chr9:120475302:A>G Detail (hg19) (TLR4)

Information

Genome

Assembly Position
hg19 chr9:120,475,302-120,475,302
hg38 chr9:117,713,024-117,713,024 View the variant detail on this assembly version.

HGVS

Type Transcript Protein
RefSeq NM_138554.4:c.896A>G NP_612564.1:p.Asp299Gly
NM_003266.3:c.776A>G NP_003257.1:p.Asp259Gly
Ensemble ENST00000355622.8:c.896A>G ENST00000355622.8:p.Asp299Gly
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

JP HGVD:0.002
ToMMo:[No Data.]
NCBN:[No Data.]
NCBN(Hondo):[No Data.]
NCBN(Ryukyu):[No Data.]
East asia ExAC:<0.001

Prediction

ClinVar

Clinical Significance Conflicting classifications of pathogenicity; protective
Review star
Show details
Links
Type Database ID Link
Gene MIM 603030 OMIM
HGNC 11850 HGNC
Ensembl ENSG00000136869 Ensembl
NCBI NCBI
Gene Cards Gene Cards
OncoKB OncoKB
Type Database ID Link
Variant TogoVar tgv37430566 TogoVar
COSMIC
MONDO
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
Clinical significance Last evaluated Review status Condition Origin Links
Benign 2007-09-01 no assertion criteria provided TLR4 POLYMORPHISM germline Detail
protective 2018-12-03 no assertion criteria provided Pericementitis somatic Detail
Uncertain significance no assertion criteria provided Susceptibility to severe coronavirus disease (COVID-19) germline Detail
Likely risk allele 2023-09-01 no assertion criteria provided COPD, severe early onset germline Detail
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.001 colorectal cancer A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
<0.001 ovarian carcinoma A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
0.006 colorectal carcinoma A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
0.004 ovarian carcinoma A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
0.010 Malignant neoplasm of ovary A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
<0.001 Malignant neoplasm of ovary A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
<0.001 ovarian carcinoma A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
0.002 colorectal carcinoma A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
0.004 colorectal carcinoma A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
0.017 colorectal cancer A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
0.003 colorectal carcinoma A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
0.003 Malignant neoplasm of ovary A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
0.005 colorectal cancer A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
0.001 Malignant neoplasm of ovary A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
0.007 stomach carcinoma A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
0.001 ovarian carcinoma A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
0.006 colorectal carcinoma A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
0.008 colorectal cancer A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
0.013 colorectal cancer A case-control study of 401 cases and 300 sex- and age-matched controls was perf... BeFree 24446182 Detail
0.017 tuberculosis Polymorphisms of the toll-like receptor 2 (TLR2) gene (Arg677Trp, Arg753Gln) and... BeFree 20002809 Detail
0.015 Diabetes Mellitus, Non-Insulin-Dependent In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gl... BeFree 23091345 Detail
0.010 Coronary Arteriosclerosis In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gl... BeFree 23091345 Detail
<0.001 Coronary Arteriosclerosis In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gl... BeFree 23091345 Detail
0.134 coronary artery disease In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gl... BeFree 23091345 Detail
<0.001 Mycobacterium Infections Nonconservative single nucleotide polymorphisms in the coding regions of TLR-2 (... BeFree 17855803 Detail
<0.001 Coronary heart disease In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gl... BeFree 23091345 Detail
0.002 Mycobacterium Infections Nonconservative single nucleotide polymorphisms in the coding regions of TLR-2 (... BeFree 17855803 Detail
0.006 Cytomegalovirus Infections Relationship between toll-like receptor 2 Arg677Trp and Arg753Gln and toll-like ... BeFree 24813591 Detail
0.001 Septicaemia due to gram-negative organism, unspecified Nonconservative single nucleotide polymorphisms in the coding regions of TLR-2 (... BeFree 17855803 Detail
0.002 Septicaemia due to gram-negative organism, unspecified Nonconservative single nucleotide polymorphisms in the coding regions of TLR-2 (... BeFree 17855803 Detail
0.008 Coronary heart disease In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gl... BeFree 23091345 Detail
0.051 tuberculosis Polymorphisms of the toll-like receptor 2 (TLR2) gene (Arg677Trp, Arg753Gln) and... BeFree 20002809 Detail
<0.001 coronary artery disease In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gl... BeFree 23091345 Detail
0.003 Cytomegalovirus Infections Relationship between toll-like receptor 2 Arg677Trp and Arg753Gln and toll-like ... BeFree 24813591 Detail
<0.001 Diabetes Mellitus, Non-Insulin-Dependent In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gl... BeFree 23091345 Detail
0.003 obesity In our study, TNF-alpha, soluble TNF receptor 1 (sTNFR1), and soluble TNF recept... BeFree 20357716 Detail
0.015 Tuberculosis, Pulmonary In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile... BeFree 20797905 Detail
<0.001 Tuberculosis, Pulmonary In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile... BeFree 20797905 Detail
0.012 Tuberculosis, Pulmonary In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile... BeFree 20797905 Detail
0.002 Tuberculosis, Pulmonary In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile... BeFree 20797905 Detail
0.001 Tuberculosis, Pulmonary In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile... BeFree 20797905 Detail
0.201 Aortic Aneurysm, Thoracic Interestingly, the rs4986790 TLR4 polymorphism confers a higher susceptibility f... BeFree 25120286 Detail
0.201 Aortic Aneurysm, Thoracic Interestingly, the rs4986790 TLR4 polymorphism confers a higher susceptibility f... BeFree 25120286 Detail
<0.001 Aortic Aneurysm, Thoracic Interestingly, the rs4986790 TLR4 polymorphism confers a higher susceptibility f... BeFree 25120286 Detail
<0.001 candidiasis Single-nucleotide polymorphisms in three innate immune genes were associated wit... BeFree 24557424 Detail
<0.001 Organ dysfunction syndrome We evaluated the role of single nucleotide polymorphisms for five genes: bacteri... BeFree 24383711 Detail
<0.001 Organ dysfunction syndrome We evaluated the role of single nucleotide polymorphisms for five genes: bacteri... BeFree 24383711 Detail
<0.001 Organ dysfunction syndrome We evaluated the role of single nucleotide polymorphisms for five genes: bacteri... BeFree 24383711 Detail
<0.001 Organ dysfunction syndrome We evaluated the role of single nucleotide polymorphisms for five genes: bacteri... BeFree 24383711 Detail
<0.001 Organ dysfunction syndrome We evaluated the role of single nucleotide polymorphisms for five genes: bacteri... BeFree 24383711 Detail
0.006 bacterial vaginosis Two SNPs were associated with BV as diagnosed by the Nugent score and the combin... BeFree 23021866 Detail
0.005 gastritis We investigated the allelic frequencies of TLR4 (D299G and T399I) and NOD2/CARD1... BeFree 20332463 Detail
0.014 gastritis We investigated the allelic frequencies of TLR4 (D299G and T399I) and NOD2/CARD1... BeFree 20332463 Detail
0.560 Crohn Disease To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (... BeFree 18680223 Detail
0.034 ulcerative colitis To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (... BeFree 18680223 Detail
0.183 Crohn Disease To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (... BeFree 18680223 Detail
0.008 Coronary heart disease The TLR4/Asp299Gly and CD14/C-260T polymorphisms and plasma sCD14 concentrations... BeFree 15367917 Detail
0.136 age related macular degeneration Even with previously verified samples sets and adequate study powers, the result... BeFree 19628747 Detail
0.012 age related macular degeneration Even with previously verified samples sets and adequate study powers, the result... BeFree 19628747 Detail
<0.001 rheumatoid arthritis The Mal S180L and TLR4 G299D polymorphisms do not contribute to RA susceptibilit... BeFree 18180278 Detail
0.013 malaria The tlr-4 (D299G and T399I), tlr-9 (T-1486C and T-1237C) and tirap (S180L) genes... BeFree 21457584 Detail
0.016 malaria The tlr-4 (D299G and T399I), tlr-9 (T-1486C and T-1237C) and tirap (S180L) genes... BeFree 21457584 Detail
0.154 asthma Decreased LPS-induced IL-12(p70) and IL-10 responses were associated with the TL... BeFree 15356557 Detail
<0.001 Spondylarthropathies Lack of genetic association of the Toll-like receptor 4 (TLR4) Asp299Gly and Thr... BeFree 16567359 Detail
0.015 stomach carcinoma Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -2... BeFree 17462092 Detail
0.006 Chlamydia Infections The Arg753Gln TLR2 and Asp299Gly TLR4 polymorphisms were not related to chlamydi... BeFree 15175649 Detail
0.008 Coronary heart disease The findings of this study do not support the hypothesis that the TLR4 Asp299Gly... BeFree 12957699 Detail
<0.001 Chronic gastritis TLR-4 Asp299Gly G allele substitution may be modified pattern of immune response... BeFree 24508388 Detail
0.010 Septicemia Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) hav... BeFree 18034244 Detail
0.158 atherosclerosis The purpose of this study was to investigate the role of a common Asp299Gly poly... BeFree 17101559 Detail
0.010 Septicemia Our study investigated the association between TLR4 mutations (Asp299Gly and Thr... BeFree 12404174 Detail
0.015 Diabetes Mellitus, Non-Insulin-Dependent Toll-like receptor 4 gene Asp299Gly and Thr399Ile polymorphisms in type 2 diabet... BeFree 25648392 Detail
<0.001 Carotid Atherosclerosis A total of 3000 individuals from the prospective community-based Carotid Atheros... BeFree 17332447 Detail
0.002 Inflammatory Bowel Diseases The c.1-260C&gt;T promoter variant of CD14 but not the c.896A&gt;G (p.D299G) var... BeFree 18174680 Detail
0.134 coronary artery disease We studied the TLR4 gene Asp299Gly polymorphism in relation to susceptibility to... BeFree 15864121 Detail
<0.001 Candidemia IL-10 production was higher in C. albicans-stimulated PBMC from volunteers beari... BeFree 16613760 Detail
0.017 periodontitis We screened 197 individuals suffering from generalized periodontitis for the pre... BeFree 15875057 Detail
<0.001 cervix carcinoma However, the C/C genotype for the TLR3 (c.1377 C&gt;T) polymorphism and the Asp/... BeFree 25373689 Detail
0.003 familial Mediterranean fever TLR polymorphisms in FMF: association of TLR-2 (Arg753Gln) and TLR-4 (Asp299Gly,... BeFree 20714796 Detail
0.003 Transient ischemic attack We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF... BeFree 16879054 Detail
0.012 Bacterial Infections Toll-like receptor 4 D299G polymorphism could influence not only the predisposit... BeFree 20222908 Detail
