chr11:118436456:> Detail (hg38)

Information

Genome

Assembly Position
hg19 chr11:118,307,171-118,397,547 
hg38 chr11:118,436,456-118,526,832

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.120 Carcinoma, Transitional Cell NA CTD_human Detail
<0.001 Cardiovascular Diseases NA BeFree Detail
<0.001 brain ischemia NA BeFree Detail
<0.001 Uterine Cervical Neoplasm NA BeFree Detail
0.120 Chromosome Aberrations NA CTD_human Detail
0.009 Congenital chromosomal disease Rearrangements of the MLL gene located at chromosome 11q23 are common chromosoma... BeFree 25031740 Detail
0.009 Congenital chromosomal disease Amplification of c-MYC, MLL and RUNX1 genes by means of fluorescence in situ hyb... BeFree 26214902 Detail
<0.001 colorectal carcinoma NA BeFree Detail
<0.001 Diabetic Nephropathy NA BeFree Detail
0.002 Down syndrome NA GAD Detail
0.001 Exanthema This patient expands the clinical phenotype associated with mutations in KMT2A t... BeFree 24818805 Detail
<0.001 fibrosarcoma NA BeFree Detail
<0.001 Glioma NA BeFree Detail
0.003 chronic granulomatous disease NA LHGDN Detail
0.002 Head and Neck Neoplasms NA GAD Detail
0.001 Hematological Disease Rearrangement of the mixed lineage-leukemia gene (MLL-r) is common in hematologi... BeFree 25843568 Detail
<0.001 hepatitis B NA BeFree Detail
<0.001 HIV Infections NA BeFree Detail
<0.001 hypertrichosis This patient expands the clinical phenotype associated with mutations in KMT2A t... BeFree 24818805 Detail
<0.001 Immunologic Deficiency Syndromes NA BeFree Detail
<0.001 ischemia Particularly, Grx2 and Trx1 showed distinct changes during tissue recovery follo... BeFree 25735211 Detail
<0.001 Kidney Diseases NA BeFree Detail
<0.001 chronic lymphocytic leukemia NA BeFree Detail
0.127 lymphoid leukemia MLL aberrations are detected in around 5-10% of acute myeloid and lymphatic leuk... BeFree,CTD_human,LHGDN 25510485 Detail
0.127 lymphoid leukemia High levels of SOCS2 characterize unfavorable subsets of acute myeloid and lymph... BeFree,CTD_human,LHGDN 25858143 Detail
0.053 Acute lymphocytic leukemia Acute lymphoblastic leukemia in infants (< 1 year-of-age) is characterized by a ... BeFree 24736461 Detail
0.053 Acute lymphocytic leukemia Rearrangements involving MLL gene are seen in CD10- B-ALL (pro-B cell origin) an... BeFree 24739837 Detail
0.053 Acute lymphocytic leukemia Distinct from other forms of acute lymphoblastic leukemia (ALL), infant ALL with... BeFree 24798483 Detail
0.053 Acute lymphocytic leukemia Early use of allogeneic hematopoietic stem cell transplantation for infants with... BeFree 24888273 Detail
0.053 Acute lymphocytic leukemia To date, this has mainly focused on ALL with MLL or ETV6-RUNX1 fusions, with hyp... BeFree 24897505 Detail
0.053 Acute lymphocytic leukemia Allogeneic haematopoietic stem cell transplantation for infant acute lymphoblast... BeFree 25302748 Detail
0.053 Acute lymphocytic leukemia Despite shortened therapy with early intensification, EFS remained less than 50%... BeFree 25399948 Detail
0.053 Acute lymphocytic leukemia The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic ... BeFree 25730765 Detail
0.053 Acute lymphocytic leukemia Identification of genes transcriptionally responsive to the loss of MLL fusions ... BeFree 25793396 Detail
0.053 Acute lymphocytic leukemia High levels of SOCS2 characterize unfavorable subsets of acute myeloid and lymph... BeFree 25858143 Detail
0.053 Acute lymphocytic leukemia The potential of clofarabine in MLL-rearranged infant acute lymphoblastic leukae... BeFree 26188848 Detail
0.007 Leukemia, Lymphocytic, Acute, L1 The aims of this multicenter study were to determine the prevalence of the four ... BeFree 25692130 Detail
0.007 Leukemia, Lymphocytic, Acute, L1 MLL-rearranged acute lymphoblastic leukaemia (ALL) in infants is the most diffic... BeFree 26188848 Detail
<0.001 Acute Megakaryocytic Leukemias NA BeFree Detail
0.121 acute biphenotypic leukemia NA BeFree,ORPHANET Detail
0.130 acute monocytic leukemia NA BeFree,CTD_human,LHGDN Detail
0.330 Leukemia, Myelocytic, Acute Rearrangements involving MLL gene are seen in CD10- B-ALL (pro-B cell origin) an... BeFree,CTD_human,GAD,LHGDN,MGD 24739837 Detail
0.330 Leukemia, Myelocytic, Acute Acute myeloid leukemias with MLL rearrangements are frequently associated with m... BeFree,CTD_human,GAD,LHGDN,MGD 25081372 Detail
