Annotation Detail
Information
- Associated Genes
- ZEB1
- Associated Variants
-
ZEB1 EXPRESSION
ZEB1 EXPRESSION - Associated Disease
- mantle cell lymphoma
- Source Database
- CIViC Evidence
- Description
- Downregulation of ZEB1 expression in mantle cell lymphoma cell lines and mouse xenografts led to enhanced sensitivity towards treatment with doxorubicin, cytarabin and gemcitabine.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/899
- Gene URL
- https://civic.genome.wustl.edu/links/genes/5649
- Variant URL
- https://civic.genome.wustl.edu/links/variants/376
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Mantle Cell Lymphoma
- Evidence Direction
- Supports
- Drug
- Doxorubicin,Cytarabine,Gemcitabine
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 24013721
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Cytarabine | Resitance or Non-Reponse | true |
| Doxorubicin | Resitance or Non-Reponse | true |
| Gemcitabine | Resitance or Non-Reponse | true |