chr17:40351194:> Detail (hg19)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr17:40,351,194-40,440,651 |
| hg38 | chr17:42,199,176-42,288,633 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| <0.001 | Malignant tumor of cervix | NA | BeFree | Detail | |
| <0.001 | colitis | NA | BeFree | Detail | |
| <0.001 | colorectal carcinoma | NA | BeFree | Detail | |
| <0.001 | Crohn Disease | NA | BeFree | Detail | |
| <0.001 | dermatitis | NA | BeFree | Detail | |
| <0.001 | Dermatitis, Atopic | NA | BeFree | Detail | |
| <0.001 | Diabetes | NA | BeFree | Detail | |
| <0.001 | diabetes mellitus | NA | BeFree | Detail | |
| 0.080 | Diabetes Mellitus, Experimental | NA | RGD | Detail | |
| <0.001 | Diabetes Mellitus, Insulin-Dependent | NA | BeFree | Detail | |
| <0.001 | Diabetic Nephropathy | NA | BeFree | Detail | |
| <0.001 | Eczema | NA | BeFree | Detail | |
| <0.001 | Enteritis | NA | BeFree | Detail | |
| <0.001 | Failure to Thrive | NA | BeFree | Detail | |
| 0.002 | glioblastoma | Association between STAT5 polymorphisms and glioblastoma risk in Han Chinese pop... | BeFree | 24878107 | Detail |
| <0.001 | Hamartoma Syndrome, Multiple | NA | BeFree | Detail | |
| 0.003 | Head and Neck Neoplasms | NA | LHGDN | Detail | |
| <0.001 | Chronic myeloproliferative disorder | Phospho-STAT5 expression pattern with the MPL W515L mutation is similar to that ... | BeFree | 18479730 | Detail |
| 0.002 | HIV Infections | NA | BeFree | Detail | |
| <0.001 | Hodgkin Disease | NA | BeFree | Detail | |
| <0.001 | Hypergammaglobulinemia | In conclusion, STAT-5 is activated constitutively in PB leucocytes in patients w... | BeFree | 25736842 | Detail |
| <0.001 | hyperprolactinemia | NA | BeFree | Detail | |
| <0.001 | Immunologic Deficiency Syndromes | NA | BeFree | Detail | |
| <0.001 | Immune System Diseases | NA | BeFree | Detail | |
| <0.001 | insulinoma | NA | BeFree | Detail | |
| 0.009 | leukemia | We conclude that combining kinase inhibition with STAT5 inhibition represents a ... | BeFree,LHGDN | 24813920 | Detail |
| <0.001 | chronic lymphocytic leukemia | NA | BeFree | Detail | |
| <0.001 | Acute Erythroblastic Leukemia | NA | BeFree | Detail | |
| 0.001 | Acute lymphocytic leukemia | NA | BeFree | Detail | |
| 0.006 | Leukemia, Myelocytic, Acute | NF-κB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukem... | BeFree | 25092144 | Detail |
| 0.006 | Leukemia, Myelocytic, Acute | Signal transducer and activator of transcription 5 (STAT5) is activated in CD34(... | BeFree | 26059451 | Detail |
| 0.003 | myeloid leukemia | NA | BeFree,GAD | Detail | |
| 0.007 | Myeloid Leukemia, Chronic | Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and ma... | BeFree | 24598853 | Detail |
| 0.007 | Myeloid Leukemia, Chronic | Sustained inhibition of STAT5, but not JAK2, is essential for TKI-induced cell d... | BeFree | 24813920 | Detail |
| 0.007 | Myeloid Leukemia, Chronic | STAT5 is a BCR-ABL substrate and persistently activated by tyrosine phosphorylat... | BeFree | 25885255 | Detail |
| 0.007 | Myeloid Leukemia, Chronic | We found that activation of PPARγ by the glitazones decreases expression of STAT... | BeFree | 26331539 | Detail |
| 0.125 | acute promyelocytic leukemia | NA | BeFree,LHGDN,ORPHANET | Detail | |
| <0.001 | Leukemia, T-Cell | NA | BeFree | Detail | |
| <0.001 | Adult T-Cell Lymphoma/Leukemia | NA | BeFree | Detail | |
| <0.001 | Leukemia, T-Cell, Chronic | These results for the first time provide a portrait of the mutational landscape ... | BeFree | 24825865 | Detail |
| <0.001 | leukopenia | NA | BeFree | Detail | |
| <0.001 | lipoma | We previously identified a target gene, LPP/miR-28 (LIM domain containing prefer... | BeFree | 24681953 | Detail |
| <0.001 | Liver neoplasms | NA | BeFree | Detail | |
| <0.001 | Lung diseases | NA | BeFree | Detail | |
| <0.001 | Lung Neoplasms | NA | BeFree | Detail | |
| 0.002 | lymphoma | Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK ce... | BeFree | 25586472 | Detail |
| <0.001 | Lymphoma, Follicular | NA | BeFree | Detail | |