0.058 asthma Determination of the TLR4 Asp299Gly/Thr399Ile haplotype is of no clinical benefi... BeFree 20711470 Detail
0.183 Crohn Disease The Toll-like receptor 4 D299G and T399I polymorphisms are associated with Crohn... BeFree 20093834 Detail
<0.001 hemorrhagic cystitis In conclusion, the TLR4 Asp299Gly variant seems to confer protection against hem... BeFree 22300618 Detail
0.001 Malignant tumor of cervix However, the C/C genotype for the TLR3 (c.1377 C&gt;T) polymorphism and the Asp/... BeFree 25373689 Detail
0.080 Transient ischemic attack We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF... BeFree 16879054 Detail
0.009 Malignant neoplasm of stomach TLR4/D299G/T399I polymorphisms were more frequent in duodenal ulcer and showed a... BeFree 18755634 Detail
0.004 colorectal carcinoma Positive link between variant Toll-like receptor 4 (Asp299Gly and Thr399Ile) and... BeFree 23949880 Detail
<0.001 peritonitis TLR4 A896G polymorphism (rs4986790) is a functional polymorphism resulting in hy... BeFree 21214494 Detail
0.005 Septicemia Our study investigated the association between TLR4 mutations (Asp299Gly and Thr... BeFree 12404174 Detail
0.011 sarcoidosis Recently, an association between TLR-4 polymorphism Asp299Gly, leading to a chan... BeFree 16879239 Detail
0.012 Bacterial Infections Polymorphisms in TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes are asso... BeFree 16487238 Detail
0.001 Vascular inflammations Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions i... BeFree 15632890 Detail
<0.001 vitiligo Our findings suggest that Toll-like receptor 2 gene Arg753Gln and Toll-like rece... BeFree 22429552 Detail
0.010 Coronary Arteriosclerosis Two polymorphisms of the TLR4 gene (Asp299Gly and Thr399Ile) were determined in ... BeFree 12742999 Detail
0.013 arteriosclerosis In summary, results in our study do not support the hypothesis that the rs498679... BeFree 22360682 Detail
<0.001 eclampsia Common SNPs of the TLR2 (Arg753Gln) and co-segregating TLR4 (Asp299Gly and Thr39... BeFree 20818954 Detail
0.001 Periodontal Diseases Genotyping for the TLR4 single-nucleotide polymorphisms (SNPs) Asp299Gly, Thr399... BeFree 17309585 Detail
0.001 Ischemic Cerebrovascular Accident Toll-like receptor 4 gene C119A but not Asp299Gly polymorphism is associated wit... BeFree 15910856 Detail
0.003 typhoid fever Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and typhoid susceptib... BeFree 21612766 Detail
<0.001 Severe Sepsis Two common SNPs of the TLR2 and TLR4 genes--Arg753Gln and Asp299Gly--were associ... BeFree 24366499 Detail
0.034 Inflammatory Bowel Diseases Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) hav... BeFree 18034244 Detail
0.010 ankylosing spondylitis No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C2... BeFree 15647432 Detail
0.012 Bacterial Infections Two single nucleotide polymorphisms (SNPs) encoding Asp299Gly and Thr399Ile subs... BeFree 17709532 Detail
0.044 Malignant neoplasm of stomach Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -2... BeFree 17462092 Detail
0.013 arteriosclerosis The G allele of the Toll-like receptor 4 (TLR-4) gene Asp299Gly polymorphism has... BeFree 17996871 Detail
0.021 myocardial infarction Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocard... BeFree 17493663 Detail
0.183 Crohn Disease The TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped and tested for cas... BeFree 17850411 Detail
0.003 Neonatal disorder We initiated a pilot study in preterm children to determine the prevalence of si... BeFree 16967363 Detail
0.004 colorectal carcinoma In conclusion, we report an association of microsatelite GT polymorphisms of TLR... BeFree 16879199 Detail
0.004 coronary artery disease We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs ... BeFree 15632890 Detail
0.005 Malignant neoplasm of stomach Our data suggest that CD14 promoter-159TT and T carrier were associated with low... BeFree 19847953 Detail
<0.001 neuropathy Two specific polymorphisms of toll-like receptor 4 (TLR4; Asp299Gly and Thr399Il... BeFree 21628510 Detail
0.058 asthma Wherease some previous studies indicated TLRs and their polymorphisms might have... BeFree 25530138 Detail
0.134 coronary artery disease TLR4 gene polymorphism (Asp299Gly) attenuates innate immune responsiveness, redu... BeFree 19273219 Detail
0.003 Hay fever Our objective was to determine the frequency of TNF-alpha -238, -308 G/A promote... BeFree 21103885 Detail
0.167 coronary artery disease We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs ... BeFree 15632890 Detail
0.002 cerebral infarction This study was aimed to detect two commonly reported Asp299Gly and Thr399Ile pol... BeFree 20504212 Detail
0.013 arteriosclerosis Lack of association between TLR4 Asp299Gly polymorphism and atherosclerosis: evi... BeFree 22857799 Detail
0.560 Crohn Disease The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD1... BeFree 15973118 Detail
0.010 Coronary Arteriosclerosis The findings of this study do not support the hypothesis that the TLR4 Asp299Gly... BeFree 12957699 Detail
0.012 Cardiovascular Diseases Lack of association between TLR4 rs4986790 polymorphism and risk of cardiovascul... BeFree 22360682 Detail
0.007 stomach carcinoma Based on our meta-analysis, the TLR signalling pathway is involved in gastric ca... BeFree 23565226 Detail
0.027 rheumatoid arthritis The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR... BeFree 18381796 Detail
0.001 Gingival Diseases Genotyping for the TLR4 single-nucleotide polymorphisms (SNPs) Asp299Gly, Thr399... BeFree 17309585 Detail
<0.001 Active tuberculosis We found a greater risk of developing active tuberculosis as well as a reduction... BeFree 17545720 Detail
0.014 gastritis Association of Toll-like receptor-4 (Asp299Gly and Thr399Ileu) gene polymorphism... BeFree 18082569 Detail
0.013 arteriosclerosis 1400 participants (mean age: 63 years, 31% female) in the Southampton Atheroscle... BeFree 12957699 Detail
<0.001 ankylosing spondylitis No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C2... BeFree 15647432 Detail
0.004 diabetes mellitus Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions i... BeFree 15632890 Detail
0.005 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site Toll-like receptor 4 Asp299Gly polymorphism in respiratory syncytial virus epide... BeFree 20575099 Detail
0.021 myocardial infarction Toll-like receptor 4 gene Asp299Gly polymorphism in myocardial infarction: a met... BeFree 24269693 Detail
0.021 HIV Infections The toll-like receptor 4 Asp299Gly variant and tuberculosis susceptibility in HI... BeFree 17545720 Detail
0.017 tuberculosis The toll-like receptor 4 Asp299Gly variant and tuberculosis susceptibility in HI... BeFree 17545720 Detail
<0.001 ankylosing spondylitis No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C2... BeFree 15647432 Detail
0.183 Crohn Disease The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD1... BeFree 15973118 Detail
0.021 HIV Infections We describe an independent association between TLR4 Asp299Gly SNP and active TB ... BeFree 20226000 Detail
0.002 Diabetes Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions i... BeFree 15632890 Detail
0.027 rheumatoid arthritis Our overall analyses indicated that TLR4 Asp299Gly polymorphism might contribute... BeFree 25499175 Detail
0.010 Coronary Arteriosclerosis Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions i... BeFree 15632890 Detail
0.002 Carotid Atherosclerosis This implies that the Asp299Gly TLR4-allele might have a protective role in caro... BeFree 15258789 Detail
0.005 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site The aim of this study was to investigate the possible role of polymorphisms of T... BeFree 25572736 Detail
0.034 ulcerative colitis The TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped and tested for cas... BeFree 17850411 Detail
<0.001 Reactive systemic amyloidosis TLR polymorphisms in FMF: association of TLR-2 (Arg753Gln) and TLR-4 (Asp299Gly,... BeFree 20714796 Detail
<0.001 allergic asthma Decreased LPS-induced IL-12(p70) and IL-10 responses were associated with the TL... BeFree 15356557 Detail
0.002 Diabetes The Asp299Gly polymorphism in TLR4 was associated with increased insulin, homeos... BeFree 21306745 Detail
0.005 Chagas Cardiomyopathy In contrast, the heterozygous Toll-like receptor 4 (TLR4)-deficiency genotype D2... BeFree 22302853 Detail
<0.001 Active tuberculosis The TLR4 ASP299GLY polymorphism is a risk factor for active tuberculosis in Cauc... BeFree 20226000 Detail
0.002 Cirrhosis The present study aimed to investigate the association between TLR4 mutations (A... BeFree 18666712 Detail
0.005 Septicemia Our study investigated the association between TLR4 mutations (Asp299Gly and Thr... BeFree 12404174 Detail
0.025 Bacterial Infections Polymorphisms in TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes are asso... BeFree 16487238 Detail
<0.001 Transient ischemic attack We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF... BeFree 16879054 Detail
0.244 Sepsis Our study investigated the association between TLR4 mutations (Asp299Gly and Thr... BeFree 12404174 Detail
0.013 arteriosclerosis The purpose of this study was to investigate the role of a common Asp299Gly poly... BeFree 17101559 Detail
0.034 ulcerative colitis The Toll-like receptor 4 D299G and T399I polymorphisms are associated with Crohn... BeFree 20093834 Detail
0.134 coronary artery disease The findings of this study do not support the hypothesis that the TLR4 Asp299Gly... BeFree 12957699 Detail
0.034 ulcerative colitis We have reported on a novel association of the TLR4 Asp299Gly polymorphism with ... BeFree 15194649 Detail
0.244 Sepsis Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) hav... BeFree 18034244 Detail
0.002 stomach carcinoma The association between Toll-like receptor 2 (TLR2) -196 to -174del polymorphism... BeFree 24007538 Detail
<0.001 eclampsia Common SNPs of the TLR2 (Arg753Gln) and co-segregating TLR4 (Asp299Gly and Thr39... BeFree 20818954 Detail
0.003 Fibrosis, Liver At stepwise logistic regression analysis, the carriage of TLR-4 rs4986790 A/A ge... BeFree 23093310 Detail
<0.001 Acute Cerebrovascular Accidents We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF... BeFree 16879054 Detail
0.005 hepatitis C The effect of TLR4 D299G on long-term graft survival was analyzed based on hepat... BeFree 20400193 Detail
0.008 Coronary heart disease We studied the TLR4 gene Asp299Gly polymorphism in relation to susceptibility to... BeFree 15864121 Detail
0.124 Endotoxin Hyporesponsiveness In support of this idea, we have recently demonstrated that lung recipients hete... BeFree 15640363 Detail
0.158 atherosclerosis The Asp299Gly TLR4 polymorphism, which attenuates receptor signaling and diminis... BeFree 12124407 Detail
<0.001 osteomyelitis Polymorphisms in TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes are asso... BeFree 16487238 Detail
