chr10:43572516:> Detail (hg19) (RET)

Information

Genome

Assembly Position
hg19 chr10:43,572,516-43,625,799
hg38 chr10:43,077,068-43,130,351 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.080 brain ischemia NA RGD Detail
<0.001 Developmental Disabilities NA BeFree Detail
0.001 Congenital chromosomal disease NA BeFree Detail
0.080 Congenital clubfoot NA MGD Detail
<0.001 colorectal carcinoma NA BeFree Detail
0.120 Colorectal Neoplasms NA CTD_human Detail
<0.001 Constipation NA BeFree Detail
<0.001 Cyst NA BeFree Detail
0.080 Deafness NA RGD Detail
0.003 Down syndrome NA BeFree,GAD Detail
0.002 Endocrine System Diseases NA BeFree Detail
0.002 Endocrine Gland Neoplasms NA BeFree Detail
<0.001 Esophageal Achalasia NA BeFree Detail
<0.001 ganglioneuroma NA BeFree Detail
<0.001 Gastrointestinal Diseases NA BeFree Detail
<0.001 glomus tumor NA BeFree Detail
0.002 goiter NA BeFree Detail
0.001 nodular goiter Levels of miR-146a and miR-146b expression in PTC tissues were higher compared t... BeFree 25524940 Detail
0.012 Head and Neck Neoplasms NA GAD Detail
0.012 Von Hippel-Lindau syndrome NA BeFree,GAD Detail
0.001 Hodgkin Disease NA BeFree Detail
<0.001 HSAN Type IV NA BeFree Detail
0.001 Huntington disease NA BeFree Detail
0.002 hydronephrosis NA GAD Detail
0.003 hypercalcemia NA BeFree,LHGDN Detail
0.005 hyperparathyroidism NA BeFree Detail
0.008 Hyperplasia NA GAD,LHGDN Detail
0.002 Hypertensive disease NA GAD Detail
<0.001 hypothyroidism NA BeFree Detail
0.003 Inflammation NA LHGDN Detail
<0.001 insulinoma NA BeFree Detail
0.002 Kidney Diseases NA GAD Detail
<0.001 Kidney Failure, Chronic NA BeFree Detail
<0.001 leukemia NA BeFree Detail
0.002 Leukemia, Myelocytic, Acute NA BeFree Detail
<0.001 Myeloid Leukemia, Chronic NA BeFree Detail
<0.001 Leukemia, Myelomonocytic, Chronic NA BeFree Detail
<0.001 liposarcoma Accordingly, knockdown of SPIN1 or MAZ results in reduced levels of GDNF and act... BeFree 25749382 Detail
0.002 Chronic Obstructive Airway Disease NA GAD Detail
<0.001 Lung Neoplasms The results suggest that the RET fusion functions as a driver for the developmen... BeFree 25064355 Detail
<0.001 Lupus Erythematosus, Systemic NA BeFree Detail
0.005 Lymphatic Metastasis NA GAD Detail
<0.001 Malignant neoplasm of stomach NA BeFree Detail
<0.001 medulloblastoma NA BeFree Detail
<0.001 megacolon NA BeFree Detail
<0.001 Melanosis NA BeFree Detail
0.002 multiple endocrine neoplasia type 1 NA BeFree Detail
<0.001 Myeloproliferative disease NA BeFree Detail
0.019 Neoplasm Metastasis These results indicate that TERT promoter mutations are associated with the deve... BeFree,GAD,LHGDN 25583906 Detail
0.019 Neoplasm Metastasis However, the prevalence, clinical characteristics, and outcome of patients with ... BeFree,GAD,LHGDN 25773866 Detail
0.007 Neoplasm Recurrence, Local NA GAD Detail
0.305 multiple endocrine neoplasia Mutation of the RET proto-oncogene is known to be responsible for development of... BeFree,CLINVAR,CTD_human,GAD,LHGDN 24805091 Detail
0.002 Neoplasms, Multiple Primary NA GAD Detail
0.001 Neoplasms, Radiation-Induced NA BeFree Detail
0.003 nephroblastoma NA BeFree,LHGDN Detail
<0.001 nervous system disorder NA BeFree Detail
<0.001 neurilemmoma NA BeFree Detail
0.012 neuroblastoma We developed a RET mini-gene reporter system, and showed that MCS+9.7 enhanced H... BeFree,LHGDN 24794774 Detail
0.003 neurofibromatosis 1 HNPGs in patients with rearranged during transfection (RET), neurofibromatosis t... BeFree 23913591 Detail
<0.001 Nodule NA BeFree Detail
0.004 Thyroid Nodule Elevated thyroid nodule risks were associated with the minor alleles of RET S836... BeFree 19138047 Detail
0.008 Pancreatic Neoplasm NA BeFree,GAD,LHGDN Detail
0.032 paraganglioma NA BeFree,GAD,LHGDN Detail
<0.001 Extra-Adrenal Paraganglioma NA BeFree Detail
<0.001 Parathyroid Diseases NA BeFree Detail
0.002 Parathyroid Neoplasms NA BeFree Detail
<0.001 Parkinson disease NA BeFree Detail
<0.001 Peripheral neuropathy NA BeFree Detail
