconi anemia | NA | BeFree | Detail | |
| <0.001 | fibrosarcoma | NA | BeFree | Detail | |
| 0.004 | glioblastoma | NA | BeFree,LHGDN | Detail | |
| 0.009 | Glioma | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | IgA glomerulonephritis | We investigated whether polymorphisms of apoptotic genes such as B-cell CLL/lymp... | BeFree | 24621205 | Detail |
| 0.003 | Graves Disease | NA | BeFree,LHGDN | Detail | |
| 0.005 | Head and Neck Neoplasms | NA | GAD | Detail | |
| <0.001 | hepatitis | NA | BeFree | Detail | |
| <0.001 | hepatitis A | NA | BeFree | Detail | |
| 0.003 | hepatitis C | NA | LHGDN | Detail | |
| <0.001 | Herpes Simplex Infections | NA | BeFree | Detail | |
| 0.003 | Histiocytosis, Langerhans-Cell | NA | LHGDN | Detail | |
| 0.002 | HIV Infections | Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increase... | BeFree | 25526311 | Detail |
| <0.001 | Huntington disease | NA | BeFree | Detail | |
| 0.006 | Malignant neoplasm of ovary | The aim of the study is to investigate the relevance of rs1056663 and rs2708861 ... | BeFree | 22926736 | Detail |
| 0.002 | ovarian carcinoma | The aim of the study is to investigate the relevance of rs1056663 and rs2708861 ... | BeFree | 22926736 | Detail |
| <0.001 | Immunologic Deficiency Syndromes | NA | BeFree | Detail | |
| 0.002 | male infertility | NA | GAD | Detail | |
| <0.001 | insulinoma | NA | BeFree | Detail | |
| 0.124 | chronic lymphocytic leukemia | After adjustment for multiple testing, we found a strong association between CLL... | BeFree | 19074885 | Detail |
| <0.001 | ischemia | NA | BeFree | Detail | |
| <0.001 | Keloid | NA | BeFree | Detail | |
| 0.003 | leukemia | NA | BeFree,LHGDN | Detail | |
| 0.124 | chronic lymphocytic leukemia | NA | BeFree,GAD,GWASCAT | Detail | |
| <0.001 | Acute lymphocytic leukemia | NA | BeFree | Detail | |
| <0.001 | Leukemia, Lymphocytic, Acute, L1 | NA | BeFree | Detail | |
| <0.001 | Leukemia, Myelocytic, Acute | NA | BeFree | Detail | |
| 0.005 | Myeloid Leukemia, Chronic | NA | GAD | Detail | |
| <0.001 | acute promyelocytic leukemia | NA | BeFree | Detail | |
| <0.001 | Adult T-Cell Lymphoma/Leukemia | NA | BeFree | Detail | |
| <0.001 | Leukoencephalopathy, Progressive Multifocal | NA | BeFree | Detail | |
| 0.001 | Liver neoplasms | NA | BeFree | Detail | |
| 0.003 | Chronic Obstructive Airway Disease | Although expression of mRNA for p21(CIP1/WAF1) and caspase-9 was similar in both... | BeFree,GAD | 24871992 | Detail |
| 0.129 | Lung Neoplasms | NA | BeFree,CTD_human,LHGDN | Detail | |
| <0.001 | Lupus Vulgaris | NA | BeFree | Detail | |
| <0.001 | Lupus Erythematosus, Discoid | NA | BeFree | Detail | |
| <0.001 | Lupus Erythematosus, Systemic | NA | BeFree | Detail | |
| 0.003 | lymphoma | NA | BeFree,LHGDN | Detail | |
| 0.008 | Lymphoma, Non-Hodgkin | NA | BeFree,GAD | Detail | |
| 0.003 | Lymphoproliferative Disorders | NA | LHGDN | Detail | |
| 0.002 | Malignant neoplasm of stomach | NA | BeFree | Detail | |
| 0.002 | Animal Mammary Neoplasms | NA | GAD | Detail | |
| 0.080 | Mammary Neoplasms, Experimental | NA | RGD | Detail | |
| 0.005 | medulloblastoma | NA | BeFree,LHGDN | Detail | |
| 0.128 | melanoma | Random-effects meta-analyses of 81 eligible polymorphisms evaluated in >4 data s... | BeFree,CTD_human,GAD,LHGDN | 25407435 | Detail |
| <0.001 | multiple endocrine neoplasia type 1 | NA | BeFree | Detail | |
| 0.002 | Meningeal Neoplasms | NA | GAD | Detail | |
