chr10:45374176:> Detail (hg38)

Information

Genome

Assembly Position
hg19 chr10:45,869,624-45,941,567 
hg38 chr10:45,374,176-45,446,119

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.002 Cardiovascular Diseases NA BeFree Detail
0.003 Carotid Artery Diseases NA BeFree,GAD Detail
0.080 brain ischemia NA RGD Detail
0.002 Cerebrovascular Disorders NA GAD Detail
<0.001 Bronchitis, Chronic NA BeFree Detail
0.120 colitis NA CTD_human Detail
0.126 Colonic Neoplasms NA BeFree,CTD_human,LHGDN Detail
0.123 Colonic Polyps NA BeFree,CTD_human,GAD Detail
<0.001 colorectal carcinoma NA BeFree Detail
0.003 Colorectal Neoplasms NA BeFree,LHGDN Detail
0.001 Coronary Arteriosclerosis NA BeFree Detail
0.002 Coronary heart disease NA BeFree Detail
0.120 Drug Eruptions NA CTD_human Detail
<0.001 dermatomyositis NA BeFree Detail
0.003 diabetes mellitus NA BeFree,GAD Detail
0.003 Diabetes Mellitus, Non-Insulin-Dependent NA BeFree,GAD Detail
<0.001 Experimental Autoimmune Encephalomyelitis NA BeFree Detail
<0.001 Enterocolitis NA BeFree Detail
0.003 Esophageal Neoplasms NA LHGDN Detail
0.006 glioblastoma NA BeFree,GAD,LHGDN Detail
0.002 Glioma NA GAD Detail
<0.001 glomerulonephritis NA BeFree Detail
<0.001 hepatitis B NA BeFree Detail
<0.001 Hodgkin Disease NA BeFree Detail
<0.001 Huntington disease NA BeFree Detail
0.120 Hyperalgesia NA CTD_human Detail
<0.001 Hypercholesterolemia, Familial NA BeFree Detail
<0.001 Hyperlipidemia NA BeFree Detail
0.002 Immediate hypersensitivity NA GAD Detail
0.081 Hypertensive disease NA BeFree,RGD Detail
0.080 Hypertension, Portal NA RGD Detail
0.200 pulmonary hypertension NA CTD_human,RGD Detail
0.080 Inflammation NA RGD Detail
0.003 Inflammatory Bowel Diseases NA BeFree,LHGDN Detail
<0.001 ischemia NA BeFree Detail
0.002 Kidney Diseases NA GAD Detail
0.003 Kidney Failure, Chronic NA BeFree,GAD Detail
0.003 Kidney Neoplasm NA LHGDN Detail
<0.001 leukemia NA BeFree Detail
<0.001 Leukemia, Myelocytic, Acute NA BeFree Detail
0.121 Myeloid Leukemia, Chronic Low leukotriene B4 receptor 1 leads to ALOX5 downregulation at diagnosis of chro... BeFree,CTD_human 25193960 Detail
<0.001 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma NA BeFree Detail
<0.001 acute promyelocytic leukemia NA BeFree Detail
<0.001 liver cirrhosis NA BeFree Detail
<0.001 Liver neoplasms NA BeFree Detail
0.002 Chronic Obstructive Airway Disease NA GAD Detail
<0.001 lymphoma NA BeFree Detail
<0.001 multiple myeloma NA BeFree Detail
0.120 Multiple Organ Failure NA CTD_human Detail
0.008 myocardial infarction NA BeFree,GAD Detail
0.080 Myocardial Reperfusion Injury NA RGD Detail
0.003 myositis NA LHGDN Detail
0.002 narcolepsy NA GAD Detail
0.120 Neoplasm Invasiveness NA CTD_human Detail
0.003 Ischemic Cerebrovascular Accident To investigate whether single nucleotide polymorphisms (SNPs) of eicosanoid bios... BeFree 21816595 Detail
0.003 Ischemic stroke To investigate whether single nucleotide polymorphisms (SNPs) of eicosanoid bios... BeFree 21816595 Detail
0.121 Neoplasm Metastasis NA BeFree,CTD_human Detail
0.080 nephrotic syndrome NA BeFree,RGD Detail
<0.001 obesity NA BeFree Detail
<0.001 Degenerative polyarthritis Our results showed that increased basal COL10A1 expression in OA hMSCs was signi... BeFree 25091567 Detail
<0.001 osteosarcoma NA BeFree Detail
<0.001 ovarian carcinoma NA BeFree Detail
0.080 Pain NA RGD Detail
0.003 Pancreatic Neoplasm NA BeFree,LHGDN Detail
<0.001 Periodontitis, Juvenile NA BeFree Detail
<0.001 Pleural effusion disorder NA BeFree Detail
0.080 pleurisy NA RGD Detail
<0.001 pneumonia NA BeFree Detail
<0.001 polyps NA BeFree Detail
0.005 Prostatic Neoplasms NA LHGDN Detail
0.080 pulmonary edema NA RGD Detail
<0.001 kidney failure NA BeFree Detail
0.200 Reperfusion Injury NA CTD_human,RGD Detail
0.002 Respiratory Syncytial Virus Infections NA GAD Detail
<0.001 Retinal Diseases NA BeFree Detail
