Annotation Detail
Information
- Associated Genes
- IKBKB
- Associated Variants
- IKBKB UNDEREXPRESSION
- Source Database
- MMMP
- Description
- KINK-1 ultimately acts by inhibiting NFkB (which is upregulated by some chemotherapeutic drugs). KINK-1 worked also in mice with syngeneic melanoma. The synergism was demonstrated also in an in vivo mouse model
- MMMP State
- inhibited by
- MMMP Molecule
- IKKB
- MMMP Molecule Alias
- IKB kinase beta
- MMMP Modifier
- KINK-1
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Doxorubicin
- MMMP Drug Alias
- Adriamycin (R)
- MMMP Model
- 3
- MMMP Reference
- Schon M, J Natl Cancer Inst 2008, 100:862-75
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Doxorubicin | Sensitivity | true |