<0.001 Bronchopulmonary Aspergillosis A significant association was observed between allele G on Asp299Gly (TLR4) and ... BeFree 18275280 Detail
0.002 stomach carcinoma Based on our meta-analysis, the TLR signalling pathway is involved in gastric ca... BeFree 23565226 Detail
0.021 myocardial infarction The association of the D299G polymorphism of the TLR-4 gene with the progression... BeFree 15953129 Detail
<0.001 Nasopharyngeal carcinoma The aim of this study was to investigate the association of TLR2 R753Q, TLR4 D29... BeFree 22320262 Detail
0.008 Coronary heart disease A polymorphism of the TLR4 gene, Asp299Gly, is associated with an increased risk... BeFree 15910856 Detail
0.043 Sepsis Our study investigated the association between TLR4 mutations (Asp299Gly and Thr... BeFree 12404174 Detail
0.004 pneumonia Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were i... BeFree 25427560 Detail
0.014 gastritis TLR-4 Asp299Gly G allele substitution may be modified pattern of immune response... BeFree 24508388 Detail
<0.001 Pancolitis The presence of TLR-4 Asp299Gly and TLR-4 Thr399Ile polymorphisms is related to ... BeFree 22918682 Detail
0.006 duodenal ulcer TLR4/D299G/T399I polymorphisms were more frequent in duodenal ulcer and showed a... BeFree 18755634 Detail
0.001 diabetic retinopathy Two specific polymorphisms of toll-like receptor 4 (TLR4; Asp299Gly and Thr399Il... BeFree 21628510 Detail
0.010 Septicemia In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and T... BeFree 21968286 Detail
<0.001 Hypercholesterolemia, Familial Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of at... BeFree 14764071 Detail
0.007 stomach carcinoma We investigated the effects of common polymorphisms of TLR4 Asp299Gly, Thr399Ile... BeFree 19326213 Detail
0.001 Gingival Diseases Genotyping for the TLR4 single-nucleotide polymorphisms (SNPs) Asp299Gly, Thr399... BeFree 17309585 Detail
0.080 Transient ischemic attack We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF... BeFree 16879054 Detail
0.007 stomach carcinoma Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -2... BeFree 17462092 Detail
0.002 acute myocardial infarction Recently, the common Asp299Gly polymorphism of the Toll-like receptor 4 (TLR-4) ... BeFree 17587646 Detail
0.203 Diabetic Neuropathies Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced... BeFree 14693986 Detail
0.026 Lupus Erythematosus, Systemic Association of TLR4 (D299G, T399I), TLR9 -1486T&gt;C, TIRAP S180L and TNF-α prom... BeFree 25182168 Detail
<0.001 osteomyelitis The Toll-like receptor 4 (Asp299Gly) polymorphism is a risk factor for Gram-nega... BeFree 16487238 Detail
0.001 Gingival Diseases Genotyping for the TLR4 single-nucleotide polymorphisms (SNPs) Asp299Gly, Thr399... BeFree 17309585 Detail
0.006 Periodontal Diseases Genotyping for the TLR4 single-nucleotide polymorphisms (SNPs) Asp299Gly, Thr399... BeFree 17309585 Detail
0.124 Neoplasm Metastasis An improved overall survival (Hazard ratio HR 0.53, 95% CI 0.32-0.88) and surviv... BeFree 21931695 Detail
0.006 Periodontal Diseases Therefore, the aim of this study was to investigate the association between the ... BeFree 23879541 Detail
0.003 stomach carcinoma Our data suggest that CD14 promoter-159TT and T carrier were associated with low... BeFree 19847953 Detail
0.244 Sepsis [Candidate single nucleotide polymorphisms (SNPs) within bacterial recognition (... GAD 15520404 Detail
<0.001 Vascular inflammations We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs ... BeFree 15632890 Detail
0.012 Diabetes Mellitus, Insulin-Dependent Our data indicate that Asp299Gly and Thr399Ile genotypes of the TLR4 gene are as... BeFree 14693986 Detail
0.183 Crohn Disease In this two-center, retrospective German and Hungarian cohort study, patients wi... BeFree 18174680 Detail
0.034 ulcerative colitis TLR4 D299G polymorphism modulates cytokine expression in ulcerative colitis. BeFree 23470644 Detail
<0.001 Acute Cerebrovascular Accidents We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF... BeFree 16879054 Detail
0.080 Diabetes TLR4(D299G/T399I) associates with increased total body fat, visceral fat, liver ... BeFree 21125016 Detail
<0.001 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) Our findings suggest that Toll-like receptor 2 gene Arg753Gln and Toll-like rece... BeFree 22429552 Detail
<0.001 Acute Cerebrovascular Accidents We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF... BeFree 16879054 Detail
0.010 liver cirrhosis The present study aimed to investigate the association between TLR4 mutations (A... BeFree 18666712 Detail
0.034 ulcerative colitis The presence of TLR-4 Asp299Gly and TLR-4 Thr399Ile polymorphisms is related to ... BeFree 22918682 Detail
0.017 tuberculosis Lack of association between Toll-like receptor 4 gene Asp299Gly and Thr399Ile po... BeFree 23200920 Detail
<0.001 Malignant tumor of cervix However, the C/C genotype for the TLR3 (c.1377 C&gt;T) polymorphism and the Asp/... BeFree 25373689 Detail
0.012 multiple sclerosis Impact of the Asp299Gly polymorphism in the toll-like receptor 4 (tlr-4) gene on... BeFree 15932772 Detail
0.034 ulcerative colitis Overall, no heterozygous or homozygous single nucleotide polymorphism mutations ... BeFree 23239925 Detail
0.031 periodontitis We screened 197 individuals suffering from generalized periodontitis for the pre... BeFree 15875057 Detail
0.183 Crohn Disease Toll-like receptor (TLR) polymorphisms, and especially TLR-4 Asp299Gly and TLR-4... BeFree 22918682 Detail
0.010 Coronary Arteriosclerosis We studied the TLR4 gene Asp299Gly polymorphism in relation to susceptibility to... BeFree 15864121 Detail
0.003 Fibrosis, Liver TLR4 D299G and T399I SNPs that are associated with protection from hepatic fibro... BeFree 19085953 Detail
<0.001 Liver failure The study included nine patients with cirrhosis and TLR4 D299G and/or T399I poly... BeFree 25516666 Detail
<0.001 Tumor necrosis To conclude, TLR4 D299G increases the risk for SLE, while TNF-α CCC haplotype re... BeFree 25182168 Detail
0.009 Malignant neoplasm of stomach Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -2... BeFree 17462092 Detail
0.002 Secondary malignant neoplasm of lymph node Positive link between variant Toll-like receptor 4 (Asp299Gly and Thr399Ile) and... BeFree 23949880 Detail
0.034 Inflammatory Bowel Diseases The c.1-260C&gt;T promoter variant of CD14 but not the c.896A&gt;G (p.D299G) var... BeFree 18174680 Detail
0.002 Carotid Atherosclerosis A total of 3000 individuals from the prospective community-based Carotid Atheros... BeFree 17332447 Detail
0.006 Carcinogenesis Caco-2 cells that expressed TLR4-D299G had significant increases in expression l... BeFree 21920464 Detail
0.002 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site However, we detected that A allele carriers of the TLR4 Asp299Gly polymorphism m... BeFree 24007538 Detail
<0.001 Acute Cerebrovascular Accidents We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF... BeFree 16879054 Detail
0.158 atherosclerosis Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of at... BeFree 14764071 Detail
0.001 Gingival Diseases Therefore, the aim of this study was to investigate the association between the ... BeFree 23879541 Detail
<0.001 Metabolic Diseases Toll-like receptor 4 D299G polymorphism in metabolic disorders: a meta-analysis. BeFree 23275193 Detail
0.010 Septicemia Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were i... BeFree 25427560 Detail
0.005 Sepsis Our study investigated the association between TLR4 mutations (Asp299Gly and Thr... BeFree 12404174 Detail
0.002 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site A Toll-like receptor-4 (TLR-4) Asp299Gly and Thr399Ileu substitution reduces res... BeFree 18082569 Detail
0.004 coronary artery disease We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs ... BeFree 15632890 Detail
0.015 Diabetes Mellitus, Non-Insulin-Dependent Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced... BeFree 14693986 Detail
0.008 colorectal cancer In conclusion, we report an association of microsatelite GT polymorphisms of TLR... BeFree 16879199 Detail
0.005 hepatitis B Toll like receptor 4 D299G associates with disease progression in Caucasian pati... BeFree 23093310 Detail
0.003 Pulmonary Aspergillosis A significant association was observed between allele G on Asp299Gly (TLR4) and ... BeFree 18275280 Detail
0.003 breast carcinoma The -174 to -196del of TLR2 gene and Asp299Gly of TLR4 gene polymorphisms may co... BeFree 22560646 Detail
0.006 adenocarcinoma Expression of STAT3 messenger RNA was higher among colonic adenocarcinomas with ... BeFree 21920464 Detail
0.004 acute pancreatitis Toll-like receptor 4 Asp299Gly polymorphism is associated with an increased risk... BeFree 17414051 Detail
0.158 atherosclerosis For this purpose we investigated the prevalence and any possible associations of... BeFree 20169003 Detail
0.002 stomach carcinoma Our data suggest that CD14 promoter-159TT and T carrier were associated with low... BeFree 19847953 Detail
0.183 Crohn Disease To examine whether TLR4 Asp299Gly, CD14-260C/T, TNF-1031T/C, TNF-863C/A, TNF-857... BeFree 18493210 Detail
0.002 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site The aim of this study was to investigate the possible role of polymorphisms of T... BeFree 25572736 Detail
0.158 atherosclerosis 1400 participants (mean age: 63 years, 31% female) in the Southampton Atheroscle... BeFree 12957699 Detail
0.031 Crohn Disease In this two-center, retrospective German and Hungarian cohort study, patients wi... BeFree 18174680 Detail
0.027 rheumatoid arthritis Lack of association of TLR4 gene Asp299Gly and Thr399Ile polymorphisms with rheu... BeFree 20306049 Detail
0.121 Lupus Erythematosus, Systemic Association of TLR4 (D299G, T399I), TLR9 -1486T&gt;C, TIRAP S180L and TNF-α prom... BeFree 25182168 Detail
0.295 diabetes mellitus TLR4(D299G/T399I) associates with increased total body fat, visceral fat, liver ... BeFree 21125016 Detail
0.005 hepatitis B By use of a polymerase chain reaction-based restriction fragment length polymorp... BeFree 18666712 Detail
0.021 myocardial infarction We evaluated the TLR4 D299G polymorphism among 695 individuals with incident myo... BeFree 15576653 Detail
0.008 Coronary heart disease TLR4 gene polymorphism (Asp299Gly) attenuates innate immune responsiveness, redu... BeFree 19273219 Detail
0.134 coronary artery disease Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions i... BeFree 15632890 Detail
0.010 Septicemia Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated wit... BeFree 25454804 Detail
0.013 arteriosclerosis Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of at... BeFree 14764071 Detail
0.003 Crohn Disease To examine whether TLR4 Asp299Gly, CD14-260C/T, TNF-1031T/C, TNF-863C/A, TNF-857... BeFree 18493210 Detail
0.004 cervix carcinoma However, the C/C genotype for the TLR3 (c.1377 C&gt;T) polymorphism and the Asp/... BeFree 25373689 Detail
0.001 squamous cell carcinoma Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in ... BeFree 21854645 Detail
