Annotation Detail
Information
- Associated Genes
- ATF2
- Associated Variants
- ATF2 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- The ATF2 peptide spanning amino acids 50-100 - which acts as an AFT2 inhibitor - elicited the most efficient increase in the sensitivity of human melanoma cells to UV radiation or treatment by Adriamycin, verapamil or UCN-01, as revealed by apoptosis assays
- MMMP State
- downregulated by
- MMMP Molecule
- ATF2
- MMMP Modifier
- ATF2 peptide (antagonist)
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Doxorubicin
- MMMP Drug Alias
- Adriamycin (R)
- MMMP Model
- 3
- MMMP Reference
- Bhoumik A, Clin Cancer Res 2001, 7:331-42
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Doxorubicin | Sensitivity | true |