0.002 rhinitis NA GAD Detail
<0.001 systemic scleroderma NA BeFree Detail
<0.001 Septicemia NA BeFree Detail
0.002 sinusitis NA GAD Detail
0.120 Stomach Neoplasms NA CTD_human Detail
0.010 Cerebrovascular accident Previous studies have implicated that two at-risk haplotypes (HapA and HapB) of ... BeFree,GAD 24198186 Detail
0.002 Subarachnoid Hemorrhage NA GAD Detail
0.003 Testicular Neoplasms NA LHGDN Detail
0.003 tuberculosis NA BeFree,LHGDN Detail
<0.001 Tuberculosis, Meningeal NA BeFree Detail
0.003 Tuberculosis, Pulmonary NA BeFree,GAD Detail
0.123 urticaria NA BeFree,CTD_human,LHGDN Detail
0.002 Vascular Diseases NA GAD Detail
0.002 Bronchial Hyperreactivity NA GAD Detail
<0.001 polymyositis NA BeFree Detail
0.002 Intracranial Hemorrhages NA GAD Detail
<0.001 Idiopathic pulmonary hypertension NA BeFree Detail
<0.001 Malignant neoplasm of mouth NA BeFree Detail
<0.001 Aortic Aneurysm, Abdominal 5-Lipoxygenase pathway in experimental abdominal aortic aneurysms. BeFree 25324573 Detail
<0.001 Tumor Progression NA BeFree Detail
<0.001 Lung Diseases, Interstitial NA BeFree Detail
0.080 Radiation Pneumonitis NA RGD Detail
0.003 Adenomatous Polyps NA BeFree,LHGDN Detail
<0.001 Lip and oral cavity carcinoma NA BeFree Detail
<0.001 Adult type dermatomyositis NA BeFree Detail
<0.001 Memory impairment Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunct... BeFree 25122659 Detail
0.001 pancreatic carcinoma Inhibition of 5-lipoxygenase triggers apoptosis in pancreatic cancer cells. BeFree 25483364 Detail
<0.001 Papillary thyroid carcinoma NA BeFree Detail
<0.001 Fibrosis, Liver The 5-lipoxygenase (5-LOX) pathway has been associated with a variety of inflamm... BeFree 25483364 Detail
0.002 Malignant neoplasm of lung NA GAD Detail
0.080 Hyperoxia NA RGD Detail
<0.001 Sepsis NA BeFree Detail
<0.001 Childhood asthma NA BeFree Detail
<0.001 Adenocarcinoma of pancreas In the present study, 5-LOX was found to be overexpressed not only in pancreatic... BeFree 25483364 Detail
<0.001 Xanthoma NA BeFree Detail
<0.001 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse NA BeFree Detail
<0.001 Aortic aneurysm without mention of rupture NOS NA BeFree Detail
0.002 Malignant neoplasm of pancreas Inhibition of 5-lipoxygenase triggers apoptosis in pancreatic cancer cells. BeFree 25483364 Detail
0.004 Malignant neoplasm of prostate Inhibition of 5-lipoxygenase selectively triggers disruption of c-Myc signaling ... BeFree,GAD 25540201 Detail
0.120 Endotoxemia NA CTD_human Detail
<0.001 Non-alcoholic Fatty Liver Disease NA BeFree Detail
<0.001 Sleep Apnea, Obstructive NA BeFree Detail
<0.001 Neurodegenerative Disorders NA BeFree Detail
<0.001 Carotid Atherosclerosis NA BeFree Detail
<0.001 Osteosarcoma of bone NA BeFree Detail
0.002 Carcinogenesis NA BeFree Detail
0.002 prostate carcinoma Inhibition of 5-lipoxygenase selectively triggers disruption of c-Myc signaling ... BeFree 25540201 Detail
0.002 prostate carcinoma Wedelolactone, a plant coumestan, was shown to act as anti-cancer agent for brea... BeFree 25934092 Detail
<0.001 Epithelial ovarian cancer NA BeFree Detail
0.001 breast carcinoma NA BeFree Detail
<0.001 Malignant neoplasm of gastrointestinal tract NA BeFree Detail
<0.001 Secondary malignant neoplasm of lymph node These results suggest that the level of 5-LOX expression was increased in pancre... BeFree 25483364 Detail
0.001 colon carcinoma NA BeFree Detail
0.120 Infarction, Middle Cerebral Artery NA CTD_human Detail
<0.001 Idiopathic Inflammatory Myopathies NA BeFree Detail
0.002 Multiple Sclerosis, Relapsing-Remitting NA GAD Detail
<0.001 Adenomatous polyp of colon NA BeFree Detail
0.003 ovarian neoplasm NA LHGDN Detail
0.003 Ischemic stroke NA BeFree Detail
0.003 Acute coronary syndrome NA BeFree,GAD Detail
<0.001 Polyp of large intestine NA BeFree Detail
