chr1:58780791:> Detail (hg38)

Information

Genome

Assembly Position
hg19 chr1:59,246,463-59,249,719 
hg38 chr1:58,780,791-58,784,047

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.001 squamous cell carcinoma NA BeFree Detail
<0.001 Cardiovascular Diseases NA BeFree Detail
0.120 Neoplastic Cell Transformation NA CTD_human Detail
<0.001 cerebral infarction NA BeFree Detail
0.120 brain ischemia NA CTD_human Detail
0.001 Malignant tumor of cervix NA BeFree Detail
<0.001 Congenital chromosomal disease NA BeFree Detail
0.123 Colonic Neoplasms NA CTD_human,LHGDN Detail
0.002 colorectal carcinoma NA BeFree Detail
<0.001 Condylomata Acuminata NA BeFree Detail
0.003 Crohn Disease NA BeFree,GAD Detail
<0.001 cystic fibrosis NA BeFree Detail
0.080 depressive disorder NA RGD Detail
<0.001 dermatitis Here we review the present evidence and the underlying mechanisms of how Jun/AP-... BeFree 26458100 Detail
<0.001 Dermatitis, Atopic Notably, Notch1 is a repressor of activator protein-1 (AP-1), which is upregulat... BeFree 24853951 Detail
0.003 Diabetic Nephropathy NA LHGDN Detail
<0.001 eclampsia NFAT-1, STAT-1 and AP-1 might be the central transcription factors in the pathog... BeFree 24931237 Detail
<0.001 Eczema Notably, Notch1 is a repressor of activator protein-1 (AP-1), which is upregulat... BeFree 24853951 Detail
0.003 Endometrial Neoplasms NA LHGDN Detail
<0.001 Enteritis NA BeFree Detail
<0.001 fibrosarcoma NA BeFree Detail
<0.001 gastritis NA BeFree Detail
<0.001 gastroesophageal reflux disease All results suggested that EGR1, JUN, FOS may play important roles in the develo... BeFree 24706321 Detail
<0.001 glioblastoma NA BeFree Detail
0.003 Glioma NA BeFree,LHGDN Detail
<0.001 glomerulonephritis NA BeFree Detail
<0.001 cardiac arrest NA BeFree Detail
0.120 Heat Stroke NA CTD_human Detail
0.120 Hemangiosarcoma NA CTD_human Detail
0.003 hepatitis NA LHGDN Detail
<0.001 HIV Infections NA BeFree Detail
0.005 Hodgkin Disease NA LHGDN Detail
<0.001 hyperglycemia NA BeFree Detail
0.080 Hypertensive disease NA BeFree,RGD Detail
0.003 pulmonary hypertension NA BeFree,LHGDN Detail
0.120 Intestinal Polyps NA CTD_human Detail
0.080 Kidney Neoplasm NA RGD Detail
<0.001 Polycystic Kidney Diseases NA BeFree Detail
<0.001 leukemia NA BeFree Detail
<0.001 Acute lymphocytic leukemia NA BeFree Detail
<0.001 Leukemia, Myelocytic, Acute NA BeFree Detail
0.003 myeloid leukemia NA BeFree,LHGDN Detail
<0.001 Leukemia, T-Cell NA BeFree Detail
0.002 Adult T-Cell Lymphoma/Leukemia NA BeFree Detail
<0.001 liposarcoma NA BeFree Detail
<0.001 Liver diseases NA BeFree Detail
0.121 Liver neoplasms NA BeFree,CTD_human Detail
<0.001 Lung diseases NA BeFree Detail
0.123 Lung Neoplasms NA CTD_human,LHGDN Detail
0.004 Lupus Erythematosus, Systemic NA BeFree,LHGDN Detail
<0.001 Lyme disease NA BeFree Detail
0.004 lymphoma Furthermore, using a combination of RNA interference and gene expression profili... BeFree,LHGDN 25533033 Detail
0.001 Malignant neoplasm of stomach NA BeFree Detail
0.003 melanoma In summary, there are a variety of mechanisms underlying the induction of c-Jun ... BeFree 24315690 Detail
<0.001 Monoclonal Gammopathy of Undetermined Significance NA BeFree Detail
<0.001 multiple myeloma NA BeFree Detail
0.007 Neoplasm Metastasis Our results suggest that the AP-1/miR-101 feedback loop may prevent the excessiv... BeFree,LHGDN 25260594 Detail
<0.001 neuroblastoma NA BeFree Detail
<0.001 obesity NA BeFree Detail
<0.001 ocular hypertension NA BeFree Detail
<0.001 Degenerative polyarthritis NA BeFree Detail
