Annotation Detail
Information
- Associated Genes
- STAT5B
- Associated Variants
-
STAT5B MUTATION
STAT5B MUTATION - Associated Disease
- Myeloid Leukemia, Chronic
- Source Database
- DisGeNET
- Description
- We found that activation of PPARγ by the glitazones decreases expression of STAT5 and its downstream targets HIF2α and CITED2, which are key guardians of the quiescence and stemness of CML LSCs.
- Pubmed
- 26331539
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 11
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00732893054616819
Drugs