chr5:76011951:> Detail (hg19)

Information

Genome

Assembly Position
hg19 chr5:76,011,951-76,031,595
hg38 chr5:76,716,126-76,735,770 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.003 squamous cell carcinoma NA BeFree,LHGDN Detail
<0.001 carcinosarcoma NA BeFree Detail
0.002 Cardiovascular Diseases NA GAD Detail
<0.001 cerebral infarction NA BeFree Detail
0.080 brain ischemia NA RGD Detail
<0.001 cholestasis NA BeFree Detail
<0.001 choriocarcinoma NA BeFree Detail
<0.001 Congenital chromosomal disease NA BeFree Detail
0.003 Colonic Neoplasms NA BeFree,LHGDN Detail
<0.001 colorectal carcinoma In recent years, the role of long noncoding RNAs (lncRNAs) in cancer is increasi... BeFree 25119598 Detail
0.001 Coronary Arteriosclerosis NA BeFree Detail
0.003 Coronary heart disease NA BeFree,GAD Detail
<0.001 coronary thrombosis NA BeFree Detail
<0.001 Mental Depression NA BeFree Detail
<0.001 depressive disorder NA BeFree Detail
0.002 Dwarfism NA BeFree Detail
0.003 encephalitis NA LHGDN Detail
0.003 endometriosis NA BeFree,LHGDN Detail
0.120 Fatty Liver NA CTD_human Detail
<0.001 gastroesophageal reflux disease NA BeFree Detail
<0.001 glioblastoma NA BeFree Detail
<0.001 Glioma NA BeFree Detail
0.002 Hemorrhage NA GAD Detail
0.120 hepatitis NA CTD_human Detail
<0.001 hepatitis C NA BeFree Detail
<0.001 HIV Infections Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and... BeFree 26283733 Detail
0.083 Hyperalgesia NA LHGDN,RGD Detail
0.080 Hypertensive disease NA RGD Detail
<0.001 hypoglycemia NA BeFree Detail
<0.001 Immunologic Deficiency Syndromes NA BeFree Detail
0.123 Inflammation NA CTD_human,LHGDN Detail
0.003 Inflammatory Bowel Diseases NA LHGDN Detail
<0.001 influenza NA BeFree Detail
<0.001 ischemia NA BeFree Detail
<0.001 Keloid NA BeFree Detail
0.003 Premature Obstetric Labor NA LHGDN Detail
<0.001 leishmaniasis NA BeFree Detail
<0.001 leukemia NA BeFree Detail
<0.001 chronic lymphocytic leukemia NA BeFree Detail
<0.001 Leukemia, Myelocytic, Acute NA BeFree Detail
0.123 liver cirrhosis NA CTD_human,LHGDN Detail
<0.001 Liver neoplasms NA BeFree Detail
<0.001 Lung diseases NA BeFree Detail
<0.001 Chronic Obstructive Airway Disease NA BeFree Detail
<0.001 Lung Neoplasms NA BeFree Detail
<0.001 Lupus Erythematosus, Systemic NA BeFree Detail
0.002 Malignant neoplasm of stomach Thrombin conducts epithelial‑mesenchymal transition via protease‑activated recep... BeFree 25231630 Detail
<0.001 medulloblastoma Coagulation pathway sensors (F3/TF, F2R/PAR-1) are expressed in MB in a subtype-... BeFree 25163932 Detail
0.011 melanoma NA BeFree,LHGDN Detail
<0.001 Mesothelioma The role of PAR1 in mesothelioma progression is just emerging and our observatio... BeFree 25364818 Detail
0.005 myocardial infarction NA BeFree,GAD Detail
<0.001 myocarditis NA BeFree Detail
0.010 Neoplasm Metastasis Collectively, our findings established a functional role for thrombin and its ta... BeFree,LHGDN 26238780 Detail
0.120 Neoplasms, Experimental NA CTD_human Detail
<0.001 Degenerative polyarthritis NA BeFree Detail
<0.001 ovarian carcinoma NA BeFree Detail
0.003 Pancreatic Neoplasm NA BeFree,LHGDN Detail
<0.001 Parkinson disease NA BeFree Detail
<0.001 Peutz-Jeghers syndrome NA BeFree Detail
<0.001 pneumonia NA BeFree Detail
<0.001 Prader-Willi syndrome NA BeFree Detail
0.011 Prostatic Neoplasms NA BeFree,LHGDN Detail
<0.001 pulmonary edema NA BeFree Detail
<0.001 pulmonary emphysema NA BeFree Detail
0.009 pulmonary fibrosis Accumulating evidence shows that protease-activated receptor-1 (PAR-1) plays an ... BeFree,LHGDN 24842054 Detail
<0.001 rhabdomyosarcoma NA BeFree Detail
<0.001 schizophrenia NA BeFree Detail
<0.001 systemic scleroderma NA BeFree Detail
<0.001 Septicemia The cytoprotective effects are protease activated receptor 1 (PAR-1) and endothe... BeFree 25032959 Detail
<0.001 Spinal Cord Diseases NA BeFree Detail
0.120 Stomach Neoplasms NA CTD_human Detail
0.003 Cerebrovascular accident NA BeFree,LHGDN Detail
<0.001 Turner syndrome NA BeFree Detail
<0.001 Virus Diseases NA BeFree Detail
<0.001 Hermanski-Pudlak Syndrome NA BeFree Detail
<0.001 Polyendocrinopathies, Autoimmune NA BeFree Detail
<0.001 Squamous cell carcinoma of lung NA BeFree Detail
0.002 Premature Birth NA GAD Detail
<0.001 Arterial thrombosis NA BeFree Detail