0.126 osteosarcoma NA BeFree,CTD_human,LHGDN Detail
0.001 ovarian carcinoma NA BeFree Detail
0.005 Pancreatic Neoplasm NA LHGDN Detail
0.120 Peripheral neuropathy NA CTD_human Detail
<0.001 pneumonia NA BeFree Detail
<0.001 polyps NA BeFree Detail
0.011 Prostatic Neoplasms NA LHGDN Detail
<0.001 pseudomyxoma peritonei Concurrent MCL1 and JUN amplification in pseudomyxoma peritonei: a comprehensive... BeFree 24369359 Detail
0.004 psoriasis NA BeFree,LHGDN Detail
<0.001 pulmonary emphysema NA BeFree Detail
0.120 Reperfusion Injury NA CTD_human Detail
<0.001 Respiratory Syncytial Virus Infections In conclusion, the results of the present study indicate that the TLR4 signaling... BeFree 24968899 Detail
<0.001 Rotavirus Infections NA BeFree Detail
0.002 Salmonella infections NA GAD Detail
<0.001 sarcoidosis NA BeFree Detail
<0.001 schizophrenia NA BeFree Detail
<0.001 systemic scleroderma NA BeFree Detail
<0.001 scrub typhus NA BeFree Detail
<0.001 Septicemia NA BeFree Detail
0.120 status epilepticus NA CTD_human Detail
0.125 Stomach Neoplasms NA CTD_human,LHGDN Detail
<0.001 Thyroid Diseases NA BeFree Detail
<0.001 Unipolar Depression Eighty percent of these genes were functionally associated with a key stress res... BeFree 25734512 Detail
<0.001 Vascular Diseases NA BeFree Detail
<0.001 Virus Diseases NA BeFree Detail
<0.001 diffuse large B-cell lymphoma Mechanistically, genome-wide mapping of PRDM11 binding sites coupled with transc... BeFree 25499759 Detail
0.003 Lymphoma, T-Cell, Cutaneous NA BeFree,LHGDN Detail
0.003 Polycystic Kidney, Autosomal Dominant NA BeFree,LHGDN Detail
0.002 Arthritis, Reactive NA GAD Detail
<0.001 Small cell carcinoma of lung NA BeFree Detail
<0.001 Adenocarcinoma of lung (disorder) NA BeFree Detail
<0.001 Tumor Progression In summary, there are a variety of mechanisms underlying the induction of c-Jun ... BeFree 24315690 Detail
<0.001 Liposarcoma, Dedifferentiated NA BeFree Detail
<0.001 Ki-1+ Anaplastic Large Cell Lymphoma Here, we discuss the role of AP-1 in the pathogenesis of ALCL and provide an ove... BeFree 25961698 Detail
0.001 pancreatic carcinoma NA BeFree Detail
<0.001 Medullary carcinoma of thyroid NA BeFree Detail
<0.001 Malignant neoplasm of lung NA BeFree Detail
0.003 Hyperoxia NA LHGDN Detail
<0.001 Sepsis NA BeFree Detail
<0.001 Severe myopia NA BeFree Detail
<0.001 Erythroblastosis NA BeFree Detail
<0.001 Cancer of Head and Neck NA BeFree Detail
<0.001 Condyloma NA BeFree Detail
0.001 cervix carcinoma NA BeFree Detail
<0.001 Restenosis NA BeFree Detail
<0.001 Carcinoid tumor no ICD-O subtype NA BeFree Detail
<0.001 Adenocarcinoma of colon NA BeFree Detail
0.001 Malignant neoplasm of pancreas NA BeFree Detail
<0.001 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
0.002 Malignant neoplasm of prostate NA BeFree Detail
<0.001 Non-alcoholic Fatty Liver Disease NA BeFree Detail
<0.001 Idiopathic crescentic glomerulonephritis NA BeFree Detail
0.120 Mercury Poisoning, Nervous System NA CTD_human Detail
<0.001 Thyroid carcinoma NA BeFree Detail
0.008 Carcinogenesis NA BeFree Detail
0.003 prostate carcinoma NA BeFree Detail
<0.001 Epithelial ovarian cancer NA BeFree Detail
0.004 breast carcinoma NA BeFree Detail
<0.001 Carcinoma of lung NA BeFree Detail
<0.001 Secondary malignant neoplasm of lymph node NA BeFree Detail
0.002 colon carcinoma NA BeFree Detail
0.002 stomach carcinoma NA BeFree Detail
<0.001 Carcinoma of bladder The DEGs encoding activator protein 1 (AP-1), nuclear factor of activated T-cell... BeFree 25050631 Detail
<0.001 Central neuroblastoma NA BeFree Detail
