chr4:38797876:> Detail (hg19)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr4:38,797,876-38,806,412 |
| hg38 | chr4:38,796,255-38,804,791 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| <0.001 | squamous cell carcinoma | NA | BeFree | Detail | |
| <0.001 | Cervix Diseases | NA | BeFree | Detail | |
| 0.002 | Chagas Cardiomyopathy | NA | GAD | Detail | |
| <0.001 | Chediak-Higashi syndrome | At baseline, we found CD14, IL1R1 and TLR-1 were down-regulated significantly (≥... | BeFree | 25528552 | Detail |
| 0.002 | chorioamnionitis | NA | GAD | Detail | |
| 0.003 | ulcerative colitis | NA | BeFree,GAD | Detail | |
| <0.001 | Non-small cell lung carcinoma | Among the 178 SNPs, 24 were significantly associated with NSCLC prognosis in dif... | BeFree | 21412764 | Detail |
| <0.001 | colorectal carcinoma | NA | BeFree | Detail | |
| 0.002 | Crohn Disease | NA | GAD | Detail | |
| 0.002 | cystitis | NA | GAD | Detail | |
| 0.003 | Cessation of life | NA | LHGDN | Detail | |
| 0.003 | Dermatitis, Atopic | NA | BeFree,GAD | Detail | |
| <0.001 | Diabetes Mellitus, Insulin-Dependent | Our study, for the first time, indicates that TLR1 and TLR6 gene might play impo... | BeFree | 25261617 | Detail |
| <0.001 | Eczema | NA | BeFree | Detail | |
| 0.003 | Filarial Elephantiases | NA | LHGDN | Detail | |
| <0.001 | Erythema Chronicum Migrans | NA | BeFree | Detail | |
| 0.002 | Fetal Membranes, Premature Rupture | NA | GAD | Detail | |
| 0.120 | IgA glomerulonephritis | NA | BeFree,CTD_human | Detail | |
| <0.001 | Glossitis, Benign Migratory | NA | BeFree | Detail | |
| 0.003 | Granuloma | NA | LHGDN | Detail | |
| <0.001 | Graves Disease | Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease. | BeFree | 25028161 | Detail |
| 0.122 | Hay fever | NA | GAD,GWASCAT | Detail | |
| <0.001 | Severe Dengue | NA | BeFree | Detail | |
| <0.001 | HIV Infections | NA | BeFree | Detail | |
| 0.002 | Hypersensitivity | NA | GAD | Detail | |
| <0.001 | Ileal Diseases | NA | BeFree | Detail | |
| <0.001 | Inflammatory Bowel Diseases | NA | BeFree | Detail | |
| 0.002 | Premature Obstetric Labor | NA | GAD | Detail | |
| <0.001 | Legionnaires' disease | NA | BeFree | Detail | |
| 0.128 | leprosy | NA | BeFree,CTD_human,GAD | Detail | |
| 0.001 | Tuberculosis, Pulmonary | In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile... | BeFree | 20797905 | Detail |
| 0.003 | lymphoma | NA | BeFree,GAD | Detail | |
| 0.003 | Lymphoma, Non-Hodgkin | NA | BeFree,GAD | Detail | |
| 0.003 | malaria | NA | BeFree,GAD | Detail | |
| 0.005 | Malaria, Falciparum | NA | GAD | Detail | |
| <0.001 | Malignant neoplasm of stomach | NA | BeFree | Detail | |
| 0.003 | melanoma | Collectively, our results show that TIGIT and PD-1 regulate the expansion and fu... | BeFree | 25866972 | Detail |
| <0.001 | melioidosis | NA | BeFree | Detail | |
| 0.002 | Meningeal Neoplasms | NA | GAD | Detail | |
| 0.002 | meningioma | NA | GAD | Detail | |
| 0.002 | multiple myeloma | NA | GAD | Detail | |
| 0.005 | multiple sclerosis | NA | GAD | Detail | |
| <0.001 | Mycobacterium Infections | NA | BeFree | Detail | |
| <0.001 | Mycoses | NA | BeFree | Detail | |
| <0.001 | Neoplasm Metastasis | NA | BeFree | Detail | |
| <0.001 | Neurosyphilis | A common TLR1 polymorphism is associated with an increased risk of laboratory-de... | BeFree | 24922103 | Detail |
| <0.001 | Osteitis | The TLR1 variant genotype was associated with a lower risk of BCG osteitis (aOR ... | BeFree | 25605403 | Detail |
| <0.001 | Degenerative polyarthritis | NA | BeFree | Detail | |
| <0.001 | ovarian carcinoma | NA | BeFree | Detail | |
| 0.002 | pre-eclampsia | NA | GAD | Detail | |
| 0.002 | Pregnancy Complications, Infectious | NA | GAD | Detail | |
| 0.008 | Prostatic Neoplasms | NA | LHGDN | Detail | |
| 0.002 | Puerperal Disorders | NA | GAD | Detail | |
| 0.003 | pyelonephritis | NA | BeFree,GAD | Detail | |
| 0.005 | Respiratory Syncytial Virus Infections | NA | GAD | Detail | |
| 0.002 | Rhinitis, Allergic, Perennial | NA | GAD | Detail | |
| <0.001 | Gram positive sepsis | NA | BeFree | Detail | |
| <0.001 | Septicemia | NA | BeFree | Detail | |
| <0.001 | Stomach Diseases | NA | BeFree | Detail | |
| <0.001 | gastric ulcer | NA | BeFree | Detail | |
| 0.002 | Streptococcal Infections | NA | GAD | Detail | |
| <0.001 | syphilis | Polymorphisms in the genes for TLR1 (a T→G mutation at position 1805), TLR2 (a G... | BeFree | 24922103 | Detail |
| 0.002 | Ocular Toxoplasmosis | NA | GAD | Detail | |
| 0.001 | Tuberculosis, Pulmonary | NA | BeFree | Detail | |