| 0.006 | meningioma | NA | BeFree,GAD,LHGDN | Detail | |
| 0.006 | multiple myeloma | NA | BeFree,GAD,LHGDN | Detail | |
| 0.003 | multiple sclerosis | NA | BeFree,GAD | Detail | |
| <0.001 | spinal muscular atrophy | NA | BeFree | Detail | |
| <0.001 | Mycoses | NA | BeFree | Detail | |
| <0.001 | mycosis fungoides | NA | BeFree | Detail | |
| <0.001 | myocardial infarction | NA | BeFree | Detail | |
| 0.120 | Myocardial Reperfusion Injury | NA | CTD_human | Detail | |
| 0.002 | narcolepsy | NA | GAD | Detail | |
| <0.001 | Nasal Polyps | NA | BeFree | Detail | |
| 0.005 | Neoplasm Metastasis | NA | BeFree,LHGDN | Detail | |
| 0.002 | Neoplasm Recurrence, Local | NA | GAD | Detail | |
| 0.002 | Pathologic Neovascularization | NA | GAD | Detail | |
| <0.001 | nephroblastoma | NA | BeFree | Detail | |
| <0.001 | Niemann-Pick Diseases | NA | BeFree | Detail | |
| <0.001 | Degenerative polyarthritis | NA | BeFree | Detail | |
| 0.004 | osteosarcoma | NA | BeFree,LHGDN | Detail | |
| 0.002 | ovarian carcinoma | NA | BeFree | Detail | |
| 0.005 | Pancreatic Neoplasm | NA | GAD,LHGDN | Detail | |
| <0.001 | pheochromocytoma | NA | BeFree | Detail | |
| 0.005 | Prostatic Neoplasms | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | Reoviridae Infections | NA | BeFree | Detail | |
| 0.120 | Reperfusion Injury | NA | CTD_human | Detail | |
| 0.003 | retinoblastoma | NA | LHGDN | Detail | |
| <0.001 | Retroviridae Infections | NA | BeFree | Detail | |
| <0.001 | rhabdomyosarcoma | NA | BeFree | Detail | |
| <0.001 | Kaposi sarcoma | NA | BeFree | Detail | |
| <0.001 | Septicemia | NA | BeFree | Detail | |
| <0.001 | Sezary syndrome | NA | BeFree | Detail | |
| <0.001 | silicosis | NA | BeFree | Detail | |
| 0.122 | Skin Neoplasms | NA | CTD_human,GAD | Detail | |
| 0.200 | status epilepticus | NA | CTD_human,RGD | Detail | |
| 0.120 | Stomach Neoplasms | NA | CTD_human | Detail | |
| <0.001 | Cerebrovascular accident | NA | BeFree | Detail | |
| <0.001 | tricuspid valve insufficiency | Immunoblotting of atrial extracts showed that there was enhanced expression of c... | BeFree | 26004742 | Detail |
| <0.001 | tuberculosis | NA | BeFree | Detail | |
| <0.001 | Virus Diseases | NA | BeFree | Detail | |
| <0.001 | B-Cell Lymphomas | NA | BeFree | Detail | |
| <0.001 | Lymphoma, Large-Cell, Follicular | NA | BeFree | Detail | |
| <0.001 | Lymphoma, T-Cell, Cutaneous | NA | BeFree | Detail | |
| <0.001 | severe combined immunodeficiency | NA | BeFree | Detail | |
| 0.003 | Bronchial Hyperreactivity | NA | BeFree,GAD | Detail | |
| 0.002 | Neoplasms, Second Primary | NA | GAD | Detail | |
| <0.001 | Liver failure | NA | BeFree | Detail | |
| 0.004 | Small cell carcinoma of lung | NA | BeFree,LHGDN | Detail | |
| 0.003 | intracranial hypertension | NA | LHGDN | Detail | |
| <0.001 | Cutaneous Melanoma | Random-effects meta-analyses of 81 eligible polymorphisms evaluated in >4 data s... | BeFree | 25407435 | Detail |
| <0.001 | Malignant neoplasm of mouth | Cobalt chloride (CoCl2), a HIF-1α activator, attenuated the IK-induced growth-in... | BeFree | 25105148 | Detail |
| <0.001 | Malignant neoplasm of gallbladder | NA | BeFree | Detail | |
| <0.001 | Liver Failure, Acute | NA | BeFree | Detail | |
| 0.120 | Dermatitis, Allergic Contact | NA | CTD_human | Detail | |
| <0.001 | Tumor Progression | NA | BeFree | Detail | |
| <0.001 | Neuroectodermal Tumors | NA | BeFree | Detail | |
