chr16:69740899:> Detail (hg19)

Information

Genome

Assembly Position
hg19 chr16:69,740,899-69,760,571
hg38 chr16:69,706,996-69,726,668 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
<0.001 renal cell carcinoma NA BeFree Detail
0.019 squamous cell carcinoma The additive effect of smoking and the NQO1 C-T/C-T diplotype was more apparent ... BeFree,GAD,LHGDN 25729241 Detail
0.019 squamous cell carcinoma The NQO1 protein showed a mainly cytoplasmic staining pattern in lung cancer cel... BeFree,GAD,LHGDN 25880877 Detail
<0.001 Cardiovascular Diseases NA BeFree Detail
0.002 Neoplastic Cell Transformation NA GAD Detail
0.002 intracranial aneurysm NA GAD Detail
0.001 Malignant tumor of cervix NA BeFree Detail
0.005 Uterine Cervical Neoplasm NA GAD Detail
0.120 cholestasis NA CTD_human Detail
0.005 Chromosome Aberrations NA GAD Detail
<0.001 Congenital chromosomal disease This study was conducted to determine the association between arsenic exposure a... BeFree 25395496 Detail
<0.001 colitis NA BeFree Detail
0.003 ulcerative colitis NA BeFree,GAD Detail
0.080 Colonic Neoplasms NA BeFree,RGD Detail
0.004 colorectal carcinoma NA BeFree Detail
0.132 Colorectal Neoplasms NA BeFree,CTD_human,GAD Detail
<0.001 Coronary Arteriosclerosis NA BeFree Detail
0.003 Coronary heart disease NA BeFree,GAD Detail
0.120 contact dermatitis NA CTD_human Detail
<0.001 Diabetes NA BeFree Detail
<0.001 diabetes mellitus NA BeFree Detail
0.120 Diabetes Mellitus, Experimental NA CTD_human Detail
0.003 Diabetes Mellitus, Insulin-Dependent NA BeFree,GAD Detail
0.008 Diabetes Mellitus, Non-Insulin-Dependent NA BeFree,GAD Detail
0.005 DNA Damage NA GAD Detail
<0.001 Drug abuse NA BeFree Detail
0.005 Dyskinetic syndrome NA GAD,LHGDN Detail
<0.001 endometriosis NA BeFree Detail
0.009 Esophageal Neoplasms NA BeFree,GAD Detail
<0.001 esophagitis NA BeFree Detail
<0.001 Exanthema NA BeFree Detail
0.080 Fatty Liver NA RGD Detail
0.002 Fetal Growth Retardation NA GAD Detail
<0.001 gastroesophageal reflux disease NA BeFree Detail
<0.001 glioblastoma NA BeFree Detail
0.017 Head and Neck Neoplasms NA GAD Detail
<0.001 Heart Diseases NA BeFree Detail
0.002 Heart failure NA GAD Detail
<0.001 congestive heart failure NA BeFree Detail
0.120 hemolytic-uremic syndrome NA CTD_human Detail
<0.001 Herpes Simplex Infections NA BeFree Detail
0.002 Hodgkin Disease NA GAD Detail
0.120 hyperglycemia NA CTD_human Detail
<0.001 Hypertensive disease The aim of this study was to examine the individual and interactive associations... BeFree 25529925 Detail
0.002 male infertility NA GAD Detail
<0.001 ischemia NA BeFree Detail
0.120 Kidney Diseases NA CTD_human Detail
0.005 Laryngeal neoplasm NA GAD Detail
0.024 leukemia NA BeFree,GAD,LHGDN Detail
0.007 chronic lymphocytic leukemia NA BeFree,GAD Detail
0.004 Acute lymphocytic leukemia NA BeFree Detail
0.011 Leukemia, Lymphocytic, Acute, L1 NA BeFree,GAD Detail
0.022 Leukemia, Myelocytic, Acute NA BeFree,GAD,LHGDN Detail
0.128 myeloid leukemia NA BeFree,CTD_human,GAD Detail
0.003 Myeloid Leukemia, Chronic NA BeFree,GAD Detail
0.120 Liver diseases NA CTD_human Detail
0.003 Liver neoplasms NA BeFree,GAD Detail
<0.001 Lung diseases NA BeFree Detail
0.005 Chronic Obstructive Airway Disease NA GAD Detail
0.013 Lung Neoplasms NA BeFree,GAD,LHGDN Detail
0.003 lymphoma NA BeFree,GAD Detail
0.009 Lymphoma, Non-Hodgkin NA GAD Detail
0.001 Malignant neoplasm of stomach NA BeFree Detail
0.002 Marijuana Abuse NA GAD Detail
