Doxorubicin

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Information
Drug Name
Doxorubicin
Description
Entry(CIViC)
14
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
pancreatic adenocarcinoma RB1 OVEREXPRESSION
( ENST00000267163.6 ) RB1 OVEREXPRESSION
( ENST00000267163.6 )
D Predictive Supports Resistance Somatic 2 11792751 Detail
stomach carcinoma TP53 DELETERIOUS MUTATION TP53 DELETERIOUS MUTATION C Predictive Supports Sensitivity/Response Somatic 1 14514923 Detail
breast cancer TP53 p.Arg175His (p.R175H)
( ENST00000510385.5, ENST00000504937.5, ENST00000604348.6, ENST00000576024.2, ENST00000445888.6, ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000455263.6, ENST00000420246.6, ENST00000504290.5, ENST00000714357.1, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) TP53 p.Arg175His (p.R175H)
( ENST00000359597.8, ENST00000269305.9, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 )
D Predictive Supports Sensitivity/Response Somatic 3 22698404 Detail
breast cancer TP53 p.Arg249Thr (p.R249T)
( ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) TP53 p.Arg249Thr (p.R249T)
( ENST00000269305.9, ENST00000359597.8, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000413465.6, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 )
B Predictive Supports Sensitivity/Response Somatic 3 9569050 Detail
breast cancer PIK3CA MUTATION PIK3CA MUTATION B Predictive Does Not Support Sensitivity/Response Somatic 3 18371219 Detail
ovarian cancer LRP1B EXON 12-22 DELETION
( ENST00000389484.8 ) LRP1B EXON 12-22 DELETION
( ENST00000389484.8 )
D Predictive Supports Resistance Somatic 3 22896685 Detail
osteosarcoma TP53 p.Arg273His (p.R273H)
( ENST00000445888.6, ENST00000455263.6, ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) TP53 p.Arg273His (p.R273H)
( ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000714357.1, ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000714359.1, ENST00000610292.4, ENST00000610538.4, ENST00000714409.1, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000714408.1, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1 )
D Predictive Supports Resistance Somatic 3 17363498 Detail
childhood acute lymphocytic leukemia NT5C2 p.Arg375Gln (p.R375Q)
( ENST00000675985.1, ENST00000675326.1, ENST00000674860.1, ENST00000674696.1, ENST00000676449.1, ENST00000404739.8, ENST00000675645.1, ENST00000676428.1, ENST00000343289.9 ) NT5C2 p.Arg375Gln (p.R375Q)
( ENST00000343289.9, ENST00000404739.8, ENST00000674696.1, ENST00000674860.1, ENST00000675326.1, ENST00000675645.1, ENST00000675985.1, ENST00000676428.1, ENST00000676449.1 )
D Predictive Does Not Support Resistance Somatic 4 23377183 Detail
childhood acute lymphocytic leukemia NT5C2 p.Arg246Trp (p.R246W)
( ENST00000676428.1, ENST00000343289.9, ENST00000675985.1, ENST00000674696.1, ENST00000674860.1, ENST00000675326.1, ENST00000675645.1, ENST00000404739.8, ENST00000676449.1 ) NT5C2 p.Arg246Trp (p.R246W)
( ENST00000675985.1, ENST00000343289.9, ENST00000404739.8, ENST00000674696.1, ENST00000674860.1, ENST00000675326.1, ENST00000675645.1, ENST00000676428.1, ENST00000676449.1 )
D Predictive Does Not Support Resistance Somatic 4 23377183 Detail
childhood acute lymphocytic leukemia NT5C2 p.Ser453Phe (p.S453F)
( ENST00000676449.1, ENST00000675985.1, ENST00000404739.8, ENST00000675645.1, ENST00000674860.1, ENST00000675326.1, ENST00000674696.1, ENST00000343289.9, ENST00000676428.1 ) NT5C2 p.Ser453Phe (p.S453F)
( ENST00000674860.1, ENST00000675326.1, ENST00000343289.9, ENST00000404739.8, ENST00000674696.1, ENST00000675645.1, ENST00000675985.1, ENST00000676428.1, ENST00000676449.1 )
D Predictive Does Not Support Resistance Somatic 4 23377183 Detail
breast cancer TP53 DELETERIOUS MUTATION TP53 DELETERIOUS MUTATION D Predictive Supports Sensitivity/Response Somatic 4 22698404 Detail
mantle cell lymphoma ZEB1 EXPRESSION ZEB1 EXPRESSION D Predictive Supports Resistance N/A 2 24013721 Detail
mantle cell lymphoma ZEB1 EXPRESSION ZEB1 EXPRESSION D Predictive Supports Sensitivity/Response Somatic 3 24013721 Detail
breast cancer TOP2A EXPRESSION TOP2A EXPRESSION B Predictive Supports Sensitivity/Response N/A 2 15486187 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
In Capan-1 cell lines engineered to reduce pRB exp... RB1 RB1 OVEREXPRESSION
( ENST00000267163.6 ) RB1 OVEREXPRESSION
( ENST00000267163.6 )
Resitance or Non-Reponse true CIViC Evidence detail
In a study of 25 patients with advanced gastric ca... TP53 TP53 DELETERIOUS MUTATION TP53 DELETERIOUS MUTATION Sensitivity true CIViC Evidence detail
Breast tumors in a mouse model with R172H mutation... TP53 TP53 p.Arg175His (p.R175H)
( ENST00000510385.5, ENST00000504937.5, ENST00000604348.6, ENST00000576024.2, ENST00000445888.6, ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000455263.6, ENST00000420246.6, ENST00000504290.5, ENST00000714357.1, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) TP53 p.Arg175His (p.R175H)
( ENST00000359597.8, ENST00000269305.9, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 )
Sensitivity true CIViC Evidence detail
Breast tumors with R175H or R249 mutations are mor... TP53 TP53 p.Arg249Thr (p.R249T)
( ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) TP53 p.Arg249Thr (p.R249T)
( ENST00000269305.9, ENST00000359597.8, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000413465.6, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 )
Sensitivity true CIViC Evidence detail
This study of 140 patients with stage II-III breas... PIK3CA PIK3CA MUTATION PIK3CA MUTATION Sensitivity false CIViC Evidence detail
A minimum common region of deletion of 0.19Mb, enc... LRP1B LRP1B EXON 12-22 DELETION
( ENST00000389484.8 ) LRP1B EXON 12-22 DELETION
( ENST00000389484.8 )
Resitance or Non-Reponse true CIViC Evidence detail
Several preclinical studies were testing drug resi... TP53 TP53 p.Arg273His (p.R273H)
( ENST00000445888.6, ENST00000455263.6, ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) TP53 p.Arg273His (p.R273H)
( ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000714357.1, ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000714359.1, ENST00000610292.4, ENST00000610538.4, ENST00000714409.1, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000714408.1, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1 )
Resitance or Non-Reponse true CIViC Evidence detail
Lentiviral mediated overexpression of NT5C2 R367Q ... NT5C2 NT5C2 p.Arg375Gln (p.R375Q)
( ENST00000675985.1, ENST00000675326.1, ENST00000674860.1, ENST00000674696.1, ENST00000676449.1, ENST00000404739.8, ENST00000675645.1, ENST00000676428.1, ENST00000343289.9 ) NT5C2 p.Arg375Gln (p.R375Q)
( ENST00000343289.9, ENST00000404739.8, ENST00000674696.1, ENST00000674860.1, ENST00000675326.1, ENST00000675645.1, ENST00000675985.1, ENST00000676428.1, ENST00000676449.1 )
Resitance or Non-Reponse false CIViC Evidence detail
Overexpression of NT5C2 R238W in Reh cells resulte... NT5C2 NT5C2 p.Arg246Trp (p.R246W)
( ENST00000676428.1, ENST00000343289.9, ENST00000675985.1, ENST00000674696.1, ENST00000674860.1, ENST00000675326.1, ENST00000675645.1, ENST00000404739.8, ENST00000676449.1 ) NT5C2 p.Arg246Trp (p.R246W)
( ENST00000675985.1, ENST00000343289.9, ENST00000404739.8, ENST00000674696.1, ENST00000674860.1, ENST00000675326.1, ENST00000675645.1, ENST00000676428.1, ENST00000676449.1 )
Resitance or Non-Reponse false CIViC Evidence detail
Overexpression of NT5C2 S445F in Reh cells resulte... NT5C2 NT5C2 p.Ser453Phe (p.S453F)
( ENST00000676449.1, ENST00000675985.1, ENST00000404739.8, ENST00000675645.1, ENST00000674860.1, ENST00000675326.1, ENST00000674696.1, ENST00000343289.9, ENST00000676428.1 ) NT5C2 p.Ser453Phe (p.S453F)
( ENST00000674860.1, ENST00000675326.1, ENST00000343289.9, ENST00000404739.8, ENST00000674696.1, ENST00000675645.1, ENST00000675985.1, ENST00000676428.1, ENST00000676449.1 )
Resitance or Non-Reponse false CIViC Evidence detail
In this preclinical study, MMTV-Wnt1 mammary tumor... TP53 TP53 DELETERIOUS MUTATION TP53 DELETERIOUS MUTATION Sensitivity true CIViC Evidence detail
Downregulation of ZEB1 expression in mantle cell l... ZEB1 ZEB1 EXPRESSION ZEB1 EXPRESSION Resitance or Non-Reponse true CIViC Evidence detail
Downregulation of ZEB1 expression in mantle cell l... ZEB1 ZEB1 EXPRESSION ZEB1 EXPRESSION Sensitivity true CIViC Evidence detail
In a retrospective study, TOP2A expression was ass... TOP2A TOP2A EXPRESSION TOP2A EXPRESSION Sensitivity true CIViC Evidence detail
The tumor suppressor SNF5, the core subunit of SWI... SMARCB1 SMARCB1 UNDEREXPRESSION Resitance or Non-Reponse true MMMP detail
MITF amplification does not predict chemosensitivi... MITF MITF AMP Resitance or Non-Reponse true MMMP detail
Blocking the expression of APP by RNA interference... APP APP UNDEREXPRESSION Sensitivity true MMMP detail
Antagonistic combinations with imexon included dox... ROS1 ROS1 OVEREXPRESSION Resitance or Non-Reponse true MMMP detail
The ATF2 peptide spanning amino acids 50-100 - whi... ATF2 ATF2 UNDEREXPRESSION Sensitivity true MMMP detail
Verified also in vivo in a mouse model HMGCR HMGCR UNDEREXPRESSION Sensitivity true MMMP detail
Besides expression/sensitivity correlation, ABCB5 ... ABCB5 ABCB5 UNDEREXPRESSION Sensitivity true MMMP detail
SMAC mimetics are SMAC derived peptides (SMAC phys... XIAP XIAP UNDEREXPRESSION Sensitivity true MMMP detail
KINK-1 ultimately acts by inhibiting NFkB (which i... IKBKB IKBKB UNDEREXPRESSION Sensitivity true MMMP detail
Vitamin D3 metabolites calcidiol and calcitriol di... VDR VDR OVEREXPRESSION Resitance or Non-Reponse true MMMP detail
Synergistic antiproliferative effects of the combi... IL1R1 IL1R1 OVEREXPRESSION Sensitivity true MMMP detail
In this phase I trial (dose finding) both melanoma... HDAC9 HDAC9 UNDEREXPRESSION Resitance or Non-Reponse true MMMP detail
NGR peptide is a ligand for CD13, which is express... ANPEP ANPEP UNKNOWN Sensitivity true MMMP detail
DEK (which is often upregulated in melanoma) trans... DEK DEK UNDEREXPRESSION Sensitivity true MMMP detail
STAT1-high tumor cells also demonstrate resistance... STAT1 STAT1 EXPRESSION Resitance or Non-Reponse true MMMP detail
ABCB8 mediates the resistance to doxorubicin (but ... ABCB8 ABCB8 UNDEREXPRESSION Sensitivity true MMMP detail
Glucose-regulated protein 78 antagonizes cisplatin... HSPA5 HSPA5 UNDEREXPRESSION Sensitivity true MMMP detail
HMW-MAA inhibition seems to act through inhibition... CSPG4 CSPG4 UNDEREXPRESSION Sensitivity true MMMP detail
Besides expression/sensitivity correlation, ABCB5 ... ABCB5 ABCB5 EXPRESSION Resitance or Non-Reponse true MMMP detail
In vivo experiments revealed that liposomal formul... MYC MYC UNDEREXPRESSION Sensitivity true MMMP detail
Adenovirus-mediated TA-p73beta gene transfer incre... ARHGAP24 ARHGAP24 OVEREXPRESSION Sensitivity true MMMP detail
Forced expression of transcription factor E2F1 (vi... E2F1 E2F1 OVEREXPRESSION Sensitivity true MMMP detail
Uveal melanoma TOP2B TOP2B EXPRESSION Resitance or Non-Reponse true MMMP detail
Uveal melanoma ABCB1 ABCB1 EXPRESSION Resitance or Non-Reponse true MMMP detail
Uveal melanoma ABCC1 ABCC1 EXPRESSION Resitance or Non-Reponse true MMMP detail
The sensitivity of melanoma cell lines to daunomyc... ABCC1 ABCC1 EXPRESSION Resitance or Non-Reponse true MMMP detail
The results indicate that although Muc4(+) cells e... MUC4 MUC4 EXPRESSION Resitance or Non-Reponse true MMMP detail
APAF1-negative melanomas are chemoresistant and ar... APAF1 APAF1 EXPRESSION Sensitivity true MMMP detail
bFGF overexpression can result in resistance again... FGF2 FGF2 EXPRESSION Resitance or Non-Reponse true MMMP detail
Non melanoma specific model (breast cancer). This ... CBR3 CBR3 UNKNOWN toxicity increased true MMMP detail
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NCT04024462 Active, not recruiting Phase 3 A Two-Arm Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Subcutaneous Administration of the Fixed-Dose Combination of Pertuzumab and Trastuzumab in Combination With Chemotherapy in Chinese Participants With HER2-Positive Early Breast Cancer February 5, 2020 November 11, 2025
NCT02180867 Active, not recruiting Phase 2/Phase 3 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery July 11, 2014 December 22, 2024
NCT04517435 Active, not recruiting Phase 1/Phase 2 ME-401 and R-CHOP in Newly Diagnosed Diffuse Large B-Cell Lymphoma April 28, 2021 July 2025
NCT02979522 Active, not recruiting Phase 1/Phase 2 A Study of Brentuximab Vedotin + Adriamycin, Vinblastine, and Dacarbazine in Pediatric Participants With Advanced Stage Newly Diagnosed Hodgkin Lymphoma September 6, 2017 September 24, 2029
NCT04083963 Active, not recruiting Phase 2 Phase 2 Trial of Neoadjuvant Weekly Carboplatin Plus Paclitaxel in Triple Negative Breast Cancer August 9, 2019 September 27, 2026
NCT03274492 Active, not recruiting Phase 3 A Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Diffuse Large B-Cell Lymphoma November 16, 2017 June 27, 2024
