Annotation Detail
Information
- Associated Genes
- APAF1
- Associated Variants
- APAF1 EXPRESSION
- Source Database
- MMMP
- Description
- APAF1-negative melanomas are chemoresistant and are unable to execute a typical apoptotic programme in response to p53 activation: restoring physiological levels of Apaf-1 through gene transfer or 5aza2dC treatment markedly enhances chemosensitivity
- MMMP State
- expressed
- MMMP Molecule
- APAF1
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Doxorubicin
- MMMP Drug Alias
- Adriamycin (R)
- MMMP Model
- 3
- MMMP Reference
- Soengas MS, Nature 2001, 409:207-11
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Doxorubicin | Sensitivity | true |