<0.001 melanoma NA BeFree Detail
<0.001 Mesothelioma NA BeFree Detail
<0.001 Metabolic Diseases Our data suggest that polymorphisms of HMOX1 and NQO1 genes are associated with ... BeFree 25933176 Detail
0.002 Metaplasia NA GAD Detail
<0.001 mitral valve stenosis NA BeFree Detail
0.005 Mouth Neoplasms NA GAD Detail
0.126 multiple myeloma NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 multiple sclerosis Combined GSTP1 and NQO1 germline polymorphisms in the susceptibility to Multiple... BeFree 24588223 Detail
<0.001 Myeloproliferative disease NA BeFree Detail
0.002 myocardial infarction NA GAD Detail
0.001 Neoplasm Metastasis Clinically, overexpression of the NFE2L2 target gene NQO1 in tumours was signifi... BeFree 25135868 Detail
0.002 Neoplasm Recurrence, Local NA GAD Detail
0.120 Neoplasms, Experimental NA CTD_human Detail
0.001 neuroblastoma NA BeFree Detail
<0.001 Spots on skin Genotyping for glutathione S-transferase micro1 (GSTM1), glutathione S-transfera... BeFree 14716779 Detail
<0.001 Nevus NA BeFree Detail
<0.001 Exanthema Genotyping for glutathione S-transferase micro1 (GSTM1), glutathione S-transfera... BeFree 14716779 Detail
<0.001 Melanocytic nevus NA BeFree Detail
0.120 obesity NA CTD_human Detail
0.125 Occupational Diseases NA CTD_human,GAD Detail
0.001 ovarian carcinoma High expression of NQO1 is associated with poor prognosis in serous ovarian carc... BeFree 25885439 Detail
0.006 Pancreatic Neoplasm NA BeFree,LHGDN Detail
0.120 papilloma NA CTD_human Detail
0.139 Parkinson disease NA CTD_human,GAD,LHGDN Detail
0.002 Peritoneal Neoplasms NA GAD Detail
0.005 Pharyngeal Neoplasms NA GAD Detail
0.002 Pregnancy Complications NA GAD Detail
<0.001 Preleukemia NA BeFree Detail
0.005 Prenatal Exposure Delayed Effects NA GAD Detail
0.123 Prostatic Neoplasms NA BeFree,CTD_human,LHGDN Detail
0.002 psoriasis NA GAD Detail
0.002 Psychoses, Substance-Induced NA GAD Detail
0.009 schizophrenia NA BeFree,GAD,LHGDN Detail
0.080 Seizures NA RGD Detail
<0.001 Septicemia NA BeFree Detail
0.002 Stomach Neoplasms NA GAD Detail
0.003 Cerebrovascular accident NA BeFree,GAD Detail
0.080 Subarachnoid Hemorrhage NA RGD Detail
<0.001 synovial sarcoma NA BeFree Detail
0.002 Thyroid Neoplasm NA GAD Detail
0.002 Trisomy NA GAD Detail
<0.001 Unipolar Depression NA BeFree Detail
0.080 ureteral obstruction NA RGD Detail
0.002 varicocele NA GAD Detail
<0.001 vitiligo NA BeFree Detail
0.005 Helicobacter Infections NA GAD Detail
0.003 diffuse large B-cell lymphoma NA BeFree,GAD Detail
0.002 T-Cell Lymphoma NA GAD Detail
0.002 Bronchial Hyperreactivity NA GAD Detail
0.005 Neoplasms, Second Primary NA GAD Detail
0.001 acute leukemia NA BeFree Detail
0.002 Alcohol abuse NA GAD Detail
0.004 Small cell carcinoma of lung In conclusion, NQO1 plays an important role in the progression of SCLC, and it m... BeFree,LHGDN 25231218 Detail
0.002 Premature Birth NA GAD Detail
0.002 Adenocarcinoma of lung (disorder) NA BeFree Detail
0.002 esophageal carcinoma NA BeFree Detail
0.001 lingual-facial-buccal dyskinesia NA BeFree Detail
0.005 Malignant neoplasm of brain NA GAD Detail
<0.001 Tumor Progression This study attempted to explore the role of NQO1 in tumor progression and progno... BeFree 25880877 Detail
0.001 hepatoblastoma NA BeFree Detail
<0.001 cholangiocarcinoma NA BeFree Detail
<0.001 Melanoma, Amelanotic NA BeFree Detail
<0.001 adult brain tumor NA BeFree Detail
<0.001 diastrophic dysplasia NA BeFree Detail