NCT05498896 Active, not recruiting Phase 2 Investigate the Contribution of Ipatasertib to Neoadjuvant Chemotherapy Plus Atezolizumab in TNBC December 19, 2018 January 30, 2026
NCT02957968 Active, not recruiting Phase 2 Neoadjuvant Pembrolizumab + Decitabine Followed by Std Neoadj Chemo for Locally Advanced HER2- Breast Ca January 24, 2017 February 28, 2025
NCT02911142 Active, not recruiting Phase 1/Phase 2 Lenalidomide Combined With Modified DA-EPOCH and Rituximab (EPOCH-R2) in Primary Effusion Lymphoma or KSHV-associated Large Cell Lymphoma July 3, 2017 October 1, 2027
NCT03646123 Active, not recruiting Phase 2 Clinical Trial of Brentuximab Vedotin in Classical Hodgkin Lymphoma January 28, 2019 June 7, 2026
NCT05275777 Active, not recruiting Phase 1/Phase 2 A Phase Ib Safety lead-in, Followed by Phase II Trial of ADG106 in Combination With Neoadjuvant Chemotherapy in HER2 Negative Breast Cancer May 19, 2022 February 2030
NCT02306161 Active, not recruiting Phase 3 Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma December 12, 2014 September 22, 2024
NCT03817320 Active, not recruiting Phase 1/Phase 2 PO Ixazomib in Combination With Chemotherapy for Childhood Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma February 12, 2019 June 30, 2025
NCT03595592 Active, not recruiting Phase 3 Neoadjuvant Treatment of HER2 Positive Early High-risk and Locally Advanced Breast Cancer September 7, 2018 March 15, 2027
NCT02889523 Active, not recruiting Phase 1/Phase 2 Study of Tazemetostat in Newly Diagnosed Diffuse Large B Cell and Follicular Lymphoma Patients Treated by Chemiotherapy October 2016 April 2026
NCT02876302 Active, not recruiting Phase 2 Study Of Ruxolitinib (INCB018424) With Preoperative Chemotherapy For Triple Negative Inflammatory Breast Cancer January 24, 2018 August 2024
NCT03233347 Active, not recruiting Phase 2 Doxorubicin, Vinblastine, Dacarbazine, Brentuximab Vedotin, and Nivolumab in Treating Patients With Stage I-II Hodgkin Lymphoma October 13, 2017 July 8, 2025
NCT02451943 Active, not recruiting Phase 3 A Study of Doxorubicin Plus Olaratumab (LY3012207) in Participants With Advanced or Metastatic Soft Tissue Sarcoma September 14, 2015 July 31, 2024
NCT03159897 Active, not recruiting Phase 3 FIL Study on ABVD DD-DI as Upfront Therapy in HL. August 1, 2017 May 2024
NCT03587662 Active, not recruiting Phase 2 Ixazomib, Gemcitabine, and Doxorubicin in Treating Patients With Locally Advanced or Metastatic Kidney Cancer August 17, 2018 January 31, 2025
NCT03117751 Active, not recruiting Phase 2/Phase 3 Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma March 29, 2017 March 31, 2028
NCT00006721 Active, not recruiting Phase 3 S0016 Combination Chemotherapy With Monoclonal Antibody Therapy in Newly Diagnosed Non-Hodgkin's Lymphoma March 2001 March 2024
NCT01712490 Active, not recruiting Phase 3 A Frontline Therapy Trial in Participants With Advanced Classical Hodgkin Lymphoma November 9, 2012 January 13, 2026
NCT03113500 Active, not recruiting Phase 2 Brentuximab Vedotin and Combination Chemotherapy in Treating Patients With CD30-Positive Peripheral T-cell Lymphoma May 25, 2017 December 21, 2024
NCT03101748 Active, not recruiting Phase 1/Phase 2 Neratinib and Paclitaxel With or Without Pertuzumab and Trastuzumab Before Combination Chemotherapy in Treating Patients With Metastatic or Locally Advanced Breast Cancer January 29, 2018 January 1, 2026
NCT02419495 Active, not recruiting Phase 1 Phase IB Study to Evaluate the Safety of Selinexor (KPT-330) in Combination With Multiple Standard Chemotherapy or Immunotherapy Agents in Patients With Advanced Malignancies June 26, 2015 December 31, 2024
NCT01746238 Active, not recruiting Phase 1 Bevacizumab/Doxorubicin/Radiation for Sarcoma March 2013 January 2025
NCT02734771 Active, not recruiting Phase 2 A Study of Brentuximab Vedotin, Rituximab, and Dose Attenuated CHP in Elderly Patients With Diffuse Large B-Cell Lymphoma (DLBCL) June 2016 June 2024
NCT02723994 Active, not recruiting Phase 2 A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic Leukemia September 30, 2016 February 1, 2026
NCT02427620 Active, not recruiting Phase 2 Ibrutinib, Rituximab, and Consolidation Chemotherapy in Treating Young Patients With Newly Diagnosed Mantle Cell Lymphoma June 3, 2015 June 30, 2025
NCT02710734 Active, not recruiting Phase 2 Risk Enabled Therapy After Initiating Neoadjuvant Chemotherapy for Bladder Cancer (RETAIN) February 24, 2016 February 2034
NCT05218499 Active, not recruiting Phase 2/Phase 3 Brightline-1: A Study to Compare Brigimadlin (BI 907828) With Doxorubicin in People With a Type of Cancer Called Dedifferentiated Liposarcoma March 25, 2022 May 27, 2026
NCT00878254 Active, not recruiting Phase 2 Rituximab and Combination Chemotherapy in Treating Patients With Previously Untreated Mantle Cell Lymphoma March 25, 2009 September 2027
NCT05008224 Active, not recruiting Phase 2 Study of Safety and Efficacy of Pembrolizumab and Chemotherapy in Participants With Newly Diagnosed Classical Hodgkin Lymphoma (cHL) (MK-3475-C11/KEYNOTE-C11) October 7, 2021 May 22, 2024
NCT02661503 Active, not recruiting Phase 3 HD21 for Advanced Stages July 2016 September 2025
NCT00471965 Completed Phase 3 Oxaliplatin + 5-FluoroUracil/LeucoVorin (5-FU/LV) (FOLFOX4) Versus Doxorubicin as Palliative Chemotherapy in Advanced Hepatocellular Carcinoma Patients March 2007 March 2010
NCT00477412 Completed Phase 1/Phase 2 Bortezomib, Rituximab and Combination Chemotherapy in Treating Participants With Mantle Cell Lymphoma April 3, 2007 October 28, 2020
NCT00483509 Completed Phase 2 Study of NGR-hTNF in Combination With Doxorubicin in Patients Affected by Metastatic Small Cell Lung Carcinoma February 14, 2007 May 17, 2011
NCT00484341 Completed Phase 2 Phase II Study of NGR-hTNF in Combination With Doxorubicin in Patients Affected by Soft Tissue Sarcomas. October 2010 May 2016
NCT00484432 Completed Phase 2 Study of NGR-hTNF in Combination With Doxorubicin in Patients Affected by Advanced or Metastatic Ovarian Cancer November 2008 June 2016
NCT00493870 Completed Phase 3 TAC Versus TC for Adjuvant Breast Cancer May 29, 2007 March 30, 2020
NCT00494780 Completed Phase 2 Ofatumumab (Humax-CD20) With CHOP (Cyclophosphamide,Doxorubicin, Vincristine, Predisolone) in Follicular Lymphoma (FL) Patients June 2007 September 2010
NCT00499122 Completed Phase 2 NOV-002, Doxorubicin, Cyclophosphamide, and Docetaxel in Women With Newly Diagnosed Stage II or IIIC Breast Cancer June 4, 2007 April 2011
NCT00502411 Completed Phase 1 Post-Operative Chemoradiation for Extremity & Trunk Soft Tissue Sarcoma January 2003 April 2015
NCT00506155 Completed Phase 2 Neoadjuvant Chemotherapy With Methotrexate, Vinblastine, Adriamycin and Cisplatin (M-VAC) Plus Avastin in Patients With Urothelial Cancer June 2007 August 2014
NCT00510367 Completed Early Phase 1 Primary Breast Cancer Occurring Concomitant With Pregnancy August 7, 2001 July 8, 2020
NCT00530101 Completed Phase 1 The Magnetic Resonance Imaging Evaluation of Doxorubicin Cardiotoxicity July 2004 March 2008
NCT00536393 Completed Phase 2/Phase 3 Treatment of Disseminated High Grade Lymphoma October 2000 October 2004
NCT00544167 Completed N/A Adjuvant Doxorubicin/Cyclophosphamide and Paclitaxel Plus Sorafenib Breast Cancer May 2007 April 2011
NCT00546156 Completed Phase 2 Preoperative Dose-dense Doxorubicin and Cyclophosphamide Followed by Paclitaxel With Bevacizumab in Operable Breast Cancer October 2007 December 2012
NCT00574587 Completed Phase 1/Phase 2 Trial for Locally Advanced Breast Cancer Using Vorinostat Plus Chemotherapy December 2007 May 2014
NCT00575406 Completed Phase 2 Multicentre Study to Determine the Cardiotoxicity of R-CHOP Compared to R-COMP in Patients With Diffuse Large B-Cell Lymphoma December 2007 January 2012
NCT00577629 Completed Phase 2 Chemotherapy With Monoclonal Antibody and Radioimmunotherapy for High-Risk B-Cell Non-Hodgkins Lymphoma June 18, 2005 November 3, 2016
NCT00577993 Completed Phase 3 Fludarabine, Mitoxantrone, and Dexamethasone (FND) Plus Rituximab for Lymphoma Patients March 16, 1998 August 24, 2017
NCT00578864 Completed Phase 2 Protracted Etoposide During Induction Therapy for High Risk Neuroblastoma March 2007 March 2015
NCT00580333 Completed Phase 2 Preoperative Cisplatin and Bevacizumab in ER-, PR-, HER2 Negative Breast Cancer September 2007 June 2020
NCT00581776 Completed Phase 2 Phase II Study of VcR-CVAD With Rituximab Consolidation and Maintenance for Untreated Mantle Cell Lymphoma May 2005 May 2015
NCT00586846 Completed Phase 2 Phase II Study of Chemotherapy and Pamidronate for the Treatment of Newly Diagnosed Osteosarcoma July 2003 February 2009
NCT00590785 Completed Phase 3 Phase III Comparison of Adjuvant Chemotherapy W/High-Dose Cyclophosphamide Plus Doxorubicin (AC) vs Sequential Doxorubicin Fol by Cyclophosphamide (A-C) in High Risk Breast Cancer Patients With 0-3 Positive Nodes (Intergroup, CALGB 9394) August 13, 1996 January 13, 2015
NCT00613457 Completed Phase 3 Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia September 2000 July 2006
NCT00626704 Completed Phase 1/Phase 2 Phase 1b/2 Study of AMG 655 With Doxorubicin for the First-Line Treatment of Unresectable Soft Tissue Sarcoma November 2007 March 2011
NCT00634179 Completed Phase 1/Phase 2 A Phase I/II Trial of VR-CHOP in Lymphoma Patients February 2008 November 2015
NCT04081389 Completed Phase 1 Chemokine Modulation Therapy and Standard Chemotherapy Before Surgery for the Treatment of Early Stage Triple Negative Breast Cancer December 6, 2019 February 27, 2023
NCT00651755 Completed N/A Aprepitant's Effect on Drug Metabolism in Multi-Day Combination (CHOP/R-CHOP) Chemotherapy Regimen in Lymphoma Patients March 2008 September 2011
NCT00667342 Completed Phase 2 A Study of Bevacizumab in Combination With Chemotherapy for Treatment of Osteosarcoma June 3, 2008 August 2017
NCT00669877 Completed Phase 2 Rituximab and Hyper-CVAD (Cyclophosphamide, Vincristine, Adriamycin, and Dexamethasone) for Burkitt's and Burkitt's -Like Leukemia/Lymphoma August 2002 October 2015
NCT00671658 Completed Phase 2 Modified Hyper-CVAD (Cyclophosphamide, Vincristine, Adriamycin, and Dexamethasone) Program for Acute Lymphoblastic Leukemia November 2002 July 2013
NCT00688740 Completed Phase 3 Docetaxel in Node Positive Adjuvant Breast Cancer June 1997 January 2010
NCT00715208 Completed Phase 2 Phase 2 Study of VELCADE (Bortezomib) in Patients With Relapsed Follicular Lymphoma September 2008 March 2011
NCT04047004 Completed Phase 1 Adjuvant PIPAC in Gastric Cancer Patients March 11, 2020 October 1, 2022
NCT00722293 Completed Phase 1 A Phase I, Open-label, Study of Pazopanib in Combination With Epirubicin or Doxorubicin for Advanced Solid Tumors July 8, 2008 February 25, 2014
NCT00770224 Completed Phase 2 S0801 Iodine I 131 Tositumomab, Rituximab, and Combination Chemotherapy in Previously Untreated Stage II, Stage III, or Stage IV Follicular Non-Hodgkin Lymphoma April 2009 August 2019
NCT00787527 Completed Phase 1/Phase 2 SAHA + CHOP in Untreated T-cell Non-Hodgkin's Lymphoma November 2008 December 2012
NCT00789581 Completed Phase 3 A Randomized Trial of Ixempra Versus Taxol in Adjuvant Therapy of Triple Negative Breast Cancer December 2008 November 2016
NCT00796120 Completed Phase 3 An Efficacy and Safety Study of Trabectedin Versus Doxorubicin-Based Chemotherapy in Participants With Translocation-Related Sarcomas (TRS) November 2008 August 2014
NCT00798252 Completed Phase 1 Ascending Multiple-Dose Study of Brivanib Alaninate in Combination With Chemotherapeutic Agents in Subjects With Advanced Cancers March 2009 May 2015
NCT00801281 Completed Phase 3 First-line R-CVP vs R-CHOP Induction Immunochemotherapy for Indolent Lymphoma and R Maintenance. February 2007 June 25, 2017
NCT00808639 Completed Phase 2 Dose-Dense MVAC With Pegfilgrastim Support in Subjects With Muscle-Invasive Urothelial Carcinoma December 2008 September 2016
NCT03991884 Completed Phase 1 Inotuzumab Ozogamicin and Chemotherapy in Treating Patients With Recurrent or Refractory B-cell Acute Lymphoblastic Leukemia September 24, 2019 June 28, 2023
NCT00814541 Completed Phase 2 PAD. ICORG 05-01, V11 December 2005 December 2012
NCT03817853 Completed Phase 4 An Open-Label, Single Arm Study of Obinutuzumab Short Duration Infusion in Patients With Previously Untreated Advanced Follicular Lymphoma February 26, 2019 January 25, 2023
NCT00825149 Completed Phase 1 A Study of Obinutuzumab in Combination With Chemotherapy in Participants With CD20+ B-Cell Follicular Non-Hodgkin's Lymphoma February 2009 November 2015
NCT03804866 Completed Phase 2 NGR-hTNF in Combination With an Anthracycline in Platinum-resistant Ovarian Cancer (NGR018) March 2013 December 2016