0.001 pituitary adenoma NA BeFree Detail
0.002 Pituitary Diseases NA BeFree Detail
<0.001 Pituitary Neoplasms NA BeFree Detail
<0.001 Adenomatous Polyposis Coli We report a FAP-associated CMVPTC tumor with atypically aggressive features harb... BeFree 24702198 Detail
<0.001 Precancerous Conditions NA BeFree Detail
0.002 Prostatic Neoplasms NA GAD Detail
0.002 schizophrenia NA GAD Detail
<0.001 seminoma NA BeFree Detail
<0.001 Skin Neoplasms NA BeFree Detail
<0.001 Skin nodule NA BeFree Detail
0.120 status epilepticus NA CTD_human Detail
<0.001 struma ovarii NA BeFree Detail
<0.001 substance dependence NA BeFree Detail
0.004 Thyroid Diseases NA BeFree,GAD Detail
0.258 Thyroid Neoplasm NA BeFree,CTD_human,GAD,LHGDN Detail
0.004 Thyroid Nodule A molecular profile including BRAF and RAS mutations as well as RET/PTC rearrang... BeFree 25333496 Detail
0.002 thyroiditis NA BeFree Detail
0.002 Tobacco use disorder NA GAD Detail
<0.001 Trisomy NA BeFree Detail
0.003 Urogenital Abnormalities NA BeFree,GAD Detail
0.012 Vesico-Ureteral Reflux NA BeFree,GAD,LHGDN Detail
0.002 Vitamin A Deficiency NA GAD Detail
<0.001 Werner syndrome NA BeFree Detail
<0.001 Hallopeau-Siemens Disease NA BeFree Detail
<0.001 Pleural Effusion, Malignant Clinical and prognostic implications of RET rearrangements in metastatic lung ad... BeFree 25773866 Detail
<0.001 severe combined immunodeficiency NA BeFree Detail
0.002 Neoplasms, Second Primary NA GAD Detail
0.004 Aganglionosis, Colonic In further subgroup analysis, the RET-CSGALNACT2-RASGEF1A genomic region was obs... BeFree 25310821 Detail
0.004 Aganglionosis, Colonic Cumulative effects of the RET and EDNRB genes contribute to long-segment and tot... BeFree 25638620 Detail
<0.001 benign neoplasm NA BeFree Detail
0.001 Small cell carcinoma of lung RET mutation and expression in small-cell lung cancer. BeFree 25122427 Detail
0.002 Thyroid Gland Follicular Adenoma NA BeFree Detail
<0.001 Atrophic condition of skin NA BeFree Detail
0.006 Adenocarcinoma of lung (disorder) This study constructed and analyzed transgenic mice expressing KIF5B-RET, the pr... BeFree 25064355 Detail
0.006 Adenocarcinoma of lung (disorder) Further analysis of RET mRNA expression in SCLC revealed wide variability in bot... BeFree 25122427 Detail
0.006 Adenocarcinoma of lung (disorder) RET-rearranged lung adenocarcinomas with lymphangitic spread, psammoma bodies, a... BeFree 25436805 Detail
0.006 Adenocarcinoma of lung (disorder) We analyzed 214 mutations across 26 lung cancer-associated genes and three fusio... BeFree 25760072 Detail
0.006 Adenocarcinoma of lung (disorder) However, the prevalence, clinical characteristics, and outcome of patients with ... BeFree 25773866 Detail
0.006 Adenocarcinoma of lung (disorder) This report delivers a comprehensive genetic alteration profile of lung adenocar... BeFree 25855381 Detail
0.006 Adenocarcinoma of lung (disorder) Among these, RET fusion transcripts are detectable in about 1-2% of lung adenoca... BeFree 25884512 Detail
0.006 Adenocarcinoma of lung (disorder) Decoding Tumor Phenotypes for ALK, ROS1, and RET Fusions in Lung Adenocarcinoma ... BeFree 26469915 Detail
<0.001 Malignant neoplasm of mouth Persephin: A potential key component in human oral cancer progression through th... BeFree 24375483 Detail
<0.001 Malignant neoplasm of brain The majority of the observed loci do not overlap with coding sequences; however,... BeFree 25644941 Detail
<0.001 Malignant tumor of parathyroid gland NA BeFree Detail
0.002 Urea Cycle Disorders, Inborn NA GAD Detail
0.003 Tumor Progression Combining several agents would seem to be more promising, in particular agents t... BeFree 25627652 Detail
<0.001 Adenocarcinoma, Oxyphilic NA BeFree Detail
0.003 follicular adenoma NA BeFree Detail
<0.001 Adenoma, Trabecular NA BeFree Detail
0.002 Anaplastic carcinoma NA BeFree Detail
0.001 Undifferentiated carcinoma NA BeFree Detail