0.120 Neurotoxicity Syndromes NA CTD_human Detail
<0.001 pancreatic carcinoma NA BeFree Detail
<0.001 Alcohol withdrawal syndrome NA BeFree Detail
0.002 Cancer of Nasopharynx NA GAD Detail
<0.001 Papillary thyroid carcinoma NA BeFree Detail
0.060 Malignant neoplasm of lung Interactive effect of smoking and NQO1 haplotypes on lung cancer risk. BeFree,GAD 25729241 Detail
0.060 Malignant neoplasm of lung The NQO1 protein showed a mainly cytoplasmic staining pattern in lung cancer cel... BeFree,GAD 25880877 Detail
0.002 Oxidative Stress NA GAD Detail
<0.001 Sepsis NA BeFree Detail
0.003 Childhood asthma NA BeFree,GAD Detail
<0.001 Gastric dysplasia NA BeFree Detail
<0.001 gastric adenocarcinoma NA BeFree Detail
<0.001 Malignant Childhood Neoplasm NA BeFree Detail
<0.001 Small cell lung cancer limited stage Clinical significance of NQO1 polymorphism and expression of p53, SOD2, PARP1 in... BeFree 25400754 Detail
0.004 Squamous cell carcinoma of esophagus NA BeFree,GAD Detail
<0.001 Adenocarcinoma Of Esophagus NA BeFree Detail
<0.001 cervical squamous cell carcinoma NA BeFree Detail
0.001 Solid tumour High expression of NQO1 is associated with many solid tumors including those aff... BeFree 25885439 Detail
<0.001 Adenocarcinoma of pancreas NA BeFree Detail
0.001 cervix carcinoma NA BeFree Detail
<0.001 Restenosis NA BeFree Detail
0.002 Atrophic NA GAD Detail
0.002 Malignant neoplasm of liver NA GAD Detail
<0.001 Malignant neoplasm of pancreas NA BeFree Detail
<0.001 Aplastic anemia, idiopathic NA BeFree Detail
<0.001 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
0.009 Malignant neoplasm of prostate These results reveal a molecular link between NQO1 expression and proinflammator... BeFree,GAD 25125658 Detail
<0.001 Hematologic Neoplasms NA BeFree Detail
<0.001 Non-alcoholic Fatty Liver Disease NA BeFree Detail
<0.001 Chromosome 8, trisomy NA BeFree Detail
0.002 neuropathy NA GAD Detail
0.003 urolithiasis NA BeFree,GAD Detail
0.005 Mood Disorders NA BeFree,GAD,LHGDN Detail
0.011 Malignant neoplasm of esophagus NA BeFree,GAD Detail
<0.001 Thyroid carcinoma quinone oxidoreductase-1 (NQO1) is commonly elevated in various types of human c... BeFree 25231218 Detail
0.004 Carcinogenesis NQO1 suppresses NF-κB-p300 interaction to regulate inflammatory mediators associ... BeFree 25125658 Detail
<0.001 Leukemogenesis NA BeFree Detail
0.002 prostate carcinoma These results reveal a molecular link between NQO1 expression and proinflammator... BeFree 25125658 Detail
0.002 Manganese Poisoning NA GAD Detail
<0.001 Epithelial ovarian cancer High expression of NQO1 is associated with poor prognosis in serous ovarian carc... BeFree 25885439 Detail
0.007 breast carcinoma NQO1 expression variations in human breast cancer patient samples were noted, wh... BeFree 24512128 Detail
0.007 breast carcinoma Relationship of MTHFR and NQO1 Pharmacogenetics and Chemotherapy Clinical Outcom... BeFree 26014925 Detail
0.008 Carcinoma of lung Interactive effect of smoking and NQO1 haplotypes on lung cancer risk. BeFree 25729241 Detail
0.008 Carcinoma of lung The NQO1 protein showed a mainly cytoplasmic staining pattern in lung cancer cel... BeFree 25880877 Detail
<0.001 Malignant neoplasm of gastrointestinal tract NA BeFree Detail
0.001 Tardive Dyskinesia NA BeFree Detail
<0.001 Secondary malignant neoplasm of lymph node The rate of strong positive NQO1 protein expression was correlated with large tu... BeFree 25231218 Detail