NCT00866749 Completed Phase 2 Augmented Berlin-Frankfurt-Munster (BFM) Therapy for Adolescent/Young Adults With Acute Lymphoblastic Leukemia or Acute Lymphoblastic Lymphoma September 12, 2006 July 26, 2018
NCT00877006 Completed Phase 3 Study of Bendamustine Hydrochloride and Rituximab (BR) Compared With R-CVP or R-CHOP in the First-Line Treatment of Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL) - Referred to as the BRIGHT Study April 30, 2009 March 31, 2012
NCT00878800 Completed Phase 1/Phase 2 A Phase I/II Clinical Trial of PXD101 in Combination With Doxorubicin in Patients With Soft Tissue Sarcomas December 2006 October 2012
NCT00887536 Completed Phase 3 A Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer May 2009 February 2018
NCT00890656 Completed Phase 2 Study of Augmented Hyper-CVAD in Acute Lymphoblastic Leukemia Salvage June 2003 January 2011
NCT00931918 Completed Phase 2 Study to Assess the Effectiveness of RCHOP With or Without VELCADE in Previously Untreated Non-Germinal Center B-Cell-like Diffuse Large B-Cell Lymphoma Patients October 2009 August 2015
NCT00944047 Completed Phase 2 Evaluate Trastuzumab Plus Standard Chemotherapy Given Before Surgery in Breast Cancer Patients With Low HER 2 Expression July 2009 August 2017
NCT00956930 Completed Phase 2 Chemoembolization Versus Radioembolization in Treating Patients With Liver Cancer That Cannot Be Treated With Radiofrequency Ablation Or Surgery August 2009 July 15, 2016
NCT00968253 Completed Phase 1/Phase 2 RAD001 Study in Treatment of Relapsed or Refractory Acute Lymphocytic Leukemia November 2009 December 2015
NCT00969462 Completed Phase 4 Doxorubicin Pharmacokinetics and Response in Non Hodgkin's Lymphoma September 2009 December 2012
NCT00973752 Completed Phase 2 Treatment of Older Adults With Acute Lymphoblastic Leukemia August 2009 April 2016
NCT00976131 Completed Phase 1 Study of CoQ10 During One Cycle of Doxorubicin Treatment for Breast Cancer September 2009 January 20, 2021
NCT00988195 Completed Phase 1 Study of Pegylated Human Recombinant Arginase for Liver Cancer May 2008 August 2009
NCT03726879 Completed Phase 3 A Study To Evaluate the Efficacy and Safety Of Atezolizumab or Placebo in Combination With Neoadjuvant Doxorubicin + Cyclophosphamide Followed By Paclitaxel + Trastuzumab + Pertuzumab In Early Her2-Positive Breast Cancer January 11, 2019 August 24, 2023
NCT01000285 Completed Phase 1/Phase 2 EPOCH Chemotherapy and Bortezomib for Associated T-Cell Leukemia Lymphoma September 2010 April 2016
NCT01004991 Completed Phase 1/Phase 2 Phase I/II Trial of R-CHOP + Azacytidine in Diffuse Large B Cell Lymphoma January 2010 February 2016
NCT01008150 Completed Phase 2 Phase II Randomized Trial Evaluating Neoadjuvant Therapy With Neratinib and/or Trastuzumab Followed by Postoperative Trastuzumab in Women With Locally Advanced HER2-positive Breast Cancer October 2010 November 25, 2016
NCT01027910 Completed Phase 1/Phase 2 PCI-24781 in Combination With Doxorubicin to Treat Sarcoma February 2009 March 2015
NCT01040871 Completed Phase 2 Study of the Combination of VELCADE, Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone or Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With Newly Diagnosed Non-Germinal Center B-Cell Subtype of Diffuse Large B-Cell Lymphoma January 2010 August 2012
NCT01060904 Completed Phase 1 A Phase 1 Study of Brentuximab Vedotin Combined With Multi-Agent Chemotherapy for Hodgkin Lymphoma January 2010 September 2012
NCT03677141 Completed Phase 1/Phase 2 A Phase Ib/II Study Investigating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With CHOP or CHP-Polatuzumab Vedotin in Participants With B-Cell Non-Hodgkin Lymphoma March 8, 2019 October 12, 2023
NCT01095926 Completed Phase 2 Pharmacokinetic Study of Doxorubicin in Children With Cancer May 2010 May 2013
NCT01148446 Completed Phase 3 R-CHOP Versus R-mini-CEOP in Elderly Patients(>65)With DLBCL January 2003
NCT03604653 Completed Trial of Cytoreductive Surgery and HIPEC in Patients With Primary and Secondary Peritoneal Cancers May 15, 2018 May 1, 2021
NCT01185964 Completed Phase 1/Phase 2 A Study of Olaratumab in Soft Tissue Sarcoma October 2010 April 2016
NCT01200758 Completed Phase 3 A Study of Rituximab (MabThera) Subcutaneous (SC) Versus Rituximab (MabThera) Intravenous in Participannts With Follicular Non-Hodgkin's Lymphoma February 15, 2011 October 31, 2017
NCT01205503 Completed Phase 2 Trial of Mesna to Prevent Doxorubicin-induced Plasma Protein Oxidation and Tumor Necrosis Factor Alpha (TNF-α) Release September 2010 April 2015
NCT03536039 Completed Phase 2 RCHOP Chemoimmunotherapy Preceded BY BBB Permeabilization by t-NGR Necrosis Factor January 27, 2016 January 27, 2020
NCT01251107 Completed Phase 3 Study Comparing ABVD vs BEACOPP in Advanced Hodgkin's Lymphoma March 2000 November 2009
NCT03493854 Completed Phase 3 A Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Subcutaneous Administration of the Fixed-Dose Combination of Pertuzumab and Trastuzumab in Combination With Chemotherapy in Participants With HER2-Positive Early Breast Cancer June 14, 2018 June 2, 2023
NCT01309789 Completed Phase 1 A Phase 1 Study of Brentuximab Vedotin Given Sequentially and Combined With Multi-Agent Chemotherapy for CD30-Positive Mature T-Cell and NK-Cell Neoplasms February 2011 February 28, 2017
NCT01319981 Completed Phase 2 Hyper-CVAD With Liposomal Vincristine in Acute Lymphoblastic Leukemia March 5, 2013 November 11, 2020
NCT01324180 Completed Phase 1 Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL) July 18, 2011 July 27, 2017
NCT03384654 Completed Phase 2 A Study to Evaluate the Efficacy and Safety of Daratumumab in Pediatric and Young Adult Participants Greater Than or Equal to (>=)1 and Less Than or Equal to (<=) 30 Years of Age With Relapsed/Refractory Precursor B-cell or T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma May 14, 2018 September 27, 2022
NCT01332968 Completed Phase 3 A Study of Obinutuzumab (RO5072759) Plus Chemotherapy in Comparison With Rituximab Plus Chemotherapy Followed by Obinutuzumab or Rituximab Maintenance in Patients With Untreated Advanced Indolent Non-Hodgkin's Lymphoma (GALLIUM) July 6, 2011 July 30, 2021
NCT02584309 Completed Phase 2 Doxorubicin With Upfront Dexrazoxane for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma February 22, 2016 July 17, 2022
NCT01358253 Completed Phase 4 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia December 2010 December 2012
NCT01375699 Completed Phase 1 Doxorubicin With or Without Sildenafil, With Analysis of Cardiac Markers August 11, 2011 January 19, 2018
NCT03349281 Completed Phase 1 Pevonedistat With VXLD Chemotherapy for Adolescent/Young Adults With Relapsed/Refractory ALL or Lymphoblastic NHL March 25, 2019 October 12, 2022
NCT01394354 Completed Phase 1/Phase 2 Vorinostat in Combination With Bortezomib, Doxorubicin and Dexamethasone (VBDD) in Patients With Refractory or Relapsed Multiple Myeloma (MM) August 2011 December 2015
NCT01414855 Completed Phase 2 A Study of Obinutuzumab [RO5072759 (GA101)] in Combination With CHOP Chemotherapy in Patients With Previously Untreated Advanced Diffuse Large B-Cell Lymphoma (GATHER) August 31, 2011 December 23, 2016
NCT03317457 Completed Phase 2 Durvalumab and Tremelimumab Compared to Doxorubicin in Patients With Advanced or Metastatic Soft Tissue Sarcoma December 15, 2017 August 12, 2022
NCT01440088 Completed Phase 3 A Trial of TH-302 in Combination With Doxorubicin Versus Doxorubicin Alone to Treat Patients With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma September 2011 May 2016
NCT01445535 Completed Phase 1 Phase 1 Trial of Siplizumab and Dose-Adjusted EPOCH-Rituximab in T- and NK-Cell Lymphomas January 13, 2009 October 22, 2020
NCT01451515 Completed Phase 2 NHL16: Study For Newly Diagnosed Patients With Acute Lymphoblastic Lymphoma May 25, 2012 May 31, 2022
NCT03301350 Completed Phase 2 Neoadjuvant Carbo/Paclitaxel Followed by Doxorubicin/Cyclophosphamide in Breast Cancer November 7, 2017 February 7, 2022
NCT01481194 Completed Phase 2 ACVDL Treatment for Patients With Newly Diagnosed Multiple Myeloma November 2011 August 28, 2018
NCT01490060 Completed N/A Fosaprepitant in Patients Receiving Ifosfamide-based Regimen May 2012 March 2016
NCT03283696 Completed Phase 1 A Study of Olaratumab (LY3012207), Doxorubicin, and Ifosfamide in Participants With Advanced or Metastatic Soft Tissue Sarcoma October 18, 2017 August 25, 2019
NCT01514188 Completed Phase 2 Preliminary Efficacy and Safety of INNO-206 Compared to Doxorubicin in Advanced Soft Tissue Sarcoma January 11, 2012 December 15, 2014
NCT01523977 Completed Phase 1 Everolimus With Multiagent Re-Induction Chemotherapy in Pediatric Patients With ALL November 2011 November 2018
NCT01537029 Completed Phase 4 Effect of Weight on the Population Pharmacokinetic Analysis of Doxorubicin and Cyclophosphamide February 2012 December 2016
NCT03248427 Completed Phase 2 Neadjuvant Multi-agent Chemotherapy or Letrozole Plus Ribociclib in Luminal B/HER2-negative Breast Cancer. July 13, 2017 July 20, 2019
NCT01569204 Completed Phase 2 Targeted BEACOPP Variants in Patients With Newly Diagnosed Advanced Classical Hodgkin Lymphoma October 2012 December 2017
NCT01593020 Completed Phase 2 Neoadjuvant Study of Sequential Eribulin Followed by FAC Compared to Sequential Paclitaxel Followed by FEC in Early Stage Breast Cancer Not Overexpressing HER-2 August 3, 2012 November 4, 2020
NCT01605526 Completed Phase 1 A Study of RO5045337 in Combination With Doxorubicin in Patients With Soft Tissue Sarcoma May 2012 June 2013
NCT01622439 Completed Phase 1/Phase 2 Valproate as First Line Therapy in Combination With Rituximab and CHOP in Diffuse Large B-cell Lymphoma June 2012 March 2018
NCT03197935 Completed Phase 3 A Study to Investigate Atezolizumab and Chemotherapy Compared With Placebo and Chemotherapy in the Neoadjuvant Setting in Participants With Early Stage Triple Negative Breast Cancer July 24, 2017 September 28, 2022
NCT01678664 Completed Phase 2 Everolimus After (Chemo)Embolization for Liver Metastases From Digestive Endocrine Tumors October 2012 April 2019
NCT01705691 Completed Phase 2 Comparison of Neoadjuvant Chemotherapy With Weekly Paclitaxel or Eribulin Followed by A/C in Women With Locally Advanced HER2-Negative Breast Cancer September 2012 October 2015
NCT01760226 Completed Early Phase 1 Dose Adjusted EPOCH-R, to Treat Mature B Cell Malignancies January 2013 December 2016
NCT01767155 Completed Phase 3 Zoptarelin Doxorubicin (AEZS 108) as Second Line Therapy for Endometrial Cancer April 2013 January 30, 2017
NCT01777152 Completed Phase 3 ECHELON-2: A Comparison of Brentuximab Vedotin and CHP With Standard-of-care CHOP in the Treatment of Patients With CD30-positive Mature T-cell Lymphomas January 31, 2013 October 2, 2020
NCT03056001 Completed Phase 2 Safety, Tolerability, and Efficacy of Doxorubicin and Pembrolizumab for Sarcoma May 1, 2017 November 15, 2022
NCT01818063 Completed Phase 2 Carboplatin and Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IIB-IIIC Breast Cancer April 25, 2013 December 10, 2018
NCT01847001 Completed Phase 2 Study of Propranolol in Newly Diagnosed Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy October 2012 October 16, 2019
NCT01848132 Completed Phase 2 Efficacy/Safety Study of R-CHOP vs Bortezomib-R-CAP for Young Patients With Diffuse Large B-cell Lymphoma With Poor IPI. October 3, 2013 August 2018
NCT01849783 Completed Phase 2 Autologous Stem Cell Transplant Followed By Maintenance Therapy in Treating Elderly Patients With Multiple Myeloma April 4, 2013 September 30, 2020
NCT01851733 Completed Phase 1 MRI-Guided Laser Surgery and Doxorubicin Hydrochloride in Treating Patients With Recurrent Glioblastoma Multiforme August 13, 2013 May 30, 2018
NCT01855750 Completed Phase 3 A Study of the Bruton's Tyrosine Kinase Inhibitor, PCI-32765 (Ibrutinib), in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With Newly Diagnosed Non-Germinal Center B-Cell Subtype of Diffuse Large B-Cell Lymphoma September 3, 2013 April 5, 2019
NCT03042819 Completed Phase 1 Study of Selinexor and Doxorubicin in Advanced Soft Tissue Sarcomas May 16, 2017 June 30, 2021
NCT01861951 Completed Phase 2 A Trial Comparing Two Medications as First Treatment in Elderly Patients With Metastatic or Advanced Soft Tissue Sarcoma October 2012 July 11, 2017
NCT01882816 Completed Phase 2 Intensity-Modulated Radiation Therapy (IMRT) in the Treatment of Non-Anaplastic Non-Medullary Thyroid Cancer June 13, 2013 November 4, 2021
NCT03023046 Completed Phase 2 Etoposide, Prednisone, Vincristine Sulfate, Cyclophosphamide, and Doxorubicin in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma February 23, 2017 May 1, 2022
NCT01889069 Completed Phase 3 A Study to Evaluate Safety, Efficacy and Pharmacokinetics of Rituximab (MabThera/Rituxan) in Participants With Diffuse Large B Cell Lymphoma (DLBCL) or Follicular Lymphoma (FL) July 31, 2013 May 28, 2019