0.002 Vascular inflammations We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs ... BeFree 15632890 Detail
0.005 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site This study genotyped 2 TLR4 mutations, Asp299Gly and Thr399Ile, and 2 single-nuc... BeFree 17471431 Detail
0.136 age related macular degeneration Toll-like receptor 4 variant D299G is associated with susceptibility to age-rela... BeFree 15829498 Detail
0.002 Malignant neoplasm of stomach Our data suggest that CD14 promoter-159TT and T carrier were associated with low... BeFree 19847953 Detail
0.009 Malignant neoplasm of stomach Our data suggest that CD14 promoter-159TT and T carrier were associated with low... BeFree 19847953 Detail
0.124 Endotoxin Hyporesponsiveness A non-synonymous variant in the extracellular domain of TLR4 (G299D) has been sh... BeFree 18180278 Detail
<0.001 Arthritis, Gouty None polymorphisms of Asp299Gly and Thr399Ile were detected in all GA cases and ... BeFree 23152086 Detail
0.127 liver cirrhosis The present study aimed to investigate the association between TLR4 mutations (A... BeFree 18666712 Detail
0.005 Crohn Disease In this two-center, retrospective German and Hungarian cohort study, patients wi... BeFree 18174680 Detail
0.001 precancerous lesions Association of Toll-like receptor-4 (Asp299Gly and Thr399Ileu) gene polymorphism... BeFree 18082569 Detail
0.013 arteriosclerosis The Asp299Gly TLR4 polymorphism, which attenuates receptor signaling and diminis... BeFree 12124407 Detail
0.244 Sepsis Lack of association between TLR4 Asp299Gly and Thr399Ile polymorphisms and sepsi... BeFree 22537674 Detail
0.004 diabetes mellitus The Asp299Gly polymorphism in TLR4 was associated with increased insulin, homeos... BeFree 21306745 Detail
0.134 adenocarcinoma Expression of STAT3 messenger RNA was higher among colonic adenocarcinomas with ... BeFree 21920464 Detail
<0.001 Guillain-Barre syndrome Association of TLR4 Asp299Gly and Thr399Ile polymorphisms with Guillain-Barré sy... BeFree 19913922 Detail
0.124 Endotoxin Hyporesponsiveness NA CLINVAR Detail
0.007 stomach carcinoma The results of this meta-analysis indicate that the TLR4 Asp299Gly and Thr399Ile... BeFree 24007538 Detail
0.002 Carotid Atherosclerosis Recently, the common Asp299Gly polymorphism of the Toll-like receptor 4 (TLR-4) ... BeFree 17587646 Detail
0.129 Acute coronary syndrome These results, which must be confirmed by a prospective longitudinal study, prov... BeFree 14563652 Detail
0.008 Coronary heart disease Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions i... BeFree 15632890 Detail
0.006 Arthritis, Reactive Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms do not contribute to ... BeFree 16567359 Detail
<0.001 Vascular inflammations We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs ... BeFree 15632890 Detail
0.002 colon carcinoma Toll-like receptor 4 variant D299G induces features of neoplastic progression in... BeFree 21920464 Detail
<0.001 Malignant tumor of cervix Impact of Toll-like receptors [TLR] 2 (-196 to -174 del) and TLR 4 (Asp299Gly, T... BeFree 19541348 Detail
0.009 Malignant neoplasm of stomach The results of this meta-analysis indicate that the TLR4 Asp299Gly and Thr399Ile... BeFree 24007538 Detail
0.003 allergic asthma Decreased LPS-induced IL-12(p70) and IL-10 responses were associated with the TL... BeFree 15356557 Detail
<0.001 Cirrhosis The present study aimed to investigate the association between TLR4 mutations (A... BeFree 18666712 Detail
0.002 Carotid Atherosclerosis The Asp299Gly polymorphism in the toll-like receptor 4 (TLR4) gene reduces respo... BeFree 12957699 Detail
0.003 Helicobacter pylori infection To investigate toll-like receptor 2 (TLR2) -196 to -174 del, and TLR4 (+896A/G r... BeFree 22468087 Detail
0.124 Neoplasm Metastasis Human colon adenocarcinomas from patients with TLR4-D299G were more frequently o... BeFree 21920464 Detail
0.002 Diabetes TLR4(D299G/T399I) associates with increased total body fat, visceral fat, liver ... BeFree 21125016 Detail
0.003 cervix carcinoma Impact of Toll-like receptors [TLR] 2 (-196 to -174 del) and TLR 4 (Asp299Gly, T... BeFree 19541348 Detail
0.058 asthma Role of TLR4 C&gt;1196T (Thr399Ile) and TLR4 A&gt;896G (Asp299Gly) polymorphisms... BeFree 25331070 Detail
0.002 Tumor Progression Toll-like receptor 4 variant D299G induces features of neoplastic progression in... BeFree 21920464 Detail
<0.001 Acute Cerebrovascular Accidents We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF... BeFree 16879054 Detail
0.005 hepatitis C In a bivariate analysis several variables resulted significantly associated with... BeFree 20226000 Detail
0.014 Periodontal Diseases Genotyping for the TLR4 single-nucleotide polymorphisms (SNPs) Asp299Gly, Thr399... BeFree 17309585 Detail
<0.001 measles May TLR4 Asp299Gly and IL17 His161Arg polymorphism be associated with progressio... BeFree 24690400 Detail
0.001 Malignant tumor of colon Toll-like receptor 4 variant D299G induces features of neoplastic progression in... BeFree 21920464 Detail
0.004 diabetes mellitus TLR4(D299G/T399I) associates with increased total body fat, visceral fat, liver ... BeFree 21125016 Detail
<0.001 Transient ischemic attack We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF... BeFree 16879054 Detail
0.002 Helicobacter pylori infection To investigate toll-like receptor 2 (TLR2) -196 to -174 del, and TLR4 (+896A/G r... BeFree 22468087 Detail
0.008 colorectal cancer Positive link between variant Toll-like receptor 4 (Asp299Gly and Thr399Ile) and... BeFree 23949880 Detail
0.031 periodontitis The prevalence of TLR2 Arp677Trp polymorphism seemed to be rather high, while th... BeFree 18618036 Detail
0.010 Chronic Periodontitis It is concluded that in West European Caucasians, the Asp299Gly TLR4 gene polymo... BeFree 17309585 Detail
0.002 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site The aim of this study was to investigate the possible role of polymorphisms of T... BeFree 25572736 Detail
<0.001 breast carcinoma The -174 to -196del of TLR2 gene and Asp299Gly of TLR4 gene polymorphisms may co... BeFree 22560646 Detail
0.006 Virus Diseases Polymorphisms of the toll-like receptor (TLR) 2 (Arg677Trp, Arg753Gln) and TLR4 ... BeFree 21443084 Detail
0.027 rheumatoid arthritis This meta-analysis shows lack of an association between the TLR4 Asp299Gly polym... BeFree 23325096 Detail
0.002 Carotid Atherosclerosis The presence of the D299G and T399I polymorphisms of the TLR-4 gene does not pla... BeFree 15953129 Detail
0.005 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsive... BeFree 20711470 Detail
0.012 Tuberculosis, Pulmonary The toll-like receptor 4 Asp299Gly variant: no influence on LPS responsiveness o... BeFree 15525557 Detail
0.011 urinary tract infection In this study, we aimed to determine the relation of TLR-4 Asp299Gly and Thr399I... BeFree 23612767 Detail
0.006 Malignant neoplasm of breast The -174 to -196del of TLR2 gene and Asp299Gly of TLR4 gene polymorphisms may co... BeFree 22560646 Detail
0.244 Sepsis Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated wit... BeFree 25454804 Detail
0.007 stomach carcinoma Our data suggest that CD14 promoter-159TT and T carrier were associated with low... BeFree 19847953 Detail
0.004 familial Mediterranean fever TLR polymorphisms in FMF: association of TLR-2 (Arg753Gln) and TLR-4 (Asp299Gly,... BeFree 20714796 Detail
0.010 Septicemia Lack of association between TLR4 Asp299Gly and Thr399Ile polymorphisms and sepsi... BeFree 22537674 Detail
0.003 Cirrhosis The present study aimed to investigate the association between TLR4 mutations (A... BeFree 18666712 Detail
0.009 Malignant neoplasm of stomach Based on our meta-analysis, the TLR signalling pathway is involved in gastric ca... BeFree 23565226 Detail
0.031 periodontitis No differences were found in the prevalence of the TLR4 Asp299Gly genotype in me... BeFree 17309585 Detail
0.012 Cardiovascular Diseases We evaluated the TLR4 D299G polymorphism among 695 individuals with incident myo... BeFree 15576653 Detail
0.009 Giant Cell Arteritis This meta-analysis demonstrates that the TLR4 Asp299Gly polymorphism may confer ... BeFree 23065292 Detail
0.183 Crohn Disease Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Croh... BeFree 18213697 Detail
0.003 Chlamydia Infections The Arg753Gln TLR2 and Asp299Gly TLR4 polymorphisms were not related to chlamydi... BeFree 15175649 Detail
0.158 atherosclerosis Lack of association between TLR4 Asp299Gly polymorphism and atherosclerosis: evi... BeFree 22857799 Detail
<0.001 Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Genotyping for CD14 (-159C/T) and TLR4 (Asp 299Gly and Thr 399Ile) was performed... BeFree 17086894 Detail
0.007 stomach carcinoma Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in gastric cancer of ... BeFree 18826495 Detail
<0.001 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) Our findings suggest that Toll-like receptor 2 gene Arg753Gln and Toll-like rece... BeFree 22429552 Detail
0.560 Crohn Disease Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Croh... BeFree 18213697 Detail
0.005 Mycoses The patient was in complete hematologic remission and molecular analyses did not... BeFree 17885950 Detail
<0.001 vitiligo Our findings suggest that Toll-like receptor 2 gene Arg753Gln and Toll-like rece... BeFree 22429552 Detail
0.017 periodontitis The prevalence of TLR2 Arp677Trp polymorphism seemed to be rather high, while th... BeFree 18618036 Detail
0.001 Severe Sepsis Two common SNPs of the TLR2 and TLR4 genes--Arg753Gln and Asp299Gly--were associ... BeFree 24366499 Detail
0.009 Malignant neoplasm of stomach We investigated the effects of common polymorphisms of TLR4 Asp299Gly, Thr399Ile... BeFree 19326213 Detail
<0.001 Sepsis Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated wit... BeFree 25454804 Detail
0.010 Coronary Arteriosclerosis TLR4 gene polymorphism (Asp299Gly) attenuates innate immune responsiveness, redu... BeFree 19273219 Detail
0.004 Ischemic stroke Toll-like receptor 4 gene C119A but not Asp299Gly polymorphism is associated wit... BeFree 15910856 Detail
0.010 ankylosing spondylitis Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms do not contribute to ... BeFree 16567359 Detail
0.003 epilepsy A total of 140 patients with NCC (82 symptomatic [ie, with active epilepsy] and ... BeFree 20807077 Detail
0.001 Malignant tumor of cervix Impact of Toll-like receptors [TLR] 2 (-196 to -174 del) and TLR 4 (Asp299Gly, T... BeFree 19541348 Detail
0.244 Sepsis Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were i... BeFree 25427560 Detail
0.009 Malignant neoplasm of stomach Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in gastric cancer of ... BeFree 18826495 Detail
0.004 cystic fibrosis Modifier effect of the Toll-like receptor 4 D299G polymorphism in children with ... BeFree 16830219 Detail
0.006 Mucosa-Associated Lymphoid Tissue Lymphoma Furthermore, the TLR4 Asp299Gly variant was positively associated with the risk ... BeFree 16971956 Detail