<0.001 Helicobacter pylori infection NA BeFree Detail
<0.001 Invasive breast carcinoma NA BeFree Detail
<0.001 Cerebral Ischemia NA BeFree Detail
<0.001 ovarian neoplasm NA BeFree Detail
0.003 Malignant neoplasm of ovary NA BeFree,GAD Detail
<0.001 Squamous cell carcinoma of the head and neck NA BeFree Detail
<0.001 sarcoma NA BeFree Detail
<0.001 major depressive disorder Eighty percent of these genes were functionally associated with a key stress res... BeFree 25734512 Detail
0.134 Mammary Neoplasms NA BeFree,CTD_human,LHGDN Detail
<0.001 Hepatocarcinogenesis NA BeFree Detail
<0.001 Tumor Angiogenesis NA BeFree Detail
0.001 Tumor Promotion NA BeFree Detail
0.003 colorectal cancer NA BeFree Detail
<0.001 Glucocorticoid Receptor Deficiency NA BeFree Detail
0.080 PULMONARY DISEASE, CHRONIC OBSTRUCTIVE, SEVERE EARLY-ONSET NA MGD Detail
<0.001 Corneal dystrophy, Fuchs' endothelial, 1 NA BeFree Detail
0.080 Emphysema, Hereditary Pulmonary NA MGD Detail
<0.001 Precursor Cell Lymphoblastic Leukemia Lymphoma NA BeFree Detail
0.128 liver carcinoma miR-1285-3p acts as a potential tumor suppressor miRNA via downregulating JUN ex... BeFree,CTD_human,LHGDN 25230788 Detail
0.128 liver carcinoma We showed that CREBH activated by HBx interacted with HBx protein, leading to a ... BeFree,CTD_human,LHGDN 25428452 Detail
0.128 liver carcinoma Mucin1 mediates autocrine transforming growth factor beta signaling through acti... BeFree,CTD_human,LHGDN 25526895 Detail
<0.001 Oropharyngeal Carcinoma Integrated omic analysis of oropharyngeal carcinomas reveals human papillomaviru... BeFree 25271301 Detail
<0.001 Nasopharyngeal carcinoma RNAi-mediated knockdown of the c-jun gene sensitizes radioresistant human nasoph... BeFree 25571870 Detail
0.120 Juvenile arthritis NA CTD_human Detail
<0.001 aortic valve disease 2 NA BeFree Detail
<0.001 intellectual disability NA BeFree Detail
<0.001 Experimental Organism Basal Cell Carcinoma NA BeFree Detail
<0.001 bronchiolitis SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093... BeFree 17703412 Detail
0.005 adenocarcinoma NA LHGDN Detail
<0.001 Alzheimer's disease NA BeFree Detail
<0.001 Anaplasia NA BeFree Detail
<0.001 Anemia, Sickle Cell NA BeFree Detail
0.005 Anoxia NA LHGDN Detail
<0.001 aortic aneurysm NA BeFree Detail
<0.001 aortic valve stenosis NA BeFree Detail
<0.001 arthritis NA BeFree Detail
0.004 rheumatoid arthritis Our findings suggest that overexpression of peroxiredoxin 6 might promote develo... BeFree,LHGDN 26211509 Detail
0.002 asthma NA BeFree Detail
<0.001 Malignant neoplasm of urinary bladder The DEGs encoding activator protein 1 (AP-1), nuclear factor of activated T-cell... BeFree 25050631 Detail
<0.001 Brain Diseases NA BeFree Detail
0.007 Malignant neoplasm of breast NA BeFree,GAD Detail
<0.001 bronchiolitis NA BeFree Detail
0.002 Campylobacter infection NA GAD Detail
<0.001 candidiasis NA BeFree Detail
<0.001 Carcinoid Tumor NA BeFree Detail
0.002 Malignant tumor of colon NA BeFree Detail
<0.001 Malignant neoplasm of skin NA BeFree Detail
<0.001 Malignant neoplasm of thyroid NA BeFree Detail
<0.001 Non-small cell lung carcinoma NA BeFree Detail
<0.001 renal cell carcinoma NA BeFree Detail
Annotation

Annotations

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Here we review the present evidence and the underlying mechanisms of how Jun/AP-1 proteins control s... DisGeNET Detail
Notably, Notch1 is a repressor of activator protein-1 (AP-1), which is upregulated in AD epidermis. DisGeNET Detail