NCT01940497 Completed Phase 3 A Study of the Safety of Subcutaneously Administered Trastuzumab (Herceptin) in Participants With Early and Locally Advanced Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer November 15, 2013 March 27, 2018
NCT01959490 Completed Phase 2 Trastuzumab and Pertuzumab or Bevacizumab With Combination Chemotherapy in Treating Patients With Stage II-III Breast Cancer September 24, 2013 March 29, 2017
NCT01964391 Completed Phase 3 A Study of Participant Satisfaction and Safety With Subcutaneously Administered Trastuzumab (Herceptin) in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Early Breast Cancer February 21, 2014 November 25, 2018
NCT03003520 Completed Phase 2 A Study of Durvalumab in Combination With R-CHOP or Lenalidomide Plus R-CHOP in Previously Untreated High-Risk Diffuse Large B-Cell Lymphoma February 28, 2017 April 24, 2022
NCT01966471 Completed Phase 3 A Study of Trastuzumab Emtansine (Kadcyla) Plus Pertuzumab (Perjeta) Following Anthracyclines in Comparison With Trastuzumab (Herceptin) Plus Pertuzumab and a Taxane Following Anthracyclines as Adjuvant Therapy in Participants With Operable HER2-Positive Primary Breast Cancer January 31, 2014 June 4, 2021
NCT01970540 Completed Phase 1 Study Escalating Doses of PM01183 in Combination With Fixed Doxorubicin in Patients With Specific Advanced Unresectable Solid Tumors May 25, 2011 August 9, 2017
NCT01974440 Completed Phase 3 A Study of PCI-32765 (Ibrutinib) in Combination With Either Bendamustine and Rituximab or Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Participants With Previously Treated Indolent Non-Hodgkin Lymphoma January 31, 2014 June 21, 2023
NCT01992653 Completed Phase 1/Phase 2 A Study of Polatuzumab Vedotin in Combination With Rituximab or Obinutuzumab, Cyclophosphamide, Doxorubicin, and Prednisone in Participants With B-Cell Non-Hodgkin's Lymphoma November 29, 2013 December 19, 2018
NCT01998906 Completed Phase 3 A Study of Herceptin (Trastuzumab) in Combination Chemotherapy in Women With Locally Advanced Breast Cancer May 2002 July 2012
NCT02032277 Completed Phase 3 A Study Evaluating Safety and Efficacy of the Addition of ABT-888 Plus Carboplatin Versus the Addition of Carboplatin to Standard Chemotherapy Versus Standard Chemotherapy in Subjects With Early Stage Triple Negative Breast Cancer April 2, 2014 November 12, 2020
NCT03000036 Completed N/A Doxorubicin-associated Cardiac Remodeling Followed by CMR in Breast Cancer Patients July 2012 July 2016
NCT02055820 Completed Phase 1/Phase 2 A Study Evaluating the Safety, Efficacy and Pharmacokinetics of Venetoclax Combined With Chemotherapy in Participants With B-Cell Non-Hodgkin's Lymphoma (NHL) and DLBCL November 17, 2013 June 28, 2019
NCT02076620 Completed Phase 1 L19TNFα in Combination With Doxorubicin in Patients With Advanced Solid Tumours January 16, 2013 January 25, 2018
NCT02997358 Completed Phase 3 Study Comparing Efficacy of Doxorubicin With Trabectedin Followed by Trabectedin Versus Doxorubicine in Patients With Leiomyosarcoma January 18, 2017 July 28, 2021
NCT02131480 Completed Phase 2 Study of Doxorubicin and Trabectedin in First Line Treatment on Patients With Metastatic Leiomyosarcoma June 2010 October 2016
NCT02132949 Completed Phase 2 A Study Evaluating Pertuzumab (Perjeta) Combined With Trastuzumab (Herceptin) and Standard Anthracycline-based Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Locally Advanced, Inflammatory, or Early-stage Breast Cancer July 14, 2014 August 25, 2020
NCT02177695 Completed Phase 2 S1314, Co-expression Extrapolation (COXEN) Program to Predict Chemotherapy Response in Patients With Bladder Cancer August 28, 2014 December 1, 2022
NCT02181738 Completed Phase 2 Study of Nivolumab in Patients With Classical Hodgkin's Lymphoma (Registrational) August 12, 2014 December 27, 2022
NCT02978495 Completed Phase 2 Neoadjuvant Carboplatin in Triple Negative Breast Cancer May 17, 2017 October 22, 2021
NCT02228772 Completed Phase 1 Phase I Study of MLN 9708 in Addition to Chemotherapy for the Treatment of Acute Lymphoblastic Leukemia in Older Adults December 2014 November 2019
NCT02229084 Completed Phase 1/Phase 2 Vaccination of High Risk Breast Cancer Patients January 14, 2015 January 3, 2023
NCT02285062 Completed Phase 3 Efficacy and Safety Study of Lenalidomide Plus R-CHOP Chemotherapy Versus Placebo Plus R-CHOP Chemotherapy in Untreated ABC Type Diffuse Large B-cell Lymphoma February 17, 2015 July 28, 2022
NCT02292979 Completed Phase 2 Brentuximab Vedotin Associated With Chemotherapy in Untreated Patients With Hodgkin Lymphoma. March 2015 June 2, 2022
NCT02326025 Completed Phase 1 A Study of Olaratumab and Doxorubicin in Participants With Advanced Soft Tissue Sarcoma January 22, 2015 November 2, 2018
NCT02348216 Completed Phase 1/Phase 2 Study Evaluating the Safety and Efficacy of KTE-C19 in Adult Participants With Refractory Aggressive Non-Hodgkin Lymphoma April 21, 2015 July 27, 2023
NCT02861222 Completed Phase 1 Myocet® in Children With Relapsed or Refractory Non-brainstem Malignant Glioma October 2010 April 2013
NCT02377752 Completed Phase 1 A Study of Olaratumab in Japanese Participants With Advanced Cancer March 23, 2015 January 14, 2020
NCT02786719 Completed N/A High-Risk Neuroblastoma Chemotherapy Without G-CSF June 2016 February 5, 2019
NCT02398240 Completed Phase 2 Brentuximab for Newly Diagnosed Hodgkin Disease May 2015 December 2022
NCT02406092 Completed Phase 3 Safety Study of Rituximab (SC) Administered in Participants With CD20+ DLBCL or CD20+ Follicular NHL Grade 1 to 3A October 13, 2015 June 30, 2021
NCT02412670 Completed Phase 2 Chemotherapy Before Surgery in Treating Patients With High Grade Upper Urinary Tract Cancer August 27, 2015 May 10, 2022
NCT02413320 Completed Phase 2 Neoadjuvant Study of Two Platinum Regimens in Triple Negative Breast Cancer July 2015 February 1, 2020
NCT02414568 Completed Phase 2 Bendamustine Study in Classical Hodgkin Lymphoma Patients Over 60 Treated by Prednisone, Vinblastine and Doxorubicin July 17, 2015 November 10, 2020
NCT02783599 Completed Phase 1 A Study of Olaratumab (LY3012207) in Participants With Soft Tissue Sarcoma October 11, 2016 July 5, 2018
NCT02419742 Completed Phase 4 Safety and Efficacy of Trastuzumab as Part of Breast Cancer Treatment Regimen August 18, 2015 June 24, 2021
NCT02448537 Completed Phase 2 A Phase II Multi-Strata Study of PM01183 as a Single Agent or in Combination With Conventional Chemotherapy in Metastatic and/or Unresectable Sarcomas August 2015 April 1, 2019
NCT02677116 Completed Phase 1 A Study of Olaratumab Alone and in Combination With Standard Chemotherapies in Children With Cancer August 29, 2016 April 3, 2019
NCT02670616 Completed Phase 2 Study of Ibrutinib in Combination With Rituximab-CHOP in Epstein-Barr Virus-positive Diffuse Large B-cell Lymphoma May 1, 2016 October 2020
NCT01358071 Completed Phase 2 Phase II Study of NGR-hTNF in Combination With Doxorubicin in Platinum-resistant Ovarian Cancer June 2011 December 2016
NCT00001498 Completed Phase 2 A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With Peripheral Blood Progenitor Cell Support, and Intensification With Paclitaxel and Doxorubicin for Patients With High-Risk Breast Cancer February 1996 December 2000
NCT00002707 Completed Phase 3 Chemotherapy in Treating Women With Breast Cancer That Can Be Surgically Removed December 1995 February 2010
NCT00003389 Completed Phase 3 Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma June 17, 1999 May 2016
NCT00003782 Completed Phase 3 Combination Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA (cT1-3, N0-1, M0) Breast Cancer and Positive Axillary Lymph Nodes March 1999 December 2012
NCT00003907 Completed Phase 2 Chemoembolization in Treating Patients With Primary Liver Cancer or Metastases to the Liver December 15, 1999 August 2012
NCT00005800 Completed Phase 2 Doxorubicin and Docetaxel in Treating Women With Stage III Breast Cancer April 1999 May 2012
NCT00016406 Completed Phase 3 S0012 Doxorubicin, Cyclophosphamide, and Paclitaxel With or Without Filgrastim in Treating Women With Inflammatory or Locally Advanced Breast Cancer May 2001 February 2012
NCT00001300 Completed Phase 3 A Randomized Study of the Effect of Adjuvant Chemotherapy With Doxorubicin and Ifosfamide With Mesna in the Treatment of High-Grade Adult Extremity Soft Tissue Sarcoma June 1992 March 2001
NCT00021255 Completed Phase 3 Combination Chemotherapy With or Without Trastuzumab in Treating Women With Breast Cancer April 2001 December 2014
NCT00026208 Completed Phase 2 Combination Chemotherapy Plus Low-Dose Radiation Therapy in Treating Patients With Stage I or Stage IIA Hodgkin's Lymphoma June 2001 February 13, 2017
NCT06313047 Completed Pharmacogenetic of Doxorubicin in HCC. January 1, 2021 December 30, 2023
NCT00038610 Completed Phase 2 Study of Hyper-CVAD Plus Imatinib Mesylate for Philadelphia-Positive Acute Lymphocytic Leukemia March 2001 July 2014
NCT00041132 Completed Phase 2 S0213 Chemotherapy Plus Rituximab in Treating Patients With Mantle Cell Lymphoma September 2002 June 2011
NCT00051311 Completed Phase 2 Modified Stem Cell Transplant Procedure to Treat Patients With Blood and Immune System Cancers January 3, 2003 September 25, 2014
NCT00054665 Completed Phase 2 PS-341 Alone and PS-341 Plus EPOCH Chemotherapy to Treat Non-Hodgkin's Lymphoma February 2003 July 2009
NCT00068393 Completed Phase 2 Doxorubicin and Gemcitabine in Treating Patients With Locally Recurrent or Metastatic Unresectable Renal Cell Carcinoma February 24, 2004 May 2011
NCT00083226 Completed Phase 2 Doxorubicin and Bortezomib in Treating Patients With Liver Cancer March 2004 August 2012
NCT00083551 Completed Phase 3 UARK 98-026 TT II: Multiple Myeloma Evaluating Anti-Angiogenesis With Thalidomide and Post-Transplant Consolidation Chemotherapy August 1998 August 2014
NCT00093795 Completed Phase 3 Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Positive Breast Cancer October 2004 June 2016
NCT00094497 Completed Phase 3 Trial in Locally Advanced and Metastatic Adrenocortical Carcinoma Treatment (FIRM-ACT) June 2004 December 2010
NCT00101101 Completed Phase 2 Universal Granulocyte Macrophage-colony Stimulating Factor (GM-CSF)-Producing and GM.CD40L for Autologous Tumor Vaccine in Mantle Cell Lymphoma July 2004 June 14, 2021
NCT00102219 Completed Phase 2 A Study of Pemetrexed Plus Doxorubicin Given to Patients With Advanced Breast Cancer October 2004 October 2007
NCT00102609 Completed Phase 1 A Safety Study Utilizing Yondelis and Doxorubicin in Patients With a Type of Cancer Called Soft Tissue Sarcoma April 2005 October 2007
NCT00109837 Completed Phase 2 S0333 Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia April 2005 November 2014
NCT00115414 Completed Phase 2 Same Day Dosing of Pegfilgrastim in Breast Cancer Patients Undergoing Chemotherapy (TAC)
NCT00118209 Completed Phase 3 Rituximab and Combination Chemotherapy in Treating Patients With Diffuse Large B-Cell Non-Hodgkin's Lymphoma May 2005 November 15, 2021
NCT00121992 Completed Phase 3 Docetaxel, Doxorubicin (A), Cyclophosphamide (C) (TAC) vs 5-Fluorouracil, A, C (5FAC) Breast Cancer Adjuvant Treatment July 1999 March 6, 2013
NCT00123929 Completed Phase 2 Genetic Expression and Prediction of Response to Neoadjuvant Docetaxel or Doxorubicin in Locally Advanced Breast Cancer January 2005 May 2009
NCT05291338 Completed Pharmacogenetic Study in Hepatocellular Carcinoma Patients. January 1, 2022 April 1, 2023
NCT00129376 Completed Phase 2 Doxorubicin and Cyclophosphamide (AC) Followed by Weekly Docetaxel as Neoadjuvant Treatment of Breast Cancer Patients February 2003 February 2010
NCT00129389 Completed Phase 3 FAC Versus FAC Plus Weekly Paclitaxel as Adjuvant Treatment of Node Negative High Risk Breast Cancer Patients September 19, 2003 October 1, 2013
NCT00131963 Completed A Pharmacogenomics Study for Breast Cancer Patients Undergoing Adjuvant Chemotherapy With Doxorubicin (A)/Cyclophosphamide ©) and/or Weekly Paclitaxel October 2003 October 2014
NCT00136565 Completed Phase 2 Study of Bortezomib Combined With ACVBP in Peripheral T-cell Lymphoma January 8, 2006 April 18, 2011
NCT00140595 Completed Phase 3 ACVBP Plus Rituximab Versus CHOP Plus Rituximab in Patients With Diffuse Large B-cell Lymphoma and Age-adjusted IPI of 1 December 2003 January 2009
NCT00144807 Completed Phase 2 ACVBP Plus Rituximab in Patients Aged From 18 to 59 Years With High-risk Diffuse Large B-cell Lymphoma December 2003 April 2012
NCT00146562 Completed Phase 2 Pegfilgrastim and Darbepoetin Alfa in Support of Adjuvant Chemotherapy for Breast Cancer July 2003 May 2007
NCT00148681 Completed Phase 2 Preoperative Herceptin and Navelbine for Breast Cancer May 2001 May 2003