| 0.005 | urinary tract infection | NA | GAD | Detail | |
| <0.001 | Lymphoma, Large-Cell, Follicular | NA | BeFree | Detail | |
| <0.001 | severe combined immunodeficiency | NA | BeFree | Detail | |
| 0.002 | bacterial vaginosis | NA | GAD | Detail | |
| 0.002 | Gram-Positive Bacterial Infections | NA | GAD | Detail | |
| 0.002 | Premature Birth | NA | GAD | Detail | |
| 0.002 | Pregnancy Complications, Parasitic | NA | GAD | Detail | |
| <0.001 | Tumor Progression | NA | BeFree | Detail | |
| <0.001 | Neuroectodermal Tumor, Primitive | The present study aimed to investigate biomarkers of PNETs in the primary diseas... | BeFree | 25310565 | Detail |
| <0.001 | invasive aspergillosis | NA | BeFree | Detail | |
| <0.001 | Papillary thyroid carcinoma | NA | BeFree | Detail | |
| <0.001 | pelvic inflammatory disease | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of lung | We mainly elucidate that miRNA-15a/16 can enhance radiation sensitivity by regul... | BeFree | 25442346 | Detail |
| <0.001 | Lyme Arthritis | NA | BeFree | Detail | |
| <0.001 | Mucosa-Associated Lymphoid Tissue Lymphoma | NA | BeFree | Detail | |
| 0.003 | Parasitemia | NA | BeFree,GAD | Detail | |
| 0.011 | Sepsis | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | Carcinoma of ampulla of Vater | NA | BeFree | Detail | |
| <0.001 | Asymptomatic Infections | NA | BeFree | Detail | |
| <0.001 | Extreme exhaustion | Moreover, the polymorphisms in the toll-like receptor 1 (TLR1) and TLR2 genes va... | BeFree | 25200597 | Detail |
| <0.001 | Metastatic melanoma | NA | BeFree | Detail | |
| <0.001 | Liver and Intrahepatic Biliary Tract Carcinoma | NA | BeFree | Detail | |
| <0.001 | Squamous cell carcinoma of esophagus | NA | BeFree | Detail | |
| <0.001 | cervical squamous cell carcinoma | A significant downregulation in the gene expression of TLRs 3, 4 and 5 and upreg... | BeFree | 26024767 | Detail |
| <0.001 | extraosseous Ewings sarcoma-primitive neuroepithelial tumor | The present study aimed to investigate biomarkers of PNETs in the primary diseas... | BeFree | 25310565 | Detail |
| <0.001 | Leprosy reversal reaction | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of liver | NA | BeFree | Detail | |
| 0.013 | Malignant neoplasm of prostate | NA | BeFree,GAD | Detail | |
| <0.001 | endometrial carcinoma | NA | BeFree | Detail | |
| 0.080 | Necrotizing Enterocolitis | NA | RGD | Detail | |
| <0.001 | Recurrent cystitis | NA | BeFree | Detail | |
| <0.001 | Carcinogenesis | NA | BeFree | Detail | |
| 0.001 | prostate carcinoma | NA | BeFree | Detail | |
| <0.001 | Lesion of stomach | Toll-like receptor 1 and 10 polymorphisms, Helicobacter pylori susceptibility an... | BeFree | 25687912 | Detail |
| <0.001 | Carcinoma of lung | We mainly elucidate that miRNA-15a/16 can enhance radiation sensitivity by regul... | BeFree | 25442346 | Detail |
| <0.001 | Ewings sarcoma-primitive neuroectodermal tumor (PNET) | The present study aimed to investigate biomarkers of PNETs in the primary diseas... | BeFree | 25310565 | Detail |
| <0.001 | stomach carcinoma | NA | BeFree | Detail | |
| <0.001 | Malaria, antepartum | NA | BeFree | Detail | |
| 0.003 | Pancolitis | NA | BeFree,GAD | Detail | |
| <0.001 | Candidemia | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of ovary | NA | BeFree | Detail | |
| <0.001 | Hereditary Nonpolyposis Colorectal Cancer | NA | BeFree | Detail | |
| <0.001 | Marginal Zone B-Cell Lymphoma | NA | BeFree | Detail | |
| <0.001 | Chronic Q Fever | For TLR1, increased interleukin 10 responses to C. burnetii in individuals carry... | BeFree | 25722298 | Detail |
| <0.001 | Bacteroides fragilis infection in conditions classified elsewhere and of unspecified site | NA | BeFree | Detail | |
| <0.001 | colorectal cancer | NA | BeFree | Detail | |
| <0.001 | Severe Sepsis | NA | BeFree | Detail | |
| <0.001 | ALPHA-THALASSEMIA/MENTAL RETARDATION SYNDROME, NONDELETION TYPE, X-LINKED | The present study aimed to investigate biomarkers of PNETs in the primary diseas... | BeFree | 25310565 | Detail |
| 0.003 | coronary artery disease | NA | BeFree,LHGDN | Detail | |
| <0.001 | liver carcinoma | NA | BeFree | Detail | |
| <0.001 | Allergic rhinitis (disorder) | Three SNPs located in the TLR6-TLR1 locus had the lowest P-values and Q-values <... | BeFree | 25066275 | Detail |
| 0.002 | Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | NA | GAD | Detail | |
| 0.003 | Infection | NA | LHGDN | Detail | |
| <0.001 | adenocarcinoma | NA | BeFree | Detail | |
