Annotation Detail

Information
Associated Genes
TLR4
Associated Variants
CD14 c.-221-39T>C ( ENST00000498971.7, ENST00000512545.2, ENST00000519715.2 )
ENSG00000285082 c.140+4295A>G, TLR4 p.Asp299Gly (p.D299G) ( ENST00000355622.8, ENST00000394487.5, ENST00000472304.2 )
CD14 c.-221-39T>C ( ENST00000498971.7, ENST00000512545.2, ENST00000519715.2 )
ENSG00000285082 c.140+4295A>G, TLR4 p.Asp299Gly (p.D299G) ( ENST00000355622.8, ENST00000394487.5, ENST00000472304.2 )
Associated Disease
Coronary heart disease
Source Database
DisGeNET
Description
The TLR4/Asp299Gly and CD14/C-260T polymorphisms and plasma sCD14 concentrations do not appear as significant predictors of the risk of CHD in healthy individuals.
Pubmed
15367917
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.0079913664221677
Year of publication
2004
Drugs