NCT00149214 Completed Phase 2 Preoperative Treatment of Breast Cancer With Two Different Sequential Treatment Regimens September 2005 March 2011
NCT00165178 Completed Phase 3 Treatment of Acute Lymphoblastic Leukemia in Children September 2000 May 2011
NCT00165191 Completed Phase 2 Doxorubicin, Cisplatin, 5-Fluorouracil in Patients With Advanced Adenocarcinoma of the Stomach or Esophagus August 1998 January 2006
NCT00169130 Completed Phase 2/Phase 3 ACVBP Followed by ASCT in Patients With BCL-2 Positive Diffuse Large B-Cell Lymphoma October 1999
NCT05112536 Completed Phase 2 Trilaciclib, a CDK4/6 Inhibitor, in Patients With Early-Stage Triple Negative Breast Cancer March 3, 2022 March 13, 2023
NCT00191789 Completed Phase 2 Neoadjuvant Sequential Administration of Two Gemcitabine Combinations in Operable Breast Cancer February 2003 April 2009
NCT00193115 Completed Phase 2 Docetaxel Followed by Doxorubicin Plus Cyclophosphamide for Node Positive or High-Risk Primary Breast Cancer March 2004 January 2009
NCT00194753 Completed Phase 2 Adjuvant Therapy for High-Risk Breast Cancer With Wkly Adriamycin & Oral Cytoxan With G-CSF for 12 Wks; Wkly Taxol x 12 December 2001 March 2011
NCT00201708 Completed Phase 2 Dose-Dense Docetaxel Before or After Doxorubicin/Cyclophosphamide in Axillary Node-Positive Breast Cancer October 2004 February 2014
NCT00206518 Completed Phase 2 Taxotere and Adriamycin/Cytoxan (AC) Validation in Breast Cancer Patients September 2004 October 10, 2016
NCT00211185 Completed Phase 2 A Study of ONTAK and CHOP in Newly Diagnosed, Peripheral T-Cell Lymphoma March 14, 2004 December 23, 2009
NCT00217425 Completed Phase 2 Bevacizumab and Combination Chemotherapy in Treating Patients With Peripheral T-Cell Lymphoma or Natural Killer Cell Neoplasms September 14, 2006 March 2014
NCT04933617 Completed Phase 1 Copanlisib With Dose-Adjusted EPOCH-R in Relapsed and Refractory Burkitt Lymphoma and Other High-Grade B-cell Lymphomas March 24, 2022 November 30, 2023
NCT00254592 Completed Phase 2 Neoadjuvant Treatment of Breast Cancer October 2005 September 4, 2013
NCT00256243 Completed Phase 2 Neoadjuvant Biweekly Treatment Followed by Weekly Treatment of Breast Cancer April 2004 July 2012
NCT00262990 Completed Phase 3 Patupilone Versus Doxorubicin in Patients With Ovarian, Primary Fallopian, or Peritoneal Cancer November 2005
NCT00278109 Completed Phase 1/Phase 2 Partial Breast Irradiation With Chemotherapy July 2004 December 2016
NCT00288431 Completed Phase 1 Safety, Tolerability and Maximum Tolerated Dose of Oral AP23573 in Combination With Doxorubicin (8669-015) February 2006 July 2008
NCT00290498 Completed Phase 2 Study of Rituximab-HCVAD Alternating With Rituximab-Methotrexate-Cytarabine Versus Standard Rituximab-CHOP Every 21 Days for Patients With Newly Diagnosed High Risk Aggressive B-Cell Non-Hodgkin's Lymphomas in Patients 60 Years Old or Younger August 1, 2005 August 11, 2017
NCT00299182 Completed Phase 1/Phase 2 Study of AMG 531 to Evaluate the Safety & Efficacy in Patients With Non-Hodgkin's Lymphoma March 2006 April 2012
NCT00305084 Completed Phase 1 Study of NGR-hTNF in Combination With Doxorubicin in Solid Tumors February 28, 2006 May 8, 2007
NCT00314977 Completed Phase 3 Sequential vs Upfront Intensified Neoadjuvant Chemotherapy in Patients With Large Resectable or Locally Advanced Breast Cancer. February 2006
NCT00336791 Completed Phase 3 Randomized Clinical Trial to Evaluate the Predictive Accuracy of a Gene Expression for Stage I-II Breast Cancer September 2003 September 2010
NCT04790903 Completed Phase 1 A Study Evaluating the Safety, Efficacy and Pharmacokinetics of Venetoclax in Combination With Polatuzumab Vedotin Plus Rituximab (R) and Cyclophosphamide, Doxorubicin, Prednisone (CHP) in Participants With Untreated BCL-2 Immunohistochemistry (IHC)-Positive Diffuse Large B-Cell Lymphoma (DLBCL) July 2, 2021 May 21, 2024
NCT00365417 Completed Phase 2 Therapy With Bevacizumab (BEV), Doxorubicin, and Cyclophosphamide Followed by BEV, Docetaxel, and Capecitabine Before Surgery Followed by BEV Alone After Surgery for Women With Locally Advanced Breast Cancer August 2006 November 2009
NCT00369681 Completed Phase 2 Phase 2 Study of Rituximab-ABVD in Classical Hodgkin Lymphoma May 2006 October 2014
NCT00379574 Completed Phase 1/Phase 2 Bortezomib Plus CHOP Every 2 Weeks for Advanced Stage DLBCL September 2006 January 2011
NCT00390793 Completed Phase 2 Combination Chemotherapy and Dasatinib in Treating Participants With Philadelphia Positive or BCR-ABL Positive Acute Lymphoblastic Leukemia. September 28, 2006 February 2, 2024
NCT00404066 Completed Phase 2 Phase 2 Neoadjuvant Doxorubicin and Cyclophosphamide -> Docetaxel With Lapatinib in Stage II/III Her2Neu+ Breast Cancer October 2006 March 2011
NCT04660799 Completed Phase 2 A Study on Pharmacokinetics (PK), Efficacy and Safety of Subcutaneous (SC) Versus Intravenous (IV) Rituximab, in Combination With CHOP (Cyclophosphamide, Doxorubicin, Vincristine, Prednisone) in Previously Untreated Participants With CD20 Positive Diffuse Large B-Cell Lymphoma (DLBCL) February 24, 2021 October 11, 2022
NCT00440726 Completed Phase 1/Phase 2 Bortezomib With Chemotherapy for Relapsed Pediatric Acute Lymphoblastic Leukemia (ALL) August 4, 2006 February 26, 2011
NCT00446030 Completed Phase 2 Pilot Study of the Safety & Efficacy of Two Docetaxel-Based Regimens Plus Bevacizumab for the Adjuvant Treatment of Subjects With Node Positive or High Risk Node Negative Breast Cancer March 2007 August 2010
NCT04584112 Completed Phase 1 A Study of the Safety, Efficacy, and Pharmacokinetics of Tiragolumab in Combination With Atezolizumab and Chemotherapy in Participants With Triple-Negative Breast Cancer September 28, 2020 March 8, 2023
NCT00450801 Completed Phase 2 R-MACLO-IVAM and Thalidomide in Untreated Mantle Cell Lymphoma April 2004 July 2015
NCT00451178 Completed Phase 2 A Study of Participants With Lymphoma Who Take R-CHOP and Enzastaurin Compared to Participants Who Take R-CHOP Only May 2007 January 2013
NCT00455533 Completed Phase 2 Study to Assess Effectiveness of Giving Combination of Standard Chemotherapy Drugs Versus Combination of Standard Chemotherapy and New Drug Ixabepilone When Given Before Surgical Removal of Early Stage Breast Cancer October 2007 December 2009
NCT00470301 Completed Phase 1/Phase 2 Tipifarnib and Combination Chemotherapy in Treating Patients With Stage II or Stage III Breast Cancer April 2007 September 2013
NCT02529852 Completed Phase 1/Phase 2 A Phase I/II Study of Lenalidomide and Obinutuzumab With CHOP for Diffuse Large B Cell Lymphoma November 4, 2015 October 31, 2022
NCT02617485 Completed Phase 3 MabionCD20 Compared to MabThera in Lymphoma Patients December 2015 January 2018
NCT02483247 Completed Phase 1 A Study of BBI503 in Combination With Selected Anti-Cancer Therapeutics in Adult Patients With Advanced Cancer September 2015 May 2019
NCT02605915 Completed Phase 1 Safety and Pharmacokinetics of Atezolizumab Combination Treatments in Participants With HER2-Positive and HER2-Negative Breast Cancer December 31, 2015 November 13, 2019
NCT02596971 Completed Phase 1/Phase 2 A Study of Atezolizumab in Combination With Either Obinutuzumab Plus Bendamustine or Obinutuzumab Plus (+) Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Participants With Follicular Lymphoma (FL) or Rituximab + CHOP in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) December 22, 2015 May 8, 2020
NCT06201507 Enrolling by invitation Phase 2 BV-AVD-R Treatment Children Hodgkin's Lymphoma October 1, 2022 December 31, 2025
NCT06441097 Not yet recruiting Phase 2 Efficacy of Pola-RCHP-X vs Pola-RCHP in Untreated DLBCL December 31, 2024 December 31, 2027
NCT03892330 Not yet recruiting Phase 4 Combination Therapy of Anthracyclines for Children With Nephroblastoma June 1, 2019 June 30, 2045
NCT04199026 Not yet recruiting Early Phase 1 Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent Sarcoma January 31, 2025 December 31, 2025
NCT05006664 Not yet recruiting Phase 2 Brentuximab Vedotin in Combination With CHEP in Patient With PTCL October 2021 October 2024
NCT05287308 Not yet recruiting N/A Adjuvant Albumin-bound Paclitaxel Versus Taxanes in Breast Cancer: a Real-world Study March 2022 September 2027
NCT05872412 Not yet recruiting Phase 2 Effect of Platinum-based Versus Non-platinum-based Neoadjuvant Chemotherapy in Triple-negative Breast Cancer June 1, 2023 April 30, 2024
NCT06023862 Not yet recruiting Phase 2 A Three-arm Randomized Phase II Study of Dostarlimab Alone or With Bevacizumab Versus Nonplatinum Chemotherapy in Recurrent Gynecological Clear Cell Carcinoma: DOVE (APGOT-OV7/ ENGOT-ov80 Study) January 22, 2024 December 31, 2029
NCT06124157 Not yet recruiting Phase 3 A Study Comparing the Combination of Dasatinib and Chemotherapy Treatment With or Without Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or Philadelphia Chromosome-Like (Ph-Like) ABL-Class B-Cell Acute Lymphoblastic Leukemia (B-ALL) July 22, 2024 December 1, 2030
NCT06220032 Not yet recruiting Phase 3 Prevention of Anthracycline-Induced Cardiac Dysfunction With Dexrazoxane in Patients With Diffuse Large-B Cell Lymphoma May 21, 2024 December 15, 2028
NCT06249191 Not yet recruiting Phase 1/Phase 2 Mosunetuzumab With Chemotherapy for the Treatment of Patients With Untreated C-Myc Rearrangement Positive High Grade B Cell Lymphoma or Diffuse Large B Cell Lymphoma May 31, 2024 April 1, 2027
NCT06277154 Not yet recruiting Phase 2 MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma February 2024 February 2027
NCT06295094 Not yet recruiting Phase 2 The Efficacy of PIPAC and Minimally Invasive Radical Resection in High-risk Gastric Cancer Patients. September 2024 January 2028
NCT06313996 Not yet recruiting Phase 3 A Study to Evaluate the Efficacy and Safety of Liso-cel Compared to Standard of Care in Adults With Relapsed or Refractory Follicular Lymphoma March 29, 2024 October 16, 2031
NCT06317662 Not yet recruiting Phase 2 Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia July 31, 2024 December 21, 2027
NCT06340568 Not yet recruiting Phase 3 A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer August 2024 December 2028
NCT06394492 Not yet recruiting Phase 3 SHR-A1921 for Injection in Patients With Platinum-Resistant Recurrent Epithelial Ovarian Cancer May 31, 2024 December 31, 2026
NCT06401330 Not yet recruiting Phase 3 A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT) June 12, 2024 February 13, 2031
NCT06404463 Not yet recruiting Phase 2 QL1706 Plus Chemotherapy as Neoadjuvant Therapy in Early High-Risk ER+/HER2- Breast Cancer May 6, 2024 November 6, 2030
NCT06422806 Not yet recruiting Phase 2 Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas June 14, 2024 June 30, 2026
NCT06425302 Not yet recruiting Phase 2 A Study to Evaluate the Efficacy and Safety of Golcadomide in Combination With Rituximab in Participants With Newly Diagnosed Advanced Stage Follicular Lymphoma August 3, 2024 November 27, 2028
NCT05389423 Recruiting Phase 1 Pomalidomide and Dose-Adjusted EPOCH +/- Rituximab for HIV-Associated Lymphomas June 27, 2023 June 1, 2032
NCT05371093 Recruiting Phase 3 Study of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Follicular Lymphoma September 12, 2022 October 2030
NCT05959720 Recruiting Adult Acute Lymphoblastic Leukemia Treated With Pediatric Regimen in Brazil September 5, 2023 June 2030
NCT02797717 Recruiting N/A Treatment for Classical Hodgkin Lymphoma in Children and Adolescents November 2015 December 2027
NCT06239272 Recruiting Phase 1/Phase 2 NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) March 27, 2024 June 2037
NCT04139304 Recruiting Early Phase 1 A Study of Daratumumab and Dose-Adjusted EPOCH in Plasmablastic Lymphoma May 24, 2021 August 2027
NCT05351346 Recruiting Phase 3 Genotype-guided Treatment in DLBCL June 1, 2022 June 1, 2026
NCT06251180 Recruiting Phase 1 Phase Ib Study of Rocbrutinib in Combination With R-CHOP in Patients With Newly Diagnosed B-cell Non-Hodgkin Lymphoma April 10, 2024 December 31, 2029
NCT04203641 Recruiting Phase 1/Phase 2 L-DOS47 Plus Doxorubicin in Advanced Pancreatic Cancer December 11, 2019 August 31, 2025
NCT04213794 Recruiting Early Phase 1 Heated Intra-peritoneal Chemotherapy With Doxorubicin and Cisplatin for Abdominal for Pelvic Tumors in Pediatric Patients November 8, 2019 January 30, 2025
NCT04216524 Recruiting Phase 2 Venetoclax, SL-401, and Chemotherapy for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm May 29, 2020 December 31, 2026
NCT04221035 Recruiting Phase 3 High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN) November 5, 2019 November 2032
NCT01704716 Recruiting Phase 3 High Risk Neuroblastoma Study 1.8 of SIOP-Europe (SIOPEN) February 2002 September 2026
NCT05404945 Recruiting Phase 2 Fitness-adapted, Pembrolizumab-based Therapy for Untreated Classical Hodgkin Lymphoma Patients 60 Years of Age and Above July 26, 2022 October 3, 2027