| <0.001 | Lymphoma, Non-Hodgkin | NA | BeFree | Detail | |
| <0.001 | Waldenstrom Macroglobulinemia | NA | BeFree | Detail | |
| <0.001 | mastocytosis | Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and ma... | BeFree | 24598853 | Detail |
| 0.003 | melanoma | NA | LHGDN | Detail | |
| <0.001 | Monosomy | NA | BeFree | Detail | |
| <0.001 | multiple myeloma | NA | BeFree | Detail | |
| <0.001 | spinal muscular atrophy | NA | BeFree | Detail | |
| 0.002 | myelofibrosis | NA | BeFree | Detail | |
| <0.001 | Myeloproliferative disease | NA | BeFree | Detail | |
| 0.002 | Neoplasm Metastasis | NA | BeFree | Detail | |
| <0.001 | neurilemmoma | NA | BeFree | Detail | |
| <0.001 | neuroblastoma | NA | BeFree | Detail | |
| <0.001 | neutropenia | NA | BeFree | Detail | |
| <0.001 | obesity | NA | BeFree | Detail | |
| <0.001 | ovarian carcinoma | Pyrosequencing analyses confirmed that SGI-110 caused both global (LINE1) and ge... | BeFree | 25316809 | Detail |
| <0.001 | Pituitary Diseases | NA | BeFree | Detail | |
| 0.002 | polycythemia vera | NA | BeFree | Detail | |
| <0.001 | prolactinoma | NA | BeFree | Detail | |
| 0.005 | Prostatic Neoplasms | NA | LHGDN | Detail | |
| 0.080 | Reperfusion Injury | NA | RGD | Detail | |
| <0.001 | rheumatic heart disease | We observed that STAT3 CG and GG genotypes were significantly associated with RH... | BeFree | 24797343 | Detail |
| <0.001 | Sezary syndrome | NA | BeFree | Detail | |
| <0.001 | post-traumatic stress disorder | NA | BeFree | Detail | |
| 0.001 | Thrombocythemia, Essential | NA | BeFree | Detail | |
| <0.001 | tuberculosis | NA | BeFree | Detail | |
| <0.001 | urticaria pigmentosa | Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and ma... | BeFree | 24598853 | Detail |
| <0.001 | Vascular Diseases | NA | BeFree | Detail | |
| <0.001 | B-Cell Lymphomas | NA | BeFree | Detail | |
| <0.001 | Lymphoma, Large-Cell, Follicular | NA | BeFree | Detail | |
| 0.120 | T-Cell Lymphoma | STAT5B N642H is particularly frequent in all forms of γδ-T-cell lymphomas. | BeFree,CTD_human | 25586472 | Detail |
| 0.124 | Lymphoma, T-Cell, Cutaneous | Constitutive activation of STAT5 and STAT3 was observed in early and late stages... | BeFree,CTD_human,LHGDN | 25485578 | Detail |
| <0.001 | acute leukemia | NA | BeFree | Detail | |
| <0.001 | Primary Sj�gren's syndrome | STAT-5 is activated constitutively in T cells, B cells and monocytes from patien... | BeFree | 25736842 | Detail |
| <0.001 | Adenocarcinoma of lung (disorder) | NA | BeFree | Detail | |
| <0.001 | Idiopathic pulmonary hypertension | Finally, we found enhanced platelet-derived growth factor (PDGF) and signal tran... | BeFree | 25216946 | Detail |
| <0.001 | Idiopathic pulmonary hypertension | Studies of SMCs and endothelial cell (EC) lines derived from vessels isolated fr... | BeFree | 25470773 | Detail |
| <0.001 | Familial erythrocytosis | NA | BeFree | Detail | |
| <0.001 | Malnutrition | NA | BeFree | Detail | |
| <0.001 | Aortic Aneurysm, Abdominal | Transcriptional (ChIP-Chip) Analysis of ELF1, ETS2, RUNX1 and STAT5 in Human Abd... | BeFree | 25993293 | Detail |
| 0.001 | Tumor Progression | In conclusion, NPM and p-JAK2/STAT5B may have important roles in tumor progressi... | BeFree | 25907517 | Detail |
| <0.001 | Malignant neoplasm of salivary gland | p-STAT5 might be useful as a detection marker of MASC in the differential diagno... | BeFree | 26252941 | Detail |
| 0.001 | Mastocytosis, Systemic | The present article provides an overview of our current knowledge about the crit... | BeFree | 24598853 | Detail |
| <0.001 | pancreatic carcinoma | NA | BeFree | Detail | |
| <0.001 | secondary myelofibrosis | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of lung | The obtained results highlight the importance of the genes STAT5B and COX-2 in l... | BeFree | 25137041 | Detail |
| <0.001 | Somatotropin deficiency | NA | BeFree | Detail | |
| <0.001 | Laron syndrome | NA | BeFree | Detail | |
| <0.001 | Carcinoma breast stage IV | NA | BeFree | Detail | |
| <0.001 | Ovarian epithelial cancer recurrent | NA | BeFree | Detail | |