<0.001 Germ cell tumor Next generation sequencing analysis of platinum refractory advanced germ cell tu... BeFree 25085632 Detail
<0.001 Liposarcoma, Myxoid NA BeFree Detail
<0.001 alveolar soft part sarcoma NA BeFree Detail
0.005 Follicular thyroid carcinoma NA BeFree Detail
0.002 Papillary and follicular adenocarcinoma NA GAD Detail
0.158 Medullary carcinoma RET/PTC mutations are often discovered both in papillary and in medullary carcin... BeFree,CTD_human,GAD,LHGDN 25465739 Detail
0.002 Neuroendocrine Tumors Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mut... BeFree 25435367 Detail
<0.001 Lip and oral cavity carcinoma Persephin: A potential key component in human oral cancer progression through th... BeFree 24375483 Detail
0.006 Hyperparathyroidism, Primary The multiple endocrine neoplasia type 2A (MEN 2A) syndrome, comprising medullary... BeFree,LHGDN 24684035 Detail
0.006 Hyperparathyroidism, Primary MEN2A represents more than 50% of all MEN2 cases, having a regular pattern with ... BeFree,LHGDN 24969991 Detail
<0.001 Melanosis coli NA BeFree Detail
<0.001 Taste bitter NA BeFree Detail
<0.001 Megacolon, not Hirschsprung's NA BeFree Detail
0.002 pancreatic carcinoma NA BeFree Detail
0.004 Anaplastic thyroid carcinoma Genetically engineered models of papillary and undifferentiated (anaplastic) thy... BeFree 24295207 Detail
<0.001 color blindness NA BeFree Detail
0.010 Malignant neoplasm of lung Oncogenic fusion of the RET (rearranged during transfection) gene was recently i... BeFree,GAD 25064355 Detail
0.010 Malignant neoplasm of lung The decreased MARVELD1 level in lung cancer reduces NMD efficiency through dimin... BeFree,GAD 25520033 Detail
0.010 Malignant neoplasm of lung Oncogenic RET tyrosine kinase gene fusions and activating mutations have recentl... BeFree,GAD 25546157 Detail
0.002 age related macular degeneration NA GAD Detail
0.080 Parkinsonian Disorders NA RGD Detail
<0.001 Multiple tumors The mice expressed the KIF5B-RET fusion gene specifically in lung alveolar epith... BeFree 25064355 Detail
<0.001 parathyroid adenoma NA BeFree Detail
<0.001 Turcot syndrome (disorder) NA BeFree Detail
<0.001 Autosomal dominant hereditary disorder NA BeFree Detail
0.002 Congenital digestive system anomalies NA GAD Detail
<0.001 Congenital anomaly of the kidney NA BeFree Detail
0.120 Unilateral agenesis of kidney NA ORPHANET Detail
0.001 Amyloidosis, Primary Cutaneous NA BeFree Detail
<0.001 Familial lichen amyloidosis NA BeFree Detail
<0.001 Parathyroid hyperplasia NA BeFree Detail
<0.001 metastatic parathyroid cancer NA BeFree Detail
<0.001 Solid tumour NA BeFree Detail
<0.001 secondary acute myeloid leukemia NA BeFree Detail
<0.001 Adenocarcinoma of pancreas NA BeFree Detail
<0.001 Dermatitis verrucosa In vitro siRNA RET/PTC3 showed significant (p<0.001) inhibitory effects on RP3 c... BeFree 24759995 Detail
<0.001 Adenomatous goiter NA BeFree Detail
<0.001 inflammatory myofibroblastic tumor Molecular characterization of inflammatory myofibroblastic tumors with frequent ... BeFree 25723109 Detail
<0.001 Carcinoid tumor no ICD-O subtype NA BeFree Detail
<0.001 Ganglioneuromatosis NA BeFree Detail
<0.001 psammomatous meningioma Our findings suggest that the combination of lymphangitic spread and psammoma bo... BeFree 25436805 Detail
<0.001 multinodular goiter NA BeFree Detail
<0.001 Short segment Hirschsprung's disease NA BeFree Detail
0.002 Total intestinal aganglionosis NA BeFree Detail
<0.001 Neuronal intestinal dysplasia NA BeFree Detail
0.002 Malignant neoplasm of pancreas NA BeFree Detail
<0.001 Early gastric cancer NA BeFree Detail
<0.001 Hematopoietic Neoplasms NA BeFree Detail
<0.001 Hematologic Neoplasms NA BeFree Detail
<0.001 Primary vesicoureteric reflux NA BeFree Detail
<0.001 Carney complex NA BeFree Detail
<0.001 Gastrointestinal symptom In families with MEN2A and known exon 10 RET mutations, the threshold for invest... BeFree 24972642 Detail
<0.001 Mandibuloacral dysostosis NA BeFree Detail
<0.001 Follicular neoplasm NA BeFree Detail
