Annotation Detail
Information
- Associated Genes
- SMARCB1
- Associated Variants
- SMARCB1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- The tumor suppressor SNF5, the core subunit of SWI/SNF complex, has been shown to regulate cell differentiation, cell cycle control, and apoptosis. Knockdown of SNF5 in melanoma cell lines resulted in significant chemoresistance
- MMMP State
- downregulated by
- MMMP Molecule
- SNF5
- MMMP Modifier
- SNF5 siRNA
- MMMP Relationship
- resistance to
- MMMP Drug
- Doxorubicin
- MMMP Drug Alias
- Adriamycin (R)
- MMMP Model
- 3
- MMMP Reference
- Lin H, Clin Cancer Res 2009, 15:6404-11
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Doxorubicin | Resitance or Non-Reponse | true |