Annotation Detail
Information
- Associated Genes
- LRP1B
- Associated Variants
-
LRP1B EXON 12-22 DELETION
(
ENST00000389484.8 )
LRP1B EXON 12-22 DELETION ( ENST00000389484.8 ) - Associated Disease
- ovarian cancer
- Source Database
- CIViC Evidence
- Description
- A minimum common region of deletion of 0.19Mb, encompassing exons 12–22 of LRP1B4 was observed in 4 patients exhibiting acquired treatment resistance. Transfection of mLRP1B4, a fully functional minigene of LRP1B, in IGROV1 and OVCAR4 ovarian cell lines with low expression of LRP1B4 increased sensitivity to liposomal doxorubicin but not doxorubicin. siRNA knockdown of LRP1B4 in JHOS3 and Kuramochi ovarian cancer cell lines decreased sensitivity to liposomal doxorubicin but not doxorubicin.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/679
- Gene URL
- https://civic.genome.wustl.edu/links/genes/12146
- Variant URL
- https://civic.genome.wustl.edu/links/variants/266
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Ovarian Cancer
- Evidence Direction
- Supports
- Drug
- Doxorubicin
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 22896685
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Doxorubicin | Resitance or Non-Reponse | true |