<0.001 Papillary neoplasm NA BeFree Detail
<0.001 Secondary malignant neoplasm of liver NA BeFree Detail
<0.001 Benign neurologic neoplasms NA BeFree Detail
0.002 Sleep Apnea, Obstructive NA GAD Detail
0.001 Congenital absence of kidney NA BeFree Detail
0.024 Carcinogenesis A mouse model of KIF5B-RET fusion-dependent lung tumorigenesis. BeFree 25064355 Detail
0.024 Carcinogenesis Up-regulation of miR-146a and miR-146b expression in tissues was related to carc... BeFree 25524940 Detail
0.024 Carcinogenesis Although RET point mutation has been identified as a driver of tumorigenesis in ... BeFree 25546157 Detail
0.024 Carcinogenesis The presence of the PIK3CA mutation and the wild-type KRAS, BRAF, CTNNB1 genes, ... BeFree 26054797 Detail
0.006 Hashimoto Disease NA BeFree,LHGDN Detail
<0.001 Progressive Neoplastic Disease One asymptomatic carrier had de novo codon 918 mutation (MEN2B) and showed bilat... BeFree 26033033 Detail
<0.001 Stage II Colorectal Cancer NA BeFree Detail
0.003 breast carcinoma Targeting RET-interleukin-6 crosstalk to impair metastatic dissemination in brea... BeFree 24467886 Detail
0.005 Carcinoma of lung Oncogenic fusion of the RET (rearranged during transfection) gene was recently i... BeFree 25064355 Detail
0.005 Carcinoma of lung The decreased MARVELD1 level in lung cancer reduces NMD efficiency through dimin... BeFree 25520033 Detail
0.005 Carcinoma of lung Oncogenic RET tyrosine kinase gene fusions and activating mutations have recentl... BeFree 25546157 Detail
0.005 Secondary malignant neoplasm of lymph node Positive associations were found between levels of miR-146a expression in PTC ti... BeFree 25524940 Detail
0.005 Secondary malignant neoplasm of lymph node One asymptomatic carrier had de novo codon 918 mutation (MEN2B) and showed bilat... BeFree 26033033 Detail
<0.001 Parathyroid Gland Adenocarcinoma NA BeFree Detail
<0.001 colon carcinoma NA BeFree Detail
<0.001 stomach carcinoma NA BeFree Detail
<0.001 Carcinoma of bladder Potentially druggable kinase fusions involving ALK, ROS, RET, NTRK and FGFR gene... BeFree 25500544 Detail
0.009 Central neuroblastoma We developed a RET mini-gene reporter system, and showed that MCS+9.7 enhanced H... BeFree 24794774 Detail
0.120 Amyloidosis, Familial NA CTD_human Detail
<0.001 thyroid nodule solitary NA BeFree Detail
<0.001 trisomy 2 NA BeFree Detail
<0.001 Marden-Walker syndrome NA BeFree Detail
<0.001 malignant pleural mesothelioma NA BeFree Detail
<0.001 Rhabdoid Tumor of the Kidney Investigating RET RTK signaling pathways using an IAP-based activity-profiling a... BeFree 24942550 Detail
<0.001 Adenocarcinoma of lung, stage IV Clinical and prognostic implications of RET rearrangements in metastatic lung ad... BeFree 25773866 Detail
<0.001 Intraepithelial Neoplasia NA BeFree Detail
<0.001 Mucosal neuromas NA BeFree Detail
<0.001 autoimmune thyroiditis NA BeFree Detail
<0.001 cancer recurrence NA BeFree Detail
<0.001 Chromosome 17 trisomy NA BeFree Detail
0.003 Malignant neoplasm of ovary NA BeFree,GAD Detail
<0.001 Pheochromocytoma, Extra-Adrenal NA BeFree Detail
<0.001 Poorly Differentiated Thyroid Carcinoma NA BeFree Detail
<0.001 Papillary microcarcinoma NA BeFree Detail
0.241 Congenital central hypoventilation NA BeFree,CTD_human,UNIPROT Detail
<0.001 Chronic myeloproliferative disorder NA BeFree Detail
<0.001 Single tumor NA BeFree Detail
<0.001 Non-toxic nodular goiter Levels of miR-146a and miR-146b expression in PTC tissues were higher compared t... BeFree 25524940 Detail
<0.001 Adenocarcinoma of large intestine NA BeFree Detail
<0.001 Desmoplastic melanoma We investigated the expression of p75NGFR and TrkA, and the presence of function... BeFree 25752716 Detail
0.002 Hereditary Malignant Neoplasm NA BeFree Detail
<0.001 Paragangliomas, head and neck NA BeFree Detail
0.002 Necrotic changes (finding) NA GAD Detail
<0.001 Neuroblastic Tumor NA BeFree Detail
<0.001 thyroid hyalinizing trabecular adenoma NA BeFree Detail