<0.001 lingual-facial-buccal dyskinesia NA BeFree Detail
<0.001 Idiopathic pulmonary hypertension NA BeFree Detail
<0.001 Madelung Deformity NA BeFree Detail
<0.001 Cicatrix, Hypertrophic NA BeFree Detail
0.002 Tumor Progression In recent years, the role of long noncoding RNAs (lncRNAs) in cancer is increasi... BeFree 25119598 Detail
<0.001 cholangiocarcinoma NA BeFree Detail
<0.001 pancreatic carcinoma NA BeFree Detail
<0.001 Fibrosis, Liver NA BeFree Detail
<0.001 Malignant neoplasm of lung This study suggested that the PTEN/PI3K/AKT signaling pathway plays an important... BeFree 25861627 Detail
<0.001 Proliferative vitreoretinopathy The purpose of this study was to identify interacting signaling pathways by whic... BeFree 26247679 Detail
0.004 Sepsis The cytoprotective effects are protease activated receptor 1 (PAR-1) and endothe... BeFree,LHGDN 25032959 Detail
<0.001 carotid artery occlusion NA BeFree Detail
0.003 Leri-Weill dyschondrosteosis NA BeFree Detail
<0.001 Cholestasis of pregnancy This study suggested that overexpression of ERp29 may play a key role in TCA-ind... BeFree 24780196 Detail
0.002 Metastatic melanoma The present finding uncovers a novel role of MDA-9/syntenin as an important TF·F... BeFree 25505176 Detail
<0.001 Squamous cell carcinoma of esophagus Our results indicate that the expression of PAR1 and PAR2 in esophageal squamous... BeFree 25297082 Detail
<0.001 Adenocarcinoma Of Esophagus NA BeFree Detail
<0.001 Vascular Neoplasms Triggering tissue factor (F3/TF) and thrombin receptors (F2R/PAR-1) may influenc... BeFree 25163932 Detail
<0.001 Restenosis NA BeFree Detail
<0.001 Adenocarcinoma of colon Collectively, our findings established a functional role for thrombin and its ta... BeFree 26238780 Detail
<0.001 Helicobacter-associated gastritis Protease-activated receptor 1 suppresses Helicobacter pylori gastritis via the i... BeFree 24866378 Detail
0.120 Platelet mean volume finding NA GWASCAT Detail
<0.001 Adenoma of lung NA BeFree Detail
<0.001 Malignant neoplasm of pancreas NA BeFree Detail
<0.001 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
0.002 Malignant neoplasm of prostate NA BeFree Detail
<0.001 Idiopathic crescentic glomerulonephritis NA BeFree Detail
<0.001 Chronic rejection of renal transplant NA BeFree Detail
<0.001 Langer mesomelic dysplasia syndrome NA BeFree Detail
<0.001 Nephrotic range proteinuria NA BeFree Detail
<0.001 endometrial carcinoma NA BeFree Detail
<0.001 Sleep Apnea, Obstructive NA BeFree Detail
<0.001 Recurrent tumor NA BeFree Detail
0.003 Hepatitis C, Chronic NA BeFree,LHGDN Detail
<0.001 Carcinogenesis NA BeFree Detail
<0.001 schizophrenia While further research into the molecular mechanisms underlying this interaction... BeFree 19352591 Detail
<0.001 Leukemogenesis NA BeFree Detail
0.002 prostate carcinoma NA BeFree Detail
<0.001 Epithelial ovarian cancer NA BeFree Detail
0.003 breast carcinoma NA BeFree Detail
<0.001 Carcinoma of lung This study suggested that the PTEN/PI3K/AKT signaling pathway plays an important... BeFree 25861627 Detail
<0.001 Tardive Dyskinesia NA BeFree Detail
<0.001 Secondary malignant neoplasm of lymph node NA BeFree Detail
<0.001 colon carcinoma Activation of platelet protease-activated receptor-1 induces epithelial-mesenchy... BeFree 25846512 Detail
0.002 stomach carcinoma Thrombin conducts epithelial‑mesenchymal transition via protease‑activated recep... BeFree 25231630 Detail
<0.001 5q-syndrome NA BeFree Detail
<0.001 Malignant neoplasm of kidney NA BeFree Detail
<0.001 Poorly differentiated carcinoma Combined with clinical data, the expression of PAR1 in poorly differentiated (P=... BeFree 25297082 Detail
<0.001 Cholestasis, chronic NA BeFree Detail
<0.001 gastritis h pylori Using chimeric mice, we demonstrated that PAR1-mediated protection against H. py... BeFree 24866378 Detail
<0.001 malignant pleural mesothelioma Altered protease-activated receptor-1 expression and signaling in a malignant pl... BeFree 25364818 Detail
<0.001 Helicobacter pylori infection PAR1 suppression of IRF5 and IL-12/23 secretion by macrophages provides a novel ... BeFree 24866378 Detail
<0.001 Invasive breast carcinoma NA BeFree Detail
<0.001 Rhabdoid Tumor of the Kidney Proteinase-activated receptor 1- and 4-promoted migration of Hep3B hepatocellula... BeFree 25373316 Detail