0.330 Leukemia, Myelocytic, Acute Here, we report that deletion of the Hes1 gene in mice promotes acute myeloid le... BeFree,CTD_human,GAD,LHGDN,MGD 25234168 Detail
0.330 Leukemia, Myelocytic, Acute Overall, it has been clearly demonstrated that HOXA10 is transcriptionally regul... BeFree,CTD_human,GAD,LHGDN,MGD 25307539 Detail
0.330 Leukemia, Myelocytic, Acute Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute my... BeFree,CTD_human,GAD,LHGDN,MGD 25322685 Detail
0.330 Leukemia, Myelocytic, Acute Here, we report the first case in which a dominant Philadelphia chromosome-posit... BeFree,CTD_human,GAD,LHGDN,MGD 25401297 Detail
0.330 Leukemia, Myelocytic, Acute MLL aberrations are detected in around 5-10% of acute myeloid and lymphatic leuk... BeFree,CTD_human,GAD,LHGDN,MGD 25510485 Detail
0.330 Leukemia, Myelocytic, Acute Here, we apply single-cell analysis to systematically characterize the heterogen... BeFree,CTD_human,GAD,LHGDN,MGD 25517911 Detail
0.330 Leukemia, Myelocytic, Acute Our recent study identified a nonsense mutation of La-related protein 4B (LARP4B... BeFree,CTD_human,GAD,LHGDN,MGD 25534202 Detail
0.330 Leukemia, Myelocytic, Acute We examined the role of mutated Shp2 in leukemias harboring MLL translocations, ... BeFree,CTD_human,GAD,LHGDN,MGD 25650089 Detail
0.330 Leukemia, Myelocytic, Acute CXXC5 mRNA was downregulated in AML with MLL rearrangements, t(8;21) and GATA2 m... BeFree,CTD_human,GAD,LHGDN,MGD 25805812 Detail
0.330 Leukemia, Myelocytic, Acute A new variant of KMT2A(MLL)-FLNA fusion transcript in acute myeloid leukemia wit... BeFree,CTD_human,GAD,LHGDN,MGD 25892123 Detail
0.330 Leukemia, Myelocytic, Acute Amplification of c-MYC, MLL and RUNX1 genes by means of fluorescence in situ hyb... BeFree,CTD_human,GAD,LHGDN,MGD 26214902 Detail
0.330 Leukemia, Myelocytic, Acute RAS mutations in AML were found to coexist with other genetic aberrations, parti... BeFree,CTD_human,GAD,LHGDN,MGD 26222068 Detail
0.330 Leukemia, Myelocytic, Acute The transcriptomic landscape and directed chemical interrogation of MLL-rearrang... BeFree,CTD_human,GAD,LHGDN,MGD 26237430 Detail
0.134 myeloid leukemia NA BeFree,CTD_human,GAD Detail
<0.001 Myeloid Leukemia, Chronic NA BeFree Detail
0.125 acute myelomonocytic leukemia NA BeFree,CTD_human,LHGDN Detail
0.003 Leukemia, Myelomonocytic, Chronic NA BeFree,LHGDN Detail
<0.001 chronic neutrophilic leukemia NA BeFree Detail
<0.001 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma NA BeFree Detail
0.001 acute promyelocytic leukemia NA BeFree Detail
<0.001 Leukemia, T-Cell NA BeFree Detail
0.002 lymphoma This is the first report of submicroscopic bone marrow involvement in MLL-rearra... BeFree 24635731 Detail
0.002 lymphoma Sixty-two infants with MLL gene-rearrangement-positive acute lymphoblastic leuke... BeFree 24888273 Detail
<0.001 Lymphoma, Follicular NA BeFree Detail
<0.001 Malignant neoplasm of stomach Mutations in chromatin remodeling genes (ARID1A, MLL3 and MLL) have been found i... BeFree 24744582 Detail
<0.001 melanoma NA BeFree Detail
<0.001 meningioma NA BeFree Detail
<0.001 Metabolic Diseases NA BeFree Detail
0.001 Monosomy NA BeFree Detail
<0.001 multiple myeloma NA BeFree Detail
<0.001 multiple sclerosis NA BeFree Detail
<0.001 Mycoses NA BeFree Detail
<0.001 Myelodysplasia NA BeFree Detail
<0.001 Acute Myeloid Leukemia, M1 NA BeFree Detail
<0.001 Myelomonocytic leukemia NA BeFree Detail
<0.001 Myeloproliferative disease NA BeFree Detail
<0.001 myocardial infarction NA BeFree Detail
<0.001 Neoplasm Metastasis NA BeFree Detail
0.002 Neoplasm Recurrence, Local NA GAD Detail
<0.001 nephroblastoma The expression of the MLL gene had a higher specificity and sensitivity than WT1... BeFree 24631740 Detail
<0.001 neuroblastoma NA BeFree Detail
<0.001 ovarian carcinoma Here we showed that Trx1 and FOXO1 were involved in paclitaxel (PTX)-induced dru... BeFree 25483711 Detail
<0.001 pancytopenia NA BeFree Detail
<0.001 Pregnancy in Diabetics NA BeFree Detail
0.005 Preleukemia NA BeFree,GAD Detail
0.003 schizophrenia NA BeFree,LHGDN Detail
<0.001 Dermatologic disorders NA BeFree Detail
0.120 Stomach Neoplasms NA CTD_human Detail
<0.001 Trisomy NA BeFree Detail
<0.001 urinary tract infection NA BeFree Detail
<0.001 B-Cell Lymphomas NA BeFree Detail
<0.001 diffuse large B-cell lymphoma NA BeFree Detail
0.001 Precursor cell lymphoblastic lymphoma The role of MLL gene deregulation in rare cases of isolated lymphoblastic lympho... BeFree 24635731 Detail