0.002 differentiated thyroid gland carcinoma The aim of this case-control study was to determine the effect of four well know... BeFree 25330015 Detail
0.002 C-cell hyperplasia NA GAD Detail
0.003 Mammary Neoplasms NA LHGDN Detail
<0.001 drug dependence NA BeFree Detail
<0.001 Benign Struma Ovarii NA BeFree Detail
<0.001 Malignant Conversion NA BeFree Detail
<0.001 Xenograft Model NA BeFree Detail
0.001 colorectal cancer NA BeFree Detail
0.241 Congenital absence of kidneys syndrome NA BeFree,CTD_human,ORPHANET Detail
<0.001 RENAL ADYSPLASIA NA BeFree Detail
<0.001 androgen independent prostate cancer NA BeFree Detail
0.001 Hyperparathyroidism-Jaw Tumor Syndrome NA BeFree Detail
<0.001 Neonatal Deformity NA BeFree Detail
<0.001 Hereditary Paraganglioma-Pheochromocytoma Syndrome Hereditary paraganglioma-pheochromocytoma syndromes associated with SDHD and RET... BeFree 24375508 Detail
0.001 Non-Neoplastic Disorder NA BeFree Detail
0.522 familial medullary thyroid carcinoma Mutation of the RET proto-oncogene is known to be responsible for development of... BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT 24805091 Detail
0.522 familial medullary thyroid carcinoma Systematic prophylactic total thyroidectomy in patients with a RET proto-oncogen... BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT 24993783 Detail
0.522 familial medullary thyroid carcinoma Children belonging to families with FMTC are usually identified by RET genetic s... BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT 25231454 Detail
0.522 familial medullary thyroid carcinoma The American Thyroid Association (ATA) medullary thyroid cancer (MTC) guidelines... BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT 25733075 Detail
0.002 Thyroid carcinoma, sporadic medullary NA GAD Detail
<0.001 Bulbo-Spinal Atrophy, X-Linked NA BeFree Detail
<0.001 Waardenburg syndrome type 1 NA BeFree Detail
<0.001 WAARDENBURG SYNDROME, TYPE 4A NA BeFree Detail
<0.001 Myeloproliferative disorder, chronic, with eosinophilia Metastatic RET-rearranged lung adenocarcinoma patients with MPE might have favor... BeFree 25773866 Detail
<0.001 PITUITARY ADENOMA PREDISPOSITION (disorder) NA BeFree Detail
0.001 HYPERPARATHYROIDISM 3 NA BeFree Detail
0.001 Multiple endocrine neoplasia (MEN) Syndrome NA BeFree Detail
<0.001 liver carcinoma Overexpression of miR-218 inhibits hepatocellular carcinoma cell growth through ... BeFree 25374061 Detail
<0.001 Neural crest tumor NA BeFree Detail
<0.001 aggressive cancer NA BeFree Detail
<0.001 Stage II Colorectal Cancer AJCC v7 NA BeFree Detail
0.003 Hypoventilation NA LHGDN Detail
<0.001 Nonmedullary Thyroid Carcinoma NA BeFree Detail
<0.001 Progressive cGVHD One asymptomatic carrier had de novo codon 918 mutation (MEN2B) and showed bilat... BeFree 26033033 Detail
<0.001 Congenital Intestinal Aganglionosis NA BeFree Detail
0.002 Cutaneous lichen amyloidosis NA GAD Detail
<0.001 Experimental Organism Basal Cell Carcinoma NA BeFree Detail
<0.001 Papillary carcinoma of the breast NA BeFree Detail
0.002 Medullary sponge kidney disease NA GAD Detail
0.003 Congenital Abnormality NA BeFree Detail
<0.001 Apert syndrome NA BeFree Detail
0.004 adenocarcinoma NA BeFree Detail
0.002 papillary adenocarcinoma NA GAD Detail
0.007 adenoma NA BeFree,LHGDN Detail
0.027 Adrenal Gland Neoplasms NA BeFree,GAD Detail
<0.001 Primary myelofibrosis NA BeFree Detail
<0.001 Alcoholic Intoxication, Chronic NA BeFree Detail
<0.001 amyotrophic lateral sclerosis NA BeFree Detail
<0.001 Anaplasia This review will cover several cellular signaling pathways and mechanisms, inclu... BeFree 25260367 Detail
<0.001 supravalvular aortic stenosis NA BeFree Detail
0.002 atherosclerosis NA GAD Detail
<0.001 Basal Cell Nevus Syndrome NA BeFree Detail
0.002 Malignant neoplasm of urinary bladder NA GAD Detail
<0.001 Brain Neoplasms NA BeFree Detail
0.002 Malignant neoplasm of breast Targeting RET-interleukin-6 crosstalk to impair metastatic dissemination in brea... BeFree 24467886 Detail