| <0.001 | Ki-1+ Anaplastic Large Cell Lymphoma | NA | BeFree | Detail | |
| <0.001 | germinoma | NA | BeFree | Detail | |
| <0.001 | Lip and oral cavity carcinoma | Cobalt chloride (CoCl2), a HIF-1α activator, attenuated the IK-induced growth-in... | BeFree | 25105148 | Detail |
| <0.001 | Fibrillation | Immunoblotting of atrial extracts showed that there was enhanced expression of c... | BeFree | 26004742 | Detail |
| <0.001 | gallbladder carcinoma | NA | BeFree | Detail | |
| 0.001 | pancreatic carcinoma | NA | BeFree | Detail | |
| 0.002 | Gastrointestinal Stromal Tumors | NA | GAD | Detail | |
| <0.001 | Papillary thyroid carcinoma | NA | BeFree | Detail | |
| 0.014 | Malignant neoplasm of lung | NA | BeFree,GAD | Detail | |
| <0.001 | age related macular degeneration | DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-relate... | BeFree | 25349431 | Detail |
| 0.080 | Sepsis | NA | BeFree,RGD | Detail | |
| <0.001 | Multiple tumors | NA | BeFree | Detail | |
| <0.001 | Crohn's disease of the ileum | NA | BeFree | Detail | |
| <0.001 | Acute viral hepatitis | NA | BeFree | Detail | |
| <0.001 | Disseminated neuroblastoma | NA | BeFree | Detail | |
| <0.001 | Cancer of Head and Neck | Caspase-8 mutations in head and neck cancer confer resistance to death receptor-... | BeFree | 24816188 | Detail |
| <0.001 | Squamous cell carcinoma of esophagus | Apollon knockdown also enhanced cisplatin/docetaxel-induced activation of caspas... | BeFree | 25216531 | Detail |
| <0.001 | Adenocarcinoma Of Esophagus | NA | BeFree | Detail | |
| <0.001 | stage, neuroblastoma | NA | BeFree | Detail | |
| <0.001 | laryngeal squamous cell carcinoma | NA | BeFree | Detail | |
| 0.002 | cervix carcinoma | Here, we show that Mith decreased Sp1 protein by inducing proteasome-dependent d... | BeFree | 25418289 | Detail |
| <0.001 | Superficial ulcer | NA | BeFree | Detail | |
| <0.001 | Carcinoid tumor no ICD-O subtype | NA | BeFree | Detail | |
| <0.001 | malignant fibrous histiocytoma | NA | BeFree | Detail | |
| <0.001 | Breast Cancer, Familial | NA | BeFree | Detail | |
| 0.001 | Malignant neoplasm of pancreas | NA | BeFree | Detail | |
| <0.001 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | NA | BeFree | Detail | |
| <0.001 | lupus erythematosus | NA | BeFree | Detail | |
| 0.006 | multiple myeloma | To examine if five single nucleotide polymorphisms (SNPs) in four caspase genes ... | BeFree | 18381704 | Detail |
| 0.001 | endometrial carcinoma | NA | BeFree | Detail | |
| <0.001 | Recurrent tumor | NA | BeFree | Detail | |
| 0.003 | Neurodegenerative Disorders | NA | BeFree,LHGDN | Detail | |
| <0.001 | Thyroid carcinoma | NA | BeFree | Detail | |
| <0.001 | Ewings sarcoma | Gene modified MSC expressing TRAIL were cocultured with different osteosarcoma, ... | BeFree | 25420617 | Detail |
| 0.001 | Malignant glioma | NA | BeFree | Detail | |
| <0.001 | Osteosarcoma of bone | NA | BeFree | Detail | |
| 0.003 | Carcinogenesis | The signals of carcinogenesis modulate the central control points of the apoptot... | BeFree | 25013758 | Detail |
| 0.003 | Hashimoto Disease | NA | LHGDN | Detail | |
| 0.001 | Epithelial ovarian cancer | NA | BeFree | Detail | |
| <0.001 | Terminal Ileitis | NA | BeFree | Detail | |
| 0.002 | Carcinoma of lung | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of gastrointestinal tract | Further subgroup analysis indicated that CASP8 -652 6N del polymorphism was asso... | BeFree | 25553350 | Detail |