0.001 Precursor cell lymphoblastic lymphoma Bilateral ovarian B-lineage lymphoblastic lymphoma with MLL gene rearrangement: ... BeFree 25493458 Detail
0.003 Neoplasms, Second Primary NA BeFree,GAD Detail
0.048 acute leukemia To evaluate the prognostic value of the expression of the mixed lineage leukemia... BeFree 24631740 Detail
0.048 acute leukemia Precursor B-lymphoblastic lymphoma cells are indistinguishable by morphology, an... BeFree 24635731 Detail
0.048 acute leukemia Rearrangements of the MLL gene involve multiple partners and are implicated in b... BeFree 24787275 Detail
0.048 acute leukemia Rearrangements of the MLL gene located at chromosome 11q23 are common chromosoma... BeFree 25031740 Detail
0.048 acute leukemia Evidence-based RT-PCR methods for the detection of the 8 most common MLL aberrat... BeFree 25510485 Detail
0.048 acute leukemia Translocation of the mixed-lineage leukemia (MLL) gene with AF4, AF9, or ENL res... BeFree 25538041 Detail
0.048 acute leukemia MLL (mixed-lineage-leukemia) gene rearrangements are typical for acute leukemia ... BeFree 25699572 Detail
0.048 acute leukemia Chromosomal rearrangements of the MLL gene are associated with high-risk infant,... BeFree 25740345 Detail
0.048 acute leukemia We conclude that the here identified genes readily responsive to the loss of MLL... BeFree 25793396 Detail
0.048 acute leukemia Acute leukemias with KMT2A rearrangements have different prognoses, which depend... BeFree 25892123 Detail
0.048 acute leukemia They act as dominant cooperating oncoproteins that cause acute leukemias bearing... BeFree 26059450 Detail
0.120 Small cell carcinoma of lung NA CTD_human Detail
<0.001 Thyroid Gland Follicular Adenoma Consistently, an inverse correlation between miR-142-3p expression and ASH1L and... BeFree 25238203 Detail
0.004 Granulocytic Sarcoma NA BeFree,LHGDN Detail
<0.001 Malignant neoplasm of testis NA BeFree Detail
<0.001 Tumor Progression NA BeFree Detail
<0.001 follicular adenoma Consistently, an inverse correlation between miR-142-3p expression and ASH1L and... BeFree 25238203 Detail
0.003 Adult Acute Myeloblastic Leukemia The specific t(10;11)(p12;q23) MLL translocation is a rare recurrent translocati... BeFree 25081372 Detail
0.003 pediatric acute myeloblastic leukemia Rearrangements involving MLL gene are seen in CD10- B-ALL (pro-B cell origin) an... BeFree 24739837 Detail
<0.001 Retinal damage NA BeFree Detail
0.011 Neoplasm, Residual The expression of the MLL gene had a higher specificity and sensitivity than WT1... BeFree,LHGDN 24631740 Detail
0.011 Neoplasm, Residual Simultaneously, real-time quantitative RT-PCR detected a low copy number of MLL-... BeFree,LHGDN 24813938 Detail
0.011 Neoplasm, Residual MLL rearrangements are important for therapy stratification, assessment of minim... BeFree,LHGDN 25510485 Detail
0.001 Miller Dieker syndrome NA BeFree Detail
<0.001 Cornelia de Lange syndrome Extensive clinical evaluation and WES of 32 Turkish patients clinically diagnose... BeFree 25574841 Detail
<0.001 Disseminated neuroblastoma NA BeFree Detail
<0.001 Malignant Childhood Neoplasm NA BeFree Detail
0.001 Solid tumour NA BeFree Detail
0.002 Acute Undifferentiated Leukemia The H3K4-specific demethylase KDM5B negatively regulates leukemogenesis in murin... BeFree 26190263 Detail
0.002 secondary acute myeloid leukemia NA BeFree Detail
<0.001 de novo myelodysplastic syndromes NA BeFree Detail
<0.001 secondary myelodysplastic syndromes NA BeFree Detail
<0.001 leukostasis Acute myeloid leukemias with MLL rearrangements are frequently associated with m... BeFree 25081372 Detail
<0.001 Angioendotheliomatosis NA BeFree Detail
<0.001 Common acute lymphoblastic leukemia NA BeFree Detail
<0.001 juvenile myelomonocytic leukemia NA BeFree Detail
0.120 Acute bilineal leukemia NA ORPHANET Detail
0.001 Malignant neoplasm of prostate We studied the effects of 0-80 mmHg increased extracellular pressure for 24 h on... BeFree 25454347 Detail
0.001 Hematopoietic Neoplasms NA BeFree Detail
0.004 Hematologic Neoplasms NA BeFree Detail
0.005 Trisomy 11 NA BeFree Detail
0.001 Chromosome 8, trisomy The aim of our study was 1) to define if the amplification of c-MYC, MLL and RUN... BeFree 26214902 Detail
0.001 Chromosome 8, trisomy The MLL gene rearrangements were found in 6.6% of patients, the -5/ 5q- and/ or ... BeFree 26299742 Detail