0.005 Mycoses [For fungi, a significant association was observed between the presence of the c... GAD 19539691 Detail
0.002 Malignant neoplasm of stomach Based on our meta-analysis, the TLR signalling pathway is involved in gastric ca... BeFree 23565226 Detail
0.007 stomach carcinoma TLR4/D299G/T399I polymorphisms were more frequent in duodenal ulcer and showed a... BeFree 18755634 Detail
0.002 Cerebrovascular accident These data possibly implicate TLR4 as an important genetic factor for stroke in ... BeFree 15910856 Detail
<0.001 Septicemia Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated wit... BeFree 25454804 Detail
<0.001 Coinfection After a multivariate analysis, HCV co-infection (OR= 3.8; 95% CI [2.2-6.5]), bas... BeFree 20226000 Detail
0.006 Mucosa-Associated Lymphoid Tissue Lymphoma Genotyping for CD14 (-159C/T) and TLR4 (Asp 299Gly and Thr 399Ile) was performed... BeFree 17086894 Detail
0.003 Lupus Erythematosus, Systemic Association of TLR4 (D299G, T399I), TLR9 -1486T&gt;C, TIRAP S180L and TNF-α prom... BeFree 25182168 Detail
0.012 Inflammatory Bowel Diseases The c.1-260C&gt;T promoter variant of CD14 but not the c.896A&gt;G (p.D299G) var... BeFree 18174680 Detail
0.021 myocardial infarction We demonstrated that TLR4 ASP299GLY polymorphism shows a significantly lower fre... BeFree 16803999 Detail
0.027 rheumatoid arthritis Lack of association between TLR4 rs4986790 polymorphism and risk of cardiovascul... BeFree 22360682 Detail
0.002 Malignant neoplasm of stomach The association between Toll-like receptor 2 (TLR2) -196 to -174del polymorphism... BeFree 24007538 Detail
0.012 Tuberculosis, Pulmonary Human Toll-like receptor 4 polymorphisms TLR4 Asp299Gly and Thr399Ile influence ... BeFree 20403143 Detail
0.005 Mycoses For fungi, a significant association was observed between the presence of the co... BeFree 19539691 Detail
0.012 Tuberculosis, Pulmonary No association between TLR4 Asp299Gly and pulmonary TB was found. BeFree 18008256 Detail
0.005 hepatitis B Toll-like receptor 4 rs4986790 (p.Asp299Gly) was associated with HBsAg seroclear... BeFree 22740716 Detail
0.002 liver cirrhosis The present study aimed to investigate the association between TLR4 mutations (A... BeFree 18666712 Detail
0.002 Cerebrovascular accident This study was aimed to detect two commonly reported Asp299Gly and Thr399Ile pol... BeFree 20504212 Detail
<0.001 Wheezing No association was found between TLR4/Asp299Gly and lung function or wheeze. BeFree 15591473 Detail
0.006 endometriosis Molecular pathogenesis of endometriosis; Toll-like receptor-4 A896G (D299G) poly... BeFree 21214494 Detail
0.158 atherosclerosis The G allele of the Toll-like receptor 4 (TLR-4) gene Asp299Gly polymorphism has... BeFree 17996871 Detail
0.013 arteriosclerosis For this purpose we investigated the prevalence and any possible associations of... BeFree 20169003 Detail
0.034 asthma Wherease some previous studies indicated TLRs and their polymorphisms might have... BeFree 25530138 Detail
<0.001 Gram-negative bacteremia Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) hav... BeFree 18034244 Detail
0.058 asthma Association between the TLR4 +896A&gt;G (Asp299Gly) polymorphism and asthma: a s... BeFree 23574398 Detail
0.158 atherosclerosis In summary, results in our study do not support the hypothesis that the rs498679... BeFree 22360682 Detail
<0.001 Necrosis of pancreas Toll-like receptor 4 Asp299Gly polymorphism is associated with the infection of ... BeFree 17414051 Detail
0.136 age related macular degeneration Although an intronic SNP in TLR4 was associated marginally with AMD (P = 0.03), ... BeFree 18385087 Detail
0.244 Sepsis In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and T... BeFree 21968286 Detail
0.003 Malignant neoplasm of breast The -174 to -196del of TLR2 gene and Asp299Gly of TLR4 gene polymorphisms may co... BeFree 22560646 Detail
<0.001 Atherosclerosis of aorta The Asp299Gly Toll-like receptor 4 polymorphism in advanced aortic atheroscleros... BeFree 17587646 Detail
<0.001 Pancreas infection Compared with healthy volunteers (5.6%), TLR4 896G allele frequencies was signif... BeFree 17414051 Detail
<0.001 Pneumonitis Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were i... BeFree 25427560 Detail
0.004 cervix carcinoma Impact of Toll-like receptors [TLR] 2 (-196 to -174 del) and TLR 4 (Asp299Gly, T... BeFree 19541348 Detail
Annotation

Annotations

DescrptionSourceLinks
NM_138554.5(TLR4):c.896A>G (p.Asp299Gly) AND TLR4 POLYMORPHISM ClinVar Detail
NM_138554.5(TLR4):c.896A>G (p.Asp299Gly) AND Pericementitis ClinVar Detail
NM_138554.5(TLR4):c.896A>G (p.Asp299Gly) AND Susceptibility to severe coronavirus disease (COVID-19) ClinVar Detail
NM_138554.5(TLR4):c.896A>G (p.Asp299Gly) AND COPD, severe early onset ClinVar Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to ex... DisGeNET Detail
Polymorphisms of the toll-like receptor 2 (TLR2) gene (Arg677Trp, Arg753Gln) and the TLR4 gene (Asp2... DisGeNET Detail
In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gly or Thr399Ile and T... DisGeNET Detail
In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gly or Thr399Ile and T... DisGeNET Detail
In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gly or Thr399Ile and T... DisGeNET Detail
In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gly or Thr399Ile and T... DisGeNET Detail
Nonconservative single nucleotide polymorphisms in the coding regions of TLR-2 (Arg677Trp and Arg753... DisGeNET Detail
In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gly or Thr399Ile and T... DisGeNET Detail
Nonconservative single nucleotide polymorphisms in the coding regions of TLR-2 (Arg677Trp and Arg753... DisGeNET Detail
Relationship between toll-like receptor 2 Arg677Trp and Arg753Gln and toll-like receptor 4 Asp299Gly... DisGeNET Detail
Nonconservative single nucleotide polymorphisms in the coding regions of TLR-2 (Arg677Trp and Arg753... DisGeNET Detail
Nonconservative single nucleotide polymorphisms in the coding regions of TLR-2 (Arg677Trp and Arg753... DisGeNET Detail
In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gly or Thr399Ile and T... DisGeNET Detail
Polymorphisms of the toll-like receptor 2 (TLR2) gene (Arg677Trp, Arg753Gln) and the TLR4 gene (Asp2... DisGeNET Detail
In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gly or Thr399Ile and T... DisGeNET Detail
Relationship between toll-like receptor 2 Arg677Trp and Arg753Gln and toll-like receptor 4 Asp299Gly... DisGeNET Detail
In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gly or Thr399Ile and T... DisGeNET Detail
In our study, TNF-alpha, soluble TNF receptor 1 (sTNFR1), and soluble TNF receptor 2 (sTNFR2) levels... DisGeNET Detail
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G... DisGeNET Detail
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G... DisGeNET Detail
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G... DisGeNET Detail
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G... DisGeNET Detail
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G... DisGeNET Detail
Interestingly, the rs4986790 TLR4 polymorphism confers a higher susceptibility for sporadic TAA (OR ... DisGeNET Detail
Interestingly, the rs4986790 TLR4 polymorphism confers a higher susceptibility for sporadic TAA (OR ... DisGeNET Detail
Interestingly, the rs4986790 TLR4 polymorphism confers a higher susceptibility for sporadic TAA (OR ... DisGeNET Detail
Single-nucleotide polymorphisms in three innate immune genes were associated with development of a C... DisGeNET Detail
We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability i... DisGeNET Detail
We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability i... DisGeNET Detail
We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability i... DisGeNET Detail
We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability i... DisGeNET Detail
We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability i... DisGeNET Detail
Two SNPs were associated with BV as diagnosed by the Nugent score and the combined criteria: a minor... DisGeNET Detail
We investigated the allelic frequencies of TLR4 (D299G and T399I) and NOD2/CARD15 (R702W, G908R, and... DisGeNET Detail
We investigated the allelic frequencies of TLR4 (D299G and T399I) and NOD2/CARD15 (R702W, G908R, and... DisGeNET Detail
To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative c... DisGeNET Detail
To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative c... DisGeNET Detail
To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative c... DisGeNET Detail
The TLR4/Asp299Gly and CD14/C-260T polymorphisms and plasma sCD14 concentrations do not appear as si... DisGeNET Detail
Even with previously verified samples sets and adequate study powers, the results did not confirm th... DisGeNET Detail
Even with previously verified samples sets and adequate study powers, the results did not confirm th... DisGeNET Detail
The Mal S180L and TLR4 G299D polymorphisms do not contribute to RA susceptibility or severity either... DisGeNET Detail
The tlr-4 (D299G and T399I), tlr-9 (T-1486C and T-1237C) and tirap (S180L) genes were assessed in 64... DisGeNET Detail
The tlr-4 (D299G and T399I), tlr-9 (T-1486C and T-1237C) and tirap (S180L) genes were assessed in 64... DisGeNET Detail
Decreased LPS-induced IL-12(p70) and IL-10 responses were associated with the TLR4 (Asp299Gly) polym... DisGeNET Detail
Lack of genetic association of the Toll-like receptor 4 (TLR4) Asp299Gly and Thr399Ile polymorphisms... DisGeNET Detail
Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -251 polymorphisms in ... DisGeNET Detail
The Arg753Gln TLR2 and Asp299Gly TLR4 polymorphisms were not related to chlamydial infection. DisGeNET Detail
The findings of this study do not support the hypothesis that the TLR4 Asp299Gly polymorphism influe... DisGeNET Detail
TLR-4 Asp299Gly G allele substitution may be modified pattern of immune response in the gastric muco... DisGeNET Detail
Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be a... DisGeNET Detail
The purpose of this study was to investigate the role of a common Asp299Gly polymorphism of the TLR-... DisGeNET Detail
Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 pol... DisGeNET Detail
Toll-like receptor 4 gene Asp299Gly and Thr399Ile polymorphisms in type 2 diabetes mellitus: a meta-... DisGeNET Detail
A total of 3000 individuals from the prospective community-based Carotid Atherosclerosis Progression... DisGeNET Detail
The c.1-260C&gt;T promoter variant of CD14 but not the c.896A&gt;G (p.D299G) variant of toll-like re... DisGeNET Detail
We studied the TLR4 gene Asp299Gly polymorphism in relation to susceptibility to myocardial infarcti... DisGeNET Detail
IL-10 production was higher in C. albicans-stimulated PBMC from volunteers bearing the TLR4 Asp299Gl... DisGeNET Detail
We screened 197 individuals suffering from generalized periodontitis for the presence of Asp299Gly a... DisGeNET Detail
However, the C/C genotype for the TLR3 (c.1377 C&gt;T) polymorphism and the Asp/Asp genotype and the... DisGeNET Detail