| 0.002 | colon carcinoma | BaxΔ2 promotes apoptosis through caspase-8 activation in microsatellite-unstable... | BeFree | 24842234 | Detail |
| 0.002 | colon carcinoma | A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon... | BeFree | 24934366 | Detail |
| 0.002 | stomach carcinoma | NA | BeFree | Detail | |
| 0.001 | Carcinoma of bladder | NA | BeFree | Detail | |
| <0.001 | Brain Tumor, Primary | NA | BeFree | Detail | |
| <0.001 | Multiple Sclerosis, Primary Progressive | NA | BeFree | Detail | |
| <0.001 | malignant pleural mesothelioma | NA | BeFree | Detail | |
| <0.001 | breast adenocarcinoma | NA | BeFree | Detail | |
| <0.001 | Lupus-like syndrome | NA | BeFree | Detail | |
| 0.120 | Papillomavirus Infections | NA | CTD_human | Detail | |
| <0.001 | West Nile viral infection | NA | BeFree | Detail | |
| <0.001 | Stage 4S neuroblastoma | NA | BeFree | Detail | |
| 0.006 | Malignant neoplasm of ovary | NA | BeFree,GAD | Detail | |
| 0.122 | Squamous cell carcinoma of the head and neck | NA | BeFree,CTD_human | Detail | |
| 0.004 | sarcoma | Sarcoma death was specifically associated with caspase-8 activation starting fro... | BeFree,LHGDN | 25420617 | Detail |
| <0.001 | Primary Effusion Lymphoma | NA | BeFree | Detail | |
| <0.001 | Adenoma of rectum | NA | BeFree | Detail | |
| <0.001 | Hormone refractory prostate cancer | NA | BeFree | Detail | |
| 0.121 | autoimmune lymphoproliferative syndrome | NA | BeFree,CTD_human | Detail | |
| <0.001 | Primary Carcinoma | NA | BeFree | Detail | |
| <0.001 | supratentorial primitive neuroectodermal tumor | NA | BeFree | Detail | |
| <0.001 | Epithelioma | NA | BeFree | Detail | |
| <0.001 | Cardiac fibrosis | Transplantation of caspase 8 shRNA-modified hMSCs could significantly improve in... | BeFree | 25060909 | Detail |
| 0.142 | Mammary Neoplasms | NA | BeFree,CTD_human,GAD,LHGDN | Detail | |
| <0.001 | Hepatocarcinogenesis | NA | BeFree | Detail | |
| <0.001 | Primary Glioblastoma | NA | BeFree | Detail | |
| <0.001 | Tumor Promotion | NA | BeFree | Detail | |
| 0.011 | colorectal cancer | The cleavage of Bid activated by caspase-8 might serve as a crosstalk mediator b... | BeFree,GAD | 24957706 | Detail |
| <0.001 | Geographic Atrophy | Coupled with our observation of increased Caspase-8 expression in the RPE of hum... | BeFree | 25349431 | Detail |
| <0.001 | Tendinopathy | NA | BeFree | Detail | |
| <0.001 | Glioblastoma multiforme | NA | BeFree | Detail | |
| <0.001 | Non-Neoplastic Disorder | NA | BeFree | Detail | |
| <0.001 | Meningioma, benign, no ICD-O subtype | NA | BeFree | Detail | |
| <0.001 | uterine corpus cancer | NA | BeFree | Detail | |
| 0.123 | Precursor Cell Lymphoblastic Leukemia Lymphoma | NA | BeFree,CTD_human,LHGDN | Detail | |
| <0.001 | Promyelocytic leukemia | NA | BeFree | Detail | |
| <0.001 | Nasopharyngeal carcinoma | NA | BeFree | Detail | |
| 0.120 | Cerebral Hemorrhage | NA | CTD_human | Detail | |
| <0.001 | Low grade dysplastic nodule | NA | BeFree | Detail | |
| <0.001 | High grade dysplastic nodule | NA | BeFree | Detail | |
| <0.001 | FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | NA | BeFree | Detail | |
| <0.001 | Triple Negative Breast Neoplasms | Caspase-8 was also activated in TQ-treated TNBC cells, although the mechanism of... | BeFree | 24579801 | Detail |
| 0.003 | Infection | NA | LHGDN | Detail | |