0.002 Acute monoblastic leukemia NA BeFree Detail
<0.001 Carcinoma of larynx We analyzed the expression profile of 5 MLL genes in 13 cases of larynx carcinom... BeFree 25633166 Detail
0.003 Carcinogenesis Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis. BeFree 25267403 Detail
0.023 Leukemogenesis The hyperactive Shp2E76K mutant, commonly observed in leukemia patients, signifi... BeFree 25650089 Detail
0.023 Leukemogenesis This review focuses on the molecular mechanisms underlying MLL1 translocation-dr... BeFree 26118503 Detail
0.023 Leukemogenesis The H3K4-specific demethylase KDM5B negatively regulates leukemogenesis in murin... BeFree 26190263 Detail
<0.001 monocytic leukemia NA BeFree Detail
<0.001 Tumor Initiation NA BeFree Detail
<0.001 prostate carcinoma We studied the effects of 0-80 mmHg increased extracellular pressure for 24 h on... BeFree 25454347 Detail
0.240 leukemia In mice, tamoxifen treatment blocked development of JAK2(V617F)-induced myelopro... BeFree 25479752 Detail
0.002 breast carcinoma NA BeFree Detail
<0.001 stomach carcinoma Mutations in chromatin remodeling genes (ARID1A, MLL3 and MLL) have been found i... BeFree 24744582 Detail
<0.001 Central neuroblastoma NA BeFree Detail
0.002 adult acute lymphocytic leukemia We found a significantly increased expression of p16(INK4A) in BCP-ALLs with MLL... BeFree 25675863 Detail
<0.001 Chromosome 6, monosomy 6q NA BeFree Detail
<0.001 Spots on skin NA BeFree Detail
<0.001 Small Lymphocytic Lymphoma NA BeFree Detail
<0.001 Precursor B-lymphoblastic lymphoma Precursor B-lymphoblastic lymphoma cells are indistinguishable by morphology, an... BeFree 24635731 Detail
0.003 Leukemia secondary NA BeFree Detail
<0.001 Philadelphia chromosome positive Here, we report the first case in which a dominant Philadelphia chromosome-posit... BeFree 25401297 Detail
0.120 Undifferentiated type acute leukemia NA ORPHANET Detail
<0.001 Precursor B-lymphoblastic lymphoma stage II Complex MLL rearrangement in non-infiltrated bone marrow in an infant with stage... BeFree 24635731 Detail
<0.001 Stage 4S neuroblastoma NA BeFree Detail
<0.001 Malignant neoplasm of ovary Here we showed that Trx1 and FOXO1 were involved in paclitaxel (PTX)-induced dru... BeFree 25483711 Detail
0.009 Precursor B-cell lymphoblastic leukemia Rearrangements involving MLL gene are seen in CD10- B-ALL (pro-B cell origin) an... BeFree 24739837 Detail
0.120 Acute myeloid leukemia, 11q23 abnormalities NA ORPHANET Detail
<0.001 Therapy-related myelodysplastic syndrome NA BeFree Detail
<0.001 blastic plasmacytoid dendritic cell neoplasm KMT2A (MLL)-MLLT1 rearrangement in blastic plasmacytoid dendritic cell neoplasm. BeFree 26164398 Detail
0.005 M5b Acute differentiated monocytic leukemia NA BeFree Detail
<0.001 Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome NA BeFree Detail
<0.001 Central nervous system leukaemia NA BeFree Detail
0.003 childhood leukemia We validated GIPFEL for the five most common gene fusions associated with childh... BeFree 25137060 Detail
0.003 childhood leukemia The mixed-lineage leukemia family of histone methyltransferases (MLL1-4, or KMT2... BeFree 25794446 Detail
<0.001 childhood lymphoma Mixed-lineage leukemia (MLL) gene rearrangements have rarely been reported in pe... BeFree 25493458 Detail
0.007 Treatment related acute myeloid leukaemia NA BeFree Detail
0.001 Undifferentiated leukemia The H3K4-specific demethylase KDM5B negatively regulates leukemogenesis in murin... BeFree 26190263 Detail
<0.001 Mammary Neoplasms NA BeFree Detail
<0.001 colorectal cancer NA BeFree Detail
<0.001 Meningioma, benign, no ICD-O subtype NA BeFree Detail
<0.001 MYELOID TUMOR SUPPRESSOR NA BeFree Detail
0.003 MULTICYSTIC RENAL DYSPLASIA, BILATERAL Simultaneously, real-time quantitative RT-PCR detected a low copy number of MLL-... BeFree 24813938 Detail
0.002 Glucocorticoid Receptor Deficiency NA BeFree Detail
0.241 Growth Deficiency and Mental Retardation with Facial Dysmorphism Advanced bone age in a girl with Wiedemann-Steiner syndrome and an exonic deleti... BeFree,CLINVAR,ORPHANET 24818805 Detail
0.241 Growth Deficiency and Mental Retardation with Facial Dysmorphism Extensive clinical evaluation and WES of 32 Turkish patients clinically diagnose... BeFree,CLINVAR,ORPHANET 25574841 Detail
<0.001 Acute Myeloid Leukemia (AML-M2) NA BeFree Detail