TLR polymorphisms in FMF: association of TLR-2 (Arg753Gln) and TLR-4 (Asp299Gly, Thre399Ile) polymor... DisGeNET Detail
We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(... DisGeNET Detail
Toll-like receptor 4 D299G polymorphism could influence not only the predisposition to bacterial inf... DisGeNET Detail
Determination of the TLR4 Asp299Gly/Thr399Ile haplotype is of no clinical benefit in predicting the ... DisGeNET Detail
The Toll-like receptor 4 D299G and T399I polymorphisms are associated with Crohn's disease and ulcer... DisGeNET Detail
In conclusion, the TLR4 Asp299Gly variant seems to confer protection against hemorrhagic cystitis. DisGeNET Detail
However, the C/C genotype for the TLR3 (c.1377 C&gt;T) polymorphism and the Asp/Asp genotype and the... DisGeNET Detail
We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(... DisGeNET Detail
TLR4/D299G/T399I polymorphisms were more frequent in duodenal ulcer and showed a trend in gastric ca... DisGeNET Detail
Positive link between variant Toll-like receptor 4 (Asp299Gly and Thr399Ile) and colorectal cancer p... DisGeNET Detail
TLR4 A896G polymorphism (rs4986790) is a functional polymorphism resulting in hypo-responsiveness of... DisGeNET Detail
Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 pol... DisGeNET Detail
Recently, an association between TLR-4 polymorphism Asp299Gly, leading to a change in the extracellu... DisGeNET Detail
Polymorphisms in TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes are associated with bacteria... DisGeNET Detail
Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammat... DisGeNET Detail
Our findings suggest that Toll-like receptor 2 gene Arg753Gln and Toll-like receptor 4 Asp299Gly gen... DisGeNET Detail
Two polymorphisms of the TLR4 gene (Asp299Gly and Thr399Ile) were determined in 655 men with angiogr... DisGeNET Detail
In summary, results in our study do not support the hypothesis that the rs4986790 (+896A&gt;G, Asp29... DisGeNET Detail
Common SNPs of the TLR2 (Arg753Gln) and co-segregating TLR4 (Asp299Gly and Thr399Ile) genes were scr... DisGeNET Detail
Genotyping for the TLR4 single-nucleotide polymorphisms (SNPs) Asp299Gly, Thr399Ile and the CD14 SNP... DisGeNET Detail
Toll-like receptor 4 gene C119A but not Asp299Gly polymorphism is associated with ischemic stroke am... DisGeNET Detail
Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and typhoid susceptibility in Asian Malay... DisGeNET Detail
Two common SNPs of the TLR2 and TLR4 genes--Arg753Gln and Asp299Gly--were associated with a shorter ... DisGeNET Detail
Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be a... DisGeNET Detail
No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C260T polymorphisms in... DisGeNET Detail
Two single nucleotide polymorphisms (SNPs) encoding Asp299Gly and Thr399Ile substitutions in the TLR... DisGeNET Detail
Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -251 polymorphisms in ... DisGeNET Detail
The G allele of the Toll-like receptor 4 (TLR-4) gene Asp299Gly polymorphism has been previously ass... DisGeNET Detail
Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in Ge... DisGeNET Detail
The TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped and tested for case-control frequency ... DisGeNET Detail
We initiated a pilot study in preterm children to determine the prevalence of single nucleotide poly... DisGeNET Detail
In conclusion, we report an association of microsatelite GT polymorphisms of TLR2 gene and Asp299Gly... DisGeNET Detail
We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory respons... DisGeNET Detail
Our data suggest that CD14 promoter-159TT and T carrier were associated with lower risk of developin... DisGeNET Detail
Two specific polymorphisms of toll-like receptor 4 (TLR4; Asp299Gly and Thr399Ile) have recently bee... DisGeNET Detail
Wherease some previous studies indicated TLRs and their polymorphisms might have some role in asthma... DisGeNET Detail
TLR4 gene polymorphism (Asp299Gly) attenuates innate immune responsiveness, reduces the risk for cor... DisGeNET Detail
Our objective was to determine the frequency of TNF-alpha -238, -308 G/A promoter and TLR-4 299 D/G ... DisGeNET Detail
We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory respons... DisGeNET Detail
This study was aimed to detect two commonly reported Asp299Gly and Thr399Ile polymorphisms in TLR4 g... DisGeNET Detail
Lack of association between TLR4 Asp299Gly polymorphism and atherosclerosis: evidence from meta-anal... DisGeNET Detail
The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in ... DisGeNET Detail
The findings of this study do not support the hypothesis that the TLR4 Asp299Gly polymorphism influe... DisGeNET Detail
Lack of association between TLR4 rs4986790 polymorphism and risk of cardiovascular disease in patien... DisGeNET Detail
Based on our meta-analysis, the TLR signalling pathway is involved in gastric carcinogenesis, TLR4 A... DisGeNET Detail
The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR4-mediated cytokine ... DisGeNET Detail
Genotyping for the TLR4 single-nucleotide polymorphisms (SNPs) Asp299Gly, Thr399Ile and the CD14 SNP... DisGeNET Detail
We found a greater risk of developing active tuberculosis as well as a reduction in CD4 T-cell count... DisGeNET Detail
Association of Toll-like receptor-4 (Asp299Gly and Thr399Ileu) gene polymorphisms with gastritis and... DisGeNET Detail
1400 participants (mean age: 63 years, 31% female) in the Southampton Atherosclerosis Study were gen... DisGeNET Detail
No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C260T polymorphisms in... DisGeNET Detail
Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammat... DisGeNET Detail
Toll-like receptor 4 Asp299Gly polymorphism in respiratory syncytial virus epidemics. DisGeNET Detail
Toll-like receptor 4 gene Asp299Gly polymorphism in myocardial infarction: a meta-analysis of 15,148... DisGeNET Detail
The toll-like receptor 4 Asp299Gly variant and tuberculosis susceptibility in HIV-infected patients ... DisGeNET Detail
The toll-like receptor 4 Asp299Gly variant and tuberculosis susceptibility in HIV-infected patients ... DisGeNET Detail
No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C260T polymorphisms in... DisGeNET Detail
The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in ... DisGeNET Detail
We describe an independent association between TLR4 Asp299Gly SNP and active TB in Caucasian Mediter... DisGeNET Detail
Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammat... DisGeNET Detail
Our overall analyses indicated that TLR4 Asp299Gly polymorphism might contribute to RA pathogenesis. DisGeNET Detail
Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammat... DisGeNET Detail
This implies that the Asp299Gly TLR4-allele might have a protective role in carotid atherosclerosis,... DisGeNET Detail
The aim of this study was to investigate the possible role of polymorphisms of TLR4, Asp299Gly and T... DisGeNET Detail
The TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped and tested for case-control frequency ... DisGeNET Detail
TLR polymorphisms in FMF: association of TLR-2 (Arg753Gln) and TLR-4 (Asp299Gly, Thre399Ile) polymor... DisGeNET Detail
Decreased LPS-induced IL-12(p70) and IL-10 responses were associated with the TLR4 (Asp299Gly) polym... DisGeNET Detail
The Asp299Gly polymorphism in TLR4 was associated with increased insulin, homeostasis model assessme... DisGeNET Detail
In contrast, the heterozygous Toll-like receptor 4 (TLR4)-deficiency genotype D299G/T399I occurred m... DisGeNET Detail
The TLR4 ASP299GLY polymorphism is a risk factor for active tuberculosis in Caucasian HIV-infected p... DisGeNET Detail
The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399I... DisGeNET Detail
Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 pol... DisGeNET Detail
Polymorphisms in TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes are associated with bacteria... DisGeNET Detail
We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(... DisGeNET Detail
Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 pol... DisGeNET Detail
The purpose of this study was to investigate the role of a common Asp299Gly polymorphism of the TLR-... DisGeNET Detail
The Toll-like receptor 4 D299G and T399I polymorphisms are associated with Crohn's disease and ulcer... DisGeNET Detail
The findings of this study do not support the hypothesis that the TLR4 Asp299Gly polymorphism influe... DisGeNET Detail
We have reported on a novel association of the TLR4 Asp299Gly polymorphism with both CD and UC. DisGeNET Detail
Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be a... DisGeNET Detail
The association between Toll-like receptor 2 (TLR2) -196 to -174del polymorphism and Toll-like recep... DisGeNET Detail
Common SNPs of the TLR2 (Arg753Gln) and co-segregating TLR4 (Asp299Gly and Thr399Ile) genes were scr... DisGeNET Detail
At stepwise logistic regression analysis, the carriage of TLR-4 rs4986790 A/A genotype was found to ... DisGeNET Detail
We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(... DisGeNET Detail
The effect of TLR4 D299G on long-term graft survival was analyzed based on hepatitis C virus (HCV) s... DisGeNET Detail
We studied the TLR4 gene Asp299Gly polymorphism in relation to susceptibility to myocardial infarcti... DisGeNET Detail
In support of this idea, we have recently demonstrated that lung recipients heterozygous for either ... DisGeNET Detail
The Asp299Gly TLR4 polymorphism, which attenuates receptor signaling and diminishes the inflammatory... DisGeNET Detail
Polymorphisms in TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes are associated with bacteria... DisGeNET Detail
A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pul... DisGeNET Detail
Based on our meta-analysis, the TLR signalling pathway is involved in gastric carcinogenesis, TLR4 A... DisGeNET Detail
The association of the D299G polymorphism of the TLR-4 gene with the progression of coronary and car... DisGeNET Detail
The aim of this study was to investigate the association of TLR2 R753Q, TLR4 D299G, and T399I polymo... DisGeNET Detail
A polymorphism of the TLR4 gene, Asp299Gly, is associated with an increased risk for coronary heart ... DisGeNET Detail
Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 pol... DisGeNET Detail
Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk fact... DisGeNET Detail
TLR-4 Asp299Gly G allele substitution may be modified pattern of immune response in the gastric muco... DisGeNET Detail
The presence of TLR-4 Asp299Gly and TLR-4 Thr399Ile polymorphisms is related to UC pancolitis, invol... DisGeNET Detail
TLR4/D299G/T399I polymorphisms were more frequent in duodenal ulcer and showed a trend in gastric ca... DisGeNET Detail
Two specific polymorphisms of toll-like receptor 4 (TLR4; Asp299Gly and Thr399Ile) have recently bee... DisGeNET Detail
In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European... DisGeNET Detail
Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of atherosclerosis in pat... DisGeNET Detail
We investigated the effects of common polymorphisms of TLR4 Asp299Gly, Thr399Ile, and CD14 promoter-... DisGeNET Detail
Genotyping for the TLR4 single-nucleotide polymorphisms (SNPs) Asp299Gly, Thr399Ile and the CD14 SNP... DisGeNET Detail
We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(... DisGeNET Detail
Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -251 polymorphisms in ... DisGeNET Detail
Recently, the common Asp299Gly polymorphism of the Toll-like receptor 4 (TLR-4) was found to be asso... DisGeNET Detail
Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabe... DisGeNET Detail
Association of TLR4 (D299G, T399I), TLR9 -1486T&gt;C, TIRAP S180L and TNF-α promoter (-1031, -863, -... DisGeNET Detail
The Toll-like receptor 4 (Asp299Gly) polymorphism is a risk factor for Gram-negative and haematogeno... DisGeNET Detail
Genotyping for the TLR4 single-nucleotide polymorphisms (SNPs) Asp299Gly, Thr399Ile and the CD14 SNP... DisGeNET Detail
Genotyping for the TLR4 single-nucleotide polymorphisms (SNPs) Asp299Gly, Thr399Ile and the CD14 SNP... DisGeNET Detail
An improved overall survival (Hazard ratio HR 0.53, 95% CI 0.32-0.88) and survival following metasta... DisGeNET Detail
Therefore, the aim of this study was to investigate the association between the TLR4 Asp299Gly and T... DisGeNET Detail
Our data suggest that CD14 promoter-159TT and T carrier were associated with lower risk of developin... DisGeNET Detail
[Candidate single nucleotide polymorphisms (SNPs) within bacterial recognition (TLR4 +896, CD14 -159... DisGeNET Detail
We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory respons... DisGeNET Detail
Our data indicate that Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with reduce... DisGeNET Detail
In this two-center, retrospective German and Hungarian cohort study, patients with Crohn's disease (... DisGeNET Detail
TLR4 D299G polymorphism modulates cytokine expression in ulcerative colitis. DisGeNET Detail
We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(... DisGeNET Detail
TLR4(D299G/T399I) associates with increased total body fat, visceral fat, liver fat and decreased in... DisGeNET Detail
Our findings suggest that Toll-like receptor 2 gene Arg753Gln and Toll-like receptor 4 Asp299Gly gen... DisGeNET Detail
We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(... DisGeNET Detail
The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399I... DisGeNET Detail
The presence of TLR-4 Asp299Gly and TLR-4 Thr399Ile polymorphisms is related to UC pancolitis, invol... DisGeNET Detail
Lack of association between Toll-like receptor 4 gene Asp299Gly and Thr399Ile polymorphisms and tube... DisGeNET Detail
However, the C/C genotype for the TLR3 (c.1377 C&gt;T) polymorphism and the Asp/Asp genotype and the... DisGeNET Detail
Impact of the Asp299Gly polymorphism in the toll-like receptor 4 (tlr-4) gene on disease course of m... DisGeNET Detail
Overall, no heterozygous or homozygous single nucleotide polymorphism mutations were found in patien... DisGeNET Detail
We screened 197 individuals suffering from generalized periodontitis for the presence of Asp299Gly a... DisGeNET Detail
Toll-like receptor (TLR) polymorphisms, and especially TLR-4 Asp299Gly and TLR-4 Thr399Ile, have bee... DisGeNET Detail
We studied the TLR4 gene Asp299Gly polymorphism in relation to susceptibility to myocardial infarcti... DisGeNET Detail
TLR4 D299G and T399I SNPs that are associated with protection from hepatic fibrosis reduce TLR4-medi... DisGeNET Detail
The study included nine patients with cirrhosis and TLR4 D299G and/or T399I polymorphisms, and 10 wi... DisGeNET Detail
To conclude, TLR4 D299G increases the risk for SLE, while TNF-α CCC haplotype reduces the risk for S... DisGeNET Detail
Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -251 polymorphisms in ... DisGeNET Detail
Positive link between variant Toll-like receptor 4 (Asp299Gly and Thr399Ile) and colorectal cancer p... DisGeNET Detail
The c.1-260C&gt;T promoter variant of CD14 but not the c.896A&gt;G (p.D299G) variant of toll-like re... DisGeNET Detail
A total of 3000 individuals from the prospective community-based Carotid Atherosclerosis Progression... DisGeNET Detail
Caco-2 cells that expressed TLR4-D299G had significant increases in expression levels of genes and p... DisGeNET Detail
However, we detected that A allele carriers of the TLR4 Asp299Gly polymorphism might have an increas... DisGeNET Detail
We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(... DisGeNET Detail
Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of atherosclerosis in pat... DisGeNET Detail
Therefore, the aim of this study was to investigate the association between the TLR4 Asp299Gly and T... DisGeNET Detail
Toll-like receptor 4 D299G polymorphism in metabolic disorders: a meta-analysis. DisGeNET Detail
Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk fact... DisGeNET Detail
Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 pol... DisGeNET Detail
A Toll-like receptor-4 (TLR-4) Asp299Gly and Thr399Ileu substitution reduces responsiveness to Helic... DisGeNET Detail
We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory respons... DisGeNET Detail
Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabe... DisGeNET Detail
In conclusion, we report an association of microsatelite GT polymorphisms of TLR2 gene and Asp299Gly... DisGeNET Detail
Toll like receptor 4 D299G associates with disease progression in Caucasian patients with chronic HB... DisGeNET Detail
A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pul... DisGeNET Detail
The -174 to -196del of TLR2 gene and Asp299Gly of TLR4 gene polymorphisms may confer an increased su... DisGeNET Detail
Expression of STAT3 messenger RNA was higher among colonic adenocarcinomas with TLR4-D299G than thos... DisGeNET Detail
Toll-like receptor 4 Asp299Gly polymorphism is associated with an increased risk of pancreatic necro... DisGeNET Detail
For this purpose we investigated the prevalence and any possible associations of common TLR polymorp... DisGeNET Detail
Our data suggest that CD14 promoter-159TT and T carrier were associated with lower risk of developin... DisGeNET Detail
To examine whether TLR4 Asp299Gly, CD14-260C/T, TNF-1031T/C, TNF-863C/A, TNF-857C/T, TACE-172C/T, an... DisGeNET Detail
The aim of this study was to investigate the possible role of polymorphisms of TLR4, Asp299Gly and T... DisGeNET Detail
1400 participants (mean age: 63 years, 31% female) in the Southampton Atherosclerosis Study were gen... DisGeNET Detail
In this two-center, retrospective German and Hungarian cohort study, patients with Crohn's disease (... DisGeNET Detail
Lack of association of TLR4 gene Asp299Gly and Thr399Ile polymorphisms with rheumatoid arthritis in ... DisGeNET Detail
Association of TLR4 (D299G, T399I), TLR9 -1486T&gt;C, TIRAP S180L and TNF-α promoter (-1031, -863, -... DisGeNET Detail
TLR4(D299G/T399I) associates with increased total body fat, visceral fat, liver fat and decreased in... DisGeNET Detail
By use of a polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) anal... DisGeNET Detail
We evaluated the TLR4 D299G polymorphism among 695 individuals with incident myocardial infarction (... DisGeNET Detail
TLR4 gene polymorphism (Asp299Gly) attenuates innate immune responsiveness, reduces the risk for cor... DisGeNET Detail
Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammat... DisGeNET Detail
Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of IC... DisGeNET Detail
Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of atherosclerosis in pat... DisGeNET Detail
To examine whether TLR4 Asp299Gly, CD14-260C/T, TNF-1031T/C, TNF-863C/A, TNF-857C/T, TACE-172C/T, an... DisGeNET Detail
However, the C/C genotype for the TLR3 (c.1377 C&gt;T) polymorphism and the Asp/Asp genotype and the... DisGeNET Detail
Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamo... DisGeNET Detail
We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory respons... DisGeNET Detail
This study genotyped 2 TLR4 mutations, Asp299Gly and Thr399Ile, and 2 single-nucleotide polymorphism... DisGeNET Detail
Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degenera... DisGeNET Detail
Our data suggest that CD14 promoter-159TT and T carrier were associated with lower risk of developin... DisGeNET Detail
Our data suggest that CD14 promoter-159TT and T carrier were associated with lower risk of developin... DisGeNET Detail
A non-synonymous variant in the extracellular domain of TLR4 (G299D) has been shown to interrupt TLR... DisGeNET Detail
None polymorphisms of Asp299Gly and Thr399Ile were detected in all GA cases and controls, which indi... DisGeNET Detail
The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399I... DisGeNET Detail
In this two-center, retrospective German and Hungarian cohort study, patients with Crohn's disease (... DisGeNET Detail
Association of Toll-like receptor-4 (Asp299Gly and Thr399Ileu) gene polymorphisms with gastritis and... DisGeNET Detail
The Asp299Gly TLR4 polymorphism, which attenuates receptor signaling and diminishes the inflammatory... DisGeNET Detail
Lack of association between TLR4 Asp299Gly and Thr399Ile polymorphisms and sepsis susceptibility: a ... DisGeNET Detail
The Asp299Gly polymorphism in TLR4 was associated with increased insulin, homeostasis model assessme... DisGeNET Detail
Expression of STAT3 messenger RNA was higher among colonic adenocarcinomas with TLR4-D299G than thos... DisGeNET Detail
Association of TLR4 Asp299Gly and Thr399Ile polymorphisms with Guillain-Barré syndrome in Northern I... DisGeNET Detail
NA DisGeNET Detail
The results of this meta-analysis indicate that the TLR4 Asp299Gly and Thr399Ile polymorphisms are r... DisGeNET Detail
Recently, the common Asp299Gly polymorphism of the Toll-like receptor 4 (TLR-4) was found to be asso... DisGeNET Detail
These results, which must be confirmed by a prospective longitudinal study, provide evidence of an a... DisGeNET Detail
Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammat... DisGeNET Detail
Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms do not contribute to disease susceptibili... DisGeNET Detail
We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory respons... DisGeNET Detail
Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal c... DisGeNET Detail
Impact of Toll-like receptors [TLR] 2 (-196 to -174 del) and TLR 4 (Asp299Gly, Thr399Ile) in cervica... DisGeNET Detail
The results of this meta-analysis indicate that the TLR4 Asp299Gly and Thr399Ile polymorphisms are r... DisGeNET Detail
Decreased LPS-induced IL-12(p70) and IL-10 responses were associated with the TLR4 (Asp299Gly) polym... DisGeNET Detail
The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399I... DisGeNET Detail
The Asp299Gly polymorphism in the toll-like receptor 4 (TLR4) gene reduces responsiveness to lipopol... DisGeNET Detail