<0.001 Tauopathies Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunct... BeFree 25122659 Detail
<0.001 Malignant neoplasm of ovary NA BeFree Detail
0.002 Blood pressure finding NA GAD Detail
0.002 Systemic arterial pressure NA GAD Detail
<0.001 Inflammatory disorder The 5-lipoxygenase (5-LOX) pathway has been associated with a variety of inflamm... BeFree 25483364 Detail
<0.001 Precursor B-cell lymphoblastic leukemia NA BeFree Detail
<0.001 Adenoma of large intestine NA BeFree Detail
0.003 Asthma, Aspirin-Induced NA BeFree,GAD Detail
0.003 Mammary Neoplasms NA BeFree,LHGDN Detail
<0.001 Cancer Cell Growth NA BeFree Detail
<0.001 Xenograft Model NA BeFree Detail
0.008 colorectal cancer NA BeFree,GAD Detail
<0.001 Renal Insufficiency NA BeFree Detail
<0.001 Glioblastoma multiforme NA BeFree Detail
<0.001 Cirrhosis NA BeFree Detail
<0.001 Benign Prostatic Hyperplasia NA BeFree Detail
0.120 ASTHMA, DIMINISHED RESPONSE TO ANTILEUKOTRIENE TREATMENT IN NA CLINVAR Detail
<0.001 Glucocorticoid Receptor Deficiency NA BeFree Detail
<0.001 Aural atresia, congenital NA BeFree Detail
0.120 Atherosclerosis, susceptibility to NA CLINVAR Detail
0.004 coronary artery disease NA BeFree,GAD Detail
<0.001 Moderate persistent asthma NA BeFree Detail
0.001 liver carcinoma NA BeFree Detail
<0.001 Chronic kidney disease stage 5 NA BeFree Detail
0.080 Acute kidney injury NA RGD Detail
<0.001 Promyelocytic leukemia NA BeFree Detail
0.002 Cerebral Hemorrhage NA GAD Detail
<0.001 Idiopathic pulmonary arterial hypertension NA BeFree Detail
0.003 Ischemic Cerebrovascular Accident NA BeFree Detail
<0.001 aortic valve disease 2 NA BeFree Detail
0.003 Infection NA LHGDN Detail
0.002 Hyperhomocystinemia NA GAD Detail
0.003 adenocarcinoma NA LHGDN Detail
0.121 adenoma NA BeFree,CTD_human Detail
0.010 Alzheimer's disease Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunct... BeFree,GAD,LHGDN 25122659 Detail
<0.001 amyloidosis NA BeFree Detail
<0.001 amyotrophic lateral sclerosis NA BeFree Detail
0.001 Aneurysm Inhibition of 5-LO by pharmacological or genetic approaches attenuates aneurysm ... BeFree 25324573 Detail
0.001 aortic aneurysm Targeted interruption of the 5-LO pathway is a potential treatment strategy in A... BeFree 25324573 Detail
<0.001 aortic valve stenosis NA BeFree Detail
0.005 arteriosclerosis The eicosanoid genes ALOX5, ALOX5AP and LTA4H have been implicated in atheroscle... BeFree 25721704 Detail
<0.001 arthritis Our results provide the evidence that the administration of 5-LOX inhibitors is ... BeFree 25229347 Detail
0.121 rheumatoid arthritis The lipoxygenase isoform of 5-lipoxygenase (5-LOX) is reported to be overexpress... BeFree,CTD_human 25229347 Detail
0.171 asthma The 5-lipoxygenase (5-LOX) pathway has been associated with a variety of inflamm... BeFree,CTD_human,GAD,LHGDN 25483364 Detail
0.171 asthma The 5-lipoxygenase product 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is ... BeFree,CTD_human,GAD,LHGDN 26032638 Detail
<0.001 Asthma, Exercise-Induced NA BeFree Detail
<0.001 Astrocytoma NA BeFree Detail
0.139 atherosclerosis The eicosanoid genes ALOX5, ALOX5AP and LTA4H have been implicated in atheroscle... BeFree,CTD_human,GAD,LHGDN 25721704 Detail
0.002 Malignant neoplasm of urinary bladder NA GAD Detail
0.003 Bladder Neoplasm NA LHGDN Detail
<0.001 Blast Phase On treatment initiation, ALOX5 levels increased in all patients except those who... BeFree 25193960 Detail
<0.001 Brain Neoplasms NA BeFree Detail
0.001 Malignant neoplasm of breast NA BeFree Detail
0.002 Bronchiolitis, Viral NA GAD Detail
0.001 Malignant tumor of colon NA BeFree Detail
<0.001 Rectal Carcinoma NA BeFree Detail
Annotation

Annotations

DescrptionSourceLinks
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Low leukotriene B4 receptor 1 leads to ALOX5 downregulation at diagnosis of chronic myeloid leukemia... DisGeNET Detail