0.004 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma They act as dominant cooperating oncoproteins that cause acute leukemias bearing... BeFree 26059450 Detail
0.274 Precursor Cell Lymphoblastic Leukemia Lymphoma The role of MLL gene deregulation in rare cases of isolated lymphoblastic lympho... BeFree,CTD_human,LHGDN,MGD 24635731 Detail
0.274 Precursor Cell Lymphoblastic Leukemia Lymphoma Acute lymphoblastic leukemia in infants (< 1 year-of-age) is characterized by a ... BeFree,CTD_human,LHGDN,MGD 24736461 Detail
0.274 Precursor Cell Lymphoblastic Leukemia Lymphoma Rearrangements involving MLL gene are seen in CD10- B-ALL (pro-B cell origin) an... BeFree,CTD_human,LHGDN,MGD 24739837 Detail
0.274 Precursor Cell Lymphoblastic Leukemia Lymphoma Distinct from other forms of acute lymphoblastic leukemia (ALL), infant ALL with... BeFree,CTD_human,LHGDN,MGD 24798483 Detail
0.274 Precursor Cell Lymphoblastic Leukemia Lymphoma Early use of allogeneic hematopoietic stem cell transplantation for infants with... BeFree,CTD_human,LHGDN,MGD 24888273 Detail
0.274 Precursor Cell Lymphoblastic Leukemia Lymphoma Despite shortened therapy with early intensification, EFS remained less than 50%... BeFree,CTD_human,LHGDN,MGD 25399948 Detail
0.274 Precursor Cell Lymphoblastic Leukemia Lymphoma Bilateral ovarian B-lineage lymphoblastic lymphoma with MLL gene rearrangement: ... BeFree,CTD_human,LHGDN,MGD 25493458 Detail
0.274 Precursor Cell Lymphoblastic Leukemia Lymphoma The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic ... BeFree,CTD_human,LHGDN,MGD 25730765 Detail
0.274 Precursor Cell Lymphoblastic Leukemia Lymphoma Identification of genes transcriptionally responsive to the loss of MLL fusions ... BeFree,CTD_human,LHGDN,MGD 25793396 Detail
0.274 Precursor Cell Lymphoblastic Leukemia Lymphoma High levels of SOCS2 characterize unfavorable subsets of acute myeloid and lymph... BeFree,CTD_human,LHGDN,MGD 25858143 Detail
0.121 liver carcinoma NA BeFree,CTD_human Detail
<0.001 Myeloblastic leukemia NA BeFree Detail
0.001 Hyperdiploid B Acute Lymphoblastic Leukemia NA BeFree Detail
<0.001 Promyelocytic leukemia NA BeFree Detail
<0.001 acute myeloid leukemia with myelodysplasia-related changes NA BeFree Detail
0.004 Treatment related leukaemia NA BeFree Detail
<0.001 Mixed phenotype acute leukemia NA BeFree Detail
<0.001 myeloid neoplasm Homozygous inv(11)(q21q23) and MLL gene rearrangement in two patients with myelo... BeFree 25031740 Detail
0.008 myelodysplastic syndrome NA BeFree,GAD,LHGDN Detail
0.120 Leukemia, acute lymphoblastic, susceptibility to, 3 NA ORPHANET Detail
<0.001 Leukemia in children NA BeFree Detail
0.001 Cytogenetically normal acute myeloid leukemia NA BeFree Detail
<0.001 Congenital Abnormality NA BeFree Detail
0.120 adenocarcinoma NA CTD_human Detail
<0.001 arteriosclerosis NA BeFree Detail
<0.001 rheumatoid arthritis NA BeFree Detail
<0.001 atherosclerosis NA BeFree Detail
0.120 Bladder Neoplasm NA CTD_human Detail
<0.001 Blast Phase NA BeFree Detail
0.002 Malignant neoplasm of breast NA BeFree Detail
<0.001 bronchopulmonary dysplasia These data support the hypothesis that hyperoxic impairment of Trx1 has a negati... BeFree 25106706 Detail
0.003 Burkitt lymphoma NA LHGDN Detail
<0.001 Malignant tumor of colon NA BeFree Detail
<0.001 Malignant neoplasm of larynx In conclusion, MLL genes may have similar transcriptional control, and decreased... BeFree 25633166 Detail
<0.001 Non-small cell lung carcinoma NA BeFree Detail
<0.001 renal cell carcinoma NA BeFree Detail
Annotation

Annotations

DescrptionSourceLinks
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Rearrangements of the MLL gene located at chromosome 11q23 are common chromosomal abnormalities asso... DisGeNET Detail
Amplification of c-MYC, MLL and RUNX1 genes by means of fluorescence in situ hybridization (FISH) wa... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
This patient expands the clinical phenotype associated with mutations in KMT2A to include variable p... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Rearrangement of the mixed lineage-leukemia gene (MLL-r) is common in hematological diseases and is ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
This patient expands the clinical phenotype associated with mutations in KMT2A to include variable p... DisGeNET Detail
NA DisGeNET Detail
Particularly, Grx2 and Trx1 showed distinct changes during tissue recovery following hypoxia/ischemi... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