| <0.001 | Cancer of Head and Neck | NA | BeFree | Detail | |
| <0.001 | Acute Undifferentiated Leukemia | NA | BeFree | Detail | |
| <0.001 | cervix carcinoma | NA | BeFree | Detail | |
| <0.001 | Congenital neutropenia | NA | BeFree | Detail | |
| <0.001 | Chondrodysplasia | NA | BeFree | Detail | |
| <0.001 | chronic eosinophilic leukemia | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of pancreas | NA | BeFree | Detail | |
| 0.003 | Malignant neoplasm of prostate | NA | BeFree | Detail | |
| <0.001 | Hematopoietic Neoplasms | NA | BeFree | Detail | |
| 0.002 | Hematologic Neoplasms | The identification and characterization of a STAT5 gene signature in hematologic... | BeFree | 25524945 | Detail |
| 0.080 | Endotoxemia | NA | RGD | Detail | |
| 0.004 | Carcinogenesis | Together, these observations suggest that STAT5 and AKT are key drivers of oncog... | BeFree | 24598853 | Detail |
| 0.004 | Leukemogenesis | These results reveal a leukemic pathway involving FAK/Tiam1/Rac1/PAK1 and demons... | BeFree | 25456130 | Detail |
| 0.004 | Leukemogenesis | Specific miRNA silencing or the inhibition of Stat5-associated pathways might co... | BeFree | 25730818 | Detail |
| <0.001 | Lymphoid neoplasm | NA | BeFree | Detail | |
| 0.002 | Primary myelofibrosis | Hemopoietic progenitor cells (HPC) from myeloproliferative neoplasms (MPN) such ... | BeFree | 23445613 | Detail |
| <0.001 | Chronic myeloproliferative disorder | STAT5 activation is critical for the transformation mediated by myeloproliferati... | BeFree | 20028972 | Detail |
| 0.002 | myelofibrosis | Hemopoietic progenitor cells (HPC) from myeloproliferative neoplasms (MPN) such ... | BeFree | 23445613 | Detail |
| 0.002 | Primary myelofibrosis | JAK2(V617F) failed to induce polycythemia in recipients after deletion of Stat5a... | BeFree | 22234689 | Detail |
| <0.001 | Myeloproliferative disease | STAT5 activation is critical for the transformation mediated by myeloproliferati... | BeFree | 20028972 | Detail |
| 0.003 | prostate carcinoma | NA | BeFree | Detail | |
| 0.002 | myelofibrosis | JAK2(V617F) failed to induce polycythemia in recipients after deletion of Stat5a... | BeFree | 22234689 | Detail |
| <0.001 | Epithelial ovarian cancer | NA | BeFree | Detail | |
| <0.001 | Acute Erythroblastic Leukemia | Specifically, five derivative compounds of G6 having structural similarity to th... | BeFree | 20667821 | Detail |
| 0.002 | polycythemia vera | Activated STAT1 and STAT5 transcription factors in extramedullary hematopoietic ... | BeFree | 20013324 | Detail |
| 0.007 | Myeloid Leukemia, Chronic | In the present study, we used mice with a conditional null mutation in the Stat5... | BeFree | 22234689 | Detail |
| 0.003 | Malignant neoplasm of prostate | Future work should focus on determining the molecular mechanisms other than V617... | BeFree | 20966544 | Detail |
| 0.002 | polycythemia vera | In the present study, we used mice with a conditional null mutation in the Stat5... | BeFree | 22234689 | Detail |
| 0.008 | breast carcinoma | SOCS2 (one of three SNPs) and all STAT3, STAT5A, and STAT5B SNPs significantly i... | BeFree | 25104439 | Detail |
| 0.008 | breast carcinoma | STAT3 genetic variant, alone and in combination with STAT5b polymorphism, contri... | BeFree | 25487443 | Detail |
| 0.008 | breast carcinoma | STAT3 and STAT5b polymorphism contributes to breast cancer risk and clinical out... | BeFree | 25973100 | Detail |
| <0.001 | Carcinoma of lung | The obtained results highlight the importance of the genes STAT5B and COX-2 in l... | BeFree | 25137041 | Detail |
| <0.001 | colon carcinoma | The results of this study, for the first time, suggest functional roles of MUC13... | BeFree | 24097071 | Detail |
| <0.001 | Central neuroblastoma | NA | BeFree | Detail | |
| <0.001 | Intraepithelial Neoplasia | NA | BeFree | Detail | |
| <0.001 | Growth failure | NA | BeFree | Detail | |
| <0.001 | ovarian neoplasm | NA | BeFree | Detail | |
