Annotation Detail

Information

Associated Genes: TP53
Associated Variants: TP53 DELETERIOUS MUTATION
TP53 DELETERIOUS MUTATION
Associated Disease: stomach carcinoma
Source Database: CIViC Evidence
Description: In a study of 25 patients with advanced gastric cancer, mutations in TP53 were identified in 32% of primary tumors. TP53 mutations were associated with an improved response to preoperative treatment of a modified EAP protocol (combination of doxorubicin, etoposide and cisplatin). Patients with mutations in TP53 had an increased median survival compared to patients with wildtype TP53 (18.5mo vs. 10.2mo, P=0.044).
Variant Origin: somatic
Variant Origin: Somatic
Evidence URL: https://civic.genome.wustl.edu/links/evidence_items/2820
Gene URL: https://civic.genome.wustl.edu/links/genes/45
Variant URL: https://civic.genome.wustl.edu/links/variants/222
Rating: 1
Evidence Type: Predictive
Disease: Stomach Carcinoma
Evidence Direction: Supports
Drug: Cisplatin,Doxorubicin,Etoposide
Evidence Level: C
Clinical Significance: Sensitivity/Response
Pubmed: 14514923

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