0.120 Burkitt lymphoma NA CTD_human Detail
<0.001 Carcinoid Tumor NA BeFree Detail
<0.001 Malignant tumor of colon NA BeFree Detail
0.005 Non-small cell lung carcinoma Coupled with the presence of RET fusion proteins in non-small-cell lung cancer, ... BeFree 25122427 Detail
0.005 Non-small cell lung carcinoma Alectinib shows potent antitumor activity against RET-rearranged non-small cell ... BeFree 25349307 Detail
0.005 Non-small cell lung carcinoma A mass spectrometry assay to simultaneously analyze ROS1 and RET fusion gene exp... BeFree 25384172 Detail
0.005 Non-small cell lung carcinoma Multiplex RT-PCR from specimens of MPE is feasible for the screening of RET rear... BeFree 25773866 Detail
0.005 Non-small cell lung carcinoma To evaluate the frequency and clinicopathological features of ROS1 and RET rearr... BeFree 25905642 Detail
0.029 Carcinoma, Papillary NA BeFree,GAD,LHGDN Detail
Annotation

Annotations

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Levels of miR-146a and miR-146b expression in PTC tissues were higher compared to the nodular goiter... DisGeNET Detail
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Accordingly, knockdown of SPIN1 or MAZ results in reduced levels of GDNF and activated RET explainin... DisGeNET Detail
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The results suggest that the RET fusion functions as a driver for the development of lung tumors, wh... DisGeNET Detail
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These results indicate that TERT promoter mutations are associated with the development of distant m... DisGeNET Detail
However, the prevalence, clinical characteristics, and outcome of patients with RET-rearranged lung ... DisGeNET Detail
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Mutation of the RET proto-oncogene is known to be responsible for development of FMTC and for multip... DisGeNET Detail
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We developed a RET mini-gene reporter system, and showed that MCS+9.7 enhanced HOXB5 trans-activatio... DisGeNET Detail
HNPGs in patients with rearranged during transfection (RET), neurofibromatosis type 1 (NF1), and MYC... DisGeNET Detail
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Elevated thyroid nodule risks were associated with the minor alleles of RET S836S (rs1800862, P = 0.... DisGeNET Detail
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We report a FAP-associated CMVPTC tumor with atypically aggressive features harboring a RAS mutation... DisGeNET Detail
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A molecular profile including BRAF and RAS mutations as well as RET/PTC rearrangement evaluation has... DisGeNET Detail
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Clinical and prognostic implications of RET rearrangements in metastatic lung adenocarcinoma patient... DisGeNET Detail
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In further subgroup analysis, the RET-CSGALNACT2-RASGEF1A genomic region was observed to have differ... DisGeNET Detail
Cumulative effects of the RET and EDNRB genes contribute to long-segment and total colonic aganglion... DisGeNET Detail
NA DisGeNET Detail
RET mutation and expression in small-cell lung cancer. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
This study constructed and analyzed transgenic mice expressing KIF5B-RET, the predominant form of RE... DisGeNET Detail
Further analysis of RET mRNA expression in SCLC revealed wide variability in both cells and tumors, ... DisGeNET Detail
RET-rearranged lung adenocarcinomas with lymphangitic spread, psammoma bodies, and clinical response... DisGeNET Detail
We analyzed 214 mutations across 26 lung cancer-associated genes and three fusion genes using the Ma... DisGeNET Detail
However, the prevalence, clinical characteristics, and outcome of patients with RET-rearranged lung ... DisGeNET Detail