NCT04043494 Recruiting Phase 3 International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma August 23, 2019 November 22, 2027
NCT04243616 Recruiting Phase 2 Cemiplimab in High Risk or Locally Advanced Hormone Receptor Positive HER2 Negative or Triple-Negative Breast Cancer March 5, 2020 January 1, 2026
NCT02811523 Recruiting Phase 1 In Vivo Lung Perfusion for Pulmonary Metastases of Sarcoma February 2016 February 2025
NCT04322318 Recruiting Phase 2 A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT October 19, 2020 July 1, 2027
NCT04329494 Recruiting Phase 1 PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer August 21, 2020 December 30, 2025
NCT04383743 Recruiting Phase 2 Pembrolizumab and Combination Chemotherapy Before Surgery for the Treatment of Muscle-Invasive Bladder Cancer November 24, 2020 October 28, 2025
NCT04423926 Recruiting Phase 1/Phase 2 Lenalidomide in Combination With CHOP in Patients With Untreated PTCL June 10, 2020 December 31, 2024
NCT04432714 Recruiting Phase 1/Phase 2 Lenalidomide in Combination With R-DA-EPOCH in Patients With Untreated DLBCL With MYC Rearrangement June 9, 2020 December 31, 2026
NCT04443348 Recruiting Phase 2 Pre-op Pembro + Radiation Therapy in Breast Cancer (P-RAD) December 16, 2020 December 2024
NCT05303792 Recruiting Phase 2 Testing the Combination of Inotuzumab Ozogamicin and Lower Dose Chemotherapy Compared to Usual Chemotherapy for Adults With B-Cell Acute Lymphoblastic Leukemia or B-Cell Lymphoblastic Lymphoma February 27, 2023 May 2028
NCT05292664 Recruiting Phase 1 Venetoclax Basket Trial for High Risk Hematologic Malignancies March 29, 2023 April 2, 2027
NCT06377566 Recruiting Phase 2 A Study of BV-AVD in People With Bulky Hodgkin Lymphoma April 17, 2024 April 2027
NCT04535713 Recruiting Phase 2 GALLANT: Metronomic Gemcitabine, Doxorubicin, Docetaxel and Nivolumab for Advanced Sarcoma September 30, 2020 December 31, 2025
NCT05929768 Recruiting Phase 3 Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer September 15, 2023 April 2033
NCT03277924 Recruiting Phase 1/Phase 2 Trial of Sunitinib and/or Nivolumab Plus Chemotherapy in Advanced Soft Tissue and Bone Sarcomas May 31, 2017 June 30, 2025
NCT04594798 Recruiting Phase 2 A Study of Polatuzumab Vedotin, Rituximab and Dose Attenuated CHP in Older Patients With DLBCL September 20, 2021 July 31, 2024
NCT04625907 Recruiting Phase 1/Phase 2 FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma September 17, 2020 June 2030
NCT04638790 Recruiting Phase 3 First Line Chemotherapy for Classical Hodgkin Lymphoma in Russia (HL-Russia-1) February 1, 2020 December 31, 2026
NCT06284122 Recruiting Phase 3 Study of Mosunetuzumab Plus Lenalidomide Compared to Anti-CD20 Anti-body + Chemotherapy in Follicular Lymphoma FLIPI2-5 May 2024 April 2034
NCT04650984 Recruiting Phase 3 A Study Comparing the Efficacy of L19TNF+Doxorubicin vs Doxorubicin Alone as First-line Therapy in Patients With Advanced or Metastatic Soft Tissue Sarcoma November 29, 2017 December 31, 2025
NCT05270057 Recruiting Phase 1 Loncastuximab Tesirine in Combination With DA-EPOCH-R in Patients With Previously Untreated Aggressive B-cell Lymphoid Malignancies January 26, 2023 May 2026
NCT06191744 Recruiting Phase 3 Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma February 5, 2024 May 18, 2037
NCT04685616 Recruiting Phase 3 Brentuximab Vedotin in Early Stage Hodgkin Lymphoma April 14, 2022 September 2032
NCT04745949 Recruiting Phase 2 PACIFIC: Primary Mediastinal Large B-cell Lymphoma Treated With Antibody Therapy, Checkpoint Inhibitor in Frontline With ImmunoChemotherapy May 10, 2021 August 3, 2025
NCT04757337 Recruiting Phase 3 Comparison of Oral Cyclophosphamide vs Doxorubicin in ≥65 Years Old Advanced or Metastatic Soft Tissue Sarcoma Patients June 18, 2021 April 2026
NCT05200312 Recruiting Phase 2 A Phase II Study of Zanubrutinib, Lenalidomide Plus R-CHOP as the First-line Treatment for Diffused Large B-cell Lymphoma February 1, 2022 February 1, 2025
NCT04776525 Recruiting Phase 2 Sequential Neoadjuvant Chemotherapy in Soft Tissue Sarcoma April 27, 2021 September 2036
NCT05899621 Recruiting A Real-world Study of Obinutuzumab-based Therapy for Previously Untreated FL June 1, 2023 June 30, 2027
NCT05848765 Recruiting Phase 2 Relapsed Follicular Lymphoma Randomised Trial Against Standard ChemoTherapy September 4, 2023 November 30, 2031
NCT04803201 Recruiting Phase 2 Testing the Addition of Duvelisib or CC-486 to the Usual Treatment for Peripheral T-Cell Lymphoma July 30, 2021 January 1, 2026
NCT05099666 Recruiting Phase 1/Phase 2 Lurbinectedin + Doxorubicin In Leiomyosarcoma February 4, 2022 July 2025
NCT04835870 Recruiting Phase 2 Zanubrutinib Plus R-CHOP for Patients With Newly Diagnosed Untreated Non-GCB DLBCL April 1, 2021 October 1, 2025
NCT04847063 Recruiting Phase 1 Individualized Response Assessment to Heated Intraperitoneal Chemotherapy (HIPEC) for the Treatment of Peritoneal Carcinomatosis From Ovarian, Colorectal, Appendiceal, or Peritoneal Mesothelioma Histologies October 19, 2021 December 30, 2031
NCT05088057 Recruiting Phase 2 Neoadjuvant Camrelizumab Plus Chemotherapy in Triple Negative Breast Cancer September 20, 2021 November 1, 2024
NCT04874311 Recruiting Phase 2 Bintrafusp Alfa and Doxorubicin Hydrochloride in Treating Patients With Advanced Sarcoma March 1, 2022 March 2025
NCT04884035 Recruiting Phase 1 Study of Safety and Efficacy of Iberdomide (CC-220) and CC-99282 Combined With R-CHOP to Treat Lymphoma September 15, 2021 February 4, 2026
NCT05809830 Recruiting Phase 1/Phase 2 Phase I/II of LB-100 Plus Doxorubicin vs. Doxorubicin Alone in First Line of Advanced Soft Tissue Sarcomas May 29, 2023 May 8, 2026
NCT04922567 Recruiting Phase 2 Efficacy and Safety of Lenalidomide Plus CHOP vs CHOP in Patients With Untreated Peripheral T-Cell Lymphoma April 1, 2021 December 31, 2026
NCT06172296 Recruiting Phase 3 Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma April 19, 2024 December 31, 2029
NCT04947501 Recruiting Early Phase 1 A Study of N9 Chemotherapy in Children With Neuroblastoma June 22, 2021 June 22, 2025
NCT04968106 Recruiting Phase 2 Neoadjuvant Chemotherapy and Retifanlimab in Patients With Selected Sarcomas (TORNADO) December 7, 2022 October 2027
NCT05020860 Recruiting Phase 2 Correlation of Clinical Response to Pathologic Response in Patients With Early Breast Cancer April 18, 2023 November 2029
NCT06336395 Recruiting Phase 2 Ma-Spore ALL 2020 Study March 4, 2020 March 2030
NCT05774275 Recruiting Phase 1/Phase 2 The Combination of Radiotherapy, Chemotherapy and Immunotherapy in High-Risk Localized Soft Tissue Sarcoma August 25, 2022 August 24, 2029
NCT04996160 Recruiting Phase 1 Palbociclib in Combination With Chemotherapy in Pediatric Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia (RELPALL2) July 9, 2021 December 2025
NCT02449265 Recruiting Phase 3 Efficacy of Consolidative Involved-site Radiotherapy for Patients With Limited-stage Diffuse Large B-cell Lymphoma October 2015 October 2025
NCT03360760 Recruiting N/A Timing of Surgery in Nonmetastatic Osteosarcoma of the Pelvis and Sacrum August 1, 2018 February 2025
NCT05766605 Recruiting Phase 3 Applicability of PDOX in Patients With Primary Liver Cancer: A Randomized Controlled Trial January 1, 2023 January 30, 2026
NCT02853500 Recruiting N/A Effect of Surefire Infusion Device on Tumor Response to Regional Intra-arterial Therapy for Primary Liver Malignancies July 2016 July 2027
NCT03412643 Recruiting Phase 2 Study of Neoadjuvant Chemotherapy Plus Trastuzumab and Pertuzumab in HER2-Negative Breast Cancer Patients With Abnormal HER2 Signaling May 14, 2018 October 30, 2023
NCT03420014 Recruiting Phase 2 Treatment of Metastatic Soft Tissue Sarcoma (STS) Patients (FIBROSARC USA) December 27, 2018 December 2025
NCT05701436 Recruiting Phase 3 Applicability of 3D-HDRA in Patients With Primary Liver Cancer: A Randomized Controlled Trial September 1, 2022 March 1, 2026
NCT06164275 Recruiting Phase 2 Pembrolizumab Followed by Chemotherapy for the Treatment of Patients With Classical Hodgkin Lymphoma February 6, 2024 December 31, 2031
NCT06155331 Recruiting Phase 4 Evaluation of Possible Safety and Efficacy of Fenofibrate in the Prophylaxis of Doxorubicin Induced Cardiotoxicity in Breast Cancer Patients December 2023 December 2025
NCT05673785 Recruiting Phase 2 A Study of Brentuximab Vedotin in Combination With Cyclophosphamide, Doxorubicin (Hydroxydaunorubicin), Prednisone (CHP) in Chinese Participants With CD30-Positive (CD30+) Peripheral T-Cell Lymphomas (PTCL) February 10, 2023 December 31, 2027
NCT06132958 Recruiting Phase 3 Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005) December 6, 2023 January 10, 2028
NCT05661201 Recruiting Phase 1 NEROFE and Doxorubicin in KRAS-mutated ST2-positive Solid Tumors April 12, 2023 January 2026
NCT06356129 Recruiting Phase 3 Study to Compare the Effectiveness and Safety of Golcadomide Plus R-CHOP vs Placebo Plus R-CHOP in Participants With Previously Untreated High-risk Large B-cell Lymphoma June 24, 2024 November 20, 2029
NCT02449252 Recruiting Phase 3 Efficacy of Consolidative Involved-site Radiotherapy for Patients With Limited-stage Follicular Lymphoma October 2015 October 2025
NCT05645380 Recruiting Phase 2 Neoadjuvant TIL- and Response-Adapted Chemoimmunotherapy for TNBC December 5, 2022 December 2025
NCT05630209 Recruiting Phase 1/Phase 2 Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG January 4, 2023 January 2026
NCT03571321 Recruiting Phase 1 Ruxolitinib and Chemotherapy in Adolescents and Young Adults With Ph-like Acute Lymphoblastic Leukemia May 28, 2019 September 5, 2027
NCT06121570 Recruiting Phase 1 Phase I Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes as Neoadjuvant Therapy for HER2-Negative Breast Cancer November 1, 2023 August 31, 2031
NCT03007147 Recruiting Phase 3 Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia August 8, 2017 September 30, 2027
NCT05615623 Recruiting Phase 1/Phase 2 Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG January 4, 2023 July 4, 2025
NCT05605899 Recruiting Phase 3 Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma February 10, 2023 March 2031
NCT03643276 Recruiting Phase 3 Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017 July 15, 2018 July 14, 2028
NCT02449278 Recruiting Phase 3 The Palliative Benefit of Involved-site Radiotherapy for Patients With Advanced-stage Diffuse Large B-cell Lymphoma October 2015 October 2025
NCT06112379 Recruiting Phase 3 A Phase III Randomised Study to Evaluate Dato-DXd and Durvalumab for Neoadjuvant/Adjuvant Treatment of Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer November 14, 2023 August 28, 2030
NCT06097364 Recruiting Phase 3 A Study to Learn How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Compared to Rituximab and Chemotherapy in Adult Participants With Previously Untreated Follicular Lymphoma November 14, 2023 January 24, 2030
NCT02372409 Recruiting Phase 2 Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors August 14, 2015 August 31, 2030
NCT03719105 Recruiting Early Phase 1 Chemoimmunotherapy and Allogeneic Stem Cell Transplant for NK T-cell Leukemia/Lymphoma March 1, 2019 December 31, 2026
NCT05600686 Recruiting Phase 2 Loncastuximab Tesirine and Rituximab Followed by DA-EPOCH-R for Treating Patients With High-Risk Diffuse Large B-cell Lymphoma May 24, 2023 February 1, 2028
NCT05580887 Recruiting Intestinal Microbiota Impact for Prognosis and Treatment Outcomes in Early Luminal Breast Cancer and Pancreatic Cancer Patients May 12, 2022 August 2025
NCT05578976 Recruiting Phase 3 A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL) February 8, 2023 December 30, 2029
NCT03755804 Recruiting Phase 2 Pediatric Classical Hodgkin Lymphoma Consortium Study: cHOD17 December 12, 2018 July 1, 2028
NCT03758989 Recruiting Phase 2 A Study of PET Adapted Therapy and Non-invasive Monitoring for Previously Untreated Limited Stage Diffuse Large B Cell Lymphoma May 8, 2019 June 1, 2026
NCT03033914 Recruiting Phase 1/Phase 2 A(B)VD Followed by Nivolumab as Frontline Therapy for Higher Risk Patients With Classical Hodgkin Lymphoma (HL) January 25, 2017 January 2026
NCT06091865 Recruiting Phase 3 A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Patients With Previously Untreated Diffuse Large B-cell Lymphoma December 13, 2023 September 18, 2028
NCT06091254 Recruiting Phase 3 A Trial to Learn if Odronextamab is Safe and Well-tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Participants With Follicular Lymphoma December 12, 2023 April 3, 2029
NCT06318897 Recruiting Phase 2 Open-label, Single Center, Single-arm, Phase 2 Study of Neoadjuvant Pembrolizumab in Combination With Carboplatin and Paclitaxel in Patients With Stage 1 cT1b-T1cN0M0 Triple Negative Breast Cancer May 29, 2024 September 30, 2027