| <0.001 | Acute coronary syndrome | Modulation of STAT3 and STAT5 activity rectifies the imbalance of Th17 and Treg ... | BeFree | 25572535 | Detail |
| <0.001 | Malignant neoplasm of ovary | Pyrosequencing analyses confirmed that SGI-110 caused both global (LINE1) and ge... | BeFree | 25316809 | Detail |
| <0.001 | Squamous cell carcinoma of the head and neck | NA | BeFree | Detail | |
| <0.001 | Mammary Carcinoma, Human | NA | BeFree | Detail | |
| <0.001 | sarcoma | NA | BeFree | Detail | |
| <0.001 | Precursor B-cell lymphoblastic leukemia | NA | BeFree | Detail | |
| <0.001 | Chronic myeloproliferative disorder | NA | BeFree | Detail | |
| <0.001 | Adenocarcinoma of large intestine | NA | BeFree | Detail | |
| <0.001 | Classical Hodgkin's Lymphoma | NA | BeFree | Detail | |
| <0.001 | Undifferentiated leukemia | NA | BeFree | Detail | |
| 0.010 | Mammary Neoplasms | NA | BeFree,LHGDN | Detail | |
| 0.121 | Leukemia, Large Granular Lymphocytic | NA | BeFree,CTD_human | Detail | |
| <0.001 | colorectal cancer | NA | BeFree | Detail | |
| <0.001 | severe congenital neutropenia | NA | BeFree | Detail | |
| <0.001 | T-cell large granular lymphocyte leukemia | NA | BeFree | Detail | |
| <0.001 | Philadelphia chromosome-positive acute lymphoblastic leukemia | NA | BeFree | Detail | |
| 0.003 | Precursor Cell Lymphoblastic Leukemia Lymphoma | NA | BeFree,GAD | Detail | |
| 0.001 | liver carcinoma | NA | BeFree | Detail | |
| <0.001 | T-cell prolymphocytic leukemia | These results for the first time provide a portrait of the mutational landscape ... | BeFree | 24825865 | Detail |
| 0.120 | T-Lymphocytopenia | NA | CTD_human | Detail | |
| <0.001 | Nasopharyngeal carcinoma | NA | BeFree | Detail | |
| <0.001 | myeloid neoplasm | Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulati... | BeFree | 24681953 | Detail |
| <0.001 | Pulmonary arterial hypertension | Finally, we found enhanced platelet-derived growth factor (PDGF) and signal tran... | BeFree | 25216946 | Detail |
| <0.001 | CHROMOSOME 8p11 MYELOPROLIFERATIVE SYNDROME | NA | BeFree | Detail | |
| <0.001 | Idiopathic pulmonary arterial hypertension | Studies of SMCs and endothelial cell (EC) lines derived from vessels isolated fr... | BeFree | 25470773 | Detail |
| <0.001 | Lipomatosis, Multiple | We previously identified a target gene, LPP/miR-28 (LIM domain containing prefer... | BeFree | 24681953 | Detail |
| <0.001 | Isolated somatotropin deficiency | NA | BeFree | Detail | |
| <0.001 | Pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia | Finally, we found enhanced platelet-derived growth factor (PDGF) and signal tran... | BeFree | 25216946 | Detail |
| <0.001 | immunodeficiency 13 | NA | BeFree | Detail | |
| 0.080 | Acute-Phase Reaction | NA | RGD | Detail | |
| <0.001 | adenocarcinoma | NA | BeFree | Detail | |
| 0.002 | Primary myelofibrosis | NA | BeFree | Detail | |
| 0.083 | Anoxia | NA | LHGDN,RGD | Detail | |
| <0.001 | rheumatoid arthritis | NA | BeFree | Detail | |
| <0.001 | Astrocytoma | In conclusion, NPM and p-JAK2/STAT5B may have important roles in tumor progressi... | BeFree | 25907517 | Detail |
| <0.001 | Autoimmune Diseases | NA | BeFree | Detail | |
| <0.001 | Brain Neoplasms | NA | BeFree | Detail | |
| 0.011 | Malignant neoplasm of breast | SOCS2 (one of three SNPs) and all STAT3, STAT5A, and STAT5B SNPs significantly i... | BeFree,GAD | 25104439 | Detail |
| 0.011 | Malignant neoplasm of breast | STAT3 genetic variant, alone and in combination with STAT5b polymorphism, contri... | BeFree,GAD | 25487443 | Detail |
| 0.011 | Malignant neoplasm of breast | STAT3 and STAT5b polymorphism contributes to breast cancer risk and clinical out... | BeFree,GAD | 25973100 | Detail |
| <0.001 | Malignant tumor of colon | The results of this study, for the first time, suggest functional roles of MUC13... | BeFree | 24097071 | Detail |