<0.001 Secondary malignant neoplasm of lymph node The positive rate of NQO1 was related with clinical stage and lymph node metasta... BeFree 25880877 Detail
0.003 colon carcinoma NA BeFree Detail
0.002 stomach carcinoma NA BeFree Detail
0.001 Central neuroblastoma NA BeFree Detail
0.080 Infarction, Middle Cerebral Artery NA RGD Detail
<0.001 Malignant neoplasm of kidney NA BeFree Detail
<0.001 Premenopausal breast cancer NA BeFree Detail
<0.001 biliary tract cancer NA BeFree Detail
<0.001 Brain Tumor, Primary NA BeFree Detail
<0.001 Spots on skin NA BeFree Detail
<0.001 breast adenocarcinoma NA BeFree Detail
<0.001 Carcinogenicity NA BeFree Detail
<0.001 Ischemic stroke NA BeFree Detail
<0.001 Bone marrow toxicity NA BeFree Detail
0.002 Papillomavirus Infections NA GAD Detail
0.003 Malignant neoplasm of ovary NA BeFree,GAD Detail
<0.001 Squamous cell carcinoma of the head and neck NA BeFree Detail
<0.001 Ductal Carcinoma NA BeFree Detail
0.003 major depressive disorder NA BeFree,LHGDN Detail
0.001 Adenoma of large intestine NA BeFree Detail
<0.001 Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome NA BeFree Detail
<0.001 childhood leukemia NA BeFree Detail
<0.001 Carcinoma of urinary bladder, superficial NA BeFree Detail
<0.001 renal carcinoma NA BeFree Detail
<0.001 Benign melanocytic nevus NA BeFree Detail
0.134 Mammary Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 Skin Carcinogenesis NA BeFree Detail
0.034 colorectal cancer NA BeFree,GAD Detail
<0.001 Ductal Breast Carcinoma NA BeFree Detail
<0.001 Benign Prostatic Hyperplasia NA BeFree Detail
0.120 SPINOCEREBELLAR ATAXIA 17 NA CTD_human Detail
<0.001 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) NA BeFree Detail
0.003 coronary artery disease NA BeFree,GAD Detail
0.159 Precursor Cell Lymphoblastic Leukemia Lymphoma NA BeFree,CTD_human,GAD,LHGDN Detail
0.008 liver carcinoma Association between the NQO1 C609T polymorphism with hepatocellular carcinoma ri... BeFree,GAD,LHGDN 25773831 Detail
<0.001 Treatment related leukaemia NA BeFree Detail
<0.001 Ischemic Cerebrovascular Accident NA BeFree Detail
0.005 myelodysplastic syndrome NA BeFree,GAD Detail
<0.001 Triple Negative Breast Neoplasms Tumor-selective, futile redox cycle-induced bystander effects elicited by NQO1 b... BeFree 24512128 Detail
<0.001 Experimental Organism Basal Cell Carcinoma NA BeFree Detail
0.015 adenocarcinoma NA BeFree,GAD,LHGDN Detail
0.016 adenoma NA BeFree,GAD,LHGDN Detail
0.010 Alzheimer's disease NA BeFree,GAD Detail
<0.001 anemia We found significant association of variant genotype (TT) of NQO1 609C>T with gr... BeFree 26014925 Detail
<0.001 aplastic anemia NA BeFree Detail
0.002 Aneuploidy NA GAD Detail
0.002 Angina Pectoris NA GAD Detail
<0.001 arteriosclerosis NA BeFree Detail
0.136 asthma NA BeFree,CTD_human,GAD Detail
0.003 atherosclerosis NA BeFree,GAD Detail
0.003 Balkan nephropathy NA BeFree,GAD Detail
0.003 Barrett esophagus NA BeFree,LHGDN Detail
<0.001 Benign Ovarian Neoplasm NQO1 protein expression was assessed using immunohistochemical (IHC) staining in... BeFree 25885439 Detail
0.131 Bladder Neoplasm NA BeFree,CTD_human,GAD,LHGDN Detail
<0.001 Brain Neoplasms NA BeFree Detail
0.036 Malignant neoplasm of breast NQO1 expression variations in human breast cancer patient samples were noted, wh... BeFree,GAD 24512128 Detail
0.036 Malignant neoplasm of breast Relationship of MTHFR and NQO1 Pharmacogenetics and Chemotherapy Clinical Outcom... BeFree,GAD 26014925 Detail