NCT03805022 Recruiting Phase 3 Benefit of Intensified Peri-operative Chemotherapy Within High-risk CINSARC Patients With Resectable Soft-tissue Sarcomas February 14, 2019 February 2025
NCT06088290 Recruiting Phase 2/Phase 3 Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma September 21, 2023 November 26, 2026
NCT05467670 Recruiting Phase 2 Safety and Efficacy of Anti-CD47, ALX148 in Combination With Liposomal Doxorubicin and Pembrolizumab in Recurrent Platinum-resistant Ovarian Cancer December 16, 2022 December 2027
NCT03837873 Recruiting Phase 2 DLCL002 Protocol for Patients With High Risk Aggressive B-cell Lymphoma January 21, 2019 September 1, 2024
NCT05455697 Recruiting Phase 1/Phase 2 Tafasitamab, Retifanlimab, and Rituximab in Combination With Standard Therapy for the Treatment of Diffuse Large B-cell Lymphoma January 26, 2023 July 6, 2026
NCT06245889 Recruiting Phase 2 PET Dynamics to Response-Adapted Neoadjuvant Therapy in TNBC May 1, 2024 June 2030
NCT06058377 Recruiting Phase 3 Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer November 27, 2023 May 31, 2026
NCT06047080 Recruiting Phase 3 An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma September 18, 2023 February 28, 2029
NCT06250959 Recruiting Phase 2 RDC-Blinatumomab Versus hyperCVAD for Ph-negative B-ALL. February 5, 2024 December 31, 2026
NCT03899337 Recruiting Phase 2 A Trial of CHOP-R Therapy, With or Without Acalabrutinib, in Patients With Newly Diagnosed Richter's Syndrome July 23, 2019 May 31, 2027
NCT05981014 Recruiting Phase 1/Phase 2 Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes as Neoadjuvant Therapy for HER2-Negative Breast Cancer August 1, 2023 May 31, 2035
NCT03943901 Recruiting Phase 2 Split-Dose R-CHOP for Older Adults With DLBCL February 17, 2021 May 2026
NCT05453500 Recruiting Phase 2 Chemotherapy (DA-EPOCH+/-R) and Targeted Therapy (Tafasitamab) for the Treatment of Newly-Diagnosed Philadelphia Chromosome Negative B Acute Lymphoblastic Leukemia March 27, 2023 September 1, 2030
NCT05422066 Recruiting Phase 2 Selinexor Plus R-CHOP in High-risk GCB-subtype Diffuse Large B-Cell Lymphoma July 26, 2022 December 31, 2025
NCT05406401 Recruiting Phase 2 A Study of Zilovertamab Vedotin (MK-2140) in Combination With Cyclophosphamide, Doxorubicin, and Prednisone Plus Rituximab or Rituximab Biosimilar (Truxima) (R-CHP) in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-007) July 14, 2022 January 26, 2026
NCT04231877 Suspended Phase 1 Polatuzumab Vedotin and Combination Chemotherapy for the Treatment of Untreated Aggressive Large B-cell Lymphoma October 27, 2020 December 1, 2031
NCT03145558 Suspended Phase 2 TATE Versus TACE in Intermediate Stage HCC December 5, 2017 December 31, 2024
NCT03150693 Suspended Phase 3 Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia June 1, 2017 August 2025
NCT02758366 Terminated Phase 2 Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse Intrinsic Pontine Glioma February 2016 January 16, 2020
NCT02419469 Terminated Phase 2 Augmented Berlin-Frankfurt-Munster Therapy Plus Ofatumumab for Young Adults With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma November 13, 2015 June 22, 2017
NCT02379585 Terminated Phase 1/Phase 2 Fasting on Newly Diagnosed Breast Cancer January 2013 August 2015
NCT02855359 Terminated Phase 2 Denintuzumab Mafodotin (SGN-CD19A) Combined With RCHOP or RCHP Versus RCHOP Alone in Diffuse Large B-Cell Lymphoma or Follicular Lymphoma August 2016 May 15, 2018
NCT02359162 Terminated Phase 3 Efficacy and Safety Study of P-Gemox vs.EPOCH as First-line Chemotherapy to Treat NK/T-cell Lymphoma With Early Stage May 2015 June 2017
NCT02261805 Terminated Phase 1/Phase 2 A Phase I/II Study of Ganetespib in Combination With Doxorubicin October 2014 October 2016
NCT02255110 Terminated Phase 2 A Japanese Trial of TH-302 in Subjects With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma December 10, 2014 January 12, 2016
NCT02958163 Terminated Phase 2 Clinical Trial Comparing TACE With TACE + SABR in Stage BCLC B HCC (HepSTAR) February 20, 2017 October 17, 2017
NCT01964755 Terminated Phase 2 Chemotherapy for Relapsed Epstein Barr Virus Associated Lymphoma April 21, 2009 June 7, 2018
NCT01925612 Terminated Phase 2 Study of Brentuximab Vedotin Combined With RCHOP or RCHP in Front-line Treatment of Patients With Diffuse Large B-cell Lymphoma (DLBCL) August 2013 May 1, 2017
NCT01887587 Terminated Phase 1 Vincristine, Doxorubicin, And Dexamethasone + Ixazomib in Acute Lymphoblastic Leukemia (ALL), Lymphoblastic Lymphoma Or Mixed Phenotype Acute Leukemia June 2013 February 29, 2016
NCT01779050 Terminated Phase 2 Effect of Trastuzumab on Disease Free Survival in Early Stage HER2-Negative Breast Cancer Patients With ERBB2 Expressing Disseminated Tumor Cells December 19, 2013 September 1, 2021
NCT01746173 Terminated Phase 2 CHOEP + High Dose Therapy + Auto SCT for T-Cell Lymphoma July 2013 October 2014
NCT01659554 Terminated Phase 2 A Phase II Combined Modality Protocol of Debulking Surgery With HIPEC Followed by Intraperitoneal Chemotherapy for the Treatment of Recurrent Ovarian, Primary Peritoneal & Fallopian Tube Cancers March 2012 April 2014
NCT03225924 Terminated Phase 1/Phase 2 Study of Entospletinib (ENTO) in Newly Diagnosed DLBCL Patients With aaIPI>=1 Treated by Chemiotherapy July 26, 2017 October 18, 2019
NCT01659099 Terminated Phase 3 GA In NEwly Diagnosed Diffuse Large B Cell Lymphoma September 2012 December 31, 2017
NCT01548573 Terminated Phase 2 Tandem Auto Transplantation in Myeloma Patients With <12 Months of Prior Treatment May 2012 August 2014
NCT01498588 Terminated Phase 2 Trial of Eribulin Followed by Doxorubicin & Cyclophosphamide for Her2-negative, Locally Advanced Breast Cancer November 2011 June 2015
NCT03329378 Terminated Phase 2 Neoadjuvant Dose-Dense For Early Her2Neu Positive Breast Cancer January 24, 2019 March 7, 2021
NCT01390584 Terminated Phase 2 Chemotherapy Based on PET Scan in Treating Patients With Stage I or Stage II Hodgkin Lymphoma May 24, 2013 May 18, 2018
NCT01321008 Terminated Phase 1/Phase 2 Stage I/II Nasal NK Cell Lymphoma May 2011 May 2013
NCT01313884 Terminated Phase 2 Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings Sarcoma May 2011 July 2014
NCT01287741 Terminated Phase 3 A Study of Obinutuzumab in Combination With CHOP Chemotherapy Versus Rituximab With CHOP in Participants With CD20-Positive Diffuse Large B-Cell Lymphoma (GOYA) July 26, 2011 January 31, 2018
NCT03515200 Terminated Phase 1 Treatment With Combination Chemotherapy for Relapsed or Refractory Acute Lymphoblastic Leukemia April 20, 2018 July 29, 2020
NCT01258634 Terminated Phase 1 A Study of Pre-Operative Treatment of Newly-Diagnosed, Surgically-Resectable Osteosarcoma With Doxorubicin, Ifosfamide, Etoposide, and Cisplatin With Early Metabolic Assessment of Response July 2010 November 2011
NCT01220128 Terminated Phase 2 Evaluation of an Anti-cancer Immunotherapy Combined With Standard Neoadjuvant Treatment in Patients With WT1-positive Primary Invasive Breast Cancer April 11, 2011 November 14, 2014
NCT01186328 Terminated Phase 1 EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL) August 24, 2010 January 10, 2012
NCT01177683 Terminated Phase 1/Phase 2 Bendamustine in Combination With Bortezomib and Pegylated Liposomal Doxorubicin for Multiple Myeloma July 2010 December 2017
NCT01104298 Terminated Phase 2 Doxorubicin vs. Trabectedin Plus Doxorubicin in Non Operable and/or Metastatic STS November 2009 May 2014
NCT01090128 Terminated Phase 1 Study of Neoadjuvant Chemotherapy With Nanoparticle Albumin Bound Paclitaxel, Doxorubicin and Cyclophosphamide (NAC) in Patients With Stages II-III Breast Cancer September 2008 March 24, 2017
NCT03698227 Terminated Phase 2 OlaReDo - Olaratumab and Rechallenge With Doxorubicin in Soft Tissue Sarcoma Patients November 12, 2018 June 25, 2020
NCT01014767 Terminated Phase 3 Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid Plexus Tumors November 2009 January 2014
NCT00960063 Terminated Phase 1 A Study of Robatumumab (SCH 717454, MK-7454) in Combination With Different Treatment Regimens in Pediatric Participants With Advanced Solid Tumors (P05883, MK-7454-006) November 11, 2009 December 22, 2010
NCT00928200 Terminated Phase 1 Erwinase for Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) (IND 104224) April 13, 2009 June 4, 2010
NCT00883116 Terminated Phase 3 A Study of Ixabepilone as Second-line Therapy for Locally Advanced, Recurrent, or Metastatic Endometrial Cancer August 2009 February 2014
NCT00859495 Terminated Phase 2 Trimodal Lung-Sparing Treatment of Pleural Mesothelioma February 2008 February 2012
NCT00841945 Terminated Phase 3 Treatment of Aggressive Localized Lymphoma April 2005 February 2017
NCT03860844 Terminated Phase 2 Isatuximab in Combination With Chemotherapy in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia August 6, 2019 May 26, 2023
NCT03864419 Terminated Phase 1 Rituximab Hyaluronidase in Combination With Chemotherapy in Treating Aggressive B-cell Lymphoma in Uganda October 24, 2019 July 26, 2023
NCT03878524 Terminated Phase 1 Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial April 1, 2020 December 10, 2020
NCT03912818 Terminated Phase 2 Durvalumab and Standard Chemotherapy Before Surgery in Treating Patients With Variant Histology Bladder Cancer April 10, 2019 August 11, 2022
NCT00809341 Terminated Phase 2 R-ICE and High-Dose Cyclophosphamide With PET/CT for Diffuse Large B-Cell Non-Hodgkin's Lymphoma January 2009 April 2014
NCT00808899 Terminated Phase 2 Neuroblastoma Protocol 2008: Therapy for Children With Advanced Stage High Risk Neuroblastoma December 2008 July 2009
NCT00755261 Terminated Phase 2 Phase II Study of Doxorubicin and Avastin® in Sarcoma. September 2008 November 2010
NCT00673179 Terminated N/A Doxorubicin With Cisplatin, High-Dose Methotrexate, and Additional Risk-Adapted Outpatient Chemotherapy May 2008 November 2010
NCT00635726 Terminated Phase 2 Methotrexate, Vinblastine, Doxorubicin and Cisplatin (MVAC) Followed by Gemcitabine Plus Cisplatin (GEM+CDDP) in Locally Advanced or Metastatic Bladder Cancer February 2008 February 2013
NCT00609765 Terminated Phase 2 Avastin, Fluorouracil, Doxorubicin and Streptozocin in Locally Advanced and Metastatic Pancreatic Endocrine Tumors August 2007 March 2008
NCT00512980 Terminated Phase 2 PVAG-14 Pilot for Intermediate Stages Hodgkin Lymphoma August 2008
NCT00484601 Terminated Phase 2 Ifosfamide and Doxorubicin in Patients With Refractory Nasopharyngeal Carcinoma April 15, 2004 November 7, 2007
NCT00461344 Terminated Phase 2 Docetaxel + Doxorubicin as Neoadjuvant Chemotherapy in Patients With Breast Cancer July 2004 August 2007
NCT00450385 Terminated Phase 2 Genes in Predicting Outcome of Patients With DLBCL Treated With Rituximab and Combination Chemotherapy (R-CHOP) April 24, 2007 May 2016
NCT00439296 Terminated Phase 1/Phase 2 ABT-751 With Chemotherapy for Relapsed Pediatric ALL May 22, 2006 September 23, 2009
NCT04780464 Terminated Phase 3 A 3 Arm Randomized Study on Health-related QoL of Elderly Patients With Advanced Soft Tissue Sarcoma April 11, 2022 November 11, 2023
NCT00361621 Terminated Phase 2 Ph II CHOP+Velcade in Mediastinal LBCL July 2006 May 2008
NCT00235235 Terminated A Correlative Study for Predicting Response and Toxicity in Patients Receiving Chemotherapy for Breast Cancer September 2005 December 2010
NCT00225173 Terminated Phase 2 Combination Chemotherapy +/- Radiation in High Risk Hodgkin's Disease October 2001 September 2006
NCT04996004 Terminated Phase 2 A Study to Learn About the Study Medicine (Called Ontorpacept or TTI-621) Given Alone and in Combination With Doxorubicin in People With Leiomyosarcoma June 22, 2021 December 7, 2023
NCT05100628 Terminated Phase 1 A Study of NOX66 Plus Doxorubicin in Anthracycline-naïve, Adult Patients With Soft Tissue Sarcoma February 11, 2022 May 26, 2023
NCT00176293 Terminated Phase 2 Randomized Phase II Trial of Doxil With or Without Dexamethasone for Metastatic Hormone Refractory Prostate Cancer October 2005 February 2007
NCT00165087 Terminated Phase 3 Treatment of Childhood Acute Lymphoblastic Leukemia January 1996 September 2006
NCT00135499 Terminated Phase 3 R-ACVBP Versus R-CHOP in Patients Aged 60-65 With Diffuse Large B-cell Lymphoma October 16, 2001 April 27, 2010
NCT05207514 Terminated Phase 3 Compare the Efficacy and the Safety of Taxotere and Nanoxel M as Neoadjuvant Chemotherapy in Breast Cancer March 31, 2022 May 9, 2024
NCT00126191 Terminated Phase 2 Intensive Chemotherapy and Rituximab in the Treatment of Burkitt Lymphoma July 2005 June 2011
NCT00088881 Terminated Phase 2 Rituximab, Combination Chemotherapy, and 90-Yttrium Ibritumomab Tiuxetan for Patients With Stage I or II Non-Hodgkin's Lymphoma December 2004 March 2011