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NFAT-1, STAT-1 and AP-1 might be the central transcription factors in the pathogenesis of pre-eclamp... DisGeNET Detail
Notably, Notch1 is a repressor of activator protein-1 (AP-1), which is upregulated in AD epidermis. DisGeNET Detail
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All results suggested that EGR1, JUN, FOS may play important roles in the development of GERD. DisGeNET Detail
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Furthermore, using a combination of RNA interference and gene expression profiling, we identified Ju... DisGeNET Detail
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In summary, there are a variety of mechanisms underlying the induction of c-Jun protein expression a... DisGeNET Detail
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Our results suggest that the AP-1/miR-101 feedback loop may prevent the excessive activation of meta... DisGeNET Detail
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Concurrent MCL1 and JUN amplification in pseudomyxoma peritonei: a comprehensive genetic profiling a... DisGeNET Detail
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In conclusion, the results of the present study indicate that the TLR4 signaling pathway, in conjunc... DisGeNET Detail
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Eighty percent of these genes were functionally associated with a key stress response signalling cas... DisGeNET Detail
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Mechanistically, genome-wide mapping of PRDM11 binding sites coupled with transcriptome sequencing i... DisGeNET Detail
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In summary, there are a variety of mechanisms underlying the induction of c-Jun protein expression a... DisGeNET Detail
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Here, we discuss the role of AP-1 in the pathogenesis of ALCL and provide an overview of pathologica... DisGeNET Detail
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The DEGs encoding activator protein 1 (AP-1), nuclear factor of activated T-cells (NFAT) proteins, n... DisGeNET Detail
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Eighty percent of these genes were functionally associated with a key stress response signalling cas... DisGeNET Detail
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miR-1285-3p acts as a potential tumor suppressor miRNA via downregulating JUN expression in hepatoce... DisGeNET Detail
We showed that CREBH activated by HBx interacted with HBx protein, leading to a synergistic effect o... DisGeNET Detail
Mucin1 mediates autocrine transforming growth factor beta signaling through activating the c-Jun N-t... DisGeNET Detail
Integrated omic analysis of oropharyngeal carcinomas reveals human papillomavirus (HPV)-dependent re... DisGeNET Detail
RNAi-mediated knockdown of the c-jun gene sensitizes radioresistant human nasopharyngeal carcinoma c... DisGeNET Detail
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SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212... DisGeNET Detail
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Our findings suggest that overexpression of peroxiredoxin 6 might promote development of RA through ... DisGeNET Detail
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The DEGs encoding activator protein 1 (AP-1), nuclear factor of activated T-cells (NFAT) proteins, n... DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs10735810 dbSNP
Genome
hg38
Position
chr1:58,780,791-58,784,047
Variant Type
snv
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