<0.001 bronchopulmonary dysplasia In regression models that adjusted for epidemiological confounders, the NQO1 and... BeFree 25518008 Detail
0.008 Burkitt lymphoma NA GAD,LHGDN Detail
<0.001 Malignant tumor of colon NA BeFree Detail
<0.001 Adenocarcinoma of prostate NA BeFree Detail
<0.001 Malignant neoplasm of skin NA BeFree Detail
<0.001 Malignant neoplasm of thyroid quinone oxidoreductase-1 (NQO1) is commonly elevated in various types of human c... BeFree 25231218 Detail
<0.001 Noninfiltrating Intraductal Carcinoma NA BeFree Detail
0.124 Non-small cell lung carcinoma The NQO1 C609T polymorphism is an important molecular marker for advanced NSCLC,... BeFree,CTD_human 24464627 Detail
0.124 Non-small cell lung carcinoma Increased NQO1 but not c-MET and survivin expression in non-small cell lung carc... BeFree,CTD_human 25222473 Detail
0.124 Non-small cell lung carcinoma NQO1 protein expression predicts poor prognosis of non-small cell lung cancers. BeFree,CTD_human 25880877 Detail
0.002 Carcinoma, Papillary NA GAD Detail
Annotation

Annotations

DescrptionSourceLinks
NA DisGeNET Detail
The additive effect of smoking and the NQO1 C-T/C-T diplotype was more apparent in squamous cell car... DisGeNET Detail
The NQO1 protein showed a mainly cytoplasmic staining pattern in lung cancer cells, including adenoc... DisGeNET Detail
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This study was conducted to determine the association between arsenic exposure and polymorphisms of ... DisGeNET Detail
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The aim of this study was to examine the individual and interactive associations of five non-synonym... DisGeNET Detail
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Our data suggest that polymorphisms of HMOX1 and NQO1 genes are associated with a high risk of metab... DisGeNET Detail
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Combined GSTP1 and NQO1 germline polymorphisms in the susceptibility to Multiple Sclerosis. DisGeNET Detail
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Clinically, overexpression of the NFE2L2 target gene NQO1 in tumours was significantly associated wi... DisGeNET Detail
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Genotyping for glutathione S-transferase micro1 (GSTM1), glutathione S-transferase theta1 (GSTT1), m... DisGeNET Detail
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Genotyping for glutathione S-transferase micro1 (GSTM1), glutathione S-transferase theta1 (GSTT1), m... DisGeNET Detail
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High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma. DisGeNET Detail
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In conclusion, NQO1 plays an important role in the progression of SCLC, and it may potentially be us... DisGeNET Detail
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This study attempted to explore the role of NQO1 in tumor progression and prognostic evaluation of n... DisGeNET Detail
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Interactive effect of smoking and NQO1 haplotypes on lung cancer risk. DisGeNET Detail
The NQO1 protein showed a mainly cytoplasmic staining pattern in lung cancer cells, including adenoc... DisGeNET Detail
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Clinical significance of NQO1 polymorphism and expression of p53, SOD2, PARP1 in limited-stage small... DisGeNET Detail
