Annotation Detail
Information
- Associated Genes
- TOP2A
- Associated Variants
-
TOP2A EXPRESSION
TOP2A EXPRESSION - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- In a retrospective study, TOP2A expression was assessed by IHC for 108 breast cancer patients (from TAX 303 trial). TOP2A expression was associated with a higher probability of response in doxorubicin treated but not in docetaxel treated breast cancer patients.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/909
- Gene URL
- https://civic.genome.wustl.edu/links/genes/5848
- Variant URL
- https://civic.genome.wustl.edu/links/variants/383
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Doxorubicin
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 15486187
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Doxorubicin | Sensitivity | true |