| <0.001 | alopecia areata | Association between TLR1 polymorphisms and alopecia areata. | BeFree | 24780078 | Detail |
| <0.001 | anemia | NA | BeFree | Detail | |
| <0.001 | arthritis | NA | BeFree | Detail | |
| 0.003 | rheumatoid arthritis | NA | BeFree,GAD | Detail | |
| 0.005 | aspergillosis | NA | GAD,LHGDN | Detail | |
| 0.130 | asthma | NA | BeFree,GAD,GWASCAT,LHGDN | Detail | |
| 0.002 | bacteriuria | NA | GAD | Detail | |
| <0.001 | Behcet Syndrome | A significant defect in the response to cognate agonists of TLR1/2 heterodimer a... | BeFree | 23940075 | Detail |
| <0.001 | bipolar disorder | These genes were used in co-expression analysesthat revealed the pairs CCR1/SERP... | BeFree | 25487697 | Detail |
| <0.001 | bronchiolitis | NA | BeFree | Detail | |
| 0.002 | bronchiolitis obliterans | NA | GAD | Detail | |
| 0.002 | Bronchiolitis, Viral | NA | GAD | Detail | |
| 0.002 | candidiasis | NA | GAD | Detail | |
| <0.001 | Non-small cell lung carcinoma | First, an inverse correlation between the expression of miR-15a/16 and TLR1 prot... | BeFree | 25442346 | Detail |
| 0.001 | renal cell carcinoma | NA | BeFree | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| At baseline, we found CD14, IL1R1 and TLR-1 were down-regulated significantly (≥2 fold change) and t... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Among the 178 SNPs, 24 were significantly associated with NSCLC prognosis in different genetic model... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Our study, for the first time, indicates that TLR1 and TLR6 gene might play important roles in the e... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Collectively, our results show that TIGIT and PD-1 regulate the expansion and function of TA-specifi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| A common TLR1 polymorphism is associated with an increased risk of laboratory-defined neurosyphilis,... | DisGeNET | Detail |
| The TLR1 variant genotype was associated with a lower risk of BCG osteitis (aOR 0.554, 95%CI 0.336-0... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Polymorphisms in the genes for TLR1 (a T→G mutation at position 1805), TLR2 (a G→A mutation at posit... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The present study aimed to investigate biomarkers of PNETs in the primary disease site to predict PH... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We mainly elucidate that miRNA-15a/16 can enhance radiation sensitivity by regulating the TLR1/NF-κB... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Moreover, the polymorphisms in the toll-like receptor 1 (TLR1) and TLR2 genes varied between the pig... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| A significant downregulation in the gene expression of TLRs 3, 4 and 5 and upregulation of TLR1 was ... | DisGeNET | Detail |
| The present study aimed to investigate biomarkers of PNETs in the primary disease site to predict PH... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Toll-like receptor 1 and 10 polymorphisms, Helicobacter pylori susceptibility and risk of gastric le... | DisGeNET | Detail |
| We mainly elucidate that miRNA-15a/16 can enhance radiation sensitivity by regulating the TLR1/NF-κB... | DisGeNET | Detail |
| The present study aimed to investigate biomarkers of PNETs in the primary disease site to predict PH... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| For TLR1, increased interleukin 10 responses to C. burnetii in individuals carrying the risk allele ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The present study aimed to investigate biomarkers of PNETs in the primary disease site to predict PH... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Three SNPs located in the TLR6-TLR1 locus had the lowest P-values and Q-values < 0.1 when using a we... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association between TLR1 polymorphisms and alopecia areata. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| A significant defect in the response to cognate agonists of TLR1/2 heterodimer and TLR4 was also obs... | DisGeNET | Detail |
| These genes were used in co-expression analysesthat revealed the pairs CCR1/SERPINA1, CCR5/HCST, C1Q... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| First, an inverse correlation between the expression of miR-15a/16 and TLR1 protein was revealed in ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- dbSNP
- rs386502799 dbSNP
- Genome
- hg19
- Position
- chr4:38,797,876-38,806,412
- Variant Type
- snv
Genome browser