MLL aberrations are detected in around 5-10% of acute myeloid and lymphatic leukemias and an additio... DisGeNET Detail
High levels of SOCS2 characterize unfavorable subsets of acute myeloid and lymphoblastic leukemias, ... DisGeNET Detail
Acute lymphoblastic leukemia in infants (< 1 year-of-age) is characterized by a high incidence of ML... DisGeNET Detail
Rearrangements involving MLL gene are seen in CD10- B-ALL (pro-B cell origin) and t(9;11)(p21;q23) i... DisGeNET Detail
Distinct from other forms of acute lymphoblastic leukemia (ALL), infant ALL with mixed lineage leuke... DisGeNET Detail
Early use of allogeneic hematopoietic stem cell transplantation for infants with MLL gene-rearrangem... DisGeNET Detail
To date, this has mainly focused on ALL with MLL or ETV6-RUNX1 fusions, with hyperdiploid ALL remain... DisGeNET Detail
Allogeneic haematopoietic stem cell transplantation for infant acute lymphoblastic leukaemia with KM... DisGeNET Detail
Despite shortened therapy with early intensification, EFS remained less than 50% overall in MLL-R AL... DisGeNET Detail
The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias. DisGeNET Detail
Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged ac... DisGeNET Detail
High levels of SOCS2 characterize unfavorable subsets of acute myeloid and lymphoblastic leukemias, ... DisGeNET Detail
The potential of clofarabine in MLL-rearranged infant acute lymphoblastic leukaemia. DisGeNET Detail
The aims of this multicenter study were to determine the prevalence of the four most common gene rea... DisGeNET Detail
MLL-rearranged acute lymphoblastic leukaemia (ALL) in infants is the most difficult-to-treat type of... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Rearrangements involving MLL gene are seen in CD10- B-ALL (pro-B cell origin) and t(9;11)(p21;q23) i... DisGeNET Detail
Acute myeloid leukemias with MLL rearrangements are frequently associated with myelomonocytic and mo... DisGeNET Detail
Here, we report that deletion of the Hes1 gene in mice promotes acute myeloid leukemia (AML) develop... DisGeNET Detail
Overall, it has been clearly demonstrated that HOXA10 is transcriptionally regulated by MLL1, which,... DisGeNET Detail
Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute myeloid leukemia. DisGeNET Detail
Here, we report the first case in which a dominant Philadelphia chromosome-positive subclone was det... DisGeNET Detail
MLL aberrations are detected in around 5-10% of acute myeloid and lymphatic leukemias and an additio... DisGeNET Detail
Here, we apply single-cell analysis to systematically characterize the heterogeneity within leukemic... DisGeNET Detail
Our recent study identified a nonsense mutation of La-related protein 4B (LARP4B) from whole genome ... DisGeNET Detail
We examined the role of mutated Shp2 in leukemias harboring MLL translocations, which co-occur in hu... DisGeNET Detail
CXXC5 mRNA was downregulated in AML with MLL rearrangements, t(8;21) and GATA2 mutations. DisGeNET Detail
A new variant of KMT2A(MLL)-FLNA fusion transcript in acute myeloid leukemia with ins(X;11)(q28;q23q... DisGeNET Detail
Amplification of c-MYC, MLL and RUNX1 genes by means of fluorescence in situ hybridization (FISH) wa... DisGeNET Detail
RAS mutations in AML were found to coexist with other genetic aberrations, particularly MLL rearrang... DisGeNET Detail
The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leu... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
This is the first report of submicroscopic bone marrow involvement in MLL-rearranged isolated cutane... DisGeNET Detail
Sixty-two infants with MLL gene-rearrangement-positive acute lymphoblastic leukemia (MLL-r ALL) were... DisGeNET Detail
NA DisGeNET Detail
Mutations in chromatin remodeling genes (ARID1A, MLL3 and MLL) have been found in 47% of GCs. DisGeNET Detail
NA DisGeNET Detail
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NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The expression of the MLL gene had a higher specificity and sensitivity than WT1 or MRD monitored by... DisGeNET Detail
NA DisGeNET Detail
Here we showed that Trx1 and FOXO1 were involved in paclitaxel (PTX)-induced drug resistance in ovar... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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The role of MLL gene deregulation in rare cases of isolated lymphoblastic lymphoma in infants is obs... DisGeNET Detail
