Annotation Detail
Information
- Associated Genes
- APP
- Associated Variants
- APP UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Blocking the expression of APP by RNA interference impairs the proliferation of metastatic melanoma cells and leads to their terminal and irreversible differentiation. In addition, suppressing APP expression in a metastatic melanoma cell line renders the cells susceptible to several chemotherapeutic agents
- MMMP State
- downregulated by
- MMMP Molecule
- APP
- MMMP Molecule Alias
- Beta-amyloid precursor protein
- MMMP Modifier
- APP siRNA
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Doxorubicin
- MMMP Drug Alias
- Adriamycin (R)
- MMMP Model
- 3
- MMMP Reference
- Botelho MG, J Invest Dermatol 2010, 130:1400-10
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Doxorubicin | Sensitivity | true |