This report delivers a comprehensive genetic alteration profile of lung adenocarcinomas (LADC) drive... DisGeNET Detail
Among these, RET fusion transcripts are detectable in about 1-2% of lung adenocarcinomas and might r... DisGeNET Detail
Decoding Tumor Phenotypes for ALK, ROS1, and RET Fusions in Lung Adenocarcinoma Using a Radiomics Ap... DisGeNET Detail
Persephin: A potential key component in human oral cancer progression through the RET receptor tyros... DisGeNET Detail
The majority of the observed loci do not overlap with coding sequences; however, several observed ge... DisGeNET Detail
NA DisGeNET Detail
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Combining several agents would seem to be more promising, in particular agents that target RET with ... DisGeNET Detail
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Next generation sequencing analysis of platinum refractory advanced germ cell tumor sensitive to Sun... DisGeNET Detail
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RET/PTC mutations are often discovered both in papillary and in medullary carcinomas, while B-RAF mu... DisGeNET Detail
Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations in the rearra... DisGeNET Detail
Persephin: A potential key component in human oral cancer progression through the RET receptor tyros... DisGeNET Detail
The multiple endocrine neoplasia type 2A (MEN 2A) syndrome, comprising medullary thyroid carcinoma (... DisGeNET Detail
MEN2A represents more than 50% of all MEN2 cases, having a regular pattern with medullary thyroid ca... DisGeNET Detail
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Genetically engineered models of papillary and undifferentiated (anaplastic) thyroid carcinoma (PTC ... DisGeNET Detail
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Oncogenic fusion of the RET (rearranged during transfection) gene was recently identified as a novel... DisGeNET Detail
The decreased MARVELD1 level in lung cancer reduces NMD efficiency through diminishing the associati... DisGeNET Detail
Oncogenic RET tyrosine kinase gene fusions and activating mutations have recently been identified in... DisGeNET Detail
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The mice expressed the KIF5B-RET fusion gene specifically in lung alveolar epithelial cells, and dev... DisGeNET Detail
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In vitro siRNA RET/PTC3 showed significant (p<0.001) inhibitory effects on RP3 cell viability (MTT a... DisGeNET Detail
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Molecular characterization of inflammatory myofibroblastic tumors with frequent ALK and ROS1 gene fu... DisGeNET Detail
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Our findings suggest that the combination of lymphangitic spread and psammoma bodies may be characte... DisGeNET Detail
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In families with MEN2A and known exon 10 RET mutations, the threshold for investigation for HSCR in ... DisGeNET Detail
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A mouse model of KIF5B-RET fusion-dependent lung tumorigenesis. DisGeNET Detail
Up-regulation of miR-146a and miR-146b expression in tissues was related to carcinogenesis and deter... DisGeNET Detail
Although RET point mutation has been identified as a driver of tumorigenesis in medullary thyroid ca... DisGeNET Detail
The presence of the PIK3CA mutation and the wild-type KRAS, BRAF, CTNNB1 genes, and the intact PTEN ... DisGeNET Detail
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One asymptomatic carrier had de novo codon 918 mutation (MEN2B) and showed bilateral microcarcinoma ... DisGeNET Detail
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Targeting RET-interleukin-6 crosstalk to impair metastatic dissemination in breast cancer. DisGeNET Detail
Oncogenic fusion of the RET (rearranged during transfection) gene was recently identified as a novel... DisGeNET Detail