Bilateral ovarian B-lineage lymphoblastic lymphoma with MLL gene rearrangement: a novel case in infa... DisGeNET Detail
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To evaluate the prognostic value of the expression of the mixed lineage leukemia (MLL) gene for pred... DisGeNET Detail
Precursor B-lymphoblastic lymphoma cells are indistinguishable by morphology, and immune phenotype f... DisGeNET Detail
Rearrangements of the MLL gene involve multiple partners and are implicated in both therapy related ... DisGeNET Detail
Rearrangements of the MLL gene located at chromosome 11q23 are common chromosomal abnormalities asso... DisGeNET Detail
Evidence-based RT-PCR methods for the detection of the 8 most common MLL aberrations in acute leukem... DisGeNET Detail
Translocation of the mixed-lineage leukemia (MLL) gene with AF4, AF9, or ENL results in acute leukem... DisGeNET Detail
MLL (mixed-lineage-leukemia) gene rearrangements are typical for acute leukemia and are associated w... DisGeNET Detail
Chromosomal rearrangements of the MLL gene are associated with high-risk infant, pediatric, adult, a... DisGeNET Detail
We conclude that the here identified genes readily responsive to the loss of MLL fusion expression p... DisGeNET Detail
Acute leukemias with KMT2A rearrangements have different prognoses, which depend on the partner gene... DisGeNET Detail
They act as dominant cooperating oncoproteins that cause acute leukemias bearing MLL translocations ... DisGeNET Detail
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Consistently, an inverse correlation between miR-142-3p expression and ASH1L and MLL1 proteins was f... DisGeNET Detail
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Consistently, an inverse correlation between miR-142-3p expression and ASH1L and MLL1 proteins was f... DisGeNET Detail
The specific t(10;11)(p12;q23) MLL translocation is a rare recurrent translocation partner, most com... DisGeNET Detail
Rearrangements involving MLL gene are seen in CD10- B-ALL (pro-B cell origin) and t(9;11)(p21;q23) i... DisGeNET Detail
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The expression of the MLL gene had a higher specificity and sensitivity than WT1 or MRD monitored by... DisGeNET Detail
Simultaneously, real-time quantitative RT-PCR detected a low copy number of MLL-AF9 transcripts, con... DisGeNET Detail
MLL rearrangements are important for therapy stratification, assessment of minimal residual disease ... DisGeNET Detail
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Extensive clinical evaluation and WES of 32 Turkish patients clinically diagnosed with CdLS revealed... DisGeNET Detail
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The H3K4-specific demethylase KDM5B negatively regulates leukemogenesis in murine and human MLL-rear... DisGeNET Detail
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Acute myeloid leukemias with MLL rearrangements are frequently associated with myelomonocytic and mo... DisGeNET Detail
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We studied the effects of 0-80 mmHg increased extracellular pressure for 24 h on proliferation of SW... DisGeNET Detail
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The aim of our study was 1) to define if the amplification of c-MYC, MLL and RUNX1 genes is related ... DisGeNET Detail
The MLL gene rearrangements were found in 6.6% of patients, the -5/ 5q- and/ or -7/ 7q- aberrations ... DisGeNET Detail
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We analyzed the expression profile of 5 MLL genes in 13 cases of larynx carcinoma and their adjacent... DisGeNET Detail
Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis. DisGeNET Detail
The hyperactive Shp2E76K mutant, commonly observed in leukemia patients, significantly accelerated M... DisGeNET Detail
This review focuses on the molecular mechanisms underlying MLL1 translocation-driven leukemogenesis ... DisGeNET Detail
The H3K4-specific demethylase KDM5B negatively regulates leukemogenesis in murine and human MLL-rear... DisGeNET Detail
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We studied the effects of 0-80 mmHg increased extracellular pressure for 24 h on proliferation of SW... DisGeNET Detail