| <0.001 | Tumors in children | NA | BeFree | Detail | |
| <0.001 | Disorder of Achilles tendon | NA | BeFree | Detail | |
| 0.123 | adenocarcinoma | NA | BeFree,CTD_human,GAD | Detail | |
| 0.003 | adenoma | NA | BeFree,LHGDN | Detail | |
| 0.005 | AIDS related complex | NA | LHGDN | Detail | |
| <0.001 | Alzheimer's disease | NA | BeFree | Detail | |
| <0.001 | amyotrophic lateral sclerosis | NA | BeFree | Detail | |
| 0.009 | breast carcinoma | Confirmed BC risk SNPs rs17468277 (CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2),... | BeFree | 22532573 | Detail |
| 0.049 | Malignant neoplasm of breast | Confirmed BC risk SNPs rs17468277 (CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2),... | BeFree | 22532573 | Detail |
| 0.003 | anthracosis | NA | BeFree,GAD | Detail | |
| 0.001 | rheumatoid arthritis | NA | BeFree | Detail | |
| 0.003 | asthma | NA | BeFree,GAD | Detail | |
| <0.001 | bipolar disorder | NA | BeFree | Detail | |
| 0.010 | Malignant neoplasm of urinary bladder | NA | BeFree,GAD | Detail | |
| 0.003 | Bladder Neoplasm | NA | BeFree,LHGDN | Detail | |
| 0.003 | Brain Neoplasms | NA | BeFree,GAD | Detail | |
| <0.001 | Carcinoid Tumor | NA | BeFree | Detail | |
| 0.002 | Malignant tumor of colon | BaxΔ2 promotes apoptosis through caspase-8 activation in microsatellite-unstable... | BeFree | 24842234 | Detail |
| 0.002 | Malignant tumor of colon | A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon... | BeFree | 24934366 | Detail |
| <0.001 | Malignant neoplasm of endometrium | NA | BeFree | Detail | |
| <0.001 | Rectal Carcinoma | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of thyroid | NA | BeFree | Detail | |
| 0.123 | Non-small cell lung carcinoma | Gefitinib induces cytoplasmic translocation of the CDK inhibitor p27 and its bin... | BeFree,CTD_human | 25228008 | Detail |
| <0.001 | Carcinoma, Papillary | NA | BeFree | Detail | |
| 0.006 | renal cell carcinoma | NA | BeFree,GAD,LHGDN | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| NA | DisGeNET | Detail |
| Here, we show that Mith decreased Sp1 protein by inducing proteasome-dependent degradation, thereby ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The cleavage of Bid activated by caspase-8 might serve as a crosstalk mediator between these two pat... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We investigated whether polymorphisms of apoptotic genes such as B-cell CLL/lymphoma 2 (BCL2), BH3-i... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The aim of the study is to investigate the relevance of rs1056663 and rs2708861 HUS1 polymorphisms, ... | DisGeNET | Detail |
| The aim of the study is to investigate the relevance of rs1056663 and rs2708861 HUS1 polymorphisms, ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| After adjustment for multiple testing, we found a strong association between CLL risk and six geneti... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Although expression of mRNA for p21(CIP1/WAF1) and caspase-9 was similar in both groups, p53 and cas... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Random-effects meta-analyses of 81 eligible polymorphisms evaluated in >4 data sets confirmed 20 sin... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Immunoblotting of atrial extracts showed that there was enhanced expression of cytosolic cytochrome ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Random-effects meta-analyses of 81 eligible polymorphisms evaluated in >4 data sets confirmed 20 sin... | DisGeNET | Detail |