The decreased MARVELD1 level in lung cancer reduces NMD efficiency through diminishing the associati... DisGeNET Detail
Oncogenic RET tyrosine kinase gene fusions and activating mutations have recently been identified in... DisGeNET Detail
Positive associations were found between levels of miR-146a expression in PTC tissues and gender (fe... DisGeNET Detail
One asymptomatic carrier had de novo codon 918 mutation (MEN2B) and showed bilateral microcarcinoma ... DisGeNET Detail
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Potentially druggable kinase fusions involving ALK, ROS, RET, NTRK and FGFR gene families were detec... DisGeNET Detail
We developed a RET mini-gene reporter system, and showed that MCS+9.7 enhanced HOXB5 trans-activatio... DisGeNET Detail
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Investigating RET RTK signaling pathways using an IAP-based activity-profiling approach. DisGeNET Detail
Clinical and prognostic implications of RET rearrangements in metastatic lung adenocarcinoma patient... DisGeNET Detail
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Levels of miR-146a and miR-146b expression in PTC tissues were higher compared to the nodular goiter... DisGeNET Detail
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We investigated the expression of p75NGFR and TrkA, and the presence of functional RET polymorphism ... DisGeNET Detail
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The aim of this case-control study was to determine the effect of four well known RET single nucleot... DisGeNET Detail
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Hereditary paraganglioma-pheochromocytoma syndromes associated with SDHD and RET mutations. DisGeNET Detail
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Mutation of the RET proto-oncogene is known to be responsible for development of FMTC and for multip... DisGeNET Detail
Systematic prophylactic total thyroidectomy in patients with a RET proto-oncogene mutation allowed e... DisGeNET Detail
Children belonging to families with FMTC are usually identified by RET genetic screening shortly aft... DisGeNET Detail
The American Thyroid Association (ATA) medullary thyroid cancer (MTC) guidelines group RET variants,... DisGeNET Detail
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Metastatic RET-rearranged lung adenocarcinoma patients with MPE might have favorable survival compar... DisGeNET Detail
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Overexpression of miR-218 inhibits hepatocellular carcinoma cell growth through RET. DisGeNET Detail
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One asymptomatic carrier had de novo codon 918 mutation (MEN2B) and showed bilateral microcarcinoma ... DisGeNET Detail
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This review will cover several cellular signaling pathways and mechanisms, including RET/PTC, RAS, B... DisGeNET Detail
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Targeting RET-interleukin-6 crosstalk to impair metastatic dissemination in breast cancer. DisGeNET Detail
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Coupled with the presence of RET fusion proteins in non-small-cell lung cancer, our data indicate an... DisGeNET Detail
Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer. DisGeNET Detail
A mass spectrometry assay to simultaneously analyze ROS1 and RET fusion gene expression in non-small... DisGeNET Detail
Multiplex RT-PCR from specimens of MPE is feasible for the screening of RET rearrangements in NSCLC. DisGeNET Detail
To evaluate the frequency and clinicopathological features of ROS1 and RET rearrangements in N2 node... DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386545546 dbSNP
Genome
hg19
Position
chr10:43,572,516-43,625,799
Variant Type
snv
Variant (CIViC) (CIViC Variant)
MUTATION
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/1690
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