| <0.001 | Non-small cell lung carcinoma | Expression of STAT5, COX-2 and PIAS3 in correlation with NSCLC histhopathologica... | BeFree | 25137041 | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association between STAT5 polymorphisms and glioblastoma risk in Han Chinese population. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Phospho-STAT5 expression pattern with the MPL W515L mutation is similar to that seen in chronic myel... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In conclusion, STAT-5 is activated constitutively in PB leucocytes in patients with pSS, and basal S... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We conclude that combining kinase inhibition with STAT5 inhibition represents a promising therapeuti... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NF-κB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia. | DisGeNET | Detail |
| Signal transducer and activator of transcription 5 (STAT5) is activated in CD34(+)/CD38(-) acute mye... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible... | DisGeNET | Detail |
| Sustained inhibition of STAT5, but not JAK2, is essential for TKI-induced cell death in chronic myel... | DisGeNET | Detail |
| STAT5 is a BCR-ABL substrate and persistently activated by tyrosine phosphorylation in CML cells. | DisGeNET | Detail |
| We found that activation of PPARγ by the glitazones decreases expression of STAT5 and its downstream... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| These results for the first time provide a portrait of the mutational landscape of T-PLL and implica... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We previously identified a target gene, LPP/miR-28 (LIM domain containing preferred translocation pa... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Pyrosequencing analyses confirmed that SGI-110 caused both global (LINE1) and gene-specific hypometh... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We observed that STAT3 CG and GG genotypes were significantly associated with RHD (p=0.030 and p=0.0... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| STAT5B N642H is particularly frequent in all forms of γδ-T-cell lymphomas. | DisGeNET | Detail |
| Constitutive activation of STAT5 and STAT3 was observed in early and late stages of CTCL, respective... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| STAT-5 is activated constitutively in T cells, B cells and monocytes from patients with primary Sjög... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Finally, we found enhanced platelet-derived growth factor (PDGF) and signal transducer and activator... | DisGeNET | Detail |
| Studies of SMCs and endothelial cell (EC) lines derived from vessels isolated from lungs of male and... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Transcriptional (ChIP-Chip) Analysis of ELF1, ETS2, RUNX1 and STAT5 in Human Abdominal Aortic Aneury... | DisGeNET | Detail |
| In conclusion, NPM and p-JAK2/STAT5B may have important roles in tumor progression, and STAT5B is an... | DisGeNET | Detail |
| p-STAT5 might be useful as a detection marker of MASC in the differential diagnosis of salivary glan... | DisGeNET | Detail |
| The present article provides an overview of our current knowledge about the critical role of AKT and... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The obtained results highlight the importance of the genes STAT5B and COX-2 in lung cancer progressi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The identification and characterization of a STAT5 gene signature in hematologic malignancies. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Together, these observations suggest that STAT5 and AKT are key drivers of oncogenesis in drug-resis... | DisGeNET | Detail |
| These results reveal a leukemic pathway involving FAK/Tiam1/Rac1/PAK1 and demonstrate an essential r... | DisGeNET | Detail |
| Specific miRNA silencing or the inhibition of Stat5-associated pathways might contribute to preventi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Hemopoietic progenitor cells (HPC) from myeloproliferative neoplasms (MPN) such as myelofibrosis com... | DisGeNET | Detail |
| STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associat... | DisGeNET | Detail |