| Cobalt chloride (CoCl2), a HIF-1α activator, attenuated the IK-induced growth-inhibiting and apoptos... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Cobalt chloride (CoCl2), a HIF-1α activator, attenuated the IK-induced growth-inhibiting and apoptos... | DisGeNET | Detail |
| Immunoblotting of atrial extracts showed that there was enhanced expression of cytosolic cytochrome ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degenerati... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis a... | DisGeNET | Detail |
| Apollon knockdown also enhanced cisplatin/docetaxel-induced activation of caspase-8 (extrinsic pathw... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Here, we show that Mith decreased Sp1 protein by inducing proteasome-dependent degradation, thereby ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| To examine if five single nucleotide polymorphisms (SNPs) in four caspase genes [CASP3 Ex8-280 C >... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Gene modified MSC expressing TRAIL were cocultured with different osteosarcoma, rhabdomyosarcoma, an... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The signals of carcinogenesis modulate the central control points of the apoptotic pathways, includi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Further subgroup analysis indicated that CASP8 -652 6N del polymorphism was associated with breast c... | DisGeNET | Detail |
| BaxΔ2 promotes apoptosis through caspase-8 activation in microsatellite-unstable colon cancer. | DisGeNET | Detail |
| A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon cancer via caspase-... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Sarcoma death was specifically associated with caspase-8 activation starting from 8 hours of cocultu... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Transplantation of caspase 8 shRNA-modified hMSCs could significantly improve infracted heart functi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The cleavage of Bid activated by caspase-8 might serve as a crosstalk mediator between these two pat... | DisGeNET | Detail |
| Coupled with our observation of increased Caspase-8 expression in the RPE of human eyes with geograp... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Caspase-8 was also activated in TQ-treated TNBC cells, although the mechanism of activation is not c... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Confirmed BC risk SNPs rs17468277 (CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2), rs13281615 (8q24), ... | DisGeNET | Detail |
| Confirmed BC risk SNPs rs17468277 (CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2), rs13281615 (8q24), ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| BaxΔ2 promotes apoptosis through caspase-8 activation in microsatellite-unstable colon cancer. | DisGeNET | Detail |
| A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon cancer via caspase-... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Gefitinib induces cytoplasmic translocation of the CDK inhibitor p27 and its binding to a cleaved in... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- dbSNP
- rs104548 dbSNP
- Genome
- hg19
- Position
- chr2:202,098,166-202,226,559
- Variant Type
- snv
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