In mice, tamoxifen treatment blocked development of JAK2(V617F)-induced myeloproliferative neoplasm ... DisGeNET Detail
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Mutations in chromatin remodeling genes (ARID1A, MLL3 and MLL) have been found in 47% of GCs. DisGeNET Detail
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We found a significantly increased expression of p16(INK4A) in BCP-ALLs with MLL rearrangement. DisGeNET Detail
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Precursor B-lymphoblastic lymphoma cells are indistinguishable by morphology, and immune phenotype f... DisGeNET Detail
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Here, we report the first case in which a dominant Philadelphia chromosome-positive subclone was det... DisGeNET Detail
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Complex MLL rearrangement in non-infiltrated bone marrow in an infant with stage II precursor B-lymp... DisGeNET Detail
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Here we showed that Trx1 and FOXO1 were involved in paclitaxel (PTX)-induced drug resistance in ovar... DisGeNET Detail
Rearrangements involving MLL gene are seen in CD10- B-ALL (pro-B cell origin) and t(9;11)(p21;q23) i... DisGeNET Detail
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KMT2A (MLL)-MLLT1 rearrangement in blastic plasmacytoid dendritic cell neoplasm. DisGeNET Detail
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We validated GIPFEL for the five most common gene fusions associated with childhood leukemia (MLL-AF... DisGeNET Detail
The mixed-lineage leukemia family of histone methyltransferases (MLL1-4, or KMT2A-D) were previously... DisGeNET Detail
Mixed-lineage leukemia (MLL) gene rearrangements have rarely been reported in pediatric lymphoma des... DisGeNET Detail
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The H3K4-specific demethylase KDM5B negatively regulates leukemogenesis in murine and human MLL-rear... DisGeNET Detail
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Simultaneously, real-time quantitative RT-PCR detected a low copy number of MLL-AF9 transcripts, con... DisGeNET Detail
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Advanced bone age in a girl with Wiedemann-Steiner syndrome and an exonic deletion in KMT2A (MLL). DisGeNET Detail
Extensive clinical evaluation and WES of 32 Turkish patients clinically diagnosed with CdLS revealed... DisGeNET Detail
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They act as dominant cooperating oncoproteins that cause acute leukemias bearing MLL translocations ... DisGeNET Detail
The role of MLL gene deregulation in rare cases of isolated lymphoblastic lymphoma in infants is obs... DisGeNET Detail
Acute lymphoblastic leukemia in infants (< 1 year-of-age) is characterized by a high incidence of ML... DisGeNET Detail
Rearrangements involving MLL gene are seen in CD10- B-ALL (pro-B cell origin) and t(9;11)(p21;q23) i... DisGeNET Detail
Distinct from other forms of acute lymphoblastic leukemia (ALL), infant ALL with mixed lineage leuke... DisGeNET Detail
Early use of allogeneic hematopoietic stem cell transplantation for infants with MLL gene-rearrangem... DisGeNET Detail
Despite shortened therapy with early intensification, EFS remained less than 50% overall in MLL-R AL... DisGeNET Detail
Bilateral ovarian B-lineage lymphoblastic lymphoma with MLL gene rearrangement: a novel case in infa... DisGeNET Detail
The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias. DisGeNET Detail
Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged ac... DisGeNET Detail
High levels of SOCS2 characterize unfavorable subsets of acute myeloid and lymphoblastic leukemias, ... DisGeNET Detail
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Homozygous inv(11)(q21q23) and MLL gene rearrangement in two patients with myeloid neoplasms. DisGeNET Detail
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These data support the hypothesis that hyperoxic impairment of Trx1 has a negative impact on HSP90-o... DisGeNET Detail
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In conclusion, MLL genes may have similar transcriptional control, and decreased expression of these... DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386626619 dbSNP
Genome
hg38
Position
chr11:118,436,456-118,526,832
Variant Type
snv
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