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To investigate whether single nucleotide polymorphisms (SNPs) of eicosanoid biosynthesis genes are a... DisGeNET Detail
To investigate whether single nucleotide polymorphisms (SNPs) of eicosanoid biosynthesis genes are a... DisGeNET Detail
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Our results showed that increased basal COL10A1 expression in OA hMSCs was significantly suppressed ... DisGeNET Detail
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Previous studies have implicated that two at-risk haplotypes (HapA and HapB) of gene-encoding 5-lipo... DisGeNET Detail
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5-Lipoxygenase pathway in experimental abdominal aortic aneurysms. DisGeNET Detail
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Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in... DisGeNET Detail
Inhibition of 5-lipoxygenase triggers apoptosis in pancreatic cancer cells. DisGeNET Detail
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The 5-lipoxygenase (5-LOX) pathway has been associated with a variety of inflammatory diseases inclu... DisGeNET Detail
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In the present study, 5-LOX was found to be overexpressed not only in pancreatic cancer cell lines b... DisGeNET Detail
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Inhibition of 5-lipoxygenase triggers apoptosis in pancreatic cancer cells. DisGeNET Detail
Inhibition of 5-lipoxygenase selectively triggers disruption of c-Myc signaling in prostate cancer c... DisGeNET Detail
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Inhibition of 5-lipoxygenase selectively triggers disruption of c-Myc signaling in prostate cancer c... DisGeNET Detail
Wedelolactone, a plant coumestan, was shown to act as anti-cancer agent for breast and prostate carc... DisGeNET Detail
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These results suggest that the level of 5-LOX expression was increased in pancreatic cancer tissues ... DisGeNET Detail
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Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in... DisGeNET Detail
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The 5-lipoxygenase (5-LOX) pathway has been associated with a variety of inflammatory diseases inclu... DisGeNET Detail
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Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in... DisGeNET Detail
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Inhibition of 5-LO by pharmacological or genetic approaches attenuates aneurysm formation and preven... DisGeNET Detail
Targeted interruption of the 5-LO pathway is a potential treatment strategy in AAA. DisGeNET Detail
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The eicosanoid genes ALOX5, ALOX5AP and LTA4H have been implicated in atherosclerosis. DisGeNET Detail
Our results provide the evidence that the administration of 5-LOX inhibitors is able to ameliorate T... DisGeNET Detail
The lipoxygenase isoform of 5-lipoxygenase (5-LOX) is reported to be overexpressed in human rheumato... DisGeNET Detail
The 5-lipoxygenase (5-LOX) pathway has been associated with a variety of inflammatory diseases inclu... DisGeNET Detail
The 5-lipoxygenase product 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is the most powerful hu... DisGeNET Detail
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The eicosanoid genes ALOX5, ALOX5AP and LTA4H have been implicated in atherosclerosis. DisGeNET Detail
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On treatment initiation, ALOX5 levels increased in all patients except those who were destined to pr... DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386592567 dbSNP
Genome
hg38
Position
chr10:45,374,176-45,446,119
Variant Type
snv
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