To investigate toll-like receptor 2 (TLR2) -196 to -174 del, and TLR4 (+896A/G rs4986790 and +1196C/... DisGeNET Detail
Human colon adenocarcinomas from patients with TLR4-D299G were more frequently of an advanced stage ... DisGeNET Detail
TLR4(D299G/T399I) associates with increased total body fat, visceral fat, liver fat and decreased in... DisGeNET Detail
Impact of Toll-like receptors [TLR] 2 (-196 to -174 del) and TLR 4 (Asp299Gly, Thr399Ile) in cervica... DisGeNET Detail
Role of TLR4 C&gt;1196T (Thr399Ile) and TLR4 A&gt;896G (Asp299Gly) polymorphisms in a North Indian p... DisGeNET Detail
Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal c... DisGeNET Detail
We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(... DisGeNET Detail
In a bivariate analysis several variables resulted significantly associated with active TB; intraven... DisGeNET Detail
Genotyping for the TLR4 single-nucleotide polymorphisms (SNPs) Asp299Gly, Thr399Ile and the CD14 SNP... DisGeNET Detail
May TLR4 Asp299Gly and IL17 His161Arg polymorphism be associated with progression of primary measles... DisGeNET Detail
Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal c... DisGeNET Detail
TLR4(D299G/T399I) associates with increased total body fat, visceral fat, liver fat and decreased in... DisGeNET Detail
We determined the frequency of polymorphisms in tumor necrosis factor-alpha[(TNF-alpha) G(-376)A, G(... DisGeNET Detail
To investigate toll-like receptor 2 (TLR2) -196 to -174 del, and TLR4 (+896A/G rs4986790 and +1196C/... DisGeNET Detail
Positive link between variant Toll-like receptor 4 (Asp299Gly and Thr399Ile) and colorectal cancer p... DisGeNET Detail
The prevalence of TLR2 Arp677Trp polymorphism seemed to be rather high, while that of TLR4 Asp299Gly... DisGeNET Detail
It is concluded that in West European Caucasians, the Asp299Gly TLR4 gene polymorphism is associated... DisGeNET Detail
The aim of this study was to investigate the possible role of polymorphisms of TLR4, Asp299Gly and T... DisGeNET Detail
The -174 to -196del of TLR2 gene and Asp299Gly of TLR4 gene polymorphisms may confer an increased su... DisGeNET Detail
Polymorphisms of the toll-like receptor (TLR) 2 (Arg677Trp, Arg753Gln) and TLR4 (Asp299Gly, Thr399Il... DisGeNET Detail
This meta-analysis shows lack of an association between the TLR4 Asp299Gly polymorphism and RA. DisGeNET Detail
The presence of the D299G and T399I polymorphisms of the TLR-4 gene does not play a major role on th... DisGeNET Detail
TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respi... DisGeNET Detail
The toll-like receptor 4 Asp299Gly variant: no influence on LPS responsiveness or susceptibility to ... DisGeNET Detail
In this study, we aimed to determine the relation of TLR-4 Asp299Gly and Thr399Ile polymorphisms and... DisGeNET Detail
The -174 to -196del of TLR2 gene and Asp299Gly of TLR4 gene polymorphisms may confer an increased su... DisGeNET Detail
Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of IC... DisGeNET Detail
Our data suggest that CD14 promoter-159TT and T carrier were associated with lower risk of developin... DisGeNET Detail
TLR polymorphisms in FMF: association of TLR-2 (Arg753Gln) and TLR-4 (Asp299Gly, Thre399Ile) polymor... DisGeNET Detail
Lack of association between TLR4 Asp299Gly and Thr399Ile polymorphisms and sepsis susceptibility: a ... DisGeNET Detail
The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399I... DisGeNET Detail
Based on our meta-analysis, the TLR signalling pathway is involved in gastric carcinogenesis, TLR4 A... DisGeNET Detail
No differences were found in the prevalence of the TLR4 Asp299Gly genotype in men with CP (18.9%) co... DisGeNET Detail
We evaluated the TLR4 D299G polymorphism among 695 individuals with incident myocardial infarction (... DisGeNET Detail
This meta-analysis demonstrates that the TLR4 Asp299Gly polymorphism may confer susceptibility to GC... DisGeNET Detail
Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Au... DisGeNET Detail
The Arg753Gln TLR2 and Asp299Gly TLR4 polymorphisms were not related to chlamydial infection. DisGeNET Detail
Lack of association between TLR4 Asp299Gly polymorphism and atherosclerosis: evidence from meta-anal... DisGeNET Detail
Genotyping for CD14 (-159C/T) and TLR4 (Asp 299Gly and Thr 399Ile) was performed in 70 patients with... DisGeNET Detail
Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in gastric cancer of intestinal and diffu... DisGeNET Detail
Our findings suggest that Toll-like receptor 2 gene Arg753Gln and Toll-like receptor 4 Asp299Gly gen... DisGeNET Detail
Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Au... DisGeNET Detail
The patient was in complete hematologic remission and molecular analyses did not display the presenc... DisGeNET Detail
Our findings suggest that Toll-like receptor 2 gene Arg753Gln and Toll-like receptor 4 Asp299Gly gen... DisGeNET Detail
The prevalence of TLR2 Arp677Trp polymorphism seemed to be rather high, while that of TLR4 Asp299Gly... DisGeNET Detail
Two common SNPs of the TLR2 and TLR4 genes--Arg753Gln and Asp299Gly--were associated with a shorter ... DisGeNET Detail
We investigated the effects of common polymorphisms of TLR4 Asp299Gly, Thr399Ile, and CD14 promoter-... DisGeNET Detail
Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of IC... DisGeNET Detail
TLR4 gene polymorphism (Asp299Gly) attenuates innate immune responsiveness, reduces the risk for cor... DisGeNET Detail
Toll-like receptor 4 gene C119A but not Asp299Gly polymorphism is associated with ischemic stroke am... DisGeNET Detail
Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms do not contribute to disease susceptibili... DisGeNET Detail
A total of 140 patients with NCC (82 symptomatic [ie, with active epilepsy] and 58 asymptomatic) and... DisGeNET Detail
Impact of Toll-like receptors [TLR] 2 (-196 to -174 del) and TLR 4 (Asp299Gly, Thr399Ile) in cervica... DisGeNET Detail
Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk fact... DisGeNET Detail
Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in gastric cancer of intestinal and diffu... DisGeNET Detail
Modifier effect of the Toll-like receptor 4 D299G polymorphism in children with cystic fibrosis. DisGeNET Detail
Furthermore, the TLR4 Asp299Gly variant was positively associated with the risk of mucosa-associated... DisGeNET Detail
[For fungi, a significant association was observed between the presence of the cosegregating Asp299G... DisGeNET Detail
Based on our meta-analysis, the TLR signalling pathway is involved in gastric carcinogenesis, TLR4 A... DisGeNET Detail
TLR4/D299G/T399I polymorphisms were more frequent in duodenal ulcer and showed a trend in gastric ca... DisGeNET Detail
These data possibly implicate TLR4 as an important genetic factor for stroke in ethnic Chinese popul... DisGeNET Detail
Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of IC... DisGeNET Detail
After a multivariate analysis, HCV co-infection (OR= 3.8; 95% CI [2.2-6.5]), baseline CD4 count (OR=... DisGeNET Detail
Genotyping for CD14 (-159C/T) and TLR4 (Asp 299Gly and Thr 399Ile) was performed in 70 patients with... DisGeNET Detail
Association of TLR4 (D299G, T399I), TLR9 -1486T&gt;C, TIRAP S180L and TNF-α promoter (-1031, -863, -... DisGeNET Detail
The c.1-260C&gt;T promoter variant of CD14 but not the c.896A&gt;G (p.D299G) variant of toll-like re... DisGeNET Detail
We demonstrated that TLR4 ASP299GLY polymorphism shows a significantly lower frequency in patients a... DisGeNET Detail
Lack of association between TLR4 rs4986790 polymorphism and risk of cardiovascular disease in patien... DisGeNET Detail
The association between Toll-like receptor 2 (TLR2) -196 to -174del polymorphism and Toll-like recep... DisGeNET Detail
Human Toll-like receptor 4 polymorphisms TLR4 Asp299Gly and Thr399Ile influence susceptibility and s... DisGeNET Detail
For fungi, a significant association was observed between the presence of the cosegregating Asp299Gl... DisGeNET Detail
No association between TLR4 Asp299Gly and pulmonary TB was found. DisGeNET Detail
Toll-like receptor 4 rs4986790 (p.Asp299Gly) was associated with HBsAg seroclearance/seroconversion ... DisGeNET Detail
The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399I... DisGeNET Detail
This study was aimed to detect two commonly reported Asp299Gly and Thr399Ile polymorphisms in TLR4 g... DisGeNET Detail
No association was found between TLR4/Asp299Gly and lung function or wheeze. DisGeNET Detail
Molecular pathogenesis of endometriosis; Toll-like receptor-4 A896G (D299G) polymorphism: a novel ex... DisGeNET Detail
The G allele of the Toll-like receptor 4 (TLR-4) gene Asp299Gly polymorphism has been previously ass... DisGeNET Detail
For this purpose we investigated the prevalence and any possible associations of common TLR polymorp... DisGeNET Detail
Wherease some previous studies indicated TLRs and their polymorphisms might have some role in asthma... DisGeNET Detail
Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be a... DisGeNET Detail
Association between the TLR4 +896A&gt;G (Asp299Gly) polymorphism and asthma: a systematic review and... DisGeNET Detail
In summary, results in our study do not support the hypothesis that the rs4986790 (+896A&gt;G, Asp29... DisGeNET Detail
Toll-like receptor 4 Asp299Gly polymorphism is associated with the infection of pancreatic necrosis ... DisGeNET Detail
Although an intronic SNP in TLR4 was associated marginally with AMD (P = 0.03), it was not possible ... DisGeNET Detail
In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European... DisGeNET Detail
The -174 to -196del of TLR2 gene and Asp299Gly of TLR4 gene polymorphisms may confer an increased su... DisGeNET Detail
The Asp299Gly Toll-like receptor 4 polymorphism in advanced aortic atherosclerosis. DisGeNET Detail
Compared with healthy volunteers (5.6%), TLR4 896G allele frequencies was significantly higher in AP... DisGeNET Detail
Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk fact... DisGeNET Detail
Impact of Toll-like receptors [TLR] 2 (-196 to -174 del) and TLR 4 (Asp299Gly, Thr399Ile) in cervica... DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs4986790 dbSNP
Genome
hg19
Position
chr9:120,475,302-120,475,302
Variant Type
snv
Reference Allele
A
Alternative Allele
G
Filtering Status (HGVD)
PASS
# of samples (HGVD)
1210
Mean of sample read depth (HGVD)
220.83
Standard deviation of sample read depth (HGVD)
91.41
Number of reference allele (HGVD)
2415
Number of alternative allele (HGVD)
5
Allele Frequency (HGVD)
0.002066115702479339
Gene Symbol (HGVD)
TLR4
East Asian Chromosome Counts (ExAC)
8642
East Asian Allele Counts (ExAC)
3
East Asian Heterozygous Counts (ExAC)
3
East Asian Homozygous Counts (ExAC)
0
East Asian Allele Frequency (ExAC)
3.4714186530895625E-4
Chromosome Counts in All Race (ExAC)
121242
Allele Counts in All Race (ExAC)
7262
Heterozygous Counts in All Race (ExAC)
6704
Homozygous Counts in All Race (ExAC)
279
Allele Frequency in All Race (ExAC)
0.059896735454710415
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