<0.001 Cholestatic liver disease NA BeFree Detail
<0.001 Cerebral Ischemia NA BeFree Detail
<0.001 Ischemic stroke The cytoprotective effects are protease activated receptor 1 (PAR-1) and endothe... BeFree 25032959 Detail
<0.001 Ischemic stroke Collectively, this study reveals the importance of APC glycosylation in controll... BeFree 26084674 Detail
<0.001 Squamous cell carcinoma of the head and neck NA BeFree Detail
<0.001 attention deficit hyperactivity disorder NA BeFree Detail
<0.001 Precursor B-cell lymphoblastic leukemia NA BeFree Detail
<0.001 Myelodysplastic Syndrome with Isolated del(5q) NA BeFree Detail
<0.001 Partial Trisomy NA BeFree Detail
<0.001 Adenocarcinoma of large intestine NA BeFree Detail
<0.001 Epithelioma NA BeFree Detail
<0.001 renal carcinoma NA BeFree Detail
<0.001 Tumor Angiogenesis NA BeFree Detail
<0.001 colorectal cancer In recent years, the role of long noncoding RNAs (lncRNAs) in cancer is increasi... BeFree 25119598 Detail
0.080 brain edema NA RGD Detail
0.002 Fibrinogen Adverse Event NA GAD Detail
<0.001 Benign Prostatic Hyperplasia NA BeFree Detail
<0.001 Severe Sepsis NA BeFree Detail
<0.001 Idiopathic Pulmonary Fibrosis NA BeFree Detail
<0.001 Chromosome 5, trisomy 5q NA BeFree Detail
<0.001 OVERLAP CONNECTIVE TISSUE DISEASE Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing t... BeFree 25460576 Detail
0.003 Venous thromboembolism NA LHGDN Detail
<0.001 uterine corpus cancer NA BeFree Detail
<0.001 coronary artery disease NA BeFree Detail
0.004 liver carcinoma We have previously shown that PAR1 and PAR4 are able to promote the migration of... BeFree,LHGDN 25373316 Detail
<0.001 Chronic thromboembolic pulmonary hypertension NA BeFree Detail
0.003 Prostatic Hyperplasia NA LHGDN Detail
<0.001 thyroid hormone resistance syndrome NA BeFree Detail
<0.001 Refractory anemia, without ringed sideroblasts, without excess blasts NA BeFree Detail
<0.001 Idiopathic pulmonary arterial hypertension NA BeFree Detail
<0.001 Ischemic Cerebrovascular Accident The cytoprotective effects are protease activated receptor 1 (PAR-1) and endothe... BeFree 25032959 Detail
<0.001 Ischemic Cerebrovascular Accident Collectively, this study reveals the importance of APC glycosylation in controll... BeFree 26084674 Detail
0.003 Infection NA LHGDN Detail
<0.001 Congenital Abnormality NA BeFree Detail
<0.001 Alzheimer's disease NA BeFree Detail
<0.001 Refractory anemias NA BeFree Detail
<0.001 arteriosclerosis NA BeFree Detail
<0.001 rheumatoid arthritis NA BeFree Detail
<0.001 asthma NA BeFree Detail
<0.001 atherosclerosis NA BeFree Detail
<0.001 Autoimmune Diseases NA BeFree Detail
<0.001 Blood Coagulation Disorders NA BeFree Detail
<0.001 Bone Marrow Diseases NA BeFree Detail
<0.001 borderline personality disorder NA BeFree Detail
0.003 Malignant neoplasm of breast NA BeFree Detail
<0.001 Malignant tumor of colon Activation of platelet protease-activated receptor-1 induces epithelial-mesenchy... BeFree 25846512 Detail
<0.001 Malignant neoplasm of endometrium NA BeFree Detail
<0.001 Non-small cell lung carcinoma NA BeFree Detail
<0.001 renal cell carcinoma NA BeFree Detail
Annotation

Annotations

DescrptionSourceLinks
NA DisGeNET Detail
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In recent years, the role of long noncoding RNAs (lncRNAs) in cancer is increasingly focused. ncRuPA... DisGeNET Detail
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Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Converta... DisGeNET Detail
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Thrombin conducts epithelial‑mesenchymal transition via protease‑activated receptor‑1 in human gastr... DisGeNET Detail
Coagulation pathway sensors (F3/TF, F2R/PAR-1) are expressed in MB in a subtype-specific manner, and... DisGeNET Detail
NA DisGeNET Detail
The role of PAR1 in mesothelioma progression is just emerging and our observations can promote furth... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Collectively, our findings established a functional role for thrombin and its targets PAR-1 and fibr... DisGeNET Detail
NA DisGeNET Detail
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Accumulating evidence shows that protease-activated receptor-1 (PAR-1) plays an important role in th... DisGeNET Detail