| Hemopoietic progenitor cells (HPC) from myeloproliferative neoplasms (MPN) such as myelofibrosis com... | DisGeNET | Detail |
| JAK2(V617F) failed to induce polycythemia in recipients after deletion of Stat5a/b, although the los... | DisGeNET | Detail |
| STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associat... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| JAK2(V617F) failed to induce polycythemia in recipients after deletion of Stat5a/b, although the los... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Specifically, five derivative compounds of G6 having structural similarity to the original lead comp... | DisGeNET | Detail |
| Activated STAT1 and STAT5 transcription factors in extramedullary hematopoietic tissue in a polycyth... | DisGeNET | Detail |
| In the present study, we used mice with a conditional null mutation in the Stat5a/b gene locus to de... | DisGeNET | Detail |
| Future work should focus on determining the molecular mechanisms other than V617F mutation of Jak2 r... | DisGeNET | Detail |
| In the present study, we used mice with a conditional null mutation in the Stat5a/b gene locus to de... | DisGeNET | Detail |
| SOCS2 (one of three SNPs) and all STAT3, STAT5A, and STAT5B SNPs significantly interacted with use o... | DisGeNET | Detail |
| STAT3 genetic variant, alone and in combination with STAT5b polymorphism, contributes to breast canc... | DisGeNET | Detail |
| STAT3 and STAT5b polymorphism contributes to breast cancer risk and clinical outcomes. | DisGeNET | Detail |
| The obtained results highlight the importance of the genes STAT5B and COX-2 in lung cancer progressi... | DisGeNET | Detail |
| The results of this study, for the first time, suggest functional roles of MUC13 in colon cancer pro... | DisGeNET | Detail |
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| Modulation of STAT3 and STAT5 activity rectifies the imbalance of Th17 and Treg cells in patients wi... | DisGeNET | Detail |
| Pyrosequencing analyses confirmed that SGI-110 caused both global (LINE1) and gene-specific hypometh... | DisGeNET | Detail |
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| These results for the first time provide a portrait of the mutational landscape of T-PLL and implica... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
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| Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation. | DisGeNET | Detail |
| Finally, we found enhanced platelet-derived growth factor (PDGF) and signal transducer and activator... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Studies of SMCs and endothelial cell (EC) lines derived from vessels isolated from lungs of male and... | DisGeNET | Detail |
| We previously identified a target gene, LPP/miR-28 (LIM domain containing preferred translocation pa... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Finally, we found enhanced platelet-derived growth factor (PDGF) and signal transducer and activator... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
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| In conclusion, NPM and p-JAK2/STAT5B may have important roles in tumor progression, and STAT5B is an... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
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| SOCS2 (one of three SNPs) and all STAT3, STAT5A, and STAT5B SNPs significantly interacted with use o... | DisGeNET | Detail |
| STAT3 genetic variant, alone and in combination with STAT5b polymorphism, contributes to breast canc... | DisGeNET | Detail |
| STAT3 and STAT5b polymorphism contributes to breast cancer risk and clinical outcomes. | DisGeNET | Detail |
| The results of this study, for the first time, suggest functional roles of MUC13 in colon cancer pro... | DisGeNET | Detail |
| Expression of STAT5, COX-2 and PIAS3 in correlation with NSCLC histhopathological features. | DisGeNET | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- dbSNP
- rs386626619 dbSNP
- Genome
- hg19
- Position
- chr17:40,351,194-40,440,651
- Variant Type
- snv
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