NCT00074490 Terminated Phase 2 Donor Stem Cell Transplant With No or Low-Intensity Chemotherapy Using Sirolimus and Treated Immune Cells to Treat Blood and Lymph Cancers January 1, 2004 August 16, 2017
NCT00038142 Terminated Phase 2 Vincristine, Doxorubicin, Cyclophosphamide and Dexrazoxane (VACdxr) in High Risk Ewing's Sarcoma Patients November 1997 March 2016
NCT00060346 Terminated Phase 2 Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Waldenstrom's Macroglobulinemia October 5, 2004 August 2012
NCT02560051 Terminated Phase 2 Hormone Therapy Plus Chemotherapy as Initial Treatment for Local Failures or Advanced Prostate Cancer November 2015 September 14, 2017
NCT02531308 Terminated Phase 2 Metformin in Combination With Standard Induction Therapy for Large B-cell Lymphoma (DLBCL) July 2015 July 2016
NCT02494713 Terminated Phase 2 Hormonal Therapy and Chemotherapy Followed by Prostatectomy in Patients With Prostate Cancer October 2015 September 14, 2017
NCT02472353 Terminated Phase 2 Use of Metformin to Reduce Cardiac Toxicity in Breast Cancer July 2014 May 23, 2018
NCT02626455 Terminated Phase 3 Study of Copanlisib in Combination With Standard Immunochemotherapy in Relapsed Indolent Non-Hodgkin's Lymphoma (iNHL) January 6, 2016 November 10, 2023
NCT02420717 Terminated Phase 2 Ruxolitinib Phosphate or Dasatinib With Chemotherapy in Treating Patients With Relapsed or Refractory Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia July 15, 2015 January 20, 2021
NCT02732015 Terminated Phase 2 Rolapitant Hydrochloride in Preventing Nausea/Vomiting in Patients With Sarcoma Receiving Chemotherapy October 12, 2016 July 10, 2020
NCT02419755 Terminated Phase 2 Bortezomib and Vorinostat in Younger Patients With Refractory or Relapsed MLL Rearranged Hematologic Malignancies April 14, 2015 December 31, 2016
NCT03553537 Unknown status Phase 3 Efficacy and Safety of Decitabine Plus CHOP vs CHOP in Patients With Untreated Peripheral T-Cell Lymphoma June 2018 July 2021
NCT04498793 Unknown status Phase 2 Study of Tislelizumab Plus Chemotherapy vs Chemotherapy as Perioperative Treatment in Participants With HER2 Negative Breast Cancer September 2020 December 2022
NCT04181489 Unknown status Phase 2 Sintilimab in Combination With R-CHOP in Patients With Treatment-naive EBV-positive DLBCL, NOS January 1, 2019 December 30, 2023
NCT00718484 Unknown status Phase 2 A Study of Palifosfamide Tris Plus Doxorubicin Versus Doxorubicin in Unresectable or Metastatic Soft-tissue Sarcoma August 2008 April 2014
NCT01920503 Unknown status International Registry on Cholangiocarcinoma Treatment July 2013 August 2020
NCT03018626 Unknown status Phase 3 R-ACVBP and DA-EPOCH-R in Patients With Non-GCB DLBCL July 27, 2017 January 2021
NCT02078388 Unknown status Correlation Between Genetic Variants and Long-term Cardiac Effects Induced by Doxorubicin in Breast Cancer Patients November 2013
NCT02953184 Unknown status Phase 2 Marched Pair Study Conventional Doxorubicin(DOX) Versus Pegylated Liposomal Doxorubicin(PLD) Neoadjuvant Chemotherapy November 2016 November 2020
NCT02951728 Unknown status Phase 1/Phase 2 Decitabine Plus R-CHOP in Diffuse Large B-cell Lymphoma October 2016 October 2020
NCT02812654 Unknown status Phase 2 Ifosfamide, Doxorubicin and Hypofractionated Radiotherapy in Neoadjuvant Sarcoma Treatment March 2015 March 2019
NCT02918747 Unknown status Phase 2 PEG-ASP+Gemoxd vs. PEG-ASP+CHOP as First-line Chemotherapy to Treatment NK/T-cell Lymphoma With Early Stage September 2016 December 2021
NCT02894645 Unknown status Phase 4 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study October 2008
NCT02362165 Unknown status Phase 3 CyBorD vs. PAD in the Treatment of Newly Diagnosed Multiple Myeloma April 2015 May 2018
NCT02866370 Unknown status Phase 2 Study Of Nintedanib Compared To Chemotherapy in Patients With Recurrent Clear Cell Carcinoma Of The Ovary Or Endometrium April 2015 March 2021
NCT02559154 Unknown status Phase 4 Modified Bortezomib-based Combination Therapy for Multiple Myeloma July 2010 December 2018
NCT00209222 Unknown status Phase 3 Efficacy of R-CHOP vs R-CHOP/R-DHAP in Untreated MCL July 2004 December 2014
NCT00209209 Unknown status Phase 3 Induction Chemotherapy (R-CHOP Vs. R-FC) Followed by Interferon Maintenance Versus Rituximab Maintenance in MCL January 14, 2004 December 2018
NCT05049473 Unknown status Phase 2 Treatment of Mature B-ALL and Burkitt Lymphoma (BL) in Adult Patients. BURKIMAB-14. January 2014 January 2024
NCT00324467 Unknown status Phase 2 Tailoring Treatment for B Cell Non-hodgkin's Lymphoma Based on PET Scan Results Mid Treatment August 2006 December 2021
NCT02784015 Unknown status Phase 2 Response Based Treatment for Children With Unresectable Localized Soft Tissue Sarcoma May 2016 May 2023
NCT02685657 Unknown status Phase 2 Neoadjuvant Chemotherapy Docetaxel With or Without SELUMETINIB in Patients With Triple Negative Breast Cancer September 2016
NCT02506777 Unknown status Phase 2 Neoadjuvant FDC With Melatonin or Metformin for Locally Advanced Breast Cancer. July 2015 August 2020
NCT02428751 Unknown status Phase 3 R-CHOP Versus R-CDOP as First-line Treatment for Elderly Patients With Diffuse Large-B-cell Lymphoma September 2015 May 2020
NCT02771743 Unknown status Phase 2 Response-based Treatment of High-risk Neuroblastoma April 2015 March 2023
NCT00131027 Unknown status Phase 3 High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL) September 2002 September 2011
NCT04656262 Unknown status Phase 3 Low Dose Continuous Cyclophosphamide vs Standard Doxorubicin in Advanced Sarcoma Elderly Patients September 10, 2018 January 31, 2023
NCT02753647 Unknown status Phase 2 Chidamide Plus R-CHOP in Elderly DLBCL April 2016 April 2019
NCT04025593 Unknown status Phase 2 Biomarker Guided Treatment in DLBCL July 17, 2019 June 1, 2023
NCT03975205 Unknown status Early Phase 1 To Study the Concentration Level of, Doxil, and Doxorubicin at Various Time Frames July 1, 2019 December 31, 2019
NCT03952572 Unknown status Phase 3 Efficacy and Safety of CDOP vs CHOP for Newly Diagnosed Peripheral T-cell Lymphoma May 10, 2019 April 30, 2023
NCT02631109 Unknown status Phase 3 L-DEP Regimen as a Salvage Therapy for Refractory Epstein Barr Virus-induced Hemophagocytic Lymphohistiocytosis December 2015 November 2019
NCT03949634 Unknown status Phase 3 Cardiac Safety and Efficacy for Early-stage Breast Cancer Patients Treated With Pegylated Liposomal Doxorubicin(PLD) September 1, 2017 October 31, 2020
NCT03853044 Unknown status Phase 2 Study Evaluating the Safety and Efficacy of C-CHOP in Untreated Subjects With Angioimmunoblastic T Cell Lymphoma December 29, 2018 December 2022
NCT00820690 Unknown status Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer July 2008 September 2017
NCT03734068 Unknown status Chemoembolization Using LifePearl Polyethylene Glycol Drug Eluting Microspheres With Doxorubicin in HCC June 13, 2018 December 2021
NCT00990860 Unknown status Phase 2 Study in Asia of the Combination of TACE With Sorafenib in HCC Patients February 2009
NCT01009970 Unknown status Phase 2 Study With Rituximab, Cyclophosphamide, Doxorubicin Liposomal (Myocet®), Vincristine, Prednisone, (R-COMP) to Treat Non-Hodgkin's Lymphoma May 2010 May 2012
NCT03617432 Unknown status Phase 2 Chidamide Combined With CHOPE Regimen for Peripheral T-cell Lymphoma Patients August 28, 2018 September 30, 2022
NCT00486668 Unknown status Phase 3 A Study of AC Followed by a Combination of Paclitaxel Plus Trastuzumab or Lapatinib or Both Given Before Surgery to Patients With Operable HER2 Positive Invasive Breast Cancer July 2007 March 2017
NCT03542669 Unknown status Phase 1 Study of 6b11-OCIK Injection Treatment in Patients With Recurrent Drug-resistant Ovarian Cancer August 3, 2018 December 30, 2023
NCT01272557 Unknown status Phase 2 Sorafenib Plus Doxorubicin Versus Sorafenib Alone for the Treatment of Advanced Hepatocellular Carcinoma: a Randomized Phase II Trial December 2010 December 2014
NCT03497702 Unknown status Phase 2 Neo-adjuvant Chemotherapy With Letrozole in Patients With Estrogen Receptor Positive/HER-2 Negative Breast Cancer May 8, 2017 January 2024
NCT03340376 Unknown status Phase 2 Doxorubicin Alone Versus Atezolizumab Alone Versus Doxorubicin and Atezolizumab in Recurrent Cervical Cancer August 30, 2017 September 2022
NCT01468740 Unknown status Phase 2 Prospective Study on HIV-related Hodgkin Lymphoma March 2004 July 2012
NCT01547741 Unknown status Phase 3 Docetaxel and Cyclophosphamide Compared to Anthracycline-Based Chemotherapy in Treating Women With HER2-Negative Breast Cancer April 2012 November 2023
NCT01670500 Unknown status Phase 2 Cisplatin vs. Doxorubicin/Cyclophosphamide in BrCa October 2012 April 2023
NCT01719835 Unknown status Phase 2 CHOP vs GEM-P in 1st Line Treatment of T-cell Lymphoma, Multicentre Phase II Study March 2012 August 2022
NCT02858804 Unknown status Phase 4 EDOCH Alternating With DHAP for New Diagnosed Younger MCL January 2016 June 2020
NCT03108300 Unknown status Phase 2 Use of Propranolol Hydrochloride in the Treatment of Metastatic STS August 30, 2019 August 30, 2021
NCT01858207 Unknown status Phase 2 Combine TACE and RFA Versus RFA Monotherapy in Unilobar HCC of 3.1 to 7 cm Patient January 2012 December 2014
NCT04038489 Withdrawn Phase 2 COX Inhibition and Biomarkers During Neoadjuvant Chemoendocrine Therapy for ER+, HER2- Stage I-III Breast Cancer October 18, 2019 April 30, 2023
NCT00017160 Withdrawn Phase 2 Combination Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Primary or Recurrent Sarcoma
NCT03285607 Withdrawn Phase 1 MCS110 Combined With Neoadjuvant Doxorubicin, Cyclophosphamide, and Weekly Paclitaxel in Patients With Hormone-Receptor Positive and HER2- Breast Cancer September 30, 2018 February 28, 2021
NCT02215876 Withdrawn Phase 2 Neoadjuvant Doxorubicin/Cyclophosphamide Followed by Eribulin Chemotherapy (ACE) in Operable HER2-negative Breast Cancer September 2014 March 2020
NCT05934097 Withdrawn Phase 1 FT596 in Combination With R-CHOP in Subjects With B-Cell Lymphoma December 2022 May 2039
NCT02228512 Withdrawn Phase 1/Phase 2 Study of Pomalidomide Combined With Modified DA-EPOCH and Rituximab in KSHV-Associated Lymphomas August 15, 2014 May 5, 2015
NCT04852367 Withdrawn Phase 1 PanDox: Targeted Doxorubicin in Pancreatic Tumours June 16, 2021 March 30, 2023
NCT05177796 Withdrawn Phase 2 Panitumumab and Pembrolizumab in Combination With Neoadjuvant Chemotherapy for the Treatment of Stage III-IV Triple Negative Breast Cancer March 11, 2022 July 26, 2023
NCT02637375 Withdrawn N/A A Pilot Preoperative Trial of Ganetespib With Paclitaxel for Triple-Negative Breast Cancer May 2016 December 2018
NCT03111069 Withdrawn Phase 1 Study of Doxorubicin and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Intraoperative Brachytherapy for Unresectable or Refractory Pelvic and Abdominal Rhabdomyosarcoma and Undifferentiated Sarcomas in Children August 2018 August 2021
NCT04762901 Withdrawn Phase 1 LCI-BRE-MTN-NIR-001:Ph I Study of Niraparib in Combo With Standard Chemo in Metastatic Trip Neg Breast Cancer April 1, 2021 January 2026
NCT03059615 Withdrawn Phase 2 A Phase 2a, Open-Label, Two Stage Study of Nerofe or Nerofe With Doxorubicin in Subjects With AML or MDS October 25, 2018 July 26, 2020
NCT01857726 Withdrawn N/A Comparison of TACE Versus TACE/TACI Combination in Advanced Hepatocellular Carcinoma With Portal Vein Invasion July 2013 December 2016
NCT01159236 Withdrawn N/A Molecular Triaging of Newly Diagnosed Breast Cancer September 2010
NCT06210750 Withdrawn Phase 2 Adding Targeted Drugs to Usual Chemotherapy for Adults With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LBL) August 9, 2024 September 22, 2026
NCT00124956 Withdrawn Phase 1/Phase 2 Doxorubicin Pharmacokinetic (PK) Study June 2003
NCT04974996 Withdrawn Phase 1 A Study to Evaluate the Tolerability, Safety, Pharmacokinetics, and Antitumor Activity of Loncastuximab Tesirine in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated Diffuse Large B-cell Lymphoma (LOTIS-8) February 1, 2022 May 5, 2027
NCT03005015 Withdrawn Phase 2 Lenvatinib in Second Line Endometrial Carcinoma January 2017
NCT03437070 Withdrawn Phase 1 Trabectedin, Doxorubicin and Olaratumab in Patients With Metastatic or Recurrent Leiomyosarcoma June 2019 June 2023
NCT01327521 Withdrawn Phase 3 Transarterial Chemoembolization vs CyberKnife for Recurrent Hepatocellular Carcinoma February 2011
NCT02053597 Withdrawn Phase 2 TRIal evalUating the Menstrual and Ovarian Function of Young Breast Cancer Patients Treated With a cycloPHosphamide-free Regimen October 2014 July 2015
NCT01415765 Withdrawn Phase 1/Phase 2 MLN4924 Compared With MLN4924 Plus Chemotherapy for Large B-cell Lymphoma July 15, 2011 January 7, 2014
NCT04639843 Withdrawn Phase 1 Doxorubicin, CC-(486) (5-azacitidine), Romidepsin, and Duvelisib (hARD) for T-cell Lymphoma November 3, 2022 November 3, 2022