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The cytoprotective effects are protease activated receptor 1 (PAR-1) and endothelial protein C recep... DisGeNET Detail
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In recent years, the role of long noncoding RNAs (lncRNAs) in cancer is increasingly focused. ncRuPA... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
This study suggested that the PTEN/PI3K/AKT signaling pathway plays an important role in thrombin/PA... DisGeNET Detail
The purpose of this study was to identify interacting signaling pathways by which the activation of ... DisGeNET Detail
The cytoprotective effects are protease activated receptor 1 (PAR-1) and endothelial protein C recep... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
This study suggested that overexpression of ERp29 may play a key role in TCA-induced apoptosis in HT... DisGeNET Detail
The present finding uncovers a novel role of MDA-9/syntenin as an important TF·FVIIa·Xa/PAR-1-regula... DisGeNET Detail
Our results indicate that the expression of PAR1 and PAR2 in esophageal squamous cell carcinoma is i... DisGeNET Detail
NA DisGeNET Detail
Triggering tissue factor (F3/TF) and thrombin receptors (F2R/PAR-1) may influence the vascular tumor... DisGeNET Detail
NA DisGeNET Detail
Collectively, our findings established a functional role for thrombin and its targets PAR-1 and fibr... DisGeNET Detail
Protease-activated receptor 1 suppresses Helicobacter pylori gastritis via the inhibition of macroph... DisGeNET Detail
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While further research into the molecular mechanisms underlying this interaction is needed, our resu... DisGeNET Detail
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NA DisGeNET Detail
This study suggested that the PTEN/PI3K/AKT signaling pathway plays an important role in thrombin/PA... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and c... DisGeNET Detail
Thrombin conducts epithelial‑mesenchymal transition via protease‑activated receptor‑1 in human gastr... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Combined with clinical data, the expression of PAR1 in poorly differentiated (P=0.016) and middle an... DisGeNET Detail
NA DisGeNET Detail
Using chimeric mice, we demonstrated that PAR1-mediated protection against H. pylori gastritis requi... DisGeNET Detail
Altered protease-activated receptor-1 expression and signaling in a malignant pleural mesothelioma c... DisGeNET Detail
PAR1 suppression of IRF5 and IL-12/23 secretion by macrophages provides a novel mechanism by which t... DisGeNET Detail
NA DisGeNET Detail
Proteinase-activated receptor 1- and 4-promoted migration of Hep3B hepatocellular carcinoma cells de... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The cytoprotective effects are protease activated receptor 1 (PAR-1) and endothelial protein C recep... DisGeNET Detail
Collectively, this study reveals the importance of APC glycosylation in controlling the efficacy of ... DisGeNET Detail
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In recent years, the role of long noncoding RNAs (lncRNAs) in cancer is increasingly focused. ncRuPA... DisGeNET Detail
NA DisGeNET Detail
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NA DisGeNET Detail
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Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
We have previously shown that PAR1 and PAR4 are able to promote the migration of hepatocellular carc... DisGeNET Detail
NA DisGeNET Detail
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NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The cytoprotective effects are protease activated receptor 1 (PAR-1) and endothelial protein C recep... DisGeNET Detail
Collectively, this study reveals the importance of APC glycosylation in controlling the efficacy of ... DisGeNET Detail
NA DisGeNET Detail
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Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and c... DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386602276 dbSNP
Genome
hg19
Position
chr5:76,011,951-76,031,595
Variant Type
snv
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