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High expression of NQO1 is associated with many solid tumors including those affecting the colon, br... DisGeNET Detail
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These results reveal a molecular link between NQO1 expression and proinflammatory cytokine signaling... DisGeNET Detail
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quinone oxidoreductase-1 (NQO1) is commonly elevated in various types of human cancers, including pa... DisGeNET Detail
NQO1 suppresses NF-κB-p300 interaction to regulate inflammatory mediators associated with prostate t... DisGeNET Detail
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These results reveal a molecular link between NQO1 expression and proinflammatory cytokine signaling... DisGeNET Detail
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High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma. DisGeNET Detail
NQO1 expression variations in human breast cancer patient samples were noted, where ~60% cancers ove... DisGeNET Detail
Relationship of MTHFR and NQO1 Pharmacogenetics and Chemotherapy Clinical Outcomes in Breast Cancer ... DisGeNET Detail
Interactive effect of smoking and NQO1 haplotypes on lung cancer risk. DisGeNET Detail
The NQO1 protein showed a mainly cytoplasmic staining pattern in lung cancer cells, including adenoc... DisGeNET Detail
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The rate of strong positive NQO1 protein expression was correlated with large tumor size (P=0.019), ... DisGeNET Detail
The positive rate of NQO1 was related with clinical stage and lymph node metastasis, and the strongl... DisGeNET Detail
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Association between the NQO1 C609T polymorphism with hepatocellular carcinoma risk in the Chinese po... DisGeNET Detail
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Tumor-selective, futile redox cycle-induced bystander effects elicited by NQO1 bioactivatable radios... DisGeNET Detail
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We found significant association of variant genotype (TT) of NQO1 609C>T with grade 2-4 toxicity [OR... DisGeNET Detail
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NQO1 protein expression was assessed using immunohistochemical (IHC) staining in 160 patients with s... DisGeNET Detail
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NQO1 expression variations in human breast cancer patient samples were noted, where ~60% cancers ove... DisGeNET Detail
Relationship of MTHFR and NQO1 Pharmacogenetics and Chemotherapy Clinical Outcomes in Breast Cancer ... DisGeNET Detail
In regression models that adjusted for epidemiological confounders, the NQO1 and the NFE2L2 SNPs wer... DisGeNET Detail
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quinone oxidoreductase-1 (NQO1) is commonly elevated in various types of human cancers, including pa... DisGeNET Detail
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The NQO1 C609T polymorphism is an important molecular marker for advanced NSCLC, since it is associa... DisGeNET Detail
Increased NQO1 but not c-MET and survivin expression in non-small cell lung carcinoma with KRAS muta... DisGeNET Detail
NQO1 protein expression predicts poor prognosis of non-small cell lung cancers. DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386493716 dbSNP
Genome
hg19
Position
chr16:69,740,899-69,760,571
Variant Type
snv
Genome browser